Generalized Hamming Weights of Irreducible Cyclic Codes

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F q Set of q Alphabets

F q Set of q Alphabets
α Sk β Sk
: : : : : : : : : : : : : : : : : : : : : : : : : : : :
ˆk Generator matrix of S r th -order Reed M¨ uller Code Binary nonlinear Preparata Code Binary nonlinear Kerdock Code max{M | there exists a binary (n, M, dH ) code } Gray map {φ(c) : c ∈ C} : Gray image of C Irreducible polynomial over Z2 such that it divides xn − 1 over Z2 Hensel uplift of h2 (x) over Z4 p-basis of C p-dimension of C Generalized gray map Generalized gray image of C Generalized gray image of C in 2-basis form Binary residue code of C Binary torsion code of C Correlation of c ∈ C Simplex Code of type α Simplex Code of type β
Synopsis
Name of the student: Manish Kumar Gupta Degree for which submitted: Ph.D. Thesis Title: On Some Linear Codes over Z2s Name of the Thesis Supervisors: Prof. M. C. Bhandari & Prof. A. K. Lal Month and Year of Thesis Submission: December, 1999 Roll No.: 9310863 Department: Mathematics

Asymptotic Weight Distributions of Irregular Repeat-Accumulate Codes

Asymptotic Weight Distributions of Irregular Repeat-Accumulate Codes

Abstract— In this paper, the average input-parity weight enumerator (AIPWE) of regular/irregular repeat-accumulate (RA) ensembles is derived, by viewing an RA code as a serial concatenation of an outer low-density generator matrix (LDGM) code and an inner accumulator. The exact average weight distribution (AWD) of the systematic and nonsystematic versions of the RA ensembles are then obtained from their AIPWE’s. We further derive the asymptotic growth exponent of the AWD’s, which are then used to bound the ensemble performance under maximum likelihood (ML) decoding. It is shown that simple nonsystematic regular RA ensembles outperform systematic regular RA and regular low-density parity-check (LDPC) ensembles and have distance spectrum which closely resembles that of the random ensemble.

中国教育优缺点英语作文

中国教育优缺点英语作文

中国教育优缺点英语作文The Pros and Cons of Education in ChinaEducation, being the backbone of any society, plays a pivotal role in shaping the future of its youth. China, with its rich cultural heritage and historical context, has a unique education system that has both distinct advantages and some notable challenges.Advantages of Chinese Education:1.Emphasis on Basics:Chinese education systems, especially at the primary andsecondary levels,focus heavily on fundamental skills such as mathematics, science,and language arts.This ensures a solid foundation for students, preparing them well for further academic and professional pursuits.2.Cultural Preservation:Chinese education strongly values the preservation andpromotion of its rich cultural heritage.This is evident in the integration of traditional subjects like Chinese literature and history, which foster a sense of cultural pride and identity among students.3.Discipline and Structure:Chinese schools are known for their strict disciplineand well-structured curricula. This structured approach helps students develop good habits, time management skills, and a sense of responsibility.4.High Standards:The education system in China aims to maintain high standardsof academic excellence. This is reflected in the rigorous exams and assessments that students undergo, ensuring they are constantly challenged and pushed to excel.Challenges of Chinese Education:1.Heavy Focus on Exams:While exams serve as a metric to evaluate studentperformance, the overemphasis on them can lead to a narrow focus on exam-related content, neglecting other important areas of education like creativity, critical thinking, and practical skills.ck of Diversity:The one-size-fits-all approach to education in China can limitthe opportunities for students to explore their interests and talents.The standardized curriculum and exams do not always cater to the diverse needs and abilities of students.3.Stress and Burnout:The intense focus on exams and high standards can createimmense pressure on students, leading to stress, anxiety, and even burnout.This can have negative impacts on their mental health and well-being.4.Limited Autonomy:The strict structure and discipline in Chinese schools cansometimes limit students' autonomy and agency. Students may feel constrained in terms of exploring their own interests and taking initiative in their learning.In conclusion,while the Chinese education system has several strengths that prepare students well for academic and professional success, it also faces some challenges that need to be addressed. Balancing the focus on fundamentals with the promotion of creativity and diversity,as well as prioritizing student well-being,are crucial in creating a more comprehensive and inclusive education system.。

