INCB 024360_1204669-58-8_DataSheet_MedChemExpress
第一三共在日本提交CS-8958的新药申请
第一三共在日本提交CS-8958的新药申请
无
【期刊名称】《国外药讯》
【年(卷),期】2010(000)003
【摘要】日本第一三共公司表示已将一种有专利权的抗流感新药CS-8958的申请提交到日本厚生省。
CS-8958是一种长效神经氨酸酶抑制剂laniflamivir的前体药物，这种药物是由第一三共公司和其澳大利亚合作伙伴Biota公司合作完全为日本市场开发的，该药物会以吸入剂的方式直接作用于呼吸道。
【总页数】1页(P21)
【作者】无
【作者单位】无
【正文语种】中文
【中图分类】R951
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刊名简称刊名全称ATMOS CHEM PHYS ATMOSPHERIC CHEMISTRY AND PHYSICSB AM METEOROL SOC BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY CLIM DYNAM CLIMATE DYNAMICSCONTRIB MINERAL PETR CONTRIBUTIONS TO MINERALOGY AND PETROLOGY EARTH PLANET SC LETT EARTH AND PLANETARY SCIENCE LETTERSEARTH-SCI REV EARTH-SCIENCE REVIEWSGEOCHIM COSMOCHIM AC GEOCHIMICA ET COSMOCHIMICA ACTAGEOLOGY GEOLOGYGEOTEXT GEOMEMBRANES GEOTEXTILES AND GEOMEMBRANESJ CLIMATE JOURNAL OF CLIMATEJ PETROL JOURNAL OF PETROLOGYLIMNOL OCEANOGR LIMNOLOGY AND OCEANOGRAPHYNAT GEOSCI Nature GeosciencePALEOCEANOGRAPHY PALEOCEANOGRAPHYPRECAMBRIAN RES PRECAMBRIAN RESEARCHQUATERNARY SCI REV QUATERNARY SCIENCE REVIEWSREV GEOPHYS REVIEWS OF GEOPHYSICSGEOPHYS RES LETT GEOPHYSICAL RESEARCH LETTERSJ ATMOS SCI JOURNAL OF THE ATMOSPHERIC SCIENCESJ GEOPHYS RES JOURNAL OF GEOPHYSICAL RESEARCHJ HYDROL JOURNAL OF HYDROLOGYMON WEATHER REV MONTHLY WEATHER REVIEWANNU REV ASTRON ASTR ANNUAL REVIEW OF ASTRONOMY AND ASTROPHYSICS ASTRON ASTROPHYS REV ASTRONOMY AND 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NATURE NEUROSCIENCENAT REV CANCER NATURE REVIEWS CANCERNAT REV DRUG DISCOV NATURE REVIEWS DRUG DISCOVERYNAT REV IMMUNOL NATURE REVIEWS IMMUNOLOGYNAT REV NEUROSCI NATURE REVIEWS NEUROSCIENCENEUROLOGY NEUROLOGYNEURON NEURONNEUROPSYCHOPHARMACOL NEUROPSYCHOPHARMACOLOGYNEUROSCI BIOBEHAV R NEUROSCIENCE AND BIOBEHAVIORAL REVIEWSNEW ENGL J MED NEW ENGLAND JOURNAL OF MEDICINEOBES REV Obesity ReviewsONCOGENE ONCOGENEPHARMACOL REV PHARMACOLOGICAL REVIEWSPHARMACOL THERAPEUT PHARMACOLOGY & THERAPEUTICSPHYSIOL REV PHYSIOLOGICAL REVIEWSPHYSIOLOGY PHYSIOLOGYPLOS MED PLOS MEDICINEPROG NEUROBIOL PROGRESS IN NEUROBIOLOGYPROG RETIN EYE RES PROGRESS IN RETINAL AND EYE RESEARCHPSYCHOL BULL PSYCHOLOGICAL BULLETINPSYCHOL REV PSYCHOLOGICAL REVIEWREV MED VIROL REVIEWS IN MEDICAL VIROLOGYSCHIZOPHRENIA BULL SCHIZOPHRENIA BULLETINSEMIN CANCER BIOL SEMINARS IN CANCER BIOLOGYSEMIN IMMUNOL SEMINARS IN IMMUNOLOGYSTEM CELLS STEM CELLSSTROKE STROKETHORAX THORAXTRENDS COGN SCI TRENDS IN COGNITIVE SCIENCESTRENDS ENDOCRIN MET TRENDS IN ENDOCRINOLOGY AND METABOLISMTRENDS IMMUNOL TRENDS IN IMMUNOLOGYTRENDS MOL MED TRENDS IN MOLECULAR MEDICINETRENDS NEUROSCI TRENDS IN NEUROSCIENCESTRENDS PHARMACOL SCI TRENDS IN PHARMACOLOGICAL SCIENCESWHO TECH REP SER WHO TECHNICAL REPORT SERIESAM J CARDIOL AMERICAN JOURNAL OF CARDIOLOGYAM J EPIDEMIOL AMERICAN JOURNAL OF EPIDEMIOLOGYAM J PATHOL AMERICAN JOURNAL OF PATHOLOGYAM J PHYSIOL-HEART C AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULA ANTIMICROB AGENTS CH ANTIMICROBIAL AGENTS AND CHEMOTHERAPYBRIT J CANCER BRITISH JOURNAL OF CANCERCANCER-AM CANCER SOC CANCERCHEST CHESTCNS NEUROL DISORD-DR CNS & Neurological