捷诺达说明书
KOD Dash 2109使用手册说明书
F0939K KOD DashLDP-101 250 U 200 reactionsStore at -20°C Contents[1]Introduction[2]Components[3]Quality testing[4]Primer design[5]Cloning of PCR products[6]Protocol1. Standard reaction setup2. Cycling conditions[7]Examples[8]Troubleshooting[9] Related products[10] ReferencesC AUSIONAll reagents in this kit are intended for research purposes. Do not use for diagnosis or clinical purposes. Please observe general laboratory precaution and utilize safety while using this kit.JAPAN CHINATOYOBO CO., LTD. TOYOBO Bio-Technology, CO., LTD.Tel(81)-6-6348-3888 Tel(86)-21-58794900.4140www.toyobo.co.jp/e/bio 1JAPAN CHINATOYOBO CO., LTD. TOYOBO Bio-Technology, CO., LTD. Tel(81)-6-6348-3888 Tel(86)-21-58794900.4140www.toyobo.co.jp/e/bio **********************1[ 1 ] Introduction [ 2 ] Components DescriptionKOD Dash is a highly efficient DNA polymerase mixture developed based on the Barns’ method1). This method uses a DNA polymerase which lacked a 3’♑5’ exonuclease (proofreading) activity and a small amount of an archaeal DNA polymerase with proofreading activity. In the reagent, the 3’♑5’ exonuclease activity-deficient mutant <KOD EXO(-)> of KOD DNA polymerase2)and KOD DNA polymerase are used. Because the proofreading activity repairs misincorporated nucleotide bases causing the termination of a polymerase reaction, PCR with this mixed enzyme solution enables highly efficient amplification.KOD Dash generates dA overhang-ended PCR products. Therefore, the PCR products can be cloned using a standard TA cloning method.Features-This enzyme mixture is effective for the amplification of various targets from a small template amount. The elongation ability of this enzyme mixture is much greater than that of the normal Taq DNA polymerase.-This enzyme mixture shows greater elongation velocity than Taq DNA polymerase (2 folds) and Pfu DNA polymerase (6 folds) due to the property of KOD DNA polymerase. -The PCR error ratio of this enzyme mixture is approximately 3 to 4 times less than that of Taq DNA polymerase.Fig. 1. The principles of the Barns’ technology.The provided reagents include the following components for 200 reactions:KOD Dash (2.5 U/μl) 100 μl10x PCR Buffer for KOD Dash* 1.2 ml2 mM dNTPs 1.0 ml*The final Mg concentration in the reaction mixture is 1.2 mM.JAPAN CHINATOYOBO CO., LTD. TOYOBO Bio-Technology, CO., LTD. Tel(81)-6-6348-3888 Tel(86)-21-58794900.4140www.toyobo.co.jp/e/bio **********************2[ 3 ] Quality Testing[ 4 ] Primer Design[ 5 ] Cloning ofPCR products [ 6 ] Protocol A quality check was performed by amplifying the human β-globin gene (8.5 kb) and the lambda phase gene (12 kb).PCR primers should be designed according to general guidelines. For the amplification ofa long target (≥ 4 kb), the melting temperature (Tm) of the primers should be set over72 °C.The PCR products obtained with amplification by KOD Dash can be cloned according toa standard TA-cloning method.1. Standard reaction setupThe following procedures have been designed for use with the components provided in this kit. Before preparing the reaction mixture, all components should be completely thawed, except for the enzyme solution.*10x Buffer may precipitate. If precipitation occurs, dissolve it completely by overturning and mixing before use. The precipitate on the bottom of the tube can be easily dissolved by tapping it and then mixing it with the solution. If the precipitate is difficult to dissolve, repeat both heating the reagent at 50℃ for 5 min and mixing it. Before preparing the reaction solution, mix each reagent thoroughly before use.* Do not use dNTPs from other kits or companies.Notes:-Thin-wall tubes are recommended for PCR use. A total reaction volume of 50 μl is recommended.-For amplification of a long target (≥ 8 kb), the use of a final concentration of 0.35 mM dNTPs may reduce non-specific amplification.Component Volume Final Concentration10x Buffer for KOD Dash 5 μl 1x2 mM dNTPs* 5 μl 0.2 mM each10 pmol/μl Primer #1 1 μl 0.2 μM10 pmol/μl Primer #2 1 μl 0.2 μMTemplate DNAX μlGenomic DNA 10-1000 ng/50 μlPlasmid DNA 1-50 ng/50 μlcDNA ≤1 μg （RNA equiv.)/50 μlE. coli cells (small amount)PCR grade water Y μlKOD Dash (2.5 U/μl) 0.5 μl 1.25 U / 50 μlTotal reaction volume 50 μlJAPAN CHINATOYOBO CO., LTD. TOYOBO Bio-Technology, CO., LTD. Tel(81)-6-6348-3888 Tel(86)-21-58794900.4140www.toyobo.co.jp/e/bio **********************3[ 7 ] Examples2. Cycling conditionsThe following cycling steps are recommended.(1) Cycling conditions for < 4kb targets.*Tm value of the primer minus 0°C-5°C(2) Cycling conditions for ≥ 4kb products.Note : If the Tm value of the primer is under 70 °C, the 3-step cycle is recommended.Notes:-Extension time should be set at 30 sec. per 1 kb of target length.-For colony-direct PCR, the pre-denaturation step should be set for 4 min. Example 1．Colony-direct PCR using E. coli cells.< 3-step cycle >Pre-denaturation 94 °C, 0-2 minDenaturation 94 °C, 30 sec.Annealing Tm-[0-5] o C*, 1-5 sec.Extension 74 °C, 30 sec./kb< 2-step cycle >Pre-denaturation 94 °C, 0-2 minDenaturation 94 °C, 30 sec.Extension 68-70 °C, 30 sec./kb25-35 cycles25-35 cyclesM 1 2 3 4Lane 1: Insert (+)Lane 2: Insert (-)Lane 3: Insert (+)F primer: TCGAGGTCGACGGTATCGAT (20mer GC=55%)R primer: CGCTCTAGAACTAGTGGATC (20mer GC=50%)JAPAN CHINATOYOBO CO., LTD. TOYOBO Bio-Technology, CO., LTD. Tel(81)-6-6348-3888 Tel(86)-21-58794900.4140 www.toyobo.co.jp/e/bio **********************4[ 8 ] Troubleshooting[ 9 ] Related products[ 10 ] References1) Barns WM, Proc. Natl. Acad. Sci. USA, 91: 2216-2220 (1994)2) Takagi M, Nishioka M, Kakihara H, Kitabayashi M, Inoue H, Kawakami B, Oka M, and Imanaka T, Appl Environ Microbiol ., 63: 4504-10 (1997)Product namePackage Code No. Highly efficient cDNA synthesis kitReverTra Ace ® - -100 rxns FSK-101 Highly efficient reverse transcriptaseReverTra Ace ®10,000 U TRT-101 RNase inhibitor (Recombinant type)2,500 U SIN-201 Highly efficient Taq DNA polymeraseBlend Taq ®250 U BTQ-101 Highly efficient Taq DNA polymerase (Hot start version)Blend Taq ®-Plus-250 U BTQ-201 High fidelity PCR enzymeKOD -Plus-200 U KOD-201 Highly reliable PCR enzymeKOD FX200 UKFX-101SymptomsCauseSolutionsNo PCR product / low yieldCycling conditions are not optimal Lower annealing temperature increments to a maximum of Tm-10 °C.Increase the number of cycles by 2-5 cycles.Primers are not goodCheck the design and/or quality of primers. Too much E. coli cells (Colony direct PCR)Decrease the amount of E. coli cells from colonies. Smearing / extra band(s)Cycling conditions are not optimalDecrease the number of cycles by 2-5 cycles.。
