disseration05itp6_disseration05itp6
CAS856866-72-3_Tedizolid HCl(free base)_使用方法MedBio
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBห้องสมุดไป่ตู้o
MED15401
Indolmycin
Indolmycin
21200-24-8
1mg
≥98%
Colistin Methanesulfonate (sodium salt)
Colistin Methanesulfonate (sodium salt)
8068-28-8
1g
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED15145
Tenofovir Disoproxil Fumarate
MED15316
Tedizolid HCl(free base)
Tedizolid HCl(free base)
856866-72-3
5mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED15250
Famciclovir
Famciclovir
104227-87-4
100mg
≥98%
品牌
体内研究
对于用PSSP III型感染的小鼠，使用最低总日剂量10mg / kg的tedizolid磷酸盐实现100％存活率。用tedizolid磷酸盐治疗的感染小鼠的肺显示出较少的严重炎症和水肿，如炎症和水肿的平均评分所示[1]。
3、同类产品列表：
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CAS
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MedBio
ATE Corporation AS-05 Antenna Set 30 MHz to 18 GHz
Main Features•30 MHz to 18 GHz frequency range •Excellent Antenna Factor•Tripod adapter for easy vertical-horizontal polarization change •Individual calibration•Robust, rustproof aluminium construction •LightweightAS-05 is a compact size broadband Antenna System composed of a BC-01 Biconical Dipole, LP-04 Log Periodic Dipole Array and DR-01 Double Ridged horn Antenna designed for radiated emissions and immunity testing. It can be used in conjunction with any receiver or spectrum analyzer.Its ideal companion is the EMI Receiver Unit 9060 and 9180 that can be easily mounted on the antenna mast (*).(*)The direct connection between antenna and PMM Receiver Unit eliminates additional sources of uncertainties due to coaxial cable attenuation and scattering. For further information please consult our brochure “Fully CISPR-Compliant Digital EMC/EMI receivers 10 Hz to 18 GHz”.Antenna Set 30 MHz to 18 GHzProvided by: (800)404-ATECAdvanced Test Equipment Rentals®Ordering Information:AS-05 antenna set 30 MHz to 18 GHz with individual calibration reports.AS-05/TC antenna set 30 MHz to 18 GHz with typical calibration reports.Includes: BC-01 biconical antenna; LP-04 Log-periodic antenna; DR-01Double-rideged antenna; TR-01 wooden tripod; RF cable, 6 GHz, N(m)-N(m), 5 m; Soft carrying case; Rigid carrying case (for DR-01), Operating manual; Calibration reports*.* Individual calibration reports are provided with AS-05.AS-05/TC does not include individual calibration but typical antenna factor.Optional accessories:Additional TR-01 Wooden tripod extensible 60 - 180 cm with antenna mounting adapter for fast horizontal to vertical polaritazion changing. Additional RF cable, 3 GHz, N(m)-N(m), 5 m.Sales Office:Via Leonardo da Vinci, 21/2320090 Segrate (Milano) - ITALY Phone: +39 02 2699871Fax: +39 02 26998700Headquarter:Via Benessea, 29/B17035 Cisano sul Neva (SV) - ITALY Phone: +39 0182 58641Fax: +39 0182 586400E-Mail:**************************Internet: www.narda-sts.itRelated ProductsReceiversAntennasCalibrations service• 7010/00: EMI receiver 150 kHz to 1 GHz • 7010/01: EMI receiver 9 kHz to 1 GHz • 7010/03: EMI receiver 9 kHz to 3 GHz • 9010: EMI receiver 10 Hz to 30 MHz • 9010F: EMI receiver 10 Hz to 30 MHz• 9010/03P: EMI receiver 10 Hz to 300 MHz • 9010/30P: EMI receiver 10 Hz to 3 GHz • 9010/60P: EMI receiver 10 Hz to 6 GHz • 9030: EMI Receiver 30 MHz to 3 GHz • 9060: EMI Receiver 30 MHz to 6 GHz •FR-4003: Field Receiver 9 kHz to 30 MHz• LP-02: Log Periodic Antenna 200 MHz to 3 GHz • LP-03: Log Periodic Antenna 800 MHz to 6 GHz • TR-01: Antenna Tripod• VDH-01: Van der Hoofden test-head 20 kHz to 10 MHz • Antenna Set AS-02 (BC01+LP02+TR01)• Antenna Set AS-03 (BC01+LP02+LP03+TR01) • Antenna Set AS-04 (BC01+LP04+TR01)• RA01: Rod Antenna 9 kHz to 30 MHz• RA01-HV: Rod Antenna 150 kHz to 30 MHz •RA01-MIL: Rod Antenna 9 kHz to 30 MHz• Ansi 63,5 Antenna Factor • SAE ARP 958-D• Free-Space Antenna FactorSPECIFICATIONSFrequency range GainAntenna factor Max input power Connector Dimensions (L x H x W)Weight Colour Impedance ConstructionBC-0130 to 200 MHz -15 +2 dBi typical 8 to 14 dB/m typical 100 W N-female 65 x 65 x 137 cm1,8 kg RAL 703550 Ω nominal AluminiumA S 05-F E N -60801 - S p e c i fi c a t i o n s s u b j e c t t o c h a n g e s w i t h o u t p r i o r n o t i c eAS-05Antenna set 30 MHz to 18 GHzLP-04200 MHz to 6 GHz 6 dBi typical 12 to 40 dB/m typical100 W N-female 78 x 10 x 75 cm 1,1 kg RAL 703550 Ω nominal AluminiumDR-016 to 18 GHz 9 to 16 dBi typical 36 to 41 dB/m typical 150 W N-female 55 x 44 x 177 mm 0,25 kg RAL 703550 Ω nominal AluminiumBC-01 - Antenna Factor 106141822A F (d B /m )3090150210MHz MHz MHz MHz LP-04 - Antenna Factor 155253545A F (d B /m )1356GHzGHz GHz GHz DR-01 - Antenna Factor3634384042A F (d B /m )6101418GHzGHz GHz GHz。