Disorders-Drug Targets ENDOCRINOLOGY ENDOCRINOLOGYEUR J NEUROSCI EUROPEAN JOURNAL OF NEUROSCIENCEFREE RADICAL BIO MED FREE RADICAL BIOLOGY AND MEDICINEINFECT IMMUN INFECTION AND IMMUNITYINT J CANCER INTERNATIONAL JOURNAL OF CANCERINT J RADIAT ONCOL INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOL INVEST OPHTH VIS SCI INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEJ APPL PHYSIOL JOURNAL OF APPLIED PHYSIOLOGYJ CLIN ENDOCR METAB JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM J CLIN MICROBIOL JOURNAL OF CLINICAL MICROBIOLOGYJ COMP NEUROL JOURNAL OF COMPARATIVE NEUROLOGYJ IMMUNOL JOURNAL OF IMMUNOLOGYJ INFECT DIS JOURNAL OF INFECTIOUS DISEASESJ MED CHEM JOURNAL OF MEDICINAL CHEMISTRYJ NEUROCHEM JOURNAL OF NEUROCHEMISTRYJ NEUROPHYSIOL JOURNAL OF NEUROPHYSIOLOGYJ NUTR JOURNAL OF NUTRITIONJ PHARMACOL EXP THER JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPE J PHYSIOL-LONDON JOURNAL OF PHYSIOLOGY-LONDONJ UROLOGY JOURNAL OF UROLOGYJ VIROL JOURNAL OF VIROLOGYKIDNEY INT KIDNEY INTERNATIONALNEUROIMAGE NEUROIMAGENEUROSCIENCE NEUROSCIENCEPEDIATRICS PEDIATRICSRADIOLOGY RADIOLOGYTRANSPLANTATION TRANSPLANTATIONVIROLOGY VIROLOGYNATURE NATUREP NATL ACAD SCI USA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES SCIENCE SCIENCEANN NY ACAD SCI ANNALS OF THE NEW YORK ACADEMY OF SCIENCESISSN大类名称复分大类分区是否top期刊2009年影响因子1680-7316地学1Y 4.881 0003-0007地学1Y 6.123 0930-7575地学1Y 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2.874 0928-4249农林科学1Y 3.579 0044-8486农林科学2Y 1.925 0706-652X农林科学2Y 1.951 0378-1127农林科学2Y 1.950 0003-1488农林科学2Y 1.714 0032-079X农林科学2Y 2.517 1526-5161社会科学1Y 4.000 0012-9682社会科学1Y 4.000 0304-4076社会科学2Y 1.902 0002-9297生物1Y12.303 0066-4154生物1Y29.875 1056-8700生物1Y18.955 1936-122X生物1Y19.304 1081-0706生物1Y19.571 1543-592X生物1Y8.190 0066-4170生物1Y11.271 0066-4197生物1Y13.235 1527-8204生物1Y11.568 0066-4227生物1Y12.804 0066-4286生物1Y11.212 1543-5008生物1Y23.460 0092-8674生物1Y31.152 1931-3128生物1Y13.021 1550-4131生物1Y17.350 1934-5909生物1Y23.563 1040-9238生物1Y10.216 0960-9822生物1Y10.992 0955-0674生物1Y14.153 0959-437X生物1Y8.987 1369-5266生物1Y10.333 0959-440X生物1Y9.344 1534-5807生物1Y13.363 0890-9369生物1Y12.075 1088-9051生物1Y11.342 0021-9525生物1Y9.575 1092-2172生物1Y12.585 1097-2765生物1Y14.608 1744-4292生物1Y12.125 1465-7392生物1Y19.527 1552-4450生物1Y16.058 1061-4036生物1Y34.284 1548-7091生物1Y16.874 1471-0056生物1Y27.822 1740-1526生物1Y17.644 1471-0072生物1Y42.198 1545-9985生物1Y12.2731040-4651生物1Y9.293 1544-9173生物1Y12.916 1553-7390生物1Y9.532 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Trigonox B（滴苷但羊水）产品数据表单说明书
Product Data SheetTrigonox BDi-tert-butyl peroxideTrigonox® B is a pure peroxide in liquid form.CAS number110-05-4EINECS/ELINCS No. 203-733-6TSCA statuslisted on inventory Molecular weight 146.2Active oxygen contentperoxide10.94%SpecificationsAppearance Clear liquidAssay≥ 99.0 %ApplicationsTrigonox® B (Di-tert-butyl peroxide) can be used for the market segments: polymer production, polymer crosslinking and acrylics production with their different applications/functions. For more information please check our website and/or contact