gas5
大体评定量表(GAS)

(如有时前后不连贯或没有应答)或判断(如如 其行为极不适合)之中。
11-20,需要某些监督管理,才能防止其自杀
或伤人;或不能维持起码的个人卫生(如反复 的自杀行为、频繁的暴力表现、躁狂性激动、 把粪便丢得一塌糊涂等)或者有交谈方面的严 重(如如重度不连贯或缄默)。
1-10,需要好多天持续不断的监督管理,才
统计指标
GAS只有一项变量,即量表 分,根据此分进行统计分析。
应用评定
1.GAS在经过训练后,可取得相当高的 评分员一致性。在一次全国性量表讲习班上 40 名评分员,对 8 例患者作 GAS 评定,统计 10 分大级的符合率为 88% ,各评定员评分一 致性相当高, Kapa=0.30 ~ 0.89 ,多数在为 0.70 以上,说明 GAS 信度良好。 GAS 效度相 当高,国外曾比较33例抑郁患者的病情严重 程度(11级评分)与 GAS评定,r=0.80。
91-100,指在各方面都有较高的活动能力。
日常生活上的问题,从未有无法处理的情形; 由于其热情和正直,别人都愿与其相处,没 有症状。
81-90,在所有领域中都能良好活动,兴趣
和社交好。一般而言对生活是满意的,至多 也只有暂时性的症状发生,“日常的”担忧 偶尔无法处理。
71-80,至多也只是对于活动能力有轻
2.先按病情评出其大范围的等级,即是31~40, 还是41~50。然后,再根据具体病情,评定在这一等 级中偏重还是偏轻,给予具体评分,例如大类是31~ 40,病情在这一等级中偏重,则应评为32或33分。
3.GAS的评定需要相当的临床经验, 因而一般由精神科医师,而且是主治该病人 的医师作评定员。
姚树桥 教授
长链非编码RNA在多发性硬化发病机制中的研究进展

长链非编码RNA在多发性硬化发病机制中的研究进展①巩盼盼柳宁武世萍俞坤王满侠(兰州大学第二医院神经内科,兰州730000)中图分类号R741 文献标志码 A 文章编号1000-484X(2023)09-1993-05[摘要]多发性硬化(MS)作为一种常见的中枢神经系统炎症脱髓鞘疾病,其发病机制研究尚不清楚。
目前长链非编码RNA(lncRNA)虽无蛋白质编码功能,但它在疾病的免疫调节中发挥重要作用。
近年来,在MS患者及实验性自身免疫性脑脊髓炎(EAE)动物模型中发现了大量异常表达的lncRNA。
在本文中,将MS及EAE模型中涉及的lncRNA作一简单小结,着重讨论lncRNA在MS发病机制中的研究现状。
[关键词]长链非编码RNA;多发性硬化;实验性自身免疫性脑脊髓炎;免疫细胞Research progress of long non-coding RNA in pathogenesis of multiple sclerosis GONG Panpan, LIU Ning, WU Shiping, YU Kun, WANG Manxia. Department of Neurology, Lanzhou University Second Hospital, Lanzhou 730000, China[Abstract]Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system, specific pathogen‐esis of which is still unclear. Long chain non-coding RNA(lncRNA) without protein coding function, which were found in playing im‐portant functions in many diseases. In recent years, some patients with MS and animal model of experimental autoimmune encephalo‐myelitis (EAE) were discovered that expressed a large number of abnormal lncRNA. In this paper, lncRNA involved in MS and EAE models are summarized briefly, focusing on the current research status of lncRNA in the pathogenesis of MS.[Key words]Long non-coding RNA;Multiple sclerosis;Experimental autoimmune encephalomyelitis;Immune cell多发性硬化(multiple sclerosis,MS)是一种慢性中枢神经系统的自身免疫性疾病。
利雅路燃烧器说明书

2915915 (0)CODEMODELTYPE3751917 - 3751918GAS 3519 T13751617GAS 4516 T13751717GAS 5517 T13751817GAS 6518 T1GAS安装、使用以及维护说明书燃气燃烧器GAS 3-4-5-6目录技术参数-------------------------------------------------------2附件----------------------------------------------------------------3燃烧器描述----------------------------------------------------------4包装重量------------------------------------------------------------4最大尺寸------------------------------------------------------------4标准配件------------------------------------------------------------4燃烧出力------------------------------------------------------------5商业锅炉------------------------------------------------------------5测试锅炉------------------------------------------------------------6燃气压力------------------------------------------------------------6安装-----------------------------------------------------------7锅炉板--------------------------------------------------------------7燃烧头的长度--------------------------------------------