TC9新000-NDA说明书
(请务必在使用之前阅读)为了安全使用本产品▲在安装和使用之前，请务必详细阅读本说 明书，一定要注意安全，正确使用本产品， 并遵守本说明书中的各种规定。
▲基于VDE 0160。
本张力控制器是采用CPU 控制的电子设备，用来控制设备的张力， 所以要严格遵守电子设备有关规定和法则，适用标准，进行搬运安装操作和维护。
在打开控制器准备安装和接线之前要断开控制器电源至少要5分钟。
正确的配置和安装是控制器正常运行的前提。
对以下几点要特别注意：● 容许保护等级：保护接地，只有正确连接保护接地，才能减少外界电磁干扰。
●安装工作必须在无电状态下进行。
●与电网断开后，要等电容放电完毕，才可进行操作。
●不要让任何异物进入驱动器内。
●在使用前，要除去所有覆盖物，以防止装置过热。
●切勿在易燃易爆等危险环境中使用。
●请勿将本产品安装在高温、潮湿等恶劣环境下。
● 请勿将产品直接安装在易受震动冲击的环境中。
● 任何单位部门(Kortis 和Kortis 指定公司除外)未经允许不得擅自拆卸、修理、更改产品。
※注意：Kortis对由于不遵守本说明或适用规则而造成的损坏概不负责。
危险如果错误操作，将会产生危险情况，导致死亡或受重伤。
注意如果错误操作，将会产生危险情况，造成设备损坏或财产损失。
设计注意事项1.1 概述TC9000-NDA型张力控制器是一种高精度数字式可以自动控制卷材张力的自动控制仪器，它可以控制材料的放卷、送料、牵引及收卷张力。
1.2 功能及特点●采用16位高精度A/D转换器，传感器采样精度高，响应快。
●模糊PID控制，输出精度高达0.1%，张力控制更精确。
●可以直接驱动磁粉（电磁）离合器/制动器，也可控制变频、伺服等。
●可以接收传感器输入信号，自动调零，自动标定。
●人性化界面设计，操作十分方便。
●多行液晶显示，中英文菜单，编程简单，方便明了。
●内有密码功能，可以避免误操作改变设定参数。
●带有储存盒，可以将各种参数进行备份。
捷诺达,强强联合卓越降糖
▪ 两药联合低血糖发生风险低
Adapted from Williams-Herman et al, Poster presentation IDF 19th World Diabetes Congress, South Africa, 2006; Nauck MA, et al
UKPDS:血糖随着单药治疗时间延长而逐渐恶化
单药治疗：胰岛素、磺脲类或二甲双胍 9
8
平均 HbA1c (%)
7
6
0 0
3
6
随机化后时间（年）
传统治疗 (n=200)
氯磺丙脲 (n=129) 格列苯脲 (n=149) 二甲双胍 (n=181) 胰岛素 (n=199)
9
新诊断的超重2型糖尿病患者.
传统治疗 = 饮食治疗; UKPDS = UK Prospective Diabetes Study
胰高糖素
从α 细胞(GLP-1) 葡萄糖依赖性
↑胰岛素 ↓胰高糖素 减少肝糖输出
DPP-4 = dipeptidyl peptidase 4
Adapted from Brubaker PL, Drucker DJ Endocrinology 2004;145:2653–2659; Zander M et al Lancet 2002;359:824–830; Ahrén B Curr Diab Rep 2003;3:365–372; Buse JB et al. In Williams Textbook of
16 现在是16页\一共有53页\编辑于星期五
DPP-4 抑制剂和二甲双胍的联合治疗 机制互补，较少副反应
通过肠促胰岛激素作用增加胰岛素分 泌
改善胰岛素抵抗
DURAG+LX200中文手册
D−LX 200 D−LX 720 一体化火焰检测器任何工作开始前,请先阅读说明书!DURAG GmbH · Kollaustraße 105 · 22453 Hamburg · www.durag.de目录目录1声明····················································································3 概述1.1 印刷符号惯例.....................................................................5 1.2 安全..............................................................................6 1.3 使用意图.........................................................................8 1.4 在发生系统故障时防止间接损害..................................................8 1.5 人员资质..............................................................v. (9)1.6 出厂设置和可选设置······························································9 使用2.1 前提条件········································································10 2.2 相关认证········································································12 装配···················································································13 安装4.1 安装地点选择指导·······························································14 4.2 法兰安装········································································14 4.3 电气连接········································································15 4.4 电缆及屏蔽······································································17 4.5 吹扫风供应······································································17 4.6 调试步骤········································································18 设置5.1 门限开关········································································20 5.2 电流增益········································································21 5.3 测量通道········································································23 5.4 通讯地址········································································23 5.5 安全时间········································································25 5.6 设置过程········································································26 5.7 设置流程图······································································27 拆卸6.1 拆卸方法········································································28 6.2 拆卸过程········································································29 故障7.1 错误信息········································································31 技术数据8.1 基本型技术数据.................................................................32 8.2 防爆型技术数据.................................................................33 8.3 出厂设置........................................................................34 设备外形尺寸图9.1 D-LX200........................................................................35 9.2 D-LX720........................................................................36 9.3 D-LX200Ex......................................................................37 9.4 D-LX720Ex. (38)23 4567 89声明郑重声明本手册由DURAG整理，为DURAG公司生产的D-LX200,D-LX720系列产品的简化版手册，仅供现场调试人员参考使用。
METTLER TOLEDO IND690-Form终端说明书
Formula Ident B Components Ident D Ident E Ident F
• Rugged, waterproof housing, protected to IP69K • BIG WEIGHT® display – for easy reading, even from a great
Time is money – and you can save both with the IND690form With expensive labour costs and valuable materials, the IND690form is particularly economical. The powerful software, combined with accurate scales, prevents complaints about incorrect proportioning. METTLER TOLEDO offers tailor-made scales and terminals, ranging from industrial precision balances with an internal resolution of 3.2 million points, to competitively priced strain gauge/analogue weighing platforms with measuring ranges from milligrammes to tonnes.
pensed into a separate container. Each
formula and component can be provided
with an identification.
