M5-brane geometries, T-duality and fluxes

M5-brane geometries, T-duality and fluxes
M5-brane geometries, T-duality and fluxes

a r X i v :h e p -t h /0307156v 1 17 J u l 2003FTUAM-03/13,IFT-UAM/CSIC-03-25

hep-th/0307156

M5-brane geometries,T-duality and ?uxes Juan F.G.Cascales 1,Angel M.Uranga 21Departamento de F′?sica Te′o rica C-XI and Instituto de F′?sica Te′o rica,C-XVI Universidad Aut′o noma de Madrid Cantoblanco,28049Madrid,Spain juan.garcia@uam.es 2IMAFF and Instituto de F′?sica Te′o rica,C-XVI Universidad Aut′o noma de Madrid Cantoblanco,28049Madrid,Spain angel.uranga@uam.es We describe a duality relation between con?gurations of M5-branes in M-theory and

type IIB theory on Taub-NUT geometries with NSNS and RR 3-form ?eld strength ?uxes.The ?ux parameters are controlled by the angles between the M5-brane and the (T)duality directions.For one M5-brane,the duality leads to a family of supersymmet-ric ?ux con?gurations which interpolates between imaginary self-dual ?uxes and ?uxes similar to the Polchinski-Strassler kind.For multiple M5-branes,the IIB con?gurations are related to ?uxes for twisted sector ?elds in orbifolds.The dual M5-brane picture also provides a geometric interpretation for several properties of ?ux con?gurations (like the supersymmetry conditions,their contribution to tadpoles,etc),and for many non-trivial e?ects in the IIB side.Among the latter,the dielectric e?ect for probe D3-branes is dual to the recombination of probe M5-branes with background ones;also,a picture of a decay channel for non-supersymmetric ?uxes is suggested.

1Introduction

String and M-theory backgrounds with?eld strength?uxes for various p-form gauge ?elds have been shown to lead to interesting features[1,2,3,4,5].For instance, scalar potentials with non-trivial minima leading to moduli stabilization,supergravity descriptions in terms of warped geometries,and(possibly partial)breaking of super-symmetry.These con?gurations are presently under intense study from diverse points of view.In this paper we would like to present a new approach to their analysis in terms of a new dual picture.

We describe a duality between con?gurations of M-theory M5-branes and type IIB string theory on Taub-NUT geometries with a background of NSNS and RR3-form ?eld strength?uxes.Data of the?ux con?guration,and many of its properties,are encoded in simple properties of the geometry of the dual M5-brane con?guration.

The duality is a generalization of the relation between parallel M5-branes in M-theory and Taub-NUT geometries in IIB theory,which we review in Section2.In Section3we present our duality and show that M5-branes at angles with respect to the duality directions are related to Taub-NUT geometries with a non-trivial background of3-form?uxes,controlled by the dual angle parameters(sections3.1.1and3.1.2).

These con?gurations are interesting for several reasons.Di?erent properties of the IIB backgrounds are encoded in the M5-brane geometry,for instance?ux quantization conditions(section3.1.3),and charges induced by the?ux background(section3.1.4). Moreover,in Section3.1.5we argue that the IIB duals to single stacks of M5-branes preserve16supersymmetries,and provide a family of backgrounds that interpolate between imaginary self-dual?uxes with constant dilaton and more general supersym-metric?ux con?gurations with varying dilaton,reminiscent of those in[6].

In section3.2we discuss multiple M5-brane stacks,for which the M-theory dual provides a description of twisted?uxes on C2/Z N orbifold singularities.Again some features like moduli stabilization or the supersymmetry of the con?guration are ex-plained using the M5-brane geometry(section3.2.2).The M-theory picture can be also used to suggest decay mechanisms for non-supersymmetric?uxes(section3.2.3), and the stabilization by?uxes of unstable non-Calabi-Yau geometries(section3.2.4).

In section3.3we discuss the M-theory picture of diverse e?ects when one introduces D3-brane probes in the IIB?ux background,for instance,the appearance of4d N=2 soft masses(section3.3.1),and Myers dielectric e?ect[7](section3.3.2).A prominent role is played by the process of recombination of intersecting M5-branes.Finally,in section4we discuss generalizations of the above duality to threefold geometries related

to the conifold.Section5contains our?nal comments.

2M5-brane vs.Taub-NUT

In this section we review the geometry of Taub-NUT and its duality relation with M-theory M5-branes.

2.1A few facts on Taub-NUT

The N-center Taub-NUT metric is(see e.g.[8]for a useful reference)

ds2=H( x)?1(dy+ωi dx i)2+H( x)d x2

H( x)=1+

N

a=1H a( x);H a( x)=1

dual to the2-cyclesΣab(with suitable orientation).In the limit of in?nite asymptotic radius,the geometry corresponds to an N-center ALE geometry,namely a(generically blown-up)C2/Z N orbifold.In this limit,the form?becomes non-normalizable,and can be regarded as a constant2-form inherited from the covering C2.The forms

1

?k=

,and x a denote the M5-brane locations in789.For

| x? x a|

simplicity we consider the case of coincident centers x a=0,for which H5=1+N

we obtain the IIA background

ds2IIA=ds2012345+H5ds26789

e2φ=H5

B NS=ωdx6(2.8)

Application of T-duality formulae in appendix A,leads to the type IIB background ?elds

τIIB=a+ie?φ=i

ds2IIB=ds2012345+H?15(r)(dx6+ωi dx i)2+H5(r)d x2(2.9)

This corresponds to a purely metric background,corresponding to a Taub-NUT geometry(2.1)with N coincident centers.The IIB complex coupling takes the value τ=i because we took equal radii for the6,10circles.Applying the dualities to the background with general radii leads toτ=iR6/R10.

The general mapping of parameters between both con?gurations is as follows.The location of the a th M5-brane in7,8,9maps to the position x a of the a th Taub-NUT center in the base R3.The location of the a th M5-brane in6,10is mapped to the component of the NSNS and RR2-form?elds along?https://www.360docs.net/doc/f415349345.html,ly,the positions (normalized w.r.t.the total radius,i.e.φi=x i/R i)correspond to the coe?cientsφ6a,φ10a in the expansion

B NSNS= aφ6a?a;B RR= aφ10a?a(2.10) See[11]for further discussion.The bottomline of this section is that simultaneous shrinking of the directions6,10in the M5-brane con?guration leads to IIB theory on a Taub-NUT geometry.

3M5-brane geometries and?uxes

In this section we consider a generalization of the above duality.It is a duality between con?gurations of M5-branes at angles and Taub-NUT geometries with3-form?eld strength?uxes.Intuitively,the amount of rotation of a given M5-brane with respect to the4,5coordinates will map to the amount of NSNS and RR?ux turned on along the corresponding harmonic2-form in the dual Taub-NUT geometry.Thus,many features of?uxes are easily geometrized into con?gurations of M5-branes.

Figure1:Con?guration of M5-brane at angles(with respect to the duality directions).

3.1Single M5-brane

3.1.1Intuitive T-duality

Let us start by considering an intuitive explanation of the basic duality we explore in the present paper.Let us regard the M-theory spacetime as the product of a M4 (spanned by0123),times R×S1(spanned by46),times R×S1(spanned by510), times an R3(spanned by789).Consider a single M5brane with volume spanning M4 times a real line in each of the R×S1factors.We denote byθ1,θ2the angle between these lines and the directions4and5,respectively.See?gure1.

Let us shrink the directions6,10and obtain the corresponding dual type IIB con-?guration.In order to do that,it is useful to regard the original M-theory con?guration as that of one M5-brane spanning0,1,2,3,4,5and with a non-trivial pro?le for the world-volume scalarsφ6,φ10that encode the location of the M5-brane in the directions 6,10,of the form

φ6=tanθ1x4;φ10=tanθ2x5(3.1)

Under the duality,we obtain the IIB theory on a Taub-NUT geometry.Recall that the scalars are mapped to the components of B NSNS,B RR along?.The linear variation of these scalars with x4,x5then implies that there are non-trivial NSNS and RR3-form ?eld strength?uxes turned on the Taub-NUT,roughly of the form

H3=tanθ1?dx4;F3=tanθ2?dx5(3.2)

(Normalization can easily be?xed from?ux quantization conditions,see section3.1.3).

The generalization to N parallel M5-branes is straightforward,namely the IIB dual is given by an N-center Taub-NUT space,with?uxes(3.2)along the overall(untwisted) 2-form?.

4Figure 2:Pictorial depiction of the e?ect of changing coordinates.The directions which are shrunk in the duality are at ?xed values of the new coordinates x ′4,x ′5,hence correspond to the Killing directions k 6,k 10.Hence we are describing a (T)duality of the M5-brane con?guration along directions at angles with the latter.The angles θ1,θ2are determined by the coordinate change parameters ξ6,ξ10.In order to avoid annoying minus signs in our formulas,we consider clockwise angles as positive.

Hence we have found a duality relation between con?gurations of 3-form ?eld strength ?uxes in Taub-NUT space and the geometry of the M5-brane.The above analysis is however oversimpli?ed,e.g.it ignores the backreaction of the ?uxes in the geometry.In next section we describe a more careful application of T-duality,that reproduces these e?ects.

3.1.2Detailed duality relation

Let us derive the above duality relation with an argument closer to that in section

2.2.Consider the supergravity solution corresponding to M5-branes along 012345,in a background Minkowski metric,(2.6).In order to introduce the above tilting of the M5-brane,let us perform the change of variables

x 4=x ′4+ξ6x 6;x 5=x ′5+ξ10x 10(3.3)

As shown in ?gure (2),this implies that the M5-brane is along directions at angles with respect to the directions along which we perform the dualities.

The metric becomes

ds 211d =H ?1/3

5ds 20123+H 2/35ds 2789+H ?1/35(H 5+ξ26)(dx 6)2+H ?1/35(H 5+ξ210)(dx 10)2+H ?1/35(dx ′4)2+H ?1/35(dx ′5)2+2ξ6H ?1/35dx ′4dx 6+2ξ10H ?1/35dx ′5dx 10(3.4)

Let us ignore for the moment the e?ect of the coordinate change in the 3-form

background,and take C 3=ωdx 6dx 10.Its full discussion is postponed to section 3.1.4.Also,in what follows,we drop the primes of the new 45coordinates.

Upon reduction to IIA,we obtain the background

e 4φ/3=H ?1/35

(H 5+ξ210)A 5=ξ10

H 5+ξ210 1/2

B NSNS =?ξ6H 5+ξ210(dx 6+ωi dx i )∧dx 5(3.7)

Again,more careful discussion of the M-theory 3-form (see section 3.1.4)introduces additional pieces in the above 2-forms.

