Vanoxerine dihydrochloride_67469-78-7_DataSheet_MedChemExpress

Product Name:

Vanoxerine dihydrochloride CAS No.:

67469-78-7Cat. No.:

HY-13217Product Data Sheet

MWt:

450.56Formula:

C28H32F2N2O Purity :>98%

Solubility:DMSO

Mechanisms:

Biological Activity:

Vanoxerine 2 Hcl(GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).

Pathways:Neuronal Signaling; Target:Dopamine reuptake inhibitor ()p (p p )

IC50 value:

Target: Dopamine reuptake inhibitor At a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[14] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine. Vanoxerine is a potentially effective treatment for cardiac arrhythmias. A significant cause of cardiac arrhythmias is reentry, an

l t h i l i t i hi h th lif ti i l th t f t t i t d d t References:

[1]. Lacerda AE, et al. Vanoxerine: cellular mechanism of a new antiarrhythmic. J Cardiovasc

Electrophysiol. 2010 Mar;21(3):301-10.[2]Mahmud F et al Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue electrophysiologic event in which the proliferating signal that refuses to terminate, and endures to reexcite the heart after the refractory period....

[2]. Mahmud F, et al. Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue.

Chaos. 2011 Jun;21(2):023121.Caution: Not fully tested. For research purposes only

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