Ispinesib_COA_14035_MedChemExpress
Med Chem IDO inhibitors review (in Chinese)
第 2期
孔令雷等 : IDO 抑制剂的研究进展
此 , D-1 M T 被美国 国立癌 症研究 所列 入 RA ID ( rapid access to intervent io n deve lop m ent ) 计
划
[ 20]
, 并于 2007 年秋进入 I 2008- 11- 27 基金项目 : 国家自然科学基金项目 ( 30873153); 上海市 / 科技创新行动 0 2008 年度生物医药重点项目 ( 08431902700) 作者简介 : 孔令雷 ( 1984- ), 男 ( 汉族 ), 山东曲阜人 , 硕士研究 生 ; 杨青 ( 1968 - ), 女 ( 汉族 ), 辽 宁丹东 人 , 副 教授 , 硕士生导师 , 主 要从 事药 物先 导 化合 物的 发 现、 药物 分 子设 计、 药 物动 态 学等 领 域 的研 究 , T e : l ( 021) 54237692, E-ma i: l yangqing68@ fudan. edu . cn 。
。
2004年 , L i等
[ 21]
运用 SchÊ llkopf手性辅剂首
trp , K i = 111 4 Lm o # lL
- 1
148
[ 14] [ 13]
物系统中, 化合 物 2 的 D 型光 学异 构体更 为有 效。 H ou 等 发现在混合淋巴 细胞应答试验中 表达 I D O 的 DC 抑制 了 T 细胞的 活化, 而 D-1 M T 比 L -1 -M T 能更有效地减轻这种抑制 ; M uller 等 发现 D -1 -M T 能与化学或放射疗法结合, 其 治疗鼠乳腺癌和黑素瘤比 L-1M T 的效果 更好, 这表明 D-1M T 在体内具有更高抗肿瘤活性。因
气道上皮细胞在过敏性哮喘固有免疫应答中的作用研究进展
气道上皮细胞在过敏性哮喘固有免疫应答中的作用研究进展李为强郑晔姜晓峰（哈尔滨医科大学附属第四医院检验科，哈尔滨 150001）中图分类号R562.2 文献标志码 A 文章编号1000-484X（2023）09-2003-05［摘要］过敏性哮喘是一种发病率逐年升高的慢性疾病，典型表现是气道炎症和气道高反应性。
气道上皮细胞（AEC）作为抵御多种过敏原的第一道屏障，能够率先启动固有免疫应答参与过敏性哮喘，AEC通过分泌抗微生物物质、表达模式识别受体、分泌固有免疫因子、参与固有免疫记忆的方式调节适应性免疫应答，影响过敏性哮喘的进程。
因此AEC被认为是过敏性哮喘中肺部炎症和免疫应答的调节枢纽。
另外，针对AEC固有免疫功能的靶向治疗药物也得到了快速发展，为临床治疗过敏性哮喘提供了更多选择。
［关键词］气道上皮细胞；过敏性哮喘；固有免疫应答；固有免疫记忆Research progress on role of airway epithelial cells in innate immune response of allergic asthmaLI Weiqiang，ZHENG Ye，JIANG Xiaofeng. Department of Clinical Laboratory，the Fourth Hospital of Harbin Medical University， Harbin 150001， China［Abstract］Allergic asthma is a chronic disease with an increasing incidence year by year. The typical manifestations are air‐way inflammation and airway hyperresponsiveness. Airway epithelial cell （AEC）， as the first barrier against a variety of allergens， can be the first to initiate the innate immune response to participate in allergic asthma. AEC regulates the adaptive immune response by se‐creting antimicrobial substances， expressing pattern recognition receptors， secreting innate immune factors， participating in innate im‐mune memory and affects the process of allergic asthma. Therefore， AEC is considered to be the regulatory hub of lung inflammation and immune response in allergic asthma. In addition， targeted therapy drugs for the innate immune function of AEC have also been developed rapidly， providing more options for clinical treatment of allergic asthma.［Key words］Airway epithelial cell；Allergic asthma；Innate immune response；Innate immune memory过敏性哮喘是一种常见的慢性呼吸道疾病，流行病学调查发现，全球有3亿多人患有过敏性哮喘［1］。
SCItop区期刊表
刊名简称刊名全称ATMOS CHEM PHYS ATMOSPHERIC CHEMISTRY AND PHYSICSB AM METEOROL SOC BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY CLIM DYNAM CLIMATE DYNAMICSCONTRIB MINERAL PETR CONTRIBUTIONS TO MINERALOGY AND PETROLOGY EARTH PLANET SC LETT EARTH AND PLANETARY SCIENCE LETTERSEARTH-SCI REV EARTH-SCIENCE REVIEWSGEOCHIM COSMOCHIM AC GEOCHIMICA ET COSMOCHIMICA ACTAGEOLOGY GEOLOGYGEOTEXT GEOMEMBRANES GEOTEXTILES AND GEOMEMBRANESJ CLIMATE JOURNAL OF CLIMATEJ PETROL JOURNAL OF PETROLOGYLIMNOL OCEANOGR LIMNOLOGY AND OCEANOGRAPHYNAT GEOSCI Nature GeosciencePALEOCEANOGRAPHY PALEOCEANOGRAPHYPRECAMBRIAN RES PRECAMBRIAN RESEARCHQUATERNARY SCI REV QUATERNARY SCIENCE REVIEWSREV GEOPHYS REVIEWS OF GEOPHYSICSGEOPHYS RES LETT GEOPHYSICAL RESEARCH LETTERSJ ATMOS SCI JOURNAL OF THE ATMOSPHERIC SCIENCESJ GEOPHYS RES JOURNAL OF GEOPHYSICAL RESEARCHJ HYDROL JOURNAL OF HYDROLOGYMON WEATHER REV MONTHLY WEATHER REVIEWANNU REV ASTRON ASTR ANNUAL REVIEW OF ASTRONOMY AND ASTROPHYSICS ASTRON ASTROPHYS REV ASTRONOMY AND ASTROPHYSICS REVIEWASTROPHYS J SUPPL S ASTROPHYSICAL JOURNAL SUPPLEMENT SERIES ASTROPHYS J ASTROPHYSICAL JOURNALACM COMPUT SURV ACM COMPUTING SURVEYSACM T GRAPHIC ACM TRANSACTIONS ON GRAPHICSACS NANO ACS NanoACTA BIOMATER Acta BiomaterialiaACTA MATER ACTA MATERIALIAADV APPL MECH ADVANCES IN APPLIED MECHANICSADV BIOCHEM ENG BIOT ADVANCES IN BIOCHEMICAL ENGINEERING / BIOTECHNOL ADV FUNCT MATER ADVANCED FUNCTIONAL MATERIALSADV MATER ADVANCED MATERIALSANNU REV BIOMED ENG ANNUAL REVIEW OF BIOMEDICAL ENGINEERINGANNU REV MATER RES ANNUAL REVIEW OF MATERIALS RESEARCHAPPL SPECTROSC REV APPLIED SPECTROSCOPY REVIEWSARTIF INTELL ARTIFICIAL INTELLIGENCEBIOMATERIALS BIOMATERIALSBIORESOURCE TECHNOL BIORESOURCE TECHNOLOGYBIOSENS BIOELECTRON BIOSENSORS & BIOELECTRONICSBIOTECHNOL ADV BIOTECHNOLOGY ADVANCESBIOTECHNOL BIOENG BIOTECHNOLOGY AND BIOENGINEERINGBIOTECHNOL BIOFUELS Biotechnology for BiofuelsCARBON CARBONCHEM MATER CHEMISTRY OF MATERIALSCOMPUT INTELL COMPUTATIONAL INTELLIGENCECRIT REV BIOTECHNOL CRITICAL REVIEWS IN BIOTECHNOLOGYCRIT REV FOOD SCI CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION CURR OPIN BIOTECH CURRENT OPINION IN BIOTECHNOLOGY ELECTROCHEM COMMUN ELECTROCHEMISTRY COMMUNICATIONSHUM-COMPUT INTERACT HUMAN-COMPUTER INTERACTIONIEEE J SEL AREA COMM IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS IEEE SIGNAL PROC MAG IEEE SIGNAL PROCESSING MAGAZINEIEEE T EVOLUT COMPUT IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION IEEE T IND ELECTRON IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS IEEE T NEURAL NETWOR IEEE TRANSACTIONS ON NEURAL NETWORKSIEEE T PATTERN ANAL IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHIN IEEE T SOFTWARE ENG IEEE TRANSACTIONS ON SOFTWARE ENGINEERINGINT J COMPUT VISION INTERNATIONAL JOURNAL OF COMPUTER VISIONINT J HYDROGEN ENERG INTERNATIONAL JOURNAL OF HYDROGEN ENERGYINT J NONLIN SCI NUM INTERNATIONAL JOURNAL OF NONLINEAR SCIENCES AND INT J PLASTICITY INTERNATIONAL JOURNAL OF PLASTICITYINT MATER REV INTERNATIONAL MATERIALS REVIEWSJ CATAL JOURNAL OF CATALYSISJ HAZARD MATER JOURNAL OF HAZARDOUS MATERIALSJ MATER CHEM JOURNAL OF MATERIALS CHEMISTRYJ MECH BEHAV BIOMED Journal of the Mechanical Behavior of Biomedical J NEURAL ENG Journal of Neural EngineeringJ POWER SOURCES JOURNAL OF POWER SOURCESJ WEB SEMANT Journal of Web SemanticsLAB CHIP LAB ON A CHIPMACROMOL RAPID COMM MACROMOLECULAR RAPID COMMUNICATIONS MACROMOLECULES MACROMOLECULESMAT SCI ENG R MATERIALS SCIENCE & ENGINEERING R-REPORTS MATER TODAY Materials TodayMED IMAGE ANAL MEDICAL IMAGE ANALYSISMETAB ENG METABOLIC ENGINEERINGMIS QUART MIS QUARTERLYMOL NUTR FOOD RES MOLECULAR NUTRITION & FOOD RESEARCHMRS BULL MRS BULLETINNANO LETT NANO LETTERSNANO TODAY Nano TodayNANOMED-NANOTECHNOL Nanomedicine-Nanotechnology Biology and Medicine NANOTECHNOLOGY NANOTECHNOLOGYNAT BIOTECHNOL NATURE BIOTECHNOLOGYNAT MATER NATURE MATERIALSNAT NANOTECHNOL Nature NanotechnologyORG ELECTRON ORGANIC ELECTRONICSP IEEE PROCEEDINGS OF THE IEEEPLASMONICS PlasmonicsPOLYM REV Polymer ReviewsPROG CRYST GROWTH CH PROGRESS IN CRYSTAL GROWTH AND CHARACTERIZATION PROG ENERG COMBUST PROGRESS IN ENERGY AND COMBUSTION SCIENCEPROG MATER SCI PROGRESS IN MATERIALS SCIENCEPROG PHOTOVOLTAICS PROGRESS IN PHOTOVOLTAICSPROG QUANT ELECTRON PROGRESS IN QUANTUM ELECTRONICSPROG SURF SCI PROGRESS IN SURFACE SCIENCERENEW SUST ENERG REV RENEWABLE & SUSTAINABLE ENERGY REVIEWSSMALL SMALLSOFT MATTER Soft MatterTRENDS BIOTECHNOL TRENDS IN BIOTECHNOLOGYTRENDS FOOD SCI TECH TRENDS IN FOOD SCIENCE & TECHNOLOGYVLDB J VLDB JOURNALAICHE J AICHE JOURNALAPPL MICROBIOL BIOT APPLIED MICROBIOLOGY AND BIOTECHNOLOGYCHEM ENG SCI CHEMICAL ENGINEERING SCIENCEELECTROCHIM ACTA ELECTROCHIMICA ACTAFOOD CHEM FOOD CHEMISTRYIEEE T ANTENN PROPAG IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION IEEE T AUTOMAT CONTR IEEE TRANSACTIONS ON AUTOMATIC CONTROLIEEE T INFORM THEORY IEEE TRANSACTIONS ON INFORMATION THEORYIEEE T MICROW THEORY IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNI IEEE T SIGNAL PROCES IEEE TRANSACTIONS ON SIGNAL PROCESSINGIND ENG CHEM RES INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCHINT J HEAT MASS TRAN INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER J AM CERAM SOC JOURNAL OF THE AMERICAN CERAMIC SOCIETYJ ELECTROCHEM SOC JOURNAL OF THE ELECTROCHEMICAL SOCIETYJ MEMBRANE SCI JOURNAL OF MEMBRANE SCIENCEMATER LETT MATERIALS LETTERSSCRIPTA MATER SCRIPTA MATERIALIASENSOR ACTUAT B-CHEM SENSORS AND ACTUATORS B-CHEMICALSURF COAT TECH SURFACE & COATINGS TECHNOLOGYSYNTHETIC MET SYNTHETIC METALSTHIN SOLID FILMS THIN SOLID FILMSJ OPER MANAG JOURNAL OF OPERATIONS MANAGEMENTMANAGE SCI MANAGEMENT SCIENCEOMEGA-INT J MANAGE S OMEGA-INTERNATIONAL JOURNAL OF MANAGEMENT SCIENC PROD OPER MANAG PRODUCTION AND OPERATIONS MANAGEMENTEUR J OPER RES EUROPEAN JOURNAL OF OPERATIONAL RESEARCH ACCOUNTS CHEM RES ACCOUNTS OF CHEMICAL RESEARCHACTA CRYSTALLOGR A ACTA CRYSTALLOGRAPHICA SECTION AALDRICHIM ACTA ALDRICHIMICA ACTAANGEW CHEM INT EDIT ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONANNU REV PHYS CHEM ANNUAL REVIEW OF PHYSICAL CHEMISTRYCATAL REV CATALYSIS REVIEWS-SCIENCE AND ENGINEERINGCHEM REV CHEMICAL REVIEWSCHEM SOC REV CHEMICAL SOCIETY REVIEWSCOORDIN CHEM REV COORDINATION CHEMISTRY REVIEWSENERG ENVIRON SCI Energy & Environmental ScienceINT REV PHYS CHEM INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRYJ AM CHEM SOC JOURNAL OF THE AMERICAN CHEMICAL SOCIETYJ PHOTOCH PHOTOBIO C JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHO NAT PROD REP NATURAL PRODUCT REPORTSPROG POLYM SCI PROGRESS IN POLYMER SCIENCESURF SCI REP SURFACE SCIENCE REPORTSTRAC-TREND