Pancuronium_dibromide_SDS_MedChemExpress
莫博赛替尼化学结构

莫博赛替尼化学结构全文共四篇示例,供读者参考第一篇示例:莫博赛替尼(Imatinib,商品名格列卫)是一种靶向治疗白血病的药物,也被用于治疗一些其他类型的癌症。
它是通过靶向特定的蛋白质,从而阻断癌细胞的生长和扩散。
莫博赛替尼的化学结构是一种非常复杂的有机分子,其分子式为C29H31N7O,分子量为493.604克/摩尔。
莫博赛替尼的化学结构包含一个核心环结构,由苯环和嘧啶环连接而成。
苯环是由六个碳原子和六个氢原子组成的环状结构,而嘧啶环是由一个氮原子和四个碳原子组成的环状结构。
这两个环通过一个氮原子相连,形成了一种特殊的结构,这种结构对于莫博赛替尼的药效非常重要。
莫博赛替尼在体内主要靶向作用于一种叫做BCR-ABL融合蛋白的蛋白质。
这种融合蛋白质是一种异常的蛋白质,由Bcr(一种信号传导蛋白)和Abl(一种酪氨酸激酶)两种蛋白质的部分结构融合而成。
这种异常蛋白质的产生是由于某些白血病细胞的染色体发生了特定的基因突变,导致Bcr和Abl两种基因相互融合。
而莫博赛替尼正是针对这种异常的蛋白质进行靶向治疗的。
莫博赛替尼的化学结构设计和药效机制是经过长期的研究和开发的。
科学家们通过不断的实验和研究,逐渐了解了白血病细胞的基因突变以及融合蛋白质的结构和功能特点。
通过对这些信息的深入研究,他们最终设计出了莫博赛替尼这种能够精准干预癌细胞生长的药物。
莫博赛替尼在临床应用中被证实具有显著的疗效,尤其是对于慢性髓细胞白血病(CML)和胃肠间质瘤(GIST)等罕见白血病和恶性肿瘤的治疗效果非常显著。
通过连续服用莫博赛替尼,患者的白血细胞数量可以得到控制,进而延缓疾病的进展并提高生存率。
莫博赛替尼的治疗效果和安全性已经得到了许多临床试验和长期随访的验证,被广泛应用于临床治疗。
莫博赛替尼是一种非常重要的抗癌药物,通过靶向作用于异常蛋白质来抑制癌细胞的生长和扩散。
其化学结构复杂且精确,对于白血病和其他类型的癌症具有显著的治疗效果。
西布曲明分子成份

西布曲明分子成份西布曲明(Sibutramine)是一种曾经广泛应用于减肥药物的成分,它的分子结构独特,具有显著的减重效果。
然而,随着对其副作用的深入了解,西布曲明在许多国家的使用受到了严格限制,甚至被部分国家禁止使用。
本文将对西布曲明的分子成份、药理作用、应用领域、副作用与禁忌进行全面解析,以期帮助读者更好地了解这一药物成分。
一、西布曲明简介西布曲明是一种中枢神经系统作用药物,最早由德国制药公司研发,于1997年在美国上市,随后在许多国家投入使用。
它的主要作用是通过抑制神经递质再摄取,从而增加饱腹感、降低食欲,达到减轻体重的目的。
二、西布曲明的分子结构西布曲明的分子式为C17H26N2O,分子量为284.38。
它的分子结构包含一个苯环、一个异恶唑环和一个氮原子,呈现出独特的三角形状。
这种结构使西布曲明具有较高的脂溶性和中枢神经系统渗透性,有利于其在体内的吸收和作用。
三、西布曲明的药理作用西布曲明的药理作用主要通过作用于中枢神经系统内的神经递质受体来实现。
它可抑制5-羟色胺(5-HT)、去甲肾上腺素(NE)和多巴胺(DA)的再摄取,从而增加神经递质在突触间隙的浓度,产生饱腹感、降低食欲、提高能量消耗等效果。
这些作用使得西布曲明在减肥领域具有一定的疗效。
四、西布布曲明的应用领域西布曲明主要用于治疗肥胖症和体重过度增加的患者。
根据临床研究,使用西布曲明进行减肥治疗的患者,在一年内可减轻约5%-10%的体重。
然而,由于西布曲明的副作用和禁忌较多,如今在许多国家的使用受到了限制。
五、西布曲明的副作用与禁忌西布曲明的常见副作用包括头痛、失眠、恶心、呕吐、心率增快等。
此外,它还可能引发严重的副作用,如高血压、心肌梗塞、中风等。
因此,西布曲明仅适用于肥胖症患者,不适用于高血压、心脏病患者及孕妇等特殊人群。
在使用西布曲明进行减肥治疗时,患者需遵医嘱,并定期进行检查以确保安全。
六、总结西布曲明作为一种曾经广泛应用于减肥领域的药物成分,其独特的分子结构和药理作用使其具有一定的减重效果。
biontech lpx成分

