5-10 GeV Neutrinos from Gamma-Ray Burst Fireballs

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组蛋白脱乙酰酶抑制剂使癌细胞对表皮生长因子抑制剂敏感[发明专利]

组蛋白脱乙酰酶抑制剂使癌细胞对表皮生长因子抑制剂敏感[发明专利]

专利名称:组蛋白脱乙酰酶抑制剂使癌细胞对表皮生长因子抑制剂敏感
专利类型:发明专利
发明人:萨米尔·E·威塔,小保罗·A·邦恩,哈里·A·德拉布金,罗伯特·M·格米尔,丹尼尔·钱
申请号:CN200680016308.9
申请日:20060313
公开号:CN101175492A
公开日:
20080507
专利内容由知识产权出版社提供
摘要:本发明公开了组蛋白脱乙酰酶抑制剂和表皮生长因子受体(EGFR)抑制剂的组合用于治疗癌症的用途。

申请人:科罗拉多大学董事会
地址:美国科罗拉多州
国籍:US
代理机构:北京市柳沈律师事务所
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科学家发现一种有助于抑郁症治疗的小分子

科学家发现一种有助于抑郁症治疗的小分子

科学家发现一种有助于抑郁症治疗的小分子作者:暂无来源:《乡村科技》 2014年第7期加拿大麦吉尔大学和道格拉斯研究所的科学家,日前发现了一种只有在人体和其他灵长类动物大脑中存在的小分子。

当这种分子水平变低时容易导致沮丧抑郁等情绪。

这一发现有望将抑郁症的治疗提高到一个新层次。

相关论文发表在最近出版的《自然·医学》杂志上。

现代社会生活节奏快,工作压力大,抑郁症患者有日渐增多的趋势。

目前虽然也有一些治疗药物,但由于缺乏针对性,疗效并不明显。

新研究中,加拿大麦吉尔大学医学院附属道格拉斯医院心理科主任医师,抑郁症治疗中心主任古斯塔沃·德瑞奇教授带领的研究团队发现了一种名为miR-1202 的小分子。

这种分子有可能为抑郁症的治疗提供一个新的着力点,并且通过对这种分子含量的测试还可以发现潜在的抑郁症风险。

物理学家组织网6月9日(北京时间)报道称,通过对道格拉斯贝尔加拿大大脑库中样本的分析和对比,德瑞奇的研究团队发现miR-1202 是抑郁症患者大脑样本与健康大脑样本的一项重要区别。

他说:“我们发现在人体和其他灵长类动物大脑中,miR-1202是调节神经递质谷氨酸的重要受体。

我们进行了多次实验,结果表明抗抑郁药物能够改变这种分子的水平。

在临床实验中,我们也发现,在治疗前,抑郁症患者体内miR-1202 含量水平要显著低于没有抑郁症的健康个体。

很显然这种物质能够帮助人体对抗抑郁反应。

”德瑞奇说,目前包括西酞普兰(一种常见的抑郁症治疗药物)在内的一些药物确实能够帮助一些患者减轻痛苦,但在此之前往往要经过对多种药物的尝试后才能发现真正起效的那一种。

而如果能够引入对miR-1202的测试,并根据患者体内这种分子含量的水平对症下药,情况或许就会完全不同。

这一发现可能为“新的、更有效地抑郁症疗法”提供帮助。

来源:《科技日报》。

治疗癌症的“奇兵”——微纳米马达

治疗癌症的“奇兵”——微纳米马达

142Univ. Chem. 2023, 38 (11), 142–147收稿:2023-04-10;录用:2023-09-04;网络发表:2023-09-12*通讯作者,Email:********************.cn基金资助:国家自然科学基金(52073071);黑龙江省自然科学基金优秀青年基金(YQ2022E021)•科普• doi: 10.3866/PKU.DXHX202304034 治疗癌症的“奇兵”——微纳米马达姜满乐1,张荡1,张箭2,徐平1,王磊1,*1哈尔滨工业大学化工与化学学院,哈尔滨150001 2哈尔滨医科大学基础医学院,哈尔滨 150081摘要:目前癌症的发病率正在逐渐上升,为实现精准且低毒害的治疗目标,科学家们设计了智能的微纳米马达材料。