As discussed above,it corresponds to a (deformed)Taub-NUT background with 3-form ?uxes.Note that the ?ux densities are controlled by the parameters ξ6,ξ10.Their ?eld strengths

H 3=?ξ6[d (H 5+ξ26)?1(dx 6+ω)+(H 5+ξ26)?1dω]∧dx 4

F 3=?ξ10[d (H 5+ξ210)?1(dx 6+ω)+(H 5+ξ210)?1dω]∧dx 5(3.8)

correspond to harmonic2-forms in the above deformed geometry,in the following sense.As the?ux parameters approach zeroξ6,ξ10→0(and the metric approaches the undeformed Taub-NUT and the dilaton becomes constant),the?eld strengths are proportional to the harmonic2-form(2.5).A sketchy description of the con?guration is,therefore,a Taub-NUT geometry with3-form?uxes(3.2).Namely,the tilting of the M5-brane with respect to the(T)duality directions in46,and510,turns into NSNS and RR3-form?uxes,respectively,in the dual IIB con?guration.Further backreaction of the?uxes on the geometry leads to a squashing of the latter,which appears at quadratic order in the?ux perturbation.

The generalization of the duality relation is clear.Type IIB on a Taub-NUT geom-etry,with3-form?uxes2

H3=?(a1dx4+a2dx5)

F3=?(a3dx4+a5dx5)(3.9)

is dual to a con?guration of M5-branes with volume spanning M4times the2-plane de?ned by x6=a1x4+a2x5,x10=a3x4+a5x5.

The generalization to arbitrary complex IIB coupling is similar,by introducing an arbitrary mixing between the coordinates6,10in(3.3),via a change of variables x6=x′6+ρ10x10.The full IIB solution may be found from the above supergravity background by performing an SL(2,R)transformation.A sketchy description is that the familiar3-form?ux combination G3=F3?ΦH3(withΦthe IIB complex coupling) plays the role of the M5-brane position in the complex plane z=x10?Φx6.For simplicity we will restrict to the above situation with zero axion in most of the paper.

Hence,we have found a duality relation that provides a geometric interpretation for3-form?uxes in Taub-NUT geometries.In the following we discuss the geometric interpretation of diverse properties of?uxes.For simplicity,we center on?uxes of the form(3.2),rather than(3.9).

3.1.3Flux quantization

Consider a1center Taub-NUT geometry and take the directions4,5to be compacti?ed on a rectangular two-torus,so that x4,x5have lengths R4,R5.Let us introduce the 1-forms dφ4=dx4/R4,dφ5=dx5/R5,with period1over the non-trivial cycles in this

two-torus.In this compact setup,consistency of the con?guration requires the3-form ?uxes H3,F3to be quantized.At linear order(i.e.in the’?ux probe’approximation) this can be phrased as

H3=k6?dφ4+k′6?dφ5(3.10)

with k6,k′6∈Z,and analogously for F3(with coe?cients k′10,k10).Namely the?uxes must de?ne integer cohomology classes.

The quantization of?uxes has a very natural interpretation in the dual M-theory con?guration.Consider for simplicity?uxes H3=k6?dφ4,F3=k10?dφ5.Recalling the interpretation of the?ux coe?cients as dual positions(2.10),we have

?φ6

R4;

?φ10

R5

(3.11)

This implies that the total wrapping number of the M5-brane in the direction6,as one winds around the direction4,is an integer

R40(?φ6/?x4)dx4=k6(3.12) and analogously for the wrapping number of the M5-brane in10as one moves in5.

Integrality of the cohomology class of the3-form?uxes is thus dual to the integrality of the homology class of the M5-brane,namely that the wrapping numbers along the cycles of the compact directions should be integers.

3.1.4Induced charges

An interesting property of NSNS and RR3-form?uxes is that their wedge product acts as a source for the https://www.360docs.net/doc/f415349345.html,ly,the combination of?uxes carries an induced D3-brane charge.In fact,these are not the only induced charges carried by our?ux con?gurations.In this section we describe them and their dual geometric interpretation.

In order to have?nite charges we need to consider,as above,compact4,5directions, which we take of unit length for simplicity.Consider in the M-theory picture an M5-brane wrapped along one1-cycle in the4-6two-torus and along one1-cycle in the5-10 two-torus.The charges of the con?guration are described by the homology class

[Π]=(k4[a4]+k6[a6])?(k5[a5]+k10[a10])=(3.13) =k4k5[a4]?[a5]+k6k10[a6]?[a10]+k4k10[a4]?[a10]+k6k5[a6]?[a5] where k i∈Z and[a i]is the1-cycle along the i th direction.

The charge k4k5is mapped to the Taub-NUT charge(i.e.number of centers)in the type IIB dual.The charge k6k10should in principle be mapped to a D3-brane charge in the IIB dual.Indeed,this is the induced charge due to the3-form?uxes,as follows from

N D3= T N×T2H3∧F3=tanθ1tanθ2 T N?∧? T2dx4dx5=

=k4k5tanθ1tanθ2=k6k10(3.14) Hence we have found a geometric interpretation for the4-form charge carried by3-form ?uxes.

There remains to interpret the charges k4k10and k6k5.They correspond to charges of D5-branes spanning46and NS5-branes spanning56,respectively.Their presence can be understood from the central charge formula for the con?guration.General results(see[12]or section3.1.in[13])imply that an N-center Taub-NUT geometry with a p-form background asymptotically along x6develops an induced charge of the corresponding magnetic object.In our context,a Taub-NUT charge N=k4k5in the presence of a NSNS2-form asymptoting toξ6dx4dx6develops Q units of induced charge of NS5-brane along012356,with

Q=ξ6k4k5=tanθ1k4k5=k6k5,(3.15) as required.Analogously for the D5-brane charge induced by the RR2-form back-ground.

In the following we rederive these results.Indeed,all the induced charges are correctly reproduced once we take into account the change of the M-theory3-form background under the coordinate change(3.3),ignored in section(3.1.2)for simplicity.

After the coordinate reparametrization(3.3),the11d background3-form becomes C3=ωdx6dx10?ξ6ωdx4dx10?ξ10ωdx6dx5+ξ6ξ10ωdx4dx5(3.16) Upon reduction to IIA,we obtain the p-form background

B NSNS=ωdx6?ξ6ωdx4

C3=?ξ10ωdx6dx5+ξ6ξ10ωdx4dx5(3.17) Further T-duality along the direction6leads to

ξ6

B NSNS=?

(dx6+ωi dx i)∧dx5+ξ10ω∧dx5

H5+ξ210

C4=ξ10 ξ6+ξ6

As we now show,the additional pieces in the p-form background contain the additional induced charges discussed above.We sketch their computation,using expressions cor-rect to the corresponding order in the?uxes(linear for the NS5-,D5-brane charges, quadratic for the D3-brane charge).The NS5-and D5-brane charges can be obtained by integration of the NSNS resp.RR?eld strength3-forms over the3-cycles of the form S2times the direction x4resp.x5,where the S2is a2-sphere in the R3base of Taub-NUT,surrounding the centers.This integral vanishes for the?rst piece of the ?eld strengths(3.8),since they are harmonic and the3-cycle is homologically trivial. Using(2.2),the integral of the new piece however gives

S2×(S1)4ξ6dωdx4=k4k5ξ6=k5k6(3.19) for the NSNS?eld,and analogously for the RR?eld.Hence we recover the correct charges.

The induced D3-brane charge is computed similarly.The charge arises from inte-grating the5-form?ux over the45two-torus times a large S3in Taub-NUT.The latter is obtained from the S1?bration over an S2in the base.Recalling the modi?cation of the5-form?eld strength due to Chern-Simons couplings,

?F 5=dC4?

1

2

F3∧B NSNS(3.20)

we have

S3×T2?F5= T N×T2d?F5= T N×T2H3∧F3(3.21) namely the familiar contribution to the tadpole for the4-form.In our background,the 3-form?uxes have the structure

H3=?ξ6?∧dx4?ξ6dω∧dx4;F3=?ξ10?∧dx5+ξ10dω∧dx5(3.22)

Out of the four contributions to H3∧F3,the piece proportional to dω∧dωdoes not contribute to the integral in(3.21),and the two pieces proportional to?∧dωcancel each other.The induced D3-brane charge arises from the piece proportional to ?∧?leading to a total charge of k4k5ξ6ξ10=k6k10,as in the naive discussion(3.14). Hence our?ux con?guration correctly accounts for all induced charges of the system. Alternatively,the M5-brane homology class provides a simple geometric interpretation for them.

In the above con?guration the homology charges,q ij,coe?cients of the terms [a i]?[a j]in[Π],satisfy the quadratic constraint q45q610=q410q65.This follows from the

factorized form of the wrapped2-cycle,and implies that the system preserves1/2super-symmetry.It is natural to wonder about M5-brane con?gurations were the homology charges q ij do not satisfy a quadratic constraint.As discussed in[14],they correspond to M5-branes wrapped on non-factorizable holomorphic2-cycles,which preserve1/4of the supersymmetries.These con?gurations are easily obtained from recombination of factorizable M5-branes intersecting at angles not de?ning an SU(2)rotation.The IIB dual of such systems is brie?y discussed in section3.2.3.

3.1.5Supersymmetry

Another interesting property of?ux con?gurations is the amount of supersymmetry that they preserve.There exist in the literature several classes of supersymmetric ?uxes(see e.g.[15]),but a uni?ed understanding of them is lacking.In this section we argue that our IIB?ux con?gurations provide a family of supersymmetric?uxes that interpolates between two classes of familiar supersymmetric con?gurations3.

Indeed,considering the case ofξ6=±ξ10≡ξ,our?ux background G3=F3?ΦH3 (withΦthe IIB complex coupling)satis?es the imaginary self-(or anti-self-)duality condition:

G3=±i?6d G3(3.23)

In fact,the?uxes can be seen to be(2,1)[or(1,2)]and primitive.Moreover the dilaton-axion?elds are constant,and the metric takes the form

ds2IIB=H?1/2

5(H5+ξ2)1/2ds20123+H1/2

5

(H5+ξ2)?1/2 (dx4)2+(dx5)2+

+(H5+ξ2)ds2789+(H5+ξ2)?1(dx6+ω)2 (3.24)

It is a warped version of M4times R2

(45)

times the Taub-NUT.This background is a particular case of the class considered in section3in[15]generalizing the?uxes in[16] (and which also appears in compact models,see e.g.[3]).

On the other hand,forξ6=ξ10,the?ux G3does not have any particular self-duality property,the dilaton has a non-trivial pro?le,and the metric deviates from the warped ansatz.However,although the con?guration is more involved,the M-theory picture implies that it is supersymmetric as well(preserving16supercharges).On one hand the initial M5-brane con?guration is clearly supersymmetric,and due to the smearing,

the constant spinors do not depend on the duality coordinates610,hence are also preserved in the dual IIB image[17].From a di?erent point of view,the con?guration satis?es the equations of motion,i.e.minimizes the energy,in a sector where the central charges satisfy a quadratic constraint,hence ensuring that the energy-minimizing state is1/2BPS,namely preserves16supersymmetries.It would be interesting to verify explicitly that the supersymmetric variations vanish in our background.

