LY2835219_1231930-82-7_CoA_MedChemExpress
气相色谱法测定盐酸氨溴索口服液中丙二醇和甘油的含量
气相色谱法测定盐酸氨溴索口服液中丙二醇和甘油的含量发布时间：2021-12-30T08:42:30.803Z 来源：《中国科技人才》2021年第25期作者：韩婷婷[导读] 盐酸氨溴索，其化学名称为反式4一[(2一氨基?3，5.二溴.苄基)氨基]环己醇盐酸盐，是一种祛痰药。
哈药集团三精制药有限公司黑龙江省哈尔滨市 150069摘要：基于气相色谱法测定盐酸氨溴索口服液中丙二醇和甘油的分析方法，采用HP-INNOWAX色谱柱进行分离，外标法定量。
实验结果表明，丙二醇在50.4～806.0μg/mL范围内线性关系良好，相关系数为0.9995，平均回收率为99.1%，RSD=1.01%；甘油在190.5～3048μg/mL范围内线性关系良好，相关系数为0.9995，平均回收率为99.8%，RSD=0.97%；二者的方法检出限：丙二醇为0.10g/100g，甘油为0.10g/100g，方法检出限低，重复性好，结果准确可靠，适用于盐酸氨溴索口服液中丙二醇和甘油含量的测定。
关键词：气相色谱法；盐酸氨溴索；口服液；丙二醇；甘油盐酸氨溴索，其化学名称为反式4一[(2一氨基?3，5.二溴.苄基)氨基]环己醇盐酸盐，是一种祛痰药。
由于其生产过程带人乙酸、甲醇、乙醇、丙酮、甲苯等有机溶剂，因此有必要建立控制这几种有机溶剂残留量的测定方法。
盐酸氨溴索(ambroxolhydrochloride)系一种祛痰药，具有粘液溶解作用，能增加呼吸道黏膜浆液腺的分泌，减少粘液腺分泌，从而降低痰液粘度;还可促进肺表面活性物质的分泌，增加支气管纤毛运动，使痰液易于咳出。
同时，它还具有祛痰、增强肺表面活性物质的合成和分泌以及抗急性肺损伤的药理作用，在临床上广泛应用于小儿支气管肺炎、新生儿肺炎及胎粪吸入性肺炎等呼吸系统疾病的辅助治疗，倍受国内儿科医师的青睐。
盐酸氨溴索口服液的主药为盐酸氨溴索，辅料有山梨醇、丙二醇、甘油、酒石酸、糖浆、纯水等。
Bedaquiline fumarate_845533-86-0_DataSheet_MedChemExpress
Product Name:Bedaquiline fumarate CAS No.:845533-86-0Cat. No.:HY-14881A Product Data SheetMWt:671.58Formula:C36H35BrN2O6Purity :>98%Solubility:DMSOMechanisms:Biological Activity:Bedaquiline fumarate(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the Pathways:Anti-infection; Target:Antibacterial q (;)g y mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states ofMycobacterium tuberculosis.IC50 value:Target: anti-TB Preclinical studies have shown the efficacy of bedaquiline in terms of reduction in bacterial load and treatment duration. Phase II clinical studies have established the safety, tolerability and earliersputum conversion time in patients with MDR-TB. In 2012 FDA approved bedaquiline for treatment of MDR-TB and XDR-TB [1]. Bedaquiline possesses a unique mechanism of action that disrupts the ti it f th b t i l d i t i h h t th Cli i l t i l h b d t d References:[1]. Lakshmanan M, et al. Bedaquiline - The first ATP synthase inhibitor against multi drug resistanttuberculosis. J Young Pharm. 2013 Dec;5(4):112-115.[2]Chahine EB et al Bedaquiline:a novel diarylquinoline for multidrug-resistant tuberculosis Ann activity of the mycobacterial adenosine triphosphate synthase. Clinical trials have been conducted evaluating the use of bedaquiline in combination with a background regimen for the treatment of adults with pulmonary MDR-TB. Bedaquilin...[2]. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. AnnPharmacother. 2014 Jan;48(1):107-15.Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AT E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。
人参皂苷治疗骨性关节炎的研究进展
特产研究163Special Wild Economic Animal and Plant ResearchDOI：10.16720/ki.tcyj.2023.093人参皂苷治疗骨性关节炎的研究进展郭校妍1，张伟东1，张扬1※（吉林大学药学院，吉林长春130021）摘要：人参在防治关节软骨损伤退变及参与体外培养软骨细胞修复关节软骨缺损中具有较好治疗前景。
人参皂苷作为人参的主要药理活性成分，在治疗骨性关节炎的进程中发挥关键作用。
人参皂苷根据不同的结构被分为不同的类型，各类型均含有多种人参皂苷单体成分，其治疗骨性关节炎的机制也各不相同。
本文对不同人参皂苷单体治疗骨性关节炎的研究进行梳理和总结，探讨其治疗骨性关节炎的潜在可能性和作用机制，为后期临床应用提供依据。
关键词：骨性关节炎；人参皂苷；信号通路中图分类号：R285文献标识码：A文章编号：1001-4721（2023）03-0163-06Research Progress of Ginsenosides in the Treatment of OsteoarthritisGUO Xiaoyan1,ZHANG Weidong1,ZHANG Yang1※（School of Pharmaceutical Sciences,Jilin University,Changchun130021,China）Abstract:Ginseng has pharmacological effects such as anti-inflammatory,antioxidant,antidepressant,anti-Alzheimer's and anti-athero-sclerosis.Current studies have found that it has good therapeutic prospects in preventing degeneration of articular cartilage damage and parti-cipating in in vitro culture of chondrocytes to repair articular cartilage defects.Ginsenosides,as the main