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The_Dissemination_of_Intangible_Cultural_Heritage_

The_Dissemination_of_Intangible_Cultural_Heritage_

Cultural and Religious Studies, May 2023, Vol. 11, No. 5, 241-245doi: 10.17265/2328-2177/2023.05.005 The Dissemination of Intangible Cultural Heritage AlongBeijing-Hangzhou Canal Based on Encoding/Decoding Theory *TAN Hao, XIANYU JingBeijing Union University, Beijing, ChinaThe Beijing-Hangzhou Grand Canal carries a wealth of Chinese cultural symbols, showing the lifestyle and wisdomof working people through ages. The preservation and inheritance of its intangible cultural heritage can help to evokecultural memories and cultural identification of the Canal and build cultural confidence. This paper applies StuartHall’s encoding/decoding theory to analyze the dissemination of intangible heritage tourism culture. On the basis ofa practical study of the villages along the Beijing-Hangzhou Grand Canal, this paper analyses the problems in thetransmission of its intangible cultural heritage and proposes specific methods to solve them in four processes,encoding, decoding, communication, and secondary encoding, in order to propose references for the transmission ofintangible heritage culture at home and abroad.Keywords: dissemination, encoding, decoding, intangible cultural heritageIntroductionThe Beijing-Hangzhou Grand Canal was built during the Spring and Autumn Period, and it has a history of more than 2,500 years. With a total length of about 1,797 kilometers, it is a historical treasure that is closely related to the lifestyle of working people and traditional Chinese culture, including traditional music, traditional dance, traditional painting, traditional skills, etc. For many reasons, the Canal’s intangible cultural heritage (ICH) has not yet been effectively inherited and disseminated, and it is also in danger of being lost. Stuart Ha ll’s encoding/decoding theory model is able to break away from the shackles of subject-object linear transmission of culture communication, and view the process of ICH transmission from the perspective of encoding-communication-decoding. The study of the ICH tourism culture circulation through encoding and decoding theory has both practical and historical significance.Method for StudyStuart Hall argues that discourse is like a commodity that goes through the four stages of production, circulation, consumption, and reproduction described by Marxism (Chen & Lin, 2014), and suggests that individuals may resist or negotiate on the dissemination of an ideology (Evan, 2015). China is rich in ICH, but if it is not disseminated, the preservation of heritage would become completely impotent. As Foucault put it, “criticism” is one of the circulation mechanisms for knowledge to release its power (Claudia & Donna, 2021). * This paper is supported by the National Social Science Fund Project (No. 20BH151).TAN Hao, post-graduate student, College of Applied Science and Technology of Beijing Union University, Beijing, China. XIANYU Jing (corresponding author), Ph.D., Associate Professor, Tourism College of Beijing Union University, Beijing, China.DA VID PUBLISHINGDTHE DISSEMINATION OF INTANGIBLE CULTURAL HERITAGE242Wu (2007) points out that cultural communication is both a social phenomenon and a fundamental part of tourism destination marketing, and the transmission of information is also an important form of tourism service.The transmission of ICH tourism culture goes through three stages: encoding, communication, and decoding. The encoding process refers to the production of ICH tourism products, which emphasizes modern artistic processing while preserving the authenticity of ICH and presenting in a way that is pleasing to the audience. The Grand Canal ICH is not only an indispensable part of canal cultural heritage, but also a potential tourism resource for tourist destination development (Zhang, 2020). The communication process of ICH is to disseminate the encoded ICH information to the audience via various forms. In this process, the discourse of ICH is not a closed system, but consists of topics, treatments, issues, and events (Zou, 2014). The decoding process of ICH means that after the audience receives the ICH discourse, they decode the ICH elements in it according to their own cognition. In view of the decoders’different attitudes when they are decoding the symbolic meanings, Hall applies three scenarios to describe the three positions of the audience in the decoding process, namely, the dominant position, the negotiated position, and the confrontational position. The decoding process of ICH requires mutual feedback between encoding and decoding processes, in order to achieve good communication effects, and the secondary encoding is needed when necessary.FindingsLack of EncoderAt present, most of villages of the Grand Canal have not paid much attention to the cultivation of the ICH inheritors, and some masters of art have passed away, the problem of their aging being serious, and some kinds of ICH are facing the dilemma of no one to encode it, such as Work Song of Boatmen, Woodcut New Year Pictures. Fewer ICH tourism products are encoded for international tourists, resulting in the weakness of international dissemination. In encoding stage, important issues that need to be solved are how to keep the authenticity of traditional ICH while keeping up with the times, and how to extract potential ICH in each section of the Beijing-Hangzhou Grand Canal that can show the geographical characteristics and highlight the uniqueness of the Grand Canal ICH.Being Poor in Communication EffectThe current dissemination of the Canal ICH is facing the problems of monotonous communication channel and weak interaction with the audience. According to the investigation, three reasons lead to these problems: Firstly, there is a lack of derivative products from the reprocessing and re-creation of ICH elements in tourism products or tourist attractions, resulting in tourists’ unclear concept of intangible cultural heritage (Haleh, Mohammad, & Neda, 2019) and lack of proper ways to deeply understand ICH