美国留学的常用非处方药
美国留学的常用非处方药美国留学必备的常用非处方药美国留学必备常用非处方药。
在美国留学难免有个痛疼脑热，今天店铺给大家介绍一下美国常用非处方药。
Loperamide 是最有效的治疗腹泻的非处方药。
药片和液体形式都适宜儿童服用。
但该药物不能减缓消化不良症状，建议搭配Pepto Bismol服用。
推荐品牌：Imodium, Pepto BismolPseudoephedrine 是唯一投放在市场上，用于治疗由过敏或上呼吸道感染引发的鼻塞、镇咳、祛痰药。
该药的口服溶液也适宜六岁以上的患病儿童。
它最常见的副作用是刺激肾上腺素升高，从而导致心率过快，心悸，高血压等症状。
推荐品牌：SudafedMeclizine是一款常见止吐产品，可以作为处方药或者成药。
它对于治疗晕动病(指晕船、晕车、晕飞机)非常有效。
最常见的不良反应是导致困乏嗜睡。
推荐品牌：Bonine, DramamineRanitidine 是一款非常有效的缓解胃酸过多所致的胃痛、胃灼热(烧心)非处方药。
市面上同类用于减轻胃酸或者反胃的.药物,还有Prilosec、Prevacid、Zegerid等。
其中，Prevacid适合孕期服用，缓解孕妇胃灼热。
推荐品牌：ZantacHydrocortisone cream里百分之一的药物成分是类固醇膏。
它对于治疗由感染或过敏引起的轻微皮肤不适非常有效。
患病成人或儿童均宜使用。
同类产品还推荐diphenhydramine cream。
推荐品牌：CortizoneNeosporin ointment是一款常用的抗菌药膏，主要用于治疗轻微皮肤割伤裂伤，避免再度感染。
推荐品牌：NeosporinClotrimazole主要用于治疗真菌感染。
一般通过局部涂抹来治疗皮肤上的真菌感染，比如癣菌病，尿布疹等。
用于治疗女性宫颈感染时，可以选择其栓剂或者膏药形式。
推荐品牌：LotriminIbuprofen是一种非类固醇的消炎药，也是世界卫生组织指定的必备药品之一。
SPORE SURFACE DISPLAYS OF BIOACTIVE MOLECULES
专利名称：SPORE SURFACE DISPLAYS OF BIOACTIVE MOLECULES发明人：HENRIQUES, Adriano,SCHYNS,Ghislain,WENZEL, Thibaut, José,POTOT,Sebastian申请号：EP2007007052申请日：20070809公开号：WO08/017483P1公开日：20080214专利内容由知识产权出版社提供摘要：This invention discloses novel bacterial spore systems. It has now been found surprisingly that under certain conditions bacterial spore systems can be used in the food and feed industry, preferably in animal feeding and as biohybrid material. More precisely applicant has found the following: Genetically modified or genetically engineered viable spore systems expressing bioactive polypeptides, for example bacteriocins and/or enzymatically active feed enzymes, at the spore surface, have a great potential use in animal feeding. Further, it has been found that genetically modified or 'genetically engineered inert spore systems expressing affinity ligands or immobilized enzymes at the surface have a great potential use in biocatalysis and in the construction of biocatalytic films. Especially the resistance to harsh chemicals, desiccation, strong pressure, or high temperatures allows the spores to be a potentially valuable tool for the display of bioactive molecules, like biocatalytic enzymes or bioactive feed enzymes that must survive harsh conditions to deliver their full potential. Finally, applicant has found that instead of translational fusions to spore structural genes as it is known fromthe prior art described above, passenger bioactive polypeptides, as for example enzymes, bacteriocins, affinity ligands, can also be fused to spore-specific surface enzymes, for example to spore specific enzymes as mentioned herein above.申请人：HENRIQUES, Adriano,SCHYNS, Ghislain,WENZEL, Thibaut, José,POTOT, Sebastian地址：NL,PT,CH,NL,FR国籍：NL,PT,CH,NL,FR代理机构：SCHWANDER, Kuno, Josef更多信息请下载全文后查看。
Timepidium bromide (Sesden) 35035-05-3 GlpBio
Peptides, Inhibitors, AgonistsProduct Data SheetProduct Name: Timepidium bromide (Sesden)Cat. No.:GC32666Chemical Name:CHEMICAL PROPERTIESCas No.: 35035-05-3Molecular Formula: C17H22BrNOS2Molecular Weight: 400.4Storage: PowderSolubility: Soluble in DMSOChemical Structure:BackgroundTimepidium bromide (Sesden; SA504) is an anticholinergic agent.Effects of Timepidium bromide (TB), acetylcholine (ACh) and neostigmine (Neost) on gastric and duodenal blood flow distribution are studied by the use of 131I−labeled macroaggregated human serum albumin (MAA) in rabbits. In normal ra bbits, gastric blood flow is found to be uneven in various regions of the stomach: anterior corpus (50% of total gastric blood flow) greater than posterior corpus (40%) greater than pyloric antrum (7%). Intravenous administration of Timepidium bromide (200 μg/kg) to normal rabbits produces a slight increase in total gastric blood flow, but the increase in the mucosal layer of the pyloric antrum is considerable[1].References:[1]. Naito K, et al. Effect of timepidium bromide, an anticholinergic agent, on gastric and duodenal blood flow distribution in rabbits. Jpn J Pharmacol. 