初始计量英语

初始计量英语

IntroductionIn the globalized landscape where competition is fierce and quality standards are continuously escalating, understanding the multi-dimensional aspects of high-quality and high-standard metrics becomes paramount. These metrics are not just numerical indicators; they embody a comprehensive framework that reflects excellence in various domains, including but not limited to manufacturing processes, service delivery, product design, education, and policy implementation. This essay aims to delve into the intricacies of high-quality and high-standard metrics from multiple perspectives.First Dimension: Precision and AccuracyHigh-quality and high-standard metrics often begin with precision and accuracy. In any field, whether it's scientific research or industrial production, these terms represent the degree to which measurements or outcomes correspond to their true values. Precision refers to the consistency of repeated measurements while accuracy concerns how close those measurements are to the actual value. For instance, in manufacturing, high-quality products adhere strictly to precise specifications and tolerances, ensuring consistent performance and longevity. Similarly, in academic research, studies that employ highly accurate and precise data collection methods contribute significantly to the validity and reliability of results.Second Dimension: Efficiency and EffectivenessAnother critical aspect of high-quality and high-standard metrics involves efficiency and effectiveness. Efficiency pertains to achieving maximum output with minimum input, whereas effectiveness is about doing the right things to achieve intended goals. A high-quality service, for example, might be one that minimizes customer wait times (efficiency) while maximizing customer satisfaction (effectiveness). In project management, a high-standard metric could be measured by the timely completion of milestones within budget, coupled with meeting or exceeding client expectations.Third Dimension: Adaptability and InnovationIn today's fast-paced world, adaptability and innovation have become key components of high-quality and high-standard metrics. An adaptable system can respond effectively to change and improve over time, while innovative approaches lead to breakthroughs and competitive advantages. High-quality software development, for instance, demands not only error-free coding but also the ability to integrate new features and updates quickly. Educational institutions that foster innovation and adaptability in their curriculum design and teaching methodologies can ensure that students are equipped with skills relevant to a rapidly evolving job market.Fourth Dimension: Sustainability and ResponsibilityA fourth dimension in assessing high-quality and high-standard metrics is sustainability and responsibility. Products, services, and policies should meet present needs without compromising future generations' ability to meet theirs. This includes environmental stewardship, social equity, and economic viability. For example, a construction company adhering to high-quality standards may use eco-friendly materials and efficient energy systems, thereby reducing its carbon footprint. Similarly, corporate governance practices that incorporate ethical decision-making and social responsibility form part of high-standard business operations.Fifth Dimension: User Experience and Customer SatisfactionLastly, user experience and customer satisfaction are pivotal dimensions in defining high-quality and high-standard metrics. A superior product or service must offer an intuitive, seamless, and enjoyable experience to users, alongside fulfilling their requirements. The measurement of customer satisfaction through feedback mechanisms, surveys, and reviews provides valuable insights into areas that need improvement and serves as a testament to the quality of the offering.ConclusionIn summary, high-quality and high-standard metrics encompass a broad spectrum of characteristics that transcend mere technical specifications orquantitative assessments. They require a holistic approach that takes into account precision and accuracy, efficiency and effectiveness, adaptability and innovation, sustainability and responsibility, and user experience and customer satisfaction. By rigorously applying these multi-faceted metrics across all sectors and industries, organizations can not only maintain but also enhance their competitive edge and foster a culture of continuous improvement and excellence. This underscores the importance of developing and maintaining high-quality and high-standard benchmarks in every facet of human endeavor.While this analysis has touched upon several core elements, it's essential to note that the definition and application of high-quality and high-standard metrics can vary widely depending on the specific context and industry. Regardless, the pursuit of these metrics remains a cornerstone for progress and success in the 21st century.Word count: 649 words (excluding title)。

名词解释(谢哲宇修改

名词解释(谢哲宇修改

Chapter 1Statistics(统计学):研究数据资料的收集、整理、分析和解释(interpretation)的科学。

Biostatistics(生物统计学):统计学应用于生物科学Variable(变量):指某种特征,它的表现在不同个体间或不同组间存在变异性。

Observation(观测值):指对变量的表现进行观察或测量所获得的数值,有时也被称为变数(variate)Population(总体):又叫“统计总体”,是指一个统计问题研究对象的全体,它是具有某种(或某些)共同特征的元素的集合。