elements. Secondly, most of the ICH products are not targeted for different groups or through various channels when they are sold or exhibited, resulting in the weakness of dissemination. Third, there are few channels for communication and interaction between the encoders and decoders, and the weak interaction between decoders and encoders may lead to the insufficient understanding of ICH elements by decoders. The communication channel of ICH for the international public still remains in the traditional way of TV media, so it is difficult for the international public to receive the symbols containing Chinese ICH.Decoders’ Hardness to Stand in Dominant PositionFrom the perspective of decoding effect, the decoding of ICH in tourism products or tourism performancesTHE DISSEMINATION OF INTANGIBLE CULTURAL HERITAGE243in China generally suffers from the problem that the audience decoding the ICH is difficult to be in a dominant position (Guo & Wang, 2019). The main reason is that most kinds of ICH have its unique regional characteristics, but the audience lacks a certain understanding of ICH with local characteristics due to the limitations of geographic space and decoders’ background knowledge. This will lead to deviations in their understanding of the connotations and values expressed by ICH elements in tourism products or performances. Secondly, the encoder will artistically create the ICH elements in tourism products or performances, while the decoder has a subjective understanding of the ICH elements in tourism products or performances due to their prior knowledge level and acceptability, which would lead to unsatisfactory communication effect. Thirdly, the audience’s understanding of ICH is not fed back to the encoder through effective channels, or the encoder does not pay enough attention to the feedback and lacks targeted secondary encoding, which makes it difficult for the audience to be in a dominant position in the decoding process.SolutionsEncoding: Inherit and Innovate Encoding Models, Educating EncoderIn this process, we should enhance the innovation of the encoding mode for ICH tourism products.The first is to innovate the expression of the theme symbol of tourism products. Although ICH itself is intangible, it can be transmitted by means of physical ICH cultural products, which requires the encoder to have an objective and accurate understanding of the ICH involved in the product and avoid the subjective elements being blindly planted into it by the encoder.Second, we should use symbols carrying meaning to transmit these codes innovatively. In the encoding process of ICH tourism products, the encoder should first clarify the thematic direction of the products, combine various carriers for transmitting symbols such as visual transmission or audio transmission, incorporate emerging technologies and equipment into the encoding process, and encode ICH suitable for different types of people, so as to achieve the best effect when transmitting symbols. Focusing on the excavation of potential ICH, the production process of ICH products can help to awaken the non-physical cultural memory of tourists and evoke their cultural memory and cultural identity. In this process, it is more important to excavate the discourse of potential ICH than simply disseminate the textual symbols.In addition, there is a need to focus on the cultivation and education of intangible heritage inheritors. Most living ICH masters are old, and if their skills are not inherited, it will cause irreparable loss of intangible cultural heritage (Qi, 2006). The cooperation with local secondary schools or universities to set up special courses on intangible heritage culture will promote the inheritance of ICH.In addition to hiring traditional talents of ICH, attention should be paid to finding modern talents who master emerging technologies and understand the frontiers of culture so as to achieve the integration of traditional culture and modern technology at the encoding process. It can systematically cultivate multi-talented ICH encoders who are dialectically unified between tradition and modernity, thus highlighting the core of ICH at the encoding stage. Communication: Broaden Communication Channels & Refine Communication Content The ways for ICH dissemination are still traditional and backward at present, and we should try to present and spread brilliant ICH of the Canal. Performing a series of arts activities and festivals in tourist destinations and uploading them to the Internet platform can surely evoke people’s cultural memories and make them identify with the ICH. In this process, attention should be paid to breaking the barrier between different regions, andTHE DISSEMINATION OF INTANGIBLE CULTURAL HERITAGE244harmonizing the relationship between regional characteristics of ICH and internationalization of its content to disseminate ICH abroad. We can also make documentary or online videos, spread coded cultural symbols on media platforms for foreigners, and concentrate on the follow-up work after the dissemination. To avoid aberrant decoding, it is important to consider what is missed or may misguide people in the description of ICH during dissemination, as mass travelers mainly rely on advertisements or brochures to learn about their tourist destinations, and they do not realize that they may subvert the stereotypes. Therefore, the description of ICH is equally crucial in this context (Ira, 1993).Decoding: Increase the Depth of Traveler Participation & Prevent Decoding Mismatches In order to achieve a better circulation effect, the audience’s decoding of the ICH should be oriented to the dominant position. In the dominant position, the decoder can accurately understand the meaning expressed by the Grand Canal ICH performance encoder and can maintain the same understanding of ICH with the encoder. The authenticity of the ICH performance connects encoder and tourists in their spirit, thus seeking deep integration and promoting the cultural identification of the tourists (Miguel, 2008). Experiential ICH tourism allows decoders to participate in ICH tourism actively, shifting decoders in negotiated position