pharmacological active component of ginseng,also play an important role in the process of treating osteoarthritis.Ginsenosides can be classified into different types because of their different structures,and each type contains a variety of ginsenoside monomer components with different mechanisms for the treatment of osteoarthritis.In this paper,we review the research progress of different ginsenoside monomers in the treatment of osteoarthritis,and ex-plore their potential possibilities and mechanisms for the treatment of osteoarthritis,so as to provide a basis for later clinical application. Key words:osteoarthritis;ginsenosides;signaling pathway骨性关节炎（Osteoarthritis,OA）是一种退行性病变，系由于增龄、肥胖、遗传、劳损、创伤、关节先天性异常和关节畸形等诸多因素引起的关节软骨退化损伤、关节边缘和软骨下骨反应性增生。
高效液相色谱法测定大蒜提取物中蒜氨酸的含量
高效液相色谱法测定大蒜提取物中蒜氨酸的含量蒋利;常军民【摘要】目的建立高效液相色谱法测定大蒜提取物中蒜氨酸含量的方法 .方法采用YMC-Pack ODSA(250 mm×4.6 mm,5 μm)色谱柱;流动相:0.02%三氟乙酸水溶液;流速:0.5 mL·min-1;紫外检测波长:214 nm.结果在14.7～294 mg·L-1范围内,峰面积与蒜氨酸浓度呈较好的线性关系(r=0.999 9),平均回收率为100.1%,RSD 为2.0%(n=9).结论该法操作简便,重现性好,结果准确、可靠.【期刊名称】《西北药学杂志》【年(卷),期】2009(024)001【总页数】2页(P21-22)【关键词】大蒜;提取物;蒜氨酸;高效液相色谱法【作者】蒋利;常军民【作者单位】新疆医科大学药学院,新疆,乌鲁木齐,830011;新疆医科大学药学院,新疆,乌鲁木齐,830011【正文语种】中文【中图分类】R927.2大蒜为百合科葱属植物蒜(Allium Sativum Linn．)的干燥鳞茎，具有抗菌、抗病毒、预防心血管疾病和抗肿瘤等生物活性［1］。
蒜氨酸又名蒜碱，化学名为S－烯丙基－L－半胱氨酸亚砜［S－allyl－L－(+)－cysteine sulfoxide］，白色针状结晶，易溶于水，不溶于乙醚等非极性有机溶剂，以稳定、无臭形式存在于大蒜鳞芽中，是完整、未受损大蒜中含量最丰富的非蛋白类含硫氨基酸，是大蒜中主要的含硫化合物。
研究表明，蒜氨酸具有降血酯、抗动脉粥样硬化、提高机体免疫等功效［2，3］。
有关大蒜中蒜氨酸的含量测定已报道较多，但大蒜提取物中蒜氨酸的含量测定未见报道，因此笔者建立高效液相色谱法测定大蒜提取物中蒜氨酸的含量，为大蒜制剂的质量标准提供参考依据。
1．1 仪器岛津 LC－20A系列高效液相色谱仪，DAD检测器，岛津LC－20A色谱工作站;赛多利斯BP211型电子天平(德国)。
SCI_Chem 影响因子
Abbreviated JournalTitle(linked to journal information)Total CitesImpact Factor5-YearImpactFactor Immediacy Index综合1Nature 0028-0836********.59738.1599.2432Science0036-807550848931.02733.587 6.6913P Natl Acad Sci Usa 0027-84245349519.73710.583 1.893化学综合1Chem Rev 0009-266511259641.29845.79514.3352Nat Mater 1476-11224634835.74942.3768.4113Nat Nanotechnol 1748-33872192031.1736.011 5.8764Chem Soc Rev 0306-00124764624.89230.1817.9975Prog Mater Sci 0079-6425592123.19422.3337.2176Nat Chem 1755-4330865221.75723.02 5.5327Accounts Chem Res 0001-48424211220.83324.633 5.2958Nano Today 1748-0132294417.68918.1920.7849Annu Rev Mater Res 1531-7331525916.17914.4950.66710Surf Sci Rep 0167-5729411515.33322.2817.7511Adv Mater 0935-96489195214.82913.86 2.55712Mat Sci Eng R 0927-796X 485013.90218.9740.66713Angew Chem Int Edit 1433-785122989413.73413.56 2.95914Annu Rev Phys Chem 0066-426X 700213.36518.121 4.13815Nano Lett 1530-69848843113.02514.132 2.47116Acs Nano 1936-0851*******.06212.524 1.9417Energ Environ Sci 1754-56921284911.65312.462 3.08718Coordin Chem Rev 0010-85452560111.01612.257 2.29419J Am Chem Soc 0002-786343128610.67710.237 2.16420Nat Prod Rep 0265-0568660910.17810.072 2.38521Adv Energy Mater 1614-6832199510.04310.05 2.11822Adv Funct Mater 1616-301X 347589.76510.342 1.81523Med Res Rev 0198-632532979.5839.978 1.81124Npg Asia Mater 1884-40493019.0428.556 2.41425Annu Rev Anal Chem 1936-132711498.612.2830.69626Top Curr Chem 0340-102255078.456 6.205 4.27327Chem Sci 2041-652048458.3148.33 2.77128Chem Mater 0897-4756746518.2387.627 1.12329J Photoch Photobio C 1389-556720268.06911.9520.7530Small 1613-6810181377.8238.084 1.42931Prog Photovoltaics 1062-799545357.7127.023 3.22332J Control Release 0168-3659297557.6338.078 1.13633Annu Rev Chem Biomol 1947-54383317.5127.512 1.04534Int Mater Rev 0950-660822557.487.1491.188RankISSNJCR Data35Chemsuschem1864-563150567.4757.951 1.189 36Prog Solid State Ch0079-678614747.429 