Biontech LPX 成分Biontech LPX 是一种新型的基因疗法药物,它的主要成分是一种特殊的脂质纳米颗粒。
这种脂质纳米颗粒是由多种生物大分子组成,包括磷脂、胆固醇和 PEG 脂质。
这些成分在制备 Biontech LPX 时起到了非常重要的作用,它们为药物提供了良好的稳定性和生物相容性,使得 Biontech LPX 能够有效地传递基因药物到靶细胞内。
1. 磷脂磷脂是构成细胞膜的主要成分,它具有双亲性的化学性质,既能够与水相互作用,又能够与脂肪相互作用。
在 Biontech LPX 中,磷脂主要起到了包裹和保护 mRNA 分子的作用。
由于 mRNA 分子本身非常容易被降解,所以需要通过包裹在磷脂纳米颗粒内来提高其稳定性和细胞摄取率。
2. 胆固醇胆固醇是一种重要的生物大分子,在细胞膜的结构和功能上发挥着非常重要的作用。
在 Biontech LPX 中,胆固醇的加入可以增加纳米颗粒的稳定性和生物相容性,使得纳米颗粒能够更好地在体内循环并传递基因药物到靶细胞内。
3. PEG 脂质PEG 脂质是一种水溶性的聚合物,它具有良好的生物相容性和生物降解性。
在 Biontech LPX 中,PEG 脂质的加入可以增加纳米颗粒在体内的循环时间,并减少免疫反应的发生,从而提高基因药物的传递效率和安全性。
总结Biontech LPX 是一种基因疗法药物,其主要成分是一种特殊的脂质纳米颗粒。
这种纳米颗粒由磷脂、胆固醇和 PEG 脂质组成,它们能够为基因药物的传递提供良好的稳定性和生物相容性。
通过了解 Biontech LPX 的成分和作用机制,我们可以更好地理解其在基因治疗领域的应用前景和潜在的临床效果。
Biontech LPX 成分对于药物的效果有着重要影响,值得相关研究者和医学工作者进一步深入研究和探讨。
Biontech LPX 的发展和应用将为基因疗法领域的发展带来新的希望和机遇。
Biontech LPX 成分的研究和开发将有助于推动基因疗法领域的进步,为更多患者带来健康和幸福。
维莫非尼片说明书

核准日期:2017年3月10日修改日期:2017年5月26日2017年11月29日2018年7月24日2020年2月13日2021年2月26日2022年1月17日2022年2月22日维莫非尼片说明书请仔细阅读说明书并在医师指导下使用【药品名称】通用名:维莫非尼片商品名:佐博伏®,英文商品名Zelboraf®英文名:Vemurafenib film-coated tablets汉语拼音:Weimofeini Pian【成份】本品主要活性成分为维莫非尼,以维莫非尼和琥珀酸醋酸羟丙甲纤维素固体分散体存在。
化学名称:丙烷-1-磺酸{3-[5-(4-氯苯基)-1H- 吡咯并[2,3-b]吡啶-3-羰基]-2,4-二氟代苯基}- 酰胺。
化学结构式:分子式:C23H18ClF2N3O3S分子量:489.93【性状】两面凸起、粉白色至橙白色的薄膜衣片。
【适应症】佐博伏®适用于治疗经CFDA批准的检测方法确定的BRAF V600突变阳性的不可切除或转移性黑色素瘤。
【规格】240 mg【用法用量】患者必须经由CFDA批准的检测方法确定的证明肿瘤为BRAF V600突变阳性,才可使用佐博伏®治疗。
佐博伏®不能用于BRAF野生型黑色素瘤患者。
首剂药物应在上午服用,第二剂应在此后约12小时,即晚上服用。
每次服药均可随餐或空腹服用。
用一杯水送服药物,服药时整片吞下佐博伏®片剂。
不应咀嚼或碾碎佐博伏®片剂。
标准剂量佐博伏®的推荐剂量为960 mg(四片240 mg片剂),每日两次。
治疗持续时间建议佐博伏®治疗应持续至疾病进展或发生不可接受的毒性反应(参见表1和表2)。
漏服如果漏服一剂计划的药物,可在下一剂服药4小时以前补服漏服的药物,以维持每日两次的给药方案。
不应同时服用两剂药物。
呕吐如果佐博伏®服药后发生呕吐,患者不应追加剂量,而应按常规剂量继续治疗。
丁苯酞90天序贯治疗