------------7燃烧器固定在锅炉上--------------------------------------------------7燃烧头的设置--------------------------------------------------------8燃气管线------------------------------------------------------------9电气系统-----------------------------------------------------------10首次点火前的调整---------------------------------------------------13燃烧器启动---------------------------------------------------------13燃烧器点火---------------------------------------------------------13燃烧器校准---------------------------------------------------------141.点火输出功率--------------------------------------------------142.最大输出功率--------------------------------------------------153.空气压力开关--------------------------------------------------154.最低燃气压力开关----------------------------------------------15火焰状况检查-------------------------------------------------------15燃烧器运行---------------------------------------------------------16最终检查-----------------------------------------------------------17维护保养-----------------------------------------------------------17故障表-----------------------------------------------------18 燃烧器启动循环诊断-----------------------------------------20运行故障诊断--------------------------------------------------------201技术参数型号GAS3 GAS4 GAS5 GAS6类型519T1 516T1 517T1 518T1出力KW 130-350 185-465 325-660 525-1050 Mcal/h 112-301 160-400 280-570 450-900燃料天然气:G20-G21-G22-G23-G25G20 G25 G20 G25 G20 G25 G20 G25热值kwh/Nm3 10 8.6 10 8.6 10 8.6 10 8.6Mcal/Nm38.6 7.4 8.6 7.4 8.6 7.4 8.6 7.4比重kg/Nm30.71 0.78 0.71 0.78 0.71 0.78 0.71 0.78最大出力Nm3/h 35 43 47 54 66 77 105 122 最大压力mbar 11.1 16.4 9.8 14.5 9.8 14.5 12.3 18.2运行—间断工作(每24小时停一次)—1段火工作标准应用锅炉:热水、蒸汽、导热油炉环境温度℃ 0-40助燃空气℃max 60V 230~+/-10% 230-400(带零线)~+/-10% 电源Hz 50-单相 50-三相rpm 2750 2810 2870 2840kW 0.250 0.370 0.750 1.5V 220 220 220/380 220/380240 240 240/415 240/415 电机A 1.8 2.9 2.85-1.65 5.9-3.4μF 8 12.5电容V 450/500 400/450点火变压器V1-V2I1-I2 230V-1×8kV 1.8A-30mA电耗kW max 0.4 0.54 0.85 1.7电保护 IP40电磁干扰符合90/396-89/336-73/23-92/42审核标准CE 0085AQ0707(1)参考条件:环境温度20℃,大气压力为100mbar(2)测试点12)(A)p.4处的压力,燃烧室压力为零,燃气环2)(B)p.8开启,燃烧器输出功率最大重要提示:由安装者负责其它不在此说明书中提到的安全设备。
IncRNA系列:lncRNA的生物学功能(二)

IncRNA系列:lncRNA的⽣物学功能(⼆) 有研究报道,lncRNA可以通过调节细胞周期和凋亡的⽅式,来影响细胞的增殖。
例如,Gas5(growth arrest-specific 5,⾮编码RNA)在细胞周期阻滞的细胞内⼤量集聚。
其发挥作⽤的机制是抑制对于糖⽪质激素敏感的基因表达,使得细胞发⽣凋亡。
Gas5能与糖⽪质激素受体上的“糖⽪质激素反应元件”(glucocorticoid response element,GRE,该反应元件位于糖⽪质激素受体的DNA结合结构域内)相结合,通过竞争性抑制的⽅式抑制由糖⽪质激素受体诱导的DNA转录反应。
第⼆个例⼦是lincRNA-p21(Long intergenic non-coding RNA-p21)。
该分⼦由p53激活并在p53信号通路中发挥重要作⽤并诱导细胞凋亡。
lincRNA-p21和hnRNP-K(heterogenous nuclear ribonucleoprotein-K)相互结合,并介导下游hnRNP-K的转录抑制作⽤。
第三个被详细研究的分⼦是lncRNA PANDA。
lncRNA PANDA 位于CDKN1A基因转录起始位点上游5kb处,它的序列正好和CDKN1A 的序列互补。
它在DNA损伤引起的反应中发挥了重要的作⽤。
在DNA发挥损伤后,p53激活了CDKN1A、PANDA和lincRNA-p21的转录。
PANDA被转录后,和转录因⼦NF-YA相互结合并抑制凋亡。
PANDA、lincRNA-p21和CDNK1A这三个基因协同作⽤,最终影响了细胞周期阻滞和细胞凋亡。
(⼆)lncRNA 对于mRNA降解的调控作⽤ mRNA 在细胞内的丰度往往决定了蛋⽩表达的⾼低(虽然不绝对,但是⼤多数情况下如此)。
⽽mRNA 在细胞内的丰度,通常有两个⽅⾯的原因决定:1)转录的多少;2)降解的快慢。
其中,mRNA的降解有多条途径,⽽lncRNA则参与了其中Staufen 1 介导的mRNA降解途径(Staufen 1-mediated mRNA decay,SMD)。
内科领域的英文单词

