去乙酰毛花苷作用机制 - Medchemexpress - MCE中国

Deslanoside Cat. No.:

HY-A0154CAS No.:

17598-65-1分?式:

C??H??O??分?量:

943.08作?靶点:

Na+/K+ ATPase; Drug Metabolite 作?通路:

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease 储存?式:Powder

-20°C 3 years 4°C 2 years In solvent -80°C

6 months -20°C 1 month BIOLOGICAL ACTIVITY

?物活性Deslanoside (Desacetyllanatoside C) 是?种快速作?的强?苷，?于治疗充?性??衰竭和因折返机制引起的室上性

?律失常，并在治疗慢性?房颤动时控制?室率。Deslanoside 抑制Na-K-ATPase 膜泵，导致细胞内钠和钙浓度增加。

体外研究Deslanoside (Desacetyllanatoside C) is a metabolite of Lanatoside C [4]. Deslanoside increases forearm blood flow and

cardiac index and decreased heart rate concomitant with a marked decrease in skeletal muscle sympathetic nerve

activity measured as an indicator of centrally mediated sympathetic nervous system activity [1].

REFERENCES

[1]. Hauptman PJ, et al. Digitalis. Circulation. 1999 Mar 9;99(9):1265-70.

[2]. Wang L, et al. Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China. Sci Rep. 2017 Oct 23;7(1):13819.

[3]. Deslanoside.

[4]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

[5]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.McePdfHeight

Caution: Product has not been fully validated for medical applications. For research use only.

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