ANAL CHEM TRAC-TRENDS IN ANALYTICAL CHEMISTRYANAL CHEM ANALYTICAL CHEMISTRYJ ORG CHEM JOURNAL OF ORGANIC CHEMISTRYJ PHYS CHEM B JOURNAL OF PHYSICAL CHEMISTRY BLANGMUIR LANGMUIRAPPL CATAL B-ENVIRON APPLIED CATALYSIS B-ENVIRONMENTALB AM MUS NAT HIST BULLETIN OF THE AMERICAN MUSEUM OF NATURAL HISTO CRIT REV ENV SCI TEC CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TE ECOL LETT ECOLOGY LETTERSECOL MONOGR ECOLOGICAL MONOGRAPHSECOLOGY ECOLOGYENVIRON HEALTH PERSP ENVIRONMENTAL HEALTH PERSPECTIVESENVIRON MICROBIOL ENVIRONMENTAL MICROBIOLOGYEVOLUTION EVOLUTIONFRONT ECOL ENVIRON FRONTIERS IN ECOLOGY AND THE ENVIRONMENT GLOBAL CHANGE BIOL GLOBAL CHANGE BIOLOGYGLOBAL ECOL BIOGEOGR GLOBAL ECOLOGY AND BIOGEOGRAPHYISME J ISME JournalATMOS ENVIRON ATMOSPHERIC ENVIRONMENTCHEMOSPHERE CHEMOSPHEREENVIRON SCI TECHNOL ENVIRONMENTAL SCIENCE & TECHNOLOGYWATER RES WATER RESEARCHADV AGRON ADVANCES IN AGRONOMYAGR FOREST METEOROL AGRICULTURAL AND FOREST METEOROLOGYATLA-ALTERN LAB ANIM ATLA-ALTERNATIVES TO LABORATORY ANIMALSEUR J SOIL SCI EUROPEAN JOURNAL OF SOIL SCIENCEFISH FISH FISH AND FISHERIESFISH OCEANOGR FISHERIES OCEANOGRAPHYFISH SHELLFISH IMMUN FISH & SHELLFISH IMMUNOLOGYFOOD BIOPROCESS TECH Food and Bioprocess TechnologyGEODERMA GEODERMAILAR J ILAR JOURNALJ AGR FOOD CHEM JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRYJ ANIM SCI JOURNAL OF ANIMAL SCIENCEJ DAIRY SCI JOURNAL OF DAIRY SCIENCEMOL BREEDING MOLECULAR BREEDINGREV FISH BIOL FISHER REVIEWS IN FISH BIOLOGY AND FISHERIESSOIL BIOL BIOCHEM SOIL BIOLOGY & BIOCHEMISTRYSOIL SCI SOC AM J SOIL SCIENCE SOCIETY OF AMERICA JOURNALTREE PHYSIOL TREE PHYSIOLOGYVET MICROBIOL VETERINARY MICROBIOLOGYVET RES VETERINARY RESEARCHAQUACULTURE AQUACULTURECAN J FISH AQUAT SCI CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENC FOREST ECOL MANAG FOREST ECOLOGY AND MANAGEMENTJAVMA-J AM VET MED A JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL PLANT SOIL PLANT AND SOILAM J BIOETHICS AMERICAN JOURNAL OF BIOETHICSECONOMETRICA ECONOMETRICAJ ECONOMETRICS JOURNAL OF ECONOMETRICSAM J HUM GENET AMERICAN JOURNAL OF HUMAN GENETICSANNU REV BIOCHEM ANNUAL REVIEW OF BIOCHEMISTRYANNU REV BIOPH BIOM ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STR ANNU REV BIOPHYS Annual Review of BiophysicsANNU REV CELL DEV BI ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY ANNU REV ECOL EVOL S ANNUAL REVIEW OF ECOLOGY EVOLUTION AND SYSTEMATI ANNU REV ENTOMOL ANNUAL REVIEW OF ENTOMOLOGYANNU REV GENET ANNUAL REVIEW OF GENETICSANNU REV GENOM HUM G ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS ANNU REV MICROBIOL ANNUAL REVIEW OF MICROBIOLOGYANNU REV PHYTOPATHOL ANNUAL REVIEW OF PHYTOPATHOLOGYANNU REV PLANT BIOL ANNUAL REVIEW OF PLANT BIOLOGYCELL CELLCELL HOST MICROBE Cell Host & MicrobeCELL METAB Cell MetabolismCELL STEM CELL Cell Stem CellCRIT REV BIOCHEM MOL CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR B CURR BIOL CURRENT BIOLOGYCURR OPIN CELL BIOL CURRENT OPINION IN CELL BIOLOGYCURR OPIN GENET DEV CURRENT OPINION IN GENETICS & DEVELOPMENTCURR OPIN PLANT BIOL CURRENT OPINION IN PLANT BIOLOGYCURR OPIN STRUC BIOL CURRENT OPINION IN STRUCTURAL BIOLOGYDEV CELL DEVELOPMENTAL CELLGENE DEV GENES & DEVELOPMENTGENOME RES GENOME RESEARCHJ CELL BIOL JOURNAL OF CELL BIOLOGYMICROBIOL MOL BIOL R MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWSMOL CELL MOLECULAR CELLMOL SYST BIOL Molecular Systems BiologyNAT CELL BIOL NATURE CELL BIOLOGYNAT CHEM BIOL Nature Chemical BiologyNAT GENET NATURE GENETICSNAT METHODS NATURE METHODSNAT REV GENET NATURE REVIEWS GENETICSNAT REV MICROBIOL NATURE REVIEWS MICROBIOLOGYNAT REV MOL CELL BIO NATURE REVIEWS MOLECULAR CELL BIOLOGYNAT STRUCT MOL BIOL NATURE STRUCTURAL & MOLECULAR BIOLOGYPLANT CELL PLANT CELLPLOS BIOL PLOS BIOLOGYPLOS GENET PLoS GeneticsPLOS PATHOG PLoS PathogensPROG LIPID RES PROGRESS IN LIPID RESEARCHQ REV BIOPHYS QUARTERLY REVIEWS OF BIOPHYSICSTRENDS BIOCHEM SCI TRENDS IN BIOCHEMICAL SCIENCESTRENDS CELL BIOL TRENDS IN CELL BIOLOGYTRENDS ECOL EVOL TRENDS IN ECOLOGY & EVOLUTIONTRENDS GENET TRENDS IN GENETICSTRENDS PLANT SCI TRENDS IN PLANT SCIENCEAPPL ENVIRON MICROB APPLIED AND ENVIRONMENTAL MICROBIOLOGY BIOCHEM J BIOCHEMICAL JOURNALBIOPHYS J BIOPHYSICAL JOURNALDEVELOPMENT DEVELOPMENTEMBO J EMBO JOURNALJ BACTERIOL JOURNAL OF BACTERIOLOGYJ BIOL CHEM JOURNAL OF BIOLOGICAL CHEMISTRYJ MOL BIOL JOURNAL OF MOLECULAR BIOLOGYMOL CELL BIOL MOLECULAR AND CELLULAR BIOLOGYNUCLEIC ACIDS RES NUCLEIC ACIDS RESEARCHPLANT PHYSIOL PLANT PHYSIOLOGYACTA MATH-DJURSHOLM ACTA MATHEMATICAANN MATH ANNALS OF MATHEMATICSANN