1982 Feb;32(1):73-80.Research Update1. Effect of Hydrofluoric Acid Concentration and Etching Time on Bond Strength to Lithium Disilicate Glass Ceramic. Oper Dent. 2017 Nov/Dec;42(6):606-615. doi: 10.2341/16-215-L. Epub 2017 Jul 14. PMID:28708007AbstractThe aim of this study was to evaluate the influence of different concentrations of hydrofluoric acid (HF) associated with varied etchingtimes on the microshear bond strength (μSBS) of a resin cement to a lithium disilicate glass ceramic. Two hundred seventy-five ceramic blocks (IPS e.max Press [EMX], Ivoclar Vivadent), measuring 8 mm × 3 mm thickness, were randomly distributed into fiv e groups according to the HF concentrations (n=50): 1%, 2.5%, 5%, 7.5%, and 10%.2. Does acid etching morphologically and chemically affect lithium disilicate glass ceramic surfaces? J Appl Biomater Funct Mater. 2017 Jan 26;15(1):e93-e100. doi: 10.5301/jabfm.5000303. PMID:27647389AbstractBACKGROUND: This study evaluated the surface morphology, chemical composition and adhesiveness of lithium disilicate glass ceramic after acid etching with hydrofluoric acid or phosphoric acid.METHODS: Lithium disilicate glass ceramic specimens polished by 600-grit silicon carbide paper were subjected to one or a combination of these surface treatments: airborne particle abrasion with 50-μm alumina (AA), etching with 5% hydrofluoric acid (HF) or 36% phosphoric acid (Phos), and application o f silane coupling agent (Si).3. Fatigue failure load of feldspathic ceramic crowns after hydrofluoric acid etching at different concentrations. J Prosthet Dent. 2018 Feb;119(2):278-285. doi: 10.1016/j.prosdent.2017.03.021. Epub 2017 May 26. PMID:28552291AbstractSTATEMENT OF PROBLEM: Hydrofluoric acid etching modifies the cementation surface of ceramic restorations, which is the same surface where failure is initiated. Information regarding the influence of hydrofluoric acid etching on the cyclic loads to failure of ceramic crowns is lacking.PURPOSE: The purpose of this in vitro study was to evaluate the influence of different hydrofluoric acid concentrations on the fatigue failure loads of feldspathic ceramic crowns.。
萨特利斯斯泰迪姆生物技术公司Biostat RM TX产品说明书
Engineered for Life –BIOSTAT ® RM TX with Flexsafe® RM TX for Culturing Consistent Quality Cellular ProductsThe fight against cancer has taken a dra-matic step forward in recent years with the development of cellular immunotherapies such as CAR-T cells. To produce these cells to a consistent quality, manufacturers face issues including: maintaining product sterility, protecting the cell product from adverse stress or environment and maxi-mizing cell yield with efficient processing. These can be achieved with gentle expan-sion and harvesting techniques, in process controls and the use of bioanalytics to ensure lot-to-lot consistency, characterize the cellular product, as well as utilizing rapid and robust lot release testing methods.Our Competence in Cell and Gene TherapySartorius Stedim Biotech is a global solution provider to the biologics industry and is well positioned to support regenerative medicine companies with our tried and trusted technologies for applications in this sector. Utilizing our strong expertise in single-use technology and biopharmaceutical automation, Sartorius supports the development, analysis and manufacture of various types of regenerative medicines, including cellular immunotherapies.Sartorius provides a wide range of plat-forms to address the unique challenges around the production of both allogeneic and autologous cells.Solutions for Cellular ImmunotherapiesBIOSTAT ® RM TX bioreactor system and Flexsafe® RM TX bags –The Ideal Combination for Your CellsThe BIOSTAT ® RM TX and Flexsafe® RM TX bag combination provides you with an automated, wave-mixed and closed environment suitable for optimal growth of cell products in working volumes up to 5 L.The BIOSTAT ® RM TX system consists ofan automated control unit (based on our well-established BIOSTAT ® B) and a rocking platform, for gently agitating a single-use Flexsafe® RM TX bag. Enabling the ex vivo expansion of patient-specific T cells or other types of immune cells, the BIOSTAT ® RM TX is suitable for process development, as well as for the expansion of relevant cell numbers. Fed-batch, perfusion processes or a combination of culture modes are all possible with this system. You Can Rely on:– P roven industry leading Flexsafe® RM TX film that supports consistent cell growth – C losed system for minimal contamination risk– U nique gravity harvesting for maximizing cell recovery– A