专业英语课文翻译

School of chemical engineering and pharmaceutical

test tubes 试管test tube holder试管夹

test tube brush 试管刷 test tube rack 试管架

beaker烧杯 stirring搅拌棒 thermometer 温度计boiling flask长颈烧瓶Florence flask平底烧瓶

flask,round bottom,two-neck boiling flask,three-neck

conical flask锥形瓶 wide-mouth bottle广口瓶

graduated cylinder量筒 gas measuring tube气体检测管

volumetric flask容量瓶 transfer pipette移液管

Geiser burette(stopcock)酸式滴定管funnel漏斗

Mohr burette(with pinchcock)碱式滴定管watch glass表面皿 evaporating dish 蒸发皿 ground joint磨口连接 Petri dish有盖培养皿

desiccators干燥皿

long-stem funnel长颈漏斗 filter funnel 过滤漏斗

Büchner funnel瓷漏斗separatory funnel分液漏斗

Hirsh funnel赫尔什漏斗 filter flask 吸滤瓶

Thiele melting point tube蒂勒熔点管plastic squeeze bottle塑料洗瓶 medicine dropper药用滴管

rubber pipette bulb 吸球 microspatula 微型压舌板

pipet吸量管 mortar and pestle 研体及研钵

filter paper滤纸 Bunsen burner 煤气灯

burette stand滴定管架 support ring 支撑环

ring stand环架 distilling head 蒸馏头

side-arm distillation flask侧臂蒸馏烧瓶

air condenser空气冷凝器 centrifuge tube离心管

fractionating column精(分)馏管

Graham condenser蛇形冷凝器

crucible坩埚crucible tongs坩埚钳beaker tong烧杯钳

economy extension clamp经济扩展夹 extension clamp牵引夹

utility clamp铁试管夹 hose clamp软管夹burette clamp

pinchcock;pinch clamp弹簧夹 screw clamp 螺丝钳

ring clamp 环形夹goggles护目镜stopcock活塞wire gauze铁丝网analytical balance分析天平

分析化学

absolute error绝对误差 accuracy准确度assay化验

analyte(被)分析物calibration校准constituent成分

coefficient of variation变异系数confidence level置信水平

detection limit检出限 determination测定estimation 估算

equivalent point等当点 gross error总误差impurity杂质indicator指示剂interference干扰internal standard内标level of significance显着性水平 limit of quantitation定量限masking掩蔽matrix基体 precision精确度

primary standard原始标准物 purity 纯度

qualitative analysis定性分析

quantitative analysis定量分析

random error偶然误差 reagent试剂relative error相对误差 robustness耐用性sample样品

relative standard deviation相对标准偏差selectivity选择性

sensitivity灵敏度 specificity专属性titration滴定

significant figure有效数字 solubility product溶度积

standard addition标准加入法standard deviation标准偏差

standardization标定法 stoichiometric point化学计量点

systematic error系统误差

有机化学

acid anhydride 酸酐acyl halide 酰卤alcohol 醇aldehyde 醛aliphatic 脂肪族的alkene 烯烃alkyne炔allyl烯丙基amide氨基化合物amino acid 氨基酸aromatic compound 芳香烃化合物 amine胺butyl 丁基

aromatic ring芳环,苯环 branched-chain支链 chain链

carbonyl羰基carboxyl羧基chelate螯合

chiral center手性中心conformers构象copolymer共聚物derivative 衍生物dextrorotatary右旋性的diazotization重氮化作用 dichloromethane二氯甲烷ester 酯 ethyl乙基 fatty acid脂肪酸

functional group 官能团general formula 通式 glycerol 甘油，丙三醇 heptyl 庚基heterocyclie 杂环的hexyl 己基 homolog 同系物hydrocarbon 烃,碳氢化合物hydrophilic 亲水的hydrophobic 疏水的hydroxide 烃基ketone 酮levorotatory左旋性的 methyl 甲基

molecular formula分子式monomer单体octyl辛基open chain开链optical

activity旋光性（度）organic 有机的organic chemistry 有机化学

organic compounds有机化合物 pentyl 戊基 phenol苯酚phenyl苯基polymer 聚合物，聚合体 propyl丙基ring-shaped环状结构zwitterion兼性离子

saturated compound饱和化合物side chain 侧链straight chain 直链tautomer互变（异构）体

structural formula结构式triglyceride甘油三酸脂

unsaturated compound不饱和化合物

物理化学

activation energy活化能 adiabat绝热线amplitude振幅

collision theory碰撞理论empirical temperature假定温度

enthalpy焓 enthalpy of combustion 燃烧焓

enthalpy of fusion熔化热 enthalpy of hydration水合热 enthalpy of reaction反应热

enthalpy o f sublimation升华热

enthalpy of vaporization汽化热entropy熵

first law热力学第一定律 first order reaction一级反应

free energy自由能 Hess’s law盖斯定律

Gibbs free energy offormation吉布斯生成能

heat capacity热容 internal energy内能isobar等压线 isochore等容线isotherm 等温线 kinetic energy动能 latent heat 潜能Planck’s constant普朗克常数potential energy势能quantum量子quantum mechanics量子力学rate law速率定律 specific heat比热 spontaneous自发的