This more general class of supersymmetric?uxes,with varying dilaton,is highly reminiscent of the?ux con?gurations appeared in[6]and studied in[15](to?rst order in the?uxes).Indeed,the supersymmetries preserved correspond to the supersymmetry preserved by bound states of D3-branes and5-branes.Moreover,as we discuss in section3.3,such?uxes induce mass terms and dielectric polarization on D3-brane probes when the latter are introduced,in close analogy to[6].Again,it would be interesting to perform a direct comparison with the latter reference.Some di?erences exist,however:our con?gurations preserve16supersymmetries,exist in Taub-NUT geometries,and are associated to N=2mass terms on D3-brane probes(while?uxes in[6]preserve four supercharges,are introduced in(warped)?at space,and correspond to N=1mass terms on D3-brane probes).

Leaving a more detailed discussion of this interesting property of our con?gura-tions for future work,we conclude by emphasizing that our duality provides a simple construction of a family of supersymmetric?ux con?gurations interpolating between well-known classes of supersymmetric?uxes.

3.1.6Relation to magnetized D6-branes

Another interesting dual realization of the above systems is obtained as follows.Con-sider type IIB on a Taub-NUT geometry in6789,momentarily without?uxes.Let us T-dualize along the direction3,to obtain IIA theory on a Taub-NUT background. Now perform a‘9-11?ip’,namely lift the con?guration to M-theory on a Taub-NUT background,and shrink the isometry direction of the latter;the resulting con?guration is a type IIA D6-brane.Let us now carry out the same exercise in the presence of type IIB3-form?uxes of the form(3.2).T-dualizing to IIA we obtain a Taub-NUT geometry with?uxes

H3=ξ6?dx4;G4=ξ10?dx3dx5(3.25) Lifting to M-theory,we obtain a Taub-NUT geometry with4-form?ux

G4=ξ6?dx4dx10+ξ10?dx3dx5(3.26)

This can be compared with?uxes in M-theory compacti?cations in[2].It is easy to recover di?erent properties of the latter from our description in terms of M5-brane geometries.

Reducing along the isometrical direction of Taub-NUT,we obtain a IIA D6-brane. Now recall that D6-brane world-volume gauge?elds arise from components of the M-theory3-form along the harmonic2-forms,i.e.of the type C3=?A1.We conclude that the con?guration includes D6-brane world-volume magnetic?elds

F2=ξ6dx4dx10+ξ10dx3dx5(3.27)

Namely there are constant magnetic?eldsξ6,ξ10in the2-planes410and35,respec-tively.The imaginary self-(or anti-self-)duality conditions on the original IIB?uxes correspond to the(anti)self-duality of the world-volume gauge background.This dual picture provide interesting complementary viewpoints on our previous discussion and our proposals below.

3.2Multiple M5-branes and twisted?uxes on orbifolds

3.2.1Relation to twisted?uxes in C2/Z N orbifolds

There is a natural generalization of the setup in section3.1,namely considering several M5-branes.Consider the M-theory picture,and introduce N M5-branes,labeled a= 1,...,N,spanning0123and the2-planes

x6=tanθ1,a x4

x10=tanθ2,a x5(3.28)

The dual IIB con?guration is given by an N-center Taub-NUT space,with3-form ?uxes along the harmonic2-forms?a,namely

H3=

N

a=1tanθ1,a?a dx4

F3=

N

a=1tanθ2,a?a dx5(3.29)

Generalizations are straightforward and will not be discussed explicitly.It is inter-esting to realize that we in general have?uxes in the compact non-trivial2-cycles of the https://www.360docs.net/doc/f415349345.html,ly,the projection of the?ux along a particular harmonic2-form ?ab is related to the relative angle between the corresponding dual M5-branes a,b. The M5-brane picture allows a reliable description of the system even in the limit of

coincident M5-branes,namely when the2-cycles are collapsed to zero size and the ge-ometry develops an orbifold singularity4.The present setup,therefore allows a reliable description of untwisted and twisted?uxes at orbifold singularities C2/Z N.The fact that the description and properties of the?uxes are reliable even in this large curva-ture regimes is clearly related to the large amount of supersymmetry preserved by the con?guration.

3.2.2Moduli stabilization and supersymmetry

One of the most interesting features of con?gurations with?uxes is that minimization of the vacuum energy density leads to a constraint on the?ux density,namely the?ux combination G3=F3?ΦH3(withΦthe IIB complex coupling)must be imaginary self-dual(or anti-self-dual)

G3=±i?6d G3(3.30)

Since,due to?ux quantization,?ux densities are functions of moduli,the above condi-tion?xes their vevs.In our particular context of?uxes in Taub-NUT geometries,the above condition is moreover equivalent to the conditions that the?ux G3is(2,1)[or (1,2)]and primitive(namely G3∧J=0).That is,the?ux preserves a particular su-persymmetry.In this section we discuss how the above condition,moduli stabilization, and supersymmetry,are encoded in the M-theory con?guration.

Consider compactifying the directions45in a two-torus,for simplicity rectangular, with x4,x5of lengths R4,R5.Consider a con?guration with two M5-branes,which we take without loss of generality at angles±(θ1,θ2)in the two-planes46and510, respectively.For simplicity,consider them to have wrapping numbers k6,k10along6, 10(and wrapping once along4,5).We have

ξ6=tanθ1=k6R6

R5

(3.31)

In the dual IIB picture we have a two-center Taub-NUT space with?uxes

H3=2k6?12dφ4;F3=2k10?12dφ5(3.32)

with?12=(?1??2)/2andφ4,φ5are de?ned as in https://www.360docs.net/doc/f415349345.html,ly,it corresponds to a con?guration with purely twisted?uxes.

Introducing the complex coordinate z=φ4+τφ5withτ=iR5/R4,we have

G3=2?12 dzτ(k10+Φzτ(?k10?Φτk6) (3.33)

The condition that G3is imaginary self-dual((2,1)and primitive)requires the last piece to drop,hence the dual of(3.30)is

k10R10

(3.34)

R4

namelyθ1=θ2.This is the familiar condition5that the rotation relating the two M5-branes is in SU(2).This is a condition of minimization of the energy of the two M5-brane system.When regarded as function of the moduli,the condition?xes the vevs of the latter,illustrating the dual version of moduli stabilization by?uxes.

Finally,for con?gurations of branes intersecting at two non-trivial angles,the en-ergy minimization conditions automatically imply the supersymmetry conditions.This is dual to the statement that in Taub-NUT spaces,(anti)self-duality of the?uxes au-tomatically implies supersymmetry of the con?guration.

3.2.3Stabilization of non-susy?ux con?gurations;enhancons

Branes intersecting at angles not in SU(2)relation su?er an instability against recombi-nation to a single smooth curve,whose volume is smaller than the original intersecting con?guration.This follows from analyzing the BPS formula for the system,or by using a dual intersecting D-brane con?guration.It is interesting to consider the interpreta-tion of this process in the IIB dual realization of this system.In this section we discuss this interpretation in the case of none of the branes being along the directions610 6.A useful approach to this instability is to consider the supersymmetric case?rst, where the recombination process is parametrized by a modulus.Let z=x4+ix5, w=x6+ix10.The intersecting con?guration is described by an M5-brane wrapped on a curve of the form(z?w)(z+w)=0,while in the recombined con?guration the brane wraps the cycle(z?w)(z+w)=?.

Consider as in section3.2.2two M5-branes at angles±(θ1,θ2)in the46and510 directions,respectively,with wrapping numbers(1,k6)and(1,k10),and which coin-cide in789.The dual con?guration contains a two-center Taub-NUT geometry,with coincident center,and with3-form twisted?uxes

H3=2ξ6?12dx4;F3=2ξ10?12dx5(3.35)

Forξ6=ξ10,the?ux con?guration is non-supersymmetric,and the M-theory picture suggests that it su?ers an instability.

The process involves somewhat exotic degrees of freedom.In the supersymmetric case,the degrees of freedom responsible for the restabilization of the con?guration are BPS states,and so can be translated directly from dual con?gurations of intersecting M5-or D-branes.It is easy to realize that they correspond to tensionless degrees of freedom from D3-branes wrapped on the collapsed2-cycleΣ12.D3-branes wrapped on theΣ12lead to tensionless objects because there are points in45where the integral of the2-form?elds overΣ12vanish.The number of such points,and hence of the massless degrees of freedom involved in the condensation,is given by4k6k10,in agreement with the number of intersection points in the dual.

The nature of the con?guration after condensation of these degrees of freedom is unclear,since it involves a Higgs e?ect for the2-form?elds.It is tantalizing to propose that its description in the IIB con?guration is related to the enhancon geometries[18], since it involves a shell region(dual to the region of recombination of the dual M5-branes)associated to massless D-brane degrees of freedom.Indeed,in M-theory the ?nal con?guration is an M5-brane wrapped on a single smooth curve.The IIB version of this kind of con?guration in theories with8supercharges has been discussed in[19]. It would be very interesting to develop these relations further.

Although the decay involves a con?guration not very familiar in the context of ?uxes,it is perfectly natural in other dual realizations of the system.Consider for instance the dual con?guration in section3.1.6,of D6-branes with world-volume mag-netic?uxes.In the non-supersymmetric case the abelian gauge background decays to an U(2)instanton involving the non-abelian degrees of freedom,arising from open strings stretching between the two branes.The non-abelian character of the?nal con-?guration is thus responsible for the di?culty in?nding a supergravity description on the IIB side.

Note that the above argument provides and answer to the question raised in section 3.1.4on the IIB dual to M5-branes wrapped on non-factorized holomorphic cycles. Interestingly,the latter provide a geometric picture of a somewhat mysterious process in IIB theory.

3.2.4Stabilization/supersymmetrization of non-susy geometries

There is an interesting dual realization of this kind of con?guration,in which one of the angle parameters maps to a?ux background,while the second angle leads to a

non-Calabi-Yau geometry in the dual.The full con?guration is however stable and supersymmetric,due to a compensating e?ect of the?ux and the geometry.

Consider two M5branes spanning0123,at angles±(θ1,θ2)in the2-planes46and 510,and located at points in789.Consider the coordinate9to be compact,and consider reducing to a type IIA con?guration by shrinking it.We obtain two IIA NS5-branes spanning0123,at anglesθ1in46andθ2in510.Let us now perform a T-duality along the direction10.In the case ofθ2=0,the T-dual con?guration is a purely geometric background that corresponds to a non-supersymmetric and unstable back-ground,described by a5d geometry X5,considered in[20].Intuitively,it corresponds to two Taub-NUTs intersecting in a non-supersymmetric fashion.The con?guration contains an instability localized at the singular point at the intersection.The relaxation of the instability was shown to correspond to a dynamical resolution of the singularity, leading to a smooth geometry with a non-trivial2-sphere,which in the non-compact case runs away to in?nite size.

