Dexibuprofen右布洛芬胶囊说明书
芬必得布洛芬缓释胶囊说明书
芬必得布洛芬缓释胶囊说明书
一、药品名称
芬必得布洛芬缓释胶囊
二、成分
每颗胶囊含有布洛芬XXXmg
三、适应症
芬必得布洛芬缓释胶囊适用于缓解轻度到中度疼痛，如头痛、牙痛、肌肉痛、背痛、月经痛等症状。
四、用法和用量
口服，成人一次1-2颗，每日3次，饭后服用。
五、禁忌症
1.对芬必得布洛芬缓释胶囊中的任何成分过敏者禁用；
2.患有溃疡性结肠炎、消化性溃疡等胃肠道疾病者禁用；
3.孕妇和哺乳期妇女禁用；
4.存在血液充盈不足、心功能不全等情况者禁用。
六、注意事项
1.本品只适用于缓解轻度到中度疼痛，长期或大剂量使用可能导致胃肠道不良反应，如溃疡、出血等；
2.注意不要超过建议的用量和使用时间；
3.如果疼痛症状加重或持续超过3天，请咨询医生；
4.请勿与其他布洛芬类药物合用。
七、不良反应
1.可能引起消化道不适，如胃痛、恶心、呕吐；
2.个别病例可发生皮疹、荨麻疹、头晕、头痛等；
3.长期使用可导致贫血等。
八、药物相互作用
1.与其他药物合用可能发生相互作用，如维生素C、洋地黄、利尿剂等；
2.请在使用本品前告知医生所用的其他药物。
九、贮藏
1.存放在阴凉干燥处，避免光照；
2.避免儿童接触。
十、包装规格
每瓶装XXX颗。
十一、生产企业
XXX制药有限公司
十二、有效期
2年
以上为芬必得布洛芬缓释胶囊的说明书，如果有任何疑问，建议咨询医生或药师。
联邦缓士芬布洛芬缓释胶囊使用说明
联邦缓士芬布洛芬缓释胶囊【用法用量】口服。
成人，一次1粒，一日2次（早晚各一次）。
【注意事项】1.本品为对症治疗药，不宜长期或大量使用，用于止痛不得超过5天，用于解热不得超过3天，如症状不缓解，请咨询医师或药师。
2.必须整粒吞服，不得打开或溶解后服用。
3.不能同时服用其他含有解热镇痛药的药品（如某些复方抗感冒药）。
4.服用本品期间不得饮酒或含有酒精的饮料。
5.有下列情况患者慎用：60岁以上、支气管哮喘、肝肾功能不全、凝血机制或血小板功能障碍（如血友病）。
6.下列情况患者应在医师指导下使用：有消化性溃疡史、胃肠道出血、心功能不全、高血压。
7.如服用过量或出现严重不良反应，应立即就医。
8.对本品过敏者禁用，过敏体质者慎用。
9.本品性状发生改变时禁止使用。
10.请将本品放在儿童不能接触的地方。
11.如正在使用其他药品，使用本品前请咨询医师或药师。
【不良反应】1.少数病人可出现恶心、呕吐、胃烧灼感或轻度消化不良、胃肠道溃疡及出血、转氨酶升高、头痛、头晕、耳鸣、视力模糊、精神紧张、嗜睡、下肢水肿或体重骤增。
2.罕见皮疹、过敏性肾炎、膀胱炎、肾病综合征、肾乳头坏死或肾功能衰竭、支气管痉挛。
【禁忌】1.对其他非甾体抗炎药过敏者禁用。
2.孕妇及哺乳期妇女禁用。
3.对阿司匹林过敏的哮喘患者禁用。
【适应症】适用于缓解下列症状：牙痛、头痛、原发性痛经，肩痛、肌痛及运动后损伤性疼痛；劳损、腱鞘炎、滑囊炎引起的疼痛；骨关节炎引起的关节肿痛；以及普通感冒或流行性感冒引起的发热。
【药物相互作用】1.本品与其他解热、镇痛、抗炎药物同用时可增加胃肠道不良反应，并可能导致溃疡。
2.本品与肝素、双香豆素等抗凝药同用时，可导致凝血酶原时间延长，增加出血倾向。
3.本品与地高辛、甲氨蝶呤、口服降血糖药物同用时，能使这些药物的血药浓度增高，不宜同用。
4.本品与呋塞米（呋喃苯胺酸）同用时，后者的排钠和降压作用减弱；与抗高血压药同用时，也降低后者的降压效果。
布洛芬软胶囊说明书
布洛芬软胶囊说明书一、药品名称布洛芬软胶囊二、成分每粒布洛芬软胶囊含有布洛芬20毫克。
三、性状本品为软胶囊剂，胶囊内容物为白色或几乎白色颗粒状固体。
四、适应症本品适用于缓解轻度至中度疼痛、退烧和消除炎症。
五、用法与用量布洛芬软胶囊可口服，建议空腹服用。
成人、青少年及儿童均可服用，但在使用过程中需要根据年龄和体重调整剂量。
以下为一般推荐用量：- 对于成人和青少年：每次口服一粒，每天2-3次，最大剂量不超过每天6粒。
- 对于儿童：请在医生的指导下使用。
六、注意事项1. 请勿超过推荐用量或服用频率。
2. 过量使用可能导致严重的肝脏损害，请遵循医生或药师的建议使用。
3. 如出现不适或持续症状，请停止使用并咨询医生。
4. 对本品成分过敏的人士请勿使用本药。
5. 儿童、孕妇和哺乳期妇女在使用前请咨询医生。
6. 本品不适用于重度疼痛或炎症或作为长期使用的止痛药。
7. 存放在儿童无法接触的地方，避免暴露于阳光直射和高温环境。
七、药物相互作用1. 请告知医生或药师您正在使用的其他药物，包括处方药、非处方药和保健品。
2. 布洛芬可能会与某些药物发生相互作用，请咨询医生或药师以获取更多信息。
八、不良反应不良反应包括但不限于头痛、头晕、恶心、呕吐、皮疹、荨麻疹、过敏反应等。
请在使用过程中注意观察，如有不适，请停止使用并咨询医生。
九、药物过量如意外口服过量，应立即就医，并告知医生所服用的药物名称和剂量。
十、药物贮藏请将本品存放在干燥、阴凉处，避免阳光直射。
十一、生产厂家布洛芬软胶囊由XX制药有限公司生产。
十二、日期本说明书的批准日期为XXXX年XX月XX日。
以上是布洛芬软胶囊的说明书，请在使用前仔细阅读说明书并按照医生或药师的指导使用。
如有任何疑问，请咨询医生或药师的意见。
芬必得说明书
芬必得说明书篇一：布洛芬缓释胶囊(芬必得)【通用名称】布洛芬缓释胶囊【英文名称】Ibuprofen Modify-release Capsules【成份】布洛芬【性状】本品为缓释胶囊，内容物为白色球形小丸。
【作用类别】本品为解热镇痛类非处方药药品。
【药理毒理】本品能抑制前列腺素的合成，具有镇痛、解热和抗炎的作用。
且为缓释剂型，可使药物在体内逐渐释放。
每服用一次，可持续12小时止痛。
【药代动力学】【适应症】用于缓解轻至中度疼痛如头痛、关节痛、偏头痛、牙痛、肌肉痛、神经痛、痛经。
也用于普通感冒或流行性感冒引起的发热。
【用法和用量】口服。
成人，一次1粒，一日2次（早晚各一次）。
【不良反应】1.少数病人可出现恶心、呕吐、胃烧灼感或轻度消化不良、胃肠道溃疡及出血、转氨酶升高、头痛、头晕、耳鸣、视力模糊、精神紧张、嗜睡、下肢水肿或体重骤增。
2.罕见皮疹、过敏性肾炎、膀胱炎、肾病综合征、肾乳头坏死或肾功能衰竭、支气管痉挛。
【禁忌】1.对其他非甾体抗炎药过敏者禁用。
2.孕妇及哺乳期妇女禁用。
3.对阿司匹林过敏的哮喘患者禁用。
【注意事项】1.本品为对症治疗药，不宜长期或大量使用，用于止痛不得超过5天，用于解热不得超过3天，如症状不缓解，请咨询医师或药师。
2.必须整粒吞服，不得打开或溶解后服用。
3.不能同时服用其他含有解热镇痛药的药品（如某些复方抗感冒药）。
4.服用本品期间不得饮酒或含有酒精的饮料。
5.有下列情况患者慎用：60岁以上、支气管哮喘、肝肾功能不全、凝血机制或血小板功能障碍（如血友病）。
6.下列情况患者应在医师指导下使用：有消化性溃疡史、胃肠道出血、心功能不全、高血压。
7.如服用过量或出现严重不良反应，应立即就医。
8.对本品过敏者禁用，过敏体质者慎用。
9.本品性状发生改变时禁止使用。
10.请将本品放在儿童不能接触的地方。
11.如正在使用其他药品，使用本品前请咨询医师或药师。
【孕妇及哺乳期妇女用药】【儿童用药】【老年患者用药】【药物相互作用】1.本品与其他解热、镇痛、抗炎药物同用时可增加胃肠道不良反应，并可能导致溃疡。
布洛芬缓释胶囊说明书
成分本品主要成分为布洛芬。
性状本品为胶囊剂，内容物为白色球形小丸。
适应症本品适用于缓解轻至中度疼痛如头痛、关节痛、偏头痛、牙痛、肌肉痛、神经痛、痛经。
也用于普通感冒或流行性感冒引起的发热。
规格0.3g。
用法用量口服，成人，一次1粒，一日2次（早晚各一次）。
不良反应1、用非甾体抗炎药治疗，有出现水肿、高血压、液体潴留和心力衰竭的报道。
2、罕见皮疹、荨麻疹、瘙痒。
极罕见严重皮肤过敏反应，剥脱性皮炎、史蒂文斯-约翰逊综合征（Stevens Johnson Syndrome）或大疱性皮肤病，如多形性红斑和表皮坏死松解症。
3、罕见过敏性肾炎、膀胱炎、肾病综合征、肾乳头坏死或肾功能衰竭。
尤其注意在长期使用时，通常伴有血清尿素水平升高和水肿。
罕见支气管痉挛和哮喘加重。
4、有肠道疾病，如溃疡性结肠炎和克隆氏病（Crohn’s disease）既往史者，有可能加重病情。
