B3U2P6

合集下载

杀菌剂配方

甲醛释放型防腐剂，但游离甲醛含量低，应用pH范围2-12
??百杀得CI-14
14%CMIT/MIT
0.02-0.8%
对真菌、细菌、霉菌及酶菌都有很好的抑制能力，用量低，无气味，不产生颜色变化，毒性低，易操作。
使用环境pH＜9，与硫化物和胺类有配伍反应，该产品贮存温度＜40度
?? ??百杀得MIT-20
20%MIT
0.2-1%
?? ??百杀得BIT-20D
BIT分散体（20%）
0.05-0.4%
对胺类化合物稳定，不含甲醛,无VOC。
在碱性条件下十分稳定，耐高温。
?? ??百杀得BIT-20
BIT（20%）
0.05-0.4%
对胺类化合物稳定，不含甲醛。
碱性条件下十分稳定，耐高温。
?? ??百杀得MIT-20
MIT（20%）
?? ??百杀得MIT-S
MIT（99%）
0.03-0.3%
杀菌广谱长效，可用于pH2-12的体系中，不含甲醛
没有局限性，并对氧化、还原剂稳定
?? ??百杀得BBC
BRONOPOL等
0.02-0.1%
具有复合防腐剂的所有优点，杀菌广谱、长效
pH范围2-8有效
?? ??百杀得BBD
BRONOPOL等
0.02-0.1%
具有复合防腐剂的所有优点，杀菌广谱、长效
pH范围2-8有效
?? ??百杀得BQI
IPBCand1227等（35%）
0.05-0.3%
具有复合防腐剂的所有优点，杀菌广谱、长效
pH范围4-10有效
?? ??百杀得DB
DMDM，BIT等
0.05-0.6%
具有复合防腐剂的所有优点，杀菌广谱、长效

Mirogabalin besylate (DS 5565 besylate) 1138245-21-2 GlpBio

Product Data SheetProduct Name:Mirogabalin besylate (DS 5565 besylate)Cat. No.:GC30961Chemical PropertiesCas No.1138245-21-2ChemicalNameN/ACanonicalSMILESO=S(C1=CC=CC=C1)(O)=O.OC(C[C@@]2([C@@]3([H])[C@@](CC(CC)=C3)([H])C2)CN)=O Formula C18H25NO5S M.Wt367.46Solubility DMSO : 125 mg/mL (340.17 mM;Need ultrasonic)Storage Store at -20°CGeneral tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request.StructureBackgroundMirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels,Product Data Sheetwith Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.Mirogabalin besylate is a ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. Mirogabalin shows binding aﬃnity for the gabapentin binding site in rat cortical brain homogenates with the IC50 value of 16.0 nM. Mirogabalin has no eﬀect on any other receptors, channels, transporters, or enzymes at 50 μM[1].Mirogabalin besylate (3 and 10 mg/kg) markedly increases AUC0-8 hours values in a dose-dependent manner in partial sciatic nerve ligation model rats. Mirogabalin (2.5, 5, and 10 mg/kg) causes signiﬁcant and dose-dependent increase in AUC0-12 hours values and enhances analgesic eﬀects, with estimated ED50 of 4.4, 3.1, and <2.5 mg/kg on day 1, day 3, and day 5, respectively. Moreover, Mirogabalin besylate shows no obvious eﬀect on rota-rod performance and locomotor activity at 3 and 10 mg/kg via oral administration, exhibits signiﬁcant inhibition on rota-rod performance at 10, 30, and 100 mg/kg, and decreases locomotor activity at 30 and 100 mg/kg in rats[1]. [1]. Domon Y, et al. Binding Characteristics and Analgesic Eﬀects of Mirogabalin, a Novel Ligand for the α2δ Subunit of Voltage-Gated Calcium Channels. J Pharmacol Exp Ther. 2018 Jun;365(3):573-582.。

USP60

USP60USP60 (Ubiquitin Specific Peptidase 60) is a deubiquitinating enzyme that plays a crucial role in cellular processes such as protein degradation, DNA repair, and cell cycle regulation. In this document, we will explore the structure, function, and regulatory mechanisms of USP60.Structure of USP60USP60 is a member of the ubiquitin-specific protease family. It consists of several distinct domains that contribute to its enzymatic activity and substrate specificity. The catalytic domain of USP60 contains a conserved cysteine residue that mediates the cleavage of the isopeptide bond between ubiquitin and its target protein. Adjacent to the catalytic domain, there is a ZnF-UBP domain that helps in substrate recognition and binding. The C-terminal domain of USP60 is responsible for its stability and localization within the cell.Function of USP60USP60 primarily functions as a deubiquitinating enzyme, deconjugating ubiquitin molecules from target proteins. By removing ubiquitin chains, USP60 can prevent the degradation of target proteins by the proteasome, thereby stabilizing them. Additionally, USP60 regulates the levels of ubiquitin by recycling ubiquitin molecules back into the cytoplasm for further use.USP60 is also involved in DNA repair processes. It interacts with various DNA repair proteins, such as BRCA1 and RAD51,and helps in the removal of ubiquitin moieties from DNA repair complexes. This activity of USP60 ensures efficient DNA damage repair and maintenance of genomic stability.Furthermore, USP60 has been implicated in cell cycle regulation. It interacts with cell cycle regulators, such as p53 and CDC25C, and modulates their stability and activity. This regulation of cell cycle progression by USP60 is essential for proper cell division and prevention of aberrant cell growth.Regulation of USP60 ActivityThe activity of USP60 is regulated by various mechanisms, including post-translational modifications, protein-protein interactions, and subcellular localization. One of the key regulatory mechanisms is phosphorylation. Phosphorylation of specific residues within USP60 can either enhance or inhibit its enzymatic activity. For example, phosphorylation of USP60 by ATM kinase increases its activity and promotes DNA repair.USP60 can also interact with other proteins, forming complexes that modulate its activity. For instance, interaction with BRCA1 enhances the deubiquitinating activity of USP60 in DNA repair processes. On the other hand, interaction with negative regulators such as UAF1 can inhibit the function of USP60.Subcellular localization of USP60 is crucial for its proper function. It is primarily localized in the nucleus, where it interacts with DNA repair and cell cycle proteins. However, under certain cellular stress conditions, USP60 can translocate to the cytoplasm and participate in other cellular processes.Role of USP60 in DiseaseDysregulation of USP60 function has been associated with various diseases. For example, aberrant expression or activity of USP60 has been observed in certain types of cancer. In some cases, overexpression of USP60 can stabilize oncoproteins and promote tumor growth. In other cases, downregulation of USP60 can impair DNA repair mechanisms, leading to genomic instability and increased cancer susceptibility.Furthermore, mutations in the USP60 gene have been associated with neurodegenerative disorders. These mutations can lead to a loss of USP60 function, resulting in the accumulation of abnormal proteins and neuronal cell death.ConclusionUSP60 is a versatile deubiquitinating enzyme that has important roles in protein degradation, DNA repair, and cell cycle regulation. Its structure, function, and regulatory mechanisms make it an attractive target for therapeutic interventions in various diseases. Further research is required to fully elucidate the complex network of interactions and pathways involving USP60.。