For non-zeroθ2,the new non-trivial angle does not modify the topology dual ge-ometry.The IIB con?guration is given by a squashed version of the same topological manifold X5,which in addition now contains a non-zero NSNS3-form?ux.

For the caseθ1=±θ2,namely for a3-form?ux tuned to the5d geometry,the con?guration is supersymmetric.In this sense,the introduction of the3-form?ux stabilizes the geometry X5.In fact,the unstable direction,which corresponds to increasing the size of the non-trivial2-sphere,is a modulus direction(dual to the recombination of the two intersecting branes in the susy case).It is interesting to notice that in the large volume limit of this modulus,supergravity is reliable and the stabilization mechanism is amenable to explicit analysis.

Clearly SL(2,R)transformations of the above con?guration(equivalently,shrinking the directions910in di?erent fashions)show that the stabilization can be achieved for a suitably tuned amount of RR?ux or a combination of NSNS and RR?uxes.

Although the above non-supersymmetric geometries are not of orbifold kind,it is tempting to speculate that?ux con?gurations in non-supersymmetric orbifold may also lead to the stabilization of such geometries(although perhaps not in a supersymmetric fashion).This presumably arises from the competition of the tachyonic nature of twisted sector scalars and the contribution to their potential generated by a background of twisted?uxes.It would be interesting to analyze this idea in more detail.

3.2.5Dualities to conifolds

Finally,we would like to point out that the above con?gurations admit a dual ver-sion where both angles become properties of the geometry;indeed,the con?gurations are dual to a purely geometric background containing a conifold singularity.Consider two M5-branes intersecting at SU(2)angles7,and consider compactifying,and sub-sequently shrinking,the directions78.For instance,shrinking along8,we obtain a con?guration of intersecting IIA NS5-branes;and T-dualizing along7,we obtain[21] IIB theory on a singular geometric background with a conifold singularity.

Notice that the two dualities are related in the M-theory picture by an exchange of the directions67and810,namely a simultaneous SL(2,Z)transformation in the corresponding two two-tori.In the IIB picture,the con?guration of Taub-NUT with ?uxes and the conifold geometry are thus related by a U-duality transformation.It is clear that one can generate even more duals by choosing to dualize along other intermediate directions in the two-tori67and810.All these would?ll out a multiplet of highly non-trivial con?gurations under U-duality.

3.3D-brane probes

In this section we consider several properties of the physics of D3-brane probes in the above Taub-NUT plus?ux con?gurations,gaining insight from the dual M-theory realization.In the latter,the D3-branes correspond to M5-branes along0123610.

3.3.1Mass deformations

The M-theory con?gurations we are considering have an interesting application.Con-?gurations of M5-branes(reducing to NS5-and D4-branes in IIA)have been considered in[22]to study the dynamics of the N=24d supersymmetric gauge theories on the non-compact part of their world-volume.In particular,the situation with one M5-brane along012345and N M5-branes along0123610leads to an N=2U(N)gauge theory with an adjoint hypermultiplet(that is,N=4super-Yang-Mills).

An interesting deformation of this theory corresponds to the introduction of a com-plex mass parameter for the hypermultiplet.In the brane realization,it was argued in [22]to correspond to embedding the M5-brane con?guration in a non-trivial geometry

脐带干细胞综述

脐带间充质干细胞的研究进展 间充质干细胞(mesenchymal stem cells,MSC S )是来源于发育早期中胚层 的一类多能干细胞[1-5],MSC S 由于它的自我更新和多项分化潜能,而具有巨大的 治疗价值 ,日益受到关注。MSC S 有以下特点:(1)多向分化潜能,在适当的诱导条件下可分化为肌细胞[2]、成骨细胞[3、4]、脂肪细胞、神经细胞[9]、肝细胞[6]、心肌细胞[10]和表皮细胞[11, 12];(2)通过分泌可溶性因子和转分化促进创面愈合;(3) 免疫调控功能,骨髓源(bone marrow )MSC S 表达MHC-I类分子,不表达MHC-II 类分子,不表达CD80、CD86、CD40等协同刺激分子,体外抑制混合淋巴细胞反应,体内诱导免疫耐受[11, 15],在预防和治疗移植物抗宿主病、诱导器官移植免疫耐受等领域有较好的应用前景;(4)连续传代培养和冷冻保存后仍具有多向分化潜能,可作为理想的种子细胞用于组织工程和细胞替代治疗。1974年Friedenstein [16] 首先证明了骨髓中存在MSC S ,以后的研究证明MSC S 不仅存在于骨髓中,也存在 于其他一些组织与器官的间质中:如外周血[17],脐血[5],松质骨[1, 18],脂肪组织[1],滑膜[18]和脐带。在所有这些来源中,脐血(umbilical cord blood)和脐带(umbilical cord)是MSC S 最理想的来源,因为它们可以通过非侵入性手段容易获 得,并且病毒污染的风险低,还可冷冻保存后行自体移植。然而,脐血MSC的培养成功率不高[19, 23-24],Shetty 的研究认为只有6%,而脐带MSC的培养成功率可 达100%[25]。另外从脐血中分离MSC S ,就浪费了其中的造血干/祖细胞(hematopoietic stem cells/hematopoietic progenitor cells,HSCs/HPCs) [26, 27],因此,脐带MSC S (umbilical cord mesenchymal stem cells, UC-MSC S )就成 为重要来源。 一.概述 人脐带约40 g, 它的长度约60–65 cm, 足月脐带的平均直径约1.5 cm[28, 29]。脐带被覆着鳞状上皮,叫脐带上皮,是单层或复层结构,这层上皮由羊膜延续过来[30, 31]。脐带的内部是两根动脉和一根静脉,血管之间是粘液样的结缔组织,叫做沃顿胶质,充当血管外膜的功能。脐带中无毛细血管和淋巴系统。沃顿胶质的网状系统是糖蛋白微纤维和胶原纤维。沃顿胶质中最多的葡萄糖胺聚糖是透明质酸,它是包绕在成纤维样细胞和胶原纤维周围的并维持脐带形状的水合凝胶,使脐带免受挤压。沃顿胶质的基质细胞是成纤维样细胞[32],这种中间丝蛋白表达于间充质来源的细胞如成纤维细胞的,而不表达于平滑肌细胞。共表达波形蛋白和索蛋白提示这些细胞本质上肌纤维母细胞。 脐带基质细胞也是一种具有多能干细胞特点的细胞,具有多项分化潜能,其 形态和生物学特点与骨髓源性MSC S 相似[5, 20, 21, 38, 46],但脐带MSC S 更原始,是介 于成体干细胞和胚胎干细胞之间的一种干细胞,表达Oct-4, Sox-2和Nanog等多

二、分析天平的基本操作

模块二滴定分析基本操作任务一分析天平的基本操作 一、分析天平的分类 分析天平是定量分析中最常用的准确称量物质的仪器。分析天平分类:等臂(双盘)分析天平、不等臂(单盘)分析天平、电子天平。 二、电子天平的介绍 1、工作原理:电磁平衡原理,秤盘通过支架连杆支架作用于线圈上,重力方向向下。线圈内有电流通过时,根据电磁基本理论,通电的导线在磁场中将产生一个向上作用的电磁力,与秤盘重力方向相反大小相同,与之相平衡,而通过导线的电流与被称物体的质量成正比。 2、性能特点:a.使用寿命长,性能稳定,灵敏度高,体积小,操作方便 b.称 量速度快、精度高 c.具有自动校准、累计称量、超载显示、自动去皮等功能 3、称量的一般程序 水平调节——打扫——预热——开启显示器——校准——称量——结束工作 ①水平调节检查水平仪,调节水平调节脚,使水泡位于水平仪中心。 ②打扫打扫天平秤盘 ③预热通电预热30min以上 ④开启显示器按ON键,显示器亮,显示屏出现0.0000g ⑤校准按“校准”键 ⑥称量被称物置于秤盘中间进行称量 ⑦称量结束工作取下被称物,核对零点,关闭天平,进行使用登记 4、基本称量方法 ①直接称量法将称量物直接放在天平盘上直接称量物体的质量。例如,称量 小烧杯的质量,容量器皿校正中称量某容量瓶的质量,重量分析实验中称量某坩埚的质量等,都使用这种称量法。 ②固定质量称量法

用于称量某一固定质量的试剂(如基准物质)或试样。适于称量不易吸潮、在空气中能稳定存在的粉末状或小颗粒样品。 A、去皮将干燥的容器置于秤盘上,待显示平衡后按“去皮”键扣除皮重并显示零点 B、加样打开天平门,用药匙将试样抖入容器内,使之达到所需质量。 固定质量称量法注意:若不慎加入试剂超过指定质量,用牛角匙取出多余试剂,直至试剂质量符合指定要求为止。严格要求时,取出的多余试剂应弃去,不要放回原试剂瓶中。操作时不能将试剂散落于天平盘等容器以外的地方,称好的试剂必须定量地由表面皿等容器直接转入接受容器,此即所谓“定量转移”。 ③递减称量法(减量法) 用于称量一定质量范围的样品或试剂。样品易吸水、易氧化或易与二氧化碳等反应时,可选择此法。。 称量步骤:试样的保存——取出盛试样的称量瓶——称出称量瓶质量——敲样——再称出其质量——样品质量——连续称样——称量工作结束 A、试样保存待称样品放于洁净的干燥容器(称量瓶)中,置于干燥器中保存 B、取出称量瓶左手戴手套取出称量瓶或者用折叠成约1cm的纸取出 C、称出称量瓶质量称出称量瓶质量,记录数据 D、敲样将称量瓶取出,在接收容器的上方倾斜瓶身,用称量瓶盖轻敲瓶口上部使试样慢慢落入容器中,瓶盖始终不要离开接受器上方。当倾出的试样接近所需量时,一边继续用瓶盖轻敲瓶口,一边逐渐将瓶身竖直,使粘附在瓶口上的试样落回称量瓶,然后盖好瓶盖,准确称其质量。两次质量之差,即为试样的质量。按上述方法连续递减,可称量多份试样。

外阴白色病变考试试题

外阴白色病变考试试题 一、A1型题(本大题11小题.每题1.0分,共11.0分。每一道考试题下面有A、 B、C、D、E五个备选答案。请从中选择一个最佳答案,并在答题卡上将相应题号的相应字母所属的方框涂黑。) 第1题 外阴硬化性苔癣的早期病理改变是 A 表层细胞过度角化 B 表层细胞增生 C 真皮乳头层水肿 D 毛囊角质栓塞 E 底层细胞增生 【正确答案】:C 【本题分数】:1.0分 第2题 女,50岁。因外阴瘙痒而就医,组织病理为增生型,营养不良,下列治疗中哪项是正确的 A 因有恶变趋向,应及早手术治疗 B 全身治疗 C 补充多量维生素 D 活检有非典型增生时手术治疗 E 全身+局部治疗 【正确答案】:D 【本题分数】:1.0分 第3题 关于外阴瘙痒下列哪项是正确的 A 外阴瘙痒是外阴癌的早期表现 B 外阴瘙痒最常见的原因是蛲虫病

