EVP-6124 hydrochloride_550999-74-1_DataSheet_MedChemExpress

Product Name:

EVP-6124 hydrochloride CAS No.:

550999-74-1Cat. No.:

HY-15430A Product Data Sheet

MWt:

357.30Formula:

C16H18Cl2N2OS Purity :>98%

Solubility:

DMSO

Mechanisms:Biological Activity:

EVP-6124Hcl is a novel partial agonist of 7neuronal nicotinic acetylcholine receptors (nAChRs)

Pathways:Membrane Tranporter/Ion Channel; Target:nAChR Pathways:Neuronal Signaling; Target:nAChR EVP-6124 Hcl is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).EVP-6124 showed selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2

nAChRs.

IC50 value:

Target: α7 nAChR EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to

enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals with memory References:

[1]. Prickaerts J, van Goethem NP, Chesworth R et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the

acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012disorders such as Alzheimer's, to be required to activate the receptor. In this scenario, research demonstrated that memory deficits can be minimized or entirely reversed by controlling the neuronal channel with EVP-6124 alone or in combination with other Al...

y p y p p gy

Feb;62(2):1099-110.

[2]. In development for Alzheimer disease and schizophrenia Caution: Not fully tested. For research purposes only

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