standard enthalpy change标准焓变

standard entropy of reaction标准反应熵standard molar entropy标准摩尔熵standard pressure标压

state function状态函数thermal energy热能

thermochemical equation热化学方程式thermodynamic equilibrium热力学平衡uncertainty principle测不准定理

zero order reaction零级反应zero point energy零点能

课文词汇

实验安全及记录：

eye wash眼药水 first-aid kit急救箱gas line输气管

safety shower紧急冲淋房 water faucet 水龙头

flow chart流程图 loose leaf活页

单元操作分类：heat transfer传热Liquid-liquid extraction液液萃取

liquid-solid leaching过滤vapor pressure蒸气压

membrane separation薄膜分离

空气污染：

carbon dioxide 二氧化碳carbon monoxide 一氧化碳

particulate matter颗粒物质photochemical smog光化烟雾

primary pollutants一次污染物secondary pollutants二次污染物stratospheric ozone depletion平流层臭氧消耗

sulfur dioxide二氧化硫volcanic eruption火山爆发

食品化学：

amino acid氨基酸,胺 amino group氨基empirical formula实验式,经验式fatty acid脂肪酸

peptide bonds肽键 polyphenol oxidase 多酚氧化酶

salivary amylase唾液淀粉酶 steroid hormone甾类激素

table sugar蔗糖 triacylglycerol三酰甘油,甘油三酯

食品添加剂：

acesulfame-K乙酰磺胺酸钾,一种甜味剂adrenal gland肾上腺ionizing radiation致电离辐射

food additives食品添加剂

monosodium glutamate味精,谷氨酸一钠（味精的化学成分） natural flavors天然食用香料,天然食用调料

nutrasweet天冬甜素potassium bromide 溴化钾propyl gallate没食子酸丙酯sodium chloride氯化钠sodium nitraten硝酸钠 sodium nitrite亚硝酸钠trans fats 反式脂肪

genetic food转基因食品food poisoning 食物中毒

hazard analysis and critical control points (HACCP)

危害分析关键控制点技术

maternal and child health care妇幼保健护理

national patriotic health campaign committee(NPHCC) 全国爱国卫生运动委员会 rural health农村卫生管理

the state food and drug administration (SFDA)

国家食品药品监督管理局

光谱：Astronomical Spectroscopy天文光谱学

Laser Spectroscopy激光光谱学Mass Spectrometry质谱

Atomic Absorption Spectroscopy原子吸收光谱

Attenuated Total Reflectance Spectroscopy

衰减全反射光谱

Electron Paramagnetic Spectroscopy电子顺磁谱

Electron Spectroscopy电子光谱

Infrared Spectroscopy红外光谱

Fourier Transform Spectrosopy傅里叶变换光谱

Gamma-ray Spectroscopy伽玛射线光谱Multiplex or Frequency-Modulated Spectroscopy

复用或频率调制光谱X-ray SpectroscopyX射线光谱

色谱：Gas Chromatography气相色谱

High Performance Liquid Chromatography 高效液相色谱Thin-Layer Chromatography 薄层色谱

magnesium silicate gel硅酸镁凝胶retention time保留时间mobile phase流动相stationary phase固定相

反应类型：

agitated tank搅拌槽 catalytic reactor 催化反应器

batch stirred tank reactor间歇搅拌反应釜

continuous stirred tank 连续搅拌釜exothermic reactions放热反应 pilot plant试验工厂

fluidized bed Reactor流动床反应釜multiphase chemical reactions 多相化学反应

packed bed reactor填充床反应器

redox reaction氧化还原反应reductant-oxidant氧化还原剂 acid base reaction酸碱反应 additionreaction加成反应chemical equation化学方程式 valence electron价电子