这类微小的智能装置可在外界条件控制下靶向于甚至进入癌细胞,从而靶向运输药物,最终实现癌症的治疗。

为了使这项技术得到更广泛的认识,本文采用拟人化手法,以微纳米马达与免疫细胞共同消灭癌细胞的故事为主体,简单介绍微纳米马达的制备、驱动方式以及治疗原理。

关键词:微纳米马达;癌症治疗;微纳米机器人;靶向治疗;免疫治疗中图分类号:G64;O6Micro/nanorobots: An “Ingenious Shocking Military” towards Cancer TreatmentManle Jiang 1, Dang Zhang 1, Jian Zhang 2, Ping Xu 1, Lei Wang 1,*1 School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.2 School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China.Abstract: In recent decades, an escalating incidence of tumors has been observed, necessitating more precise and less side-effect-prone therapies. Micro/nanorobots have been successfully engineered to address this challenge. These minute intelligent machines are capable of navigating to, and even infiltrating, tumor cells or tissues under external control. This enables targeted drug delivery and precise tumor therapy. To elucidate this sophisticated technology to a general audience, this paper adopts a personification style. Utilizing an engaging “battle narrative between micro/nanorobots and tumor cells”, we briefly outline the design, fabrication, propulsion mechanisms, and therapeutic principles for a wider readership.Key Words: Micro/nanomotors; Tumor treatment; Micro/nanorobots; Targeted treatment; Immunotherapy1 癌细胞规避免疫,微纳米马达助消病魔一位患者体内的癌细胞正在疯狂增殖,而他的免疫细胞却仿佛抛弃了它们的主人似的,对着极有危害的敌人置若罔闻。

日本和匈牙利共同开发出改善记忆力药品

日本和匈牙利共同开发出改善记忆力药品

日本和匈牙利共同开发出改善记忆力药品
佚名
【期刊名称】《医学信息》
【年(卷),期】1996(000)012
【摘要】日本和匈牙利共同开发出改善记忆力药品据《日经产业新闻》报道,日本武田药品工业公司和匈牙利制药企业格德翁·利赫特公司,共同开发出一种新型的改善记忆力的药品。

这种药防止神经细胞死亡,并且有促进神经成长因子分泌的作用。

神经成长因子能够使受伤的神经再生。

研究...
【总页数】2页(P16-17)
【正文语种】中文
【中图分类】R977.9
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灌肠咖啡历史、谷胱甘肽GST、烘焙知识小讲解