Richtek RT9194 低滴通线性调压器控制器说明书
Test CircuitFigure 1. Typical Test CircuitFigure 2. DRI Source/Sink Current Test CircuitV CC VOUTV CC DRIAbsolute Maximum Ratings (Note 1)z Supply Input Voltage, V CC-----------------------------------------------------------------------------------------15Vz Enable Voltage-------------------------------------------------------------------------------------------------------7Vz Power Good Output Voltage---------------------------------------------------------------------------------------7Vz Power Dissipation, P D @ T A = 25°CSOT-23-6---------------------------------------------------------------------------------------------------------------0.4Wz Package Thermal ResistanceSOT-23-6, θJA---------------------------------------------------------------------------------------------------------250°C/Wz Lead Temperature (Soldering, 10 sec.)-------------------------------------------------------------------------260°Cz Junction T emperature-----------------------------------------------------------------------------------------------150°Cz Storage T emperature Range---------------------------------------------------------------------------------------−65°C to 150°C z ESD Susceptibility (Note 2)HBM (Human Body Mode)-----------------------------------------------------------------------------------------2kVMM (Machine Mode)------------------------------------------------------------------------------------------------200V Recommended Operating Conditions (Note 3)z Supply Input Voltage, V CC-----------------------------------------------------------------------------------------4.5V to 13.5Vz Enable Voltage-------------------------------------------------------------------------------------------------------0V to 5.5Vz Junction T emperature Range--------------------------------------------------------------------------------------−40°C to 125°C z Ambient T emperature Range--------------------------------------------------------------------------------------−40°C to 85°C Electrical CharacteristicsTo be ContinuedTypical Operating CharacteristicsQuiescent Current vs. Temperature0.450.460.470.480.490.5-50-25255075100125Temperature Q u ie s c e n t C u r r e n t (m A )(°C)Feedback Voltage vs. Temperature0.70.750.80.850.9-50-25255075100125Temperature F e e d b a c k V o l t a g e (V )(°C)R e f e r t o T e s t C i r c u i t F i g u r e 1PGOOD Delay Time vs. Temperature1.522.533.54-50-25255075100125Temperature P G O O D D e l a y T i m e (m s )(°C)DRI Sink Current vs. Temperature12151821242730-50-25255075100125Temperature D R I S i n k C u r r e n t (m A )(°C)Sink Current vs. DRI Voltage05101520250.511.522.53DRI Voltage (V)S i n k C u r r e n t (m A )DRI Source Current vs. Temperature354045505560-50-25255075100125Temperature D R I S o u r c e C u r r e n t (m A )(°C)R e f e r t o T e s t C i r c u i t F i g u r e 1Load Transient Response020-205V IN = 2.5V, V OUT = 1.2V C IN = C OUT = 100uF Time (50us/Div)V CC = 12VC IN = C OUT = 100uFR e f e r t o T e s t C i r c u i t F i g u r e 1I Load (A)V EN (V)V OUTV PGOODV CC = 12V, C IN = C OUT = 100uF , I LOAD = 100mAR e f e r t o T e s t C i r c u i t F i g u r e 1V EN (V)V OUT V PGOODR e f e r t o T e s t C i r c u i t F i g u r e 1Capacitors SelectionCareful selection of the external capacitors for RT9194 is highly recommended in order to remain high stability and performance.Regarding the supply voltage capacitor, connecting a capacitor which is 1μF between V CC and ground is a must. The capacitor improves the supply voltage stability to provide chip normally operating.Regarding the input capacitor, connecting a capacitor which 100μF between V IN and ground is recommended to increase stability. With large value of capacitance could result in better performance for both PSRR and line transient response.When driving external pass element, connecting a capacitor 100μF between V OUT and ground is recommended for stability. With larger capacitance can reduce noise and improve load transient response and PSRR.Output Voltage SettingThe RT9194 develop a 0.8V reference voltage; especially suit for low voltage application. As shown in application circuit, the output voltage could easy set the output voltage by R1 & R2 divider resistor.Power Good FunctionThe RT9194 has the power good function with delay. The power good output is an open drain output. Connect a 100kΩ pull up resistor to V OUT to obtain an output voltage. When the output voltage arrive 90% of normal value the power good will output voltage with 3ms delay time.When the output voltage falling arrive 75% of normal value the power good will turn off with less than 1ms delay time. But, there are two exceptions. One is the enable pull low the power good will turn off quickly. The second is the V CC falling arrive POR value (4V typ.) the power good also will turn off quickly.Chip Enable OperationPull the EN pin low to drive the device into shutdown mode. During shutdown mode, the standby current drops to 5μA(MAX). The external capacitor and load current determine the output voltage decay rate. Drive the EN pin high to turn on the device again.Under Voltage ProtectionRT9194 equips the V OUT under-voltage (UV) protection function. The UV protection circuits will start monitoring the power status after the PGOOD pin goes high. If the output voltage drops to below 75% of its setting value, the PGOOD and DRI pins will be pulled low and latch RT9194. The UV latch status will be released only when V CC or Enable pin goes low and returns high again, which will also cause RT9194 to re-activate.MOSFET SelectionThe RT9194 are designed to driver external N-Channel MOSFET pass element. MOSFET selection criteria include threshold voltage V GS (V TH), maximum continuous drain current ID, on-resistance R DS(ON) ,maximum drain-to-source voltage V DS and package thermal resistance θ(JA).The most critical specification is the MOSFET R DS(ON). Calculate the required R DS(ON) from the following formula:For example, the MOSFET operate up to 2A when the input voltage is 1.5V and set the output voltage is 1.2V, R ON = (1.5V-1.2V) / 2A = 150mΩ, the MOSFET's R ON have to select lower than 150mΩ. A Philip PHD3055E MOSFET with an R DS(ON) of 120mΩ(typ.) is a close match.And carry on consider the thermal resistance from junction to ambient θ(JA) of the MOSFET's package. The power dissipation calculate by :P D = (V IN − V OUT) x I LOADThe thermal resistance from junction to ambient θ(JA) calculate by :In this example, P D = (1.5V − 1.2V) x 2A = 0.6W. The PHD3055E's θ(JA) is 75°C/W for its D-PAK package, which translates to a 45°C temperature rise above ambient. The package provides exposed backsides that directly transfer heat to the PCB board.DAJ(JA)P)T(T−=θLOADOUTINDS(ON)IVVRNMOSFET−=Application InformationInformation that is provided by Richtek Technology Corporation is believed to be accurate and reliable. Richtek reserves the right to make any change in circuit design, specification or other related things if necessary without notice at any time. No third party intellectual property infringement of the applications should be guaranteed by users when integrating Richtek products into any application. No legal responsibility for any said applications is assumed by Richtek.Richtek Technology CorporationHeadquarter5F, No. 20, Taiyuen Street, Chupei City Hsinchu, Taiwan, R.O.C.Tel: (8863)5526789 Fax: (8863)5526611Richtek Technology CorporationTaipei Office (Marketing)5F, No. 95, Minchiuan Road, Hsintien City Taipei County, Taiwan, R.O.C.Tel: (8862)86672399 Fax: (8862)86672377Email:*********************Outline DimensionA1HSOT-23-6 Surface Mount Package。