combination reaction化合反应hybrid orbital 杂化轨道

decomposition reaction分解反应substitution reaction取代(置换)反应

Lesson5 Classification of Unit Operations单元操作

Fluid flow流体流动

它涉及的原理是确定任一流体从一个点到另一个点的流动和输送。

Heat transfer传热

这个单元操作涉及的原理是控制不同位置处热量和能量的积累和转移。

Evaporation蒸发

它涉及易挥发溶剂的蒸发，这些溶剂来自不易挥发的溶质，诸如盐或溶液中任意其他物质。

Drying干燥

这个操作是将易挥发的液体（通常为水）从固体物质中移除。

Distillation蒸馏

蒸馏是基于不同液体的蒸汽压不同，通过加热煮沸将一个液体混合物分离。Absorption吸收

吸收是将一种化合物从气体流中转移到液体中。

Membrane separation薄膜分离

这个过程包含从液体或气体的溶质通过一个暂时性的薄膜扩散到另一液体中。

Liquid-liquid extraction液液萃取

在这个操作中，溶液中的溶质被转移到与之接触的，与溶液相对不溶的里一种液体溶剂中。

Liquid-solid leaching过滤

过滤用于处理液体中的细微待分离固体，并可得到包含在固体中的溶质移出。

Crystallization结晶

该操作可实现溶质的回收，例如溶液中的盐可通过液体中的溶质沉淀获得。

Mechanical physical separation机械物理分离

机械物理分离是应用机械手段来实现固体、液体或气体的分离。例如过滤、沉淀和缩小体积，机械分离常被归入分离的单元操作。

Lesson6 Fractional Distillation分馏

分馏是根据混合物里面化合物的沸点，将其加热到足够高的温度从而达到分离。

(1)Apparatus实验装置：

圆底烧瓶

锥形瓶

李比希冷凝器

抗爆沸原板颗粒

温度计

橡胶塞(除非快速适应使用)

(2)Method试验方法：

例如，乙醇和水的混合物蒸馏。酒精在78.5℃时沸腾，而水的沸点是100℃。因此，通过轻轻加热混合物，酒精会首先沸腾。一些混合物形成共沸物，在较低的温度下的那个混合物会比另一成分的化合物先沸腾。在乙醇的例子中，由95%乙醇和5%的水组成的混合物煮沸到78.2℃。所以不能完全将乙醇蒸馏提纯。

该实验装置如图所示。将混合物装入圆底烧瓶并放入一些防爆沸小粒，并且将分馏管安装在顶部。当混合物沸腾时，蒸汽上升到分馏管。蒸汽在冷凝管中凝结，向下流动回流冷却蒸馏物聚成液体。只有大部分挥发性的蒸汽处于气体状态一直到达顶部。在分馏管顶部的蒸汽几乎是纯乙醇。然后传递到冷凝管，使它冷却下来，直到它液化。这个过程持续到将所有的乙醇从混合物中蒸发出来。这一点能够通过温度计中温度的急剧上升而识别出从乙醇的沸点到水的沸点。(3)Industrial uses of F…工业分馏---炼油厂

最重要的工业应用分馏是原油的分馏。除了规模以外，这个过程的原则类似于以上的实验室方法，连续供料和操作。而事实上，原油由许多不同的化合物混合在一起。分馏塔的柱子上有一出口能够允许不同温度段的不同馏分有规律的溢流出来，具有高度挥发性的气体将会从最顶端的阀门逸出，而挥发性较小的筑路焦油则从底部出来。

Lesson7 Crystallization结晶化

结晶是一种化学家利用它净化固体化合物的技术。这是一种每个化学家在实验室必须熟练掌握的基本程序。结晶是以溶解度原则为基础:化合物(溶质)更倾向于溶于热的液体(溶剂)而非冷的液体。如果允许饱和热溶液冷却，溶质不再溶于溶剂和形成纯化合物晶体。杂质从生长的晶体中被排除和纯固态晶体可通过过滤从溶解的杂质中被分离。

(1)加热溶剂至沸腾，把固体放入一个锥形瓶重结晶。

(2)向含有固体的锥形瓶中倒入少量的热溶剂。

(3)强烈振荡锥形瓶使固体溶解。

(4)将锥形瓶放在蒸气浴上，以保持溶液高温。

(5)如果仍有不溶解固体，可以加入少量溶剂和强

烈振荡。

(6)当所有固体都溶解了，把锥形瓶放在工作台上。不要动它！

(7)过一会儿后，晶体出现在锥形瓶中。

(8)你现在可以把锥形瓶放入冰浴中来完成结晶过程。

Lesson 11 Heat Transfer传热

1 Basics of Heat Transfer基本传热

In the simplest of terms, the discipline of heat transfer is concerned with only two things: temperature, and the flow of heat. Temperature represents the amount of thermal energy available, whereas heat flow represents the movement of thermal energy from place to place.

在最简单的术语，传热学科关注的只有两件事：温度，和热流量。温度是热能源的数量，而热流代表的热能从一个地方移动到的地方。

On a microscopic scale, thermal energy is related to the kinetic energy of molecules. The greater a material's temperature, the greater the thermal agitation of its constituent molecules (manifested both in linear motion and vibrational modes). It is natural for regions containing greater molecular kinetic energy to pass this energy to regions with less kinetic energy.