3.3380 37Nano Res1998-012430317.3927.8010.979 38Prog Surf Sci0079-681619047.1369.140.273 39Adv Carbohyd Chem Bi0065-23188337.133 5.8460.75 40Green Chem1463-926215554 6.828 6.992 1.269 41Adv Organomet Chem0065-3055841 6.758.9410 42Curr Opin Colloid In1359-02944670 6.6297.0360.884 43J Phys Chem Lett1948-71858575 6.585 6.651 1.301 44Top Organometal Chem1436-60021152 6.384 1.762 45Chem Commun1359-7345122728 6.378 6.226 1.53 46Catal Rev0161-49402529 6.37510.1750.889 47Trac-Trend Anal Chem0165-99367327 6.351 6.7610.92 48Nanoscale2040-33647835 6.233 6.262 1.167 49Adv Colloid Interfac0001-86867115 6.1698.01 1.32 50Org Lett1523-706073440 6.142 5.563 1.572 51Mater Today1369-70213769 6.0718.677 1.977 52Prog Nucl Mag Res Sp0079-65651993 6.022 6.065 1.389 53Crit Rev Solid State1040-8436744 5.9477.3681 54Carbon0008-622332742 5.868 6.35 1.197 55Chem-Eur J0947-653960788 5.831 5.623 1.241 56Appl Catal B-Environ0926-337323011 5.825 6.0310.965 57J Catal0021-951734516 5.787 6.249 1.025 58Wires Comput Mol Sci1759-0876570 5.738 5.738 3.518 59Lab Chip1473-019716485 5.697 6.136 1.256 60Anal Chem0003-270096794 5.695 5.7690.948 61J Med Chem0022-262359227 5.614 5.383 1.225 62Adv Synth Catal1615-415015502 5.535 5.323 1.109 63Curr Opin Solid St M1359-02862508 5.4387.3290.913 64Biosens Bioelectron0956-566322068 5.437 5.389 1.105 65J Chem Theory Comput1549-961811067 5.389 5.936 1.067 66Biomacromolecules1525-779724209 5.371 5.750.721 67Acs Catal2155-54351461 5.265 5.265 1.222 68Adv Catal0360-05641399 5.25 5.2860 69Chemcatchem1867-38802718 5.181 5.3070.941 70Mrs Bull0883-******** 5.024 5.590.569 71Acs Appl Mater Inter1944-82448635 5.008 5.040.683 72Electroanal Chem0070-977837757.50.25 73J Comb Chem1520-47662925 4.933 3.10274Int Rev Phys Chem0144-235X1524 4.92 5.595 2.231 75J Phys Chem C1932-744778595 4.814 5.1520.738 76Pharm Res-Dordr0724-874119035 4.742 5.0460.735 77Cryst Growth Des1528-748322310 4.689 4.8730.869 78Sol Energ Mat Sol C0927-024818447 4.63 5.205 1.215 79J Chromatogr A0021-967363419 4.612 4.5820.71480Inorg Chem0020-166985446 4.593 4.5510.956 81Bioconjugate Chem1043-180213900 4.58 4.7960.768 82Chem-Asian J1861-47286084 4.572 4.488 1.04683J Org Chem0022-326396723 4.564 4.135 1.101 84Anal Chim Acta0003-267039448 4.387 4.3440.684 85Chem Rec1527-89991375 4.377 4.814 1.533 86Int J Plasticity0749-64195276 4.356 4.70.862 87J Chem Inf Model1549-959611250 4.304 4.0670.795 88Langmuir0743-7463106920 4.187 4.4160.793 89Organometallics0276-733339735 4.145 3.653 1.004 90Ultraschall Med0172-46141247 4.116 2.723 1.286 91J Flow Chem2062-249X61 4.091 4.091 1.143 92Curr Med Chem0929-867312773 4.07 4.4710.627 93Struct Bond0081-59931899 4.068 4.24894Mar Drugs1660-33971871 3.978 3.9110.428 95Analyst0003-265416152 3.969 3.9040.785 96Acta Mater1359-645434860 3.941 4.3950.781 97Soft Matter1744-683X15943 3.909 4.35 1.013 98Crystengcomm1466-803312988 3.879 4.0690.863 99Acs Chem Neurosci1948-7193634 3.871 3.9570.729 100Nanotechnology0957-448434133 3.842 3.8380.697 101Org Electron1566-11995856 3.836 4.0210.63 102J Comput Chem0192-865124682 3.835 4.4010.847 103Phys Chem Chem Phys1463-907640969 3.829 3.976 1.052 104Faraday Discuss1359-66405758 3.821 4.148 2.369 105Dalton T1477-922638660 3.806 3.8890.947 106Catal Sci Technol2044-47531079 3.753 3.753 1.024 107Sci Technol Adv Mat1468-69962352 3.752 3.6440.235 108Chembiochem1439-42279616 3.74 3.670.78 109Curr Top Med Chem1568-02664850 3.702 3.8850.655 110Chem Res Toxicol0893-228X10785 3.667 4.0130.807 111Anal Bioanal Chem1618-264221971 3.659 