us.Half-life dataThe reactivity of an organic peroxide is usually given by its half-life (t½) at various temperatures. For Trigonox® B in chlorobenzene half-life at other temperatures can be calculated by using the equations and constants mentioned below:0.1 hr at 164°C (327°F)1 hr at 141°C (286°F)10 hr at 121°C (250°F)Formula 1kd = A·e-Ea/RTFormula 2t½ = (ln2)/kdEa153.46 kJ/moleA 4.20E+15 s-1R8.3142 J/mole·KT(273.15+°C) KThermal stabilityOrganic peroxides are thermally unstable substances which may undergo self-accelerating decomposition. The lowest temperature at which self-accelerating decomposition may occur with a substance in the packaging as used for transport is the Self-Accelerating Decomposition Temperature (SADT). The SADT is determined on the basis of the Heat Accumulation Storage Test.SADT80°C (176°F)Method The Heat Accumulation Storage Test is a recognized test method for thedetermination of the SADT of organic peroxides (see Recommendations on theTransport of Dangerous Goods, Manual of Tests and Criteria - United Nations, NewYork and Geneva).StorageDue to the relatively unstable nature of organic peroxides, a loss of quality will occur over a period of time. To minimize the loss of quality, Nouryon recommends a maximum storage temperature (Ts max. ) for each organic peroxide product.Ts Max.40°C (104°F) andTs Min.-30°C (-22°F) to prevent crystallizationNote When stored according to these recommended storage conditions, Trigonox® Bwill remain within the Nouryon specifications for a period of at least 6 months afterdelivery.Packaging and transportIn North America Trigonox® B is packed in non-returnable, five gallon polyethylene containers of 30 lb net weight and steel drums of 100 or 340 lb net weight. In other regions the standard packaging is a 30-liter HDPE can (Nourytainer®) for 20 kg peroxide. Delivery in a 200 l steel drum for 150 kg peroxide is also possible in a number of countries. Both packaging and transport meet the international regulations. For the availability of other packed quantities consult your Nouryon representative. Trigonox® B is classified as Organic peroxide type E; liquid, Division 5. 2; UN 3107.Safety and handlingKeep containers tightly closed. Store and handle Trigonox® B in a dry well-ventilated place away from sources of heat or ignition and direct sunlight. Never weigh out in the storage room. Avoid contact with reducing agents (e. g. amines), acids, alkalis and heavy metal compounds (e. g. accelerators, driers and metal soaps). Please refer to the Safety Data Sheet (SDS) for detailed information on the safe storage, use and handling of Trigonox® B. This information should be thoroughly reviewed prior to acceptance of this product. The SDS is available at /sds-search.Major decomposition productsAcetone, Methane, tert-ButanolAll information concerning this product and/or suggestions for handling and use contained herein are offered in good faith and are believed to be reliable.Nouryon, however, makes no warranty as to accuracy and/or sufficiency of such information and/or