5、极罕见造血障碍（贫血、白细胞减少症、血小板减少症、全血细胞减少症、粒细胞缺乏症，初始症状为：发热、咽喉痛、浅表性口腔溃疡、流感样症状、重度疲劳、出现原因不明的瘀伤或出血）或肝病，肝功能衰竭，肝炎。
6、极罕见严重过敏反应，症状包括：面部、舌和咽喉水肿、呼吸困难、心动过速、低血压（过敏反应、血管性水肿或休克）。
7、少数病人可出现恶心、呕吐、腹痛、腹泻、便秘、肠胃气胀、胃烧灼感或轻度消化不良、胃肠道溃疡及出血、氨基转移酶升高、头痛、头晕、耳鸣、视力模糊、精神紧张、嗜睡、下肢水肿或体重骤增。
8、在自身免疫性疾病患者中（如系统性红斑狼疮、混合性结缔组织病），布洛芬治疗期间有发生无菌性脑膜炎症状的个别案例，如颈强直、头痛、恶心、呕吐、发热或意识混乱。
禁忌1、对本品及其他非甾体抗炎药过敏者禁用。
2、孕妇及哺乳期妇女禁用。
3、对阿司匹林过敏的哮喘患者禁用。
4、严重肝、肾功能不全者或严重心力衰竭者禁用。
5、正在服用其他含有布洛芬或其他非甾体抗炎药，包括服用已知是特异性环氧化酶-2抑制剂药物的患者禁用。
布洛芬缓释胶囊(联邦缓士芬)的说明书
布洛芬缓释胶囊(联邦缓士芬)的说明书体内出现镇痛和发热症状，往往都是由于有炎症造成的，治疗体热镇痛是刻不容缓的，但是光消炎可起不到治愈的目的。
目前治疗解热镇痛的药物当中，布洛芬缓释胶囊(联邦缓士芬)就是最好的一种了。
它对于解热镇痛抗炎的效果非常显著，是一种纯天然制剂，对人体没有任何副作用，您可以放心使用。
【药品名称】通用名称：布洛芬缓释胶囊商品名称：布洛芬缓释胶囊(联邦缓士芬)拼音全码：BuLuoFenHuanShiJiaoNang(LianBangHuanShiFen) 【主要成份】布洛芬【性状】本品为缓释胶囊，内容物为白色球形小丸。
【适应症/功能主治】用于缓解轻至中度疼痛如头痛、关节痛、偏头痛、牙痛、肌肉痛、神经痛、痛经。
也用于普通感冒或流行性感冒引起的发热。
【规格型号】0.3g*12s【用法用量】口服。
成人，一次1粒，一日2次（早晚各一次）。
【不良反应】 1.少数病人可出现恶心、呕吐、胃烧灼感或轻度消化不良、胃肠道溃疡及出血、转氨酶升高、头痛、头晕、耳鸣、视力模糊、精神紧张、嗜睡、下肢水肿或体重骤增。
2.罕见皮疹、过敏性肾炎、膀胱炎、肾病综合征、肾乳头坏死或肾功能衰竭、支气管痉挛。
【禁忌】 1.对其他非甾体抗炎药过敏者禁用。
2.孕妇及哺乳期妇女禁用。
3.对阿司匹林过敏的哮喘患者禁用。
【注意事项】 1.本品为对症治疗药，不宜长期或大量使用，用于止痛不得超过5天，用于解热不得超过3天，如症状不缓解，请咨询医师或药师。
2.必须整粒吞服，不得打开或溶解后服用。
3.不能同时服用其他含有解热镇痛药的药品（如某些复方抗感冒药）。
4.服用本品期间不得饮酒或含有酒精的饮料。
5.有下列情况患者慎用：60岁以上、支气管哮喘、肝肾功能不全、凝血机制或血小板功能障碍（如血友病）。
6.下列情况患者应在医师指导下使用：有消化性溃疡史、胃肠道出血、心功能不全、高血压。
7.如服用过量或出现严重不良反应，应立即就医。
布洛芬缓释胶囊Ibuprofen-详细说明书与重点
布洛芬缓释胶囊Ibuprofen商品名：芬必得英文名：Ibuprofen Sustained-Release Capsules汉语拼音：Bu Luo Fen Huan Shi Jiao Nang【成份】本品每粒含主要成份布洛芬0.3克。
辅料为：糖、淀粉、硬脂酸、聚乙烯吡咯烷酮。
【性状】本品内容物为白色球形小丸。
【适应症】用于缓解轻至中度疼痛如头痛、关节痛、偏头痛、牙痛、肌肉痛、神经痛、痛经。
也用于普通感冒或流行性感冒引起的发热。
【规格】0.3克。
【用法用量】口服。
成人，一次1粒，一日2次（早晚各一次）。
【不良反应】1.少数病人可出现恶心、呕吐、腹痛、腹泻、便秘、肠胃气胀、胃烧灼感或轻度消化不良、胃肠道溃疡及出血、转氨酶升高、头痛、头晕、耳鸣、视力模糊、精神紧张、嗜睡、下肢水肿或体重骤增。
2.罕见皮疹、荨麻疹、瘙痒。
极罕见严重皮肤过敏反应，剥脱性皮炎、史蒂文斯－约翰逊综合征（StevensJohnsonSyndrome）或大疱性皮肤病，如多形性红斑和表皮坏死松解症。
3.罕见过敏性肾炎、膀胱炎、肾病综合征、肾乳头坏死或肾功能衰竭，尤其注意在长期使用时，通常伴有血清尿素水平升高和水肿。
罕见支气管痉挛和哮喘加重。
4.有肠道疾病，如溃疡性结肠炎和克隆氏病（Crohn’sdisease）既往史者，有可能加重病情。
5.极罕见造血障碍（贫血、白细胞减少症、血小板减少症、全血细胞减少症、粒细胞缺乏症，初始症状为：发热、咽喉痛、浅表性口腔溃疡、流感样症状、重度疲劳、出现原因不明的瘀伤或出血）或肝病，肝功能衰竭，肝炎。
6.极罕见严重过敏反应，症状包括：面部、舌和咽喉水肿、呼吸困难、心动过速、低血压（过敏反应、血管性水肿或休克）。
7.用非甾体抗炎药治疗，有出现水肿、高血压、液体潴留和心力衰竭的报道。
8.在自身免疫性疾病患者中，（如系统性红斑狼疮、混合性结缔组织病）布洛芬治疗期间有发生无菌性脑膜炎症状的个别案例，如颈强直、头痛、恶心、呕吐、发热或意识混乱。
bluenin 说明书
bluenin 说明书【药品名称】通用名称：布洛芬缓释胶囊商品名称：芬必得英文名称：Ibuprofen Sustained Release Capsules汉语拼音：Buluofen Huanshi Jiaonang【成份】本品每粒含主要成份布洛芬0.3克。
辅料为：糖、淀粉、硬脂酸、聚乙烯吡咯烷酮。
【性状】本品内容物为白色球形小丸。
【适应症】用于缓解轻至中度疼痛如头痛、偏头痛、牙痛、痛经、关节痛、肌肉痛、神经痛，也用于普通感冒或流行性感冒引起的发热。
【用法用量】口服。
成人，一次1片，一日2次（早晚各一次）。
【不良反应】 1.少数病人可出现恶心、呕吐、胃烧灼感或轻度消化不良、胃肠道溃疡及出血、转氨酶升高、头痛、头晕、耳鸣、视力模糊、精神紧张、嗜睡、下肢水肿或体重骤增。
2.罕见皮疹、过敏性肾炎、膀胱炎、肾病综合征、肾坏死或肾功能衰竭、支气管痉挛。
【禁忌】 1.对其他非甾体抗炎药过敏者禁用。
2.孕妇及哺乳期妇女禁用。
3.对阿司匹林过敏的哮喘者禁用。
【注意事项】 1.本品为对症治疗药，自我用药不宜长期或大量使用，用于止痛不得超过5天，用于解热不得超过3天，如症状不缓解，请咨询医师或药师。
2.对本品及其他解热、镇痛抗炎药物过敏者禁用。
过敏体质者慎用。
3.必须整粒吞服，不得打开或溶解后服用。
4.不能同时服用其他含有解热镇痛药的药品（如某些复方抗感冒药）。
5.服用本品期间不得饮酒或含有酒精的饮料。
6.肠胃病患者使用前请咨询医师或药师。
7.有下列情况患者慎用：60岁以上、支气管哮喘、肝肾功能不全、凝血机制或血小板功能障碍（如血友端正或其他出血性疾病）。
.下列情况患者应在【特殊人群用药】儿童注意事项：儿童必须在成人监护下使用。
妊娠与哺乳期注意事项：慎用。
老人注意事项：老年患者由于肝、肾功能发生减退，易发生不良反应，应慎用或适当减量使用。
【药物相互作用】 1. 本品与其他解热、镇痛、抗炎药物同用时可增加胃肠道不良反应，并可能导致溃疡。
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PACKAGE LEAFLET: INFORMATION FOR THE USER Seractil® 400mg film-coated Tablets(dexibuprofen)Your medicine is available using the name Seractil 400mg film-coated Tablets but will be referred to as Seractil throughout this leaflet.Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.Keep this leaflet. You may need to read it again.If you have any more questions, ask your doctor or pharmacist.This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs ofillness are the same as yours.If you get any side effects, talk to your doctor orpharmacist. This includes any possible side effects not listed in this leaflet.What is in this leaflet1.What Seractil is and what it is used for2.What you need to know before you take Seractil3.How to take Seractil4.Possible side effects5.How to store Seractil6.Contents of the pack and other information1.What Seractil is and what it is used forDexibuprofen, the active ingredient in Seractil, belongs to a family of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs such as dexibuprofen are used as a painkiller and to control inflammation. They work by reducing the amount of prostaglandins (substances that control inflammation and pain) your body produces.What is Seractil used for?Seractil is used to relieve:pain and inflammation caused by osteoarthritis (when your joints become worn);period (menstrual) pain;mild to moderate pain, such as pains in the muscles and joints and toothaches.2.What you need to know before you takeSeractilDo not take Seractil if:you are allergic to dexibuprofen or any of the other ingredients of this medicine (listed in section 6);you are allergic to acetylsalicylic acid or other pain-killers (your allergy may cause you to have difficulty breathing,asthma, a runny nose, a skin rash or swelling to your face); you previously had bleedings or perforations in your gastrointestinal system caused by NSAIDs;you have, or have ever had, peptic ulceration (ulcer in your stomach or duodenum) or bleeding in your digestive tract; you have bleedings in the brain (cerebrovascular bleedings) or other active bleedings;you currently have a flare up of an inflammatory disease of the intestines (ulcerative colitis, Crohn’s disease);you have serious heart failure or serious liver or kidney disease;from the beginning of the 6th month of pregnancy.Warnings and precautionsTalk to your doctor or pharmacist before taking Seractil, ifyou ever have had a stomach or duodenal ulcer;you have had bowel ulcers, ulcerative colitis or Crohn’s disease;you have liver or kidney disease or you are addicted to alcohol;you have blood clotting disorders (also see the ‘Taking other medicines’ section);you have oedema (when fluid collects in your body tissues); you have a heart disease or high blood pressure;you have asthma or any other breathing problems;you suffer from systemic lupus erythematosus (a disease which affects joints, muscles and skin) or mixed collagenosis(a collagen disease which affects connective tissues).Seractil may make it more difficult to become pregnant. You should inform your doctor if you are planning to become pregnant or if you have problems becoming pregnant. Your fertility will return to normal when you stop taking Seractil.If you need higher doses, especially if you are over 60 or if you had stomach or duodenal ulcers, there is an increased risk of gastrointestinal side effects. Your doctor may consider to prescribe protective agents together with Seractil. Medicines such as Seractil may be associated with a smallincreased risk of heart attack (“myocardial infarction”) or stroke.Any risk is more likely with high doses and prolonged treatment.Do not exceed the recommended dose or duration of treatment.If you have heart problems, previous stroke or think that youmight be at risk of these conditions (for example if you have highblood pressure, diabetes or high cholesterol or are a smoker) youshould discuss your treatment with your doctor or pharmacist.Your doctor may need to give you regular check-ups if:you have heart, liver or kidney problems;you are older than 60;you need to take this medicine for long-term