灌肠咖啡历史、谷胱甘肽GST、烘焙知识小讲解

灌肠咖啡历史、谷胱甘肽GST、烘焙知识小讲解早在两千年前,在欧洲的古书中就已有关于灌肠的记载。

而第一次世界大战时,德军的伤员在开刀的时候,因为缺乏麻醉剂及吗啡,因咖啡灌肠有止痛的效果,曾被用来减轻病患的痛苦。

德国有两位医学院的教授以老鼠试验进行咖啡灌肠,发现不仅能清肠、止痛,还有促进肝脏排毒的效果,进而奠定了咖啡灌肠的医疗背景。

后被自然养生排毒之父马克思.葛森医生学习沿用,并为人们所熟知…葛森博士Max Gerson.M.D(1881~1959)德国人,移民美国,自然疗法权威人士。

早在1907,马克斯葛森医生就利用全素食为主的无盐饮食,搭配咖啡灌肠治愈了自己很严重、在当时被认为是不可根治的偏头痛。

新谷弘实教授现任美国阿尔伯特、爱因斯坦医科大学外科教授。

美国最权威的内视镜外科医生,担任欧美各国多名政要的保健医生。

新谷弘实教授是国际上著名的肠胃内窥镜发明人、同时也是咖啡灌肠人体肠道跟踪观测第一人。

1971年于美国肠胃内视镜协会发表70个案例,获得在场1000多位的医生起立喝彩,从此奠定了他在大肠内视镜手术界的地位。

他通过肠道观测及自身35年的咖啡灌肠亲身实践论证了:1、咖啡灌肠副作用、依赖性等问题不存在。

2、通过观测咖啡灌肠及补充益生菌对肠道的改善,提出了肠相论;即“肠相”美丽,身体年龄就更年轻。

3、咖啡灌肠对人体的众多疾病有预防和治疗的作用。

新谷弘实认为:1.肠内停滞的大便会产生有害物质。

因大便停滞的缘故,肠内也开始腐烂,产生有害物质,这些有害物质被肠吸收后,将会严重地损害人体的健康。

2.积存在肠内的粪便,会使肠内的坏细菌繁殖,并且随着血液一起在体内循环,不仅会使肠内污浊,而肠内环境恶化又会促进身体的老化,如果置之不理,这种恶性循环会一直持续下去;反过来说,若能用某些方法来制止肠内环境的恶化,就可以防止身体的老化。

1928年,葛森医生意外发现灌肠水疗不单能治愈偏头痛,更能治愈皮肤结核病,糖尿病等各种医学上都认为不能根治的病。

氯仿-甲醇提取贝氏柯克斯体组分Q热疫苗的免疫保护性评价

氯仿-甲醇提取贝氏柯克斯体组分Q热疫苗的免疫保护性评价
oc l e nt a p rt e ly wih t h uatd i r — e ion a l t he om o o us va cn w e ks a t r h i a y m m unz ton. The l go c i e 4 e fe t e prm r i ia i n, t e i oc l e m ie h n uatd c we e c le ge ih 1 oft iulntC.b ne i nt a e ion a w e ks a t r t os e i m u z ton O n e fe r ha ln d w t 0 he v r e ur tii r p rt e Uy 2 e fe he bo t r m nia i . e we k a t r c le ge, m iew e e s c iie nd t i ple e e c lc e nd t ha ln c r a rfc d a hers e nsw r ole t d a hebur nsofC. r e i n s e nsw e ede e t d byqu — de bu n tii ple r t c e an tt tvepo y e a ec i e c i ia i l m r s han r a ton. I wa f und ha h r e o bu n ti n ple ie i m u z d t s o t tt e bu d n f C. r e i i s e ns ofm c m nie wih CM RV o t r W CV r i fc nty l we e sgniia l owe ha ha n i m unie m ie a o sgn fc n fe e e i r t n t tofu m z d c nd n i iia tdif r nc n bur ns o b ne i a oun de fC. ur tiw s f d b t e n ie i m unie ih CM RV n CV . I a iin, t e w e m c m zd w t adM n dd to hebur n ofC.b ne i n t p e n ie i m unie ih de ur tii he s l e s ofm c m zd w t 1 0 g ofva cne wa i niia l owe ha ha fm iei m u z d w ih 1 / fva cn hc sm a ke y lw e ha h t 0 c i s sg fc nty l rt n t to c m nie t 0 * o c i e w ih wa r dl o rt n t a g o ie i m un z d wih 1 “g ofva cne Cole tv l fm c m ie t ci . l ci e y,i ppe r h tCM RV r p r d wih t ta a st a p e a e t heChi s s a e b n tii ne e iolt sofC. ur e i s e fc cous O p o e tm ie f o i e ton w ih C. ur ti f ia i t r t c c r m nf c i t b ne i.