STAT ANNALS OF STATISTICSB AM MATH SOC BULLETIN OF THE AMERICAN MATHEMATICAL SOCIETY COMMUN PUR APPL MATH COMMUNICATIONS ON PURE AND APPLIED MATHEMATICS FOUND COMPUT MATH FOUNDATIONS OF COMPUTATIONAL MATHEMATICS INVENT MATH INVENTIONES MATHEMATICAEINVERSE PROBL INVERSE PROBLEMSJ AM MATH SOC JOURNAL OF THE AMERICAN MATHEMATICAL SOCIETYJ AM STAT ASSOC JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION J R STAT SOC B JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES MATH MOD METH APPL S MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCE MATH PROGRAM MATHEMATICAL PROGRAMMINGMEM AM MATH SOC MEMOIRS OF THE AMERICAN MATHEMATICAL SOCIETY MULTISCALE MODEL SIM MULTISCALE MODELING & SIMULATIONMULTIVAR BEHAV RES MULTIVARIATE BEHAVIORAL RESEARCHNONLINEAR ANAL-REAL NONLINEAR ANALYSIS-REAL WORLD APPLICATIONSRISK ANAL RISK ANALYSISSIAM REV SIAM REVIEWSTAT SCI STATISTICAL SCIENCESTRUCT EQU MODELING STRUCTURAL EQUATION MODELING-A MULTIDISCIPLINARY FUZZY SET SYST FUZZY SETS AND SYSTEMSJ COMPUT APPL MATH JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS J DIFFER EQUATIONS JOURNAL OF DIFFERENTIAL EQUATIONSJ MATH ANAL APPL JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONNONLINEAR ANAL-THEOR NONLINEAR ANALYSIS-THEORY METHODS & APPLICATIONS SIAM J NUMER ANAL SIAM JOURNAL ON NUMERICAL ANALYSISSIAM J SCI COMPUT SIAM JOURNAL ON SCIENTIFIC COMPUTINGACTA CRYSTALLOGR A ACTA CRYSTALLOGRAPHICA SECTION AADV PHYS ADVANCES IN PHYSICSANNU REV FLUID MECH ANNUAL REVIEW OF FLUID MECHANICSANNU REV NUCL PART S ANNUAL REVIEW OF NUCLEAR AND PARTICLE SCIENCE CRIT REV SOLID STATE CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SC J HIGH ENERGY PHYS JOURNAL OF HIGH ENERGY PHYSICSLASER PHOTONICS REV Laser & Photonics ReviewsLIVING REV RELATIV Living Reviews in RelativityMASS SPECTROM REV MASS SPECTROMETRY REVIEWSNAT PHOTONICS Nature PhotonicsNAT PHYS Nature PhysicsPHYS REP PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTER PHYS REV LETT PHYSICAL REVIEW LETTERSPROG NUCL MAG RES SP PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSC REP PROG PHYS REPORTS ON PROGRESS IN PHYSICSREV MOD PHYS REVIEWS OF MODERN PHYSICSAPPL PHYS LETT APPLIED PHYSICS LETTERSJ CHEM PHYS JOURNAL OF CHEMICAL PHYSICSPHYS REV B PHYSICAL REVIEW BPHYS REV D PHYSICAL REVIEW DADV DRUG DELIVER REV ADVANCED DRUG DELIVERY REVIEWSADV IMMUNOL ADVANCES IN IMMUNOLOGYAM J CLIN NUTR AMERICAN JOURNAL OF CLINICAL NUTRITIONAM J GASTROENTEROL AMERICAN JOURNAL OF GASTROENTEROLOGYAM J PSYCHIAT AMERICAN JOURNAL OF PSYCHIATRYAM J RESP CRIT CARE AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CAR AM J TRANSPLANT AMERICAN JOURNAL OF TRANSPLANTATIONANN INTERN MED ANNALS OF INTERNAL MEDICINEANN NEUROL ANNALS OF NEUROLOGYANN RHEUM DIS ANNALS OF THE RHEUMATIC DISEASESANN SURG ANNALS OF SURGERYANNU REV IMMUNOL ANNUAL REVIEW OF IMMUNOLOGYANNU REV MED ANNUAL REVIEW OF MEDICINEANNU REV NEUROSCI ANNUAL REVIEW OF NEUROSCIENCEANNU REV NUTR ANNUAL REVIEW OF NUTRITIONANNU REV PATHOL-MECH Annual Review of Pathology-Mechanisms of Disease ANNU REV PHARMACOL ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY ANNU REV PHYSIOL ANNUAL REVIEW OF PHYSIOLOGYANNU REV PSYCHOL ANNUAL REVIEW OF PSYCHOLOGYANNU REV PUBL HEALTH ANNUAL REVIEW OF PUBLIC HEALTHARCH GEN PSYCHIAT ARCHIVES OF GENERAL PSYCHIATRYARCH INTERN MED ARCHIVES OF INTERNAL MEDICINEARTERIOSCL THROM VAS ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY ARTHRITIS RHEUM-US ARTHRITIS AND RHEUMATISMBBA-REV CANCER BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER BEHAV BRAIN SCI BEHAVIORAL AND BRAIN SCIENCESBIOL PSYCHIAT BIOLOGICAL PSYCHIATRYBLOOD BLOODBLOOD REV BLOOD REVIEWSBRAIN BRAINBRAIN RES REV BRAIN RESEARCH REVIEWSBRIT MED J BRITISH MEDICAL JOURNALCA-CANCER J CLIN CA-A CANCER JOURNAL FOR CLINICIANSCAN MED ASSOC J CANADIAN MEDICAL ASSOCIATION JOURNALCANCER CELL CANCER CELLCANCER METAST REV CANCER AND METASTASIS REVIEWSCANCER RES CANCER RESEARCHCEREB CORTEX CEREBRAL CORTEXCIRC RES CIRCULATION RESEARCHCIRCULATION CIRCULATIONCLIN CANCER RES CLINICAL CANCER RESEARCHCLIN INFECT DIS CLINICAL INFECTIOUS DISEASESCLIN MICROBIOL REV CLINICAL MICROBIOLOGY REVIEWSCLIN PHARMACOL THER CLINICAL PHARMACOLOGY & THERAPEUTICSCRIT CARE MED CRITICAL CARE MEDICINECURR OPIN IMMUNOL CURRENT OPINION IN IMMUNOLOGYCURR OPIN LIPIDOL CURRENT OPINION IN LIPIDOLOGYCURR OPIN NEUROBIOL CURRENT OPINION IN NEUROBIOLOGYCURR OPIN PHARMACOL CURRENT OPINION IN PHARMACOLOGYDIABETES DIABETESDIABETES CARE DIABETES CAREDIABETOLOGIA DIABETOLOGIADRUG DISCOV TODAY DRUG DISCOVERY TODAYDRUG RESIST UPDATE DRUG RESISTANCE