在微观尺度，热能是分子的动能相关。更大的物质的温度，其组成分子的热运动更大的（表现在直线运动模式）和振动。含有大分子的动能来传递能量到较小的动能的地区是自然的。 Several material properties serve to modulate the heat transferred between two regions at differing temperatures. Examples include thermal conductivities, specific heats, material densities, fluid velocities, fluid viscosities, surface emissivities, and more. Taken together, these properties serve to make the solution of many heat transfer problems an involved process. 几种材料的性能起到调节转移之间的两个区域在不同温度下的热。例子包括的热传导率，比热，密度，流体速度，流体粘度，表面的发射率，和更多。总之，这些特性使许多传热问题，一个复杂的过程，解决方案。

2. Heat Transfer Mechanisms传热机制

Heat transfer mechanisms can be grouped into 3 broad categories:

传热机制可以分为3大类：

Conduction: Regions with greater

molecular kinetic energy will pass their thermal energy to regions with less molecular energy through direct molecular collisions, a process known as conduction. In metals, a significant portion of the transported thermal energy is also carried by conduction-band electrons.

传导：更大的分子动能的地区将通过他们的热能通过分子的直接碰撞不分子的能量区域，这个过程被称为传导。在金属的热能源，运输的一个重要部分，也是由导带电子进行。

Convection: When heat conducts into a static fluid it leads to a local volumetric expansion. As a result of gravity-induced pressure gradients, the expanded fluid parcel becomes buoyant and displaces, thereby transporting heat by fluid motion (i.e. convection) in addition to conduction. Such heat-induced fluid motion in initially static fluids is known as free convection.

对流：当热传递到一个静态流体导致局部体积膨胀。作为一个结果，诱导的压力梯度，重力，浮力和流体包裹成为扩大移除，从而输送热流体运动（即对流）除了传导。这样的热诱导的流体运动的最初的静态液体被称为自由对流。Radiation: For cases where the fluid is already in motion, heat conducted into the fluid will be transported away chiefly by fluid convection. These cases, known as forced convection, require a pressure gradient to drive the fluid motion, as opposed to a gravity gradient to induce motion through buoyancy.

辐射：对于流体已经在运动，进行了流体热将被运走，主要是由流体对流。这些情况下，被称为强制对流，需要的压力梯度驱动的流体的运动，而不是一个重力梯度诱导运动通过浮力.

Lesson 14 Air Pollution大气污染

Air pollution is the human introduction into the atmosphere of chemicals, particulate matter, or biological materials that cause harm or discomfort to humans or other living organisms, or damages the natural environment. Air pollution causes deaths and respiratory disease. Air pollution is often identified with major stationary sources, but the greatest source of emissions is mobile sources, mainly automobiles. Gases such as carbon dioxide, which contribute to global warming, have recently gained recognition as pollutants by climate scientists, while they also recognize that carbon dioxide is essential

for plant life through photosynthesis.

空气污染颗粒物的人引入化学，大气，或生物材料，造成伤害或不适的人类或其他生物，或破坏自然环境。空气污染造成的死亡和呼吸系统疾病。空气污染往往是确定的主要固定污染源，但排放的最大来源是移动的来源，主要是汽车。二氧化碳之类的气体，是导致全球变暖，最近的气候科学家的污染物得到了认可，而他们也承认，二氧化碳是通过光合作用的植物生命所必需的。

The atmosphere is a complex, dynamic natural gaseous system that is essential to support life on planet Earth. Stratospheric ozone depletion due to air pollution has long been recognized as a threat to human health as well as to the Earth's ecosystems.

大气是一个复杂的，动态的天然气系统，来支持地球上的生命本质。平流层臭氧耗竭因空气污染一直是威胁人类健康和地球的生态系统。

Pollutants污染物

An air pollutant is known as a substance in the air that can cause harm to humans and the environment. Pollutants can be in the form of solid particles, liquid droplets, or gases. In addition, they may be natural or man-made.

一种空气污染物被称为空气中的物质，可以对人体和环境造成的危害。污染物可在固体颗粒，形成液滴，或气体。此外，他们可能是天然的或人造的。

Pollutants can be classified as either primary or secondary. Usually, primary pollutants are substances directly emitted from a process, such as ash from a volcanic eruption, the carbon monoxide gas from a motor vehicle exhaust or sulfur dioxide released from factories.

污染物可以被归类为主要或次要。通常，一个过程的主要污染物是从直接排放的物质，如火山喷发的火山灰，一氧化碳气体来自汽车废气、二氧化硫释放从工厂。

Secondary pollutants are not emitted directly. Rather, they form in the air when primary pollutants react or interact. An important example of a secondary pollutant is ground level ozone - one of the many secondary pollutants that make up photochemical smog.