康复期生活指导建议
合理饮食
指导患者保持低盐、低脂、高纤维的饮食习惯, 多摄入新鲜蔬菜和水果。
适当运动
根据患者的身体状况和兴趣爱好,为其制定个性 化的运动方案,如散步、太极拳等。
ABCD
规律作息
建议患者保持规律的作息时间,保证充足的睡眠 和休息。
情绪管理
教会患者一些简单的情绪管理技巧,如深呼吸、 冥想等,以缓解不良情绪。
经验教训分享
1 2
个体化治疗方案的重要性
在治疗过程中,应根据患者的具体情况制定个体 化的治疗方案,以提高治疗效果。
长期随访的必要性
为了评估丁苯酞序贯治疗的长期疗效和安全性, 需要对患者进行长期随访观察。
3
患者教育与心理支持的辅助作用
在治疗过程中,应加强对患者的教育和心理支持 ,帮助患者更好地应对疾病和治疗带来的压力。
血管性痴呆
辅助治疗血管性痴呆,提 高患者认知功能和生活质 量
其他神经系统疾病
还可用于其他神经系统疾 病如帕金森病、多发性硬 化等的辅助治疗
安全性与耐受性
安全性
丁苯酞在临床应用中安 全性较高,不良反应较
少
常见不良反应
少数患者可能出现轻度 胃肠道不适、头痛、头
晕等症状
禁忌症
对本品过敏者禁用,孕 妇及哺乳期妇女慎用
未来发展趋势预测
丁苯酞在治疗其他神经系统疾病中的应用
随着对丁苯酞研究的深入,未来可能会发现其在治疗其他神经系统疾病中的潜在应用价值 。
药物剂型的改进与优化
为了提高患者的用药体验和依从性,未来可能会对丁苯酞的剂型进行改进和优化。
联合用药方案的探索与实践
未来可能会探索丁苯酞与其他药物的联合用药方案,以期进一步提高治疗效果和降低不良 反应发生率。
兰德施泰纳

简介
姓名:兰德施泰纳 兰德施泰纳(1张) 籍贯:美籍奥地利裔职业:免疫学家 生卒:1868~1943 (Karl Landsteiner,1868.6.14~1943.6.26)
研究生涯
他最初研究化学,1892年与E.费施尔合成α-羟基乙醛。1896年后对血清学和免疫学产生兴趣,将化学方法 引入血清学研究,发现不同人的血清与血细胞混合后可发生凝集反应,1901年用抗A血清和抗B血清将血液分成A、 B、C(后称O)三型。1902年他的同事发现AB型。推断血型可以遗传。1904年他与J.多纳特提出诊断阵发性寒 冷性血红蛋白尿的试验,并阐述此病的发病机理。他又阐明胎粪性肠梗阻的病因。1905~1907年与合作者成功 地使猴感染梅毒,确定苍白密螺旋体存在于梅毒瘤中;创用螺旋体的暗视野显微镜观察法;阐明瓦瑟曼氏反应的 机制,并用牛心脏代替人体器官以提取抗原,使瓦氏试验得以广泛应用。1908~1919年用恒河猴等动物研究脊髓灰 质炎,设想其病原体为病毒,并与同事设计出一套血清诊断程序和保存病毒的方法。发现半抗原(1921),促进免疫 学的发展。他用化学和血清学技术区分出不同的血红蛋白;与合作者发现凝集素α1和α2(1926),MN等血液因子 (1927)、一种仅存在于黑人血液中的因子(今称亨特-享肖二氏系统)(1934)及Rh因子(1940)等;1930~1932 年与合作者成功地培养出流行性斑疹伤寒的病原体普氏立克次氏体。1936年发表免疫学经典著作《血清学反应的 特异性》。
兰德施泰纳
美籍奥地利裔免疫学家01 简介源自目录02 研究生涯
美籍奥地利裔免疫学家。1868年6月14日生于维也纳的巴登,1943年6月26日卒于纽约。因发现人的主要血 型系统而获1930年诺贝尔生理学或医学奖。1891年获维也纳大学医学院医学博士学位。1892~1894年间在德国 和 瑞 士 研 究 化 学 。 1 8 9 6 ~ 1 9 0 8 年 先 后 在 维 也 纳 大 学 卫 生 系 和 病 理 解 剖 研 究 所 任 职 。 1 9 11 年 任 病 理 学 教 授 。 1 9 2 2 年应邀赴美国纽约洛克菲勒研究所工作,1929年入美国籍。
恩必普发展历程

