Sectoral shocks and aggregate fluctuations

Sectoral shocks and aggregate fluctuations
Sectoral shocks and aggregate fluctuations

?

Financial support from the Sloan Foundation and National Science Foundation (SBR-9507978)is gratefully acknowledged.I thank Susanto Basu,Larry Christiano,Marty Eichenbaum,Jon Faust,John Fernald,Jonas Fisher,Anna Horvath,Nati Krivatsy,Chad Jones,Andrew Levin,Prakash Loungani,Kiminori Matsuyama,Joseph Mattey,Wolfgang Pesendorfer,John Shea,Mark Watson,and seminar participants at the Federal Reserve Board,International Division,Northwestern,Cornell,Carnegie Mellon,University of Chicago GSB,Stanford,UCSD,Boston University,Dar-tmouth,Yale,Wharton,Pompeu Fabra,and the NBER Summer 1995Economics Fluctuations Conference.Rishi Goyal provided sterling research assistance.I owe a special note of gratitude to Michele Boldrin for his encouragement and many critical comments.All errors are,of course,my own.

*Corresponding author.Tel.:650-723-4116.

E-mail address:mhorvath @https://www.360docs.net/doc/6517866456.html, (M.

Horvath)

Journal of Monetary Economics 45(2000)69}106

Sectoral shocks and aggregate #uctuations ?

Michael Horvath *

Department of Economics,Stanford Uni v ersity,Stanford,CA 94305,USA

Abstract

This paper presents a multisector dynamic general equilibrium model of business cycles with a distinctive feature:aggregate #uctuations are driven by independent sectoral shocks.The model hypothesizes that trade among sectors provides a strong synchroniza-tion mechanism for these shocks due to the limited,but locally intense,interaction that is characteristic of such input trade #ows.Limited interaction,characterized by a sparse intermediate input-use matrix,reduces substitution possibilities among intermediate inputs which strengthens comovement in sectoral value-added and leads to a postpone-ment of the law of large numbers in the variance of aggregate value-added.The chief virtue of this model is that reliance on implausible aggregate shocks is not necessary to capture the qualitative features of macroeconomic #uctuations.Building on Horvath,1998,Review of Economic Dynamics 1,781}808,which establishes the theoretical foundation for the relevance of limited interaction in the context of a stylized multisector model,this paper speci "es a more general multisector model calibrated to the US 2-digit Standard Industrial Code economy.Simulations prove the model is able to match

0304-3932/00/$-see front matter 2000Elsevier Science B.V.All rights reserved.

PII:S 0304-3932(99)00044-6

70M.Hor v ath/Journal of Monetary Economics45(2000)69}106

empirical reality as closely as standard one-sector business cycle models without relying on aggregate shocks. 2000Elsevier Science B.V.All rights reserved.

JEL classi x cation:E1;E32;C67

Keywords:Aggregate#uctuations;Sectoral interaction;Comovement;Input}output

1.Introduction

Explaining aggregate economic#uctuations has occupied theorists and em-piricists throughout this century.To an outside observer of the economic system,it would seem that forces are at play that cause otherwise heterogeneous consumers and producers to simultaneously vary demand and production intensity.Furthermore,once begun,the concerted behavior controls the econ-omy's direction for a signi"cant length of time.These two fundamental regulari-ties of business cycles,sectoral comovement and persistence,have motivated a plethora of models in which exogenous disturbances a!ect all sectors equally, are inherently highly persistent,and serve as the driving force for#uctuations in real aggregate variables.A central problem with this approach is the lack of good candidates for exogenous aggregate shocks that are large enough and persistent enough to account for the volatility in GDP.Consequently,such models seem implausible to many economists.(See Summers,1986;Lucas,1987; Mankiw,1989;McCallum,1989;Cochrane,1994.)

Without relying on aggregate shocks,the outside observer of the economy needs an alternative synchronization mechanism to explain what he or she sees. The organization of production in the economy presents itself as a natural candidate.Most commodities are inputs to the production processes of other commodities.Depending on substitution possibilities,higher production in one sector may necessitate higher production in the sectors supplying its intermedi-ate inputs.If each sector of the economy independently experiences variations in productivity,is it possible that the e!ects of such variations survive at an aggregate level?

This question was asked by Long and Plosser(1983)in one of the earliest Real Business Cycle(RBC)models.They speci"ed a six-sector model of the economy with intermediate input linkages and uncorrelated sector-speci"c shocks.While results at this high level of aggregation were generally encouraging,subsequent attempts to preserve aggregate volatility at lower levels of aggregation were not. Conventional wisdom(e.g.Lucas,1981)suggests an explanation for the limited success of the Long}Plosser model.The e!ect of uncorrelated sector-speci"c disturbances may tend to dissipate through aggregation since,by the law of large numbers,negative variations in some sectors o!set positive variations in other sectors.

M.Hor v ath/Journal of Monetary Economics45(2000)69}10671 The"eld of business cycle research is thus faced with a two-pronged dilemma. Extant theoretical models that account for certain salient features of business cycles are predicated on random disturbances that have little empirical support while the sector-speci"c disturbances that are more readily observable have not been successfully incorporated into theoretical models.The irony in this conun-drum is that most of the research e!ort has been focused on the former class of models and few attempts have been made to formulate arguments for why the law of large numbers may not apply in the latter class of models.This paper entertains the Long}Plosser sectoral shocks hypothesis again,with a di!erent model,in order to explore what forces may limit the law of large numbers. Recent literature has focused on several mechanisms that may contribute to the weakening of the law of large numbers.Examples include asymmetries or threshold e!ects,limited interaction,external economies,and monopolistic competition. The analysis presented here builds on results in Horvath(1998) which explores law of large numbers properties in a highly stylized multi-sector dynamic stochastic general equilibrium(DSGE)model similar to the one originally used by Long and Plosser(1983).

The main insight from Horvath(1998)is that sectoral comovement and aggregate volatility at a given level of disaggregation are increased,and the rate at which aggregate volatility declines upon disaggregation is decreased if the input-use matrix is characterized by limited interaction of a special form:few full rows and many sparse columns.Full rows in the input-use matrix indicate sectors that are important inputs in the production processes of many sectors.If there are few of these key input-sectors,the e!ects of their speci"c shocks are less likely to cancel upon aggregation.Sparse columns indicate that most sectors' production processes are highly speci"c with regard to intermediate inputs.This lack of substitutability among intermediate inputs forces sectors to react to shocks to the key-input sectors in like fashion.It is shown analytically in Horvath(1998)that the rate at which the law of large numbers applies in that highly stylized multi-sector model is proportional to the rate of increase in the number of predominantly full rows in the input-use matrix,rather than being proportional to the rate of increase of the number sectors.Examination of the US input-use matrices at di!erent levels of disaggregation reveals that the rate of increase in the number of predominantly full rows is signi"cantly slower than the rate of disaggregation.Roughly,out of M sectors,only(M are broadly used as inputs.

See Bak et al.(1993),Boldrin and Woodford(1990),Scheinkman(1990),Scheinkman and Woodford(1994),Jovanovic(1984),Shea(1994),Murphy et al.(1989),Basu and Fernald(1997),Basu et al.(1999),and Verbrugge(1996).

Dupor(1996)presents conditions for the same model under which the nature of linkages between sectors is irrelevant for the volatility of aggregate variables.Horvath(1998)directly compares and discusses the two sets of results.

72M.Hor v ath/Journal of Monetary Economics45(2000)69}106

In Horvath(1998),preferences and technologies are speci"ed to yield an analytical solution to the social planning problem of allocating resources across the sectors in response to idiosyncratic technology shocks. The advantage of having an analytical solution to the model's equilibrium is that it directly reveals the channel by which sectoral interaction a!ects the stochastic properties of the model's aggregates.The disadvantage is that the restrictions placed on the model separate it from the economy we actually observe.In particular,labor market#uctuations are absent from the model since preferences over consump-tion and leisure are assumed to be logarithmic.In this paper restrictions on preferences and technologies in the model are https://www.360docs.net/doc/6517866456.html,ing numerical ap-proximation techniques,the more general model is shown to exhibit the same features as the model in Horvath(1998).

A complete calibration exercise in the spirit of Kydland and Prescott(1982) and King et al.(1987)is also undertaken here.The model is parameterized to the US economy at roughly the two-digit Standard Industrial Code(SIC)level of disaggregation.Simulation reveals the time-series properties of the multisector model's aggregates are qualitatively similar to that of the data and to one-sector business cycle models without relying on aggregate shocks.Interestingly,the aggregate Solow residual series estimated from the simulated data is quite variable,with a standard deviation of roughly one-half that of aggregate value-added,as it is in US data.The interpretation of this"nding is that empirically observed shocks to aggregate multifactor productivity may simply be an artifact of aggregation and need not be interpreted as evidence of aggregate shocks.

The chief virtue of a model that can generate aggregate#uctuations from sector-speci"c shocks is that such shocks are constantly being observed and noted in the academic and trade press.Some recent examples of signi"cant, identi"able,sector-speci"c shocks include the introduction of automated teller machines in the banking sector,the severe1993southern drought and Midwes-tern#ood in the agricultural sector,the1996strike at a General Motors brake plant in Ohio,digital compression in cable television transmission,and the development of enhanced oil recovery methods in oil drilling.

Two caveats should be mentioned before proceeding;the goal of this research is not to prove that aggregate shocks are irrelevant to the study of macroeco-nomic#uctuations.It is simply to reduce economists'reliance on them by identifying a role for smaller shocks in generating aggregate movements.At the same time,the goal of this research is not to drive the location of stochastic shocks to the individual"rm level and still generate aggregate#uctuations.The results contained herein and in Horvath(1998)do not obviate the Law of Large Log preferences and full depreciation of capital stocks within one period are assumed to achieve analytical solutions.