treatment.Your doctor will tell you how often you need these check-ups.You can get a headache if you take high doses of painkillers for along time (off label use). In this case you must not take moreSeractil for the headache.You should avoid taking NSAIDs if you have a varicella zosterinfection (chickenpox).Some patients might experience a delayed onset of action ifSeractil is taken for a quick pain relief in acute pain conditions,especially if taken with food (see also section 3).Other medicines and SeractilTell your doctor or pharmacist if you are taking, have recentlytaken or might take any other medicines.You should not take the following medicines with Seractil unlessyou are under close medical supervision:Non-steroidal anti-inflammatory drugs (medicines for pain,fever and inflammation). There is an increased risk of ulcersand bleedings in the digestive system if you take Seractilwith other NSAIDs or acetylsalicylic acid (aspirin). Do nottake if you are taking aspirin at doses of above 75 mg daily.Warfarin or other medicines used to thin the blood or stopblood clots. If you take this medicine with Seractil it canprolong bleeding time or bleeding can occur.Lithium used to treat certain mood disorders. Seractil canincrease the effect of lithium.Methotrexate. Seractil can increase the side effects ofmethotrexate.You may take the following medicines but for safety reasons youshould tell your doctor:Medicines used to treat high blood pressure or heartproblems (for example, beta blockers). Seractil may reducethe benefits of these medicines.Certain heart medicines called ACE-inhibitors or AngiotensinII receptor antagonists. They may increase the risk ofkidney problems in rare cases.Diuretics (water tablets).Corticosteroids. The risk for ulcers and bleeding mayincrease.Certain antidepressants (selective serotonin reuptakeinhibitors) may increase the risk for gastro intestinalbleeding.Digoxin (a heart medicine). Seractil can increase the sideeffects of digoxin.Immune suppressants like ciclosporin.Aminoglycoside antibiotics (medicines to treat infections)Medicines that increase potassium levels in the blood: ACEinhibitors, angiotensin-II receptor antagonists, ciclosporin,tacrolimus, trimethoprim and heparins.Drugs used to stop or prevent blood clots. Seractil maymake your body take longer to stop bleeding.Phenytoin used to treat epilepsy. Seractil may increase theside effects of phenytoin.Phenytoin, phenobarbital and rifampicin. Concomitantadministration may lower the effects of dexibuprofen.Low dose aspirin (up to 75 mg). Seractil may interfere withthe effect of aspirin to thin the blood.Sulfonylurea (certain oral anti-diabetic medicines)Pemetrexed (a medicine to treat certain forms of cancer)Zidovudine (a medicine to treat HIV/AIDS)Seractil with food, drink and alcoholYou may take Seractil without food, but it is better to take it witha meal as this may help to avoid stomach problems, particularly ifyou take it for long term use.You should limit or avoid drinking alcohol when you are takingSeractil as this may increase gastrointestinal side effects.Pregnancy, breastfeeding and fertilityIf you are pregnant or breast-feeding, think you may be pregnantor are planning to have a baby, ask your doctor for advice beforetaking this medicine.You must not take Seractil from the beginning of the 6th month ofpregnancy, as this may seriously harm your unborn baby, even atvery low doses.In the first five months of pregnancy you should only use Seractilafter consulting your doctor.You also should not take Seractil if you plan to become