英文论文Cover letter模板

英文论文Cover letter模板
英文论文Cover letter模板

英文论文Cover letter模板

英文论文投稿信Cover letter模板

Case 1

Dear Editor,

We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Ne urons", which we wish to be considered for publication in Nature Neuroscience.

GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In t his paper, we report an unexpected, acute effect of GDNF on A-type potassium ch annels, leading to a potentiation of neuronal excitability, in the dopaminergic neuron s in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Th us, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. Thes e results may also have implications in the treatment of Parkinson’s disease.

Due to a direct competition and conflict of interest, we request that Drs. XXX of H arvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks fo r your consideration, I am

Sincerely yours,

case2

Dear Editor,

We would like to submit the enclosed manuscript entitled "Ca2+-binding protein freq uenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter releas e", which we wish to be considered for publication in Neuron.

We believe that two aspects of this manuscript will make it interesting to general r eaders of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first phy siological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enh ancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and fre quenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading t o an enhancement of Ca2+ influx. Thus, this study has identified, for the first time,

a molecular target that mediates the long-term, synaptic action of a neurotrophic f actor. Our findings may also have general implications in the cell biology of neurotr ansmitter release.

[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example used is the IJEB] Case 3

Sample Cover Letter[the example used is the IJEB]

Dear Editor of the [please type in journal title or acronym]:

Enclosed is a paper, entitled "Mobile Agents for Network Management." Please acc ept it as a candidate for publication in the [journal title]. Below are our responses t o your submission requirements.

1. Title and the central theme of the article.

Paper title: "Mobile Agents for Network Management." This study reviews the conce pts of mobile agents and distributed network management system. It proposes a m obile agent-based implementation framework and creates a prototype system to de monstrate the superior performance of a mobile agent-based network over the conv entional client-server architecture in a large network environment.

2. Which subject/theme of the Journal the material fits

New enabling technologies (if no matching subject/theme, enter 'Subject highly relat ed to [subject of journal] but not listed by [please type in journal title or acronym])

3. Why the material is important in its field and why the material should be publish ed in [please type in journal title or acronym]?

The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network mana gement system

has become increasingly important today's distributed environment. However, the co nventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobile

agent technology to assist the distributed management has emerged. The mobile a gent reduces network traffic, distributes management tasks, and improves operation

al performance. Given today's bandwidth demand over the Internet, it is important f or the [journal title/acronym] readers

to understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in t he literature that reports the analysis of network performance based on an operatio nal prototype of mobile agent-based distributed

network. We strongly believe the contribution of this study warrants its publication i n the [journal title/acronym].

4. Names, addresses, and email addresses of four expert referees.

Prof. Dr. William Gates

Chair Professor of Information Technology

321 Johnson Hall

Premier University Lancaster, NY 00012-6666, USA

phone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: wgates@https://www.360docs.net/doc/0f14905444.html, Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Intercon nection") in CACM, 38(3), pp. 188-198.

Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.

Assoc Prof. Dr. John Adams

Director of Network Research Center

College of Business Australian University

123, Harbor Drive Sydney,

Australia 56789

phone: +61-8-8888-8888 - fax: +61-8-8888-8886

e-mail: jadams@https://www.360docs.net/doc/0f14905444.html,.au

Expertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18 (8), pp. 88-98.

Relationship: None. I have never met Dr. Adams.

Assoc Prof. Dr. Chia-Ho Chen

Chair of MIS Department

College of Management

Open University

888, Putong Road

Keelung, Taiwan 100

phone: +886-2-8888-8888 - fax: +886-2-8888-8886

e-mail: chchen@https://www.360docs.net/doc/0f14905444.html,.tw

Expertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.

Relationship: Former professor, dissertation chairman.

Mr. Frank Young

Partner, ABC Consulting

888, Seashore Highway

Won Kok, Kowloon

Hong Kong

phone: +852-8888-8888 - fax: +852-8888-8886

e-mail: fyoung@https://www.360docs.net/doc/0f14905444.html,

Expertise: Mr. Young provides consulting services extensively to his clients regardin g network management practices.

Relationship: I have worked with Mr. Young in several consulting projects in the pa st three years.

Finally, this paper is our original unpublished work and it has not been submitted t o any other journal for reviews.

Sincerely,

Johnny Smith

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英文论文投稿信Cover letter模板 qiusuo BY - 2006-1-17 8:59:00 Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours, case2 Dear Editor, We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a

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