M.Hor v ath/Journal of Monetary Economics45(2000)69}10673 Numbers,they just postpone it,making it possible for a multi-sector model parameterized to the2-digit SIC level of disaggregation to preserve su$cient aggregate volatility to match business cycle facts.

The rest of the paper is organized as follows.Section2describes the model. Section3calibrates parameters to match the US economy.Section4presents simulation results from the model that replicate the law of large numbers postponement present in the stylized model of Horvath(1998).Section5reports the performance of the model via moment comparisons with the US data and a popular one-sector DSGE model.Section6summarizes the main"ndings and brie#y comments on future research in the same vein.

2.The model

The model presented is the decentralized competitive equilibrium problem and solution.While the social planning problem is equivalent,aggregation of the multisector model is most naturally carried out using Divisia indices con-structed from both price and quantity data.Since the decentralized model carries prices explicitly,it is the more natural speci"cation to use.

2.1.En v ironment

The economic system consists of M distinct sectors,indexed by h"1,2,M, each producing a di!erent good.The production of each sector is controlled by "rms that operate so as to maximize their expected present discounted value to shareholders.Firms operate constant returns-to-scale production technologies that use capital,labor,and intermediate goods purchased from other sectors as inputs.The technologies are distinct across the sectors.There is one form of uncertainty in the economy.Multi-factor productivity in each sector is subject to stochastic innovations that are not perfectly correlated(and may be mutually independent)across sectors.

The output of each sector goes to potentially di!erent three uses.Some goods are used as intermediate inputs in the production of other goods;sectors do not necessarily use the same intermediate inputs.Some goods are built into the capital stocks of the sectors in the economy;each sector has a distinct capital stock.Finally,a portion of output in each sector is supplied to a"nal consump-tion market.The consumer-shareholders allocate labor resources to the various productive activities and make savings decisions that return investment funds to the"rms.

A note on timing is appropriate here.In the model it is assumed that intermediate inputs are delivered and either used within one period or built into the capital stock of the purchasing sector.While the real world may not conform exactly to this speci"cation,it seems like a reasonable place to start for several

reasons.First,the period length is parameterized to one quarter-year.Any delivery lags in the data less than three months long will not show up with this de"nition of the period length.Second,the labeling of intermediate inputs as durable and non-durable in the model is not arbitrary,but is guided by the intermediate input-use and capital input-use tables for the US economy.How-ever,other timing assumptions have been employed in previous research.For example,Long and Plosser(1983)assume that intermediate inputs arrive with a one period lag and then depreciate fully if not used.Kydland and Prescott (1982)specify a one-sector model with capital adjustment costs that generate lagged responses of investment to exogenous shocks.Clearly it would be interesting to explore the e!ects that holding inventories of non-durable inter-mediate goods and allowing for delivery lags in intermediate good orders have on the behavior of the system.Unfortunately space limitations do not permit these modi"cations.

2.2.Agents and preferences

Preferences of agents in the economy closely resemble those used in Spence (1976),Dixit and Stiglitz(1977),Kiyotaki(1987),Blanchard and Kiyotaki(1987), and Gali(1996).There are N identical consumers in the economy who own all shares of all"rms.Each sector has N identical"rms.Without loss of generality,

N and N are normalized to unity and the remainder of the exposition only considers the representative consumer's and representative"rm's maximization problems.

The representative consumer seeks to maximize his discounted,time separ-able utility stream given in(1).His income is composed of wages earned in each of the M production processes and the net change in the value of his stock portfolio.

max E

R

R[C R?Q R] \R!1

1!

50, (1,

s.t.

+

Q

p Q R c Q R4

+

Q

p L Q R n Q R#

+

Q

(d Q R#q Q R)s Q R!

+

Q

q Q R s Q R> ,a R.

(1)

In(1), is a discount factor,C R is an aggregate consumption index,and?R is an aggregate leisure index at time t.The parameter controls the degree of risk aversion and is inversely proportional to the elasticity of intertemporal substitu-tion.The parameter controls intratemporal substitution between consumption and leisure.The consumption aggregate is a function C(c R)where c R is a vector of consumption quantities.The leisure aggregate is a function?(n R)where n R is a vector of hours worked in each sector at time t.

The consumer's budget constraint is represented by the sum of goods pur-chased,c Q R,valued at their respective prices,p Q R,equaling total income in period t. 74M.Hor v ath/Journal of Monetary Economics45(2000)69}106

M.Hor v ath/Journal of Monetary Economics45(2000)69}10675 The maximization problem is also constrained by an initial share condition s Q given for s"1,2,M,and a condition that states that the price of all shares must stay bounded away from zero.Other variables subscripted by t denote time t values:p L Q R denotes hourly wage in sector s;d Q R denotes the dividend paid on one share held in sector s;q Q R denotes the share price of one share in sector s; s Q R denotes share holdings in sector s;and a R denotes the income#ow after establishing share holding positions,s Q R> ,for period t#1at current share prices.

The consumer's aggregate consumption index C(c R)has the constant elasticity of substitution(CES)form

C(c R)" + Q Q(c Q R) N\ N N N\ ,

for an elasticity of substitution '1and aggregation weights Q.This form implies that the worker will choose c F R to satisfy(2).

c F R" p F R P R \N a R P R( F)N,h"1,2,M.(2) The aggregate price index P R is given by

P R" + Q ( Q)N(p Q R) \N \N .

Substitution and algebraic manipulation yield the result:C(c R)"a R/P R:The aggregate consumption index is equal to nominal consumption expenditure divided by the price level.

The representative consumer is endowed with one unit of time in each period. The aggregate leisure index is assumed to take the form

?(n

R)" 1! + Q (n Q R) O> O O O> , '0.(3) At "R,labor hours are perfect substitutes as far as the worker is concerned. This would imply that the worker would devote all time to the sector paying the highest wage.Hence,at the margin,all sectors pay the same hourly wage.For (R,hours worked are not perfect substitutes for the worker.An interpreta-tion of this is that the worker has a preference for diversity of labor and hence would prefer working closer to an equal number of hours in each sector even in the presence of wage di!erences across sectors.Under standard Walrasian labor market clearing,the consumer takes p L F R,the hourly wage in sector h,as given

See Appendix A for derivation of"rst-order conditions and solution proceedures.

and chooses n F R to equate the marginal rate of substitution between consumption and leisure to this wage.This implies the condition for labor supply in Eq.(4)

n F R"(p L F R)O ?O

R(1!?R)

( a R)

.(4)

A further discussion on leisure preferences in(3)is warranted.The motivation for this speci"cation is the desire to capture some degree of sector speci"city to labor while not deviating from the representative consumer/worker assumption. Considering(4),sectors in which nominal wages are high,in steady state or in a#uctuating economy,draw more of the representative consumer's time endow-ment due to the ordinary substitution e!ect.Wage di!erences across sectors,in steady state or in a#uctuating economy,arise from parametrically imposed di!erences in labor productivity across sectors,made explicit in Section2.3. Optimal share holdings are achieved by satisfying the intertemporal condi-tion in Eq.(5)

q F R

P R a R P R \R?Q \R R

" E

R (d F R> #q F R> )

P R> a R> P R> \R?Q \R R> ,h"1,2,M.(5)

2.3.Firms and production

A quantity,y F R,of good h is produced by combining capital in the sector,k F R, labor devoted to the sector,n F R,and an index of intermediate inputs M F R in a production process described by

y F R"A F R(k F R)?F(n F R)@F(M F R)A F.(6) The index of intermediate inputs for sector h is given by a CES index of intermediate input quantities,in(7),with elasticity of substitution K.The associated price index for intermediate input index M F R is given in(8).The notation B+F denotes the set of sector indices that are inputs to the production of good h,the intermediate`buy-from a set for sector h.

M F R, Q Z+F x QF(m F R Q) N K\ N K N K N K\ ,(7) P+F R, Q Z+F(x QF)N K(p Q R) \N K \N K .(8) 76M.Hor v ath/Journal of Monetary Economics45(2000)69}106

Therefore,the model does not impose equal steady state hours and wages in each sector.Of course,for su$ciently close to R this result obtains.

The matrix K is time-invariant only under the Cobb }Douglas assumption ( K "1)used in the baseline simulations.For values of K di !erent from unity, K denotes the steady-state cost shares for non-durable intermediate goods.In what follows,the time-invariant intermediate input-use matrix is K . Let GH be the ij th element of K ,denoting the cost share of total expenditure on intermediate goods in sector j due to purchases of intermediate goods from sector i .Let H denote the sum of the j th column of K .The weights in (7)are normalized to satisfy the following conditions: Q Z +F x QF "1and x QF " QF / F .When K

"1,(7)corresponds to the Cobb }Douglas speci "cation:M F R , Q Z +F (m F R Q )V QF with price index P +F R , F Q Z +

F p Q R QF

V QF .In (6)A F R represents the state of technology in sector h .It is assumed that A F R

follows a stochastic process described by ln(A F R )" F

ln(A F R \ )# F R .(9)In (9) F R is a normally distributed mean zero random variable with E [ R R ]" .Section 3provides a fuller description of the distributional assumptions on R .Several comments are appropriate here.First,the stochastic process for technology does not incorporate a deterministic trend.The model is interpreta-ble as the detrended version of another model that does allow for trending multifactor productivity.Second,the assumption of constant returns to scale implies that F # F # F "1.Third,note that when x GH "0(equivalently GH "0),good i is not used as an intermediate input in the production process for good j ,hence m H R G "0and i ,B +H .Finally,factor share vectors , ,and ,and the input-use matrix K are assumed to be time invariant.As in Kiyotaki (1987)and Gali (1996)capital accumulation is accomplished through an investment process described by k F R> !(1! F )k F R

" (i F R ),(10)where F is a sector speci "c depreciation rate inside the unit interval and the composite investment good is created by combining inputs according to

(i F R )" Q Z 'F

x QF (i F R Q ) E \ E

E E \ .(11)The notation i

F R Q denotes the quantity of good s purchased by sector h for investment purposes and Q Z 'F denotes the sum over all s in the investment `buy-from a set of sector h ,the set of sectors from whom sector h purchases durable intermediate goods.x QF

is the weight that good s receives in the M.Hor v ath /Journal of Monetary Economics 45(2000)69}10677

As with K , 'is time invariant only under the Cobb }Douglas assumption ( "1)used in the baseline simulations.For values of di !erent from unity, 'denotes the capital goods cost shares in steady state.

production of capital in sector h .With this speci "cation and that in (7),"rms buy goods from a subset of sectors for capital accumulation purposes and buy goods from a subset of sectors for intermediate good purposes.Let the time-invariant capital input-use matrix be 'with typical element GH denoting the cost share out of total expenditure on capital goods in sector j due to purchases of capital goods from sector i . Note that

Q Z '

F QF "1.The weights x QF are related to QF by x QF " E QF .Firms in sector h will maximize e !ective investment (i F R )for a given level of investment expenditure,

z F R , Q Z '

F p Q R i F R Q .This gives rise to investment-related demands of the form

i F R Q "x E QF p Q R F R \E (i F R ),s 3B 'F ,h "1,2,M (12)

and an e !ective investment level of (i F R )"z F R / F R where the investment price index for sector h is given by

F R " Q Z 'F x E QF (p Q R ) \E \E .