UPDATESEMERG INFECT DIS EMERGING INFECTIOUS DISEASESENDOCR REV ENDOCRINE REVIEWSEPIDEMIOL REV EPIDEMIOLOGIC REVIEWSEUR HEART J EUROPEAN HEART JOURNALEUR UROL EUROPEAN UROLOGYFRONT NEUROENDOCRIN FRONTIERS IN NEUROENDOCRINOLOGY GASTROENTEROLOGY GASTROENTEROLOGYGASTROINTEST ENDOSC GASTROINTESTINAL ENDOSCOPYGUT GUTHEPATOLOGY HEPATOLOGYHUM MUTAT HUMAN MUTATIONHUM REPROD UPDATE HUMAN REPRODUCTION UPDATEHYPERTENSION HYPERTENSIONIMMUNITY IMMUNITYIMMUNOL REV IMMUNOLOGICAL REVIEWSJ ALLERGY CLIN IMMUN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGYJ AM COLL CARDIOL JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGYJ AM SOC NEPHROL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYJ AUTOIMMUN JOURNAL OF AUTOIMMUNITYJ BONE MINER RES JOURNAL OF BONE AND MINERAL RESEARCHJ CLIN INVEST JOURNAL OF CLINICAL INVESTIGATIONJ CLIN ONCOL JOURNAL OF CLINICAL ONCOLOGYJ EXP MED JOURNAL OF EXPERIMENTAL MEDICINEJ HEPATOL JOURNAL OF HEPATOLOGYJ NATL CANCER I JOURNAL OF THE NATIONAL CANCER INSTITUTEJ NEUROSCI JOURNAL OF NEUROSCIENCEJ NUCL MED JOURNAL OF NUCLEAR MEDICINEJAMA-J AM MED ASSOC JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LANCET LANCETLANCET INFECT DIS LANCET INFECTIOUS DISEASESLANCET NEUROL LANCET NEUROLOGYLANCET ONCOL LANCET ONCOLOGYLEUKEMIA LEUKEMIAMED RES REV MEDICINAL RESEARCH REVIEWSMOL ASPECTS MED MOLECULAR ASPECTS OF MEDICINEMOL PSYCHIATR MOLECULAR PSYCHIATRYNAT CLIN PRACT ONCOL Nature Clinical Practice OncologyNAT IMMUNOL NATURE IMMUNOLOGYNAT MED NATURE MEDICINENAT NEUROSCI NATURE NEUROSCIENCENAT REV CANCER NATURE REVIEWS CANCERNAT REV DRUG DISCOV NATURE REVIEWS DRUG DISCOVERYNAT REV IMMUNOL NATURE REVIEWS IMMUNOLOGYNAT REV NEUROSCI NATURE REVIEWS NEUROSCIENCENEUROLOGY NEUROLOGYNEURON NEURONNEUROPSYCHOPHARMACOL NEUROPSYCHOPHARMACOLOGYNEUROSCI BIOBEHAV R NEUROSCIENCE AND BIOBEHAVIORAL REVIEWSNEW ENGL J MED NEW ENGLAND JOURNAL OF MEDICINEOBES REV Obesity ReviewsONCOGENE ONCOGENEPHARMACOL REV PHARMACOLOGICAL REVIEWSPHARMACOL THERAPEUT PHARMACOLOGY & THERAPEUTICSPHYSIOL REV PHYSIOLOGICAL REVIEWSPHYSIOLOGY PHYSIOLOGYPLOS MED PLOS MEDICINEPROG NEUROBIOL PROGRESS IN NEUROBIOLOGYPROG RETIN EYE RES PROGRESS IN RETINAL AND EYE RESEARCHPSYCHOL BULL PSYCHOLOGICAL BULLETINPSYCHOL REV PSYCHOLOGICAL REVIEWREV MED VIROL REVIEWS IN MEDICAL VIROLOGYSCHIZOPHRENIA BULL SCHIZOPHRENIA BULLETINSEMIN CANCER BIOL SEMINARS IN CANCER BIOLOGYSEMIN IMMUNOL SEMINARS IN IMMUNOLOGYSTEM CELLS STEM CELLSSTROKE STROKETHORAX THORAXTRENDS COGN SCI TRENDS IN COGNITIVE SCIENCESTRENDS ENDOCRIN MET TRENDS IN ENDOCRINOLOGY AND METABOLISMTRENDS IMMUNOL TRENDS IN IMMUNOLOGYTRENDS MOL MED TRENDS IN MOLECULAR MEDICINETRENDS NEUROSCI TRENDS IN NEUROSCIENCESTRENDS PHARMACOL SCI TRENDS IN PHARMACOLOGICAL SCIENCESWHO TECH REP SER WHO TECHNICAL REPORT SERIESAM J CARDIOL AMERICAN JOURNAL OF CARDIOLOGYAM J EPIDEMIOL AMERICAN JOURNAL OF EPIDEMIOLOGYAM J PATHOL AMERICAN JOURNAL OF PATHOLOGYAM J PHYSIOL-HEART C AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULA ANTIMICROB AGENTS CH ANTIMICROBIAL AGENTS AND CHEMOTHERAPYBRIT J CANCER BRITISH JOURNAL OF CANCERCANCER-AM CANCER SOC CANCERCHEST CHESTCNS NEUROL DISORD-DR CNS & Neurological Disorders-Drug Targets ENDOCRINOLOGY ENDOCRINOLOGYEUR J NEUROSCI EUROPEAN JOURNAL OF NEUROSCIENCEFREE RADICAL BIO MED FREE RADICAL BIOLOGY AND MEDICINEINFECT IMMUN INFECTION AND IMMUNITYINT J CANCER INTERNATIONAL JOURNAL OF CANCERINT J RADIAT ONCOL INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOL INVEST OPHTH VIS SCI INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEJ APPL PHYSIOL JOURNAL OF APPLIED PHYSIOLOGYJ CLIN ENDOCR METAB JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM J CLIN MICROBIOL JOURNAL OF CLINICAL MICROBIOLOGYJ COMP NEUROL JOURNAL OF COMPARATIVE NEUROLOGYJ IMMUNOL JOURNAL OF IMMUNOLOGYJ INFECT DIS JOURNAL OF INFECTIOUS DISEASESJ MED CHEM JOURNAL OF MEDICINAL CHEMISTRYJ NEUROCHEM JOURNAL OF NEUROCHEMISTRYJ NEUROPHYSIOL JOURNAL OF NEUROPHYSIOLOGYJ NUTR JOURNAL OF NUTRITIONJ PHARMACOL EXP THER JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPE J PHYSIOL-LONDON JOURNAL OF PHYSIOLOGY-LONDONJ UROLOGY JOURNAL OF UROLOGYJ VIROL JOURNAL OF VIROLOGYKIDNEY INT KIDNEY INTERNATIONALNEUROIMAGE NEUROIMAGENEUROSCIENCE NEUROSCIENCEPEDIATRICS PEDIATRICSRADIOLOGY RADIOLOGYTRANSPLANTATION TRANSPLANTATIONVIROLOGY VIROLOGYNATURE NATUREP NATL ACAD SCI USA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES SCIENCE SCIENCEANN NY ACAD SCI ANNALS OF THE NEW YORK ACADEMY OF SCIENCESISSN大类名称复分大类分区是否top期刊2009年影响因子1680-7316地学1Y 4.881 0003-0007地学1Y 6.123 0930-7575地学1Y 3.917 