or confrontational position to the dominant position. At present, the participatory and experiential aspects of canal ICH tourism products are generally not well enough, tourists basically appreciating them passively. Therefore, we should promote the development of experiential ICH tourism products to integrate touring, entertainment, experience, and learning through engagement, connection, and creation, so as to enhance the participation, interaction, knowledge, and fun of the Grand Canal ICH tourism process and enter into a shared ritualized field (Han, 2014). Secondary Encoding: Collect Feedback & Enhance Consumer StickinessSecondary encoding seems to be a feedback process that may be neglected by the encoders at the end of the circulation, but it is actually significant. In the ICH tourism circulation, some traditional customs of the Canal like Fisherman’s Wedding Ceremony or Sacrifice to the River God are quite ritualistic but it may bring a sense of distance and strangeness to the decoder at the same time. ICH tourism should not only focus on the mode of transmission, but also on the interaction and the feedback of audience (Zhou & Zhang, 2022). Encoders need to focus on post-communication feedback when facing mismatch that occurs between the encoder and the decoder, so as to improve the quality of secondary encoding. In the late stage of circulation, establishing a reasonable feedback mechanism is an urgent issue to be solved, and only when the feedback is really received by the encoder can the secondary encoding be improved. Before the ICH performance, the encoder can design a questionnaire according to its theme, and when the audience enters, the staff distributes the questionnaire to them and collects the feedback from the audience, and then carefully sorts out the feedback. Then the encoders reflect on the results and transform the feedback into the ideas of secondary encoding. Through some new and popular ways such as social media, surveys, or prize quizzes, to keep abreast of the audience’s thoughts and preferences for ICH products. In this way, it is possible to verify the dissemination of encoder’s pre-determined meaning of the ICH symbols after the communication process. So that the understanding of the decoder will be consistent with the encoder’s original intention, and the decoder is always in the dominant position, and thus the dissemination effect can be maximized. The secondary encoding experience of other cultural products also can be used for reference in the development of derivatives and enhancement of consumers’ stickiness. On the basis of catering to decoders’preferences, combining with aspects of decoders’ daily life and online platforms, we can disseminate the encoded ICH symbols into all aspects of decoder’s life.THE DISSEMINATION OF INTANGIBLE CULTURAL HERITAGE245ConclusionThe Grand Canal culture has a long history, and various kinds of ICH with regional characteristics record the way of Chinese lifestyle for thousands of years. By analyzing the dissemination of ICH along the Beijing-Hangzhou Grand Canal with Stuart Hall’s encoding/decoding theory, we can find that the transmission of its ICH is suffering from the lack of encoder, poor communication effect, and the decoders’ hardness to stand in the dominant position. In the encoding stage, ICH circulation should focus on the inheritance, the cultivation of ICH encoders, and the encoding of tourism cultural products. In the communication stage, it should broaden the dissemination channels and refine the contents. In the decoding stage, it should increase the participation of decoders to prevent decoding mismatch and collect feedback from decoders to improve the secondary encoding quality. We should improve the universality and accuracy of ICH in terms of encoding, communication, decoding, and secondary encoding with the help of its immaterial attributes, use modern technology and diversified ways to inherit ICH with its historical connotation, so that decoders are in the dominant position to make ICH of the Canal better inherited and developed.ReferencesChen, L. D., & Lin, Y. F. (2014). Inheritance and innovation: A study of Stuart Hall’s masterpiece Encoding/Decoding. Journalism & Communication, 21(8), 99-112.Claudia, M., & Donna, D. (2021). The construction of intangible cultural heritage: A Foucauldian critique. Annals of Tourism Research, 89(1), 1-11.Evan, L. K. (2015). Using social scientific criteria to evaluate cultural theories: Encoding/decoding theory. KOME, 22(1), 10-26. Guo, X. R., & Wang, N. (2019). Research on the strategy for video transmission of intangible cultural heritage in China from the perspective of coding and decoding theory—Case study of the story of Yanxi Palace. Cultural Industry Research, 2(1), 123-134.Haleh, M., Mohammad, M., & Neda, T. F. (2019). A study on t ourists’ tendency toward intangible cultural heritage as an attraction (Case study: Isfahan, Iran). City, Culture and Society, 17(1), 54-60.Han, B. Y. (2014). The development model of Rizhao intangible cultural heritage from the perspective of tourism. China Journal of Commerce, 20(1), 184-185.Ira, S. (1993). Marketing authenticity in third world countries. Annals of Tourism Research, 20(1), 302-318.Miguel, V. G. (2008). Intangible heritage tourism and identity. Tourism Management, 39(1), 807-810.Qi, Q. F. (2006). Study on the transmission and inheritors in the protection of intangible cultural heritage. Journal of Northwestern Ethnic Studies, 3(1), 114-123.Wu, N. (2007). Information dissemination: A key link in the marketing and service of tourist destinations. Tourism Tribune, 10(1), 67-70.Zhang, B. F. (2020). Study on the interactive model of intangible cultural heritage protection and tourism development in Beijing-Hangzhou Canal. Gansu Theory Research, 1(1), 103-109.Zhou, K., & Zhang, Y. (2022). The function and path of culture communication of intangible cultural heritage tourism: A perspective from the ritual view. Journal of Shandong University (Philosophy and Social Sciences), 4(1), 40-46.Zou, W. H. (2014). A study of Stuart Hall’s theory of culture. Beijing: China Social Sciences Press.。