The notation has a simple interpretation if one considers (i F R )as the investment good for sector h and F R as its price.The total expenditure on investment,z F R ,is equal to (i F R ) F R ,a result that can be obtained by manipulating (12).Firms in sector h are instructed by the shareholders to maximize the present discounted value of real dividends as in Eq.(13).Note that dividends are discounted by the representative shareholder 's marginal utility of consumption.Absent complete contingent claims markets,this asset pricing kernel is required to equate the competitive equilibrium solution proposed here with the optimal control solution.

max E R R d F R P R a R P R \R ?Q \R R .(13)

78M.Hor v ath /Journal of Monetary Economics 45(2000)69}106

The maximization problem is constrained by a given initial condition for k F and by Eqs.(6)and(14).The latter describes dividends in sector h at time t.

d F R"p F R y F R!p L F R n F R!(k F R> !(1! F)k F R) F R!P+F R M F R.(14) Total demand for good h is given by Eq.(15).Th

e notation S'F and S+F on the summation operators denote the`sell-to a sets for investment and intermediate input use,respectively,the set o

f sectoral indices to which sector h sells a portion of its output for these uses.

y F B R,c F R#

Q Z1'F i Q R F#

Q Z1+F

m Q R F.(15)

2.4.Perfectly competiti v e equilibrium

Here I assume that sectors behave in a competitive fashion and charge prices equal to marginal cost.It should be noted that demand in sector h is a decreas-ing function of the price in sector h.This has led Kiyotaki(1987),Blanchard and Kiyotaki(1987),and Gali(1996)to consider the e!ects of monopolistic competi-tion among"rms in di!erent sectors.Basu et al.(1999)discuss the e!ect of monopolistic competition and non-constant returns to scale on aggregation in an otherwise identical model setting to the one presented here.

Price is equal to the marginal cost of production in each sector.The marginal cost function,taking prices as given,is given by

(x F R;p R,2,p+R,p L F R,A F R)

"g

S F(A F R) \ \? F(p L F

R)

@ \? F y F R k F R ? \? F(P+F R) A \? F.(16)

The notation( /(1! ))F,for example,denotes( F/(1! F))and g S

F is a constant

function of the technological coe$cients.Note that the price in sector h is an increasing function of the prices in the sectors from which it purchases inter-mediate products and a decreasing function of the state of technology in sector h,ceteris paribus.

Labor demand is determined by Walrasian market mechanisms.Firms take the wage rate as given and equate labor's marginal product to the wage to determine demand.Consumers,also taking the wage as given,balance the disutility from reduced leisure with the bene"t of increased labor income to determine supply.The equilibrium condition is summarized by

n F R" F p F R y F R a R?R(1!?R) O O >O .(17)

Sector h demands intermediate goods from potentially all sectors,even its own.The optimal level of the intermediate good index in sector h equates its per M.Hor v ath/Journal of Monetary Economics45(2000)69}10679

unit cost,P+F R,with its marginal product resulting in Eq.(18).The optimal amount of each input purchased to achieve M F R is given by(19).Again, B+F denotes the set of sectors from which sector h purchases intermediate goods (corresponding to the row indices of the non-zero cells in column h of K).

P+F R" F p F R y F R

M F R

,(18)

m F R Q" QF p F R y F R p R N K(M F R) \N K,s3B+F.(19)

The"rms'intertemporal decision at time t concerns the level of capital stock that is desired at time t#1.Di!erentiating(13)combined with(14)with respect to k F R> results in the"rst-order condition for optimal capital stock in sector h:

F R

P R a R P R \R?Q \R R

" E

R 1P R> a R> P R> \R?Q \R R> p F R> y F R> k F R> F#(1! F) F R> .(20) Finally,the model is closed by specifying market clearing for good h y F R"y F B R.(21) Simple manipulation of"rst-order conditions reveals that consumers'total income is independent of share holdings and is given by

a R"+

Q

p Q R y Q R( Q# Q)!(k Q R> !(1! Q)k Q R) Q R.(22)

De x nition:A perfectly competiti v e equilibrium consists of shocks vectors+ R, R , price vectors+p R, R,p L R, R ,and quantity vectors+k R,n R,M R,c R,i R,y R, R such that 1.productivity levels+A R, R follow their log-autoregressive laws of motion subject to shocks+ R, R ,

2."rms maximize present discounted value of dividends to shareholders,

3.consumers maximize lifetime utility,

4.prices clear labor markets and goods markets.

The dynamic program as speci"ed is non-linear in its state and co-state variables.Except for a special case of the parameter set,described in Horvath (1998),analytical solutions are not possible.Therefore,a suitable approximate solution technique is required.Because the sta te space is very large,I elect to use the solution method of log-linearizing the system of equations around their 80M.Hor v ath/Journal of Monetary Economics45(2000)69}106

Note,the price in sector M can,without loss of generality,be normalized to unity every period.The dimension of the state space is reduced to 3M !1when the coe $cient controlling the consumer 's risk aversion equals zero since then a R does not appear in the "rm 's intertemporal "rst-order condition for optimal choice of k R> . See Sato (1975)for the relative merits of the Divisia method.

steady state values with "rst-order Taylor Series expansions.A formal justi "ca-tion for this solution method is presented in Woodford (1986),Theorem 1.A derivation of the linearized solution appears in Appendix A.

The solution to the linear expectational di !erence equations is determined by state space methods in X R and X R> ,where denotes a variable 's percent deviation from its steady-state value and X R ,+a R ,p G R ,A H R ,k H R ,+\ +G H .This implies 3M state variables. The model then has a state space representation given by X R " X R \ where is a 3M ;3M matrix that depends on the parameters of the model,including the input-use matrix K

.2.5.Aggregation

Since this exercise intends to say something about aggregate quantities it is necessary to de "ne the method of aggregation from nominal sectoral output to real aggregate value added.In doing so I am drawing heavily on the accounting methods advocated by Basu and Fernald (1997).Time subscripts are dropped for the remainder of this section to reduce notational clutter.

In nominal terms,the de "nition of sectoral and aggregate value added is quite straightforward.Nominal value added in sector h is de "ned as the di !erence between the value of gross output in that sector and the cost of the intermediate inputs used to produce it as in

p T F v F "p F y F !P +F M F .(23)Aggregate nominal value added is simply the sum over all sectoral nominal value added amounts:p T v , +G p T G v G .Straightforward manipulation reveals that p T v "a from (22).From the perspective of the representative consumer who owns shares in sector h ,nominal value added represents the income generated in sector h ,above the cost of the intermediate inputs,that can be used to increase this consumer 's expenditure on "nal goods.

To arrive at real value added,it is necessary to pick an accounting method that is internally consistent so that the national accounting identity that holds in nominal prices also holds in constant prices.I de "ne value added growth rates with Divisia indices which are de "ned in terms of growth rates.The appendix contains a detailed description of the construction of Divisia indices for this model economy.

M.Hor v ath /Journal of Monetary Economics 45(2000)69}10681

82M.Hor v ath/Journal of Monetary Economics45(2000)69}106

3.Parameterization

The parameters that must be speci"ed to complete the model are summarized below:

E Preferences: , , , , ,+ F,+F

E Production:M,+ F, F, F, F,+

F , K, ', , K,

E Shocks:+ F,+

F , .

3.1.Preference and production parameters

Most of these parameters are set to empirical estimates from the US economy. For simulations in Section5,the level of disaggregation is set to M"36.This conforms closely to the2-digit SIC level,the sectoral de"nitions used by Jorgenson and Fraumeni(1987).The production parameters, F, F,and are derived from cost share data on the US economy presented in the latter work in the following manner.Time-average cost shares for capital,labor,and inter-mediate inputs are calculated for36sectors of the private US economy using annual data from1948to1985by dividing the cost of inputs at producer prices by the value of output at producer prices(hence,this assumes perfect competi-tion and constant returns to scale).The Cobb}Douglas coe$cients , ,and used in the simulations are the time-series averages from these calculations. The share F is divided across all interacting sectors using the fraction that the purchases from these sectors represent out of total intermediate purchases by sector h.The mean value of F across sectors in the simulations is0.16,the mean value of F is0.32,and the mean value of F is0.52.Table1lists these parameter values along with the sectoral de"nitions.

The1977detailed intermediate input-use matrix is used to parameterize K. This matrix can be aggregated up to various useful levels.In particular,law of large numbers properties of the model are explored in Section4using the matrices K , K , K ,and K containing77,36,21,and6sectors, respectively.Simulations in Section5use K .