Mettler Toledo IND690xx 重量表面显示器说明书
News5Industrial weighing and measuringFine ChemicalsSpeed up your filling processes also in classified areasManual or semi-automatical, filling of drums or large bags requires great precision. Standalone, or incorporated into a system, the weighing instrument has to ensure you achieve the target weight quickly and accurately.Optimize your manufacturing process in classified areas with METTLER TOLEDO’s new IND690xx weighing indicator. The versatile software options allow you to speed-up filling, batching or formulation processes, increase product quality and reduce costs generated by material waste or prolonged downtime. The IND690xx is effective to guarantee a highly accurate and reliable process: the stainless steel design makes it tough enough for any type of aggressive environment without compromising on sensitivity or speed to weigh and measure. The software pac IND690fill has many intelligent features to allow operation of a filling bay either as a standalone solution or integrated with your process control system. Connect your IND690xx to up to four scales and/or balances, and you can quickly upgradefrom manual operation to a fully auto-matic dispensing system with IND690fill. Just plug and play!Key features of the software pac IND690fill• Learn mode – upon target weight speci-fication, cut-off of each component will be determined automatically.• Safe filling through controlled valve shut-off in case of power loss.• Customized dispensing through switch-able functions such as scale change-over, residue and fill quantity control,material leveling or manual correction.M ETTLER TOLEDO Fine Chemicals News 5B a t c h i n g s o l u t i o n sIND560• Water and dust-proof• Easy to operate filling solution: the Fill-560 application software allows prompt configuration of sequences for filling, blending, dosing and dispensing• TraxDSP™ filtering system provides accurate weight measurements even in unstable environments• High reliability: calibration manage-ment monitors performance and alerts operators of maintenance needs formaximum uptimeThe IND560 process weighing instrument helps you achieve the higest product qual-ity at high speed. Embedded in the weigh-ing indicators is TraxDSP™, super-fast, multi-stage digital filtering software that provides maximum accuracy during fill-ing and mixing processes. TraxDSP™ up-dates weight signals very fast and elimi-nates noise and vibrations generated for example:• by tank’s mixing• due to the presence of nearby machinery • in unstable environmentsDue to these capabilities, all compo-nents are added accurately to the mixer as if there was no agitation or harsh environment.In your process there are numerous steps where weighing requires the most reliable and accurate technology. In your mixing processes, for example, speed and accuracy are crucial to optimize productivityand to satisfy the strict requirements of your end-users with high quality products.TraxDSP™ – supreme noise and vibration filtering• No loss of accuracy in a dynamic environment• Keeps pace with your process speed, update rate > 300Hz• Ideal for mixing, agitating or dynamic processes• Filters-out background noise and vibration• Multi-stage digital filter:– Low-pass filter (0.0-9.99Hz)– Cutoff corner frequency (0.1-99.9Hz)– Notch and stability filterPublisherMettler-Toledo AG IndustrialHeuwinkelstrasse CH-8606 Nänikon Switzerland ProductionMarCom Industrial CH-8606 Nänikon SwitzerlandSubject to technical changes © 04/ 008 Mettler-Toledo AG Printed in SwitzerlandSupreme noise and vibration controlMaximum accuracy during batching and mixing stepsM ETTLER TOLEDO Fine Chemicals News 5Connect your analog load cells over:• Profibus ® DP • Allen-Bradley RIO • RS232directly to your PLC or DCS for batch-ing, filling, tank/hopper weighing, and for inventory control without detouring data flow through any intermediate de-vice such as an indicator, local display, repeater, etc.Our smart weight transmitter is your pain-reliever. The IND130 can be placed on the weighing spot close to your tank, silo, re-actor or wherever you want to weigh. A stainless steel enclosure guarantees for smooth operation even in harsh environ ments.Key benefits• Highest yield achieved by accurate weighing of chemicals and material transfer• Fully automated and closed systems weighing of chemicals minimize cross-contamination• Reduced installation/maintenance costs • Easy calibration with CalFREE™ without test weights• Stable weight data through TraxDSP™• Digital vibration filteringIND130 quick facts • 4 x 350 Ω load cells• Stainless steel enclosure (optional)• Configuration and calibration via PC-tool • CalFREE™ calibration w/o test weights • TraxDSP™ digital vibration filtering• 1 input, 2 outputs and 1 programmable setpoint • 24VDC power supply (optional)• DIN-rail mountCalFREE™ – the easy way to a quick calibration • No need of test weights• Ideal for higher capacity thanks• Big savings due to the minute scale calibration– Enter units, scale capacity and Increment, mV/V gain – Enter load cell capacity, output and– Hit enter and you’re done!IND130PLCLoad Cells,Scale basesSmart IND130Direct to destination without detourCourtesy AltanaM ETTLER TOLEDO Fine Chemicals News 54Courtesy BASFV e h i c l e w e i g h i ngGet to know the flow of your goodsUp and running in no timeMTX POWERCELL ® brand load cells are easily exchangeable through a protected water-proof connectorDigital MTX POWERCELL ® load cells • Five years warranty• 25-90t / 55 000-200 000lbs • Instant failure notification • IP68/IP69k protection • 3000e – 6000e OIML • 5000e – 10 000e NTEP• ATEX Zone 1/21 & 2/22 and FM Divisions 1 & 2 approved • Worldwide approval• Worldwide calibration and expert service • Integral lightning protectionMETTLER TOLEDO truck and rail scales are government certified to precisely weigh to 20kg and deliver highest accuracy and reliability even under harsh weather conditions.The industry-leading MTX POWERCELL ® based scales, insure your trucks and rail cars are quickly and accurately weighed and that your scale is up and running 24/7. The only time you should see the service technician is during routine main-tenance – this translates directly into real cost savings. And, in the very rare event of a cell failure, usually due to a physi-cal damage to the cell or cable, the MTXPOWERCELL ® network instantly reports the failure as well as the failure location – and a technician is quickly onsite get-ting you back up and running.With MTX POWERCELL ® load cells, vehicle scales are successfully operating in many normal and extreme environments, includ-ing deserts, Siberia and the Antarctic.Many METTLER TOLEDO customers realize immediate and significant revenue savings by weighing vehicles and by filling or discharging on a weighbridge.Connect your scale to OverDrive™vehicle management software The powerful OverDrive™ vehicle scale software is designed to fully control inbound/outbound transactions of your production/storage facility. It enables you to determine what data is important, allows you to customize the user interface, tickets and reports, and provides import/Highlights of the