ET63133YBQ2

ET63133YBQ2EtekMicroelectronics Ultra-Low I Q 150mA CMOS LDO RegulatorGeneral DescriptionThe ET63133YBQ2 CMOS are designed specifically for portable battery-powered applications which require ultra-low quiescent current as low dropout regulators. The ultra-low consumption of type 0.6uA ensures long battery life and dynamic transient boost feature improves device transient response for wireless communication applications.The device is available in small 1x1mm DFN4 packages.Features● Operating Input V oltage Range: 2.2V to 5.5V ● Ultra-Low Quiescent Current Typical 0.6uA● Low Dropout: 160mV Typ. at 150mA@VOUT=3.3V ● High Output V oltage Accuracy ±1%● Stable with Ceramic Capacitors 1uF ● Over-Current Protection● Thermal Shutdown Protection● Available in Small 1x1 mm DFN4 Packages● These Devices are Pb−F ree, Halogen Free/BFR Free and are RoHS CompliantApplications● Battery Powered Equipments● Portable Communication Equipments ● Cameras, Image Sensors and Camcorders ● Label InformationOutput Voltage ：3.3VET631 XX Y B Q2With auto discharge function at off state DFN4 PackagePIN1 DirectionPin ConfigurationPin FunctionBlock DiagramAbsolute Maximum Ratingsexceeded, device functionality should not be assumed, damage may occur and reliability may be affected.1. Refer to ELECTRICAL CHARACTERISTIS and APPLICATION INFORMATION for Safe Operating Area.2. This device series incorporates ESD protection and is tested by the following methods:ESD Human Body Model tested per EIA/JESD22-A114CDM tested per JESD22-C101Latch up Current Maximum Rating tested per JEDEC78Thermal CharacteristicsRecommended Operating ConditionsElectrical CharacteristicsVOLTAGE VERSION 3.3 VIN IN OUT,IN OUT is safety.4. V DROP FT test method: Test the Vout voltage at Vset+V DROPMAX with 150mA output current.5. Guaranteed by design and characterization. Not a FT item.6. The minimum operating voltage is 2.2V.V DROP=V IN(min)-V OUT。

b33二极管

Package Dimensions in mm (inches)
Mechanical Data
Case: MicroMELF Weight: approx. 12 mg
Maximum Ratings and Thermal Characteristics
(Tamb=25oC, unless otherwise specified)
Parameter
Symbol
Value
Unit
Zener current (see Table "Characteristics")
Power dissipation at RthJA < 300K/W Junction temperature
Storage temperature range
Forward voltage at IF=200mA Junction ambient (mounted on epoxy-glass hard tissue, Fig.1) Junction ambient (35um copper clad, 0.9mm2 copper area per electrode))
Min.
2.28 2.50 2.80 3.10 3.40 3.70 4.00 4.40 4.80 5.20 5.80 6.40 7.00 7.70 8.50 9.40 10.40 11.40 12.40 13.80 15.30 16.80 18.80 20.80 22.80 25.10 28.00 31.00 34.00 37.00 40.00 44.00 48.00 52.00 58.00 64.00 70.00
VZ @ IZT (V)
Dynamic resistance

