最全有机实验记录英文描述总结
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最全有机实验记录英文描述总结
一、加料过程常用表述
1. 添加试剂
2. 催化量的
3. 气体保护
4. 通入气体
5. 通过双针头导管加料
6. 通过注射器加料
二、反应过程常用表述
1. 反应检测
2. 放置过夜
3. 甲苯/乙醇带水
4. 氢化反应
5. 分水器
6. 反应放热
7. 微波反应
三、后处理过程常用表述
1. 过滤
2. 淬火
3. 磨碎
4. 在两相中分开
5. 静止固化
6. 在冻干机冻干
7. 纯化
过柱
制备HPLC纯化
制备TLC纯化
重结晶
8. 调pH
9. 萃取
10. 浓缩
11. 干燥
干燥
真空干燥
四、部分常见反应现象描述
1. 加料放热
2. 反应过程中或者降温有固体析出
3. 加料不溶解
4. 加热溶解
5. 反应变粘稠/变色
五、特殊结果叙述
1. 无进一步处理
2. 统一和其他批次一起后处理
3. 检测条件，不需要后处理
六、一些易错写法
一、加料过程常用表述
1. 添加试剂
To a mixture (suspension / solution / slurry) ofcompound 12 (487 mg, 1 mmol) and o-plenylenediamine (648 mg, 6 mmol) inCH2Cl2 (15 mL) being cooled to 0o C was addedthe DCC (226 mg, 1.1 mmol).
Anhydrous lithium iodide (1.38 g, 10.3 mmol) was added the five portions (dropwise/ in one portion / in portions) to a stirred solution of compound 12 (10.93 g, 51.5mmol) in CH2Cl2(120 mL).
A round-bottom flask was charged with compound 3 (1.75 g, 5.27 mmol), LiCl (1.17 g, 26.3 mmol), DMSO (100 mL) and H2O (378ul)
2. 催化量的
Et3N (20 mL, 142 mmol) and a catalyticamount of DMAP were added the solution of compound 1 (4.549 g, 46.4mmol) in CH2Cl2 (120 mL) at 0o C
3. 气体保护
To a stirred -78o Csolution of trimethylsilyacetylene (4.44 g, 45.5 mmol) in THF (10 mL) under Argon wasadded dropwise n-butylithium (1.6 M in hexane, 28.25 mL).
4. 通入气体
An ozone-enriched steam of oxygen was bubbled througha cold (-78o C) solution of compound 9 (128 mg, 1.409 mmol) in CH2Cl2 (5 mL) untilit turned light blue. The solution was purged with argon at -78o Cfor 10 min to remove the excess O3.
5. 通过双针头导管加料
The mixture was added to a solution of compound 2 (3.00 g, 12.8 mmol) in THF (48mL) via cannula over a period of 30 min.
A solution of compound 29 (100 mg, 0.19 mmol, 1.0 equiv) in dry DMSO (1.5 mL) wascannulated under Argon to a vigorously stirred mixture of powered potassiumsuperoxide (62 mg, 0.87 mmol, 4.5 equiv) and 18-crown-6-ether (23 mg, 0.087mmol, 0.45 equiv) in dry DMSO (0.5 mL).
6. 通过注射器加料
To a stirred solution of compound 15 (8.61 g, 21.2 mmol)was added a solution of p-toluenesulfonicacid (6.0 g) in CH2Cl2via syringe over 5 min.
二、反应过程常用表述
1. 反应检测
After 1 h, TLC analysis (CH2Cl2/ hexane 3:1) showed the complete consumption of compound 15.
2. 放置过夜
The mixture was left standing overnight.
3. 甲苯/乙醇带水
Compound A(1.97 g, 6.63 mmol) was coevaporatedwith toluene five times to remove the water.
The residue was subjected to toluene azeotrope to givethe corresponding acid chloride as brown oil.
The aqueous portion was concentrated underreduced pressure followed by azeotropic removal of water with absolute EtOH
4. 氢化反应
A mixture of compound 1 (190 g, 0.88mmol) and Raney Ni (20 g) inethanol (1500 mL) and ethyl acetate (500 mL) was stirred under 1 atm at room temperaturefor an hour.
5. 分水器
A mixture of TsOH.H2O (56.91 g, 0.3 mol) and toluene (400 mL) washeated to reflux to remove water by Dean-Stark trap.
6. 反应放热
The reaction was exothermic.