C 外阴瘙痒严重时用肥皂液清洗会有所好转 D 外阴瘙痒经治疗无效应作单纯性外阴切除术 E 外阴瘙痒不是一种疾病而是多种疾病可引起的一种症状 【正确答案】:E 【本题分数】:1.0分 第4题 女,37岁。外阴奇痒,分泌物不多。妇检:两侧小阴唇增厚,外阴粘膜不红,阴道畅,皱襞正常,无异常分泌物,宫颈柱状,光滑,I°肥大,子宫前位,常大,双附件(-),为确诊应选用 A 外阴活检 B 阴道分泌物涂片 C 宫颈涂片(CG D 阴道镜 E 盆腔B超 【正确答案】:A 【本题分数】:1.0分 第5题 属于癌前病变的外阴白色病变是 A 增生型营养不良 B 硬化苔癣型营养不良 C 混合型营养不良 D 营养不良伴有上皮不典型增生 E 白癜风 【正确答案】:D 【本题分数】:1.0分 第6题

精神分裂症的病因及发病机理

精神分裂症的病因及发病机理 精神分裂症病因:尚未明,近百年来的研究结果也仅发现一些可能的致病因素。(一)生物学因素1.遗传遗传因素是精神分裂症最可能的一种素质因素。国内家系调查资料表明:精神分裂症患者亲属中的患病率比一般居民高6.2倍,血缘关系愈近,患病率也愈高。双生子研究表明:遗传信息几乎相同的单卵双生子的同病率远较遗传信息不完全相同 的双卵双生子为高,综合近年来11项研究资料:单卵双生子同病率(56.7%),是双卵双生子同病率(12.7%)的4.5倍,是一般人口患难与共病率的35-60倍。说明遗传因素在本病发生中具有重要作用,寄养子研究也证明遗传因素是本症发病的主要因素,而环境因素的重要性较小。以往的研究证明疾病并不按类型进行遗传,目前认为多基因遗传方式的可能性最大,也有人认为是常染色体单基因遗传或多源性遗传。Shields发现病情愈轻,病因愈复杂,愈属多源性遗传。高发家系的前瞻性研究与分子遗传的研究相结合,可能阐明一些问题。国内有报道用人类原癌基因Ha-ras-1为探针,对精神病患者基因组进行限止性片段长度多态性的分析,结果提示11号染色体上可能存在着精神分裂症与双相情感性精神病有关的DNA序列。2.性格特征:约40%患者的病前性格具有孤僻、冷淡、敏感、多疑、富于幻想等特征,即内向

型性格。3.其它:精神分裂症发病与年龄有一定关系,多发生于青壮年,约1/2患者于20~30岁发病。发病年龄与临床类型有关,偏执型发病较晚,有资料提示偏执型平均发病年龄为35岁,其它型为23岁。80年代国内12地区调查资料:女性总患病率(7.07%。)与时点患病率(5.91%。)明显高于男性(4.33%。与3.68%。)。Kretschmer在描述性格与精神分裂症关系时指出:61%患者为瘦长型和运动家型,12.8%为肥胖型,11.3%发育不良型。在躯体疾病或分娩之后发生精神分裂症是很常见的现象,可能是心理性生理性应激的非特异性影响。部分患者在脑外伤后或感染性疾病后发病;有报告在精神分裂症患者的脑脊液中发现病毒性物质;月经期内病情加重等躯体因素都可能是诱发因素,但在精神分裂症发病机理中的价值有待进一步证实。(二)心理社会因素1.环境因素①家庭中父母的性格,言行、举止和教育方式(如放纵、溺爱、过严)等都会影响子女的心身健康或导致个性偏离常态。②家庭成员间的关系及其精神交流的紊乱。③生活不安定、居住拥挤、职业不固定、人际关系不良、噪音干扰、环境污染等均对发病有一定作用。农村精神分裂症发病率明显低于城市。2.心理因素一般认为生活事件可发诱发精神分裂症。诸如失学、失恋、学习紧张、家庭纠纷、夫妻不和、意处事故等均对发病有一定影响,但这些事件的性质均无特殊性。因此,心理因素也仅属诱发因

外阴疾病

外阴疾病 外阴:阴道口外边的外露部分肛门、阴道口及尿道邻近,经常受阴道分泌物及尿液的浸渍,容易发炎。 常见病症:外因瘙痒、外阴炎、外阴白色病变、外因溃疡、外阴癌 外阴疾病 外阴:阴道口外边的外露部分肛门、阴道口及尿道邻近,经常受阴道分泌物及尿液的浸渍,容易发炎。 常见病症:外因瘙痒、外阴炎、外阴白色病变、外因溃疡、外阴癌 外因瘙痒 外阴瘙痒是妇科疾病中很常见的一种症状,外阴是特别敏感的部位,妇科多种病变及外来刺激均可引起瘙痒,使人寝食难安、坐卧不宁。外阴瘙痒多发生于阴蒂、小阴唇,也可波及大阴唇、会阴和肛周 病因:1.慢性局部刺激,外阴、阴道、宫颈炎症的异常分泌物的刺激; 2.外阴不清洁及紧身化纤内裤、卫生巾等致通透不良; 3.外阴寄生虫病,如阴虱、蛲虫、疥疮等; 4.各种外阴皮肤病和外阴肿瘤等; 5.全身性疾病的外阴局部症状,如糖尿病、尿毒症、维生素缺乏等。 症状:外因皮肤瘙痒、烧灼感和疼痛瘙痒部位多生与阴帝、小阴唇、也可波及大阴、会阴、甚至肛周围 危害:(1)性外阴部瘙痒严重时,不但使人坐卧不宁,影响工作、学习、生活和睡眠。 (2)由于女性外阴瘙痒,会影响夫妻生活,所以极有导致夫妻感情不和,严重的 甚至造成感情破裂,婚姻走向终点。 (3)诱发生殖器感染,盆腔炎、肾周炎、性交痛等,日久不愈还可导致多种疾病 同时发生,疾病的危害严重的会危害女性健康,甚至还会造成女性不孕等严重后果。 (4)女性外阴瘙痒严重时,不易根治,易反复,引发早产、胎儿感染畸形等,造 成终身遗憾。 治疗1.外阴涂药

使用有止痒作用的洗剂、膏霜等,如炉甘石洗剂、苯海拉明软膏、皮质醇类软膏等。 2.局部封闭或穴位注药 如皮质醇激素、维生素B12、非那根等。 3.针对病因治疗。 4.预防1. 注意经期卫生,勤清洗。 2.不要冲洗阴道,因为阴道有自清的功能,如果刻意冲洗反而不利 3.忌乱用、烂用药物,忌抓搔及局部摩擦。 4.忌酒及辛辣食物,不吃海鲜等及易引起过敏的药物 6 .久治不愈者应作血糖检查。少吃糖类可避免常常感染霉菌,如少吃淀粉类、糖类以及刺激性的食物(例如酒、辛辣物、油炸类),多吃蔬菜水果类,水份要充足。 5、不穿紧身兜裆裤,内裤更须宽松、透气,并以棉制品为宜。 6.就医检查是否有霉菌或滴虫,如有应及时治疗,而不要自己应用“止痒水”治疗。 8.保持外阴清洁干燥,尤其在经期、孕期、产褥期,每天用女性护理液清洗外阴更换内裤。 9.不穿化纤内裤、紧身裤,着棉织内衣裤。局部坐浴时注意溶液浓度、温度及时间、注意事项。 10.外阴瘙痒者应勤剪指甲、勤洗手,不要搔抓皮肤,以防破溃感染从而继发细菌性感染。 11.上完厕所请记得由前往后擦,因为肛门可能会带来不少细菌,所以如厕后请不要由肛门擦到阴部,才能减少感染的机会。 12.内裤要和其他的衣物分开洗,最好暴晒,可以减少细菌的滋生。如果患有霉菌性阴道炎的话,最好内裤都有热水煮 外阴溃疡外阴溃疡是发生于外阴部的皮肤黏膜发炎、溃烂、缺损。病灶多发生于小阴唇和大阴唇内侧,其次为前庭黏膜及阴道口周围。病程有急性及慢性。 大小阴唇、阴道口周围、阴蒂等处(外阴疾病发展中出现的一个过程,不是一个独立的疾病,有急性和慢性)急性外阴溃疡:非特异性外阴炎病情较轻,多在搔抓之后出现一般比较表浅,但疼痛比较厉害 慢性外阴溃疡:持续时间较长,或者反复发作 癌症引起的溃疡,与结核性溃疡很难鉴别,需做确诊

脐带血造血干细胞库管理办法(试行)

脐带血造血干细胞库管理办法(试行) 第一章总则 第一条为合理利用我国脐带血造血干细胞资源,促进脐带血造血干细胞移植高新技术的发展,确保脐带血 造血干细胞应用的安全性和有效性,特制定本管理办法。 第二条脐带血造血干细胞库是指以人体造血干细胞移植为目的,具有采集、处理、保存和提供造血干细胞 的能力,并具有相当研究实力的特殊血站。 任何单位和个人不得以营利为目的进行脐带血采供活动。 第三条本办法所指脐带血为与孕妇和新生儿血容量和血循环无关的,由新生儿脐带扎断后的远端所采集的 胎盘血。 第四条对脐带血造血干细胞库实行全国统一规划,统一布局,统一标准,统一规范和统一管理制度。 第二章设置审批 第五条国务院卫生行政部门根据我国人口分布、卫生资源、临床造血干细胞移植需要等实际情况,制订我 国脐带血造血干细胞库设置的总体布局和发展规划。 第六条脐带血造血干细胞库的设置必须经国务院卫生行政部门批准。 第七条国务院卫生行政部门成立由有关方面专家组成的脐带血造血干细胞库专家委员会(以下简称专家委

员会),负责对脐带血造血干细胞库设置的申请、验收和考评提出论证意见。专家委员会负责制订脐带血 造血干细胞库建设、操作、运行等技术标准。 第八条脐带血造血干细胞库设置的申请者除符合国家规划和布局要求,具备设置一般血站基本条件之外, 还需具备下列条件: (一)具有基本的血液学研究基础和造血干细胞研究能力; (二)具有符合储存不低于1 万份脐带血的高清洁度的空间和冷冻设备的设计规划; (三)具有血细胞生物学、HLA 配型、相关病原体检测、遗传学和冷冻生物学、专供脐带血处理等符合GMP、 GLP 标准的实验室、资料保存室; (四)具有流式细胞仪、程控冷冻仪、PCR 仪和细胞冷冻及相关检测及计算机网络管理等仪器设备; (五)具有独立开展实验血液学、免疫学、造血细胞培养、检测、HLA 配型、病原体检测、冷冻生物学、 管理、质量控制和监测、仪器操作、资料保管和共享等方面的技术、管理和服务人员; (六)具有安全可靠的脐带血来源保证; (七)具备多渠道筹集建设资金运转经费的能力。 第九条设置脐带血造血干细胞库应向所在地省级卫生行政部门提交设置可行性研究报告,内容包括:

电子天平使用说明书.

