Nuclear_factor_kappa-light-chain-enhancer_of_activated_B_cells抑制剂_激动剂_MCE

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells Array

NF-κB (nuclear factor kappa-light-chain-enhancer of activated

B cells) is a protein complex that controls transcription of DNA.

NF-κB is found in almost all animal cell types and is involved in

cellular responses to stimuli such as stress, cytokines, free radicals,

ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.

NF-κB plays a key role in regulating the immune response to

infection. Incorrect regulation of NF-κB has been linked to

cancer, inflammatory, and autoimmune diseases, septic shock, viral

infection, and improper immune development. NF-κB has also

been implicated in processes of synaptic plasticity and memory. There

are five proteins in the mammalian NF-κB family:

NF-κB1, NF-κB2, RelA, RelB, c-Rel.

NF-κB Inhibitors & Modulators

CID-2858522 selectively inhibits the NF-(kappa)B pathway (IC50 <0.1 (mu)M for PMA-stimulated IL-8 production) induced by PKC,operating downstream of PKC but upstream of IKKbeta, without Didox is a strong inhibitor of ribonucleotide reductase (RR) that

interferes with DNA synthesis and repair by blocking the production of deoxyribonucleotides and has demonstrated antitumor effects for Emodin is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of Lipoic acid inhibits activation of nuclear factor kappa-B, which is Parthenolide (PTL) is a sesquiterpene lactone which can induce Parthenolide can deplete HDAC1 protein without affecting other PNRI-299 is a selective AP-1 transcription inhibitor with IC50 of 20uM without affecting NF-kappaB transcription (up to 200 uM) or Email: sales@https://www.360docs.net/doc/c016631937.html,

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Sodium salicylate is a metabolite of acetylsalicylic acid, and functions Triptolide is a diterpene triepoxide, immunosuppresive agent Cat. No.: HY-B0167A

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