内科abdomen /5Abd/m/n/腹部accommodation reflex //kRm/5deiF(/)n 5ri:fleks/调节反射acutc appendicitis //5kju:t 7/pendi5saitis/急性兰尾炎acute myocardial infaction //5kju:t /急性心肌梗塞acute peritionitis //5kju:t /急性腹膜炎anemia //5ni:mi//贫血aortic insufficiency / 7ins/5fiF/nsi/主动脉瓣关闭不全aortic valve stenosis / vAlv /主动脉狭窄apical belly /5eipik(/)l 5beli/尖腹apical four chamber view /5eipik(/)l fR:(r) 5tFeimb/(r) vju:/心尖四腔图apical inpulse /5eipik(/) /心尖搏动appendicitis /7/pendi5saitis/阑尾炎arrhythmia //5riTmi// 心律失常articulatio //关节ascites //5saiti:z/腹水atrial flutter / 5flQt/(r)/心房扑动audation //听力auricle /5R:rik(/)l/耳廓auscultation /R:skul5teiF(/)n/听诊barrel chest /5bAr(/)l 5tFest/桶状胸blood pressure /blQd 5preF/(r)/血压blood vessel /blQd 5ves(/)l/血管board-like rigidity / -laik ri5dVid/ti/板状腹bronchial breath sound /5brRNki/l breW 5s/und/支气管呼吸音bronchophony //支气管语音bronchovesicular breath sound / breW 5s/und/支气管肺泡呼吸音bundle branch block /5bQnd(/)l bra:ntF blRk/束支阻滞cachexia /k/5keksi//恶液质cadiac asthma / 5Asm/ (5Azm/)/心源性哮喘cardiac auscultation /5ka:diAk 7R:skul5teiF(/)n/心脏听诊cardiac dilatation /5ka:diAk 7dail/5teiF/n/心脏扩大cardiac souffle /5ka:diAk 5su:fl/心脏杂音cardiologist //心脏病学家cheat discomfort /tFi:t dis5kQmf/t/胸部不适chief complaint /5tFi:f k/m5pleint/主诉childbearing history /5tFaildbe/riN 5hist/ri/生育史circulation system physical diagnostic /s\:kju5leiF(/)n 5sist/m 5fizik(/)l dai/g5nRstik/循环系统的物诊学cirrhosis of liver /si5r/usis 5liv/(r)/肝硬变clinician /kli5niF/n/临床家colonosopy //肠镜concentric stenosis /k/n5setrik /中心狭窄conduction system /k/n5dQkF(/)n 5sist/m/传导系统conjunctiva /k/n5dVQNktaiv//结膜continus fever / 5fi:v/(r)/稽留热convergence reflex /k/n5v\:dV/ns 5ri:fleks/幅奏反射cough /kRf (kR:f)/咳嗽cyanosis /7sai/5n/usis/紫绀dappler /5dAp(/)l//多普勒depolarization //除级diagnosis /7dai/g5n/usis/诊断diffusion capacity /di5fju:V(/)n k/5pAsiti/弥散量dilated congestive cardiomyopathy /dai5leitid(i) k/n5dVestiv 7ka:di/umai5Rp/Wi /扩张性心肌病dullness /5dQlnis/浊音duodenal ulcer /7dju:/u5di:n/l 5Qls/(r)/十二指肠溃疡dyspnea //呼吸困难dyspnea /disp'niE/呼吸困难dysuria /dis5ju/ri//尿痛ear drum /i/(r) drQm/鼓膜eccentric stenosis /ik5sentrik /偏心狭窄echocardiography /ek/u7ka:di5Rgr/fi/超声心动图ejection sounds /i5dVekF/n saund/喷射音electrocardiogram /i7lektr/u5ka:di/ugrAm/心电图endogenous pyrogen /en5dRdVin/s 5pai/r/udVin/内源性致热源endoscopic polypectomy /7end/5skRpik 7pRli5pekt/mi/内镜下息肉切除术endoscopic retrograde cholangio–pancreatography ERCP /7end/5skRpik 5retr/greit - /内镜下逆行胰胆管造影endoscopic ultrasonograohy /7end/5skRpik /内镜超声endoscopy //内镜endoscpic sphincterotomy EST / /内镜下乳头肌切开术epistaxis /7epi5stAksis/鼻衄esophagoscopy /i:sRf/5gRsk/pi/食道镜expectoration /ek7spekt/5reiF/n/咳痰eyelids /5ailid/眼睑family history /5fAmili 5hist/ri/家族史first sound(S1)/f\:st saund/ 第一心fixed splitting of S2 /fikst 5splitiN/第二心音固定分裂flatness //实音floating patella phenomenon /5fl/utiN p/5tel/ fi5nRmin/n(nRn)/浮髌现象fluctuation // 波动感fluid thrill /5flu:id 5Wril/液波震颤forced vital capacity /fR:st k/5pAsiti/周力肺活量frequent micturition /5fri:kw/nt 7mikju/5riF(/)n/尿频frog belly /5frRg (5frR:g) 5beli/蛙腹gas exchange /gAs iks5tFeindV/气体交换gastric ulcer / 5Qls/(r)/胃溃疡gastroscopy /7gAs5trRsk/pi/胃镜general data /5dVen/r(/)l 5deit/ (5dAt/)/一般项目general data /5dVen/r(/)l 5deit/ (5da:t/) (5dAt/)/一般项目gurgling sound /5g\:g(/)liN 5s/und/肠鸣音heart auscultation /ha:t 7R:skul5teiF(/)n/心脏听诊heart faailure /ha:t /心力衰竭heart inspection /ha:t in5spekF(/)n/心脏视诊heart murmurs /ha:t 5m\:m/(r)/心脏杂音heart palpation /ha:t 5pAlpeiF/n/心脏触诊heart percussion /ha:t p/5kQF(/)n/心脏扣诊heart sound /ha:t saund/心音hemoptysis /hi5mRptisis/咳血hepatic coma /hi5pAtik 5k/um//肝昏迷Heyne-Stokes respiration / -st/uk/呼吸His bundle /his 5bQnd(/)l/希氏束history of present illness /5hist/ri 5prez(/)nt 5ilnis/现病史holosystolic murmurs / 5m\:m/(r)/全收缩期杂音hypoventilation //低通气hypercapnia /7haip/5kApni//高碳酸血症hyperresonance //过清音hypertension /7haip/5tenF/n/高血压hyperthyresis //甲亢hyperventilation /7haip/venti5leiF(/)n/高通气hypocania //低碳酸血症hypoxin //低氧血症incontinence of urine /in5kRntin/ns 5ju/rin/尿失禁inquisition /inkwi5ziF(/)n/问诊inspection /in5spekF(/)n/视诊intermittent fever /int/5mit/nt 5fi:v/(r)/间歇热intestinal obstruction /in5testin/l /b5strQkF/n/肠梗阻jugular venous pulse /5dVQgjul/(r) 5vi:n/s pQls/颈静脉搏动Kussmaul respiration //呼吸lead /li:d/导联left ventricular long axis view /left ven5trikjul/(r) lR(R:)N 5Aksis vju:/左室长轴切left ventricular stort axis view /left ven5trikjul/(r) /左室短轴切面liver biopsy /5liv/(r) 5baiRpsi/肝穿刺liver cirrhosis /5liv/(r) si5r/usis/肝硬化liver palms /5liv/(r) pa:m/肝掌lung function testing /lQN 5fQNk(/)n 5testiN/肺功能测定lung volume /lQN 5vRlju:m/肺音lymph node /limf n/ud/淋巴结marital history /'mAritEl 5hist/ri/婚姻史mastoid /5mAstRid/乳突Mc Burney //麦氏点melena /m/5li:n//黑便menstrual history /5menstru/l 5hist/ri/月经史metabolic alcaldosis / /代碱metabolic acidosis /7met/5bRlik 9Asi'dEusis/代酸mitral insufficiency /5maitr/l 7ins/5fiF/nsi/二尖瓣关闭不全mitral stenosis /5maitr/l /二尖瓣狭窄mitral valve stenosis /5maitr/l vAlv /二尖瓣狭窄moist rale /5mRist /湿罗音Murphy /5m\:fi/莫非氏征musculature of the arterotes /5mdskuul/tF/(r) /动脉心肌图组织myocardial infarction / in5fa:kF/n/心肌梗塞myocardial ischemia / /心肌缺血myocardium /9maiE'ka:diEm/心肌neurogenic bladder /7nju/r/u5dVenik 5blAd/(r)/神经元性膀胱opening snap /5/up/niN snAp/开瓣音pacemaker /5peismeik/(r)/起搏器palpation /5pAlpeit/触诊parotid gland /pe5rRtid 5glAnd/腮腺paroxysmal supraventricular tachycardia /7pAr/k5sizm/l 7tAki5ka:di//阵发性室上性心动过速peptic ulcer /5peptik 5Qls/(r)/消化性溃疡percussion /p/5kQF(/)n/叩诊pericardial effusion /7peri5ka:di/l i5fju:V(/)n/心包积液pericardial friction rubs /7peri5ka:di/ 5frikF(/)n rQb/心包摩擦音peristalsis /peri5stAksis/蠕动波perpheral arteral Vessels / 5ves(/)l/周围动脉血管personai history / 5hist/ri/个人史pleural friction fremitus / 5frikF(/)n 5fremit/s/胸膜磨擦感pneumoperitoneum // 气腹portal hypertension /5pR:t(/)l 7haip/5tenF/n/门脉高压症preexcitation syndrome / 5sindr/um(dr/m)/激综合征premature beat(extrasystole)/5prem/tFu/(r) (pri:m/5tu/r) bi:t (7ekstr/5sist/li)/过早搏动pulmonary hypertension /5pQlm/n/ri 7haip/5tenF/n/ 肺动脉高压pulse /pQls/脉搏radiofrequency catheter ablation / 5kAWit/(r) Ab5leiF/n/导管射频消融术rebound tenderness /5ri:b/und /反跳痛recurrent fever /ri5kQr/nt 5fi:v/(r)/回归热refractory period /ri5frAkt/ri 5pi/ri/d/不应期remittent