suggestions, as to the product's merchantability or fitness for any particular purpose, or that any suggested use will not infringe any patent. Nouryon does not accept any liability whatsoever arising out of the use of or reliance on this information, or out of the use or the performance of the product. Nothing contained herein shall be construed as granting or extending any license under any patent. Customer must determine for himself, by preliminary tests or otherwise, the suitability of this product for his purposes.The information contained herein supersedes all previously issued information on the subject matter covered. The customer may forward, distribute, and/or photocopy this document only if unaltered and complete, including all of its headers and footers, and should refrain from any unauthorized use. Don’t copythis document to a website.Trigonox® and Nourytainer are registered trademarks of Nouryon Functional Chemicals B.V. or affiliates in one or more territories.Contact UsPolymer Specialties Americas************************Polymer Specialties Europe, Middle East, India and Africa*************************Polymer Specialties Asia Pacific************************2022-6-30© 2022Polymer crosslinking Trigonox B。
TechnicalDataSheetPurifiedMouseAnti-Paxillin
BD Transduction Laboratories™Technical Data SheetBioimaging Certified ReagentPurified Mouse Anti-PaxillinProduct InformationMaterial Number:610569Size:150 µg Concentration:250 µg/ml Clone: 177/PaxillinImmunogen:Chicken Paxillin aa. 1-557Isotype:Mouse IgG1QC Testing: HumanTested in Development: Bovine, Chicken, Dog, Mouse, Rat Reactivity:68 kDaTarget Molecular Weight:Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.Storage Buffer:DescriptionPaxillin, a focal adhesion protein, is a substrate for several tyrosine kinases such as src, FAK, and p120BRC/ABL. The tyrosinephosphorylation of paxillin is affected by conditions that change cell-cell adhesion. This is consisent with the possibility that paxillin isinvolved in the regulation of cell morphology. Additionally, because of its SH3-binding domain, paxillin associates tightly with FAK and Crk in an extracellular matrix-independent manner. Although paxillin was initially detected in fibroblasts, its phosphorylation may be important during neurite extension during differentiation.This antibody is routinely tested by western blot and immunofluorescent imaging. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.Western blot analysis of Paxillin on a humanendothelial lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the anti-Paxillin antibody.Immunofluorescent staining of HeLa cells. Cells were seeded in a 96 well imaging plate (Cat. No. 353219) at ~10,000 cells per well. After overnight incubation, cells were stained using the methanol fix/perm protocol (below) and the anti-Paxillin antibody. The second step reagent was Alexa Fluor® 555 conjugated anti-mouse Ig(Invitrogen). The image was taken on a Pathway 850 imager using a 20x objective. This antibody also stained A549 and U2OS cells and worked with both the