Deep UV nonlinear optical crystal_RbBe(BO3)F2

Deep UV nonlinear optical crystal:RbBe2…BO3…F2Chuangtian Chen,1,*Siyang Luo,1,2Xiaoyang Wang,1Guiling Wang,1Xiaohong Wen,1Huaxing Wu,1,2Xin Zhang,1,2and Zuyan Xu11Key Laboratory of Functional Crystals and Laser Technology,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing100190,China2Graduate University of the Chinese Academy of Sciences,Beijing100190,China*Corresponding author:cct@Received March26,2009;accepted May27,2009;posted March6,2009(Doc.ID108906);published July8,2009Sizeable crystals of RbBe2͑BO3͒F2(RBBF)were obtained by theﬂux method.The crystal structure was deter-mined by x-ray data and the space group was proven to be R32,belonging to the uniaxial class.The linear andnonlinear optical parameters,including the cutoff wavelength,refractive indices,phase-matching angles,andeffective nonlinear optical coefﬁcients were determined for theﬁrst time to our knowledge,and then the Sell-meier equations were also constructed.By using an RBBF prism coupling device(PCD),tunable fourth-harmonic output from a Ti:sapphire laser and the sixth harmonic of an Nd-based laser were also obtained withrelatively high power.©2009Optical Society of AmericaOCIS codes:160.4330,190.4400.1.INTRODUCTIONWith developments in semiconductor photolithography,laser micromachining,material processing,as well assuper-high-resolution and angle-resolved photoemissionspectrometers,the need for coherent light wavelengthsbelow200nm has become increasingly urgent over thepast decade.Although excimer lasers can emit certain dis-crete coherent wavelengths in the UV and deep UV spec-tral regions with high average output power,scientists inthis area still need compact and efﬁcient solid-state lasersbecause of their narrow bandwidth,good beam quality,tunability,and relative ease of handling.It is obvious thatthe best way to produce deep UV coherent light withsolid-state lasers is through cascaded frequency conver-sion using deep UV nonlinear optical(NLO)crystals.Thus the key point in this important area is to discoversuitable high-performance NLO crystals.Up to now onlyKBe2BO3F2(KBBF)has been able to meet these demandsto a certain extent[1].However,it is well known that thiscrystal is very difﬁcult to grow because of its strong layertendency;thus,there is still ample scope for developingnew deep UV NLO crystals.Based on the anionic group theory of the NLO effect incrystals[2,3],we know that the NLO properties,birefrin-gence,and band gap in KBBF crystals are mainly deter-mined by the͑Be2BO3F2͒n→ϱlattice structure,while the K+cation has little effect on the above parameters.As aresult,it is conceivable that new deep UV NLO crystalscan be discovered through the substitution of Rb+and Cs+for K+,while the basic framework of the KBBF lattice willbe retained in the new crystals.With this approach andthrough systematical experimental investigations,twonew NLO crystals,RbBe2͑BO3͒F2(RBBF)and CsBe2͑BO3͒F2(CBBF),for deep UV harmonic generation have been discovered by our group[4,5].However,up to now only relatively large bulk crystals of RBBF have been successfully grown,so in this paper,only the basic struc-ture as well as the linear and nonlinear optical properties of the RBBF crystal will be discussed.Our results indi-cate that RBBF is an excellent deep UV NLO crystal. 2.EXPERIMENTALPolycrystalline RBBF was prepared by a normal solid-state reaction.The chemical equation is as follows: Rb2CO3+4BeO+2NH4H F2+2H3BO3=2Rb Be2BO3F2 +CO2↑+5H2O↑+2NH3↑.The starting compounds,all analytically pure,were mixed homogeneously in stoichiometric proportions, heated gradually up to700°C,and kept at that tempera-ture in air for2–3days.After cooling to room tempera-ture,the solid product was then ground to powder for the preparation of crystal growth.As an important addition, all of the operations had to be performed in a ventilated system to protect the operators because of the toxicity of BeO.A high-temperatureﬂux method was adopted to grow the single crystal in air using a spontaneous nucleation technique.Theﬂux and RBBF powder were mixed in the appropriate molar ratio and placed in a sealed platinum crucible to prevent the raw materials from volatilizing when heated in a furnace to850°C for2days to ensure complete dissolution of the solute.Afterwards,the tem-perature was lowered to the saturation temperature and kept constant forϳ20h to form the initial spontaneous nucleation seed crystals,then reduced at a rate of0.5ϳ2°C/day to maintain growth.After the required crystal size was reached,the temperature was reduced to room temperature within three days.The crystal was obtained after the residues in the crucible were dissolved by dilute acid.0740-3224/09/081519-7/$15.00©2009Optical Society of AmericaA Bruker P4single-crystal diffractometer with mono-chromatic Mo K ␣radiation ͑␭=0.71073Å͒was used to determine the structure of the RBBF crystal.The mea-surement was made at 20±1°C using a high-optical-quality RBBF crystal 0.1ϫ0.1ϫ0.2mm 3in size.The structure was then solved and reﬁned by using full-matrix least-squares reﬁnement on F 