电子天平使用说明书 使用方法 ◎准备 1、将天平安放在稳定及水平的工作台上,避免振动、气流、阳光直射和剧烈的温度波动; 2、安装称盘; 3、接通电源前请确认当地交流电压是否与天平所附的电源适配器所需电压一致; 4、为获得准确的称量结果,在进行称量前天平应接通电源预热30分钟。 ◎电源 1. 天平随机附配交流电源适配器,输入220+22-33V ~ 50Hz 输出9V 300mA 2. 天平选用电池供电时可打开天平底部的电池盖按极性指示装入电池即可,建议使用9伏碱性电池,可连续工作约12小时。 当天平电池供电时,显示屏左上角电量指示框显示段数表明电池的状态(显示3段:电池充足,显示0段:电池耗尽,当电池电量将耗尽时,最后一个显示段闪烁。 ◎开机 在称盘空载情况下按<开/关>键,天平依次进入自检显示(显示屏所有字段短时点亮、型号显示和零状态显示,当天平显示零状态时即可进行称量; 当遇到相关功能键设置有误无法恢复时,按<开/关>键重新开机即可恢复初始设置状态。

◎校准 为获得准确的称量结果,必须对天平进行校准以适应当地的重力加速度。校准应在天平预热结束后进行,遇到以下情况必须使用外部校准砝码对天平进行校准。 1. 首次使用天平称量之前; 2. 天平改变安放位置后。 校准方法与步骤: 1.准备好校准用的标准砝码并确保称盘空载; 2.按<去皮>键:天平显示零状态; 3.按<校准>键:天平显示闪烁的CAL—XXX,(XXX一般为100、200或其它数字,提醒使用相对应的100g、200g或其它规格的标准砝码 4.将标准砝码放到称盘中心位置,天平显示CAL-XXX,等待几秒钟后,显示标准砝码的量值。此时移去砝码,天平显示零状态,则表示校准结束,可以进行称量。如天平不零状态,应重复进行一次校准工作。 ◎称量 天平经校准后即可进行称量,称量时必须等显示器左下角的“○”标志熄灭后才可读数,称量过程中被称物必须轻拿轻放,并确保不使天平超载,以免损坏天平的传感器。 ◎清零或去皮 清零:当天平空载时,如显示不在零状态,可按<去皮>键,使天平显示零状态。此时才可进行正常称量。

分析天平使用说明书

TG-328分析天平使用说明书 一、分析天平结构及作用原理: 1.该分析天平,是属于双盘等臂式,横梁采用铜镍合金制成,上面装有玛瑙刀三把,中间为固定的支点刀,两边可调整的承重刀。 好仪器,好资料,尽在沧州建仪(https://www.360docs.net/doc/f415349345.html,)。欢迎查询。 打造中国建仪销售第一品牌,树立沧州产品全新形象 2.支点刀位于支点刀垫上,支点刀垫固定在天平立柱上端。 3.横梁停动装置为双层折翼式,在天平开启时,横梁上的承重刀必须比支点刀先接角触,为了避免刀锋损坏和保证横梁位置的再现性,开启天平求轻稳,避免冲击,摇晃。 4.横梁的左右两端悬挂承重挂钩,左承重挂钩上装有砝码承重架,该二零碎件分别挂在小刀刃上,另有秤盘各一件分别挂在承重挂钩上。 5.整个天平固定在大理石的基座板上,底板前下部装有二只可供调整水平位置的螺旋脚,后面装有一只固定脚,天平木框前面有一扇可供启闭及随意停止在上下位置的玻璃门,右侧有一扇玻璃移门。 6.秤盘上节中间的阻尼装置,是用铝合金板制成,固定在中柱上。是利用空气阻力来减少横梁的摆动时间,达到静止迅速,从而提高工作效率。

7.光学报影装置,固定在底板上前方,可直接读出0.1-10毫克以内的重量值。 8.天平外框左侧装有机械加码装置,通过三档增减砝码的指示旋钮来变换自10毫克-199.99克砝码以内所需重量值。 二、分析天平主要技术指标: 规格型号技术参数:秤盘尺寸 TG328A200g/0.1mg80mm TG328B200g/0.1mg80mm1 TG628A200g/1mg80mm 三、分析天平性能特点: 1.TG系列双盘机械天平,采用空气阻尼,光电读数,具有称量准确,读数简便,价格实惠。 2.专供实验室,学校,工矿等作精密称量分析用。 四、天平的安装方法: a.安装前的准备工作安装前的准备工作安装前的准备工作安装前的准备工作 1.安装选择:天平必须放在牢固的台上,不准有震动,气流存在,室内气温要求干燥明亮,温度最好保持在20℃±2℃左右,避免阳光晒射单面受热和气温潮湿,反之影响天平的灵敏度和正确性。

外阴白色病变的症状表现有哪些

外阴白色病变的症状表现有哪些 外阴白色病变是慢性外阴的营养不良。属于营养不良的一种。而这也有分为好几个类型,混合型、增生型和硬化苔藓型等等都是外阴白色病变的类型。 外阴奇痒为主要症状,搔痒时间从发病到治疗有2~3月之内,也有达20 年之久,搔痒剧烈程度不分季节与昼夜,如伴有滴虫性或霉菌性阴道炎,分泌物会更多,局部烧灼感,刺痛与搔痒所致的皮肤粘膜破损或感染有关,局部有不同程度的皮肤粘膜色素减退,常有水肿,皲裂及散在的表浅溃疡。 一、增生型营养不良 一般发生在30~60岁的妇女,主要症状为外阴奇痒难忍,抓伤后疼痛加剧,病变范围不一,主要波及大阴唇,阴唇间沟,阴蒂包皮和后联合处,多呈对称性,病变皮肤增厚似皮革,隆起有皱襞,或有鳞屑,湿疹样改变,表面颜色多暗红或粉红,夹杂有界限清晰的白色斑块,一般无萎缩或粘连。 二、硬化苔藓型营养不良 可见于任何年龄,多见于40岁左右妇女,主要症状为病变区发痒,但一般远较增生型病变为轻,晚期出现性交困难,病变累及外阴皮肤,粘膜和肛周围皮肤,除皮肤或粘膜变白,变薄,干燥易皲裂外,并失去弹性,阴蒂多萎缩,且与包皮粘连,小阴唇平坦消失,晚期皮肤菲薄皱缩似卷烟纸,阴道口挛缩狭窄,仅容指尖。 幼女患此病多在小便或大便后感外阴及肛周不适,外阴及肛周区出现锁孔状珠黄色花斑样或白色病损,一般至青春期时,病变多自行消失。 三、混合型营养不良 主要表现为菲薄的外阴发白区的邻近部位,或在其范围内伴有局灶性皮肤增厚或隆起。 四、增生型或混合型伴上皮非典型增生 一般认为在增生型及混合型病变中,仅5、10例可出现非典型增生,且此非典型增生仅限于增生的上皮细胞部分。非典型增生多无特殊临床表现,局部组织活体组织检查为唯一的诊断方法。但如外阴局部出现溃疡。或界限清楚的白色隆起时,在该处活检发现非典型增生,其癌变的可能性较大。

精神分裂症的发病原因是什么

精神分裂症的发病原因是什么 精神分裂症是一种精神病,对于我们的影响是很大的,如果不幸患上就要及时做好治疗,不然后果会很严重,无法进行正常的工作和生活,是一件很尴尬的事情。因此为了避免患上这样的疾病,我们就要做好预防,今天我们就请广州协佳的专家张可斌来介绍一下精神分裂症的发病原因。 精神分裂症是严重影响人们身体健康的一种疾病,这种疾病会让我们整体看起来不正常,会出现胡言乱语的情况,甚至还会出现幻想幻听,可见精神分裂症这种病的危害程度。 (1)精神刺激:人的心理与社会因素密切相关,个人与社会环境不相适应,就产生了精神刺激,精神刺激导致大脑功能紊乱,出现精神障碍。不管是令人愉快的良性刺激,还是使人痛苦的恶性刺激,超过一定的限度都会对人的心理造成影响。 (2)遗传因素:精神病中如精神分裂症、情感性精神障碍,家族中精神病的患病率明显高于一般普通人群,而且血缘关系愈近,发病机会愈高。此外,精神发育迟滞、癫痫性精神障碍的遗传性在发病因素中也占相当的比重。这也是精神病的病因之一。 (3)自身:在同样的环境中,承受同样的精神刺激,那些心理素质差、对精神刺激耐受力低的人易发病。通常情况下,性格内向、心胸狭窄、过分自尊的人,不与人交往、孤僻懒散的人受挫折后容易出现精神异常。 (4)躯体因素:感染、中毒、颅脑外伤、肿瘤、内分泌、代谢及营养障碍等均可导致精神障碍,。但应注意,精神障碍伴有的躯体因素,并不完全与精神症状直接相关,有些是由躯体因素直接引起的,有些则是以躯体因素只作为一种诱因而存在。 孕期感染。如果在怀孕期间,孕妇感染了某种病毒,病毒也传染给了胎儿的话,那么,胎儿出生长大后患上精神分裂症的可能性是极其的大。所以怀孕中的女性朋友要注意卫生,尽量不要接触病毒源。 上述就是关于精神分裂症的发病原因,想必大家都已经知道了吧。患上精神分裂症之后,大家也不必过于伤心,现在我国的医疗水平是足以让大家快速恢复过来的,所以说一定要保持良好的情绪。

电子精密天平秤的使用方法及注意事项(正式版)

电子精密天平秤的使用方法及注意事项 刘维彬电子精密天平秤是定量分析工作中不可缺少的重要仪器,充分了解仪器性能及熟练掌握其使用方法,是获得可靠分析结果的保证。精密天平的种类很多,有普通精密天平、半自动/全自动加码电光投影阻尼精密天平及电子精密天平等。下面就电子精密天平的使用方法及注意事项做一介绍。 操作方法: 1.检查并调整天平至水平位置。 2.事先检查电源电压是否匹配(必要时配置稳压器),按仪器要求通电预热至所需时间。 3.预热足够时间后打开天平开关,天平则自动进行灵敏度及零点调节。待稳定标志显示后,可进行正式称量。 4.称量时将洁净称量瓶或称量纸置于称盘上,关上侧门,轻按一下去皮键,天平将自动校对零点,然后逐渐加入待称物质,直到所需重量为止。 5.称量结束应及时除去称量瓶(纸),关上侧门,切断电源,并做好使用情况登记。 注意事项: 1.天平应放置在牢固平稳水泥台或木台上,室内要求清洁、干燥及较恒定的温度,同时应避免光线直接照射到天平上。 2.称量时应从侧门取放物质,读数时应关闭箱门以免空气流动引起天平摆动。前门仅在检修或清除残留物质时使用。 3.电子精密天平若长时间不使用,则应定时通电预热,每周一次,每次预热