3.7560.727 112Acs Comb Sci2156-8952379 3.636 3.6360.596 113Corros Sci0010-938X18210 3.615 4.0160.757 114J Phys Chem B1520-6106119722 3.607 3.7020.66 115J Am Soc Mass Spectr1044-03058760 3.592 3.5030.925 116J Cheminformatics1758-2946315 3.59 3.6710.314 117Org Biomol Chem1477-052018355 3.568 3.490.952 118Ultrasound Obst Gyn0960-76928490 3.557 3.7080.756 119Colloid Surface B0927-776510312 3.554 3.4170.707 120Int J Hydrogen Energ0360-319933119 3.548 4.0860.584 121Sensor Actuat B-Chem0925-400529909 3.535 3.6680.527 122Dyes Pigments0143-72087664 3.532 3.4330.897 123Expert Opin Ther Pat1354-37761742 3.525 2.5230.6 124Ultrason Sonochem1350-41775008 3.516 3.708 1.234125J Phys Chem Ref Data0047-26894996 3.5 3.7790.391 126Eur J Med Chem0223-523414818 3.499 3.8490.541 127Talanta0039-914026966 3.498 3.7330.531 128Food Hydrocolloid0268-005X6307 3.494 3.5250.953 129Drug Des Dev Ther1177-8881377 3.4860.256 130Carbohyd Polym0144-861718471 3.479 3.9420.665 131Microchim Acta0026-36724743 3.434 2.8830.5 132Appl Catal A-Gen0926-860X27726 3.41 3.910.506 133J Mech Phys Solids0022-509610460 3.406 3.7460.784 134Pure Appl Chem0033-454513333 3.386 3.1150.382 135Micropor Mesopor Mat1387-181115134 3.365 3.4140.869 136J Biol Inorg Chem0949-82574011 3.353 3.3550.713 137Chemphyschem1439-423511279 3.349 3.3880.768 138Eur J Org Chem1434-193X19346 3.344 3.1370.746 139Food Chem0308-814641375 3.334 4.0720.589 140Acs Med Chem Lett1948-58751087 3.311 3.3180.699 141Future Med Chem1756-89191081 3.31 3.2450.933 142J Nat Prod0163-386419898 3.285 3.2670.787 143Electrophoresis0173-083516985 3.261 2.8690.479 144Bioanalysis1757-61801318 3.253 3.0440.723 145J Mass Spectrom1076-51745573 3.214 3.2270.495 146J Inorg Biochem0162-013410014 3.197 3.430.672 147J Mol Catal A-Chem1381-116917999 3.187 3.3190.496 148J Colloid Interf Sci0021-979744929 3.172 3.390.747 149J Anal Atom Spectrom0267-94777362 3.155 2.9530.725 150Sep Purif Rev1542-2119222 3.154 3.5430.3 151J Pharm Sci-Us0022-354917986 3.13 3.3850.6 152Eur J Inorg Chem1434-194816310 3.12 2.9510.728 153Cement Concrete Res0008-884613854 3.112 3.7460.441 154Curr Org Chem1385-27283953 3.039 3.2220.253 155Isr J Chem0021-21481263 3.025 1.9460.478 156Mar Chem0304-420368723 3.3150.466 157Catal Today0920-586123325 2.98 3.4640.515 158Phytomedicine0944-71135244 2.972 3.2580.401 159New J Chem1144-054610014 2.966 2.920.698 160J Pharmaceut Biomed0731-708514648 2.947 2.8530.562 161Photoch Photobio Sci1474-905X4541 2.923 2.810.538 162Catal Commun1566-73679190 2.915 3.3280.535 163Mater Design0261-30699587 2.913 2.8050.703 164J Agr Food Chem0021-856176046 2.906 3.2880.417 165Bioorgan Med Chem0968-089624911 2.903 3.1510.617 166Crit Rev Anal Chem1040-8347979 2.892 3.690.591 167Microchem J0026-265X3428 2.879 2.85 1.048 168Mini-Rev Med Chem1389-55752893 2.865 2.9210.496 169Mol Divers1381-19911289 2.861 3.090.44170Chemmedchem1860-71793723 2.835 3.0750.788 171J Mol Catal B-Enzym1381-11774943 2.823 2.8050.542 172Scripta Mater1359-646219677 2.821 3.1450.534 173Adv Phys Org Chem0065-3160391 2.818 2.609174Electroanal1040-039710646 2.817 2.8620.462 175Fuel Process Technol0378-******** 2.816 3.4930.49 176Tetrahedron0040-402052981 2.803 2.8990.636 177Beilstein J Org Chem1860-53971405 2.801 2.4750.386 178J Phys Chem A1089-563955641 2.771 2.8560.658 179J Ethnopharmacol0378-874121278 2.755 3.3220.519 180Org Process Res Dev1083-61604311 2.739 2.6670.808 181J Supercrit Fluid0896-84466044 2.732 3.1380.472 182Medchemcomm2040-2503690 2.722 2.7220.603 183Adv Inorg Chem0898-******** 2.714 3.3780.25 