2with Shelxl-97software.The transmittance spectrum of the crystal on the UV side was performed on a spectrophotometer (VUVas2000,McPherson).The transmittance spectrum in the infrared was performed on a spectrophotometer (FTS-60V ,Bio-Rad).The refractive indices of the crystal were determined by the minimum deviation angle technique using an RBBF right-angle prism with a precision goniometer spectrom-eter (SGo1.1,Veb Freiberger Prazisionsmechanik).De-tails of the measurement of the refractive indices can be found in [6].The Maker fringes technique was used to determine the d 11coefﬁcient.A Q-switched Nd:YAG laser (Spectra-Physics,Model Pro 230)at 1064.2nm with a pulse width of 10ns and 10Hz repetition rate was used as the funda-mental light source.The second-harmonic signal from the sample crystals was selectively detected by a photomulti-plier tube (Hamamatsu,Model R105)and averaged by a fast-gated integrator and boxcar averager (Stanford Re-search Systems),then recorded.3.CRYSTAL GROWTH AND STRUCTUREIn 1975,Baydina [7]ﬁrst synthesized the compound,and then recently MCMillen et al.[8]succeeded in growing crystals of mm size using the hydrothermal method.How-ever,so far no optical properties of the crystal have been reported.Experimentally,RBBF crystals can now be grown by both ﬂux and hydrothermal methods.However,the ﬁrst sizeable crystal was grown in our group by the former method,which is convenient because the crystal decom-poses above 900°C before melting at about 1007°C.Fig-ure 1shows a picture of an as-grown RBBF single crystal of high quality that has a large transparent area greater than 40ϫ40mm 2and a thickness of 1.2mm.Its synthe-sis and growth are described in the experimental section.Baydina et al.[7]originally reported the structure of RBBF as being in the C2space group.After obtaining the single crystal we redetermined the structure on the basis of the x-ray data.Similar to KBBF [9],the space group of RBBF proved to be R32[point group D3(32)],belonging to the uniaxial class,with lattice constants a=b =4.4341͑9͒Åand c=19.758͑5͒Å(see Table 1).The space group has been further conﬁrmed by observations of the interference pattern,which shows explicitly uniaxial characteristics (Fig.2).The basic building units of RBBF are ͑BO 3͒3−and ͑BeO 3F ͒5−polyhedra.The B–O distances of the ͑BO 3͒3−Table 1.Crystallographic Data of RBBF aAtom Positional ParametersU ͑eq ͒b x y z Rb 0.00000.00000.00000.0285(17)F 0.00000.00000.72767(12)0.0282(5)O 0.3581(6)0.0248(6)0.83330.0208(5)B 0.66670.33330.83330.0172(8)Be0.00000.00000.8047(2)0.0189(7)aSpace group,R32͑trigonal system,D 3͒;cell parameters,a=b=4.4341͑9͒Å,c =19.758͑5͒Å,z=3;index ranges,−7Ͻh Ͻ7,−7Ͻk Ͻ7,−31Ͻl Ͻ31;range of ␪,3.09°Ͻ␪Ͻ34.99°;no.of observations of peaks with intensities I Ͼ2␴,323;R in-dices,R 1=0.0293,wR 2=0.0735;largest peak in ﬁnal difference map,1.598e.A −3.bU ͑eq ͒is deﬁned as one third of the trace of the orthogonalized U ijtensor.rge single crystal of RBBF with a transparent area greater than 40ϫ40mm 2.Fig.2.Interference pattern of RBBF along the caxis.Fig.3.(a)Crystal structure of RBBF.(b)Two-dimensional net-work structure of ͑Be 2BO 3F 2͒ϱ.groups in the structure are uniform and equal to 1.37Å,and the O–B–O bond angle is exactly 120°.The Be–O and Be–F bond lengths are 1.64and 1.52Å,respectively.The B and O atoms are located in the same plane perpendicu-lar to the c axis,while the Be atoms with Be–F bonds par-allel to the c axis are alternately above and below the plane at a distance of 0.566Å.Each ͑BO 3͒3−group joins two other adjacent ͑BeO 3F ͒5−groups in the same direc-tion to form an inﬁnite lattice sheet of ͑Be 2BO 3F 2͒ϱalong the a –b plane,which is the same as the framework of KBBF.The distance between neighboring layers is up to 6.59Å,but there are only weak Rb–F interactions to bind them.Therefore,the structure exhibits a layering ten-dency along the c axis,which makes it difﬁcult to grow thick crystals there.The structure of RBBF is depicted in Fig.3.The hardness of RBBF is 2.9on the standard Mohs hardness scale,which is much softer than BBO ͑ϳ4.0͒and LBO ͑ϳ6.0͒but harder than KBBF ͑ϳ2.6͒.The RBBF crystal is highly stable in air and even in hot water at 100°C or in acids such as HNO 3and HCl.4.LINEAR OPTICAL PROPERTIESAs shown in Fig.4,the cutoff wavelength of the crystal on the UV side is located at 160nm.The transmittance spec-trum in the infrared regions is shown in Fig.5,where we can see that the cutoff wavelength is 3550nm.By using a right-angle prism with an apex angle of 30.14°made from a 2.2mm thick RBBF crystal,nine re-fractive indices have been measured in the visible region.The data are listed in Table 2.However,these refractive indices are by no means enough to ﬁt the Sellmeier equa-tions of the crystal,because RBBF possesses a wide phase-matching wavelength range in the UV region.It is therefore necessary to use phase-matching angles,in the UV spectral region particularly,combined with refractive index data to ﬁt the Sellmeier equations.Table 3lists the type I phase-matching angles of the crystal in the wavelength range from deep UV to near in-frared.From these data,the Sellmeier equations can be obtained by ﬁtting the refractive indices and type I second-harmonic generation (SHG)phase-matching angles listed in Tables 2and 3,as follows:n o2=1+1.18675␭2␭2−0.00750−0.00910␭2n e 2=1+0.97530␭2␭2−0.00665−0.00145␭2͑␭is in ␮m ͒.