锯叶棕果实提取物胶囊辅助治疗急性前列腺炎的临床效果

锯叶棕果实提取物胶囊辅助治疗急性前列腺炎的临床效果

作者：孙鑫波陈从波姚启盛

来源：《中国医药导报》2020年第11期

[摘要] 目的观察锯叶棕果实提取物胶囊辅助治疗急性前列腺炎的临床效果。方法选择2017年5月～2018年7月湖北省十堰市太和医院泌尿外科收治的急性前列腺炎患者62例为研究对象，采用随机数字表法将其分为对照组和观察组，每组各31例。对照组给予盐酸坦索罗辛缓释胶囊+双石通淋胶囊+抗生素治疗，观察组给予锯叶棕果实提取物胶囊+双石通淋胶囊+抗生素治疗。4周后检查两组前列腺特异抗原（PSA）、卵磷脂小体（LD）、降钙素原（PCT）、C-反应蛋白（CRP）、血白细胞计数（WBC）、尿白细胞计数（UWBC）、前列腺液白细胞数（PFWBC）、前列腺体积和移行带体积，并比较两组总有效率和不良反应发生率，6个月后随访复发率。结果治疗后，两组PSA、PCT和CRP均低于治疗前，LD高于治疗前，且觀察组PSA、PCT和CRP低于对照组，LD高于对照组（P < 0.05）。两组前列腺体积和移行带体积均低于治疗前，且观察组低于对照组（P < 0.05）。两组WBC、UWBC及PFWBC计数均低于治疗前，且观察组低于对照组（P < 0.05）。观察组总有效率高于对照组（P < 0.05）。观察组不良反应总发生率和复发率低于对照组（P < 0.05）。结论锯叶棕果实提取物胶囊作为急性前列腺炎的辅助治疗可增强传统治疗方法的临床效果。

[关键词] 急性前列腺炎;锯叶棕果实提取物胶囊;临床效果;不良反应;复发率

[中图分类号] R697.3 ; ; ; ; ;[文献标识码] A ; ; ; ; ;[文章编号] 1673-7210（2020）04（b）-0161-04

Clinical effect of Saw Palmetto Fruit Extract Capsules in the treatment of acute prostatitis

SUN Xinbo ; CHEN Congbo ; YAO Qisheng

Department of Urology， Taihe Hospital， Affiliated Taihe Hospital to Hubei University of Medicine， Hubei Province， Shiyan ; 442000， China

[Abstract] Objective To observe the clinical effect of Saw Palmetto Fruit Extract Capsules on acute prostatitis. Methods From May 2017 to July 2018， a total of 62 patients with acute prostatitis admitted to the Department of Urology， Taihe Hospital， Shiyan City， Hubei Province were selected as the study subjects. According to the random number table method， they were divided into control group and observation group， with 31 cases in each group. The control group was treated with Tansoroxin Hydrochloride Sustained-Release Capsules + Shuangshitonglin Capsules + Antibiotics， and the observation group was treated with Saw Palmetto Fruit Extract Capsules + Shuangshitonglin Capsules + Antibiotics. After 4 weeks， prostate specific antigen （PSA），lecithin body （LD）， procalcitonin （PCT）， C-reactive protein （CRP）， blood white blood cell count （WBC）， urine white blood cell count （UWBC）， prostatic fluid white blood cell count （PFWBC）， prostate volume and transitional band volume were examined. The total effective rates and the incidence of adverse reactions were compared between the two groups. The recurrence rate was followed up 6 months later. Results After treatment， PSA， PCT and CRP in two groups were lower than before treatment， and LD was higher than before treatment，moreover， PSA， PCT and CRP in the observation group were lower than those in the control group， LD was higher than that in the control group （P < 0.05）. Prostate volume and transitional band volume in both groups were lower than before treatment， and the observation group was lower than the control group （P < 0.05）. WBC， UWBC and PFWBC in two groups were lower than before treatment， and those in the observation group was lower than those in the control group （P < 0.05）. The total effective rate of the observation group was higher than that of the control group （P < 0.05）. The total incidence of adverse reactions and recurrence rate in the observation group were lower than those in the control group （P < 0.05）. Conclusion Saw Palmetto Fruit Extract Capsules as an adjuvant treatment of acute prostatitis can enhance the clinical efficacy of traditional treatment methods.

[Key words] Acute prostatitis; Saw Palmetto Fruit Extract Capsules; Clinical efficacy; Adverse reactions; Recurrence rate

急性前列腺炎是前列腺急性炎症性疾病，以成年男性多见，目前有低龄化和发病率逐年上升趋势[1]。临床表现以尿频、尿急、尿痛、排尿困难、直肠及会阴部疼痛等为主[2]。前列腺管上行感染或上尿路感染下行是引起前列腺感染的主要病因[3]。因前列腺微循环不够发达，抗生素很难完全进入腺体内发挥根治作用，故其治愈率低且复发率高，部分患者易转化为慢性前列腺炎。鉴于此，加强中医中药配合抗生素治疗还有深入研究之价值。国外有报道认为锯叶棕果实提取物胶囊是目前治疗前列腺疾病的最有效的天然植物制剂[4]。国内虽有相关应用，但无治疗急性前列腺炎的报道，本研究重点观察该药辅助治疗急性前列腺炎的临床效果，现报道如下：

1 资料与方法