不同分期恶性肿瘤患者外周血凝血功能指标、NLR检测及其临床意义

不同分期恶性肿瘤患者外周血凝血功能指标、NLR检测及其临床意义

病变的相关性分析[J].医学临床研究,2020,37(5):680-682.[17]Medina-Leyte DJ,Zepeda-García O,Domínguez-Pérez M,et al.En-dothelial dysfunction,inflammation and coronary artery disease:po-tential biomarkers and promising therapeutical approaches [J].Int J Mol Sci,2021,22(8):3850.[18]Kwon Y ,Kim M,Kim Y ,et al.EGR3-HDAC6-IL -27axis mediatesallergic inflammation and is necessary for tumorigenic potential of cancer cells enhanced by allergic inflammation-promoted cellular in-teractions [J].Front Immunol,2021,12(1):680441.[19]Nie F,Zhang Q,Ma J,et al.Schizophrenia risk candidate EGR3is anovel transcriptional regulator of RELN and regulates neurite out-growth via the Reelin signal pathway in vitro [J].J Neurochem,2021,157(6):1745-1758.[20]Shin SH,Kim I,Lee JE,et al.Loss of EGR3is an independent riskfactor for metastatic progression in prostate cancer [J].Oncogene,2020,39(36):5839-5854.[21]Hua Y ,Wang H,Ye Z,et al.An integrated pan-cancer analysis ofidentifying biomarkers about the EGR family genes in human carci-nomas [J].Comput Biol Med,2022,148(1):105889.(收稿日期:2023-09-18)不同分期恶性肿瘤患者外周血凝血功能指标、NLR 检测及其临床意义赵娜1,赵宁2,申晓楠1,苗雨莉11.通用环球西安西航医院检验科,陕西西安710021;2.西安医学院药学院,陕西西安710021【摘要】目的探讨不同分期恶性肿瘤患者外周血凝血功能指标、中性粒细胞/淋巴细胞比值(NLR)检测及其临床意义。

哌嗪磺酸衍生物作为CCR1拮抗剂用于治疗纤维化、阿尔茨海默病和其它病症的用途[发明专利]

哌嗪磺酸衍生物作为CCR1拮抗剂用于治疗纤维化、阿尔茨海默病和其它病症的用途[发明专利]

专利名称:哌嗪磺酸衍生物作为CCR1拮抗剂用于治疗纤维化、阿尔茨海默病和其它病症的用途
专利类型:发明专利
发明人:M·F·布朗,A·S·加韦科,R·P·格拉迪,M·M·海沃德
申请号:CN200380102266.7
申请日:20031020
公开号:CN1708304A
公开日:
20051214
专利内容由知识产权出版社提供
摘要:本发明涉及作为免疫调节剂使用CCR1拮抗剂的方法。