dvanced, automated system for walk-away monitoring and control of the cell culture including online biomass– P roven rocking motion platform for optimal cell growthBIOSTAT ® RM TX and Flexsafe® RM TX bags are for research use or further manufacturing use only – not for use in therapeutic or diagnostic procedures. They are not CE marked for in vitro diagnostic use nor are they medical devices. Drug manufacturers and clinicians are responsible for obtaining the appropriate IND | BLA | NDA approvals for clinicalapplications.The Right Solution for Your NeedsAt Sartorius, we help you develop a scalable, cost-effective process and combine this with the security of our worldwide supply chain and manufacturing capabilities. Product development in close cooperation with external industry partners guarantees the reliability of your equipment. Our expertise and experience allow us to provide you with a proven product portfolio to support early stage process development and establish scalable processes.Minimize Impact of Single-Use Material Flexsafe ® RM TX bags were introduced in June 2014 and have been used with con-tinuing success ever since by major global biopharma and cell therapy customers. The complete control of our raw materials, the extrusion process and the bag assembly, provides lot-to-lot product consistency. In collaboration with our resin and film suppliers, we have optimized the resin and minimized the additives in our Flexsafe ® film technology* ensuring excellent, reproducible batch-to-batch culture performance of even the most sensitive cells.**Protect Your Cell Product– A perfusion membrane (PES, 1.2 µm) is fixed at the bottom of the bag, forming a compartment for removal of cell free media during the perfusion process – for minimal loss or damage to the cells – S ingle-use sensors for pH, DO and viable biomass enable sophisticated process control with reduced sampling need – 100% integrity tested, gamma-irradiat-able and fully validated Sartopore ® Air sterile filters continuously protect the culture from contamination– I ndustry standard tubing option(DEHP free PVC) for seamless connection to up- & downstream processes* I ndependent labs have confirmed that Flexsafe ® bags are free of cytotoxic leachables. No bDtBPP is identified in WFI extracts of Flexsafe ® bags ** F enge et al. 2014. Consistently Superior Cell Growth: Achieved with New Polyethylene Film Formulation. Bioprocess International, Volume 12 Suppl 5.Zero Slipping Agents & Nontoxic Mechanical Antiblocking k N o risk of interference due to these agents*Optimize Cell GrowthRobust & Consistent Manufacturing Our BIOSTAT ® B control unit is ideal for walk-away automated analysis and control of high cell density perfusion cultures. Benefit from:– A dvanced control and monitoring of gas mixture and flow rate, filling volume and substrate addition; parallel activation of multiple controllers provides maximum flexibility– O n-line viable biomass analysis with culture volumes greater than 500 mL – U p to 4 internal pumps can be integrated into control loops for ease of operation without the need to constantly change the pumps' function.– E asy connection to industry standard Distributed Control (DCS) or Supervisory Control and Data Acquisition (SCADA) systems such as BioPAT ® MFCS, Siemens PCS 7 or Emerson DeltaV™.Straightforward integration into existing automation and single-use infrastructure for data and process consistency throughout– C omplete qualification of the system for GMP use to support regulatory complianceMaximize Cell YieldConventional harvesting procedures mostly use pumping which can reduce the number of live cells and affect cell viability. Since cell yield is critical for autologous cell therapies, we have designed our Flexsafe ® RM TX bags with a special port for hands-free gravity harvesting. This unique gravity harvesting concept in combination with the Flexsafe ® RM TX Harvest Device allows the safe recovery of as many cells as possible by reducing shear stress on these delicate cells and minimizes contaminationrisks from manual handling.