Terbinafine hydrochloride_78628-80-5_DataSheet_MedChemExpress

Product Name:

Terbinafine hydrochloride CAS No.:

78628-80-5Cat. No.:

HY-17395Product Data Sheet

MWt:

327.89Formula:

C21H26ClN Purity :>98%

Solubility:

DMSO 10 mg/ml Ethanol 30 mg/ml

y Mechanisms:

Biological Activity:

Terbinafine Hcl is a synthetic allylamine antifungal which is highly active against dermatophytes

Pathways:Anti-infection; Target:Antifungal Terbinafine Hcl is a synthetic allylamine antifungal, which is highly active against dermatophytes,

mold, other basic fungi, and some strains of yeast.

IC50 value:

Target: antifungal; squalene epoxidase Terbinafine hydrochloride is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for

C. albicans). Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. At 90-120 ?M, Terbinafine exhibits anti-tumor and anti-angiogenic activity by inducing cell cycle arrest at the G0/G1 stage in References:

[1]. Tayel SA, El-Nabarawi MA, Tadros MI, et al. Promising ion-sensitive in situ ocular nanoemulsion gels of terbinafine hydrochloride: Design, in vitro characterization and in vivo estimation of the ocular irritation and drug pharmacokinetics in the aqueous humor of rabbits. Int J Pharm. 2013 Jan 16. pii:g g y y g y g COLO 205 tumor cells and human vascular endothelial cells....

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S0378-5173(13)00013-6.[2]. Tanr?verdi ST, Ozer O. Novel topical formulations of Terbinafine-HCl for treatment of

onychomycosis. Eur J Pharm Sci. 2013 Jan 4. pii: S0928-0987(12)00488-5.[3]. Motavaze K, Namvar Z, Emami M, et al. Molecular characterization of a Squalene epoxidase

gene in dermatophyte pathogen Trichophyton tonsurans. Iran Biomed J. 2008 Jan;12(1):55-8.[4]. Ho PY, Liang YC, Ho YS, et al. Inhibition of human vascular endothelial cells proliferation by

terbinafine. Int J Cancer. 2004 Aug 10;111(1):51-9.[5]. Ryder NS. Terbinafine: mode of ...

Caution: Not fully tested. For research purposes only

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