具体而言,该方法涉及使用式(I)化合物或其可药用盐:其中X、Y、a、b、c、d、R、R、R和R如此处所定义。

申请人:辉瑞产品公司
地址:美国康涅狄格州
国籍:US
代理机构:北京市中咨律师事务所
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a r X i v :h e p -p h /0004019v 4 23 J u n 20005-10GeV Neutrinos from Gamma-Ray Burst FireballsJohn N.Bahcall 1&Peter M´e sz´a ros 1,21Institute for Advanced Study 2Pennsylvania State UniversityA gamma-ray burst fireball is likely to contain an admix-ture of neutrons,in addition to protons,in essentially all pro-genitor scenarios.Inelastic collisions between differentially streaming protons and neutrons in the fireball produce νµ(¯νµ)of ∼10GeV as well as νe (¯νe )of ∼5GeV,which could produce∼7events/year in km 3detectors,if the neutron abundance is comparable to that of protons.Photons of ∼10GeV from π0decay and ∼100MeV ¯νe from neutron decay are also produced,but will be difficult to detect.Photons with ener-gies ∼<1MeV from shocks following neutron decay produce a characteristic signal which may be distinguishable from the proton-related MeV photons.I.INTRODUCTIONGamma-ray burst (GRB)sources are distributed throughout the universe and their energy output is mea-sured to be a substantial fraction of a solar rest mass equivalent.1A variety of observations support the in-terpretation that these events are caused by cataclysmic stellar collapse or compact mergers,producing a fireball with bulk expansion Lorentz factor Γ∼102−103.In the standard GRB model a fireball made up of γ,e ±and magnetic fields with an admixture of baryons is producedby the release of a large amount of energy E ∼>1053ergs in a region r o ∼107r o 7cm (e.g.2).The observations indicate that typical fireballs are characterized by a lu-minosity L ∼1052L 52erg s −1and durations t w =10t w 1s in the observer frame,with a large spread in both quanti-ties.The outflow is controlled by the value of the dimen-sionless entropy η=(L/˙Mc2)injected at r o .Previous discussions of fireball models have generally focused on the charged particle components,since they determine directly the photon signal.However,consideration of a neutron component introduces qualitatively new effects.3In a p,n fireball,for values of η∼>400,the neutrons and protons acquire a relative drift velocity causing inelastic n,p collisions and creating neutrinos.We investigate here the neutrino and photon signals from n,p collisions following decoupling in GRB.The ∼10GeV neutrinos from this mechanism depend upon the presence of neutrons in the original explosion,but the neutrinos are created in simple physical processes occur-ring in the later stages of the fireball.On the other hand,the 105GeV neutrinos discussed in refs.4require the ac-celeration in shock waves of ultra-high energy protons interacting with photons.Thus the 10GeV and the 105GeV neutrinos reflect very different astrophysical pro-cesses and uncertainties.Other processes,e.g.neutrinos from p,p collisions 5also require shocks but have lower efficiencies,while 10-30MeV neutrinos from the original explosion 6are much harder to detect due to the lower cross sections.We show (§III)that the 10GeV neutrinos could be detectable by future km 3size detectors.The associated ∼10GeV γ-ray fluences are compatible with current de-tection rates,and may be detectable with future space missions.The dependence of these signals on the neu-tron/proton ratio ξprovides a new tool to investigate the nature of the GRB progenitor systems.Moreover the predicted neutrino event rate depends on the asymp-totic bulk Lorentz factor of the neutrons,which is linked to that of the protons.The latter affects all the electro-magnetic observables from the GRB fireball,including the photospheric and shock radii,as well as the particle acceleration and non-thermal photon production.II.DYNAMICS,N-P DECOUPLING AND PIONSAbove the fireball injection radius r o the outflow ve-locity increases through conversion of internal energy into kinetic energy,the bulk Lorentz factor Γvaryingas Γ∼T ′o /T ′=r/r o ,where T ′is the comoving tem-perature and T ′o =1.2L 1/452r −1/2o 7MeV is the initial tem-perature at r o (henceforth denoting with primes quan-tities measured in the comoving frame).The flow may be considered spherical,which is a valid approximation also for a collimated outflow of opening angle θj >Γ−1,for the conditions discussed here.In a pure proton out-flow the linear growth of Γsaturates when it reaches an asymptotic value Γf ≤η∼constant,the value ηbe-ing achieved when the fireball converts all its luminosity