Data for the investment-use matrix 'come from the capital#ow table from 1977,presented and described in Silverstein(1985).The capital#ow table was converted to 'for77,36,21,and6sectors by aggregating as with K and dividing columns by their sums at each level of aggregation.

The time period considered here is the quarter year.Consistent with previous business cycle models,the discount factor, ,is chosen to be(1.03)\ implying an annual discount rate of3%;the sectoral depreciation rates, F,are those used in Jorgenson and Fraumeni(1987),and are given in Table1.

I thank John Fernald for kindly providing the 's.

Constant and trend terms were included in the regression,but results are largely the same if they are not included.

See Ashenfelter and Altonji (1980)and Altonji (1982)for an extended discussion and further references.

The parameters and control the volatility of hours and the fraction of time spent working in steady state,respectively.The parameter is estimated from the Jorgenson data on annual sectoral outputs,labor inputs,and labor share coe $cients as follows.Manipulating (17)and (3)yields

n F R

"(b F R )O O > (1!?R )(24)where b F R is the fraction of labor 's share of aggregate output accumulating to labor in sector h :

b F R , F p F R y F R +Q Q p Q R y Q R

.(25)Expressing (24)in percentage changes (denoted by above variables)and adding an estimation error term results in the M estimation equations

(n F R ! b Q R \ n Q R )" #1b F R #error F R h "1,2,M .(26)

The interpretation of (26)is that relative labor hour percentage changes in sector h (the left-hand side)are related to relative labor 's share percentage changes in sector h by the elasticity /( #1).

Estimating (26)by SUR with restricted to be identical across sectors results in a point estimate of 0.9996with a standard error of 0.0027. Hence a value of "1.00is used the baseline simulations reported below.This value compares favorably with micro-level studies on the wage elasticity of labor supply.The typical "nding in these studies is that labor supply elasticity is low. The uncompensated labor supply elasticity implied by "1is 0.5.It should be noted that,since (R ,wage di !erences across sectors persist in equilibrium.For comparison purposes,simulations are also presented below for the case "100and "2.The parameter is set so that total hours spent working in steady state represent one-third of the worker 's total time endowment.Contingent on "1,2and 100,this requires "13.4,7.1and 1.93,respectively.The elasticity parameters K , , ,and are worth considering in terms of their respective e !ects on output,consumption,investment and labor volatility.The value of K determines the elasticity of substitution among intermediate inputs for all sectors.It is hypothesized that lower values of K engender greater sectoral comovement and hence greater aggregate output volatility by reducing the ability of sectors to &avoid 'the shocks of their input supplying sectors.The M.Hor v ath /Journal of Monetary Economics 45(2000)69}10683

Using consumption shares in this manner actually hinders the model 's ability to generate aggregate volatility from independent sectoral shocks relative to a parameterization that assumes all sectors have equal weights in the consumer 's utility function.This is due to the fact that several of the least volatile sectors (e.g.food,wholesale and retail trade,and apparel)account for a disproportion-ate share of consumption expenditure in the data.

parameter controls the degree of substitutability between di !erent consump-tion goods.A larger value of implies goods are more substitutable and therefore consumption of a given good is more responsive to variations in its relative price.The parameter a !ects sectoral investment demand for a given investment good in an analogous fashion.The parameter controls both the degree of risk aversion and the degree of intertemporal substitution.As in-creases,workers become less willing to substitute utility intertemporally.This tends to decrease output,investment,and consumption volatility.Workers also become more risk averse and hence less willing to substitute consumption across productivity states.Again this reduces consumption volatility.At "1prefer-ences are logarithmic in the consumption and leisure aggregates.

While it would be desirable to calibrate K , , ,and to some empirical regularities of the US economy,there is little to guide such an exercise.Intuition and precedence suggest K 41and 51while even less information guides selection of reasonable ranges for and .Accordingly,the following baseline set of parameter values are used: K "1.00, "1.00, "1.00, "1.00.All elasticities of substitution are set to unity and the consumer has logarithmic preferences in the consumption and leisure aggregates.Variations from this baseline are then considered in the next section to explore the e !ects these parameters have on the simulation results.

Preference weights are related to empirically observed relative sectoral de-mand intensities as follows.At "1,the nominal consumption expenditure share of sector h in total consumption is constant and is given by "p F c F / p Q c Q .Consumption expenditure shares are calculated for the 36sectors using con-sumption data from the National Income and Product Accounts.Shares are averaged over the period 1959}1995.Values for calibrated in this manner are reported in Table 1.

3.2.The stochastic process for shocks

Completing the parameter set requires values for + F ,+F and .Employing the Jorgenson dataset used to construct F , F ,and F a sectoral productivity series could be constructed for each sector as the residual of outputs minus weighted factors inputs according to (6)(in logs).

ln(A F R ),ln(y F R )! F ln(k F R )! F ln(n F R )! F ln(m F R ).(27)84M.Hor v ath /Journal of Monetary Economics 45(2000)69}106

M.Hor v ath/Journal of Monetary Economics45(2000)69}10685 Values for ln(A F R)could be"t to(9)yielding regression estimates for+ F,+F and residuals,+ F R,+F ,that could be used to calculate .

Several authors including Burnside et al.(1996)(hereafter BER),Basu(1996), and Basu and Kimball(1994),have noted that variations in capital utilization will a!ect the measurement of total factor productivity under(27). In particu-lar,the variance of productivity shocks is likely to be reduced once they have been`corrected a for variations in capital utilization.These authors recommend several methods for accounting for variable capital utilization.The method of BER is particularly easy to implement with the Jorgenson dataset.BER assume that it is the#ow of services from capital stock k G that enters into the production function given in(6)and that this#ow is linearly proportional to energy usage. They recommend correcting ln(A F R)with data on sectoral energy usage as follows:

ln(A F R),ln(y F R)! F ln(e F R)! F ln(n F R)! F ln(m F R),(28) where e F R denotes the time t level of energy usage in sector h.

In the present analysis,correcting for capital utilization is important because it is likely that the sectoral covariance properties of R di!er with the correction in a systematic manner.By their nature,aggregate shocks should a!ect capital utilization in the same direction for a majority of sectors while the "rst-order e!ect of uncorrelated sectoral shocks should be uncorrelated move-ments in capital utilization across sectors.Therefore,failing to correct for varying capital utilization would overstate the cross-sector correlation in sec-toral total factor productivity growth.This indeed turns out to be the case.The average pairwise correlation(excluding the diagonal)among the from(27)is 0.14while from(28)it is0.09suggesting that sectoral shocks would appear to be more important relative to aggregate shocks after correcting for variations in capital utilization.

In the simulations reported below it is important to distinguish between model volatility generated by uncorrelated sectoral shocks versus aggregate shocks,something which depends on the exact structure of .To pin down the structure of ,further assumptions on are needed.Suppose that shocks to sector h were the sum of idiosyncratic shocks, F R,and aggregate shocks, R as in

F R, F R#b F R,h"1,2,M,(29) where b F controls the response of sector h to aggregate shocks,E( R R)"A for a diagonal matrix A,and E( R)" J.It will not be possible to decompose R as in(29)without additional restrictions on the model.For example,

Variable utilization may a!ect other input factors,as these and other authors have noted. However,in the present analysis only variable capital utilization is considered.

Developing an identi "cation scheme for (29)is beyond the scope of this paper but is the subject of Horvath and Verbrugge (1999).

King et al.(1987)report and use this standard deviation for aggregate technology shocks.

normalization of (29)for each h will not help much since there are a total of 2M #1unknowns.

Even without exact identi "cation of aggregate and sectoral shocks,it is possible to investigate the importance of uncorrelated sectoral shocks using the present setup.Loosely,the size of the diagonal elements of relative to the o !-diagonal elements indicate the size of uncorrelated sectoral shocks relative to aggregate shocks.Let denote the diagonal matrix of ,setting o !-diagonal elements to zero.Results will be reported for simulations based on both and .The "rst set of results provides a gauge on how well the model works in replicating the empirical moments of the US economy without relying on aggreg-ate shocks .The second set of results indicates how close the model lies relative to the data when both aggregate and uncorrelated sectoral shocks are present.This comparison is an upper bound on the likely importance of sectoral shocks since the typical diagonal element of is given by GG "A GG #b G J ,which contains a weighted aggregate shock variance.Therefore,this analysis would show conclusively that sector-speci "c shocks are unimportant if the model did a poor job of matching the data when parameterized the productivity shock distri-bution,while it would suggest that sector-speci "c shocks may be an important source of aggregate volatility if the model performs about as well under as under .

The values for F and the square roots of the diagonal elements of are reported in Table 1.The mean value for F is 0.93and that of ( is 0.022;however,there is considerable sectoral variation.It should be noted that F are shocks to gross output in sector h .They must be scaled up by 1/(1! )to gauge their size relative to sectoral value added.One statistic that can be used to assess the plausibility of these parameter values is the volatility of measured total factor productivity in the model simulations.The shocks should generate su $cient variation in aggregate total factor productivity residuals to match the empirically observed estimate of 0.0078. Statistics on aggregate total factor productivity are reported in the discussion of the simulation results.

Table 1tabulates all the parameters of the model discussed above.