OverDrive™basic software package• Database tables for Account, Carrier, Company, Container, Contract, Driver, Permit, Product, Remark 1, Remark 2, Surcharge, Tax, Trailer, Vehicle, and 25 additional tables• Multi-axle and split weighing• Security setup for assigning access rights to users• Transaction maintenance• Weights and measures log• Standard reports and tickets• Wizards for data conversion, database import/export, alarms, and pricing Highlights of the OverDrive™advanced transaction module • Capability to customize reports and tick-ets (Crystal Reports 9.0 required)• Synchronization module for network installations synchronizes master data-base on a server to databases on indi-vidual PCs• Oracle support module can use Oracle®8i database• Unattended module enables unat-tended weighing with transaction wizard, touch screen• Internet package module processes remote transactions via the Internet • Additional scale module enables softwareto control as many as six scales1export capabilities for use with your CRM/MES/ERP system. OverDrive software canconnect to as many as six scale indicatorsand to peripheral devices such as trafficlights, gates, card readers, and unattendedweighing stations.456M ETTLER TOLEDO Fine Chemicals News 55M ETTLER TOLEDO Fine Chemicals News 56I n -l i n e c o n t r o l s o l u t i o n sConductivity measurement for high process securityIn-line conductivity measurement technology plays an essential role in the efficient operation of Cleaning-In-Place systems, ensuring the high-est possible levels of cleanliness as well as optimal control over the cleaning solutions.Cleaning-in-Place (CIP)e quipment, a part of the production systemCIP systems are an integral part of produc-tion systems in the API & Fine Chemicals Industry. Cleaning is carried out in compliance with clearly defined official regulations. At the end of each cleaning cycle, the cleaning solutions involved are returned to storage tanks for later reuse. Controlled recovery of the acid and alka-line solutions enables to determine their degree of reusability.Control of acids and alkalines via conductivity measurementThe level of concentration of the recovered acids and alkalines is established through conductivity measurement. In order to ensure the correct concentration in the individual tanks, the recovered solutions are automatically re-concentrated to the required strength.Cleaning procedureControl of various CIP process stages such as start of dosing of alkaline or acid, or rinsing with water, is carried out efficiently and cost-effectively via in-line measure-ment of conductivity. Conductivity meas-urement allows to establish the degree of contamination of the cleaning solutions in the return pipe and thereby also allows to determine whether the solutions can be recycled or should be rejected.requirements on hygiene and designed to suppress the growth of unwanted bac-teria. Process safety and minimization of production losses and laboratory costs clearly take first priority. The precision of the in-line conductivity measurement for quality control of the different solutions before and after the cleaning process, and assessment of the degree of reusability of the cleaning solutions, combine to under-line the advantages of in-line conductivity measurement in CIP plant in the strictly regulated industry.InPro 7108: User benefits No dead pockets Designed for hygiene requirements Guards against bacterial growth No contamination of wetted parts Minimized production losses Short process cycle time /condInPro 7108.The CIP cleaning procedure is a multi step process. In a first step, the different wash solutions are prepared in storage tanks with the assistance of conductivity measurement. Final rinse with ultrapure water takes place at the end of the proce-dure. Conductivity measurement value of the ultrapure water determines the end of the CIP cycle.Conductivity controls CIP process Conductivity measurements allow to dis-tinguish between the separate cleaning agents, the product, and the rinse water. Contamination can be successfully detect-ed and the concentration of each washsolution can be established very accu-rately. The cleaning program is simpleto control via the limit switch contactsof the transmitter, and easy to integrateinto a Process Control System (PCS). Theconductivity sensors used to monitor the dosing apparatus are built directly into thesolution tanks, so that if a concentration falls below a set value, the appropriate preprogrammed transmitter limit contact is activated and the acid or alkaline feed pump switches on accordingly.InPro 7108-VAR-VP, widely used in the regulated industryEstablishing the contamination level of the CIP cleaning solutions via conductiv-ity measurement greatly contributes to quality control before and after the clean-ing cycle. The InPro 7108-VAR-VP is opti-mally suited for applications with highM ETTLER TOLEDO Fine Chemicals News 57/turbControl of turbidityoptimizes crystallization processIn-line turbidity measurements provide early indication of quality deviation in the precipitation reaction of the crystallization process. It saves time and costs in downstream processing.BackgroundAn amine (R-NH 2) produced by synthesis in the API industry exists in the form of a hydrochloride salt ([R-NH 3]+ Cl -) and is precipitated from a clear solution through the addition of caustic soda (NaOH). Samples of the precipitated amine revealed strong and unacceptable fluctuations in product purity.Clear turbidity signal of crystalli-zation is requiredPrecipitation conditions, solvent composi-tion, concentration and dosage rate of the caustic soda all have an influence on the quality of the intermediate product. The use of an in-line turbidity measure-ment system has provided important infor-mation contributing to optimization of this reaction step. The figure graphically illustrates the gradient of the signals of the turbidity sensor in relation to the dosing rate(s) of caustic soda. A linear increase in the dosing rates was accompanied by an increase in the level of turbidity, followedby signal decay before the concentration of solid particles slowly evened out to a stable value. The decay of the turbidity signal points to conglomeration of the finer crystals, pos-sibly also includes entrapped impurities. A more rapid, optimized dosing of caustic soda leads to spontaneous precipitation of the whole product which, furthermore, also displays a higher degree of purity.The goal: time saving and avoidance of faulty charges Detailed understanding of the optimum precipitation conditions therefore results in being able to achieve a product with the required degree of purity. The use of an in-line turbidity sensor in the process pro-vides information on how these condi-tions are to be maintained and therefore gives early indication of any quality de-viation in the precipitation reaction. This successfully prevents time-consumingand costly downstream processing of faulty charges.Reliable measurement with METTLER TOLEDO solution The turbidity sensor InPro 8200 has beenproven to be the ideal solution for this typeof application. The use of scratchproof sapphire windows allows long-term opera-tion even in the presence of abrasive crys-tals. Signal transmission between sensor and transmitter employing optical fiber cable technology in conjunction with the principle of backscattered light results ina sensor