* Patent pending.Viable biomass sensor (BioPAT ® ViaMass) integrated in the Flexsafe ® RM bag – connection to the hard-ware componentEfficient Cell ProcessingFlexsafe ® RM TX Harvest Device for hands-free gravity harvest of the cell culture with maximum recovery.BIOSTAT ® RM TXThe BIOSTAT ® RM TX system in combination with Flexsafe® RM TX bags support theculturing of consistent quality cells and is perfect for small volume autologousprocesses with multi-parallel scale out needs. Using this system, one Flexsafe® RM TX bagcan be controlled and monitored via the BIOSTAT ® B control unit. For scale-out, twoFlexsafe® RM TX bags and two separate rocking platforms can be attached to a twinBIOSTAT ® B control unit.Single | Twin ConfigurationOne controller can run up to twoBIOSTAT ® RM TX completely independentlyto save valuable lab space.12” Touch ScreenEasy-to-use and reliable operation of yourBIOSTAT ® RM TX system due to intuitivedesign of human-machine interface andadvanced touch-screen technology – evenwhile wearing laboratory gloves. IntegratedContains aeration, pumps and temperaturecontrol modules for various applicationneeds. The BioPAT® MFCS multi fermentercontrol system ensures reliable datamanagement and automation.Temperature ControlTogether with the control towerthe integrated temperature controlis optimized for small working volumesand perfusion membrane bags.Easy to UseTwo flap door magnetic lid concept forconvenient access to bag and filters.Handles allow for easy transport.Status LED – full control via DCU tower.Load CellsThe integrated precise load cells are idealfor small volume perfusion processes.The BioPAT® MFCS multi fermentercontrol system or third party SCADAsystem integration (DeltaV™) ensuresreliable data management andautomation.Protects operator & tubing frommechanical hazards of moving tray.Flexsafe ®RM TX BagsDifferent sizes of Flexsafe ® RM bags: 1 L, 2 L and 10 L total volume can be used with the BIOSTAT ® RM TX rocking platform, providing a working volume of up to 5 L. The Flexsafe ® RM TX bag has been intelligently designed with features including a special port for gravity harvesting and an internal cell retention membrane, making it ideal for perfusion culture of cellular products such as CAR-T cells.Vent FiltersSartopore ® Air filters are 100% integrity tested before gamma irradiation for improved process safety.BioPAT ®ViaMassIntegrated sensor for online biomass determination and reduced sampling need.*Perfusion MembraneIntegrated 1.2 membrane for secure cell retention during perfusion processes. No fouling and reduced shear as wave constantly flushes over the bottom fixed filter*.FilmIndustry leading proprietary Flexsafe ® film for optimal cell growth of most sensitive cells.Special harvest port for hands-freegravity harvesting. PVC tubing for seamless connectability to upstream and down-stream processes.Single use sensors for advanced process control. No cell accumulation as sensors are inserted from top into the liquid and constantly flushed.* perfusion bag design protected by patents US 9 017 997 B2 and EP 2 268 788 B1Cellular Immunotherapy ProcessesSartorius provides a wide range of single-use technologies. Our portfolio supports viral vector transduction, cell expansion and downstream processing steps including harvest, wash and concentration of cells.AnalyticsSartorius provides various analytical technologies that monitor and control your product during the entire manufacturing process.BIOSTAT STR Flexsafe ® 2D Bags– S ingle-use Flexsafe ® bags for media storage coupled with Flexsafe ® pre-designed solutions for sterile filtration, storage and transfer of media and buffers– P roven integrity to enhance process and product safety by reducing risks of contamination of valuable cell products BioPAT ® MFCS– W orld standard for supervisory process control with GAMP category 4 software package BIOSTAT STR ®– S calable, single-use bioreactor family based on stirred-tank design – W ide range of sizes (12.5 L to 2000 L working volume) and process regimes for flexible manufacturing kSep ® Centrifuge– C losed seal-less single-use fluidized bed centrifugation platform– T he opposing centrifugal and fluid flow mechanism provides low shear force which is ideal for wash & harvest of sensitive cells Biowelder ® TC– A utomated welder for sterile connection of dry or liquid filled thermoplastic tubing to support a functionally closed processProcessiQue ® Screener PLUS Platform Virus Counter ® 3100BioPAT ® Trace*Alternative:Sartorius Transfer SetsMicrosart® ATMP Mycoplasmaand Bacteria KitsCharacterization & CellBanking Services BioPAT® ViaMassService Level Agreement: All-Inclusive Coverage