184J Electroanal Chem1572-665721687 2.672 2.6760.545 185Int J Photoenergy1110-662X945 2.663 2.240.671 186Synlett0936-521417034 2.655 2.4520.604 187Environ Chem1448-25171390 2.652 2.701 1.075 188Opt Mater Express2159-3930593 2.616 2.6220.815 189Anti-Cancer Agent Me1871-52061386 2.610.239 190Top Catal1022-55284896 2.608 2.7080.238 191J Sep Sci1615-93068094 2.591 2.6380.296 192Anal Biochem0003-269739746 2.582 2.9690.558 193Rsc Adv2046-20691816 2.562 2.5670.695 194J Anal Appl Pyrol0165-23705102 2.56 3.0740.447 195Nanoscale Res Lett1931-75733998 2.524 2.7830.2980951-419813285 2.509 2.6110.49 196Rapid Commun Mass Sp196Sci Adv Mater1947-2935553 2.509 2.5610.301 198React Funct Polym1381-51484515 2.505 2.6530.282 199J Chem Technol Biot0268-25756796 2.504 2.4790.573 200Synthesis-Stuttgart0039-788117999 2.5 2.3840.615 201Microsc Microanal1431-92762043 2.495 3.0770.276 202J Chromatogr B1570-023220776 2.487 2.90.319 203Phytochem Analysis0958-03441895 2.48 2.280.292 204Adv Heterocycl Chem0065-2725888 2.478 2.6170.455 205Chem Biol Drug Des1747-02771940 2.469 2.4090.511 206Int J Mol Sci1422-00674706 2.464 2.7320.313 207Ultrasound Med Biol0301-56297839 2.455 2.8440.251 208Gold Bull0017-15571073 2.434 3.1220.04 209Molecules1420-30497552 2.428 2.6790.329 210Plasmonics1557-1955877 2.425 2.9880.525 211J Photoch Photobio A1010-603013061 2.416 2.6910.299 212Tetrahedron Lett0040-403973763 2.397 2.3760.561 213J Alloy Compd0925-838839264 2.39 2.1610.629 214Phys Status Solidi-R1862-62541437 2.388 2.4320.527215Fluid Phase Equilibr0378-******** 2.379 2.3380.544 216Solvent Extr Ion Exc0736-******** 2.375 2.6090.345 217Beilstein J Nanotech2190-4286309 2.374 2.3740.573 218Plant Food Hum Nutr0921-96681569 2.358 2.7620.25 219Acta Pharmacol Sin1671-40835577 2.354 2.5210.596 220Planta Med0032-094311009 2.348 2.4620.304 221Appl Clay Sci0169-13175590 2.342 2.7980.337 222Bioorg Med Chem Lett0960-894X33460 2.338 2.4270.584 222Macromol Mater Eng1438-74922983 2.338 2.3920.509 222Mol Inform1868-1743344 2.338 2.3460.347 225Russ Chem Rev+0036-021X3092 2.299 2.8130.204 226J Chem Thermodyn0021-96145905 2.297 2.2560.735 227Constr Build Mater0950-06187337 2.293 2.8180.391 228Chemometr Intell Lab0169-74394880 2.291 2.4320.253 229Biophys Chem0301-46224822 2.283 2.0940.649 230Arab J Chem1878-5352299 2.2660.343 231J Ginseng Res1226-8453349 2.2590.34 232Materials1996-19441176 2.247 2.3380.222 233Catal Lett1011-372X9373 2.244 2.2610.351 234Theor Chem Acc1432-881X5484 2.233 3.1510.812 235Fitoterapia0367-326X4706 2.231 2.1390.349 236Mater Lett0167-577X23419 2.224 2.3220.489 237Food Addit Contam A1944-00495142 2.22 2.4420.508 238J Biomol Screen1087-05712357 2.207 2.0890.719 239Platin Met Rev0032-1400735 2.194 2.4760.579 240J Nanopart Res1388-07645724 2.175 2.7210.222 241J Mater Sci0022-246131538 2.163 2.10.543 242Adv Quantum Chem0065-3276869 2.161 1.6940.308 242Colloid Polym Sci0303-402X5657 2.161 2.1140.433 244Chem Phys Lett0009-261455163 2.145 2.150.485 244J Ind Eng Chem1226-086X2264 2.145 1.9550.329 246Tetrahedron-Asymmetr0957-416611707 2.115 2.1430.384 247Appl Surf Sci0169-433231193 2.112 2.0990.33 248Synthetic Met0379-677913916 2.109 2.1020.334 249Colloid Surface A0927-775718414 2.108 2.3330.333 249Mat Sci Eng A-Struct0921-509340513 2.108 2.3490.307 251J Anal Toxicol0146-47602660 2.107 1.7580.429 252Solid State Nucl Mag0926-20401202 2.1 2.0570.711 253J Food Compos Anal0889-15753737 2.088 2.7430.19 254J Environ Monitor1464-03254378 2.085 2.1370.322 255Mater Chem Phys0254-058417174 2.072 2.3950.286 256J