Individual(个体):总体中每一个研究对象称作个体。

Sample(样本):从总体中按一定方法抽取部分具有代表性的个体,这部分个体称为样本。

Parameter(参数):描述总体特征的数,如总体平均数、总体方差等。

Statistic(统计量):描述样本特征的量,如样本平均数、样本方差、样本相关系数等。

Accuracy(准确性):指观测值或估计值与真值的接近程度。

Precision(精确性):对同一物体的重复观察值或估计值彼此之间的接近程度。

Chapter 2Raw data(直接数据):数据调查与实验未经处理的数据;Continuous data(连续性数据):指在一定范围内可取任何实数值的数据。

Discrete data(离散性数据):在一定范围内只能取有限种可能值的数据。

Count data(计数数据):用计数的方式得到的数据资料,必须用整数来表示。

Classification data(分类资料):可自然的或人为的分为2个或多个不同类别的资料。

例如:男生记做1 女生记做2频数(率)分布(frequency distribution);;下四分位数(lower quartile);中位数(median);上四分位数(upper quartile);条形图(bar chart);直方图(histogram);饼图(pie chart);散点图(scatter plot),组间距(interval)Percentile(百分位数):一组n个观测值按数值大小排列,小于某数值的数据个数占全体个数的x%,则为x%分位数。

上大学的重要性英语作文

上大学的重要性英语作文

Attending university is a significant milestone in an individuals life,offering a multitude of benefits that extend beyond academic learning.Here are some key points that highlight the importance of pursuing higher education:1.Academic Excellence:Universities provide a comprehensive curriculum that allows students to delve deeper into their chosen field of study.This academic depth is crucial for understanding complex concepts and theories that form the foundation of various professions.2.Skill Development:Beyond the classroom,universities offer opportunities to develop a range of skills.These include critical thinking,problemsolving,communication,and teamwork,which are essential for success in the workplace and in life.working Opportunities:University life exposes students to a diverse community of individuals from different backgrounds and cultures.This environment is conducive to building a professional network that can be invaluable for future career opportunities.4.Research and Innovation:Universities are hubs for research and innovation.Students have the opportunity to participate in cuttingedge research projects,which can lead to groundbreaking discoveries and advancements in various fields.5.Personal Growth:Living away from home and managing ones own affairs can significantly contribute to personal growth.University life encourages independence, selfreliance,and maturity.6.Career Preparation:A university degree is often a prerequisite for many professional careers.Higher education equips students with the necessary qualifications and credentials that employers seek.7.Cultural Exposure:Universities often host cultural events,guest lectures,and international exchange programs,providing students with a broader understanding of the world and its diverse cultures.8.Access to Resources:Universities provide access to stateoftheart facilities,including libraries,laboratories,and technological resources that are essential for academic and research pursuits.9.Career Services:Most universities have dedicated career services that assist students in finding internships,parttime jobs,and fulltime employment upon graduation,easing the transition from academia to the professional world.10.Lifelong Learning:The habit of lifelong learning is often instilled during university years.This mindset is crucial in todays rapidly changing world,where continuous learning is necessary to stay relevant and competitive.In conclusion,attending university is not just about obtaining a degree it is a transformative experience that shapes an individuals intellectual,professional,and personal development.It opens doors to a world of opportunities and equips students with the tools necessary to navigate and succeed in an everevolving global landscape.。

