磁敏感加权成像在中枢神经系统疾病中的应用进展

磁敏感加权成像(SWI)在帕金森病

磁敏感加权成像（SWI）在帕金森病的应用 【摘要】目的：磁敏感加权成像（SWI）在帕金森病诊断中的应用，分析其临床应用价值，为帕金森病的临床诊断手段提供一定的参考依据。方法：选取2015年1月到2016年1月期间本院经过全面检查确诊为帕金森病患者35例作为实验组研究对象，再选取同期来本院体检的非帕金森病健康人30例作为对照组研究对象，两组研究对象分别采取磁共振成像系统行常规的快速自旋回波T1、T2加权像后，进行尾状核头、苍白球、壳核、黑质以及红核等对比，同时观察不同级别帕金森病患者的尾状核头、苍白球、壳核、黑质以及红核等差异，分析磁敏感加权成像（SWI）在帕金森病诊断中的应用，为帕金森病的临床诊断手段提供一定的参考依据。结果：经过磁共振（SWI）系统常规快速自旋回波T1、T2加权像后，实验组帕金森病患者的壳核相位值的平均数和标准差（-0.1071±0.0512）与对照组的 （-0.0832±0.0327）相比差异具有统计学意义（P<0.05），实验组患者的黑质相位值的平均数和标准差（-0.1092±0.0503）与对照组的（-0.0835±0.0224）相比差异具统计学意义（P<0.05），实验组患者与对照组的尾状核头、苍白球以及红核相比差异没有统计学意义（P>0.05）。Ⅰ~Ⅱ级帕金森病患者、Ⅲ级帕金森病患者以及Ⅳ级帕金森病患者之间的苍白球、壳核以及黑质等相位值的平均数和标准差比较差异具有统计学意义（P<0.05），Ⅰ~Ⅱ级帕金森病患者、Ⅲ级帕金森病患者以及Ⅳ级帕金森病患者之间的尾状核头和红核之间比较差异没有统计学意义（P>0.05）。结论：帕金森病患者经过磁共振成像系统行常规的快速自旋回波T1、T2加权像后显示壳核和黑质与正常人相比明显降低，且帕金森病患者随着病情等级的升高苍白球、壳核以及黑质呈降低状态，表明磁敏感加权成像（SWI）在帕金森病中具有一定的应用价值。 【关键词】磁敏感加权成像（SWI）；帕金森病；灰质核团；应用研究 The application of susceptibility weighted imaging (SWI) in Parkinson's disease [Abstract] Objective:Application of magnetic susceptibility weighted imaging (SWI) in the diagnosis of Parkinson's disease, analysis of its clinical application value, to provide reference for the clinical diagnosis of Parkinson's disease. Methods: From January 2015 to January 2016, 35 cases of patients with Parkinson's disease were selected as the experimental group, and the results were confirmed as the experimental group,in the same period, 30 patients with non Parkinson's disease in our hospital were selected as the control group, two groups of subjects were taken magnetic resonance imaging system for T2 weighted fast spin echo T1, like conventional, was the head of caudate nucleus, putamen, globus pallidus and substantia nigra, red nucleus contrast, at the same time, observe the head of caudate nucleus, different levels of patients with Parkinson's disease globus pallidus, putamen, substantia nigra, red nucleus and other differences, analysis of magnetic susceptibility weighted imaging (SWI) in the diagnosis of Parkinson's disease, to provide reference for the clinical diagnosis of Parkinson's disease. Results: After the magnetic resonance (SWI) system, the conventional fast spin echo T1, T2 weighted image, the mean and