with a compact design of whichinstallation is equally possible in small research reactors and in large production-scale vessels.Features of the InPro 8200Ideal for medium to low concentration and where high resolution is required. Two optical fibresSmooth sensor design prevents fouling and reduces maintenance Wide measuring range High accuracySapphire window for fiber protectionInPro 8 00.Gradients of the turbidity signal.Rapid dosing Ethanol addition/fine-chemicalsFor more informationMettler-Toledo AG CH-8606 Greifensee SwitzerlandTel. + 41 44 944 22 11Fax + 41 44 944 30 60Your METTLER TOLEDO contact:ErgoSensIndividually configurable sensor – for hands-free operation of the XPIn the API & Fine Chemicals Industry, accurate and efficient sampling is key for higher yields. Samples of powders and liquids are weighed on a daily basis for quality control.The XP analytical balance with the two revolutionary optical sensors “SmartSens”, offers a secure way to weigh even while wearing gloves!With either “SmartSens” or the freely placeble “ErgoSens”, you can carry out up to four weighing operations without touching the balance at all!Hand-free technology for trouble-free weighingWeighing of harmful or toxic substances for quality control purposes is part of your daily business and requires strict procedures to avoid contact and contamination.Key benefits• Efficient and accurate sampling• Highest safety in handling toxic sub-stances• Minimized balance contamination • Up to four hands-free operations can be programmed, i.e. zeroing, taring, opening & closing doors, printoutdisplay, or a PC.。
Primacord产品说明书
1. IDENTIFICATION OF THE MATERIAL AND SUPPLIERPRIMACORD ● PRIMACORD 4 DETONATING CORD ● PRIMACORD DETONATING CORD ● PRIMALINE ● PRIMALINE 10 DETONATING CORD ● PRIMCORD 5 DETONATING CORD ● SPECIAL 18 DETONATING CORD ● SPECIAL 18AA DETONATING CORD ● SPECIAL 18T DETONATING CORD ● SPECIAL 25DETONATING CORD ● SPECIAL 25A DETONATING CORD ● SPECIAL 25AA DETONATING CORD ●SPECIAL 25T DETONATING CORD ● SPECIAL 50 DETONATING CORD ● SPECIAL 50AA DETONATING CORD ● SPECIAL 50T DETONATING CORDSynonymsDETONATING CORD Uses1.2 Uses and uses advised against1.3 Details of the supplier of the productDYNO NOBEL ASIA PACIFIC LIMITED Supplier name 282 Paringa Rd, Gibson Island, Murarrie, QLD, 4172, AUSTRALIA Address (07) 3026 3900Telephone (07) 3026 3999Fax 1800 098 836Emergency1.4 Emergency telephone numbers Website1.1 Product identifier DETONATING CORDProduct name 2. HAZARDS IDENTIFICATIONCLASSIFIED AS HAZARDOUS ACCORDING TO SAFE WORK AUSTRALIA CRITERIA 2.2 GHS Label elements Signal word DANGERExplosive; mass explosion hazard.H201Hazard statementsPictogramsPhysical HazardsExplosives: Division 1.1Health HazardsNot classified as a Health HazardEnvironmental HazardsNot classified as an Environmental Hazard 2.1 Classification of the substance or mixtureNo information provided.2.3 Other hazardsRefer to manufacturer/supplier for information on disposal/recovery/recycling.P503Disposal statements Store in accordance with relevant site and storage provisions.P401Storage statements In case of fire: Explosion risk. Evacuate area. DO NOT fight fire when fire reaches explosives.P370 + P372 + P380 + P3Response statements Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.P210Keep wetted.P230Keep only in original packaging.P234Ground and bond container and receiving equipment.P240Do not subject to grinding/shock/friction/rough handling.P250Wear protective gloves/protective clothing/eye protection/face protection/hearing protection.P280Prevention statements 3. COMPOSITION/ INFORMATION ON INGREDIENTSIngredientCAS Number EC Number Content >60%78-11-5201-084-3PENTAERYTHRITOL TETRANITRATE (PETN)RemainderNot AvailableNot AvailableNON HAZARDOUS INGREDIENTS3.1 Substances / Mixtures4. FIRST AID MEASURESIf in eyes,hold eyelids apart and flush continuously with running water.Continue flushing until advised to stop by a Poisons Information Centre, a doctor, or for at least 15 minutes.4.1 Description of first aid measuresEyeIf inhaled, remove from contaminated area. Apply artificial respiration if not breathing.Inhalation If skin or hair contact occurs,remove contaminated clothing and flush skin and hair with running water.Continue flushing with water until advised to stop by a Poisons Information Centre or a doctor.Skin For advice,contact a Poisons Information Centre on 131126(Australia Wide)or a doctor (at once).If swallowed, do not induce vomiting.Ingestion Eye wash facilities and normal washroom facilities should be available.First aid facilitiesSee Section 11 for more detailed information on health effects and symptoms.4.2 Most important symptoms and effects, both acute and delayed4.3 Immediate medical attention and special treatment needed Treat symptomatically.5. FIRE FIGHTING MEASURESEXPLOSIVE.Will explode under specific conditions.May evolve toxic gases (carbon/nitrogen oxides,hydrocarbons)when heated to decomposition.Eliminate all ignition sources including cigarettes,open flames,spark producing switches/tools,heaters,naked lights,pilot lights, etc when handling. CAUTION: Will explode if exposed to heat or with heavy impact.5.2 Special hazards arising from the substance or mixtureEvacuate area and contact emergency services.Toxic gases may be evolved in a fire situation.Remain upwind and notify those downwind of hazard.Do not attempt to fight e waterfog to cool intact containers and nearby storage areas.May explode from heat, pressure, friction or shock.5.3 Advice for firefightersEEvacuation of people in and around the immediate vicinity of the incident should be considered.5.4 Hazchem code DO NOT attempt to extinguish burning explosives. Evacuate area immediately. Notify trained emergency response personnel.5.1 Extinguishing media6. ACCIDENTAL RELEASE MEASURESClear area of all unprotected personnel.Contact emergency services where appropriate.CAUTION:Heating,impact or static charge may cause explosion.6.1 Personal precautions, protective equipment and emergency proceduresPrevent product from entering drains and waterways.6.2 Environmental precautionsHANDLE WITH CARE:Spilled explosive powder is extremely sensitive to initiation and may detonate.If cords or containers are damaged, contain spillage, then collect and place in suitable containers for disposal. Eliminate all sources of ignition.6.3 Methods of cleaning upSee Sections 8 and 13 for exposure controls and disposal.6.4 Reference to other sections7. HANDLING AND STORAGEStore in clean,dry magazine licensed for Explosives.Separate magazines are required for cords and explosives.Store removed from incompatible substances,mechanical shock,heat or ignition sources.Ensure cords are adequately labelled and protected from physical damage. Large storage areas should have appropriate ventilation and fire protection systems.7.2 Conditions for safe storage, including any incompatibilitiesNo information provided.7.3 Specific end uses 7.1 Precautions for safe handlingBefore use carefully read the product e of safe work practices are recommended to avoid eye or skin contact and inhalation.Observe good personal hygiene,including washing hands before eating.Prohibit eating,drinking and smoking in contaminated areas.Take precautionary measures against electrostatic discharges.8. EXPOSURE CONTROLS / PERSONAL PROTECTION8.1 Control parameters Exposure standardsNo exposure standards have been entered for this