4.Limited substitution ,limited interaction and the law of large numbers

At what rate does the volatility of aggregate value added decline in the model as the level of disaggregation increases?The purpose of this section is to 86M.Hor v ath /Journal of Monetary Economics 45(2000)69}106

M.Hor v ath/Journal of Monetary Economics45(2000)69}10687 Table1

Baseline parameter values for the2-digit SIC(M"36)model economy

Aggregate "0.993, "1.0, "1.0, "13.4

"1.0, "1.0, K"1.0

Sector 100;

( Agricultural Products0.570.310.130.010.91 3.600.01 Agricultural Services0.440.450.120.010.91 3.600.01 Metal Mining0.590.260.150.020.95 5.260.01 Coal Mining0.430.410.160.020.99 3.940.01 Petroleum and Natural Gas0.520.130.350.020.97 6.180.01 Nonmetallic Mining0.390.330.270.020.95 3.260.01 Construction0.570.370.060.040.980.800.01 Food and Kindred Products0.770.160.060.020.64 1.390.12 Tobacco Products0.510.200.290.020.96 2.340.01 Textile Mill Products0.640.280.080.020.88 1.810.01 Apparel0.640.320.040.020.990.630.04 Paper0.510.350.140.020.93 2.490.02 Printing and Publishing0.570.360.070.020.88 1.380.01 Chemicals0.610.250.140.020.94 1.450.03 Petroleum and Coal Products0.500.390.110.020.980.800.03 Rubber and Misc.Plastics0.600.220.180.020.96 2.370.01 Leather0.780.110.110.010.96 6.350.01 Lumber and Wood0.550.360.100.020.95 1.670.01 Furniture and Fixtures0.610.340.050.020.89 2.990.02 Stone,Clay,Glass0.510.350.140.020.960.930.01 Primary Metal0.660.230.110.020.92 1.660.01 Fabricated Metal0.520.380.090.020.90 1.020.01 Non-elec.Machinery0.490.390.130.020.91 1.320.01 Elec.Machinery0.530.370.100.020.960.970.02 Motor Vehicles0.610.340.050.020.93 2.320.04 Transportation Equipment0.670.200.130.020.90 1.910.01 Instruments0.360.500.140.020.84 1.590.01 Misc.Manufacturing0.550.360.090.020.90 2.340.01 Transportation Services0.590.270.140.010.97 1.550.03 Communication Services0.210.430.360.020.98 2.170.02 Electric Utilities0.240.520.250.020.98 1.540.02 Gas Utilities0.410.210.380.010.98 2.740.01 Wholesale and Retail Trade0.300.540.160.020.93 1.260.25 Finance,Insurance,and Real Estate0.560.210.230.010.97 1.420.01 Water and Sanitary Services0.610.250.140.030.95 1.190.13 Other Services0.240.420.340.030.97 2.370.01 Note:See text for calibration of these parameters and for descriptions of K and '.

establish that the results found in Horvath(1998)still hold in the more general model presented above.Speci"cally,Horvath(1998)presents a special case of the above model without preferences over leisure and with parameters set to "1, "0, "1, '"I K,and K"1.This permits analytical results

Having no full rows (no intermediate links at all)would not promote the maximum degree of aggregate volatility.In this case the law of large numbers applies exactly:sectors are distinct production economies so aggregate output moves with the average of all the independent shocks. In principle,these two measures of substitutability can both be involved in postponing the law of large numbers.However,it should be obvious that when connectivity is extremely low (for example,if most sectors use only one intermediate input with substantial intensity)the elasticity of substitution between intermediate inputs is irrelevant.Similarly,when the elasticity of substitution is very high,the degree of connectivity may matter less.

showing that the sparseness of K of a particular form results in greater volatility of aggregates for a given level of disaggregation and a slower decline in aggregate volatility for increasing levels of disaggregation.This postponement of the law of large numbers relies on K being characterized by few full rows and mostly sparse columns.The full rows represent &key input 'sectors,sectors that sell inputs broadly to many other sectors. The sparseness of the columns indicates the lack of substitution possibilities.The end result:the rate of decline of aggregate volatility depends on the rate of increase of the number of predomi-nantly full rows in K rather than on the rate of increase in the total number of rows (sectors).Examination of the US input-use matrices at di !erent levels of disaggregation reveals that the rate of increase in the number of predominantly full rows is signi "cantly slower than the rate of disaggregation.Roughly,out of M sectors,only (M are broadly used as inputs.Horvath (1998)also presents a comparison of these results with the results in Dupor (1996)who shows conditions under which the nature of intermediate input linkages is irrelevant for the volatility of aggregate variables.

The lack of factor substitutability is chie #y responsible for this result.The obvious measure of substitutability of intermediate inputs is the elasticity of substitution between such inputs in the production function.However,for models with intermediate goods trading there is another measure of substituta-bility,namely connectivity.Every good produced in the economy may not be suitable for use as an intermediate input in the production of every other good.Connectivity is used to describe the number of input links the typical sector has with other sectors.A low degree of connectivity,characterized by a sparse input-use matrix,implies few possibilities of substitution among intermediate inputs.

This section explores,through simulation,how disaggregation of K and 'a !ects the volatility of aggregate value added in the general model presented above.Simulations are in order rather than analytical investigations for two distinct reasons.First,as mentioned above,analytical solutions for the model in Section 2are only available for a special case of the parameter set,and second,we are interested in the properties of a nonlinear function of the variables in X R ,namely aggregate value added.

88M.Hor v ath /Journal of Monetary Economics 45(2000)69}106

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脐带间充质干细胞的研究进展 间充质干细胞(mesenchymal stem cells,MSC S )是来源于发育早期中胚层 的一类多能干细胞[1-5],MSC S 由于它的自我更新和多项分化潜能,而具有巨大的 治疗价值 ,日益受到关注。MSC S 有以下特点:(1)多向分化潜能,在适当的诱导条件下可分化为肌细胞[2]、成骨细胞[3、4]、脂肪细胞、神经细胞[9]、肝细胞[6]、心肌细胞[10]和表皮细胞[11, 12];(2)通过分泌可溶性因子和转分化促进创面愈合;(3) 免疫调控功能,骨髓源(bone marrow )MSC S 表达MHC-I类分子,不表达MHC-II 类分子,不表达CD80、CD86、CD40等协同刺激分子,体外抑制混合淋巴细胞反应,体内诱导免疫耐受[11, 15],在预防和治疗移植物抗宿主病、诱导器官移植免疫耐受等领域有较好的应用前景;(4)连续传代培养和冷冻保存后仍具有多向分化潜能,可作为理想的种子细胞用于组织工程和细胞替代治疗。1974年Friedenstein [16] 首先证明了骨髓中存在MSC S ,以后的研究证明MSC S 不仅存在于骨髓中,也存在 于其他一些组织与器官的间质中:如外周血[17],脐血[5],松质骨[1, 18],脂肪组织[1],滑膜[18]和脐带。在所有这些来源中,脐血(umbilical cord blood)和脐带(umbilical cord)是MSC S 最理想的来源,因为它们可以通过非侵入性手段容易获 得,并且病毒污染的风险低,还可冷冻保存后行自体移植。然而,脐血MSC的培养成功率不高[19, 23-24],Shetty 的研究认为只有6%,而脐带MSC的培养成功率可 达100%[25]。另外从脐血中分离MSC S ,就浪费了其中的造血干/祖细胞(hematopoietic stem cells/hematopoietic progenitor cells,HSCs/HPCs) [26, 27],因此,脐带MSC S (umbilical cord mesenchymal stem cells, UC-MSC S )就成 为重要来源。 一.概述 人脐带约40 g, 它的长度约60–65 cm, 足月脐带的平均直径约1.5 cm[28, 29]。脐带被覆着鳞状上皮,叫脐带上皮,是单层或复层结构,这层上皮由羊膜延续过来[30, 31]。脐带的内部是两根动脉和一根静脉,血管之间是粘液样的结缔组织,叫做沃顿胶质,充当血管外膜的功能。脐带中无毛细血管和淋巴系统。沃顿胶质的网状系统是糖蛋白微纤维和胶原纤维。沃顿胶质中最多的葡萄糖胺聚糖是透明质酸,它是包绕在成纤维样细胞和胶原纤维周围的并维持脐带形状的水合凝胶,使脐带免受挤压。沃顿胶质的基质细胞是成纤维样细胞[32],这种中间丝蛋白表达于间充质来源的细胞如成纤维细胞的,而不表达于平滑肌细胞。共表达波形蛋白和索蛋白提示这些细胞本质上肌纤维母细胞。 脐带基质细胞也是一种具有多能干细胞特点的细胞,具有多项分化潜能,其 形态和生物学特点与骨髓源性MSC S 相似[5, 20, 21, 38, 46],但脐带MSC S 更原始,是介 于成体干细胞和胚胎干细胞之间的一种干细胞,表达Oct-4, Sox-2和Nanog等多

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型性格。3.其它:精神分裂症发病与年龄有一定关系,多发生于青壮年,约1/2患者于20~30岁发病。发病年龄与临床类型有关,偏执型发病较晚,有资料提示偏执型平均发病年龄为35岁,其它型为23岁。80年代国内12地区调查资料:女性总患病率(7.07%。)与时点患病率(5.91%。)明显高于男性(4.33%。与3.68%。)。Kretschmer在描述性格与精神分裂症关系时指出:61%患者为瘦长型和运动家型,12.8%为肥胖型,11.3%发育不良型。在躯体疾病或分娩之后发生精神分裂症是很常见的现象,可能是心理性生理性应激的非特异性影响。部分患者在脑外伤后或感染性疾病后发病;有报告在精神分裂症患者的脑脊液中发现病毒性物质;月经期内病情加重等躯体因素都可能是诱发因素,但在精神分裂症发病机理中的价值有待进一步证实。(二)心理社会因素1.环境因素①家庭中父母的性格,言行、举止和教育方式(如放纵、溺爱、过严)等都会影响子女的心身健康或导致个性偏离常态。②家庭成员间的关系及其精神交流的紊乱。③生活不安定、居住拥挤、职业不固定、人际关系不良、噪音干扰、环境污染等均对发病有一定作用。农村精神分裂症发病率明显低于城市。2.心理因素一般认为生活事件可发诱发精神分裂症。诸如失学、失恋、学习紧张、家庭纠纷、夫妻不和、意处事故等均对发病有一定影响,但这些事件的性质均无特殊性。因此,心理因素也仅属诱发因