磷酸果糖激酶

磷酸果糖激酶
歐亞書局 CH 15 代謝調節的原則
p.621
代謝肌肉和肝臟的六碳醣激酶同功酶受其產物葡萄糖 6磷酸不同的影響
肌原細胞主要的六碳醣激酶同功酶〔六碳醣激酶 II(
hexokinaseII)〕對於葡萄糖有很高的親和力,它的半飽 和濃度大約 0.1 Mm。
肌肉的六碳醣激酶 I(hexokinase I)與 II 受到它們的
p.624
BOX 15-2 同功酶:可催化相同反應的不同蛋白質 BOX 1-2 FIGURE 1
歐亞書局
CH 15 代謝調節的原則
p.623
六碳醣激酶 IV(葡萄糖激酶)和葡萄糖 6-磷酸酶是經 轉錄調控的
六碳醣激酶 IV 也會在蛋白合成階段受到調控。需要製
造更多能量([ATP] 低、[AMP] 高、劇烈肌肉收縮)或 需要消耗較多葡萄糖(如高血糖)的環境造成六碳醣激 酶 IV 基因轉錄增加。
(ATP)完全飽合,那麼數以百計需要 ATP 的反應其速 率將會減緩(圖 15-5),而細胞或許因許多反應的動力 學效應不能存活了。
歐亞書局
CH 15 代謝調節的原則
p.613
圖 15 – 5
圖15-5 ATP 濃度對典型 ATP-依賴酵素初期速率之影響。由這些實驗 數據得到對 ATP 之 Km 為 5 mM。動物組織中ATP 的度近 5 mM。
CH 15 代謝調節的原則
p.611
基因表現的整體變化可藉由 DNA 微陣列來定量,其
展現在特定細胞類型或器官中的整套 mRNA(轉錄體 ,transcriptome)或是藉著二維凝膠電泳來展現一個 細胞類型或器官的蛋白質全體(蛋白質體,proteome )。
蛋白質體改變的結果常是低分子量代謝物改變的整體