fever /ri5mit(/)nt 5fi:v/(r)/驰张热repolarization //复级resonance /5rez/n/ns/清音retention of urine /ri5tenF(/)n 5ju/rin/尿潴留rib /rib/肋骨S3. S4 gallop rhythm /5gAl/p riT(W)m/第三心音第四心音奔马律scaphoid abdomen /5skAfRid 5Abd/m/n/舟状腹scapular line /5skApjul/(r) lain/肩胛线second sound(S2)/5sek/nd saund/第二心音setpoint //调定点shifting dullness / 5dQlnis/移动性浊音sign /sain/体征sinus arrest /5sain/s /5rest/窦性停搏Spider /5spaid/(r)/ 蜘蛛痣spider /5spaid/(r)/蜘蛛痣sternal angle / 5ANg(/)l/胸骨角stethoscope /5steW/sk/up/听诊器succussion splash / splAF/振水音symptom /5simpt/m/症状syncope /5siNk/pi/晕厥systems review /5sist/m ri5vju:/ 系统回顾systolic click /si5stRlik klik/收缩期喀喇音tactile fremitus /5tAktail 5fremit/s/触觉震颤tenderness //压痛three depressions sign /Wri: di5preF(/)n sain/三凹征transesophageal atrial pacing / peisi/经食管心房调搏Traube //胃泡鼓音区treadmill test /5tredmil test/活动平板试验tricuspid regurgitation /trai5kQspid ri7g\:dVi5teiF/n/三尖瓣反流two dimension /tu: di5menF(/)n/二维tympany //鼓音umbilicus /Qm5bilik/s/脐部undulant fever / 5fi:v/(r)/波状热urgent micturition /5\:dV/nt 7mikju/5riF(/)n/尿急venous to arterial shunts /5vi:n/s a:5ti/ri/l FQnt/ A-V分流ventricular fibrillation /ven5trikjul/(r) 7faibri5leiF/n/心室颤动vesicular breath sound /vi5sikjul/(r) breW 5s/und/肺泡呼吸音vital capacity /'vaitEl k/5pAsiti/肺活量Wenckebach phenomenon / fi5nRmin/n (nRn)/文氏现象wheeze /wi:z (hwi:z)/喘鸣音影像医学常用专业英语单词及词汇air bronchogram /e/(r) 5brRNk/ugrAm/支气管气像angiography /7AndVi5Cgr/fi/血管造影atrial impression of esophagus /5a:tri/l im5preF(/)n i:5sCf/g/s/心房食管压迹bronchiectasis /7brCNki5ekt/sis/支扩catheter /kA5Wit/(r)/导管cavernous hemangioma /5kAv/n/s hi7mAndVi5/um//海绵状血管瘤computed tomography /k/m5pju:t t/5mCgr/fi/计算机体层摄影CT consolidation /k/n7sCli5deiF/n/实变contrast enhancement /k/n5tra:(trA)st in5ha:nsm/nt/造影增强扫描contrast media /k/n5tra:(5trA)st 5mi:di//造影剂crater /5kreit/(r)/龛影degenerative osteoarthropathy /di5dVen/r/tiv 7Rsti/ua:W5rRp/Wi/退行性骨关节炎destruction of bone /di5strQkF(/)n b/un/骨质破坏diaphysis /dai5Afisis/骨干digital radiography /5didVit(/)l 7reidi5Cgr/fi/数字X线成像 (DR) emphysema /7emfi5si:m//肺气肿epiphysis /i5pifisis/骨骺filling defect /5filiN di5fekt/充盈缺损hilar shadow /5hail/(r) 5FAd/u/肺门影injury of skull /5indV/ri skQl/颅脑外伤intervertebral disc /7int/5v\:tibr/l disk/椎间盘intravenous pyelography /7intr/5vi:n/s 7pai/5lCgr/fi/静脉肾盂造影IVPirritation /7iri5teiF(/)n/激惹lacunar infarct /l/5kju:n/(r) in5fa:kt/腔隙性脑梗塞linitis plastica //皮革胃liver abscess /5liv/(r) 5Absis/肝脓肿lung field /lQN fi:ld/肺野lung marking /lQN 5ma:kiN/肺纹理magnetic resonance image /mAg5netik 5rez/n/ns 5imidV/核磁共振成像MRImediastinum /7mi:diAs5tain/m/纵隔meniscus sign /mi5nisk/s sain/半月征metaphysis //骺端obstructive atelectasis //b5strQktiv 7At/5lekt/sis/阻塞性肺不张osteoporosis /7Csti/up/5r/usis/骨质疏松osteosarcoma /7Rsti/usa:5k/um//骨肉瘤percutaneous transhepatic cholangiography /7p\:kju:5teini/s trAnshi5pAtik k/7lAndVi5Cgr/fi/经皮肝穿胆道造影( PTC ) picture archiving communication system /5piktF/(r) 5a:kaiviN 7k/mju:ni5keiF(/)n 5sist/m/图像存档与传输系统( PACS ) pleural effusion /5plu/r/l i5fju:V(/)n/胸腔积液pneumonia /nju:( nu:)5m/uni//肺炎pneumoperitoneum /7nju:m/u7peri5t/uni/m/气腹pneumothorax /7nju:m/u5WC:rAks/气胸pulmonary edema /5pQlm/n/ri(neri) i5di:m//肺水肿pulmonary hypertension /5pQlm/n/ri 7haip/5tenF/n/肺动脉高压rheumatic heart disease /ru:5mAtik ha:t di5zi:z/风心sequestrum /si5kwestr/m/死骨soap-bubble appearance /5s/up-5bQb(/)l /5pi/r/ns/肥皂泡样改变spatial resolution /5speiF(/)l 7rez/5lu:F(/)n/空间分辨力stenosis of spinal canal /sti5n/usis 5spain(/)l k/5nAl/椎管狭窄stent //支架sub-periosteal reaction /sQb-7peri5Rsti/l ri:5AkF(/)n/骨膜反应其它Hemolytic streptococcus甲族乙型溶血性链球菌Antithymocyte globulin (ATG)抗胸腺细胞球蛋白Vagus nerve迷走神经,Brainstem death脑干死亡Brain death脑死亡Myocardial remodeling心肌重塑Hemodynamics血液动力学Atrial natriuretic factor (ANF)心钠素Vasopressin血管加压素,抗利尿激素Bradykinin缓激肽Triggered activity触发活动Afterdepolarization后除极Late ventricular potential心室晚电位Sinus node recovery time(SNRT)窦房结恢复时间Sinoatrial conduction time(SACT)窦房传导时间Intrinsic heart rate固有心率Accessory atrioventricular pathways房室旁路Atriohisian tracts房希氏束Nodoventricular fibers结-室纤维Fasciculoventricular fibers分支室纤维Insulin resistance胰岛素抵抗Vasodepressor response血管减压反应Pulsus tardus细迟脉Minimum Inhibitory concentration (MIC)最小抑菌浓度Systolic anterior motion(SAM)(二尖瓣前叶)收缩期前向运动Intermittent claudication间歇性跛行Tachycardia心动过速Sinus tachycardia窦性心动过速心力衰竭:Heart failure心力衰竭Congestive beart failure充血性心力衰竭Acute left-sided heart failure急性左心衰竭Chroinc heart failure慢性心力衰竭Intractable heart failure难治性心力衰竭Systolic insufficiency heart failure收缩功能不全性心力衰竭Diastolic insufficiency heart failure舒张功能不全性心力衰竭Congestive heart failure充血性心力衰竭Cardiac dysfunction心功能障碍心律失常:Arrhythmia(cardiac arrhythmia)心律失常Triggered activity触发活动Afterdepolarization后除极窦房结Sinus node recovery time SNRT窦房结恢复时间Sinoatrial conduction time SACT窦房传导时间Bradycardia心动过缓药物Vasodilator血管扩张剂(phlebectasis静脉扩张,arteriectasis动脉扩张)Diuretic利尿剂(thiazide diuretic噻嗪类利尿剂;loop diuretic袢利尿剂;potassium-sparing diuretics保钾利尿剂)inotropic agent正性肌力药(digitalis preparation洋地黄制剂;adrenergic receptor stimulant肾上腺素能受体兴奋剂;phosphodiesterase inhibitor磷酸二酯酶抑制剂)Angiotensin converting enzyme inhibitor(ACE inhibitors)(ACEI)血管紧张素转换酶抑制剂Aldosterone antagonist醛固酮拮抗剂Beta adrenergic receptor blocker(beta blockers)呱錾舷偎啬苁芴遄柚图Calcium channel blocker(CCB)钙通道阻滞剂AngiotensionⅡantagonist(AngiotensionⅡreceptor blocker)血管紧张素Ⅱ受体阻滞剂Alpha blockersα1受体阻滞剂Nitroglycerin硝酸甘油Digoxin地高辛Lanatoside C西地兰antiarrhythic drugs抗心律失常药lidocaine利多卡因Propafenone普罗帕酮Amiodarone胺碘酮调脂药降脂药HMG-CoA reductase inhibitors HMG-CoA还原酶抑制剂Nicotinic acid烟酸Clofibrate氯贝丁酯recombinant tissue type plasminogen activator ,rt-PA重组组织型纤维蛋白酶原激活剂抗凝药操作interventional therapy for cardiovascular diseases心血管病介入性治疗Holter ECG monitoring动态心电图Ultrasound angioplasty超声消融术Directional coronary atherectomy定向旋切术High frequency rotational atherectomy高频旋磨术Laser angioplasty激光血管成形术Catheter ablation心导管消融Radiofrequency catheter ablation经导管射频消融Percutaneous balloon mitral valvuloplasty(PBMV)经皮穿刺球囊二尖瓣成形术Percutaneous balloon pulmonic valvuloplasty(PBPV)经皮穿刺球囊肺动脉瓣成形术Percutaneous transluminal septial myocardial ablation,(PTSMA)经皮经腔间隔心肌消融术Percutaneous transluminal coronary angioplasty (PTCA)经皮穿刺腔内冠状动脉成形术Percutaneous intracoronary stent implantation经皮穿刺冠状动脉内支架安置术Transluminal Extraction catheter (TEC)经皮血管内切吸导管Artificial cardiac pacing人工心脏起搏Multisite cardiac pacing多部位心脏起搏Biatrial pacing双心房起搏biventricular pacing双心室起搏bifocal pacing双灶起搏Heart transplantation心脏移植Angiojet rheolytic thrombectomy新鲜血栓吸引术Upright tilt-table testing直立倾斜试验Implantable cardioverter defibrillator (ICD)置入型心律转复除颤器Thumpversion捶击复律Cough-version咳嗽复律Cardioversion心脏电复律Defibrillation心脏电除颤Revascularization血管重建。