外阴疾病

外阴疾病 外阴:阴道口外边的外露部分肛门、阴道口及尿道邻近,经常受阴道分泌物及尿液的浸渍,容易发炎。 常见病症:外因瘙痒、外阴炎、外阴白色病变、外因溃疡、外阴癌 外阴疾病 外阴:阴道口外边的外露部分肛门、阴道口及尿道邻近,经常受阴道分泌物及尿液的浸渍,容易发炎。 常见病症:外因瘙痒、外阴炎、外阴白色病变、外因溃疡、外阴癌 外因瘙痒 外阴瘙痒是妇科疾病中很常见的一种症状,外阴是特别敏感的部位,妇科多种病变及外来刺激均可引起瘙痒,使人寝食难安、坐卧不宁。外阴瘙痒多发生于阴蒂、小阴唇,也可波及大阴唇、会阴和肛周 病因:1.慢性局部刺激,外阴、阴道、宫颈炎症的异常分泌物的刺激; 2.外阴不清洁及紧身化纤内裤、卫生巾等致通透不良; 3.外阴寄生虫病,如阴虱、蛲虫、疥疮等; 4.各种外阴皮肤病和外阴肿瘤等; 5.全身性疾病的外阴局部症状,如糖尿病、尿毒症、维生素缺乏等。 症状:外因皮肤瘙痒、烧灼感和疼痛瘙痒部位多生与阴帝、小阴唇、也可波及大阴、会阴、甚至肛周围 危害:(1)性外阴部瘙痒严重时,不但使人坐卧不宁,影响工作、学习、生活和睡眠。 (2)由于女性外阴瘙痒,会影响夫妻生活,所以极有导致夫妻感情不和,严重的 甚至造成感情破裂,婚姻走向终点。 (3)诱发生殖器感染,盆腔炎、肾周炎、性交痛等,日久不愈还可导致多种疾病 同时发生,疾病的危害严重的会危害女性健康,甚至还会造成女性不孕等严重后果。 (4)女性外阴瘙痒严重时,不易根治,易反复,引发早产、胎儿感染畸形等,造 成终身遗憾。 治疗1.外阴涂药

使用有止痒作用的洗剂、膏霜等,如炉甘石洗剂、苯海拉明软膏、皮质醇类软膏等。 2.局部封闭或穴位注药 如皮质醇激素、维生素B12、非那根等。 3.针对病因治疗。 4.预防1. 注意经期卫生,勤清洗。 2.不要冲洗阴道,因为阴道有自清的功能,如果刻意冲洗反而不利 3.忌乱用、烂用药物,忌抓搔及局部摩擦。 4.忌酒及辛辣食物,不吃海鲜等及易引起过敏的药物 6 .久治不愈者应作血糖检查。少吃糖类可避免常常感染霉菌,如少吃淀粉类、糖类以及刺激性的食物(例如酒、辛辣物、油炸类),多吃蔬菜水果类,水份要充足。 5、不穿紧身兜裆裤,内裤更须宽松、透气,并以棉制品为宜。 6.就医检查是否有霉菌或滴虫,如有应及时治疗,而不要自己应用“止痒水”治疗。 8.保持外阴清洁干燥,尤其在经期、孕期、产褥期,每天用女性护理液清洗外阴更换内裤。 9.不穿化纤内裤、紧身裤,着棉织内衣裤。局部坐浴时注意溶液浓度、温度及时间、注意事项。 10.外阴瘙痒者应勤剪指甲、勤洗手,不要搔抓皮肤,以防破溃感染从而继发细菌性感染。 11.上完厕所请记得由前往后擦,因为肛门可能会带来不少细菌,所以如厕后请不要由肛门擦到阴部,才能减少感染的机会。 12.内裤要和其他的衣物分开洗,最好暴晒,可以减少细菌的滋生。如果患有霉菌性阴道炎的话,最好内裤都有热水煮 外阴溃疡外阴溃疡是发生于外阴部的皮肤黏膜发炎、溃烂、缺损。病灶多发生于小阴唇和大阴唇内侧,其次为前庭黏膜及阴道口周围。病程有急性及慢性。 大小阴唇、阴道口周围、阴蒂等处(外阴疾病发展中出现的一个过程,不是一个独立的疾病,有急性和慢性)急性外阴溃疡:非特异性外阴炎病情较轻,多在搔抓之后出现一般比较表浅,但疼痛比较厉害 慢性外阴溃疡:持续时间较长,或者反复发作 癌症引起的溃疡,与结核性溃疡很难鉴别,需做确诊

脐带血造血干细胞库管理办法(试行)

脐带血造血干细胞库管理办法(试行) 第一章总则 第一条为合理利用我国脐带血造血干细胞资源,促进脐带血造血干细胞移植高新技术的发展,确保脐带血 造血干细胞应用的安全性和有效性,特制定本管理办法。 第二条脐带血造血干细胞库是指以人体造血干细胞移植为目的,具有采集、处理、保存和提供造血干细胞 的能力,并具有相当研究实力的特殊血站。 任何单位和个人不得以营利为目的进行脐带血采供活动。 第三条本办法所指脐带血为与孕妇和新生儿血容量和血循环无关的,由新生儿脐带扎断后的远端所采集的 胎盘血。 第四条对脐带血造血干细胞库实行全国统一规划,统一布局,统一标准,统一规范和统一管理制度。 第二章设置审批 第五条国务院卫生行政部门根据我国人口分布、卫生资源、临床造血干细胞移植需要等实际情况,制订我 国脐带血造血干细胞库设置的总体布局和发展规划。 第六条脐带血造血干细胞库的设置必须经国务院卫生行政部门批准。 第七条国务院卫生行政部门成立由有关方面专家组成的脐带血造血干细胞库专家委员会(以下简称专家委

员会),负责对脐带血造血干细胞库设置的申请、验收和考评提出论证意见。专家委员会负责制订脐带血 造血干细胞库建设、操作、运行等技术标准。 第八条脐带血造血干细胞库设置的申请者除符合国家规划和布局要求,具备设置一般血站基本条件之外, 还需具备下列条件: (一)具有基本的血液学研究基础和造血干细胞研究能力; (二)具有符合储存不低于1 万份脐带血的高清洁度的空间和冷冻设备的设计规划; (三)具有血细胞生物学、HLA 配型、相关病原体检测、遗传学和冷冻生物学、专供脐带血处理等符合GMP、 GLP 标准的实验室、资料保存室; (四)具有流式细胞仪、程控冷冻仪、PCR 仪和细胞冷冻及相关检测及计算机网络管理等仪器设备; (五)具有独立开展实验血液学、免疫学、造血细胞培养、检测、HLA 配型、病原体检测、冷冻生物学、 管理、质量控制和监测、仪器操作、资料保管和共享等方面的技术、管理和服务人员; (六)具有安全可靠的脐带血来源保证; (七)具备多渠道筹集建设资金运转经费的能力。 第九条设置脐带血造血干细胞库应向所在地省级卫生行政部门提交设置可行性研究报告,内容包括:

外阴白色病变的症状表现有哪些

外阴白色病变的症状表现有哪些 外阴白色病变是慢性外阴的营养不良。属于营养不良的一种。而这也有分为好几个类型,混合型、增生型和硬化苔藓型等等都是外阴白色病变的类型。 外阴奇痒为主要症状,搔痒时间从发病到治疗有2~3月之内,也有达20 年之久,搔痒剧烈程度不分季节与昼夜,如伴有滴虫性或霉菌性阴道炎,分泌物会更多,局部烧灼感,刺痛与搔痒所致的皮肤粘膜破损或感染有关,局部有不同程度的皮肤粘膜色素减退,常有水肿,皲裂及散在的表浅溃疡。 一、增生型营养不良 一般发生在30~60岁的妇女,主要症状为外阴奇痒难忍,抓伤后疼痛加剧,病变范围不一,主要波及大阴唇,阴唇间沟,阴蒂包皮和后联合处,多呈对称性,病变皮肤增厚似皮革,隆起有皱襞,或有鳞屑,湿疹样改变,表面颜色多暗红或粉红,夹杂有界限清晰的白色斑块,一般无萎缩或粘连。 二、硬化苔藓型营养不良 可见于任何年龄,多见于40岁左右妇女,主要症状为病变区发痒,但一般远较增生型病变为轻,晚期出现性交困难,病变累及外阴皮肤,粘膜和肛周围皮肤,除皮肤或粘膜变白,变薄,干燥易皲裂外,并失去弹性,阴蒂多萎缩,且与包皮粘连,小阴唇平坦消失,晚期皮肤菲薄皱缩似卷烟纸,阴道口挛缩狭窄,仅容指尖。 幼女患此病多在小便或大便后感外阴及肛周不适,外阴及肛周区出现锁孔状珠黄色花斑样或白色病损,一般至青春期时,病变多自行消失。 三、混合型营养不良 主要表现为菲薄的外阴发白区的邻近部位,或在其范围内伴有局灶性皮肤增厚或隆起。 四、增生型或混合型伴上皮非典型增生 一般认为在增生型及混合型病变中,仅5、10例可出现非典型增生,且此非典型增生仅限于增生的上皮细胞部分。非典型增生多无特殊临床表现,局部组织活体组织检查为唯一的诊断方法。但如外阴局部出现溃疡。或界限清楚的白色隆起时,在该处活检发现非典型增生,其癌变的可能性较大。