Pept Sci1075-26171942 2.071 1.8280.434 257Phytother Res0951-418X8059 2.068 2.4380.444 258Nano-Micro Lett2150-5551205 2.057 1.910.35 259Solid State Ionics0167-273820728 2.046 2.5640.26260Carbohyd Res0008-621514176 2.044 2.1780.357 261J Solid State Chem0022-459618166 2.04 2.2950.392 262Curr Org Synth1570-1794673 2.038 2.9140.76 263Ultrasonics0041-624X3651 2.028 2.0540.456 264Smart Mater Struct0964-17267120 2.024 2.3770.289 265Inorg Chem Commun1387-70036416 2.016 1.8810.434 266Appl Organomet Chem0268-26052866 2.011 1.9220.272 267Electrochem Solid St1099-00628883 2.01 2.0260.596 268J Chem Eng Data0021-956815169 2.004 2.1150.295 269Comb Chem High T Scr1386-207314532 1.9750.268 269J Organomet Chem0022-328X217932 1.9920.527 271Thermochim Acta0040-603111408 1.989 2.0460.327 272J Mol Model1610-29403157 1.984 2.3010.378 273J Therm Anal Calorim1388-61509934 1.982 1.7420.243 274Int J Fatigue0142-11235248 1.976 1.9740.352 275J Vib Control1077-54631649 1.966 1.7360.672 276Chem Phys0301-010412935 1.957 2.0590.592 277J Mater Process Tech0924-013618426 1.953 2.1760.332 277Sensors-Basel1424-82207082 1.953 2.3950.321 279Biomed Chromatogr0269-38792861 1.945 1.8150.385 280J Fluorine Chem0022-11394998 1.939 1.9490.465ArticlesCited Half-life Eigenfactor ®Metrics ScoreArticleInfluenc e® Score8699.6 1.5750820.8448329.7 1.3598717.71238018 1.55663 4.8921768.20.2266114.294141 5.20.2278819.481121 3.70.1543615.607390 3.50.178418.8542370.015018.643126 2.40.054018.927207 6.50.108177.90837 3.20.01489 5.62318>10.00.013647.55389.40.008828.821867 5.10.27819 4.24368.40.00872 6.542227 5.50.53637 3.497299.90.01888.1211078 4.40.37491 5.1891191 2.40.20333 4.012473 1.80.05534 3.461368.20.03818 3.07130997.70.83183 2.99465 5.90.01757 3.141169 1.40.00944 3.344569 4.20.12336 3.006377.20.00647 2.73229 1.90.00155 3.27323 3.90.00716 4.441557.70.01045 2.068458 1.40.02121 2.833576 6.70.15215 2.032167.90.00342 3.148457 3.60.07856 2.503112 4.60.01202 1.97501 6.90.05008 1.9062220.00197 2.73916>10.00.003282.792Eigenfactor®Metrics286 2.60.0208 2.0046>10.00.00142 1.13896 2.80.01517 2.301119.20.00397 3.974>10.00.00086 1.894 44940.03848 1.5233>10.00.00076 2.537437.60.01013 2.301 63220.04884 2.393 2150.003483173 4.80.28954 1.5629>10.00.00211 3.009 138 5.80.01695 1.794 1015 1.70.02966 1.597 508.20.01226 2.37 160850.18182 1.40244 5.40.01448 3.213188.30.00431 2.295 107.10.00156 2.34 674 6.40.06437 1.6 1916 4.10.1766 1.469 480 5.40.05059 1.419 284>10.00.04014 1.60356 1.20.00194 1.703 617 3.70.05475 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1478 4.10.10840.548 14830.008560.8753427.80.015630.587 559.80.002470.6496 1.50.001250.668648.10.002270.561 178 6.20.010850.6 247>10.00.011750.526 202 5.20.013550.701 1484 5.40.069550.546 116 6.40.005740.60572 2.10.00140.58954>10.00.004010.856 351 6.60.011110.57 960 3.90.021660.681 1549.50.006150.597 5790.008180.646 6720.0008353 2.30.00061176 2.60.005320.633 1947.80.016490.569 223 5.60.014960.968 25280.006360.457 1626 5.50.049760.537 1977.10.008730.585 128 5.40.00580.57919>10.00.001080.734 650 3.70.017210.673 9419.10.050830.59113>10.00.00130.598 21090.007690.475 906>10.00.066080.687 350 3.90.005590.396 2247.80.01640.479 1789 5.50.074220.539 419>10.00.014550.491 579 6.80.034280.585 11717.30.084950.73 918.60.003920.471 458.60.00220.655 100 6.20.007370.666 335 5.10.012850.644 964 5.50.038290.59199 5.20.004810.478 302 6.60.012460.48640 2.10.000610.345 392>10.00.021350.719339>10.00.01560.489 5138.90.025150.615 50 4.50.001620.659 1368.50.005580.639 353 5.90.018730.713 495 4.80.011170.321 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益生菌对阿尔茨海默病作用的研究进展