0010-7999地学1Y 3.497 0012-821X地学1Y 4.062 0012-8252地学1Y 6.942 0016-7037地学1Y 4.385 0091-7613地学1Y 4.368 0266-1144地学1Y 4.039 0894-8755地学1Y 3.363 0022-3530地学1Y 3.738 0024-3590地学1Y 3.545 1752-0894地学1Y8.108 0883-8305地学1Y 3.644 0301-9268地学1Y 3.574 0277-3791地学1Y 4.245 8755-1209地学1Y8.021 0094-8276地学2Y 3.204 0022-4928地学2Y 2.911 0148-0227地学2Y 3.082 0022-1694地学2Y 2.433 0027-0644地学2Y 2.238 0066-4146地学天文1Y25.640 0935-4956地学天文1Y11.857 0067-0049地学天文1Y12.771 0004-637X地学天文2Y7.364 0360-0300工程技术1Y7.667 0730-0301工程技术1Y 3.619 1936-0851工程技术1Y7.493 1742-7061工程技术1Y 3.975 1359-6454工程技术1Y 3.760 0065-2156工程技术1Y 5.500 0724-6145工程技术1Y 4.165 1616-301X工程技术1Y 6.990 0935-9648工程技术1Y8.379 1523-9829工程技术1Y11.235 1531-7331工程技术1Y7.911 0570-4928工程技术1Y 3.243 0004-3702工程技术1Y 3.036 0142-9612工程技术1Y7.365 0960-8524工程技术1Y 4.253 0956-5663工程技术1Y 5.429 0734-9750工程技术1Y8.250 0006-3592工程技术1Y 3.377 1754-6834工程技术1Y 4.118 0008-6223工程技术1Y 4.5040897-4756工程技术1Y 5.368 0824-7935工程技术1Y 5.378 0738-8551工程技术1Y 3.567 1040-8398工程技术1Y 3.725 0958-1669工程技术1Y7.820 1388-2481工程技术1Y 4.243 0737-0024工程技术1Y 6.190 0733-8716工程技术1Y 3.758 1053-5888工程技术1Y 4.914 1089-778X工程技术1Y 4.589 0278-0046工程技术1Y 4.678 1045-9227工程技术1Y 2.889 0162-8828工程技术1Y 4.378 0098-5589工程技术1Y 3.750 0920-5691工程技术1Y 3.508 0360-3199工程技术1Y 3.945 1565-1339工程技术1Y 5.276 0749-6419工程技术1Y 4.791 0950-6608工程技术1Y 4.857 0021-9517工程技术1Y 5.288 0304-3894工程技术1Y 4.144 0959-9428工程技术1Y 4.795 1751-6161工程技术1Y 3.176 1741-2560工程技术1Y 3.739 0378-7753工程技术1Y 3.792 1570-8268工程技术1Y 3.412 1473-0197工程技术1Y 6.306 1022-1336工程技术1Y 4.263 0024-9297工程技术1Y 4.539 0927-796X工程技术1Y12.217 1369-7021工程技术1Y11.452 1361-8415工程技术1Y 3.093 1096-7176工程技术1Y 4.725 0276-7783工程技术1Y 4.485 1613-4125工程技术1Y 4.356 0883-7694工程技术1Y 6.330 1530-6984工程技术1Y9.991 1748-0132工程技术1Y13.237 1549-9634工程技术1Y 5.440 0957-4484工程技术1Y 3.137 1087-0156工程技术1Y29.495 1476-1122工程技术1Y29.504 1748-3387工程技术1Y26.309 1566-1199工程技术1Y 3.262 0018-9219工程技术1Y 4.878 1557-1955工程技术1Y 3.723 1558-3724工程技术1Y 5.6120960-8974工程技术1Y9.250 0360-1285工程技术1Y11.024 0079-6425工程技术1Y15.769 1062-7995工程技术1Y 4.702 0079-6727工程技术1Y 4.091 0079-6816工程技术1Y7.913 1364-0321工程技术1Y 4.842 1613-6810工程技术1Y 6.171 1744-683X工程技术1Y 4.869 0167-7799工程技术1Y 6.909 0924-2244工程技术1Y 4.051 1066-8888工程技术1Y 4.517 0001-1541工程技术2Y 1.955 0175-7598工程技术2Y 2.896 0009-2509工程技术2Y 2.136 0013-4686工程技术2Y 3.325 0308-8146工程技术2Y 3.146 0018-926X工程技术2Y 2.011 0018-9286工程技术2Y 2.556 0018-9448工程技术2Y 2.357 0018-9480工程技术2Y 2.076 1053-587X工程技术2Y 2.212 0888-5885工程技术2Y 1.758 0017-9310工程技术2Y 1.947 0002-7820工程技术2Y 1.944 0013-4651工程技术2Y 2.241 0376-7388工程技术2Y 3.203 0167-577X工程技术2Y 1.940 1359-6462工程技术2Y 2.949 0925-4005工程技术2Y 3.083 0257-8972工程技术2Y 1.793 0379-6779工程技术2Y 1.901 0040-6090工程技术2Y 1.727 0272-6963管理科学1Y 3.238 0025-1909管理科学1Y 2.227 0305-0483管理科学1Y 3.101 1059-1478管理科学1Y 2.080 0377-2217管理科学2Y 2.093 0001-4842化学1Y18.203 0108-7673化学化学－晶体1Y49.926 0002-5100化学1Y18.688 1433-7851化学1Y11.829 0066-426X化学1Y17.464 0161-4940化学1Y7.765 0009-2665化学1Y35.957 0306-0012化学1Y20.086 0010-8545化学1Y11.2251754-5692化学1Y8.500 0144-235X化学1Y 5.000 0002-7863化学1Y8.580 1389-5567化学1Y7.952 0265-0568化学1Y9.202 0079-6700化学1Y23.753 0167-5729化学1Y13.462 0165-9936化学1Y 6.546 0003-2700化学2Y 5.214 0022-3263化学2Y 4.219 1520-6106化学2Y 3.471 0743-7463化学2Y 3.898 0926-3373环境科学1Y 5.252 0003-0090环境科学1Y 4.133 1064-3389环境科学1Y7.091 1461-023X环境科学1Y10.318 0012-9615环境科学1Y 4.862 0012-9658环境科学1Y 4.411 0091-6765环境科学1Y 6.191 1462-2912环境科学1Y 4.909 0014-3820环境科学1Y 5.429 1540-9295环境科学1Y 6.922 1354-1013环境科学1Y 5.561 1466-822X环境科学1Y 5.913 1751-7362环境科学1Y 6.397 1352-2310环境科学2Y 3.139 0045-6535环境科学2Y 3.253 0013-936X环境科学2Y 4.630 0043-1354环境科学2Y 4.355 0065-2113农林科学1Y 3.800 0168-1923农林科学1Y 3.197 0261-1929农林科学1Y 1.580 1351-0754农林科学1Y 2.131 1467-2960农林科学1Y 4.489 1054-6006农林科学1Y 2.427 1050-4648农林科学1Y 2.892 1935-5130农林科学1Y 2.238 0016-7061农林科学1Y 2.461 1084-2020农林科学1Y 2.806 0021-8561农林科学1Y 2.469 0021-8812农林科学1Y 2.466 0022-0302农林科学1Y 2.463 1380-3743农林科学1Y 2.272 0960-3166农林科学1Y 2.161 0038-0717农林科学1Y 2.978 0361-5995农林科学1Y 2.179 0829-318X农林科学1Y 2.2920378-1135农林科学1Y 2.874 0928-4249农林科学1Y 3.579 0044-8486农林科学2Y 1.925 0706-652X农林科学2Y 1.951 0378-1127农林科学2Y 1.950 0003-1488农林科学2Y 1.714 0032-079X农林科学2Y 2.517 1526-5161社会科学1Y 4.000 0012-9682社会科学1Y 4.000 0304-4076社会科学2Y 1.902 0002-9297生物1Y12.303 0066-4154生物1Y29.875 1056-8700生物1Y18.955 1936-122X生物1Y19.304 1081-0706生物1Y19.571 1543-592X生物1Y8.190 0066-4170生物1Y11.271 0066-4197生物1Y13.235 1527-8204生物1Y11.568 0066-4227生物1Y12.804 0066-4286生物1Y11.212 1543-5008生物1Y23.460 0092-8674生物1Y31.152 1931-3128生物1Y13.021 1550-4131生物1Y17.350 1934-5909生物1Y23.563 1040-9238生物1Y10.216 0960-9822生物1Y10.992 0955-0674生物1Y14.153 0959-437X生物1Y8.987 