精神分裂症的发病原因是什么

精神分裂症的发病原因是什么 精神分裂症是一种精神病,对于我们的影响是很大的,如果不幸患上就要及时做好治疗,不然后果会很严重,无法进行正常的工作和生活,是一件很尴尬的事情。因此为了避免患上这样的疾病,我们就要做好预防,今天我们就请广州协佳的专家张可斌来介绍一下精神分裂症的发病原因。 精神分裂症是严重影响人们身体健康的一种疾病,这种疾病会让我们整体看起来不正常,会出现胡言乱语的情况,甚至还会出现幻想幻听,可见精神分裂症这种病的危害程度。 (1)精神刺激:人的心理与社会因素密切相关,个人与社会环境不相适应,就产生了精神刺激,精神刺激导致大脑功能紊乱,出现精神障碍。不管是令人愉快的良性刺激,还是使人痛苦的恶性刺激,超过一定的限度都会对人的心理造成影响。 (2)遗传因素:精神病中如精神分裂症、情感性精神障碍,家族中精神病的患病率明显高于一般普通人群,而且血缘关系愈近,发病机会愈高。此外,精神发育迟滞、癫痫性精神障碍的遗传性在发病因素中也占相当的比重。这也是精神病的病因之一。 (3)自身:在同样的环境中,承受同样的精神刺激,那些心理素质差、对精神刺激耐受力低的人易发病。通常情况下,性格内向、心胸狭窄、过分自尊的人,不与人交往、孤僻懒散的人受挫折后容易出现精神异常。 (4)躯体因素:感染、中毒、颅脑外伤、肿瘤、内分泌、代谢及营养障碍等均可导致精神障碍,。但应注意,精神障碍伴有的躯体因素,并不完全与精神症状直接相关,有些是由躯体因素直接引起的,有些则是以躯体因素只作为一种诱因而存在。 孕期感染。如果在怀孕期间,孕妇感染了某种病毒,病毒也传染给了胎儿的话,那么,胎儿出生长大后患上精神分裂症的可能性是极其的大。所以怀孕中的女性朋友要注意卫生,尽量不要接触病毒源。 上述就是关于精神分裂症的发病原因,想必大家都已经知道了吧。患上精神分裂症之后,大家也不必过于伤心,现在我国的医疗水平是足以让大家快速恢复过来的,所以说一定要保持良好的情绪。

外阴白色病变的检查诊断方法是什么

外阴白色病变的检查诊断方法是什么 外阴奇痒是外阴白色病变的主要症状,搔痒时间从发病到治疗有2~3月之内,也有达20年之久,搔痒剧烈程度不分季节与昼夜。专家提示,一旦发现自己有类似于外阴白色病变的这种,应立即到医院进行确诊。早期的诊断及治疗对我们早日恢复健康并且尤为重要。 外阴白色病变的检查: 多点活检送病理检查,确定病变性质,排除早期癌变,活检应在有皲裂,溃疡,隆起,硬结或粗糙处进行,为做到取材适当,可先用1%甲苯胺蓝(toluidine blue)涂病变区,待白干后,再用1%醋酸液擦洗脱色,凡不脱色区表示该处有裸核存在,提示在该处活检,发现非典型增生或甚至癌变的可能性较大,如局部破损区太广,应先治疗数日,待皮损大部愈合后,再选择活检部位以提高诊断准确率。 外阴白色病变的诊断: 1、症状判断:外阴白斑一般根据症状就可以判断,比如,外阴局部粘 膜发白,瘙痒、粗糙、脱屑等现象的出现,都会诊断为外阴白斑,当然,外阴白斑有很多的类型,如果外阴白斑属于增生型,也就是说局部的皮肤粘膜增厚了,弹性变差了,而且也出现了相应的溃疡等不适症状。这是主要的外阴白斑的诊断方法。 2、细胞活检:有时外阴白斑的诊断需要进一步的做细胞活检,观察有 没有癌细胞,以便于确诊。活检病理检查确定病变性质,排除早期癌变。活检应在有皲裂溃疡、隆起、硬结或粗糙处进行为做到取材适当,外阴白斑的诊断方法可先用1%甲苯胺蓝涂病变区,待白干后再用1%醋酸液擦洗脱色。凡不脱色区表示该处有裸核存在,提示在该处活检发现非典型增生或甚至癌变的可能性较大。如局部破损区太广,应先治疗数日待皮损大部愈合后,再选择活检部位以提高诊断准确率。 3、病理诊断依据:除了解疾病的主要临床症状外,还应对疾病的发病 机理有一定的认识,因为导致外阴白斑皮肤瘙痒及色素的减退或脱色的疾病有很多种,不只是外阴白斑一种,它们的表现虽有些不同,但用肉眼不易区别开来,所以当遇到外阴有病损不典型或慢性皲裂、局限性增厚、溃破等症状的患者时,必须依靠活组织病理检查确诊。

精神分裂症的病因是什么

精神分裂症的病因是什么 精神分裂症是一种精神方面的疾病,青壮年发生的概率高,一般 在16~40岁间,没有正常器官的疾病出现,为一种功能性精神病。 精神分裂症大部分的患者是由于在日常的生活和工作当中受到的压力 过大,而患者没有一个良好的疏导的方式所导致。患者在出现该情况 不仅影响本人的正常社会生活,且对家庭和社会也造成很严重的影响。 精神分裂症常见的致病因素: 1、环境因素:工作环境比如经济水平低低收入人群、无职业的人群中,精神分裂症的患病率明显高于经济水平高的职业人群的患病率。还有实际的生活环境生活中的不如意不开心也会诱发该病。 2、心理因素:生活工作中的不开心不满意,导致情绪上的失控,心里长期受到压抑没有办法和没有正确的途径去发泄,如恋爱失败, 婚姻破裂,学习、工作中不愉快都会成为本病的原因。 3、遗传因素:家族中长辈或者亲属中曾经有过这样的病人,后代会出现精神分裂症的机会比正常人要高。 4、精神影响:人的心里与社会要各个方面都有着不可缺少的联系,对社会环境不适应,自己无法融入到社会中去,自己与社会环境不相

适应,精神和心情就会受到一定的影响,大脑控制着人的精神世界, 有可能促发精神分裂症。 5、身体方面:细菌感染、出现中毒情况、大脑外伤、肿瘤、身体的代谢及营养不良等均可能导致使精神分裂症,身体受到外界环境的 影响受到一定程度的伤害,心里受到打击,无法承受伤害造成的痛苦,可能会出现精神的问题。 对于精神分裂症一定要配合治疗,接受全面正确的治疗,最好的 疗法就是中医疗法加心理疗法。早发现并及时治疗并且科学合理的治疗,不要相信迷信,要去正规的医院接受合理的治疗,接受正确的治 疗按照医生的要求对症下药,配合医生和家人,给病人创造一个良好 的治疗环境,对于该病的康复和痊愈会起到意想不到的效果。

卫生部办公厅关于印发《脐带血造血干细胞治疗技术管理规范(试行)

卫生部办公厅关于印发《脐带血造血干细胞治疗技术管理规 范(试行)》的通知 【法规类别】采供血机构和血液管理 【发文字号】卫办医政发[2009]189号 【失效依据】国家卫生计生委办公厅关于印发造血干细胞移植技术管理规范(2017年版)等15个“限制临床应用”医疗技术管理规范和质量控制指标的通知 【发布部门】卫生部(已撤销) 【发布日期】2009.11.13 【实施日期】2009.11.13 【时效性】失效 【效力级别】部门规范性文件 卫生部办公厅关于印发《脐带血造血干细胞治疗技术管理规范(试行)》的通知 (卫办医政发〔2009〕189号) 各省、自治区、直辖市卫生厅局,新疆生产建设兵团卫生局: 为贯彻落实《医疗技术临床应用管理办法》,做好脐带血造血干细胞治疗技术审核和临床应用管理,保障医疗质量和医疗安全,我部组织制定了《脐带血造血干细胞治疗技术管理规范(试行)》。现印发给你们,请遵照执行。 二〇〇九年十一月十三日

脐带血造血干细胞 治疗技术管理规范(试行) 为规范脐带血造血干细胞治疗技术的临床应用,保证医疗质量和医疗安全,制定本规范。本规范为技术审核机构对医疗机构申请临床应用脐带血造血干细胞治疗技术进行技术审核的依据,是医疗机构及其医师开展脐带血造血干细胞治疗技术的最低要求。 本治疗技术管理规范适用于脐带血造血干细胞移植技术。 一、医疗机构基本要求 (一)开展脐带血造血干细胞治疗技术的医疗机构应当与其功能、任务相适应,有合法脐带血造血干细胞来源。 (二)三级综合医院、血液病医院或儿童医院,具有卫生行政部门核准登记的血液内科或儿科专业诊疗科目。 1.三级综合医院血液内科开展成人脐带血造血干细胞治疗技术的,还应当具备以下条件: (1)近3年内独立开展脐带血造血干细胞和(或)同种异基因造血干细胞移植15例以上。 (2)有4张床位以上的百级层流病房,配备病人呼叫系统、心电监护仪、电动吸引器、供氧设施。 (3)开展儿童脐带血造血干细胞治疗技术的,还应至少有1名具有副主任医师以上专业技术职务任职资格的儿科医师。 2.三级综合医院儿科开展儿童脐带血造血干细胞治疗技术的,还应当具备以下条件:

妇科良方_第二章 外阴白色病变及外阴瘙痒症方

外阴白色病变方 外阴白色病变包括由于各种因素影响所致之外阴部皮肤及粘膜的不同程度变白及(或)粗糙、萎缩的状态。1975年国际外阴病研究会改称“外阴白斑”为“慢性外阴营养不良”,并根据其组织病理变化的不同而分为增生型营养不良(包括无非典型增生、非典型增生两类)、硬化苔藓型营养不良、混合型营养不良(亦包括无非典型增生、非典型增生两类)三种类型。 外阴瘙痒为本病主要症状,搔抓可造成局部破溃与感染而出现烧灼感、疼痛、流液。增生型皮肤增厚似皮革,粗糙,或有鳞屑、湿疹样改变,表面颜色多暗红或粉红,夹杂有界限清晰的白色斑块;硬化苔藓型皮肤或粘膜变白变薄,甚至裂开,阴道口萎缩者可致性交痛;混合型是在外阴萎缩的基础上又有增厚的斑块或疣状增生灶。各型均以病检为主要诊断依据。 西医治疗可内服维生素A、B2、B6、鱼甘油等;局部用药以止痒、消炎、润肤和改善局部营养为目的,用药应依据病理类型。如增生型可用肤轻松、氢化可的松等软膏涂擦;硬化苔藓型给予1~2%丙酸睾丸酮鱼甘油软膏;混合型则用丙酸睾素软膏与可的松软膏合用或先后使用。氦氖激光照射对外阴硬萎有一定疗效。 本病一般属中医“阴痒”、“阴蚀”等病证范畴。其发病机理,常因肝肾阴血不足,不能滋养阴器,血虚生风化燥,而致阴部奇痒难忍;或因脾气亏虚,一则气虚血少,不能滋养阴部,脾虚又可生湿,流注于下,形成气血不足而湿浊停滞的虚实夹杂局面;或因湿热内盛,热蕴阴部肌肤而致阴痒阴肿;久病入络,气血运行不畅而成瘀滞,与湿浊相互胶结,而见苔癣、奇痒、干裂诸候,且经久难愈。治疗当结合病因病机,或滋养肝肾,养血熄风止痒;或清热利湿,祛风止痒;或活血化瘀软坚;或健脾祛湿杀虫等。 本节选介消斑膏丸方、蛇桑坐浴方等治疗外阴白色病变验方共13首。 1.消斑膏丸方 【药物组成】①外用消斑膏:A、消斑膏1号:补骨脂、仙灵脾各9g,生狼毒、白藓皮各6g,蛇床子、徐长卿各15g,薄荷1g。用其酒精渗出液,回收浓缩后,制成霜剂;B、消斑膏2号:即1号去薄荷,加0.1%强的松粉拌匀而成(制法同上);C、消斑膏3号:即1号去狼毒、薄荷,加白花蛇舌草、一枝黄花各30g(制法同上);D、消斑膏4号:即1号去薄荷加丙酸睾丸酮做成0.2%的霜剂(制法同上)。 ②内服消斑丸:黄芪、丹参、当归、菟丝子、仙灵脾、白蒺藜各3g,白藓皮4g,木香 0.2g。共研细末,做成蜜丸或煎成汤剂(以上为1日量)。 【治疗方法】①外用消斑膏:1号适用于外阴无破溃或皲裂者;2号适用于对1号有过敏反应但无癌变可能者;3号适用于局部有感染、破溃或皲裂,或有霉菌,滴虫感染者;4号适用于外阴萎缩或有粘连者。 以上软膏均每日外涂阴部1~2次。 ②内服消斑丸:每日2次,每次10g。所有病例均服此丸。 膏剂外用和丸剂内服,均以3个月为1疗程。一般用药1~3个疗程。

精神分裂症应该怎么治疗

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脐带血间充质干细胞的分离培养和鉴定 【摘要】目的分离培养脐带血间充质干细胞并检测其生物学特性。方法在无菌条件下用密度梯度离心的方法获得脐血单个核细胞,接种含10%胎牛血清的DMEM培养基中。单个核细胞行贴壁培养后,进行细胞形态学观察,绘制细胞生长曲线,分析细胞周期,检测细胞表面抗原。结果采用Percoll(1.073 g/mL)分离的脐血间充质干细胞大小较为均匀,梭形或星形的成纤维细胞样细胞。细胞生长曲线测定表明接后第5天细胞进入指数增生期,至第9天后数量减少;流式细胞检测表明50%~70%细胞为CD29和CD45阳性。结论体外分离培养脐血间充质干细胞生长稳定,可作为组织工程的种子细胞。 【关键词】脐血;间充质干细胞;细胞周期;免疫细胞化学 Abstract: Objective Isolation and cultivation of mesenchymal stem cells (MSCs) in human umbilical cord in vitro, and determine their biological properties. Methods The mononuclear cells were isolated by density gradient centrifugation from human umbilical cord blood in sterile condition, and cultured in DMEM medium containing 10% fetal bovine serum. After the adherent mononuclear cells were obtained, the shape of cells were observed by microscope, then the cell growth curve, the cell cycle and the cell surface antigens were obtained by immunocytochemistry and flow cytometry methods. Results MSCs obtained by Percoll (1.073 g/mL) were similar in size, spindle-shaped or star-shaped fibroblasts-liked cells. Cell growth curve analysis indicated that MSCs were in the exponential stage after 5d and in the stationary stages after 9d. Flow cytometry analysis showed that the CD29 and CD44 positive cells were about 50%~70%. Conclusions The human umbilical cord derived mesenchymal stem cells were grown stably in vitro and can be used as the seed-cells in tissue engineering. Key words:human umbilical cord blood; mesenchymal stem cells; cell cycle; immunocytochemistry 间充质干细胞(mesenchymal stem cells,MSCs)在一定条件下具有多向分化的潜能,是组织工程研究中重要的种子细胞来源。寻找来源丰富并不受伦理学制约的间充质干细胞成为近年来的研究热点[1]。脐血(umbilical cord blood, UCB)在胚胎娩出后,与胎盘一起存在的医疗废物。与骨髓相比,UCB来源更丰富,取材方便,具有肿瘤和微生物污染机会少等优点。有人认为脐血中也存在间充质干细胞(Umbilical cord blood-derived mesenchymal stem cells,UCB-MSCs)。如果从脐血中培养出MSCs,与胚胎干细胞相比,应用和研究则不受伦理的制约,蕴藏着巨大的临床应用价值[2,3]。本研究将探讨人UCB-MSCs体外培养的方法、细胞的生长曲线、增殖周期和细胞表面标志等方面,分析UCB-MSCs 作为间充质干细胞来源的可行性。

我的精神分裂症形成和发展史

出生前背景 母亲是地道、淳朴、专一,文化程度不高的农村主妇,父亲是当地的混混,好色成性,道德观念淡薄,无责任感,为非作歹,攻击性强,专横,常聚众斗殴,浪荡无比。他的放荡从和母亲接姻前持续到今。从母亲断断断断续的回忆中我恍知我没呱呱落地前就已有不寻常的经历,失职的母亲怀着我和父亲怄气经常绝食威胁,奢望唤醒父亲的为父为夫的责任感。可怜的女人,痴痴的等待,身心俱损终换不来一时的真爱。他从不掩饰自己的劣迹,而是将其当作显示自己无限魅力和能耐的招牌加以渲染,毫无顾忌在当众谈论。 童年背景 除父母,还有两兄,我是幼女,相比较受宠爱。 爷爷 奶奶,传统的封建妇女,极重男轻女,从未给过我好脸色。爷爷、奶奶在家中居从属地位,对我没产生至关重要的影响。 儿时家里很穷,主要靠母亲支撑维系家族。她非常辛苦,在纺织厂,三班制。歇工还要步行到七八公里外的田地里劳作。很难照顾到我们的感受,她所能做的就是竭尽所能维系家庭的完整,让我们能生存下去。与此同时,她还要忍受父亲周而复始的背叛,虐待、暴打。生活不如意加之贫困无比,让她难免脾气暴躁,我是她时常爆发时的接纳对象。如此妇女,受封建思想灌输至深,永远铭记自己要恪守妇道,她始终如一的忠诚与父亲,永不离弃他,爱护他,疼爱他(她比父亲年长些,父亲相貌俊秀,而母亲姿色平平)。我可怜而鄙视她,丈夫如果某天一改往日作贱她的口吻,她会像孩子似的受宠若惊的心花怒放。 父亲霸道无比,家里人人惧怕他,他无比自恋。除了母亲,伤害最深的是大哥,每天无缘无故的遭受父亲的暴打。他性情多变,无法揣摩,吃饭时一家人欢声笑语,吃完饭看看大哥不顺眼他操起皮鞭就抽。看到大哥在皮鞭下嚎哭,新的皮鞭疤痕烙在旧疤痕上,我和二哥感到恐惧,怜悯大哥,然而我们是无助的,谁也不能阻挡皮鞭的落下。尽管如此,父亲当时在我心目中是高大的,令人崇拜的,对我产生的正负影响也是最强烈的。他多才多艺,知识渊博,开明,前卫,聪明,而母亲相比之下平庸很多,她每天只是起早贪黑的工作,思想保守,愚昧,无任何才华而言。 童年,虽说不是幸福的,但也算不上痛苦。 童年转青春期阶段 邻居是一个恶老太婆,和当时大多传统村妇一样,没知识、没修养也没教养。她确实很恶,不允许她看不顺眼的小孩从她家旁边的小巷经过,她不喜欢我。每次我冒险经过她都会如同恶狗样在我刚出现在她视野中就开始狂吠,连同我的老祖宗也一起骂,持续到我再次从原路返回,躲到家里,她的吠声还要延续十分钟。 被爱妄想出现在五年级,应该更早些。我喜欢上一个家境优越的的男生,尽管那时他已经有“女朋友”。从爱上他那刻起我就很明确他也是爱我的,他和同桌说话其实余光是在看我,尽管没有任何证实,我非常明确他就是偷偷看我的。即使在上课,即使他没有和同桌说话,我感觉他在狠狠的想着我。他回答老师的提问也暗示着对我的爱意。比如他的回答里有“她”,那就是暗示他说的是我。或是我读书看到书上的“他”字样,心便狂喜的乱跳,认为这是我暗恋对象给我的暗示,他一直在我身边! 妄想形成初期就有泛化倾向,我似乎对自己相貌无限自信,觉得自己是最美的,一上街满街的男孩都为我的美貌所折服,他们都不由自主的盯着我看,我的一举一动都被他们密切关注着,一出门便有那么多双眼睛注视着我。

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