product.Biological limits IngredientDeterminantBEISampling Time1.5% of hemoglobinDuring or end ofshiftMethemoglobin in bloodPENTAERYTHRITOL TETRANITRATE (PETN)Reference: ACGIH Biological Exposure IndicesPPEEye / Face Wear dust-proof goggles.Hands Wear PVC or rubber gloves.Body Wear coveralls.RespiratoryNot required under normal conditions of use.Avoid e in well ventilated areas.Where an inhalation risk exists,mechanical explosion proofextraction ventilation is recommended.8.2 Exposure controlsEngineering controls 9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesCORD WITH WHITE POWDER CORE AppearanceODOURLESS OdourEXPLOSIVE FlammabilityNOT RELEVANT Flash pointNOT AVAILABLE Boiling point140°C (PETN)Melting pointNOT AVAILABLE Evaporation rateNOT AVAILABLE pHNOT AVAILABLE Vapour density1.76Relative densityINSOLUBLE Solubility (water)NOT AVAILABLE Vapour pressureNOT RELEVANT Upper explosion limitNOT RELEVANT Lower explosion limitNOT AVAILABLE Partition coefficientNOT AVAILABLE Autoignition temperatureNOT AVAILABLEDecomposition temperature NOT AVAILABLE ViscosityEXPLOSIVE Explosive propertiesNOT AVAILABLE Oxidising propertiesNOT AVAILABLE Odour threshold10. STABILITY AND REACTIVITY10.2 Chemical stabilityExplosive material. Detonation may occur from impact, friction, or excessive heating.10.4 Conditions to avoidAvoid shock, friction, heavy impact, heat, sparks, open flames and other ignition sources.10.5 Incompatible materialsIncompatible with oxidising agents (e.g.hypochlorites),combustible materials,acids (e.g.nitric acid),mechanical shock and heat or ignition sources.May evolve toxic gases (carbon/ nitrogen oxides, hydrocarbons) when heated to decomposition.10.6 Hazardous decomposition productsPolymerization will not occur.10.3 Possibility of hazardous reactions 10.1 ReactivityCarefully review all information provided in sections 10.2 to 10.6.11. TOXICOLOGICAL INFORMATIONDue to the product encapsulation,acute toxicity associated with the contents is not anticipated with normal e safe work practices to avoid dust/fume inhalation after detonation.WARNING:May explode with shock, heat, friction or static charge. Serious damage may result from explosive fragments.Acute toxicityInformation available for the ingredients:IngredientOral LD50Dermal LD50Inhalation LC501660 mg/kg (rat)----PENTAERYTHRITOL TETRANITRATE (PETN)Not classified as a skin irritant.Due to product form,exposure can only occur during detonation.Serious damage may result from explosive fragments.Skin Not classified as an eye irritant.Due to product form,exposure can only occur during detonation.Serious damage may result from explosive fragments.EyeNot classified as causing skin or respiratory sensitisation.Sensitisation Not classified as a carcinogen.CarcinogenicityNot classified as a mutagen.Mutagenicity 11.1 Information on toxicological effectsNot classified as causing organ damage from single exposure.However,serious damage may result from explosive fragments.STOT - single exposure Not classified as causing aspiration.AspirationNot classified as causing organ damage from repeated exposure.STOT - repeated exposure Not classified as a reproductive toxin.Reproductive 12. ECOLOGICAL INFORMATION12.1 ToxicityNo information provided.12.2 Persistence and degradability No information provided.12.4 Mobility in soil No information provided.No information provided.12.5 Other adverse effects 12.3 Bioaccumulative potential No information provided.13. DISPOSAL CONSIDERATIONSReturn to manufacturer/supplier or dispose of in accordance with State and Federal legislative requirements for Explosives. Contact the manufacturer/supplier for additional information (if required).13.1 Waste treatment methodsWaste disposalDispose of in accordance with relevant local legislation.Legislation14. TRANSPORT INFORMATIONLAND TRANSPORT (ADG)SEA TRANSPORT (IMDG / IMO)AIR TRANSPORT (IATA / ICAO)None allocated.1.1D 1.1D None allocated.None allocated.None allocated.14.3 Transport hazard class 14.4 Packing Group CORD, DETONATING, flexible0065CORD, DETONATING, flexible0065PROHAir transport PROHIBITED under the International Air Transport Association (IATA) Dangerous Goods Regulations for transport by air in passenger and cargo aircraft.14.1 UN Number 14.2 Proper Shipping NameNot a Marine Pollutant.14.5 Environmental hazards E Hazchem code F-B, S-XEmSEXP1GTEPG 14.6 Special precautions for userCLASSIFIED AS A DANGEROUS GOOD BY THE CRITERIA OF THE ADG CODE15. REGULATORY INFORMATIONA poison schedule number has not been allocated to this product using the criteria in the Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP).15.1 Safety, health and environmental regulations/legislation specific for the substance or mixturePoison scheduleAUSTRALIA: AIIC (Australian Inventory of Industrial Chemicals)All components are listed on AIIC, or are exempt.Inventory listingsSafe Work Australia criteria is based on the Globally Harmonised System (GHS)of Classification and Labelling of Chemicals (GHS Revision 7).Classifications 16. OTHER INFORMATIONDISCLAIMER:The information provided herein concern explosive products which should only be handled by persons having the appropriate technical expertise,training,and licence(s).The result is largely dependent upon the conditions of storage, transportation and use.Whilst Dyno Nobel Asia Pacific make every effort to ensure the information contained within this SDS is as accurate and up-to-date as possible,the conditions under which its products are used are not within Dyno Nobel Asia Pacific's control.Each user has the responsibility to ensure awareness of the details contained within this SDS,the product applications,and the specific context of the intended usage.Buyers and users assume all risk,responsibility and liability arising from the use of this product and the information within this SDS.Dyno Nobel Asia Pacific is not responsible for damages of any nature resulting from the use of its products or reliance upon the information.Dyno Nobel Asia Pacific makes no express or implied warranties other than those implied mandatory by the Commonwealth, State or Territory Legislation.EXPLOSIVES &BLASTING AGENTS:Refer to Local State and Federal legislation that specifically relates to the use of ers of products described in this ChemAlert Report are advised to ensure familiarity and compliance with the appropriate legal requirements (e.g.Regulations)prior to the use of this product.Where any further information is required,users may contact their local authority in Explosives and Dangerous Goods.EXPLOSIONS:Fires involving explosives or explosive mixtures may undergo further explosions and rapid propagation.Police and emergency personnel should be notified immediately.Evacuate individuals to a safe sheltered area at least 800metres away.If possible remove vehicles and further heat and ignition sources from the area.Do not return to areas until at least one hour after fire and explosions have ceased.EXPLOSIONS:For further information please refer to Australian Standard 1216,for classification of explosives and Local and Federal Explosive and Dangerous Goods legislation (Act and Regulations).EXPLOSIVES - BURNING SAFETY:Note: Disposal in a blast with fresh explosives may be preferable to burning.PERSONAL PROTECTIVE EQUIPMENT GUIDELINES:The recommendation for protective equipment contained within this report is provided as a guide only.Factors such as