二次污染物不能直接排放。相反，它们形成在空气中主要污染物反应或相互作用。一种二次污染的一个重要的例子是地面臭氧是光化学烟雾，使许多二次污染

Note that some pollutants may be both primary and secondary: that is, they are both emitted directly and formed from other primary pollutants.

请注意，有些污染物可能是原发性和继发性：即，他们都是直接排放和其他主要污染物的形成。

Major primary pollutants produced by human activity include:

主要由人类活动产生的主要污染物包括：

Sulfur oxides (SOx) especially sulfur dioxide a chemical compound with the formula SO2. SO2 is produced by volcanoes and in various industrial processes. Since coal and petroleum often contain sulfur compounds, their combustion generates sulfur dioxide. Further oxidation of SO2, usually in the presence of a catalyst such as NO2, forms H2SO4, and thus acid rain.[2] This is one of the causes for concern over the environmental impact of the use of these fuels as power sources. 硫氧化物（SOx）尤其是二氧化硫和二氧化硫的化学化合物公式。二氧化硫是由火山和各种工业过程产生的。从煤和石油中常含有硫化合物，其燃烧产生的二氧化硫。SO2的进一步氧化，通常在催化剂的存在下，如NO2，形成硫酸，从而酸雨。这是[ 2 ]在使用这些燃料作为动力来源的环境影响问题的原因之一。

Nitrogen oxides (NOx) especially nitrogen dioxide are emitted from high temperature combustion. Can be seen as the brown haze dome above or plume downwind of cities.Nitrogen dioxide is the chemical compound with the formula NO2. It is one of the several nitrogen oxides. This reddish-brown toxic gas has a characteristic sharp, biting odor. NO2 is one of the most prominent air pollutants.

氮氧化物（NOx）特别是二氧化氮是高温燃烧排放。可以被看作是棕色的圆顶或羽顺风的城市。二氧化氮NO2与公式的化合物。这是一个几个氮氧化物。这红棕色的有毒气体，有一个特点鲜明，咬的气味。二是其中最为突出的空气污染物。

Carbon monoxide is colourless, odourless, non-irritating but very poisonous gas. It is a product by incomplete combustion of fuel such as natural gas, coal or wood. Vehicular exhaust is a major source of carbon monoxide.

一氧化碳是无色，无味，无刺激性的但非常有毒气体。它是由燃料如天然气不完全燃烧的产物，煤和木材。汽车尾气是一氧化碳的主要来源。

Carbon dioxide (CO2), a greenhouse gas emitted from combustion.

二氧化碳（CO2），一种温室气体排放燃烧。

Volatile organic compounds VOCs are an important outdoor air pollutant. In this field they are often divided into the separate categories of methane ((CH4) and non-methane (NMVOCs). Methane is an extremely efficient greenhouse gas which contributes to enhanced global warming. Other hydrocarbon VOCs are also significant greenhouse gases via their role in creating ozone and in prolonging the life of methane

in the atmosphere, although the effect varies depending on local air quality. Within the NMVOCs, the aromatic compounds benzene, toluene and xylene are suspected carcinogens and may lead to leukemia through prolonged exposure. 1,3-butadiene is another dangerous compound which is often associated with industrial uses.

挥发性有机化合物是一种重要的室外空气污染物。在这场他们往往分为不同的类别（甲烷（CH4）和非甲烷（NMVOCs）。甲烷是一种非常有效的温室气体，有助于增强全球变暖。其他烃类VOCs 是重要的温室气体，通过产生臭氧和延长了甲烷在大气中的寿命的作用，虽然效果取决于当地的空气质量。在NMVOCs芳香族化合物，苯，甲苯和二甲苯是可疑致癌物质，可以通过延长曝光导致白血病。丁二烯是另一个危险的化合物，通常是用工业用途有关的。

Particulate matter Particulates, alternatively referred to as particulate matter (PM) or fine particles, are tiny particles of solid or liquid suspended in a gas. In contrast, aerosol refers to particles and the gas together. Sources of particulate matter can be man made or natural. Some particulates occur naturally, originating from volcanoes, dust storms, forest and grassland fires, living vegetation, and sea spray. Human activities, such as the burning of fossil fuels in vehicles, power plants and various industrial processes also generate significant amounts of aerosols. Averaged over the globe, anthropogenic aerosols—those made by human activities—currently account for about 10 percent of the total amount of aerosols in our atmosphere. Increased levels of fine particles in the air are linked to health hazards such as heart disease, altered lung function and lung cancer.

颗粒物质的微粒，或者称为颗粒物(PM)或细颗粒，是固体或液体悬浮在空气中的微小颗粒。相反，气溶胶是指颗粒与气体一起。大气颗粒物源可以是人造或天然。有些颗粒物是自然发生的，从火山，沙尘暴，森林和草原火灾，有生命的植物，和浪花。人类活动，如燃烧化石燃料的车辆，电厂和各种工业过程中也产生了大量的气溶胶。全球平均的，人为气溶胶由人类活动使目前约占大气中的气溶胶总金额的百分之10。空气中的微粒的水平升高与健康的危害，如心脏病，肺功能的改变与肺癌。

oxic metals, such as lead, cadmium and copper.