益生菌对阿尔茨海默病作用的研究进展发布时间：2021-12-14T06:08:15.523Z 来源：《中国结合医学杂志》2021年12期作者：宋鑫萍1,2，李盛钰2，金清1[导读] 阿尔茨海默病已成为威胁全球老年人生命健康的主要疾病之一，患者数量逐年攀升，其护理的经济成本高，给全球经济造成重大挑战。
近年来研究显示，益生菌在适量使用时作为有益于宿主健康的微生物，在防治阿尔茨海默病方面具有积极影响，其作用机制可能通过调节肠道菌群，影响神经免疫系统，调控神经活性物质以及代谢产物，通过肠-脑轴影响该病发生和发展。
宋鑫萍1,2，李盛钰2，金清11.延边大学农学院，吉林延吉 1330022.吉林省农业科学院农产品加工研究所，吉林长春 130033摘要：阿尔茨海默病已成为威胁全球老年人生命健康的主要疾病之一，患者数量逐年攀升，其护理的经济成本高，给全球经济造成重大挑战。
近年来研究显示，益生菌在适量使用时作为有益于宿主健康的微生物，在防治阿尔茨海默病方面具有积极影响，其作用机制可能通过调节肠道菌群，影响神经免疫系统，调控神经活性物质以及代谢产物，通过肠-脑轴影响该病发生和发展。
本文综述了近几年来国内外益生菌对阿尔茨海默病的作用进展，以及其预防和治疗阿尔茨海默病的潜在作用机制。
关键词：益生菌；阿尔茨海默病；肠道菌群；机制Recent Progress in Research on Probiotics Effect on Alzheimer’s DiseaseSONG Xinping1,2，LI Shengyu2，JI Qing1*(1.College of Agricultural, Yanbian University, Yanji 133002，China)(2.Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Chanchun 130033, China)Abstract：Alzheimer’s disease has become one of the major diseases threatening the life and health of the global elderly. The number of patients is increasing year by year, and the economic cost of nursing is high, which poses a major challenge to the global economy. In recent years, studies have shown that probiotics, as microorganisms beneficial to the health of the host, have a positive impact on the prevention and treatment of Alzheimer’s disease. Its mechanism may be through regulating intestinal flora, affecting the nervous immune system, regulating the neuroactive substances and metabolites, and affecting the occurrence and development of the disease through thegut- brain axis. This paper reviews the progress of probiotics on Alzheimer’s disease at home and abroad in recent years, as well as its potential mechanism of prevention and treatment.Key words：probiotics; Alzheimer’s disease; gut microbiota; mechanism阿尔茨海默病（Alzheimer’s disease, AD），系中枢神经系统退行性疾病，属于老年期痴呆常见类型，临床特征主要包括：记忆力减退、认知功能障碍、行为改变、焦虑和抑郁等。
依达拉奉右莰醇注射液对急性大动脉粥样硬化型脑梗死患者炎症反应及不良反应的影响
DOI：10.19368/ki.2096-1782.2023.07.113依达拉奉右莰醇注射液对急性大动脉粥样硬化型脑梗死患者炎症反应及不良反应的影响冯学才山东省聊城市肿瘤医院内科，山东聊城252000[摘要]目的探讨依达拉奉右莰醇注射液用于急性大动脉粥样硬化型脑梗死患者治疗中的临床效果。
方法选取2021年8月—2022年8月聊城市肿瘤医院收治的92例急性大动脉粥样硬化型脑梗死患者为研究对象，基于“简单随机化方法”规范化分组处理，划分为对照组（实行脑梗死常规治疗）与观察组（实行脑梗死常规治疗+依达拉奉右莰醇注射液治疗），每组46例；观察对比两组临床疗效及不良反应发生率、神经功能缺损及预后情况、血清炎症因子和氧化应激水平。
结果观察组治疗总有效率为95.65%，显著高于对照组的82.61%，差异有统计学意义（χ2=4.039，P<0.05）。
两组不良反应发生率比较，差异无统计学意义（P>0.05）。
治疗3个月后，观察组NIHSS、mRS评分较对照组更低，差异有统计学意义（P<0.05）。
治疗后，两组hs-CRP、MMP-9、MDA水平均下降，SOD水平均升高，其中观察组更优，差异有统计学意义（P<0.05）。
结论急性大动脉粥样硬化型脑梗死患者应用依达拉奉右莰醇注射液，可抑制机体炎症反应及氧化应激反应，改善脑部血供，促进神经功能恢复，提高预后，其治疗安全性及有效性兼顾。
[关键词]依达拉奉右莰醇注射液；大动脉粥样硬化型；脑梗死；炎症反应；不良反应[中图分类号]R742 [文献标识码]A [文章编号]2096-1782（2023）04(a)-0113-05Effects of Edaravone Dextran Injection on Inflammatory Response and Ad⁃verse Reactions in Patients with Acute Large Artery Atherosclerotic Cere⁃bral InfarctionFENG XuecaiDepartment of Internal Medicine, Liaocheng Cancer Hospital, Liaocheng, Shandong Province, 252000 China[Abstract] Objective To investigate the clinical effects of edaravone dextran injection in the treatment of patients with acute large artery atherosclerotic cerebral infarction. Methods 92 patients with acute cerebral infarction of Ath⁃erosclerosis type admitted to Liaocheng Cancer Hospital from August 2021 to August 2022 were selected as the re⁃search objects. Based on the standardized grouping treatment of "simple randomization method", they were divided into a control group (routine treatment of cerebral infarction) and an observation group (routine treatment of cerebral