into expansion kinetic energy.For an n,p fireball,be-yond the injection radius r o the comoving temperature is low and nuclear reactions are rare,so the n/p ratio ξremains constant.Since the thermal velocities are non-relativistic,decoupling of the n and p fluids is essential for high-energy neutrino production.At the base of the outflow the n and p components are coupled by nuclear elastic scattering.In terms of the CM relative energy ǫrel and the relative velocityv rel between nucleons,σ′elv ′rel ∼σo c .The CM en-ergy dependence σel ∝ǫ′−1/2∝v ′−1rel is approximately 1valid between energies ∼MeV and the pion produc-tion threshold ∼140MeV,and σo ∼σπ∼3×10−26cm 2is the pion formation cross section above thresh-old.The p and n are cold in the comoving frame,and remain well coupled until the comoving n,p scatteringtime t ′np ∼(n ′p σo c )−1becomes longer than the comov-ing expansion time t ′exp ∼r/c Γ.Denoting the comovingneutron density n ′n =ξn ′p with ξ∼<1,mass conservationimplies n ′p =L/[(1+ξ)4πr 2m p c 3Γη].The n,p decoupling occurs in the coasting or accelerating regimes depending on whether the dimensionless entropy ηis below or above the critical valueηπ= Lσπ/4πm p c 3r o (1+ξ)1/4≃3.9×102L 1/452r −1/4o 7([1+ξ]/2)−1/4.(1)Figure 1shows the dependence of Γon radius for differentη.For low values,η∼<ηπ,the condition t ′np ∼>t ′exp isachieved at a radius r np /r o =ηπ(ηπ/η)3,which is beyond the saturation radius r s /r o ∼ηat which both n and p start to coast with Γ∼η=constant.In this case,even after decoupling both n and p continue to coast together due to inertia,and their relative velocities never reach the threshold for inelastic collisions.ηπηπ,2np r ,1np r ( )r lg Γr/r 012pn2lg lg lg FIG.1.Schematic behavior of the bulk Lorentz factor Γas a function of radius r for various values of the dimensionless entropy η,the decoupling radius r np being indicated with a diagonal slash.Curve 1is for η<ηπ,where the n and p achieve the same asymptotic Γnf ∼Γpf ∼η.Curve 2is for η>ηπ,and in this case n,p decoupling occurs before protons have reached their asymptotic Lorentz factor,which is larger than that of neutrons.This leads to inelastic n,p collisions,pion formation and neutrino emission at r np,2.For η∼>ηπ,on the other hand,the n,p decoupling con-dition t ′np ∼>t ′exp occurs while the protons (and neutrons)are still accelerating as Γp ≃(r/r o ),at a radius(r np /r o )=ηπ(η/ηπ)−1/3,for η∼>ηπ.(2)Beyond this decoupling radius the p can still continue toaccelerate with Γp ∝r (as long as they remain coupledto the photons).However the neutrons are no longer accelerated,since they only interact with the protons,and they continue to coast with the value of Γ∼Γnf ≃constant achieved up to that point,Γnf =(3/4)ηπ(η/ηπ)−1/3(forη∼>ηπ)≃3×102L 1/452r −1/4o 7([1+ξ]/2)−1/4(η/ηπ)−1/3,(3)where the (3/4)factor comes from a numerical solution 3of the coupling equations.When the n,p decoupling condition η∼>ηπis satisfied,the relative n,p drift velocity v rel →c and the inelastic pion production threshold ǫ′>140MeV is reached.Sinceσo ∼σπ,the condition t ′np ∼t ′exp implies that the opticaldepth to pion formation is of order unity.Thus,for η∼>ηπthe radius r np ≡r πis not only a decoupling radius but also an effective “pionospheric”radius.The lowest energy threshold processes at r πare p +n →p +p +π−→µ−+¯νµ→e −+¯νe +νµ+¯νµ→n +n +π+→µ++νµ→e ++νe +¯νµ+νµ→p +n +π0→γ+γ,(4)which occur in approximately equal ratios and with nearunit total probability.The corresponding p +p (n +n )→π±,π0processes do not involve a relative drift velocity (as do the p +n ),and are thus less probable.Processes leading to multiple baryons are also suppressed due to the higher threshold,and for simplicity we restrict ourselves to the above p +n processes.III.10GEV NEUTRINOS AND γ-RAYSThe total number of neutrons carried by the fireball isN n = ξηm p c 2∼0.83×1053E 53 2ξη ,(5)The comoving optical depth τ′∼n ′p σr/Γ∝σ/(r Γ)hasthe same dependence for pion formation and photon scat-tering,but σπ≪σT (Thomson cross section),so the pi-onosphere r πoccurs below the γ-photosphere r γ.The γ-rays in equation (4)can only escape from a skin depth be-low the γ-sphere in the essentially laminar flow with prob-ability P γ∼<τπ(r γ)∼r π/r γ∼(σπ/σT )(1+ξ/7)2∼1/25,for η∼>ηπ.Each n leads to ∼1photon of CM en-ergy ǫ′γ∼70MeV and observer energy centered broadly around ǫγ∼70Γnf /(1+z )MeV ∼ing a proper distance D p =2.8×1028h −165[1−1/√The neutrinos originate at the pionospheric radius rπ≪rγwhereτπ∼1.In this region the stable charged products andγ-rays from the reactions(4)remain in the fireball,and each n leads on average to oneνand one ¯ν.We list below the average neutrino energies for pions and muons decaying at rest.The neutrinos from muon decay have a continuum spectrum.Also,the energies are Doppler broadened by v rel/c∼0.5.