pregnant,as the medicine may make it more difficult to become pregnant.Only small amounts of Seractil pass into breast milk. However, ifyou are breast-feeding, you should not take Seractil for longperiods or in high doses.Driving and using machinesIf you have side effects like feeling dizzy, drowsy, tired, or if youhave blurred vision after taking Seractil, you should avoid drivingor using any dangerous machines (see section 4 Possible sideeffects).3.How to take SeractilAlways take this medicine exactly as your doctor has told you.Check with your doctor or pharmacist if you are not sure.You should take Seractil with a glass of water or some otherliquid. Seractil works faster if you take it without food. Taking itwith food is recommended as this may help to avoid stomachproblems, particularly if you take it for long term use.Do not take more than 1 Seractil 400mg tablet for a single dose.Do not take more than 3 Seractil 400mg tablets a day.For osteoarthritisThe recommended dose is 1 Seractil 400mg tablet 2 times a day(1 in the morning and 1 in the evening). For acute symptoms,your doctor may increase the dose to 3 Seractil 400mg tablets aday.For period (menstrual) painThe recommended dose is 1 Seractil 400mg tablet 2 times a day.For mild to moderate painThe recommended dose is 200 mg Seractil (half a 400 mg tablet)3 times a day. If higher doses are needed your doctor mayprescribe up to 3 Seractil 400mg tablets a day. Depending on yoursymptoms, the doctor may also prescribe lower strength Seractiltablets (300 mg).The score lines on the tablets (see the ‘What Seractil looks like’section) make it possible for you to split the tablets into equaldoses.Patients with liver or kidney disease: Your doctor may haveprescribed a lower than the normal dose of Seractil. You must notincrease the dose your doctor has prescribed.Elderly patients: If you are over 60 years old, your doctor mayhave prescribed a lower dose than normal. If you are not havingproblems taking Seractil, your doctor may increase your dose.Use in children and adolescents: As there is not enoughexperience in children and adolescents Seractil should not be usedbelow the age of 18.If you feel that the effects of your Seractil tablets are too strongor too weak, talk to your doctor or pharmacist.If you take more Seractil than you shouldIf you have accidentally taken too many tablets, contact yourdoctor straight away.If you forget to take SeractilDo not take a double dose to make up for a forgotten tablet.If you have any further questions on the use of this medicine, askyour doctor or pharmacist.4.Possible side effectsLike all medicines, this medicine can cause side effects, althoughnot everybody gets them.These do not happen as often when you take a low dose or youtake Seractil for only a short time.If you suffer from any of the following at any time during yourtreatment stop taking the medicine and seek immediatemedical help:Pass blood in your faeces (stools/motions)Pass black tarry stoolsVomit any blood or dark particles that look like coffeegrounds.Stop taking the medicine and tell your doctor if you experienceindigestion or heartburn, abdominal pain (pains in your stomach)or other abnormal stomach symptoms.PACKAGE LEAFLET: INFORMATION FOR THE USER Dexibuprofen 400mg film-coated Tablets Your medicine is available using the name Dexibuprofen 400mg film-coated Tablets but will be referred to as Dexibuprofen throughout this leaflet.Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.Keep this leaflet. You may need to read it again.If you have any more questions, ask your doctor or pharmacist.This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs ofillness are the same as yours.If you get any side effects, talk to your doctor orpharmacist. This includes any possible side effects not listed in this leaflet.What is in this leaflet1.What Dexibuprofen is and what it is used for2.What you need to know before you take Dexibuprofen3.How to take Dexibuprofen4.Possible side effects5.How to store Dexibuprofen6.Contents of the pack and other information1.What Dexibuprofen is and what it is usedforDexibuprofen, the active ingredient in Dexibuprofen, belongs to a family of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs such as dexibuprofen are used as a painkiller and to control inflammation. They work by reducing the amount of prostaglandins (substances that control inflammation and pain) your body produces.What is Dexibuprofen used for?Dexibuprofen is used to relieve:pain and inflammation caused by osteoarthritis (when your joints become worn);period (menstrual) pain;mild to moderate pain, such as pains in the muscles and joints and toothaches.2.What you need to know before you takeDexibuprofenDo not take Dexibuprofen if:you are allergic to dexibuprofen or any of the other ingredients of this medicine (listed in section 6);you are allergic to acetylsalicylic acid or other pain-killers (your allergy may cause you to have difficulty breathing,asthma, a runny nose, a skin rash or swelling to your face); you previously had bleedings or perforations in your gastrointestinal system caused by NSAIDs;you have, or have ever had, peptic ulceration (ulcer in your stomach or duodenum) or bleeding in your digestive tract; you have bleedings in the brain (cerebrovascular bleedings) or other active bleedings;you currently have a flare up of an inflammatory disease of the intestines (ulcerative colitis, Crohn’s disease);you have serious heart failure or serious liver or kidney disease;from the beginning of the 6th month of pregnancy.Warnings and precautionsTalk to your doctor or pharmacist before taking Dexibuprofen, ifyou ever have had a stomach or duodenal ulcer;you have had bowel ulcers, ulcerative colitis or Crohn’s disease;you have liver or kidney disease or you are addicted to alcohol;you have blood clotting disorders (also see the ‘Taking other medicines’ section);you have oedema (when fluid collects in your body tissues); you have a heart disease or high blood pressure;you have asthma or any other breathing problems;you suffer from systemic lupus erythematosus (a disease which affects joints, muscles and skin) or mixed collagenosis(a collagen disease which affects connective tissues). Dexibuprofen may make it more difficult to become pregnant. You should inform your doctor if you are planning to become pregnant or if you have problems becoming pregnant. Your fertility will return to normal when you stop taking Dexibuprofen. If you need higher doses, especially if you are over 60 or if you had stomach or duodenal ulcers, there is an increased risk of gastrointestinal side effects. Your doctor may consider to prescribe protective agents together with Dexibuprofen. Medicines such as Dexibuprofen may be associated with a smallincreased risk of heart attack (“myocardial infarction”) or stroke.Any risk is more likely with high doses and prolonged treatment.Do not exceed the recommended dose or duration of treatment.If you have heart problems, previous stroke or think that youmight be at risk of these conditions (for example if you have highblood pressure, diabetes or high cholesterol or are a smoker) youshould