for Maximum Process SecurityOur Comprehensive Service Level Agreement offers the highest level of protection for your critical process equipment. Experience our worry-free contract support including our quickest reaction times and full cost coverage, in addition to the planned preventa-tive maintenance. Benefit from our technical helpdesk response within 4 hours and on-site response within 48 hours.We are working closely with customers to fully understand their needs, so we can help them address these during the early phase of their process development.We apply innovative design approaches to new product developments and test early so there is the opportunity to influence and adjust the scope.We hear what our customers tell us and are committed to serve their needs in the best possible way from start to end of the manufacturing process.Technical helpdesk response within 4 hours and on-site response within 48 hoursReaction Time Commitment:Sartorius as Your Partner for Cell and Gene Therapy ManufacturingTechnical Specifications BIOSTAT ® RM TXPower Supply (Country Specific) | Frequency | Electricity Consumption | Protection Class Rocker platform 230 V | 50 Hz | 1.3 A | IP23or120 V | 60 Hz | 2.5 A | IP23Control tower 230 V | 50 Hz | 10 A | IP21or120 V | 60 Hz | 12 A | IP21Load cells Integrated in rocker Gas Supply via BIOSTAT B Tower Inlet pressure (barg)1.5Connection hose coupling, externalHose barb for tubing with 6 mm IDGas Specification According to ISO 8573-1: dry, free of oil and dust Particle size: < 0.1 mm •Max. amount 0.1 mg/m3 (class 1) •Condensate: dew point < 3°C (class 4)•Oil < 0.01 mg/m3 (class 1) •Germs (class 0)•Operative EnvironmentAmbient temperature of between 5 – 40°CRelative humidity [%]< 80% for temperatures up to 31 °C (87.8 °F),decreasing linearly < 50% at 40 °C (104 °F)Facility and Utility RequirementsTotal Volume1 L2 L 10 L Working volume [L]*0.1 – 0.50.2 – 1 1 – 5Basic Bags for cultivations under constant conditions •••Optical Bags with SU pH & DO sensors••Perfusion Membrane Bags with SU pH & DO ••Integrated Viamass Sensor*••Flexsafe RM TX Design**•Applicable Bag Sizes and Designs* B ags with sensors might require higher minimum working volumes depending on rocking rate and angle. We recommend using 20 % of the total volume as the minimum working volume. ** i ncl. Sartopore Air Midisart vent filters, harvest port for gravity harvest, Press-In Plugs, PVC or C-Flex tubingTemperature Module Temperature controlHeating only – electrical heating plates Temperature control rangeambient temperature + 5°C to 40°C (min. set point 15°C , min. controllable temp = ambient temp. + 15°C)Temperature measurement 2°C to 50°C Temperature control accuracy (excl. measurement error)±0.2°CHeating capacity1 × 120 W (24 VDC)Over temperature protection •Gassing Module Control Tower 4-Gas mix (O 2, N 2, CO 2, air) with headspace outlet MFC– flow rates – accuracymax. 40.003 lpm – 5 lpm ± 1% full scale Advanced DO controller •Sensors & Measurement Temperature probe Pt 100•– temperature range Pt 1000 – 99°C – display resolution 0.1°C– amplifiers 1 (single) | 2 (twin)pH single use•– measurement range 6.5 – 8.5– display resolution 0.1 pH– amplifiers1 (single) |2 (twin)– recalibration function •DO single-use•– measurement range 0 – 250%– display resolution 0.1%– amplifiers1 (single) |2 (twin)– recalibration function•Process ControlDimensions W + D + H Weight MaterialBIOSTAT ® B control Tower Single | Twin 410 × 520 × 810 mm 16 × 20 × 32 in 40 | 55 kg 88 | 121 lbs Stainless steel AISI 304BIOSTAT ® RM TX Rocker complete 439 × 602 × 561 mm 17 × 24 × 22 in 35 kg 77 lbs Stainless steel, ABS Bag holder TX 430 × 602 × 86 mm 17 × 24 × 3.4 in 5.5 kg 12.1 lbs Stainless steel, ABS Lid TX430 × 602 × 495 mm 17 × 24 × 20 in 2.5 kg 5.5 lbsABS Lab-cart (optional)800 × 800 × 900 mm32 × 32 × 36 in 88 kg 194 lbsStainless steelSystem CharacteristicsSensors & MeasurementSingle-use viable biomass(BioPAT® ViaMass)Optional Integrated load cells•Media weight control range0 to 5 kg- Scale, absolute accuracy Static:± (10 + 0% of load) gDynamic:± (25 + 0% of load) g - Scale, relative accuracy Static:±3 gDynamic:±5 g*Resolution (DCU) 1 gExternal signal input max. 20 – 10 V or 4 – 20 mA Pump Module | Built-in PumpsWatson Marlow 114, fast load pump headFixed Speed for Base Addition / pHControl– Speed 5 rpmFlow rate (tubing wall thickness 1.6 mm)ID: 