͑1͒By using these Sellmeier equations,we can calculate the refractive indices of RBBF crystals within an accu-racy of four signiﬁcant ﬁgures.Figure 6and Table 2show the measured and calculated refractive indices.It can be seen that the theoretical values agree well with the ex-perimental data.The measured and calculated phase-matching angles are also shown in Fig.7and Table 3,Fig.4.Transmittance of RBBF crystal in the UVregion.Fig.5.Transmittance of RBBF crystal in the IR region.Table 2.Measured and Calculated Refractive Indices of RBBF with ⌬as the Absolute Value of theDifference Between the Measured and Calculated ValuesWavelength(nm)n en o Cal Exp ⌬Cal Exp ⌬404.7 1.41998 1.419560.00042 1.49740 1.497610.00021435.8 1.41789 1.417480.00041 1.49459 1.494690.00010486.1 1.41535 1.415110.00024 1.49114 1.491280.00014491.6 1.41511 1.414930.00018 1.49083 1.490920.00010546.1 1.41319 1.413140.00005 1.48817 1.488270.00010577.0 1.41234 1.412380.00004 1.48697 1.487060.00009589.3 1.41203 1.411780.00025 1.48653 1.486360.00018656.3 1.41066 1.410710.00005 1.48454 1.484680.00014694.31.410051.410110.000061.483621.483840.00022Table3.Phase-matching Angles for Type I SHG with RBBF aFundamental Wavelength(nm)SHG Wavelength(nm)Phase-matching angle(deg)Exp Cal⌬354.7177.373.3873.070.31 360.0180.070.3170.50−0.19 365.0182.568.6468.400.24 370.0185.066.9266.540.38 375.0187.565.0464.850.19 380.0190.063.5163.300.21 385.0192.561.8561.87−0.02 390.0195.060.6060.530.07 395.0197.559.4959.280.21 400.0200.058.0458.11−0.07 405.0202.556.9457.00−0.06 410.0205.055.8355.95−0.12 415.0207.554.8854.96−0.08 420.0210.054.1454.010.13 425.0212.553.3953.100.29 430.0215.052.3752.240.13 435.0217.551.5851.410.17 440.0220.050.8150.610.20 515.0257.541.1741.52−0.35 529.6264.839.8640.18−0.32 532.0266.039.9739.970 549.7274.938.2438.51−0.27 570.2285.136.7436.96−0.22 589.7294.935.3835.62−0.24 610.0305.034.0034.35−0.35 629.7314.932.8933.22−0.33 664.5332.331.3831.44−0.06 730.0365.028.5528.68−0.13 740.0370.028.2028.32−0.12 750.0375.027.8227.97−0.15 750.1375.127.8327.97−0.14 760.0380.027.5527.63−0.08 760.8380.427.5627.60−0.04 770.0385.027.1627.30−0.14 780.0390.026.9326.99−0.06 790.0395.026.5526.69−0.14 799.7399.926.3026.40−0.10 800.0400.026.2626.39−0.13 810.0405.026.0426.11−0.07 812.2406.126.1226.050.07 820.0410.025.8125.84−0.03 830.0415.025.5225.58−0.06 840.0420.025.2825.32−0.04 849.4424.725.0525.09−0.04 850.0425.025.0525.08−0.03 860.0430.024.8024.84−0.04 870.0435.024.6624.620.04 880.0440.024.3624.40−0.04 897.7448.923.9324.03−0.10 949.8474.923.2223.070.15 997.7498.922.5322.340.19 1064.0532.021.6221.530.09 1109.0554.521.4221.100.32 1203.1601.620.9020.460.44 1299.2649.620.4420.120.32 1399.5699.820.3420.020.32a Exp,measured angles;Cal,angle calculated using the Sellmeier equations;⌬,difference between the measured and calculated values.which indicate that it is possible to achieve SHG phase-matching down to 170nm.Thus RBBF has a wide phase-matching range,particularly in the deep UV range.5.NONLINEAR OPTICAL PROPERTIESSimilar to KBBF in the space group R32,RBBF also has only two nonzero d ij coefﬁcients,i.e.,d 11and d 14.The ma-trix form of the coefﬁcients can be written as follows:΂d 11−d 110d 14000000−d 14−d 11΃.͑2͒Theoretical and experiment calculation both reveal that d 14is very small.On the other hand,the effective d eff coefﬁcients of RBBF are as follows:d 11cos ␪cos 3␾͑type-I ͒,d 11cos 2␪sin 3␾͑type-II ͒.͑3͒We can see that the d 14coefﬁcient does not contribute to the d eff coefﬁcients;thus,it is only d 11that needs to be determined.This has been precisely measured by the Maker fringes technique with a 10ϫ10ϫ1.0mm 3c -cut crystal plate (the arrangement of the axes is shown in Fig.8).Figure 9shows the Maker fringes,where the dashed curves represent the theoretical fringes and enve-lope based on the refractive indices calculated from the Sellmeier equations [Eq.(1)].Figure 9shows clearly that the theoretical Maker fringes coincide with the experi-mental curve very well.Through comparison between the fringe envelope of the d 11coefﬁcient of RBBF and that for the d 36coefﬁcient of KDP as a reference,for the former we can deduce exactly that d 11=͑0.45±0.01͒pm/V (if d 36͑KDP ͒=0.39pm/V is adopted),which is comparable to that of KBBF [10].As with KBBF [11],the as-grown RBBF is still too thin to be cut along the phase-matching direction for produc-ing deep UV harmonic generation below 200nm.To solve this problem,we also adopt the special prism coupling de-vice RBBF-PCD [12].Figure 10shows this sandwich structure in which the interfaces between the fusedsilicaFig.7.Type I SHG phase-matching angles versus fundamental wavelength for RBBF in the whole spectral region.Solid line,curve calculated from the Sellmeier equations;circles,data from theexperiments.Fig.8.Arrangement of the sample axes for the determination of the d 11coefﬁcient ofRBBF.Fig.9.Maker fringes of the d 11coefﬁcient of RBBF.Solid curve,experimental Maker fringe (type-I)of d 11;dashed curves,theo-retical fringe and theoreticalenvelope.Fig.6.Dispersion of refractive indices.The triangles are experi-mental data.The curves are calculated from the Sellmeier equa-tions (1).Fig.10.Schematic of the special prism coupling device withRBBF.