discuss your treatment with your doctor or pharmacist.Your doctor may need to give you regular check-ups if:you have heart, liver or kidney problems;you are older than 60;you need to take this medicine for long-term treatment.Your doctor will tell you how often you need these check-ups.You can get a headache if you take high doses of painkillers for along time (off label use). In this case you must not take moreDexibuprofen for the headache.You should avoid taking NSAIDs if you have a varicella zosterinfection (chickenpox).Some patients might experience a delayed onset of action ifDexibuprofen is taken for a quick pain relief in acute painconditions, especially if taken with food (see also section 3).Other medicines and DexibuprofenTell your doctor or pharmacist if you are taking, have recentlytaken or might take any other medicines.You should not take the following medicines with Dexibuprofenunless you are under close medical supervision:Non-steroidal anti-inflammatory drugs (medicines for pain,fever and inflammation). There is an increased risk of ulcersand bleedings in the digestive system if you takeDexibuprofen with other NSAIDs or acetylsalicylic acid(aspirin). Do not take if you are taking aspirin at doses ofabove 75 mg daily.Warfarin or other medicines used to thin the blood or stopblood clots. If you take this medicine with Dexibuprofen itcan prolong bleeding time or bleeding can occur.Lithium used to treat certain mood disorders. Dexibuprofencan increase the effect of lithium.Methotrexate. Dexibuprofen can increase the side effects ofmethotrexate.You may take the following medicines but for safety reasons youshould tell your doctor:Medicines used to treat high blood pressure or heartproblems (for example, beta blockers). Dexibuprofen mayreduce the benefits of these medicines.Certain heart medicines called ACE-inhibitors or AngiotensinII receptor antagonists. They may increase the risk ofkidney problems in rare cases.Diuretics (water tablets).Corticosteroids. The risk for ulcers and bleeding mayincrease.Certain antidepressants (selective serotonin reuptakeinhibitors) may increase the risk for gastro intestinalbleeding.Digoxin (a heart medicine). Dexibuprofen can increase theside effects of digoxin.Immune suppressants like ciclosporin.Aminoglycoside antibiotics (medicines to treat infections)Medicines that increase potassium levels in the blood: ACEinhibitors, angiotensin-II receptor antagonists, ciclosporin,tacrolimus, trimethoprim and heparins.Drugs used to stop or prevent blood clots. Dexibuprofenmay make your body take longer to stop bleeding.Phenytoin used to treat epilepsy. Dexibuprofen mayincrease the side effects of phenytoin.Phenytoin, phenobarbital and rifampicin. Concomitantadministration may lower the effects of dexibuprofen.Low dose aspirin (up to 75 mg). Dexibuprofen may interferewith the effect of aspirin to thin the blood.Sulfonylurea (certain oral anti-diabetic medicines)Pemetrexed (a medicine to treat certain forms of cancer)Zidovudine (a medicine to treat HIV/AIDS)Dexibuprofen with food, drink and alcoholYou may take Dexibuprofen without food, but it is better to take itwith a meal as this may help to avoid stomach problems,particularly if you take it for long term use.You should limit or avoid drinking alcohol when you are takingDexibuprofen as this may increase gastrointestinal side effects.Pregnancy, breastfeeding and fertilityIf you are pregnant or breast-feeding, think you may be pregnantor are planning to have a baby, ask your doctor for advice beforetaking this medicine.You must not take