0.5 mm: 0 – 0.1 ml/min ID: 0.8 mm: 0.05 – 2.4 ml/min ID: 1.6 mm: 0.01 – 0.7 ml/min ID: 2.4 mm: 0.03 – 1.5 ml/min ID: 3.2 mm: 0.05 – 2.4 ml/min ID: 4.8 mm: 0.09 – 4.3 ml/minSpeed Controlled for Feed Addition– Speed 5 – 150 rpmFlow rate (tubing wall thickness 1.6 mm)ID: 0.5 mm: 0.1 – 3 ml/min ID: 0.8 mm: 0.2 – 6 ml/min ID: 1.6 mm: 0.7 – 21 ml/min ID: 2.4 mm: 1.45 – 43.5 ml/min ID: 3.2 mm: 2.35 – 70.5 ml/min ID: 4.8 mm: 4.25 – 127.5 ml/min* D ynamic weight measurement (while rocking) can be influenced by cables and tubing and interferences caused by the same.The BIOSTAT ® RM TX system is designed to communicate with industrial SCADA or DCS systems (e.g. DeltaV) through the Modbus TCP/IP protocol.Temperature Module Max. total volume (L)10 Max. working volume (L)5Rocking speed control range [rpm] 2 – 42 rpm ±1Rocking angle control range (°) 2 – 12 ± 0.3Clamping rails for bag fixation •Sensor clamps for secure fixation of glass fiber cables •Filter heater(2 variants: for std. Hepa filter or for Midisart Sartopore Air)•Safety measurement and shut-off 30 mbar Additional safety valve gasses (mbar)100 mbarWater inlet pressure reduction value 1.5 bar, integrated pressure control Different user level log in (•)Logbook function(•)Lab-cart for BIOSTAT ® B Control TowerSeparately available on requestTechnical DataCommunicationSales and Service Contacts For further contacts, visit EuropeGermanySartorius Stedim Biotech GmbH August-Spindler-Strasse 11 37079 GoettingenPhone +49.551.308.0Sartorius Stedim Systems GmbH Robert-Bosch-Strasse 5 – 7 34302 GuxhagenPhone +49.5665.407.0FranceSartorius Stedim FMT S.A.S.ZI des PaludsAvenue de Jouques – CS 91051 13781 Aubagne Cedex Phone +33.442.845600 Sartorius Stedim France SASZI des PaludsAvenue de Jouques – CS 71058 13781 Aubagne Cedex Phone +33.442.845600 AustriaSartorius Stedim Austria GmbH Modecenterstrasse 221030 ViennaPhone +43.1.7965763.18BelgiumSartorius Stedim Belgium N.V. 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Ávalos 4251B1605ECS MunroBuenos AiresPhone +54.11.4721.0505BrazilSartorius do Brasil LtdaAvenida Senador Vergueiro 2962São Bernardo do CampoCEP 09600-000 - SP- BrasilPhone +55.11.4362.8900MexicoSartorius de México, S.A. de C.V.Libramiento Norte de Tepotzotlan s/n,Colonia Barrio Tlacateco,Municipio de Tepotzotlan,Estado de México,C.P. 54605Phone +52.55.5562.1102**********************Asia|PacificAustraliaSartorius Stedim Australia Pty. Ltd.Unit 5, 7-11 Rodeo DriveDandenong South Vic 3175Phone +61.3.8762.1800ChinaSartorius Stedim (Shanghai)Trading Co., Ltd.3rd Floor, North Wing, Tower 1No. 4560 Jinke RoadZhangjiang Hi-Tech ParkPudong DistrictShanghai 201210, P.R. ChinaPhone +86.21.6878.2300Sartorius Stedim (Shanghai)Trading Co., Ltd.Beijing Branch OfficeNo. 33 Yu’an RoadAirport Industrial Park Zone BShunyi District, Beijing 101300Phone +86.10.8042.6501Sartorius Stedim (Shanghai)Trading Co., Ltd.Guangzhou Branch OfficeRoom 1105Xing Guang Ying Jing BuildingNo. 119, Shui Yin RoadYue Xiu District, Guangzhou 510075Phone +86.20.3836.4193IndiaSartorius Stedim India Pvt. Ltd.#69/2-69/3, NH 48, JakkasandraNelamangala Tq562 123 Bangalore, IndiaPhone +91.80.4350.5250JapanSartorius Stedim Japan K.K.4th Fl., Daiwa Shinagawa North Bldg.8-11, Kita-Shinagawa 1-chomeShinagawa-ku, Tokyo, 140-0001 JapanPhone +81.3.4331.4300MalaysiaSartorius Stedim Malaysia Sdn. Bhd.Lot L3-E-3B, Enterprise 4Technology Park MalaysiaBukit Jalil57000 Kuala Lumpur, MalaysiaPhone +60.3.8996.0622SingaporeSartorius Stedim Singapore Pte. Ltd.10 Science Park RdThe Alpha #02-13/14Singapore Science Park IISingapore 117684Phone +65.6872.3966South KoreaSartorius Korea Biotech Co., Ltd.8th Floor, Solid Space B/D,PanGyoYeok-Ro 220, BunDang-GuSeongNam-Si, GyeongGi-Do, 463-400Phone +82.31.622.5700 S p e c i f icationssubjecttochangewithoutnotice.CopyrightSartoriusStedimBiotechGmbH.PrintedintheEUonpaperbleachedwithoutchlorine.Version1/219/1。
EPZ-5676_1380288-87-8_DataSheet_MedChemExpress