Trust-Based Local and Social Recommendation

Trust-Based Local and Social Recommendation
Trust-Based Local andimon Meyffret
Université de Lyon, CNRS INSA-Lyon, LIRIS, UMR5205, F-69621, France
Lionel Médini
Université de Lyon, CNRS Université Lyon 1, LIRIS, UMR5205, F-69622, France
ABSTRACT
In this article, we propose an evolution of trust-based recommender systems that only relies on local information and can be deployed on top of existing social networks. Our approach takes into account friends’ similarity and confidence on ratings, but limits data exchange to direct friends, in order to prevent ratings from being globally known. Therefore, calculations are limited to locally processed algorithms, privacy concerns can be taken into account and algorithms are suitable for decentralized or peer-to-peer architectures. We have implemented and evaluated our approach against five others, using the Epinions trust network. We show that local information with good default scoring strategies are sufficient to cover more users than classical collaborative filtering and trust-based recommender systems. Regarding accuracy, our approach performs better than most others, specially for cold start users, despite using less information.

转录因子ChREBP对肝脏脂肪从头合成的影响专家讲座

转录因子ChREBP对肝脏脂肪从头合成的影响专家讲座

肉鸭
限饲后强饲玉米,ChREBP表示量增加
转录因子ChREBP对肝脏脂肪从头合成的影响专家讲座
第28页
时间效应:2h内开启,一 浓度效应:从5mM开始,
直增加到12h
在27.5mM到达稳定时
转录因子ChREBP对肝脏脂肪从头合成的影响专家讲座
Li等,
第29页
在葡萄糖调控过程中,是葡萄糖代谢产物而非葡萄
Iyned等,1997 ,Granner,1990 Katsurada,1990
转录因子ChREBP对肝脏脂肪从头合成的影响专家讲座
第17页
转录因以子Ch野RE生BP对型肝脏小脂鼠肪从各头合基成的因影响表专示家讲量座 为1,其相对值
与野生型小鼠 相比: ChREBP敲除 型小鼠LPK、 G6PDH、 ACC、FAS基 因mRNA水平 显著降低
年份
作者
试验对象
结果
Kawaguchi 大鼠及原代 高浓度葡萄糖处理后,ChREBP从

培养肝细胞 细胞质向细胞核转移
Dentin等 唐慧 吕刚
小鼠及原代 高糖处理后,肝细胞核内ChREBP表示 培养肝细胞)量显著升高,活性增加
鹅原代陪肝 发觉在 高葡萄糖浓度处理下:ChREBP
细胞
表示量极显著提升
甲状腺激素、胰岛素对ChREBP表示进行正调控,胰
高血糖素进外,一些药品也对ChREBP表示有影响: 曲格列酮(治疗糖尿病):上调ChREBP表示 阿托伐他汀(治疗高甘油三酯症):下调ChREBP表示
转录因子ChREBP对肝脏脂肪从头合成的影响专家讲座
He等, Rodrigue等, 第26页
Zhang等,
转录因子ChREBP对肝脏脂肪从头合成的影响专家讲座

资料搜集

资料搜集

貳、早期際遇及個人史
事實上,社會學及其他社會科學(social sciences, 譯註:經濟學、社會學、政治學、哲學、歷史學 等的總稱)中許多頂尖的作品,很可能植基於創作 者的早期際遇及/或當前際遇上,這在田野調查 工作傳統及其他研究傳統中皆是如此。
參、駐足在你的立足點上:提 醒之言
我們強烈建議大多數研究者避免如法炮製,尤其以初學 者為然。自傳式資料(autobiographical data)分析研究報告 的處理,即便好到難得一見的地步,也往往被讀者視為 邊緣性自我耽溺(borderline self-indulgence);研究報告的 處理如若只達到勝任愉快之層次的話,泰半會被貼上 「自戀」、「愛現」的標籤,且因為無趣的緣故而被束 之高閣(參見第八章)。
「當藍領階級與白領階級攜手同樂:遊艇 俱樂部案例」(When Blue Collars and White Collars Meet at Play: The Case of the Yacht Club, 1990)
攻讀芝加哥大學研究 所時開計程車維生
「計程車司機與計程車費率:短暫關係的 眾多面向」(The Cabdriver and His Fare: Facets of a Fleeting Relationship, 1959)
第一篇 資料蒐集
© Copyright 版權所有:學富文化事業有限公司。本光碟內容僅提供教師於教學上使用,非經本公司許可,禁止複製 (給學生)。感謝老師的配合。
第一章 從你的立足點起步
© Copyright 版權所有:學富文化事業有限公司。本光碟內容僅提供教師於教學上使用,非經本公司許可,禁止複製 (給學生)。感謝老師的配合。
以即將為人父的身分 探究生育選擇