“抗惊药物”
• 70年代末,丁苯酞被证明有明显抗惊及中 枢镇静作用。 • 80年代,经研究丁苯酞具有广谱抗惊作用。 能增强大鼠学习记忆,促进和改善小鼠学 习记忆的获得和巩固的作用。 • 由于丁苯酞抗惊作用的剂量与毒性剂量接 近,因而没有被继续开发。
二次研究
• 90年代 冯亦璞等药学专家对丁苯酞的生理功能进行 了更深入的研究。 • 经多种模型筛选发现其具有明显的脑缺血 损伤保护作用,且毒副作用小。
谁最先发现丁苯酞
• 在pubmed上检索到最早报道丁苯酞 (butylphthalide)的文献为日本人,时间为 1966年
丁苯酞在中国
• 七十年代中国医学科学院药物研究所科研 人员开始了对芹菜有效成分的系统研究。 • 1978年杨峻山教授从芹菜籽挥发油中分离 出芹菜甲素 • 1980年杨靖华合成了消旋正丁基苯酞(DLbutylphthalide,NBP)
• 研究丁苯酞在 研究丁苯酞在SHR的降血压和扩血管的机制,实验提示丁苯酞的扩血 的降血压和扩血管的机制, 的降血压和扩血管的机制 管的作用可归因于阻滞钙通道,很可能是电压和受体依从性钙通道, 管的作用可归因于阻滞钙通道,很可能是电压和受体依从性钙通道, 因而能降低SR的收缩压 的收缩压。 因而能降低SR的收缩压。
学术定位
• 石药集团对恩必普的学术定位:
“重构微循环,保护线粒体”
• 恩必普的作用机制基本是建立在冯亦璞等 在研究丁苯酞时所得的实验结果。
对脑细胞的影响
• 能降低脑缺血侧皮层Calcineurin 和Calpain 的活性,从 而阻止神经细胞凋亡的启动; • 抑制低糖低氧刺激后神经细胞谷氨酸和5-羟色胺释 放,这是抗脑缺血作用的机制之一; • 抑制低糖低氧条件下神经细胞内钙升高,作用环节 主要是抑制细胞内钙库的释放而造成的脑细胞损伤 ,发挥良好的脑保护作用; • 对抗氯化钾及NMDA 诱导的神经细胞损伤; • 对低糖低氧引起的细胞损伤也有很好的保互作用; • 明显改善大鼠缺血脑线粒体呼吸链的功能。
Pimecrolimus_SDS_MedChemExpress

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :PimecrolimusCatalog No. :HY-13723CAS No. :137071-32-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4),H302Acute aquatic toxicity (Category 1),H400Chronic aquatic toxicity (Category 1),H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effects.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents/ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:SDZ⁻ASM 981Formula:C43H68ClNO11Molecular Weight:810.45CAS No. :137071-32-04. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077Class: 9Packing group: IIIEMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutant.IATAUN number: 3077Class: 9Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
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Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Pancuronium (dibromide)Catalog No. :HY-B0429CAS No. :15500-66-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4),H302Acute aquatic toxicity (Category 1),H400Chronic aquatic toxicity (Category 1),H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effects.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents/ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:C35H60Br2N2O4Molecular Weight:732.67CAS No. :15500-66-04. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance Off-white to pink (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077Class: 9Packing group: IIIEMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutant.IATAUN number: 3077Class: 9Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。