非酒精性脂肪性肝病高危人群监测与防治

非酒精性脂肪性肝病高危人群监测与防治

∗基金项目:科技部病毒性肝炎及艾滋病等传染病重大专项(编号:2018ZX10723203);珠江人才计划本土创新团队项目(编号: 2017BT01S131)作者单位:511340广州市南方医科大学南方医院增城分院(李俊缨,陈金军);南方医院(周玲)第一作者:李俊缨:女,27岁,南方医科大学传染病学硕士㊂主要从事非酒精性脂肪性肝病诊断和微创减重手术治疗临床研究㊂E-mail:2292921780@通讯作者:陈金军,E-mail:chjj@ ㊃专家论坛㊃非酒精性脂肪性肝病高危人群:监测与防治∗李俊缨,周玲,陈金军㊀㊀ʌ关键词ɔ㊀非酒精性脂肪性肝病;高危人群;防治㊀㊀DOI:10.3969/j.issn.1672-5069.2020.05.002㊀㊀Surveillance and management of individuals with high risk of NAFLD㊀Li Junying,Zhou Ling,Chen Jinjun.Department of Liver Diseases,Zengcheng Branch,Nanfang Hospital,Guangzhou510515,Guangdong Province,China㊀㊀ʌKey wordsɔ㊀Non-alcoholic fatty liver diseases;High risk;Surveillance and management㊀㊀非酒精性脂肪性肝病(NAFLD)已成为全球性最主要的肝病㊂儿童和成人可能有不同的发病机制,儿童更易受遗传和环境因素的影响㊂除基因外,高龄㊁男性或绝经期女性㊁2型糖尿病㊁肥胖㊁饮酒和肌肉衰减为成人罹患NAFLD及疾病进展的高危因素㊂本文尝试总结成人NAFLD发病的高危因素及相应的监测和干预措施㊂1㊀主要高危因素1.1遗传易感性㊀多个层面的遗传异常影响单纯性非酒精性脂肪肝(NAFL)的罹患风险,以及疾病进展,包括非酒精性脂肪性肝炎(NASH)㊁肝纤维化㊁肝硬化和肝细胞癌,包括PNPLA3I148M突变增加NAFLD罹患及疾病进展(肝纤维化和肝细胞癌)的风险;TM6SF2E167K突变则是NAFLD更易发生肝病事件而心脑血管事件减少的 分流信号 [1]㊂在大队列真实世界研究中发现,NAFLD并不增加急性心肌梗死或中风的发病率[2]㊂以遗传特征将NAFLD 分层管理可能是将来个体化监测和干预NAFLD的方向㊂1.2老年与衰老㊀儿童和成人NAFLD的肝组织学特征和疾病早期表现不同,提示年龄的影响不仅是环境和遗传因素的积累,在发病机制上也不尽相同,需要更多的研究阐明㊂男性NAFLD的年龄分布呈U 型,即50~60岁开始下降[3]㊂绝经前妇女则罹患NAFLD较少,绝经后增加明显;绝经期女性需要更多的关注㊂1.3肥胖㊀肥胖是重要的代谢异常组分,与罹患NAFLD密切相关㊂重复肝脏活检的队列研究证实,肥胖是NAFLD肝纤维化快速进展的危险因素[4]㊂超重,尤其是肥胖是NAFLD相关肝细胞癌发生的独立危险因素,男性肥胖患者患病风险更高㊂非肥胖者罹患NAFLD的高危因素包括中心性肥胖㊁胰岛素抵抗㊁体质量快速增加和遗传危险因素,例如PNPLA3多态性㊂关于肥胖NAFLD人群的研究较多,而非肥胖型NAFLD已经受到了重视[5]㊂肥胖,或者是内脏肥胖时的炎症细胞,尤其是巨噬细胞,在脂肪组织和肝组织中的功能表型转化㊁细胞迁移和信号传递可能在肥胖导致的NAFLD进展过程中起重要作用[6]㊂1.42型糖尿病(T2DM)㊀我国T2DM的流行率持续升高,其合并的NAFLD问题日渐突出㊂T2DM也是NAFLD肝纤维化快速进展的独立危险因素[4]㊂以无创筛查手段发现T2DM患者中进展性肝纤维化比例>10%,50%左右NAFLD相关肝硬化患者合并2型糖尿病㊂胰岛素抵抗和高胰岛素血症是两者的共同疾病基础㊂部分治疗2型糖尿病的药物可缓解NAFLD相关的肝脏问题,包括肝脏脂肪变性㊁炎症,甚至肝纤维化[7]㊂有关处置糖尿病的专业群体,包括但不限于医疗㊁护理㊁诊断㊁康复等人员,应高度重视2型糖尿病的肝脏并发症,即NAFLD及其肝病疾病谱㊂1.5饮酒㊀虽然临床诊断的标准和流程会将酒精性㊃216㊃实用肝脏病杂志2020年9月第23卷第5期㊀J