2h,以确保仪器始终处于良好使用状态。 4.天平箱内应放置吸潮剂(如硅胶),当吸潮剂吸水变色,应立即高温烘烤更换,以确保吸湿性能。 5.挥发性、腐蚀性、强酸强碱类物质应盛于带盖称量瓶内称量,防止腐蚀天平。 6.称量重量不得过天平的最大载荷。 7.经常对电子天平进行自校或定期外校,保证其处于最佳状态。 8.天平发生故障,不得擅自修理,应立即报告测试中心质量负责人。 9.天平放妥后不宜经常搬动。必须搬动时,移动天平位置后,应由市计量部门校正计量合格后,方可使用。

外阴白色病变的检查诊断方法是什么

外阴白色病变的检查诊断方法是什么 外阴奇痒是外阴白色病变的主要症状,搔痒时间从发病到治疗有2~3月之内,也有达20年之久,搔痒剧烈程度不分季节与昼夜。专家提示,一旦发现自己有类似于外阴白色病变的这种,应立即到医院进行确诊。早期的诊断及治疗对我们早日恢复健康并且尤为重要。 外阴白色病变的检查: 多点活检送病理检查,确定病变性质,排除早期癌变,活检应在有皲裂,溃疡,隆起,硬结或粗糙处进行,为做到取材适当,可先用1%甲苯胺蓝(toluidine blue)涂病变区,待白干后,再用1%醋酸液擦洗脱色,凡不脱色区表示该处有裸核存在,提示在该处活检,发现非典型增生或甚至癌变的可能性较大,如局部破损区太广,应先治疗数日,待皮损大部愈合后,再选择活检部位以提高诊断准确率。 外阴白色病变的诊断: 1、症状判断:外阴白斑一般根据症状就可以判断,比如,外阴局部粘 膜发白,瘙痒、粗糙、脱屑等现象的出现,都会诊断为外阴白斑,当然,外阴白斑有很多的类型,如果外阴白斑属于增生型,也就是说局部的皮肤粘膜增厚了,弹性变差了,而且也出现了相应的溃疡等不适症状。这是主要的外阴白斑的诊断方法。 2、细胞活检:有时外阴白斑的诊断需要进一步的做细胞活检,观察有 没有癌细胞,以便于确诊。活检病理检查确定病变性质,排除早期癌变。活检应在有皲裂溃疡、隆起、硬结或粗糙处进行为做到取材适当,外阴白斑的诊断方法可先用1%甲苯胺蓝涂病变区,待白干后再用1%醋酸液擦洗脱色。凡不脱色区表示该处有裸核存在,提示在该处活检发现非典型增生或甚至癌变的可能性较大。如局部破损区太广,应先治疗数日待皮损大部愈合后,再选择活检部位以提高诊断准确率。 3、病理诊断依据:除了解疾病的主要临床症状外,还应对疾病的发病 机理有一定的认识,因为导致外阴白斑皮肤瘙痒及色素的减退或脱色的疾病有很多种,不只是外阴白斑一种,它们的表现虽有些不同,但用肉眼不易区别开来,所以当遇到外阴有病损不典型或慢性皲裂、局限性增厚、溃破等症状的患者时,必须依靠活组织病理检查确诊。

精神分裂症的病因是什么

精神分裂症的病因是什么 精神分裂症是一种精神方面的疾病,青壮年发生的概率高,一般 在16~40岁间,没有正常器官的疾病出现,为一种功能性精神病。 精神分裂症大部分的患者是由于在日常的生活和工作当中受到的压力 过大,而患者没有一个良好的疏导的方式所导致。患者在出现该情况 不仅影响本人的正常社会生活,且对家庭和社会也造成很严重的影响。 精神分裂症常见的致病因素: 1、环境因素:工作环境比如经济水平低低收入人群、无职业的人群中,精神分裂症的患病率明显高于经济水平高的职业人群的患病率。还有实际的生活环境生活中的不如意不开心也会诱发该病。 2、心理因素:生活工作中的不开心不满意,导致情绪上的失控,心里长期受到压抑没有办法和没有正确的途径去发泄,如恋爱失败, 婚姻破裂,学习、工作中不愉快都会成为本病的原因。 3、遗传因素:家族中长辈或者亲属中曾经有过这样的病人,后代会出现精神分裂症的机会比正常人要高。 4、精神影响:人的心里与社会要各个方面都有着不可缺少的联系,对社会环境不适应,自己无法融入到社会中去,自己与社会环境不相

适应,精神和心情就会受到一定的影响,大脑控制着人的精神世界, 有可能促发精神分裂症。 5、身体方面:细菌感染、出现中毒情况、大脑外伤、肿瘤、身体的代谢及营养不良等均可能导致使精神分裂症,身体受到外界环境的 影响受到一定程度的伤害,心里受到打击,无法承受伤害造成的痛苦,可能会出现精神的问题。 对于精神分裂症一定要配合治疗,接受全面正确的治疗,最好的 疗法就是中医疗法加心理疗法。早发现并及时治疗并且科学合理的治疗,不要相信迷信,要去正规的医院接受合理的治疗,接受正确的治 疗按照医生的要求对症下药,配合医生和家人,给病人创造一个良好 的治疗环境,对于该病的康复和痊愈会起到意想不到的效果。

卫生部办公厅关于印发《脐带血造血干细胞治疗技术管理规范(试行)

卫生部办公厅关于印发《脐带血造血干细胞治疗技术管理规 范(试行)》的通知 【法规类别】采供血机构和血液管理 【发文字号】卫办医政发[2009]189号 【失效依据】国家卫生计生委办公厅关于印发造血干细胞移植技术管理规范(2017年版)等15个“限制临床应用”医疗技术管理规范和质量控制指标的通知 【发布部门】卫生部(已撤销) 【发布日期】2009.11.13 【实施日期】2009.11.13 【时效性】失效 【效力级别】部门规范性文件 卫生部办公厅关于印发《脐带血造血干细胞治疗技术管理规范(试行)》的通知 (卫办医政发〔2009〕189号) 各省、自治区、直辖市卫生厅局,新疆生产建设兵团卫生局: 为贯彻落实《医疗技术临床应用管理办法》,做好脐带血造血干细胞治疗技术审核和临床应用管理,保障医疗质量和医疗安全,我部组织制定了《脐带血造血干细胞治疗技术管理规范(试行)》。现印发给你们,请遵照执行。 二〇〇九年十一月十三日

脐带血造血干细胞 治疗技术管理规范(试行) 为规范脐带血造血干细胞治疗技术的临床应用,保证医疗质量和医疗安全,制定本规范。本规范为技术审核机构对医疗机构申请临床应用脐带血造血干细胞治疗技术进行技术审核的依据,是医疗机构及其医师开展脐带血造血干细胞治疗技术的最低要求。 本治疗技术管理规范适用于脐带血造血干细胞移植技术。 一、医疗机构基本要求 (一)开展脐带血造血干细胞治疗技术的医疗机构应当与其功能、任务相适应,有合法脐带血造血干细胞来源。 (二)三级综合医院、血液病医院或儿童医院,具有卫生行政部门核准登记的血液内科或儿科专业诊疗科目。 1.三级综合医院血液内科开展成人脐带血造血干细胞治疗技术的,还应当具备以下条件: (1)近3年内独立开展脐带血造血干细胞和(或)同种异基因造血干细胞移植15例以上。 (2)有4张床位以上的百级层流病房,配备病人呼叫系统、心电监护仪、电动吸引器、供氧设施。 (3)开展儿童脐带血造血干细胞治疗技术的,还应至少有1名具有副主任医师以上专业技术职务任职资格的儿科医师。 2.三级综合医院儿科开展儿童脐带血造血干细胞治疗技术的,还应当具备以下条件:

妇科良方_第二章 外阴白色病变及外阴瘙痒症方

外阴白色病变方 外阴白色病变包括由于各种因素影响所致之外阴部皮肤及粘膜的不同程度变白及(或)粗糙、萎缩的状态。1975年国际外阴病研究会改称“外阴白斑”为“慢性外阴营养不良”,并根据其组织病理变化的不同而分为增生型营养不良(包括无非典型增生、非典型增生两类)、硬化苔藓型营养不良、混合型营养不良(亦包括无非典型增生、非典型增生两类)三种类型。 外阴瘙痒为本病主要症状,搔抓可造成局部破溃与感染而出现烧灼感、疼痛、流液。增生型皮肤增厚似皮革,粗糙,或有鳞屑、湿疹样改变,表面颜色多暗红或粉红,夹杂有界限清晰的白色斑块;硬化苔藓型皮肤或粘膜变白变薄,甚至裂开,阴道口萎缩者可致性交痛;混合型是在外阴萎缩的基础上又有增厚的斑块或疣状增生灶。各型均以病检为主要诊断依据。 西医治疗可内服维生素A、B2、B6、鱼甘油等;局部用药以止痒、消炎、润肤和改善局部营养为目的,用药应依据病理类型。如增生型可用肤轻松、氢化可的松等软膏涂擦;硬化苔藓型给予1~2%丙酸睾丸酮鱼甘油软膏;混合型则用丙酸睾素软膏与可的松软膏合用或先后使用。氦氖激光照射对外阴硬萎有一定疗效。 本病一般属中医“阴痒”、“阴蚀”等病证范畴。其发病机理,常因肝肾阴血不足,不能滋养阴器,血虚生风化燥,而致阴部奇痒难忍;或因脾气亏虚,一则气虚血少,不能滋养阴部,脾虚又可生湿,流注于下,形成气血不足而湿浊停滞的虚实夹杂局面;或因湿热内盛,热蕴阴部肌肤而致阴痒阴肿;久病入络,气血运行不畅而成瘀滞,与湿浊相互胶结,而见苔癣、奇痒、干裂诸候,且经久难愈。治疗当结合病因病机,或滋养肝肾,养血熄风止痒;或清热利湿,祛风止痒;或活血化瘀软坚;或健脾祛湿杀虫等。 本节选介消斑膏丸方、蛇桑坐浴方等治疗外阴白色病变验方共13首。 1.消斑膏丸方 【药物组成】①外用消斑膏:A、消斑膏1号:补骨脂、仙灵脾各9g,生狼毒、白藓皮各6g,蛇床子、徐长卿各15g,薄荷1g。用其酒精渗出液,回收浓缩后,制成霜剂;B、消斑膏2号:即1号去薄荷,加0.1%强的松粉拌匀而成(制法同上);C、消斑膏3号:即1号去狼毒、薄荷,加白花蛇舌草、一枝黄花各30g(制法同上);D、消斑膏4号:即1号去薄荷加丙酸睾丸酮做成0.2%的霜剂(制法同上)。 ②内服消斑丸:黄芪、丹参、当归、菟丝子、仙灵脾、白蒺藜各3g,白藓皮4g,木香 0.2g。共研细末,做成蜜丸或煎成汤剂(以上为1日量)。 【治疗方法】①外用消斑膏:1号适用于外阴无破溃或皲裂者;2号适用于对1号有过敏反应但无癌变可能者;3号适用于局部有感染、破溃或皲裂,或有霉菌,滴虫感染者;4号适用于外阴萎缩或有粘连者。 以上软膏均每日外涂阴部1~2次。 ②内服消斑丸:每日2次,每次10g。所有病例均服此丸。 膏剂外用和丸剂内服,均以3个月为1疗程。一般用药1~3个疗程。

