Dequalinium Chloride_522-51-0_DataSheet_MedChemExpress

Product Name:

Dequalinium Chloride CAS No.:

522-51-0Cat. No.:

HY-B0567MWt:

527.57Formula:

C30H40Cl2N4Purity :>98%

Solubility:Mechanisms:

Biological Activity:

References:

Caution: Not fully tested. For research purposes only

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[1]. Kramer, W., [Treatment of tonsillitis with dequalinium chloride]. Fortschr Med, 1977. 95(16): p. 1108-10.[2]. Gamboa-Vujicic, G., et al., Toxicity of the mitochondrial poison dequalinium chloride in a murine model

system. J Pharm Sci, 1993. 82(3): p. 231-5.

Dequalinium Chloride is a selective blocker of apamin-sensitive K+ channels.

Target: Potassium Channel Dequalinium Chloride is a selective blocker of apamin-sensitive K+ channels. Treatment with Dequalinium chloride did not influence conditions caused by haemolytic streptococci -- verified by bacteriological

examinations of pharyngeal smears -- inspite of its efficiency in vitro [1]. Dequalinium chloride (DECA), a cationic, lipophilic mitochondrial poison, selectively targets the mitochondrial membrane of certain epithelial carcinoma cells, in which it inhibits cellular energy production. Higher DECA doses under either regimen

induced severe toxic effects and mortality [2]....

Pathways:Membrane Tranporter/Ion Channel; Target:Potassium Channel Product Data Sheet

DMSO

11 D e e r P a r k D r i v e , S u i t e 102D M o n m o u t h J u n c t i o n , N J 08852,U S A

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