P d t D t Sh t Product Name:EPZ-5676CAS No.:1380288-87-8Cat. No.:HY-15593Product Data SheetMWt:562.71Formula:C30H42N8O3Purity :>98%Solubility:DMSO 100 mg/ml; Water <1 mg/mlMechanisms:Biological Activity:EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase with Ki of 80pM;demonstrating >37000fold selectivity against all other PMTs tested inhibitsPathways:Cell Cycle/DNA Damage; Target:HMTase with Ki of 80 pM; demonstrating >37,000-fold selectivity against all other PMTs tested, inhibitsH3K79 methylation in tumor.IC50 Value: 80 pM (Ki value) [1]Target: in vitro: The compound has a Ki value of 80 pM, and demonstrates 37,000-fold selectivity over all other methyltransferases tested. In cellular studies, EPZ-5676inhibited H3K79 methylation and MLL-fusion target gene expression and demonstrated potent cell killing that was selective for acuteleukemia lines bearing MLL translocations [1].in vivo: Continuous intravenous (IV) infusion of EPZ-5676 in a rat xenograft model of MLL-References:[1]. Daigle SR, Olhava EJ, Therkelsen CA, Potent inhibition of DOT1L as treatment for MLL-fusionleukemia. Blood. 2013 Jun 25. [Epub ahead of print]rearranged leukemia caused complete tumor regressions that were sustained well beyond thecompound infusion period with no significant weight loss or signs of toxicity [1].Clinical tri...Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AE m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。
MONOCLONAL ANTIBODY AND IMMUNOACTIVITY ASSAY FOR H
专利名称：MONOCLONAL ANTIBODY ANDIMMUNOACTIVITY ASSAY FOR HUMANALKALI PHOSPHATASE ISOZYME USINGSAME发明人：KURONO MASATSUNE,MITANITAKAHIKO,HAYASHI YUJI,SUGIURAMAMORU,HIRANO KAZUYUKI,SAWAI KIICHI 申请号：JP18354088申请日：19880725公开号：JPH0235098A公开日：19900205专利内容由知识产权出版社提供摘要：PURPOSE:To enable diseases corresponding to each isozyme to be diagnosed by discriminately using monoclonal antibodies specific to each of the three kinds of isozymes for human alkali phosphatase. CONSTITUTION:Of the three kinds of isozymes for human alkali phosphatase(AP), a monoclonal antibody(MCB) specific to human small intestine-type AP is used to detect the variation in activity values for the small intestine-type AP, thus obtaining the information on both acute and chronic hepatitis and cirrhosis. Or using a second MCB specific to human placenta-type AP, variation in activity values for the placenta-type AP, thus obtaining the information on orchioncus, carcinoma of uterine cervix and ovarian carcinoma. Or a third MCB specific to human liver/bone/kidney-type AP is used to detect variation in the corresponding AP activity values, thus obtaining the information on hepatobiliary diseases and osteopathy. The above respective MCBs can be obtained using established techniques.申请人：SANWA KAGAKU KENKYUSHO CO LTD 更多信息请下载全文后查看。
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New Technology for Controlling Micro-pores in Cordierite Diesel Particulate Filters
Mikio ISHIHARA Yuichi HIRATSUKA Mitsunori OHTA Juji SUZUKI
Nobuyuki TAKAGI
Fig. 1 Diesel particulate filter
The DPF (Diesel Particulate Filter), which simultaneously removes PM (Particulate Matter) and NOx from the exhaust of diesel vehicles, is required in order to achieve hig h PM filtering efficiency and meet diesel emission regulations as well as to realize low back pressure and reduce power loss. However, these requirements come at the expense of a trade-off between filtering efficiency and low back pressure. Therefore, it is necessary to optimize the pore distribution in the walls of the DPF in order to satisfy both characteristics. This paper will explain how optimized control of pore distribution enables both high PM filtering efficiency and low back pressure.Key words :Particulate trap, Catalyst, Ceramic, Controlling micro-pore, Diesel Particulate Filter
Fig. 2 Behavior of the mean pore diameter vs. PM
filtering efficiency
Fig. 4 Back pressure equations of DPF
∆P B
∆P B
∆P cell
∆P wall
D: DPF diameter Fig. 5 Behavior of mean pore diameter vs. back
pressure
Fig. 3 Behavior of porosity vs.isostatic strength
Fig. 7 Characteristics of material B
Fig. 8 Characteristics of material C
Fig. 6 Characteristics of material A
Fig. 9 Characeristics of material D
P o r o s i t y (%)
Diameter ratio (-)
Amount of pore former (%)
)
Fig. 11 PM filtering efficency
Fig. 10 Characeristics of material E
P o r o s i t y (%)
Diameter ratio (-)
Amount of pore former (%)
%)
Fig. 12 Half width of DPF materials
Fig. 15 PM Filtering efficiency after improvement
Fig. 16 Back pressure after improvement Fig. 13 Behavior of the half width vs. huge and micro
pore rate
Fig. 14 Pore size distribution after improvement
Fig. 17 Isostatic strength after improvement
1.21.00.80.60.40.20.0
I s o s t a t i c s t r e n g t h r a t i o (-)
DPF
Improved DPF
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