精神分裂症应该怎么治疗

精神分裂症应该怎么治疗 1、坚持服药治疗 服药治疗是最有效的预防复发措施临床大量统计资料表明,大多数精神分裂症的复发与自行停药有关。坚持维持量服药的病人复发率为40%。而没坚持维持量服药者复发率高达80%。因此,病人和家属要高度重视维持治疗。 2、及时发现复发的先兆,及时处理 精神分裂症的复发是有先兆的,只要及时发现,及时调整药物和剂量,一般都能防止复发,常见的复发先兆为:病人无原因出现睡眠不好、懒散、不愿起床、发呆发愣、情绪不稳、无故发脾气、烦躁易怒、胡思乱想、说话离谱,或病中的想法又露头等。这时就应该及时就医,调整治疗病情波动时的及时处理可免于疾病的复发。 3、坚持定期门诊复查 一定要坚持定期到门诊复查,使医生连续地、动态地了解病情,使病人经常处于精神科医生的医疗监护之下,及时根据病情变化调整药量。通过复查也可使端正人及时得到咨询和心理治疗解除病人在生活、工作和药物治疗中的各种困惑,这对预防精神分裂症的复发也起着重要作用。 4、减少诱发因素 家属及周围人要充分认识到精神分裂症病人病后精神状态的薄弱性,帮助安排好日常的生活、工作、学习。经常与病人谈心,帮助病人正确对待疾病,正确对待现实生活,帮助病人提高心理承受能力,学会对待应激事件的方法,鼓励病人增强信心,指导病人充实生活,使病人在没有心理压力和精神困扰的环境中生活。 首先是性格上的改变,塬本活泼开朗爱玩的人,突然变得沉默寡言,独自发呆,不与人交往,爱干净的人也变的不注意卫生、生活

懒散、纪律松弛、做事注意力不集中,总是和患病之前的性格完全 相悖。 再者就是语言表达异常,在谈话中说一些无关的谈话内容,使人无法理解。连最简单的话语都无法准确称述,与之谈话完全感觉不 到重心。 第三个就是行为的异常,行为怪异让人无法理解,喜欢独处、不适意的追逐异性,不知廉耻,自语自笑、生活懒散、时常发呆、蒙 头大睡、四处乱跑,夜不归宿等。 还有情感上的变化,失去了以往的热情,开始变的冷淡、对亲人不关心、和友人疏远,对周围事情不感兴趣,一点消失都可大动干戈。 最后就是敏感多疑,对任何事情比较敏感,精神分裂症患者,总认为有人针对自己。甚至有时认为有人要害自己,从而不吃不喝。 但是也有的会出现难以入眠、容易被惊醒或睡眠不深,整晚做恶梦或者长睡不醒的现象。这些都有可能是患上了精神分裂症。 1.加强心理护理 心理护理是家庭护理中的重要方面,由于社会上普遍存在对精神病人的歧视和偏见,给病人造成很大的精神压力,常表现为自卑、 抑郁、绝望等,有的病人会因无法承受压力而自杀。家属应多给予 些爱心和理解,满足其心理需求,尽力消除病人的悲观情绪。病人 生活在家庭中,与亲人朝夕相处,接触密切,家属便于对病人的情感、行为进行细致的观察,病人的思想活动也易于向家属暴露。家 属应掌握适当的心理护理方法,随时对病人进行启发与帮助,启发 病人对病态的认识,帮助他们树立自信,以积极的心态好地回归社会。 2.重视服药的依从性 精神分裂症病人家庭护理的关键就在于要让病人按时按量吃药维持治疗。如果不按时服药,精神病尤其是精神分裂症的复发率很高。精神病人在医院经过一系统的治疗痊愈后,一般需要维持2~3年的

卫生部关于印发《脐带血造血干细胞库设置管理规范(试行)》的通知

卫生部关于印发《脐带血造血干细胞库设置管理规范(试行)》的通知 发文机关:卫生部(已撤销) 发布日期: 2001.01.09 生效日期: 2001.02.01 时效性:现行有效 文号:卫医发(2001)10号 各省、自治区、直辖市卫生厅局: 为贯彻实施《脐带血造血干细胞库管理办法(试行)》,保证脐带血临床使用的安全、有效,我部制定了《脐带血造血干细胞库设计管理规范(试行)》。现印发给你们,请遵照执行。 附件:《脐带血造血干细胞库设置管理规范(试行)》 二○○一年一月九日 附件: 脐带血造血干细胞库设置管理规范(试行) 脐带血造血干细胞库的设置管理必须符合本规范的规定。 一、机构设置 (一)脐带血造血干细胞库(以下简称脐带血库)实行主任负责制。 (二)部门设置 脐带血库设置业务科室至少应涵盖以下功能:脐带血采运、处理、细胞培养、组织配型、微生物、深低温冻存及融化、脐带血档案资料及独立的质量管理部分。 二、人员要求

(一)脐带血库主任应具有医学高级职称。脐带血库可设副主任,应具有临床医学或生物学中、高级职称。 (二)各部门负责人员要求 1.负责脐带血采运的人员应具有医学中专以上学历,2年以上医护工作经验,经专业培训并考核合格者。 2.负责细胞培养、组织配型、微生物、深低温冻存及融化、质量保证的人员应具有医学或相关学科本科以上学历,4年以上专业工作经历,并具有丰富的相关专业技术经验和较高的业务指导水平。 3.负责档案资料的人员应具相关专业中专以上学历,具有计算机基础知识和一定的医学知识,熟悉脐带血库的生产全过程。 4.负责其它业务工作的人员应具有相关专业大学以上学历,熟悉相关业务,具有2年以上相关专业工作经验。 (三)各部门工作人员任职条件 1.脐带血采集人员为经过严格专业培训的护士或助产士职称以上卫生专业技术人员并经考核合格者。 2.脐带血处理技术人员为医学、生物学专业大专以上学历,经培训并考核合格者。 3.脐带血冻存技术人员为大专以上学历、经培训并考核合格者。 4.脐带血库实验室技术人员为相关专业大专以上学历,经培训并考核合格者。 三、建筑和设施 (一)脐带血库建筑选址应保证周围无污染源。 (二)脐带血库建筑设施应符合国家有关规定,总体结构与装修要符合抗震、消防、安全、合理、坚固的要求。 (三)脐带血库要布局合理,建筑面积应达到至少能够储存一万份脐带血的空间;并具有脐带血处理洁净室、深低温冻存室、组织配型室、细菌检测室、病毒检测室、造血干/祖细胞检测室、流式细胞仪室、档案资料室、收/发血室、消毒室等专业房。 (四)业务工作区域应与行政区域分开。

精神分裂症患者在怎样的情况下会自杀

精神分裂症患者在怎样的情况下会自杀 精神分裂症是最常见的一种精神病。早期主要表现为性格改变,如不理采亲人、不讲卫生、对镜子独笑等。病情进一步发展,即表现为思维紊乱,病人的思考过程缺乏逻辑性和连贯性,言语零乱、词不达意。精神分裂症患者随时有可能出现危险行为,这主要是指伤人毁物、自伤自杀和忽然出走。这些危险行为是受特定的精神症状支配的.那么精神分裂症患者在什么情况下会自杀呢? 被害妄想:这是所有精神病人最常见的症状之一,多数病人采取忍耐、逃避的态度,少数病人也会“先下手为强”,对他的“假想敌”主动攻击。对此,最重要的是弄清病人的妄想对象,即:病人以为是谁要害他。假如病人的妄想对象是某个家里人,则应尽量让这位家属阔别病人,至少不要让他与病人单独在一起。 抑郁情绪:精神分裂症病人在疾病的不同时期,可能出现情绪低落,甚至悲观厌世。特别需要留意的是,有相当一部分自杀成功的病人,是在疾病的恢复期实施自杀行为的。病人在精神病症状消除以后,因自己的病背上了沉重的思想包袱,不能正确对待升学、就业、婚姻等现实问题,感到走投无路,因此选择了轻生。对此,家属一定要防患于未然,要尽早发现病人的心理困扰,及时疏导。 对已经明确表示出自杀观念的病人,家属既不要惊慌失措,也不要躲躲闪闪,要主动与病人讨论自杀的利弊,帮助病人全面、客观地评估现实中碰到的各种困难,找出切实可行的解决办法。 另外,这种病人在自杀之前,是经过周密考虑,并且做了充分预备的,例如写遗书、收拾旧物、向家人离别、选择自杀时间、预备自杀工具等。这类病人的自杀方式也是比较温顺的,多数是服药自杀。因此,他需要一定的时间来积攒足足数目的药物,这时就能看出由家属保管药品的重要性了。只要家属密切观察病人的情绪变化,是不难早期发现病人的自杀企图的。 药源性焦虑:抗精神病药的副作用之一是可能引起病人莫名的焦躁不安、手足无措,并伴有心慌、出汗、恐惧等。这些表现多是发作性的,多数发生在下午到傍晚时分,也有的病人在打长效针以后的2?3天内出现上述表现。这种时间上的规律性,有助于家属判定病人的焦虑情绪是否由于药物所致。病人急于摆脱这种强烈的痛苦,会出现冲动伤人或自伤,这些行为只是为了发泄和解脱,并不以死为终极目的。家属可以在病人发作时,给他服用小剂量的安定类药物,或者在医生的指导下,调整抗精神病药的剂量或品种,这样就可以有效地控制病人的焦虑发作。 极度兴奋:病人的精神症状表现为严重的思维紊乱、言语杂乱无章、行为缺乏目的性,这类病人也可能出现自伤或伤人毁物。由于病人的兴奋躁动是持续性的,家属有充分的思想预备,一般比较轻易防范。家属要保管好家里的刀、剪、火、煤气等危险物品,但最根本的办法,是使用大剂量的、具有强烈镇静作用的药物来控制病人的兴奋。假如在家里护理病人确有困难,则可以强制病人住院治

相关文档
最新文档