有毒金属，如铅，镉和铜。

Chlorofluorocarbons (CFCs), harmful to the ozone layer emitted from products currently banned from use. 氯氟烃（CFCs），从目前禁止使用的产品排放破坏臭氧层。

NH3. It is normally encountered as a gas with a characteristic pungent odor. Ammonia contributes significantly to the nutritional needs of terrestrial organisms by serving as a precursor to foodstuffs and fertilizers. Ammonia, either directly or indirectly, is also a building block for the synthesis of many pharmaceuticals. Although in wide use, ammonia is both caustic and hazardous.

氨（NH3）从农业过程中排放。氨是一种具有氨化合物公式。它通常是作为一种气体具有刺鼻的气味遇到。氨对陆地生物的营养需求明显作为食品和肥料的前兆。氨，直接或间接的影响，也对许多药物的合成砌块。尽管广泛使用，是碱和有害的氨。

Odors, such as from garbage, sewage, and industrial processes

气味，如垃圾，污水，工业过程

Radioactive pollutants produced by nuclear explosions, war explosives, and natural processes such as the radioactive decay of radon.

放射性污染物的核爆炸产生的爆炸，战争，和自然过程，如氡的放射性衰变。

Secondary pollutants include:

二次污染物包括：Particulate matter formed from gaseous primary pollutants and compounds in photochemical smog .Smog is a kind of air pollution; the word ―smog‖ is a portmanteau of smoke and fog. Classic smog results from large amounts of coal burning in an area caused by a mixture of smoke and sulfur dioxide. Modern smog does not usually come from coal but from vehicular and industrial emissions that are acted on in the atmosphere by sunlight to form secondary pollutants that also combine with the primary emissions to form photochemical smog.

颗粒物质从气态污染物和光化学烟雾形成的化合物。烟雾是一种空气污染；―烟雾‖是一个合成烟与雾。结果经典的烟雾从大量的煤炭燃烧面积混合引起的烟尘和二氧化硫。现代的烟雾不经常来自于煤，但从汽车和工业排放物，作用在大气中经阳光照射产生的二次污染物，也与主要排放物结合形成光化学烟雾。

Ground level ozone (O3) formed from NOx and VOCs. Ozone (O3) is a key constituent of the troposphere (it is also an important constituent of certain regions of the stratosphere commonly known as the Ozone layer). Photochemical and chemical reactions involving it drive many of the chemical processes that occur in the atmosphere by day and by night. At abnormally high concentrations brought about by human

activities (largely the combustion of fossil fuel), it is a pollutant, and a constituent of smog.

地面臭氧（O3）的NOx和VOCs形成。臭氧（O3）是对流层的关键组成部分（也是俗称的平流层臭氧层的某些地区一个重要的组成部分）。光化学和化学反应驱动多发生在白天和夜间的大气化学过程。在由人类活动带来的异常高浓度（主要是化石燃料的燃烧），它是一种污染物，和烟雾的一个组成部分。

Peroxyacetyl nitrate (PAN) similarly formed from NOx and VOCs.

过氧硝酸（PAN）的NOx和VOCs同样构成。

Minor air pollutants include:

轻微的空气污染物包括：

A large number of minor hazardous air pollutants. Some of these are regulated in USA under the Clean Air Act and in Europe under the Air Framework Directive.

大量小的有害空气污染物。这些规定在美国清洁空气法案下，欧洲的空气框架指令。

A variety of persistent organic pollutants, which can attach to particulate matter.

各种持久性有机污染物，它可以附着在颗粒物。

Persistent organic pollutants (POPs) are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes. Because of this, they have been observed to persist in the environment, to be capable of long-range transport, bioaccumulate in human and animal tissue, biomagnify in food chains, and to have potential significant impacts on human health and the environment.

持久性有机污染物（POPs）是耐环境退化是通过化学，生物有机化合物，和光解过程。正因为如此，他们已观察到持续存在于环境中，能远距离运输，生物蓄积在人体和动物的组织，在食物链的生物放大作用，并具有潜在的显着的对人类健康和环境的影响

Lesson 21 Medical Chemistry

Chemistry has long been an integral part of the pharmaceutical industry and its importance should not diminish. Many currently marketed drugs such as the antineoplastic agent, paclitaxel, and the antibiotic, vancomycin, are natural products. The extracts of plants and marine organisms and the products of soil bacteria fermentation will continue to be investigated as potential sources of powerful new drug substances. Chemists are certainly involved in this arena of drug discovery as they conduct

the painstaking isolation, purification, and structural characterization of pharmacologically active components which most often are present in minute amounts in the natural source and which have extremely complex chemical structures. The enormous advances in molecular biology have resulted in the successful development of bio-engineered therapeutic agents, for example, human insulin, Herceptin (Genentech drug for breast cancer), and Enbrel (Immunex drug for rheumatoid arthritis). It is anticipated that many other biomolecules may be forthcoming for the treatment of human disease.