Triton X100 and methanol fix/perm protocols (see Recommended Assay Procedure).Preparation and StorageThe monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20° C.Application NotesApplicationBioimaging Routinely TestedWestern blot Routinely TestedImmunofluorescence Tested During DevelopmentImmunoprecipitation Not RecommendedImmunohistochemistry Not RecommendedRecommended Assay Procedure:Methanol Procedure for a 96 well plate:Remove media from wells. Add 100 µl/well fresh 3.7% Formaldehyde in PBS. Incubate for 10 minutes at room temperature (RT). Flick out and add 100 µl/well 90% methanol. Incubate for 5 minutes at RT. Flick out and wash twice with PBS. Flick out PBS and add 100 µl/well blocking buffer (3% FBS in PBS). Incubate for 30 minutes at RT. Flick out and add diluted antibody (diluted in blocking buffer). Incubate for 1 hour at RT. Wash three times with PBS. Flick out PBS and add second step reagent. Incubate for 1 hour at RT. Wash three times with PBS. Image sample.Triton-X 100 Procedure for a 96 well plate:Remove media from wells. Add 100 µl/well fresh 3.7% Formaldehyde in PBS. Incubate for 10 minutes at room temperature (RT). Flick out and add 100 µl/well 0.1% Triton-X 100. Incubate for 5 minutes at RT. Flick out and wash twice with PBS. Flick out PBS and add 100 µl/well blocking buffer (3% FBS in PBS). Incubate for 30 minutes at RT. Flick out and add diluted antibody (diluted in blocking buffer). Incubate for 1 hour at RT. Flick out and wash three times with PBS. Flick out and add second step reagent. Incubate for 1 hour at RT. Flick out and wash three times with PBS. Image sample.Suggested Companion ProductsNameCatalog Number Size Clone 353219BD Falcon™ 96-well Imaging Plate 1 plate(none) 611450Human Endothelial Cell Lysate500 µg(none) 554656Stain Buffer (FBS)500 ml(none) 554655Fixation Buffer100 ml(none) 558050Perm Buffer III125 ml(none) Product Notices1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.2.Please refer to /pharmingen/protocols for technical protocols.3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water beforediscarding to avoid accumulation of potentially explosive deposits in plumbing.4.Source of all serum proteins is from USDA inspected abattoirs located in the United States.ReferencesKu H, Meier KE. Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells. J Biol Chem. 2000;275(15):11333-11340.(Biology: Immunoprecipitation, Western blot)Leventhal PS, Feldman EL. Tyrosine phosphorylation and enhanced expression of paxillin during neuronal differentiation in vitro. J Biol Chem. 1996;271(11):5957-5960.(Biology)Salgia R, Li JL, Lo SH, et al. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J Biol Chem. 1995;270(10):5039-5047.(Biology)Takayama Y, Tanaka S, Nagai K, Okada M. Adenovirus-mediated overexpression of C-terminal Src kinase (Csk) in type I astrocytes interferes with cell spreading and attachment to fibronectin. Correlation with tyrosine phosphorylations of paxillin and FAK. J Biol Chem. 1999; 274(4):2291-2297.(Biology: Immunofluorescence, Immunoprecipitation, Western blot)Turner CE, Glenney JR Jr, Burridge K. Paxillin: a new vinculin-binding protein present in focal adhesions. J Cell Biol. 1990; 111(3):1059-1068.(Biology)。