微型气体探测器5: GasAlertMicro 5说明书

Multilingual support in English, French, German, Spanish and Portuguese. Large LCD display with user-selectable backlight. Four alert levels: low, high, TWA and STEL stealth modes. prehensive self-test confirms sensor, battery and circuit integrity, plus audible/visual alarms when activated.Protection where you need it.Features and benefits. Monitoring of volatile organic compounds (VOC), H2S, CO, O2, SO2, PH3, CI2, NH3, NO2, HCN, CIO2, O3 and flammable substances.
最新:非编码RNA在心血管疾病中的研究进展

最新:非编码RNA在心血管疾病中的研究进展摘要心血管疾病是导致全球人类死亡的主要原因。
研究发现非编码RNA在心血管疾病中发挥了重要作用,不仅具有成为心血管疾病诊断特异性生物标志物的潜力,而且有望成为治疗的靶点。
因此现对非编码RNA在心血管疾病发病中的诊断价值及调控作用的研究进展进行综述,为心血管疾病的诊断及治疗提供新的思路。
关键词非编码RNA;心血管疾病;生物标志物心血管疾病(cardiovascu1ardisease,CVD)是全球导致人类死亡的主要原因之一,预后极差,每年死于CVD的人数约1.7亿[1]0其致病机制目前尚未完全阐明,心肌细胞的坏死、凋亡、增生、纤维化等因素参与了CVD的发病过程[2],而且各种危险因素(重症感染、糖尿病、高血压等)以及分子信号通路的互相作用构成了CVD的复杂性[3]o随着测序技术的成熟与推广,非编码RNA被发现在血液循环中稳定表达,不仅在心血管疾病中差异表达,而且发挥了重要的调控作用[4]o其中,微小RNA(miRNA)长度为18-25个核甘酸,以碱基互补配对的形式结合靶基因3,∪TR端,降解靶基因或抑制靶基因mRNA的翻译,在转录后水平调控基因表达[5]o一个成熟的miRNA可以靶向1个或多个基因,而1个基因可以被多种miRNA靶向,从而形成复杂的调控网络[5]o长链非编码RNA(IncRNA胀度>200个核苗酸,通过碱基互补配对原则与RNA或DNA发生特异性结合,在转录、转录后水平以及表观遗传学水平调控细胞的增殖、凋亡等功能[6]o环状RNA(CircRNA)是一种单链RNA,由外显子转录而来的共价闭环结构,可作为miRNA海绵,通过持有RNA结合蛋白以及控制选择性剪接和亲本基因的表达[7],在转录和转录后水平发挥调控作用。
非编码RNA的出现为CVD研究提供了全新的视角。
现就非编码RNA在CVD的诊断价值及调控作用的研究进展进行综述,以期为临床诊断及治疗提供新的思路。
长链非编码RNA-GAS5的功能与作用机制

长链非编码RNA-GAS5的功能与作用机制朱文彦;李响【期刊名称】《内江科技》【年(卷),期】2017(038)012【总页数】2页(P145-146)【作者】朱文彦;李响【作者单位】陆军军医大学大坪医院肿瘤中心;重庆医科大学第一附属医院心内科【正文语种】中文长链非编码RNA(long noncoding RNA, lncRNA)是近年来新发现的一类长度大于200nt的转录产物。
因其不具备编码功能性蛋白质的能力或者仅编码短的非功能多肽,故最初被认为是不具备生物学功能的转录副产物。
但近年来越来越多的研究表明,lncRNA广泛参与了生理和疾病的过程。
生长阻滞特异转录物5(growth arrest-specific transcript 5,GAS5),作为一种含有5'-TOP (5'-terminal oligopyrimidine tract)的长链非编码RNA,近年来被发现在哺乳动物细胞的生长和凋亡过程中起了关键的调控作用 [1]。
为能够向GAS5功能和作用机制的进一步研究提供线索,我们对GAS5的部分功能和作用机制进行综述。
GAS5最早是在在具有高度增殖活性的小鼠NIH 3T3细胞系中鉴定出来的,且在增殖活跃的NIH 3T3细胞和Friend leukemia细胞中GAS5表达量很低。
但当细胞营养缺乏时,其表达量升高[2],预示GAS5可能与细胞的生长状态有关。
Mourtada-Maarabouni等人 [3]在原代培养的人T淋巴细胞和CEM-C7细胞系中敲低内源性GAS5的表达,发现细胞正常状态下应该出现的生长停滞效应明显减弱,而血清饥饿或者地塞米松处理后的细胞本应受到抑制的克隆形成能力却依然存在。
结果预示,至少在人T细胞系中,正常的生长停滞效应依赖于GAS5的内源性表达。
mTOR是一种丝氨酸/苏氨酸蛋白激酶,被证实是调控细胞生长、分化、翻译、周期进程等多种生理功能的信号汇聚点。
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Modelling leakages in distribution networks encounters some specific problems. The first issue is the lack of sufficient information on exit points. The distribution networks have a vast number of exit points to the domestic sector, supplied with diaphragm gas metres which fail to provide the operator with any real-time data.