form of product,method of application,working environment,quantity used,product concentration and the availability of engineering controls should be considered before final selection of personal protective equipment is made.HEALTH EFFECTS FROM EXPOSURE:It should be noted that the effects from exposure to this product will depend on several factors including:form of product;frequency and duration of use;quantity used;effectiveness of control measures;protective equipment used and method of application.Given that it is impractical to prepare a report which would encompass all possible scenarios,it is anticipated that users will assess the risks and apply control methods where appropriate.Additional informationACGIH American Conference of Governmental Industrial HygienistsAbbreviationsCAS #Chemical Abstract Service number - used to uniquely identify chemical compoundsCNS Central Nervous SystemEC No.EC No - European Community NumberEMS Emergency Schedules (Emergency Procedures for Ships Carrying DangerousGoods)GHS Globally Harmonized SystemGTEPG Group Text Emergency Procedure GuideIARC International Agency for Research on CancerLC50Lethal Concentration, 50% / Median Lethal ConcentrationLD50Lethal Dose, 50% / Median Lethal Dosemg/m³Milligrams per Cubic MetreOEL Occupational Exposure LimitpH relates to hydrogen ion concentration using a scale of 0 (high acidic) to 14 (highlyalkaline).ppm Parts Per MillionSTEL Short-Term Exposure LimitSTOT-RE Specific target organ toxicity (repeated exposure)STOT-SE Specific target organ toxicity (single exposure)SUSMP Standard for the Uniform Scheduling of Medicines and PoisonsSWA Safe Work AustraliaTLV Threshold Limit ValueTWA Time Weighted AverageThis document has been compiled by RMT on behalf of the manufacturer,importer or supplier of the Report statusproduct and serves as their Safety Data Sheet ('SDS').It is based on information concerning the product which has been provided to RMT by themanufacturer,importer or supplier or obtained from third party sources and is believed to representthe current state of knowledge as to the appropriate safety and handling precautions for the productat the time of issue.Further clarification regarding any aspect of the product should be obtaineddirectly from the manufacturer, importer or supplier.While RMT has taken all due care to include accurate and up-to-date information in this SDS,it doesnot provide any warranty as to accuracy or completeness.As far as lawfully possible,RMT acceptsno liability for any loss,injury or damage(including consequential loss)which may be suffered orincurred by any person as a consequence of their reliance on the information contained in this SDS.Risk Management TechnologiesPrepared by5 Ventnor Ave, West PerthWestern Australia 6005Phone: +61 8 9322 1711Fax: +61 8 9322 1794Email:************.auWeb: [ End of SDS ]。
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捷诺达说明书导读：我根据大家的需要整理了一份关于《捷诺达说明书》的内容，具体内容：捷诺达配合饮食和运动治疗，用于经二甲双胍单药治疗血糖仍控制不佳或正在接受二者联合治疗的2型糖尿病患者。
下面是我整理的，欢迎阅读。
捷诺达商品介绍捷诺达通用名：西格...捷诺达配合饮食和运动治疗，用于经二甲双胍单药治疗血糖仍控制不佳或正在接受二者联合治疗的2型糖尿病患者。
下面是我整理的，欢迎阅读。
捷诺达商品介绍捷诺达通用名：西格列汀二甲双胍片(I)生产厂家: 波多黎各Patheon Puerto Rico Inc.批准文号：注册证号H20140774药品规格：50mg:500mg*28片【药品名】捷诺达西格列汀二甲双胍片(I)【通用名】西格列汀二甲双胍片(I)【英文名】SitagliptinPhosphate/metforminHydrochlorideTablets 【汉语拼音】JieNuoDaXiGeLieTingErJiaShuangGuaPian【主要成分】捷诺达为复方制剂，其组份为磷酸西格列汀和盐酸二甲双胍。
磷酸西格列汀化学名称：7-[(3R)-3-氨基-1-氧-4-(2,4,5-三氟苯基)丁基]-5,6,7,8-四氢-3-(三氟甲基)-1,2,4-三唑酮[4,3-a]吡嗪磷酸盐(1:1)一水合物，分子式：C16H15F6N5OH3PO4H2O，分子量：523.32。
盐酸二甲双胍化学名称：1,1-二甲基双胍盐酸盐，分子式：C4H11N5HCl，分子量：165.63。
【性状】为粉红色异形薄膜衣片，除去包衣后显白色。
【适应症】配合饮食和运动治疗，用于经二甲双胍单药治疗血糖仍控制不佳或正在接受二者联合治疗的2型糖尿病患者。
【用法用量】一般建议：用捷诺达进行降糖治疗时，应根据患者目前的治疗方案、治疗的有效程度、对药物的耐受程度给予个体化的剂量，但不能超过磷酸西格列汀100mg和二甲双胍2000mg的每日大推荐剂量。
通常的给药方法是每日2次，餐中服药，并且在增加药物剂量时应当逐渐增量以减少二甲双胍相关的胃肠道副作用。
根据患者目前的治疗方案来决定捷诺达的初始剂量。
每日服药2次，餐中服药。
对于单独服用二甲双胍血糖控制不佳的患者，捷诺达的初始剂量应当提供西格列汀的剂量为50mg每日2次(每日总剂量100mg)再加上目前正在服用的二甲双胍的剂量。
对于正同时接受西格列汀和二甲双胍治疗，现需要更换治疗方案的患者，捷诺达的初始剂量可根据患者目前正在服用的西格列汀和二甲双胍的剂量选择。
【禁忌】磷酸西格列汀/盐酸二甲双胍的禁忌包括：-肾病或肾功能异常，即血清肌酐水平1.5mg/dL(男性)、1.4mg/dL(女性)，或肌酐清除率异常，这些情况也有可能是由循环衰竭(休克)、急性心肌梗死和败血症引起。
-已知对磷酸西格列汀、盐酸二甲双胍或捷诺达的任何其它成分过敏。
-急性或慢性代谢性酸中毒，包括糖尿病酮症酸中毒在内，无论是否伴有昏迷。
对于接受影像学检查需要血管内注射含碘造影剂的患者，应暂时停止捷诺达治疗，因为这类造影剂可能造成急性肾功能改变。
【注意事项】乳酸性酸中毒：-乳酸性酸中毒是一种罕见但严重的并发症，可以在捷诺达治疗过程中由于二甲双胍的蓄积而发生。
在败血症、脱水、过度饮酒、肝功能受损、肾功能不全和急性充血性心力衰竭等情况下，发生风险增加。
-发作时仅伴有非特异性症状，包括全身不适、肌痛、呼吸困难、嗜睡加重和非特异性腹部不适。
实验室检查异常包括pH值下降、阴离子间隙增高和血乳酸水平升高。
-一旦怀疑酸中毒，应让患者立即停用捷诺达并住院治疗。
【不良反应】西格列汀二甲双胍复方制剂中各活性成分的不良反应：西格列汀已知不良反应：在西格列汀单药治疗的患者中发生率5%且比接受安慰剂患者更常见的不良事件(不考虑研究者对因果关系的评估)是鼻咽炎。
二甲双胍的已知不良反应：开始二甲双胍治疗后常见(>5%)的已确定不良反应是腹泻、恶心/呕吐、胃肠胀气、腹部不适、消化不良、衰弱和头痛。
其他少见者为大便异常、低血糖、肌痛、头晕、指甲异常、皮疹、出汗增加、味觉异常、胸部不适、寒战、流感样症状、潮热、心悸、体重减轻等。
二甲双胍可减少维生素B12吸收，但极少引起贫血。
捷诺达在治疗剂量范围内，引起乳酸性酸中毒罕见。
上市后经验：在捷诺达或其成分之一西格列汀上市使用后，有如下其他的不良反应报告。
这些不良反应可见于捷诺达或西格列汀单药治疗和/或与其它降血糖药联合治疗。
由于这些反应由不确定数量的人群自发报告，通常不可能可靠地估计其发生频率或与药物暴露量建立因果关系。
过敏反应，包括过敏症、血管性水肿、疹、风疹、皮肤血管炎和剥脱性皮肤损害，包括Stevens-Johnson综合征;急性胰腺炎，包括致死性和非致死性出血性和坏死性胰腺炎;肾功能恶化，包括急性肾功能衰竭(有时候需要透析);上呼吸道感染;肝酶水平升高;便秘;呕吐;头痛;关节痛;肌痛;肢体疼痛;背痛。
实验室检查：磷酸西格列汀：在接受西格列汀和二甲双胍治疗的患者中实验室不良反应的发生率(7.6%)与接受安慰剂和二甲双胍治疗的患者(8.7%)相似。
在大多数但不是所有研究中，由于嗜中性粒细胞小幅度增加，观察到白细胞计数出现小幅度增加(相对于安慰剂，白细胞的差异大约为200细胞/uL;白细胞的基线平均值大约为6600细胞/uL)。
实验室参数的变化被视为没有临床意义。
盐酸二甲双胍：在二甲双胍的一项为期29周的对照试验中，在大约7%的患者中观察到既往正常的维生素B12血清浓度降低到正常水平以下，但没有临床表现。
这种维生素B12水平的下降可能是由于二甲双胍干扰了B12-内因子复合物吸收B12所致，然而，该现象伴有贫血非常罕见。
停用二甲双胍或补充维生素B12后很快缓解。
【药物相互作用】磷酸西格列汀：研究药物相互作用的试验表明，西格列汀对以下药物的药代动力学不会产生临床意义的影响：二甲双胍、罗格列酮、格列本脲、辛伐他汀、华法令以及口服避孕药。
这些资料说明西格列汀不会抑制CYP辅酶CYP3A4、2C8或2C9。
体内试验的结果也表明，西格列汀不会抑制CYP辅酶CYP2D6、1A2、2C19或2B6，也不会诱导产生CYP3A4。
已经有研究对2型糖尿病患者的人群药代动力学特点进行了分析。
结果发现这些患者服用的其他药物对西格列汀的药代动力学没有产生有临床意义的影响。
这些药物主要是指2型糖尿病患者经常服用的药物，包括降胆固醇药物(如他汀类、贝特类、依折麦布)、抗血小板药物(如氯吡格雷)、降压药(如血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂、-受体阻滞剂、钙离子通道阻滞剂、氢氯噻嗪)、镇痛和非甾体抗炎药(如萘普生、双氯芬酸、塞来考昔)、抗抑郁药(如丁氨苯丙酮、氟西汀、舍曲林)、抗组胺药(如西替利嗪)、质子泵抑制剂(如奥美拉唑、兰索拉唑)以及治疗勃起功能障碍的药物(如西地那非)。
当地高辛与西格列汀合用时，西格列汀药代动力学曲线下面积和平均峰药浓度都有轻度增加。
目前认为这种增加程度没有临床意义。
尽管如此，对于接受地高辛治疗的患者仍应适当监测。
当患者同时服用100mg西格列汀和600mg环孢霉素时，西格列汀药代动力学曲线的AUC和Cmax分别增加了29%和68%左右。
但上述西格列汀的药代动力学变化被认为不具有临床意义。
盐酸二甲双胍：格列本脲：一项以2型糖尿病患者为研究对象的试验研究了单次给药药物之间的相互作用。
结果表明，二甲双胍和格列本脲联合治疗不会对二甲双胍的药代动力学或药效学造成任何影响。
研究中还可以观察到格列本脲药代动力学曲线的AUC减少、Cmax降低，但没有固定的趋势。
由于是单次给药药物试验，且格列本脲的血药浓度与其药效学之间没有相关性，因此观察到的这种药物相互作用的临床意义不大。
呋塞米：一项以健康受试者为研究对象的临床试验研究了单次给药二甲双胍和呋塞米之间的相互作用。
研究结果表明，联合治疗对两种药物各自的药效学参数都有影响。
呋塞米使得二甲双胍的血Cmax值增加了22%，ACU值增加了15%，但肾脏清除率没有明显变化。
而二甲双胍使呋塞米的Cmax值比单独用药时降低了31%，AUC值减少了12%，药物的终末半衰期减少了32%，但肾脏清除率没有明显变化。
没有文献记录有关二甲双胍和呋塞米长期共同用药时二者之间的相互作用。
硝苯地平：一项以健康受试者为研究对象的临床试验研究了单次给药二甲双胍和硝苯地平之间的相互作用。
研究结果表明，与硝苯地平合用可以使二甲双胍的Cmax值升高20%，AUC升高9%，并增加尿液中二甲双胍的排泄量。
二甲双胍的Tmax和半衰期不受影响。
硝苯地平似乎还可以增加二甲双胍的吸收。
二甲双胍对硝苯地平的影响很小。
阳离子药物：通过肾小管分泌系统清除的阳离子药物(如阿米洛利、地高辛、吗啡、普鲁卡因酰胺、奎尼丁、奎宁、雷尼替丁、氨苯蝶啶、甲氧苄氨嘧啶、万古霉素)，在理论上应当与二甲双胍存在相互作用，因为二者需要竞争共同的肾小管转运系统。
有试验以健康受试者为研究对象研究了单次给药和多次给药的二甲双胍与西咪替丁的药物相互作用。
结果发现二甲双胍和口服西咪替丁存在上述药物相互作用。
这两种药物联合治疗时，二甲双胍的血浆和全血的药物浓度的峰值升高了60%，血浆和全血的AUC 值升高了40%。
单次给药药物研究中没有观察到二甲双胍的清除半衰期有任何变化。
尽管上述阳离子药物与捷诺达的相互作用还停留在理论水平(除了西咪替丁以外)，但如果患者正在服用经近端肾小管分泌系统清除的阳离子药物，则建议医生应当仔细监测这类患者临床状况的变化，并相应调整捷诺达和/或伴随药物的剂量。
其他药物：有些药物容易引起高血糖，从而导致患者的血糖控制不佳。
这类药物包括噻嗪类及其他利尿药、皮质类固醇、吩噻嗪、甲状腺药物、雌激素、口服避孕药、苯妥英类、烟酸、拟交感神经药物、钙离子通道阻滞剂以及异烟肼。
如果接受捷诺达治疗的患者还服用了上述药物，则医生应当密切监测患者的血糖，保证血糖控制良好。
在健康受试者中开展的试验表明，单次给药时二甲双胍与普萘洛尔以及二甲双胍和布洛芬之间不会相互影响各自的药代动力学。
磺酰脲类药物可以与血清蛋白广泛结合，与之不同的是二甲双胍几乎不与血浆蛋白结合，因此蛋白结合力高的药物与二甲双胍之间的发生相互作用的可能性较小，这类药物包括水杨酸盐、氨磺酰、氯乙酸和丙磺舒。
【贮藏】密封，置阴凉处。
【有效期】24个月。
【生产企业】新加坡 MSD Pharma (Singapore) Pte. Ltd捷诺达的功效与作用捷诺达配合饮食和运动治疗，用于经二甲双胍单药治疗血糖仍控制不佳或正在接受二者联合治疗的2型糖尿病患者。
捷诺达服用常见问题问：捷诺达可以降低胰腺-细胞分泌的胰高糖素。
胰高血糖素浓度的降低和胰岛素水平的升高，可以减少肝脏葡萄糖的产生，导致血糖水平的下降。