血清转铁蛋白、尿液转铁蛋白、尿液视黄醇结合蛋白、胱抑素C_检测对糖尿病肾病的临床应用价值分析
DOI：10.16658/ki.1672-4062.2023.04.025血清转铁蛋白、尿液转铁蛋白、尿液视黄醇结合蛋白、胱抑素C检测对糖尿病肾病的临床应用价值分析袁金，陈琼，张雯福州市第八医院检验科，福建福州350000[摘要]目的分析血清转铁蛋白、尿液转铁蛋白、尿液视黄醇结合蛋白联合胱抑素C检测对糖尿病肾病诊断的应用价值。
方法选取2019年1月—2022年2月福州市第八医院治疗的60例糖尿病肾病患者为研究对象，依据患者的尿白蛋白排泄量/肌酐比值差异将其分为A组（22例，蛋白尿正常）、B组（21例，微量蛋白尿）、C 组（17例，大量蛋白尿），另选同期的20名体检健康者设为对照组。
所有患者均接受血清转铁蛋白、尿液转铁蛋白、尿液视黄醇结合蛋白联合胱抑素C检测，分析4组检测结果。
结果4组受检者血清转铁蛋白、尿液转铁蛋白、尿液视黄醇结合蛋白、胱抑素C检测结果比较，差异有统计学意义（F=538.653、10.125、197.153、416.223，P<0.05）。
结论血清转铁蛋白、尿液转铁蛋白、尿液视黄醇结合蛋白、胱抑素C检测对于糖尿病肾病患者有一定的参考价值。
[关键词] 血清转铁蛋白；尿液转铁蛋白；尿液视黄醇结合蛋白；胱抑素C；糖尿病肾病[中图分类号] R59 [文献标识码] A [文章编号] 1672-4062（2023）02（b）-0025-04Analysis of Serum Transferrin, Urine Transferrin, Urine Retinol-binding Protein, Cystatin C Clinical Application Value of Diabetes NephropathyYUAN Jin, CHEN Qiong, ZHANG WenDepartment of Clinical Laboratory, Fuzhou Eighth Hospital, Fuzhou, Fujian Province, 350000 China[Abstract] Objective To analyze the diagnostic value of serum transferrin, urine transferrin, urine retinol-binding protein combined with cystatin C in diabetic nephropathy. Methods 60 patients with diabetes nephropathy who were treated in Fuzhou Eighth Hospital from January 2019 to February 2022 were selected as the study subjects. According to the difference of urinary albumin excretion/creatinine ratio, the patients were divided into group A (22 cases, nor⁃mal proteinuria), group B (21 cases, microalbuminuria), and group C (17 cases, massive proteinuria), another 20 healthy individuals who underwent physical examination during the same period were selected as the control group. All patients received serum transferrin, urine transferrin, urine retinol-binding protein combined with cystatin C detec⁃tion. The test results were analyzed between the four groups. Results In the detection results of serum transferrin, urine transferrin, urine retinol binding protein, and cystatin C among the four groups of subjects, the difference was statistically significant (F=538.653, 10.125, 197.153, 416.223, P<0.05). Conclusion The detection of serum transfer⁃rin, urine transferrin, urinary retinol binding protein and cystatin C has certain reference value for patients with diabe⁃tes nephropathy.[Key words] Serum transferrin; Urine transferrin; Urine retinol-binding protein; Cystatin C; Diabetic nephropathy糖尿病肾病若未能及时诊治，一旦发展至终末期治疗的难度会显著提高[1]。
维莫非尼片说明书
核准日期：2017年3月10日修改日期：2017年5月26日2017年11月29日2018年7月24日2020年2月13日2021年2月26日2022年1月17日2022年2月22日维莫非尼片说明书请仔细阅读说明书并在医师指导下使用【药品名称】通用名：维莫非尼片商品名：佐博伏®,英文商品名Zelboraf®英文名：Vemurafenib film-coated tablets汉语拼音：Weimofeini Pian【成份】本品主要活性成分为维莫非尼，以维莫非尼和琥珀酸醋酸羟丙甲纤维素固体分散体存在。
化学名称：丙烷-1-磺酸{3-[5-(4-氯苯基)-1H- 吡咯并[2,3-b]吡啶-3-羰基]-2,4-二氟代苯基}- 酰胺。
化学结构式：分子式：C23H18ClF2N3O3S分子量：489.93【性状】两面凸起、粉白色至橙白色的薄膜衣片。
【适应症】佐博伏®适用于治疗经CFDA批准的检测方法确定的BRAF V600突变阳性的不可切除或转移性黑色素瘤。
【规格】240 mg【用法用量】患者必须经由CFDA批准的检测方法确定的证明肿瘤为BRAF V600突变阳性，才可使用佐博伏®治疗。
佐博伏®不能用于BRAF野生型黑色素瘤患者。
首剂药物应在上午服用，第二剂应在此后约12小时，即晚上服用。