Ó 2012 Elsevier Ltd. All rights reserved.
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1. Introduction
Operators of natural gas networks relatively often have to deal with pipeline failures, leading to various-scale gas leakages. Once the pipeline integrity is restored, the network operator should also quantify the gas release, which is essential for economic, environmental and operational reasons. The quantity of the released gas may also be a subject of a controversy if the operator claims its compensation from a third party responsable for the failure. Moreover, in some cases it is required to estimate in advance gas releases from potential failures, as a part of quantitative risk assessment procedures [1]. However, the leakage quantification is generally a complex and frequently ill-defined task. In order to quantify the leakage, operators may choose various modelling approaches, depending on the type of network and on the availability of measurement data. As demonstrated in the paper, the choice of the flow model as well as the value of the discharge coefficient are of high relevance to these procedures and, eventually, to the leakage quantification result.
Furthermore, distribution networks have a complex, branched and/or looped structure without flow metering at splits and junctions. It is therefore generally not possible to limit the flow problem to a single pipeline and the network has to be modelled as a whole system.
* Corresponding author. Tel.: þ48 32 237 1661; fax: þ48 32 237 2872. E-mail address: wojciech.kostowski@polsl.pl (W.J. Kostowski).
0360-5442/$ e see front matter Ó 2012 Elsevier Ltd. All rights reserved. doi:10.1016/j.energy.2012.02.076
abstract
The paper discusses chosen issues concerning damaged gas pipelines. Attention is paid to modelling the steady-state flow of natural gas in distribution pipelines, and the most commonly applied models of isothermal and adiabatic flow are evaluated for both the ideal and the real gas properties. A method of accounting for a leakage by means of a reference flow equation with a discharge coefficient is presented, and the dependency of the discharge coefficient on pressure is demonstrated both with literature data and the authors’ experimental results. A relevant computational study of a pipeline failure is presented for a high- and a medium pressure pipeline. The importance of an appropriate choice of the flow model (isothermal or adiabatic flow of real or ideal gas) is demonstrated by the results of the study. It is shown that accounting for the variability of the discharge coefficient is required if medium pressure pipelines are analysed. However, it is eventually shown that the impact of the discharge coefficient on the predicted outflow rate is of lesser importance than that of the applied flow model.
482
W.J. Kostowski, J. Skorek / Energy 45 (2012) 481e488
Nomenclature
A
cross-sectional area, m2
CD
coefficient of discharge
D
diameter, m
g
gravitational acceleration, m/s2
Wojciech J. Kostowski*, Janusz Skorek
Institute of Thermal Technology, Silesian University of Technology, Konarskiego 22, PL-44-100 Gliwice, Poland
article info
The leakage quantification problem is specific for the transmission and the distribution networks respectively. For transmission networks, flow measurement data are available at each
Article history: Received 29 August 2011 Received in revised form 2 January 2012 Accepted 29 February 2012 Available online 5 April 2012
Keywords: Flow simulation Real gas Pipeline failure Leakage Discharge coefficient Gas networks
entry and exit point, so that the modelled network area may be limited to a single section of the damaged pipeline. Numerical models applied for solving the flow problem in a damaged pipe may use linearization of the governing equations based on the method of characteristics (MOC, [2,3]) or other numerical schemes (the Runge-Kutta method, [1]). The cited papers focus on transient flow simulation in pipeline sections adjacent to the failure and pay little attention on modelling the flow through the side-wall opening, which is assumed to be isentropic flow with a mass flow rate reduced by a discharge coefficient of an arbitrarily chosen, constant value (e.g. 0.8 [2]; 0.61 for subsonic flow and 1.0 elsewhere [1]).