ǫ′¯νµ≃30MeV,ǫ′νµ≃30MeV fromπ±ǫ′νe≃30MeV,ǫ′¯νµ≃50MeV fromµ+,(6)ǫ′¯νe≃30MeV,ǫ′νµ≃50MeV fromµ−The relevant cross section for detection averaged overνand¯νisσν∼0.5×10−38(ǫ/GeV)cm2at the observed en-ergyǫ.9The observer frame energy isǫ=ǫ′αΓnf/(1+z), whereα∼1near threshold.For the CMν¯νproduction energies of equation(6),the averageν+¯νCM energy per neutron isǫ′≃100MeV.Takingα≃1the observer ν+¯νenergy per neutron isǫ≃0.1Γnf/(1+z)GeV, and the effective detection cross section per neutron isσν¯νisRν¯νµ∼7E53N t39R b3 2ξη 4/3×h265 2−√1+z−√5×1051E53(2ξ/[1+ξ])(2/[1+z])(ηπ/η)4/3ergs depends on the total energy E of the GRB and on the neu-tron fractionξas well as on the dimensionless entropy η.For a km3detector,approximately5to10neutrino events above10GeV are predicted per year,for a neu-tron/proton ratioξ=1.These events will be coinci-dent with GRB electromagneticflashes in direction and in time(to an accuracy of∼10s),which can enable their separation from the atmospheric neutrino background. Underground water detectors of the type being planned by BAIKAL,13NESTOR,14ANTARES15and the Antar-tic detector ICECUBE16could potentially detect these relatively low energy neutrino events if a sufficiently high density of phototubes were used.About80%of these neutrinos areνµand¯νµ(in approximately equal num-bers)and the remainder areνe and¯νe.These5-10Gev ν¯νare followed by∼120MeV¯νe from neutron decay, but the event rate from neutron-decay neutrinos is very low.The higher energy neutrinos are produced for neu-tron/proton ratiosξ>0when the dimensionless entropyη=L/˙Mc2exceedsηπ≃4×102L1/452r−1/4o7(2/[1+ξ])1/4,and are accompanied by∼10GeV photons which may be detectable in low redshift cases with GLAST.8For a typical GRB at redshift z∼1the numberfluences in10 GeV neutrinos are N(¯νe+νe)∼0.5N(¯νµ+νµ)∼10−4 cm−2,and one order of magnitude less for GeV photons.In all bursts whereξ>0the lower energy(∼120MeV) neutrinos are produced,and neutron decay occurs on anobserver timescale t n∼3L−1/452r1/4o7[(1+ξ)/2]1/4(η/ηπ)1/3s.For outflows of duration t w,these decays will be as-sociated with MeV electromagnetic pulses of duration min[t n,t w],which are additional to the MeV pulses ex-pected from shocks in the original proton component. For short bursts with t w∼<3s,the proton electromag-netic pulse appearsfirst and is separated from a subse-quent neutron electromagnetic pulse,the latter having a slow rise-fast decay envelope and a softer spectrum, which may be detectable with the Swift satellite.12A systematic study of the time histories of GRB emission would be useful to search for evidence of delayed pulses that might be caused by neutron decay.The detection of5-10GeVν¯νin coincidence with GRB photonflashes will not be easy,but would provide unique astrophysical information.Constraints on the neutron fraction could provide information about the progenitor stellar system giving rise to GRB.For instance,core col-lapse of massive stars would lead to an outflow from an F e-rich core withξ∼2/3−1,while neutron star merg-ers would implyξ≥1.Photodissociation during collapse or merger,as well as n,p decoupling and inelastic colli-sions,would both driveξtoward unity,although this equalization process is likely to remain incomplete.For lowη∼<ηπ,inelastic collisions are not expected and the 5-10GeVν¯νare absent,producing only the harder to detect∼100MeV¯νe from neutron decay.An initially non-baryonic outflow of,e.g.e±and magneticfields, would acquire a baryonic load by entrainment from the progenitor environment,withξ≪1from massive stellar envelopes,butξ∼>1for,e.g.,compact mergers.Thus, lower values ofξ,leading to lower ratios of5-10GeVν¯νand a lower ratio of neutron decay MeV photons to to-talfluences would be expected from massive progenitors than from compact mergers.AcknowledgementsPartial support was received by JNB from NSF PHY95-13835and by PM from NASA NAG5-2857,the Guggen-heim Foundation and the Institute for Advanced Study. We acknowledge valuable conversations with G.Fishman, V.Fitch,Vl.Kocharovsky,P.Kumar,R.Nemiroff,J. Norris,M.J.Rees,P.Vogel and E.Waxman.。

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