infarction+Edaravone and right camphor injection), with 46 cases in each group. The clinical efficacy and rate of ad⁃verse reactions, neurological deficits and prognosis, serum inflammatory factors and oxidative stress levels were ob⁃served and compared between the two groups. Results The total effective rate of treatment in the observation group was 95.65%, which was statistically significantly higher than that of 82.61% in the control group, and the difference was statistically significant (χ2=4.039, P<0.05). There was no statistically significant difference in the rate of adverse reactions between the two groups (P>0.05). After 3 months of treatment, the NIHSS and mRS scores in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treat⁃ment, hs-CRP, MMP-9, and MDA levels decreased and SOD levels increased in both groups, with the observation[作者简介] 冯学才（1976-），男，本科，副主任医师，研究方向为内科疾病诊疗等。
德谷门冬双胰岛素注射液治疗2_型糖尿病临床效果及安全性探讨
DOI：10.16658/ki.1672-4062.2023.17.098德谷门冬双胰岛素注射液治疗2型糖尿病临床效果及安全性探讨林生，谢平，陈予福州市长乐区人民医院内分泌科，福建福州350200[摘要]目的研究德谷门冬双胰岛素注射液治疗2型糖尿病的临床效果及安全性。
方法选取于2022年7月—2023年4月福州市长乐区人民医院收治的2型糖尿病患者98例为研究对象，采用随机抓阄法分为两组，每组49例。
两组均联用常规降糖药物治疗，对照组采用甘精胰岛素注射液治疗，观察组采用德谷门冬双胰岛素注射液治疗。
对比两组临床治疗效果、临床症状好转时间和胰岛素用量情况、糖代谢指标、胰岛素功能指标、不良反应发生情况、心血管不良事件发生情况。
结果观察组总有效率高于对照组，差异有统计学意义（P<0.05）。
观察组尿酮体转阴时间、血糖达标时间、胰岛素用量均优于对照组，差异有统计学意义（P< 0.05）。
观察组空腹血糖、餐后2 h血糖、糖化血红蛋白均低于对照组，差异有统计学意义（P<0.05）。
观察组胰岛β细胞功能指数高于对照组，胰岛素抵抗指数、空腹胰岛素低于对照组，差异有统计学意义（P<0.05）。
两组恶心呕吐、倦怠乏力、低血糖总发生率比较，差异无统计学意义（P>0.05）。
两组心绞痛、心力衰竭总发生率比较，差异无统计学意义（P>0.05）。
结论德谷门冬双胰岛素注射液治疗2型糖尿病临床效果显著优于甘精胰岛素注射液，但是治疗安全性无显著变化。
[关键词] 2型糖尿病；德谷门冬双胰岛素注射液；不良反应；心血管不良事件[中图分类号] R59 [文献标识码] A [文章编号] 1672-4062（2023）09（a）-0098-04Discussion on the Clinical Effect and Safety of Insulin Degludec and Insu⁃lin Aspart Injection in the Treatment of Type 2 Diabetes MellitusLIN Sheng, XIE Ping, CHEN YuDepartment of Endocrinology, Changle District People's Hospital, Fuzhou, Fujian Province, 350200 China[Abstract] Objective To study the clinical effect and safety of insulin degludec and insulin aspart injection in the treatment of type 2 diabetes mellitus. Methods A total of 98 patients with type 2 diabetes admitted to Fuzhou Changle District People's Hospital from July 2022 to April 2023 were selected as the study objects and divided into two groups with 49 cases in each group by random lottery method. Both groups were treated with conventional hypoglycemic drugs, the control group was treated with insulin glargine injection, and the observation group was treated with Degu asparton double insulin injection. The clinical therapeutic effect, time of improvement of clinical symptoms, insulin dosage, glucose metabolism index, insulin function index, occurrence of adverse reactions and cardiovascular adverse events were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The time of urine ketone body turning negative, blood glucose reaching standard and insulin dosage in observation group were better than those in control group, and the differences were statistically significant (P<0.05). Fasting plasma glucose, 2-hour postprandial blood glucose and glycated hemoglobin in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). The function index of islet β cells in observation group was higher than that in control group, the insulin resistance index and fasting insulin was lower than that in control group, the dif⁃ference was statistically significant (P<0.05). There was no statistically significant difference in the total incidence of [作者简介]林生（1981-），男，本科，副主任医师，研究方向为糖尿病及其并发症的相关临床研究。