食品安全风险分析框架

食品安全风险分析框架
➢ JECFA认为一般人类的平均摄入量大致为1 g/kg bw/天,高 消费者大致为4 g/kg bw/天;包括儿童。
18
剂量-反应分析
➢ 非致癌效应的NOEL为2 mg/kg bw/天(90天大鼠试 验)。
➢ 但其主要效应为致癌性。流行病学资料及动物和人的生 物学标记物数据不足以进行评价。
➢ 根据动物致癌性试验结果,用8种数学模型分析,最保 守的乳腺瘤BMDL为0.3 mg/kg bw/天。
食品安全风险分析框架
1
食品安全风险评估机构
➢ WHO:世界卫生组织 ➢ CAC:食品法典委员会 ➢ FDA:食品药品监督管理局 ➢ FAO:联合国粮食及农业组织 ➢ SPS协定:实施卫生与动植物检疫措施协定 ➢ TBT协定:贸易技术壁垒协定 ➢ JECFA:食品添加剂联合委员会 ➢ JMPR:农药残留联合委员会 ➢ NRC:美国国家研究委员会 ➢ CCFA:国际食品法典食品添加剂委员会 ➢ CCFICS:国际食品法典进出口食品检验及认证委员会 ➢ NACMCF:美国微生物基准咨询委员会
21
食物名称 油炸薯类 油条、油饼 方便面 传统中式食品 饼干 蛋糕和面包 咖啡 (速溶) 巧克力 婴儿米粉 婴儿奶粉 婴儿辅食
北京市售食品丙烯酰胺含量
(g/kg bw/天)
样品数 最小值 均值
50
ND 751.7
8
13 79.1
14
ND 24.3
50
ND 111.7
13
ND 367.4
15.0 ND 32.6
(男, mg/kg bw/天 )
暴露量 mg/kg bw/day
10 ADI 5 mg/kg bw/day
9
8
7
6

SSCI收录的经管类期刊

SSCI收录的经管类期刊

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《2024年超常规剂量半枝莲和白花蛇舌草治疗恶性肿瘤安全性的回顾性队列研究》范文