(or calcium ﬂuoride crystal)and RBBF are totally opti-cally ing this RBBF-PCD device,tunable fourth-harmonic generation of Ti:sapphire lasers has been successfully realized.In the experiment,a femtosec-ond Ti:sapphire laser (Chameleon-ultra II,Physical-spectral,150fs,80MHz)is used for the fundamental wavelengths.One BBO crystal produces the SHG of the tunable fundamental wavelengths from 930to 720nm.Then,an RBBF-PCD with crystal dimensions of 20ϫ6ϫ0.95mm 3is used to produce fourth-harmonic genera-tion over the entire SHG wavelength range.Figure 11shows the tunable fourth-and second-harmonic power output curves as a function of fundamental wavelengths.Within the tunable deep UV range,the maximum power output is 44.1mW at 202.5nm when the relative SHG power at 405nm is 2.08W.From 185to 200nm,the power output can be maintained at over 12mW.There-fore,in addition to KBBF,RBBF is currently anotherNLO crystal that can produce deep UV harmonic genera-tion below 200nm through a simple SHG method.The sixth harmonic of an Nd-based laser can also be produced using an RBBF-PCD device.For example,with a nanosecond,10kHz,355nm laser,a maximum output power of 10.8mw at 177.3nm has been obtained recently using an RBBF-PCD device composed of fused silica and CaF 2prisms cut both at an angle of 75°and a crystal of dimensions 23ϫ6.0ϫ1.0mm 3.Figure 12shows the out-put power curves at 177.3nm as a function of the funda-mental wavelength power.6.CONCLUSIONIn this paper we report,to our knowledge,a novel deep UV NLO crystal RBBF,which can produce harmonic gen-eration below 200nm through a simple SHG method.Thermal analysis indicates that RBBF is an incongruent melting compound,so the crystal can be grown by the ﬂux method.Bulk crystal as large as 40ϫ40ϫ1.2mm 3(1.2mm along the c axis)can now be successfully grown.The x-ray data show that RBBF has the same space struc-ture as KBBF.The linear and nonlinear optical param-eters,including the cutoff wavelength,refractive indices,phase-matching angles,and the effective NLO coefﬁcients have been determined for the ﬁrst time to our knowledge,from which the Sellmeier equations have also been con-structed.By using an RBBF-PCD device,tunable fourth-harmonic output from a Ti:sapphire laser and the sixth harmonic of an Nd-based laser have also been obtained with relatively high power.These data show that RBBF is an excellent deep UV NLO crystal.Further efforts to grow larger bulk crystals and obtain even higher output powers are underway.ACKNOWLEDGMENTSThis work was supported by the State Key Program for Basic Research of China grant 2004CB619001and the National Natural Science Foundation of China (NSFC)grant 50772118.REFERENCES1.C.T.Chen,Z.Y.Xu,D.Q.Deng,J.Zhang,and G.K.L.Wong,“The vacuum ultraviolet phase-matching characteristics of nonlinear optical KBe 2BO 3F 2crystal,”Appl.Phys.Lett.68,2930–2932(1996).2. C.T.Chen,N.Y,J.Lin,J.Jiang,W.R.Zeng,and B.C.Wu,“Computer-assisted search for nonlinear optical crystals,”Adv.Mater.(Weinheim,Ger.)11,1071–1078(1999).3.Z.S.Lin,Z.Z.W,C.T.Chen,S.K.Chen,and M.H.Lee,“Mechanism for linear and nonlinear optical effects in KBe 2BO 3F 2crystal,”Chem.Phys.Lett.367,523–527(2003).4.X.H.Wen,Ph.D.Dissertation (Institute of Physics and Chemistry,Chinese Academy of Sciences,2006),China.5. C.T.Chen,X.H.Wen,R.K.Li,and C.Q.Zhang,China Patent CN 1904148A,2006.6.C.T.Chen,G.L.Wang,X.Y.Wang,Y.Zhu,Z.Y.Xu,T.Kanai,and S.Watanabe,“Improved Sellmeier equations and phase-matching characteristics in deep-ultraviolet region of KBe 2BO 3F 2crystal,”IEEE J.Quantum Electron.44,617–621(2008).7.I.A.Baydina,V .V .Bakakin,L.P .Bacanova,and N.A.Pal’chik,“X-ray structural study ofborato-ﬂuoroberyllatesFig.11.Tunable fourth-harmonic generation of a Ti:sapphire la-ser versus fundamental wavelength with an RBBF-PCD device.Squares,output power of SHG generated through BBO;dots,output power of fourth-harmonic generation produced byRBBF-PCD.Fig.12.177.3nm output power as a function of 355nm funda-mental power with an RBBF-PCD.with the composition MBe2͑BO3͒F2͑M=Na,K,Rb,Cs͒,”Zh.Strukt.Khim.16,963–965(1975).8. C. D.McMillen and J.W.Kolis,“Hydrothermal crystalgrowth of ABe2BO3F2͑A=K,Rb,Cs,Tl͒NLO crystals,”J.Cryst.Growth310,2033–2038(2008).9.L.Mei,X.Huang,Y.Wang,Q.Wu,B.Wu,and C.Chen,“Crystal structure of KBe2BO3F2,”Z.Kristallogr.210, 93–95(1995).10. C.T.Chen,“Recent advances in deep and vacuum-UVharmonic generation with KBBF crystal,”Opt.Mater.26, 425–429(2004).11. C.T.Chen and Z.Xu,“Prism coupling technique anddeep-UV harmonic output of KBBF crystal,”J.Synth.Cryst.31,224–227(2002).12. C.T.Chen,J.H.Lu,G.L.Wang,Z.Y.Xu,J.Y.Wang,C.Q.Zhang,and Y.G.Liu,“Deep ultraviolet harmonic generation with KBe2BO3F2,”Chin.Phys.Lett.18,1081 (2001).。