化学一直是制药行业的一个组成部分，其重要性不应该减少。许多已上市的药物如抗肿瘤药物，紫杉醇，和抗生素，万古霉素，是天然产品。植物和海洋生物和土壤细菌的发酵产品提取将继续研究的强大的新的药物的潜在来源。化学家确实参与了这一领域的药物发现他们进行艰苦的分离，纯化和药理活性成分，其中最常见的是存在于微量的天然来源，具有极其复杂的化学结构表征。在分子生物学的巨大进步已导致在生物工程药物的研制成功，例如，人胰岛素，赫赛汀（Genentech的药物对乳腺癌），和Enbrel （内克斯风湿性关节炎药物）。据预计，许多其他生物分子可能是即将到来的人类疾病的治疗。However the great majority of existing drugs are small organic molecules (MW-200-600) that have been synthesized by medicinal chemists. There is no reason to doubt that most drugs of the future will also fall in this category. It is thus important to define what is meant by ―medicinal chemist‖ and what role is played by the practitioners of this sub-discipline in the pharmaceutical industry. A traditional and perhaps somewhat narrow definition of medicinal chemist is that of a researcher engaged in the design and synthesis of bioactive molecules. As part of their academic training，many medicinal chemists carried out doctoral and postdoctoral work that involved the total synthesis of natural products andor the development of synthetic methodology. They are hired by pharmaceutical companies because of the skills they have gained in planning and conducting the synthesis of organic compounds. While such skills can remain important throughout chemists’careers, they alone are insufficient for the challenging task of drug discovery in which, unlike the academic environment, synthetic chemistry is just a means to an end rather than an end in itself. Thus, the enterprising young chemical researcher who enters the industry must be able and willing to undergo an evolution from that of pure synthetic chemist who knows how

to make compounds to that of medicinal chemist who also has an insight into what to make and why.

然而，现有的药物，绝大多数是有机小分子（mw-200-600）已被药物化学家合成了。没有理由怀疑大多数药物的未来也属于这一类。因此，定义什么是―药用化学家‖和什么角色是由这一分支学科的从业者在制药工业中起着重要的。传统甚至有些狭隘的药物化学家是一个研究员，从事与生物活性分子的设计合成。作为他们的学术训练的一部分，许多药物化学家进行博士和博士后工作涉及天然产物的全合成及合成方法的发展。他们受雇于制药公司因为他们在策划和进行合成有机化合物获得的技能。虽然这样的技能可以在药店的事业仍然是重要的，他们还不足以在药物发现的具有挑战性的任务，不同的学术环境，合成化学只是达到目的的一种手段，而不是目的本身。因此，有进取心的年轻化学研究员进入行业必须能够和愿意接受一个从纯的合成化学家谁知道如何使化合物的药物化学家谁也洞察到做和为什么。 Such insight is gained by acquiring an expanded knowledge base. It is important for the medicinal chemist to know what structural components act as pharmacophores in existing drugs. Pharmacophores, which can be of varying complexity, comprise the essential structural elements of a drug molecule that enable it to interact on the molecular level with a biological macromolecule such as a receptor or enzyme and thus impart a pharmacological effect. The medicinal chemist must become skilled at analyzing the structure activity relationships (SAR) that pertain to the series of compounds on which he is working. That is, how does the activity in a biological test of analogs within the series change depending on the introduction of substituents of various size, polarity, and lipophilicity at various domains of the parent drug molecule? Elucidation of the SAR within a series of active compounds is the key to optimizing the potency and other desirable biological properties in order to identify a new chemical entity (NCE) as a bona fide drug candidate. Quantitative structure activity relationships (QSAR) are often employed in this effort; analyses employing linear free energy relationships, linear regression, and other techniques can be utilized to correlate biological activity with the electronic, steric, polarizability, and other physicallchemical parameters of the substituent groups on members of a series of structurally related compounds.