1369-5266生物1Y10.333 0959-440X生物1Y9.344 1534-5807生物1Y13.363 0890-9369生物1Y12.075 1088-9051生物1Y11.342 0021-9525生物1Y9.575 1092-2172生物1Y12.585 1097-2765生物1Y14.608 1744-4292生物1Y12.125 1465-7392生物1Y19.527 1552-4450生物1Y16.058 1061-4036生物1Y34.284 1548-7091生物1Y16.874 1471-0056生物1Y27.822 1740-1526生物1Y17.644 1471-0072生物1Y42.198 1545-9985生物1Y12.2731040-4651生物1Y9.293 1544-9173生物1Y12.916 1553-7390生物1Y9.532 1553-7366生物1Y8.978 0163-7827生物1Y8.167 0033-5835生物1Y10.200 0968-0004生物1Y11.572 0962-8924生物1Y12.115 0169-5347生物1Y11.564 0168-9525生物1Y8.689 1360-1385生物1Y9.883 0099-2240生物2Y 3.686 0264-6021生物2Y 5.155 0006-3495生物2Y 4.390 0950-1991生物2Y7.194 0261-4189生物2Y8.993 0021-9193生物2Y 3.940 0021-9258生物2Y 5.328 0022-2836生物2Y 3.871 0270-7306生物2Y 6.057 0305-1048生物2Y7.479 0032-0889生物2Y 6.235 0001-5962数学1Y 2.619 0003-486X数学1Y 4.174 0090-5364数学1Y 3.185 0273-0979数学1Y 3.294 0010-3640数学1Y 2.657 1615-3375数学1Y 1.905 0020-9910数学1Y 2.794 0266-5611数学1Y 1.900 0894-0347数学1Y 3.411 0162-1459数学1Y 2.322 1369-7412数学1Y 3.473 0218-2025数学1Y 2.095 0025-5610数学1Y 2.048 0065-9266数学1Y 2.240 1540-3459数学1Y 2.198 0027-3171数学1Y 2.328 1468-1218数学1Y 2.381 0272-4332数学1Y 1.953 0036-1445数学1Y 3.391 0883-4237数学1Y 3.523 1070-5511数学1Y 3.153 0165-0114数学2Y 2.138 0377-0427数学2Y 1.292 0022-0396数学2Y 1.426 0022-247X数学2Y 1.2250362-546X数学2Y 1.487 0036-1429数学2Y 1.840 1064-8275数学2Y 1.595 0108-7673物理物理－晶体1Y49.926 0001-8732物理1Y19.632 0066-4189物理1Y9.353 0163-8998物理1Y11.964 1040-8436物理1Y 5.167 1126-6708物理1Y 6.019 1863-8880物理1Y 5.814 1433-8351物理1Y10.600 0277-7037物理1Y10.623 1749-4885物理1Y22.869 1745-2473物理1Y15.491 0370-1573物理1Y17.752 0031-9007物理1Y7.328 0079-6565物理1Y 6.742 0034-4885物理1Y11.444 0034-6861物理1Y33.145 0003-6951物理2Y 3.554 0021-9606物理2Y 3.093 1098-0121物理2Y 3.475 1550-7998物理2Y 4.922 0169-409X医学1Y11.957 0065-2776医学1Y7.725 0002-9165医学1Y 6.307 0002-9270医学1Y 6.012 0002-953X医学1Y12.522 1073-449X医学1Y10.689 1600-6135医学1Y 6.433 0003-4819医学1Y16.225 0364-5134医学1Y9.317 0003-4967医学1Y8.111 0003-4932医学1Y7.900 0732-0582医学1Y37.902 0066-4219医学1Y9.940 0147-006X医学1Y24.822 0199-9885医学1Y8.783 1553-4006医学1Y13.500 0362-1642医学1Y22.468 0066-4278医学1Y18.170 0066-4308医学1Y22.750 0163-7525医学1Y7.915 0003-990X医学1Y12.257 0003-9926医学1Y9.813 1079-5642医学1Y7.235 0004-3591医学1Y7.332。
神经酰胺合成分解途径中的抑制剂在制备埃博拉病毒疾病药物中的应用[发明专利]
![神经酰胺合成分解途径中的抑制剂在制备埃博拉病毒疾病药物中的应用[发明专利]](https://img.taocdn.com/s3/m/0ef34776b207e87101f69e3143323968001cf457.png)
(19)国家知识产权局(12)发明专利申请(10)申请公布号 (43)申请公布日 (21)申请号 202210275759.5(22)申请日 2022.03.21(71)申请人 安徽大学地址 230000 安徽省合肥市肥西路3号(72)发明人 王迪 刘萱 张部昌 徐昌志 (74)专利代理机构 合肥中谷知识产权代理事务所(普通合伙) 34146专利代理师 袁锦波(51)Int.Cl.A61K 31/265(2006.01)A61K 31/225(2006.01)A61P 31/14(2006.01)(54)发明名称神经酰胺合成分解途径中的抑制剂在制备埃博拉病毒疾病药物中的应用(57)摘要本发明属于生物医药领域，特别涉及神经酰胺合成分解途径中的抑制剂在制备预防或治疗埃博拉病毒疾病的药物中的应用，本发明通过加入神经酰胺合成分解相关的抑制剂‑D 609、Fumonisin B1导致埃博拉病毒在细胞中形成的包涵体的数量减少、体积下降，还可以阻碍包涵体的成熟，显著抑制埃博拉病毒在细胞中的增殖。
本文探索了在神经酰胺轴中以鞘磷脂合酶抑制剂D609、神经酰胺合成酶抑制剂Fumonisin B1为代表的小分子化合物在埃博拉病毒病治疗中的潜力，为其在临床上用于防治埃博拉病毒提供了新的依据，在埃博拉的治疗领域将有广阔的应用前景。
权利要求书1页 说明书5页 附图2页CN 114452278 A 2022.05.10C N 114452278A1.神经酰胺合成分解途径中的抑制剂在制备预防或治疗埃博拉病毒疾病的药物中的应用。
2.根据权利要求1所述的神经酰胺合成分解途径中的抑制剂在制备预防或治疗埃博拉病毒疾病的药物中的应用，其特征在于，通过加入神经酰胺合成分解途径中的抑制剂导致埃博拉病毒在细胞中形成的包涵体的数量减少、体积下降，阻碍包涵体的成熟，显著抑制埃博拉病毒在细胞中的增殖。
3.根据权利要求1所述的神经酰胺合成分解途径中的抑制剂在制备预防或治疗埃博拉病毒相关疾病的药物中的应用，其特征在于，所述预防或治疗埃博拉病毒相关疾病的药物指如下X1)‑X5)中任一种：X1)制备用于预防或治疗埃博拉病毒感染的药物；X2)制备用于预防或治疗埃博拉病毒所致疾病的药物；X3)制备用于抑制埃博拉病毒复制增殖的药物；X4)制备用于抑制埃博拉病毒产生细胞病变效应的药物；X5)制备埃博拉病毒抑制剂。
Ang-1模拟肽协同血管内皮生长因子对心肌梗死大鼠心脏功能的影响
o
t
i
n
-mod
i
f
i
edAMP (
B
i
o
-AMP)t
oc
-ECM wa
st
e
s
t
ed.A myo
c
a
r
d
i
a
li
n
f
a
r
c
t
i
onmode
lwa
se
s
-
t
ab
l
i
shedbyl
i
t
i
ono
ft
hel
e
f
tan
t
e
r
i
o
rde
s
c
end
i
nga
r
t
e
r
nSD r
a
t
s.Ther
a
t
swe
r
er
andoml
Copyright©博看网. All Rights Reserved.
精准医学杂志 2023 年 8 月第 38 卷第 4 期 JPr
e
c
i
sMed,Augus
t2023,Vo
l.
38,No.
4
足会导致心肌细胞 死 亡 和 病 理 性 重 塑,进 一 步 发 展
为心力衰竭
。促血管生成治疗是指通过形成新生
Ang
1)在后期
能够募集血管周细胞和平滑肌细胞,因此 Ang
1能
有效促进血 管 的 成 熟
。Ang
1模拟肽(
AMP)为
[
11]
一段来源于 Ang
高尔基体概述
高尔基体概述高尔基体（Golgi apparatus）是由许多扁平的囊泡构成的以分泌为主要功能的细胞器。
又称高尔基器或高尔基复合体；在高等植物细胞中称分散高尔基体。
最早发现于1855年，1898年由意大利人卡米洛•高尔基（Camillo Golgi，1844-1926）在光学显微镜下研究银盐浸染的猫头鹰神经细胞内观察到了清晰的结构，因此定名为高尔基体。
因为这种细胞器的折射率与细胞质基质很相近，所以在活细胞中不易看到。
高尔基体从发现至今已有100多年的历史，其中一半以上的时间是进行关于高尔基体的形态甚至是它是否真实存在的争论。
细胞学家赋予它几十种不同的名称，也有很多人认为高尔基体是由于固定和染色而产生的人工假像。
直到20世纪50年代应用电子显微镜才清晰地看出它的亚显微结构。
它不仅存在于动植物细胞中，而且也存在于原生动物和真菌细胞内。
形态与组成高尔基体是由数个扁平囊泡堆在一起形成的高度有极性的细胞器。
常分布于内质网与细胞膜之间，呈弓形或半球形，凸出的一面对着内质网称为形成面（forming face）或顺面（cis face）。
凹进的一面对着质膜称为成熟面（mature face）或反面（trans face）。
顺面和反面都有一些或大或小的运输小泡，在具有极性的细胞中，高尔基体常大量分布于分泌端的细胞质中。
顺面和反面都有一些或大或小的运输小泡（图6-24），在具有极性的细胞中，高尔基体常大量分布于分泌端的细胞质中（图6-25）。
图6-24高尔基体各部分的名称图6-25培养的上皮细胞中高尔基体的分布（高尔基体为红色，核为绿色）引自/因其看上极像滑面内质网，因此有科学家认为它是由滑面内质网进化而来的。
