AGI-5198_1355326-35-0_DataSheet_MedChemExpress

Product Name:

AGI-5198CAS No.:

1355326-35-0Product Data Sheet

Cat. No.:

HY-18082MWt:

462.56Formula:

C27H31FN4O2Purity :

>98%

Solubility:Mechanisms:

Biological Activity:

Pathways:Metabolism/Protease; Target:Isocitrate dehydrogenase DMSO

g y AGI-5198(IDH C35) is a novel R132H-IDH1 inhibitor, identified through a high-throughput screen

blocked R132H-IDH1 activity in a dose-dependent manner.

IC50 Value: The ability of the mutant enzyme (mIDH1) to produce R-2-hydroxyglutarate (R-2HG). The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered

metabolism of cancer cells for cancer therapy. Isocitrate dehydrogenase 1 (IDH1) is one potential

drug target, which is mutated in multiple human cancers [1].References:

[1]. Rohle D, Popovici-Muller J, Palaskas N, An inhibitor of mutant IDH1 delays growth and promotes

differentiation of glioma cells. Science. 2013 May 3;340(6132):626-30.

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

https://www.360docs.net/doc/7d12525731.html,

18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A

E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m