每次服药均可随餐或空腹服用。
用一杯水送服药物，服药时整片吞下佐博伏®片剂。
不应咀嚼或碾碎佐博伏®片剂。
标准剂量佐博伏®的推荐剂量为960 mg（四片240 mg片剂），每日两次。
治疗持续时间建议佐博伏®治疗应持续至疾病进展或发生不可接受的毒性反应（参见表1和表2）。
漏服如果漏服一剂计划的药物，可在下一剂服药4小时以前补服漏服的药物，以维持每日两次的给药方案。
不应同时服用两剂药物。
呕吐如果佐博伏®服药后发生呕吐，患者不应追加剂量，而应按常规剂量继续治疗。
Ampicillin_69-53-4_DataSheet_MedChemExpress
Product Name:Ampicillin CAS No.:69-53-4Cat No :HY-B0522Product Data SheetCat. No.:HY B0522MWt:349.40Formula:C16H19N3O4S Purity :>98%Solubility:Mechanisms:Biological Activity:Pathways:Anti-infection; Target:Antibacterial DMSOAmpicillin is an orally active broad-spectrum antibiotic.Target: Antibacterial Ampicillin is an antibiotic useful for the treatment of a number of bacterial infections. It is a beta-lactam antibiotic that is part of the aminopenicillin family and is roughly equivalent to its successor,amoxicillin in terms of spectrum and level of activity. Belonging to the penicillin group of beta-lactam antibiotics, ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. It differs from penicillin G, or benzylpenicillin, only by the presence of an amino group. That amino group helps the drug penetrate the outer membrane of Gram-negative bacteria. Ampicillin acts as an irreversible inhibitor of the enzyme transpeptidase which is needed by bacteria to make their cell References:[1]. /wiki/Ampicillin irreversible inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. It inhibits the third and final stage of bacterial cell wall synthesis in binary fission...Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AE m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。
碧云天生物技术产品说明书.pdf_1693824582.1567516
碧云天生物技术/Beyotime Biotechnology订货热线：400-168-3301或800-8283301订货e-mail：******************技术咨询：*****************网址：碧云天网站微信公众号MONOMAC1 (人急性单核白血病细胞)产品编号产品名称包装C6604 MONOMAC1 (人急性单核白血病细胞) 1支/瓶产品简介：Organism Tissue Morphology Culture Properties Homo sapiens (Human) Peripheral blood Round Suspension本细胞株详细信息如下:General InformationCell Line Name MONOMAC1 (Human Acute Monocytic Leukemia Cells)Synonyms MONO-MAC-1; Mono Mac 1; Monomac-1; MonoMac1; Mono-Mac-1; MM1Organism Homo sapiens (Human)Tissue Peripheral bloodCell Type －Morphology RoundDisease －Strain －Biosafety Level* 1Age at Sampling 64 yearsGender MaleGenetics －Ethnicity －Applications －Category Cancer cell line* Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.CharacteristicsKaryotype －Virus Susceptibility －Derivation －Clinical Data －Antigen Expression －Receptor Expression －Oncogene －Genes Expressed －Gene expression databases ArrayExpress: E-MTAB-2770; E-MTAB-3610; GEO: GSM482510; GSM887337; GSM888413; GSM1670129Metastasis －Tumorigenic －Effects －Comments －Culture MethodDoubling Time 30~50 hrsMethods for Passages Split cells to new flask with fresh medium. No need to treat them enzymatically to detach them from the surface of the culture vessel.Medium 90% RPMI 1640+10% h.i. FBS+2mM L-glutamine+1x non-essential amino acids+1mM sodium pyruvateSpecial Remarks －Medium Renewal －Subcultivation Ratio －Growth Condition 95% air+ 5% CO2, 37ºCFreeze medium DMEM (high glucose)+20% FBS+10% DMSO，也可以订购碧云天的细胞冻存液(C0210)。