《基于Bi2MoO6和MoS2界面结构的构建及其污染物降解性能的研究》范文

《基于Bi2MoO6和MoS2界面结构的构建及其污染物降解性能的研究》篇一一、引言随着环境污染的日益严重，研究有效的污水处理方法及材料对于环保和生态建设具有重要价值。

其中，光催化技术以其绿色、高效、环保的特性受到了广泛关注。

本文着重研究了一种基于Bi2MoO6和MoS2界面结构的构建及其在污染物降解方面的性能。

二、Bi2MoO6和MoS2的基本性质与特点1. Bi2MoO6Bi2MoO6是一种典型的铋基半导体材料，具有良好的化学稳定性、无毒性以及较高的光催化活性。

其独特的层状结构使得光生电子和空穴有较长的寿命，有利于光催化反应的进行。

2. MoS2MoS2是一种典型的二维过渡金属硫化物，具有较高的电子迁移率和较大的比表面积，是光催化领域的优秀材料。

此外，MoS2还具有良好的耐腐蚀性和较高的稳定性。

三、Bi2MoO6和MoS2界面结构的构建本研究通过特定的合成方法，成功构建了Bi2MoO6和MoS2的界面结构。

这种结构能够有效地提高两种材料的光催化性能，因为它们之间能够形成异质结，加速光生电子和空穴的分离和传输，从而提高光催化反应的效率。

四、污染物降解性能研究本研究选择了几种典型的有机污染物（如罗丹明B、甲基橙等）进行降解实验。

实验结果表明，基于Bi2MoO6和MoS2的界面结构在可见光照射下对上述污染物具有良好的降解效果。

其降解效率远高于单一材料，这得益于异质结的形成和光生电子的快速转移。

此外，该材料还具有较好的稳定性和可重复使用性。

五、结果与讨论通过实验数据，我们可以得出以下结论：1. Bi2MoO6和MoS2的界面结构可以有效地提高光催化降解污染物的性能。

2. 该界面结构在可见光照射下对多种有机污染物具有优异的降解效果。

3. 异质结的形成和光生电子的快速转移是提高光催化性能的关键因素。

4. 该材料具有良好的稳定性和可重复使用性，为实际应用提供了可能。

六、结论与展望本研究成功构建了基于Bi2MoO6和MoS2的界面结构，并对其在光催化降解污染物方面的性能进行了研究。

一种检测抗苗勒管激素含量的酶联免疫试剂盒及其检测方法[发明专利]

专利名称：一种检测抗苗勒管激素含量的酶联免疫试剂盒及其检测方法
专利类型：发明专利
发明人：邓陈玲,华权高
申请号：CN201911313451.X
申请日：20191219
公开号：CN110940817A
公开日：
20200331
专利内容由知识产权出版社提供
摘要：本发明提供一种检测抗苗勒管激素含量的双抗夹心酶联免疫试剂盒及其检测方法，所述试剂盒包括由捕获抗体包被的酶标板、样本稀释液、标准品、生物素标记的检测抗体、辣根过氧化物酶标记的亲和素、浓缩洗涤液、底物溶液和终止液；其中，所述捕获抗体为鼠抗人AMH抗体；所述样本稀释液为1×PBS+1％BSA+0.05％Tween‑20+0.1％Proclin300；所述标准品为人AMH冻干标准品；所述检测抗体为抗人AMH抗体；所述浓缩洗涤液为含有
25×PBS+1.25％Tween20+2.5％Proclin300的25×PBST，其pH为7.6；所述底物溶液为TMB显色底物溶液；所述终止液为2M硫酸。

本发明所述试剂盒及其检测方法减少了人力及设备成本，减少了原料、样本使用量以及降低了成本，从而提高了使用效率。

申请人：武汉华美生物工程有限公司
地址：430206 湖北省武汉市东湖开发区高新大道818号高科医疗器械园B11栋
国籍：CN
代理机构：北京众达德权知识产权代理有限公司
代理人：刘杰
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U nit 2 Healthy Eating Using language 2 (Period 6)班级：姓名：小组：评价：Learninging goals:To learn about the importance of balanced dietKey point and difficult points: Master important phrases.Learning skills：self-study and group workStep One :Leading-in(3mins)Step Two:Thinking((≥13mins)1. Yong Hui agreed to stay and soon---1) agree with sb./with one’s words /opinion2) agree to sth( plan,suggestion,arrangement等名词)3) agree to do sth. 但不说agree sb. to do sth.4) agree 后面接从句5) agree on达成协议练一练：I agree their suggestionI agree what you said.The two sides agreed the date of the meeting.feel sick难受，想呕吐She feels sick when she eats fat. 她吃肥肉时想吐。

3.Wang Peng was just enjoying a second plate of dumplings...王鹏正要吃另一盘饺子……序数词与the 连用表示“第几” .强调排列的顺序。

序数词与 a 连用表示“又一，再一”You are the second to tell me the news.你是第二个告诉我这个消息的。

The boss asked a third one whose turn it would be to be on duty tonight.老板又问了一个人今天晚上谁值班。

4. I do have to rest a lot.我确实需要多休息。

do在这里起强调谓语动词的作用。

We did go to meet him yesterday，but he had gone when we got there.我们昨天确实去接他了，但是我们到那里的时候他已经走了。