Dexibuprofen from the beginning of the 6thmonth of pregnancy, as this may seriously harm your unbornbaby, even at very low doses.In the first five months of pregnancy you should only useDexibuprofen after consulting your doctor.You also should not take Dexibuprofen if you plan to becomepregnant, as the medicine may make it more difficult to becomepregnant.Only small amounts of Dexibuprofen pass into breast milk.However, if you are breast-feeding, you should not takeDexibuprofen for long periods or in high doses.Driving and using machinesIf you have side effects like feeling dizzy, drowsy, tired, or if youhave blurred vision after taking Dexibuprofen, you should avoiddriving or using any dangerous machines (see section 4 Possibleside effects).3.How to take DexibuprofenAlways take this medicine exactly as your doctor has told you.Check with your doctor or pharmacist if you are not sure.You should take Dexibuprofen with a glass of water or some otherliquid. Dexibuprofen works faster if you take it without food.Taking it with food is recommended as this may help to avoidstomach problems, particularly if you take it for long term use.Do not take more than 1 Dexibuprofen 400mg tablet for a singledose.Do not take more than 3 Dexibuprofen 400mg tablets a day.For osteoarthritisThe recommended dose is 1 Dexibuprofen 400mg tablet 2 times aday (1 in the morning and 1 in the evening). For acutesymptoms, your doctor may increase the dose to 3 Dexibuprofen400mg tablets a day.For period (menstrual) painThe recommended dose is 1 Dexibuprofen 400mg tablet 2 times aday.For mild to moderate painThe recommended dose is 200 mg Dexibuprofen (half a 400 mgtablet) 3 times a day. If higher doses are needed your doctor mayprescribe up to 3 Dexibuprofen 400mg tablets a day. Dependingon your symptoms, the doctor may also prescribe lower strengthDexibuprofen tablets (300 mg).The score lines on the tablets (see the ‘What Dexibuprofen lookslike’ section) make it possible for you to split the tablets into equaldoses.Patients with liver or kidney disease: Your doctor may haveprescribed a lower than the normal dose of Dexibuprofen. Youmust not increase the dose your doctor has prescribed.Elderly patients: If you are over 60 years old, your doctor mayhave prescribed a lower dose than normal. If you are not havingproblems taking Dexibuprofen, your doctor may increase yourdose.Use in children and adolescents: As there is not enoughexperience in children and adolescents Dexibuprofen should notbe used below the age of 18.If you feel that the effects of your Dexibuprofen tablets are toostrong or too weak, talk to your doctor or pharmacist.If you take more Dexibuprofen than you shouldIf you have accidentally taken too many tablets, contact yourdoctor straight away.If you forget to take DexibuprofenDo not take a double dose to make up for a forgotten tablet.If you have any further questions on the use of this medicine, askyour doctor or pharmacist.4.Possible side effectsLike all medicines, this medicine can cause side effects, althoughnot everybody gets them.These do not happen as often when you take a low dose or youtake Dexibuprofen for only a short time.If you suffer from any of the following at any time during yourtreatment stop taking the medicine and seek immediatemedical help:Pass blood in your faeces (stools/motions)Pass black tarry stoolsVomit any blood or dark particles that look like coffeegrounds.Stop taking the medicine and tell your doctor if you experienceindigestion or heartburn, abdominal pain (pains in your stomach)or other abnormal stomach symptoms.。