这种见解是通过收购扩大知识库了。要知道结构构件作为现有药物的药效的药物化学家很重要。药效基团，可以不同的复杂性，包含一种药物分子，使其在与生物大分子如受体或酶分子水平的相互作用，从而产生药

理效应的结构要素。药用化学家必须成为熟练的分析结构-活性关系（SAR）属于该系列化合物对他工作的。那就是，如何在生物试验活动的类似物在一系列的变化取决于各种大小，取代基的引入极性，和亲脂性的母体药物分子在不同领域？在一系列的活性化合物的SAR鉴定是优化以及其他优良的生物学特性的效力来确定一个新的化学实体的关键（NCE）作为一个善意的候选药物。定量结构活性关系（QSAR）经常被用在这方面的努力；分析采用线性自由能关系，线性回归，和其他技术可用于生物活性与电子，空间，极化和关联，对一系列的结构上相关的化合物的取代基参数等physicallchemical成员。

The synthesis and isolation of pure enantiomers has become increasingly important. In the past chiral drugs were most often marketed as racemic mixtures since it was not deemed cost-effective to provide them in enantiomercially pure form. However, in many cases one or the other enantiomers of an optically active drug may have a significantly greater level of the desired biological activity and/or less side effect liability than its antipode. Regulatory agencies such as the FDA now routinely require that each enantiomer of a chiral drug be isolated and evaluated in tests of efficacy, side effects, and toxicity. If one of the enantiomers is shown to be clearly superior then it is likely that it is the form that will be developed as the drug candidate. Thus enantioselective chemical reactions which can afford a high enantiomeric excess(ee) of one or the other of a pair of enantiomers are valuable components of the medicina l chemist’s synthetic tools. Enzyme chemistry plays a prominent role in drug R&D since isolated enzymes or microorganisms can often achieve an enantiospecific chemical transformation much more efficiently and economically than conventional synthetic methods. Many ―big pharma‖companies now have dedicated groups that exclusively study enzymatic reactions.

与纯对映异构体的分离已成为越来越重要的合成。在过去的手性药物是最经常被作为外消旋混合物，因为它被认为是不符合成本效益enantiomercially纯粹的形式提供给他们。然而，在许多情况下，一个或一个光学活性的药物可能比其他的对映体的对映体的一个显着更大的所需的生物活性和/或副作用少负债水平。管理机构如美国食品和药物管理局现在经常要求每个对映异构体的手性药物分离和测试评价疗效，副作用，毒性。如果其中的一个对映体被证明是明显优于那么很可能它是形式，将发展作为候选药物。因此，对映选择性化学反应可负担得起的高对映体过量（ee）的一个或一对对映体的其他的药物化学家的合成工具价值的成分。酶化学在药物研发从分离的酶或微生物往往可以实

现手性化学转化更有效和经济上比传统的合成方法发挥了突出的作用。许多―大制药公司现在有专门小组，专门研究酶促反应。

Lesson 23 Food Nutrition

Food is any substance, usually composed primarily of carbohydrates, fats, water and/or proteins, that can be eaten or drunk by an animal or human for nutrition or pleasure.

食物是什么物质，通常由主要是碳水化合物，脂肪，水分和/或蛋白质，能吃或一个动物或人体对营养和乐趣醉。

here are seven major classes of nutrients: carbohydrates , fats , fiber , minerals, proteins, vitamins, and water. These nutrient classes can be generally grouped into the categories of macronutrients (needed in relatively large amounts), and micronutrients (needed in smaller quantities). The macronutrients are carbohydrates, fats, fiber, proteins and water. The micronutrients are minerals and vitamins.

有七大类：营养，碳水化合物，脂肪，纤维，矿物质，蛋白质，维生素，和水。这些营养类一般可分为宏量营养素的种类（金额比较大的需要），以及微量元素（需要在较小的数量）。宏量营养素是碳水化合物，脂肪，纤维，蛋白质和水。微量营养素是维生素与矿物质。The macronutrients (excluding fiber and water) provide energy, which is measured in Joules or kilocalories (often called ―Calories‖and written with a capital C to distinguish from gram calories). Carbohydrates and proteins provide 17 kJ (4 kcal) of energy per gram, while fats provide 37 kJ (9 kcal) per gram. Vitamins, minerals, fiber, and water do not provide energy, but are necessary for other reasons.

大量营养素（不含纤维和水）提供能量，这是焦耳或热量测量（通常称为―卡路里‖和大写C区分克卡路里）。碳水化合物和蛋白质为17 kJ（4大卡）的每克脂肪提供能量，而37 kJ（9大卡）每克。维生素，矿物质，纤维，和水不提供能量，但所需的其他原因。

Molecules of carbohydrates and fats consist of carbon, hydrogen, and oxygen atoms. Carbohydrates may be simple monomers (glucose, fructose, galactose), or large polymers polysaccharides (starch). Fats are triglycerides, made of various fatty acid monomers bound to glycerol. Some fatty acids are essential, but not all. Protein molecules contain nitrogen atoms in addition to the elements of carbohydrates and fats. The nitrogen-containing monomers of protein, called amino acids, fulfill many roles other than energy metabolism, and when