Jack does like pets，so he raises many little animals.杰克太喜欢宠物了，所以他养了好多小动物。

5.But don’t you think it would be better if you were a bit thinner?可是你不认为如果你再瘦一点的话会更好吗？a bit表示“一点儿，一些”，此处用来修饰比较级(=a little）e.g.After he did much practice，his spoken English is a bit better.在做了大量练习之后，他的口语好多了。

拓展：a bit和a little都作"一点儿"讲,但用法不同。

1)a bit和a little在肯定句中修饰动词、形容词、副词和比较级时可以互换,表示"一点儿"的意思。

e.g.He felt a bit/a little hungry. 他觉得有点儿饿。

2)a bit和a little在否定句中的意思恰恰相反,not a bit相当于"not at all"(一点儿都不);not a little相当于"very(much)"或"extremely"(很、非常)。

He is not a bit like his brother. （= He is not like his brother at all. ）他一点儿也不像他He is not a little like his brother. （= He is extremely like his brother.）他很像他的兄弟。

3)a little可以直接作定语修饰名词,而a bit则要在后面加of构成短语才能作定语,两者都只能修饰不可数名词。

He has a bit of/a little money left. 他剩下的钱很少。

6. According to my research, neither your restaurant nor mine offers a balanced diet," explained Wang Peng. "王鹏解释道，“我的研究表明，你我两家饭店所提供的都不是平衡膳食。

（1)neither...nor... 既不……也不……。

用来连接句子的并列成分。

e.g.Neither Xiaoli nor his brothers like to stay at home at weekend.小李和他哥哥在周末都不愿意呆在家里。

My father likes neither majiang nor smoking. 我父亲既不喜欢打麻将也不喜欢吸烟。

Neither our teacher nor we students like the food in the school dinning room.老师和学生都不喜欢学校食堂的饭菜。

(2)offer v. 提供；供给。

①动词句型: offer sth (主动)给某物offer sb sth =offer sth to sb (主动)给某人某物offer to do sth (主动)提出/愿意做某事offer sth for (money) 以多少钱出售某物offer sb (money) for sth / to buy sth 出价多少购买某物②名词句型make an offer to do 主动提出做…..make an offer of…… 主动提出…..accept an offer to do（of）…接受……的建议e.g. The young man offered the old man his own seat on the bus.那个年轻人在公共汽车上将自己的座位让给了那个老人。

He offered to lend me some books. 他要借给我几本书。

We offered him 10,000 yuan for his house.我们愿出一万元钱来购买他的房子。

He offered this bike for 600 yuan. 这辆自行车他要价600元。

7. Perhaps we ought to combine our ideas and provide a balanced menu with food full of energy and fibre. "也许我们应该把我们的想法综合起来，作出一份富于营养、热量和纤维的平衡食谱。

”combine vt.&vi. (使)联合；（使）结合combine A and B / combine A with B把A和B结合起来常用结构:combine into ... 联合成……combine ...with ...把……与……结合起来We consider it is necessary to combine theory with practice. 我们认为理论联系实际是必要的。

Hydrogen combines with oxygen to form water. 氢与氧化合生成水。

易混辨析:join/combine/unite/connect1)combine 意为“结合、联合”，指为了某一目的而把两事物结合在一起。

The new teaching method combines education with pleasure. 新的教学方法寓教于乐。

2)connect“连接”，指用东西把两事物连接在一起，或两事物直接相连，二者仍保持原状。

(connect…with/to…)The two cities are connected by a railway. 两座城市由铁路相连。

He connected the gas stove with gas pipe.他把煤气和接在煤气炉上。

3)join 意为“连接”，指以线、绳、桥等把两物或两地连接在一起，和connect意思相近，也可指两物互相紧密相接。

(join…to.. 把……与……连接起来)We had better join the island to the mainland with a steel bridge.我们最好建一座钢筋桥把这个岛与大陆连接起来。

4)unite 意为“联合;团结”，指两种以上的事物结合为一体，有合二为一的意味，强调结合后的统一性。

The two companies will unite into one.这两家公司将合并成一家。

The whole family united to help him.全家齐心协力帮助他。

高手过招单项填空1.The two parties have to form a new government.A. mixedB. combinedC. joinedD. formed2. Chinese traditional medicine with western medicine.A.LinkB. ConnectC. CombineD. Join3..Please ____ me to London.A.joinB.unitbineD.connect4. If your knowledge can be in some way _______ with my experiences, we are sure to succeed.A. joinedB. unitedC. connectedD. combined5. ,we stand,divided(分裂)，we fail.A.UniteB.UnitingC.UnitedD.To unite8. In this way they cut down the fat and increased the fibre in the meal.这样，他们减少了饭菜中的脂肪含量，增加了纤维素。

cut down削减；删节；砍伐cut off 剪下来；切断；使突然中断cut out 切去；省略；停止（做某事）cut up=cut into pieces 切碎；剪碎cut through 穿过；穿透cut in 插入；插嘴；超车抢道高手过招用cut相关短语的适当形式填空①Her little finger was in an accident at the factory.②She the advertisement of the newspaper.③He the park and reached there in time.④I haven’t given up drinking but I’m .⑤I’m sorry to on your conversation.⑥You nearly caused a crash （撞车）by (on me) like that. 练一练：完成句子1.He said this is （第三次）that he had failed, but he would go on trying until he succeeded.2. It is such a wonderful play that I want to see it . 这么好的一部戏，我想再看一次。