《2024年超常规剂量半枝莲和白花蛇舌草治疗恶性肿瘤安全性的回顾性队列研究》范文

《超常规剂量半枝莲和白花蛇舌草治疗恶性肿瘤安全性的回顾性队列研究》篇一一、引言恶性肿瘤作为全球公共卫生的重要问题,其治疗手段日益受到关注。

传统中草药因其独特的药理作用和较低的副作用,逐渐在肿瘤治疗中占据一席之地。

半枝莲和白花蛇舌草作为常用的抗肿瘤中草药,其超常规剂量的使用在临床实践中逐渐被探索。

然而,关于其超常规剂量使用的安全性问题,尚需进一步的研究和验证。

本研究通过对一组采用超常规剂量半枝莲和白花蛇舌草治疗的恶性肿瘤患者进行回顾性分析,探讨其治疗的安全性。

二、方法本研究采用回顾性队列研究方法,收集某医院肿瘤科采用超常规剂量半枝莲和白花蛇舌草治疗的恶性肿瘤患者的临床资料。

纳入标准为:确诊为恶性肿瘤,接受超常规剂量半枝莲和白花蛇舌草治疗,且具有完整的随访资料。

排除标准为:治疗过程中出现严重并发症或合并其他影响药物安全性的疾病。

三、数据收集与处理收集患者的基本信息(如年龄、性别、肿瘤类型等),治疗过程中的药物剂量、用药时间、不良反应等情况。

采用统计学软件对数据进行处理和分析,比较不同剂量组患者的治疗效果和安全性。

四、结果1. 患者基本情况本研究共纳入120例恶性肿瘤患者,其中男性70例,女性50例。

患者年龄分布广泛,主要肿瘤类型为肺癌、肝癌、乳腺癌等。

2. 药物剂量与治疗效果超常规剂量组患者的药物剂量明显高于常规剂量组。

经过一段时间的治疗,超常规剂量组患者的肿瘤控制率有所提高,但差异无统计学意义。

3. 药物安全性在超常规剂量组中,出现的不良反应主要包括胃肠道反应、肝功能异常等。

其中,轻度不良反应占比较大,经对症治疗后均得到缓解。

严重不良反应发生率较低,无因药物不良反应导致的死亡病例。

4. 剂量与安全性的关系通过对不同剂量组患者的安全性进行分析,发现药物剂量与不良反应的发生率之间存在一定的正相关关系。

但当药物剂量达到一定水平后,继续增加剂量并未显著提高不良反应的发生率。

这说明在保证治疗效果的前提下,适当调整药物剂量可以降低不良反应的发生率。

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14.3 Views of CSR
Two contrasting views used to stimulate debate about merits of CSR • Classical view: management’s only responsibility is to maximise profits; the returns to stockholders

CSR would threaten organisations; foreign competitors may ignore social demands & be more competitive
• Socio-Economic view: organisations have responsibility to the larger society
Cornerstones of Management: Chapter 14
14.9 Reducing Employee Harm to CSR
To ensure employees do not harm the organisation’s CSR stance, the manager needs to:
Cornerstones of Management: Chapter 14
14.1 Introduction
• Last quarter of 20th century, questions asked about organisations having a single economic goal – ‘profit’ • Managers now faced with corporate social responsibility (CSR) – product pricing, philanthropy, employee relations, resource conservation, product quality …. • CSR arises from ethical nature of the organisation, its moral development & ethical codes & strategies that sustain ethical judgement & behaviour
Cornerstones of Management: Chapter 14
14.8 Employees as CSR Citizens
A manager needs to:
• Model positive CSR behaviours • Set clear CSR goals for all employees • Resource CSR training programmes • Promote an underlying ethics programme • Develop quality-of-life outcomes through work-life issuessustains them

survival more important than profit
Cornerstones of Management: Chapter 14
14.4 Four CSR Approaches
Strategy Proactive Commitment Actions
• Set up CSR structures throughout the organisation • Develop protective mechanisms for those active in CSR • Establish CSR reconciliation approaches • Demonstrate CSR procedures in political & business lobbying
Cornerstones of Management: Chapter 14
14.11 Ethics Definitions
• Ethics: a set of beliefs & principles that govern behaviour
• Ethical behaviour: actions which conform to generally accepted social norms • Unethical behaviour: actions which do not conform to generally accepted social norms • Managerial ethics: standards of conduct used by manager in their work
• Build CSR into performance training
• Establish a multi-disciplinary group to undertake social audits • Provide rewards at public ceremonies • Advertise CSR rewards in local media
Cornerstones of Management: Chapter 14
• Public expects social + economic goals
• CSR orgs have more secure profits
• CSR adds to image + customer base • CSR is right for its own sake
• CSR organisations have better work-life balance
Cornerstones of Management: Chapter 14
14.6 Arguments Against CSR
• Organisations most socially responsible when they attend to core economic role • CSR diminishes organisations basic purpose • CSR costs passed on to customers • MNCs too big now & CSR will make them more powerful • Business people poorly equipped to cope with social issues • Business leaders may not be accountable for social goals • Conflict in society about CSR role
Chapter 14
Social Responsibility and Ethics in Management
Cornerstones of Management
Skills in Practice
Chapter Overview
This chapter looks at: • Corporate social responsibility & relevant stakeholders • Values of CSR • Informal social responsibility mechanisms used by organisations • Three major types of managerial ethics • Ethical guidelines for managers • Situational factors affecting ethics • Behaviour in organisations reinforcing ethical behaviour
• CSR limits further govt regulation • CSR balances power & responsibility
• CSR organisations seen as less risky
• CSR resources/professionals can contribute to public projects • CSR organisations act on social problems before damaging production of goods/services
Rule
Operating concept
Obligation to do what is right, just and fair. Avoid harm.
The foundation upon which all the others rest.
Cornerstones of Management: Chapter 14
Cornerstones of Management: Chapter 14
14.2 Grid of CSR
1 Voluntary responsibility Be a good corporate citizen Contribute resources to the community, improve the quality of life. 2 Ethical responsibility Be ethical 3 Legal responsibility Obey the law Law is society’s coding of right and wrong. Play by the rules of the game. 4 Economic responsibility Be profitable Type
Cornerstones of Management: Chapter 14
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