扁平囊的直径为1μm，由单层膜构成，膜厚6~7nm，中间形成囊腔，周缘多呈泡状，4~8个扁平囊在一起，某些藻类可达一二十个，构成高尔基体的主体，称为高尔基堆（Golgi stack）。
高尔基体膜含有大约60%的蛋白和40%的脂类，具有一些和ER共同的蛋白成分。
《临床肝胆病杂志》推荐使用的规范医学名词术语
临床肝胆病杂志第40卷第3期2024年3月J Clin Hepatol， Vol.40 No.3， Mar.2024[3]XIA SL, LIU ZM, CAI JR, et al. Liver fibrosis therapy based on biomi⁃metic nanoparticles which deplete activated hepatic stellate cells[J]. J Control Release, 2023, 355: 54-67. DOI: 10.1016/j.jconrel.2023.01.052.[4]LIU YW, DONG YT, WU XJ, et al. The assessment of mesenchymalstem cells therapy in acute on chronic liver failure and chronic liver disease: A systematic review and meta-analysis of randomized con⁃trolled clinical trials[J]. Stem Cell Res Ther, 2022, 13(1): 204. DOI:10.1186/s13287-022-02882-4.[5]ZHANG ZL, SHANG J, YANG QY, et al. Exosomes derived from hu⁃man adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline me⁃tabolism[J]. J Nanobiotechnology, 2023, 21(1): 29. DOI: 10.1186/ s12951-023-01788-4.[6]ZHAO T, SU ZP, LI YC, et al. Chitinase-3 like-protein-1 function andits role in diseases[J]. Signal Transduct Target Ther, 2020, 5(1): 201. DOI: 10.1038/s41392-020-00303-7.[7]YANG H, ZHAO LL, HAN P, et al. Value of serum chitinase-3-likeprotein 1 in predicting the risk of decompensation events in patients with liver cirrhosis[J]. J Clin Hepatol, 2023, 39(7): 1578-1585. DOI:10.3969/j.issn.1001-5256.2023.07.011.杨航, 赵黎莉, 韩萍, 等. 血清壳多糖酶3样蛋白1(CHI3L1)对肝硬化患者发生失代偿事件风险的预测价值[J]. 临床肝胆病杂志, 2023, 39(7): 1578-1585. DOI: 10.3969/j.issn.1001-5256.2023.07.011.[8]MA L, WEI J, ZENG Y, et al. Mesenchymal stem cell-originated exo⁃somal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis[J]. Drug Deliv, 2022, 29(1): 440-453. DOI: 10.1080/10717544.2022.2030428. [9]NISHIMURA N, DE BATTISTA D, MCGIVERN DR, et al. Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis[J]. Proc Natl Acad Sci U S A, 2021, 118(17): e2019633118. DOI: 10.1073/pnas.2019633118.[10]WANG CG, LI SZ, SHI JM, et al. Research progress in differentia⁃tion, identification, and purification methods of human pluripotent stem cells to mesenchymal-like cells in vitro[J]. J Jilin Univ Med Ed, 2023, 49(6): 1655-1661. DOI: 10.13481/j.1671-587X.20230634.王成刚, 李生振, 史嘉敏, 等. 体外人多能干细胞向间充质样细胞分化、鉴定和纯化方法的研究进展[J]. 吉林大学学报(医学版), 2023, 49(6): 1655-1661. DOI: 10.13481/j.1671-587X.20230634.[11]LI TT, WANG ZR, YAO WQ, et al. Stem cell therapies for chronicliver diseases: Progress and challenges[J]. Stem Cells Transl Med, 2022, 11(9): 900-911. DOI: 10.1093/stcltm/szac053.[12]YANG X, LI Q, LIU WT, et al. Mesenchymal stromal cells in hepaticfibrosis/cirrhosis: From pathogenesis to treatment[J]. Cell Mol Im⁃munol, 2023, 20(6): 583-599. DOI: 10.1038/s41423-023-00983-5. [13]ZHAO SX, LIU Y, PU ZH. Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apop⁃tosis by activating autophagy in vitro[J]. Drug Des Devel Ther, 2019, 13: 2887-2897. DOI: 10.2147/DDDT.S220190.[14]LEE CG, HARTL D, LEE GR, et al. Role of breast regression protein39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue re⁃sponses and apoptosis[J]. J Exp Med, 2009, 206(5): 1149-1166.DOI: 10.1084/jem.20081271.[15]HIGASHIYAMA M, TOMITA K, SUGIHARA N, et al. Chitinase 3-like 1deficiency ameliorates liver fibrosis by promoting hepatic macro⁃phage apoptosis[J]. Hepatol Res, 2019, 49(11): 1316-1328. DOI:10.1111/hepr.13396.收稿日期：2023-06-09；录用日期：2023-08-17本文编辑：邢翔宇引证本文：LIU PJ, YAO LC, HU X, et al. Effect of human umbilical cord mesenchymal stem cells in treatment of mice with liver fibrosis and its mechanism[J]. J Clin Hepatol, 2024, 40(3): 527-532.刘平箕, 姚黎超, 胡雪, 等. 人脐带间充质干细胞(hUC-MSC)对肝纤维化小鼠模型的治疗作用及其机制分析[J]. 临床肝胆病杂志, 2024, 40(3): 527-532.读者·作者·编者《临床肝胆病杂志》推荐使用的规范医学名词术语有关名词术语应规范统一，以全国自然科学名词审定委员会公布的各学科名词为准。
实时剪切波弹性成像在拉米夫定治疗乙肝纤维化过程中的疗效评估作用
实时剪切波弹性成像在拉米夫定治疗乙肝纤维化过程中的疗效评估作用1. 引言1.1 疾病背景介绍乙肝是一种由乙型肝炎病毒引起的肝炎，是全球范围内的公共卫生问题。
乙肝病毒通过血液、性接触及母婴传播等途径感染，引起急性或慢性肝炎，严重的情况可能演变为肝硬化及肝癌。
根据世界卫生组织的数据，全球约有2亿人携带乙肝病毒感染，其中约有2400万人患有慢性乙型肝炎，导致年均有78万人死于乙肝相关疾病。
乙肝患者在长期感染乙型肝炎病毒后，可出现肝组织纤维化的现象。
肝纤维化是肝脏受损后的一种生理反应，也是肝硬化和肝癌的前兆。
在乙肝相关疾病中，纤维化程度的评估对于治疗方案的选择和疗效的监测至关重要。
1.2 拉米夫定治疗乙肝纤维化乙肝是一种由乙型肝炎病毒引起的慢性肝炎疾病，其长期进展可能导致肝脏纤维化、肝硬化甚至肝癌等严重并发症。
而纤维化是肝脏受损后的一种生理反应，其主要特征是肝脏组织中纤维蛋白过多增生，导致肝脏结构和功能受损。
乙肝患者也常伴随肝脏纤维化的发展，因此抑制纤维化的进程对于预防肝脏疾病的恶化至关重要。
拉米夫定是一种核苷酸类似物，被广泛应用于乙肝病毒感染的治疗中。
研究表明，拉米夫定能够有效地抑制乙肝病毒的复制，减少肝脏炎症反应，从而延缓疾病的进展。
一些研究还显示，拉米夫定治疗也对纤维化程度有一定的影响。
通过减少病毒复制，降低肝脏炎症，可以减缓纤维化的发展，并有可能逆转早期的纤维化病变。
1.3 实时剪切波弹性成像技术简介实时剪切波弹性成像（Real-time Shear Wave Elastography）是一种无创的医学影像检测技术，通过将声波作用于组织并观察组织对声波的反应来评估组织的硬度。
这项技术可以实时、快速地获取组织的弹性信息，为医生提供了有关组织结构和功能的重要信息。
实时剪切波弹性成像利用超声波探头在人体组织中产生一种称为切割波的机械波，并通过实时跟踪这些波的传播速度来计算组织的弹性模量。
通过测量组织的弹性特性，可以帮助医生评估组织的健康状态，例如乙肝患者的肝脏纤维化程度。