Prac Hepatol,Septemper.2020.Vol.23No.5肝病与NAFLD鉴别开,但两者常常同时存在,尤其是肥胖患者㊂饮酒是NAFLD进展为NASH的危险因素㊂空腹中等饮酒量也可使得肥胖相关肝脏脂肪变性进展为脂肪性肝炎㊂最近的前瞻性研究证实,NAFLD患者即便非过量饮酒也会导致NAFLD肝纤维化进展㊂在NAFLD患者中,没有安全的饮酒量[8]㊂酒精性肝病与NAFLD在细胞等多个层面上具有共同的发病机制,可能都有乙醇的作用,其差别在于乙醇的来源㊂阐明肠道微生态相关的内源性乙醇的产生机制有助于制定两种不同临床表型的肝脏疾病的监测和干预策略㊂1.6肌肉衰减㊀肌肉衰减与年龄㊁饮食㊁运动和遗传相关㊂一般是由于年龄增长和衰老所致,而在年轻人群中运动和饮食是肌肉衰减的主要影响因素㊂大规模的队列研究大部分来自韩国,其结果表明肌肉衰减与NAFLD发生率增高直接相关㊂肌肉衰减也是导致NAFLD患者肝内炎症㊁纤维化和长期病死率增高的风险因素[9,10]㊂1.7高危因素的相互作用㊀罹患NAFLD和疾病进展受遗传因素和环境因素的综合影响㊂具有多重高危因素的患者群体最需要关注㊂目前,多以遗传因素进行分组后进行互作分析㊂较新的研究数据提示,胰岛素抵抗或高胰岛素血症加重具有遗传易感性群体的肝脂肪变[11],而年龄相关的肌肉衰减并不会恶化PNPLA3I148M携带者肝脂肪变或肝纤维化的级别[12]㊂最新的尝试发现,可将NAFLD分为遗传型(genetic NAFLD)和代谢型(metabolic NAFLD),更有助于理解常见高危因素与NAFLD的相互因果关系㊂很多队列研究采用多因素综合分析法㊂在单纯肝脏脂肪变转变为NASH的高危因素上,短期内(6个月内)体质量增加超过5kg,体质指数㊁胰岛素抵抗评分㊁血胆固醇㊁甘油三酯㊁瘦素水平升高的人群更容易使得NAFL进展为NASH[13]㊂队列研究证实,高龄㊁肥胖㊁T2DM㊁PNPLA3和rs738409SNP基因是NASH相关肝纤维化进展的独立危险因素[14]㊂重复肝脏活检的队列研究证实,T2DM和肥胖是NAFLD肝纤维化快速进展的独立危险因素,也有队列研究证实,2型糖尿病和肥胖是NASH相关HCC 发病的危险因素[15]㊂2 高危人群的筛查与诊断结合部分高危因素,如肥胖人群和T2DM等重要高危因素的人口比例及部分发表数据,多国研究者利用数学模型推算,2016年我国大陆有2.43亿NAFLD人群,NAFLD相关肝硬化达110万,而2030年将分别达到3.14亿和230万[16]㊂针对NAFLD的相关医学筛查,定义高危人群并制定相关筛查和诊断策略,将最大程度地利用有限的医疗资源,发现和管理NAFLD,尤其是较易进展为脂肪性肝炎㊁进展性肝纤维化/肝硬化㊁肝细胞癌的人群,可以做到早发现㊁早干预,降低未来我国肝病负担,将是健康中国的重要部分㊂针对NAFLD人群的筛查,采用简便㊁易行㊁低价㊁敏感㊁无创方法和手段进行比较适宜㊂关于肝脏脂肪变性的筛查和诊断手段,常用腹部超声,已发表的大部分NAFLD流行率的横断面数据也是采用腹部超声检查㊂考虑到操作简便性和可靠性,未来将会普及使用肝脏瞬时弹性成像的脂肪衰减等技术㊂目前,已有不少类似设备上市,但各设备诊断界值各异,需要进一步确认㊂磁共振脂肪定量成像(MRI-PDFF)可用于NAFL和NASH的肝脏脂肪含量的定性和定量诊断[17],但部分极高体质量者无法进行相关的检查和诊断㊂建议对超重或肥胖及T2DM患者进行常规筛查肝脏脂肪变性,尤其是绝经期妇女㊁老年且出现肌肉衰减者等亚群体㊂脂肪性肝炎的筛查主要依赖谷丙转氨酶的反复测量㊂目前,尚缺乏更佳的血清生物标记物准确筛查NASH,需要更多研究㊂建议针对肥胖或超重㊁T2DM等人群定期检测谷丙转氨酶(3~6个月),尤其是体质量迅速增加(5kg/6个月)㊁饮酒㊁肌肉衰减等高危群体㊂肝脏纤维化程度是影响NAFLD发生临床显性肝病事件的最主要的决定因素,筛查NAFLD高危人群肝纤维化更重要㊂针对NASH肝纤维化相关生物标志物较多,包括透明质酸㊁IV型7S胶原㊁III前胶原肽和花紫藤凝集素阳性mac2结合蛋白(WFA-M2BP)㊂血小板计数是预测NAFLD患者晚期肝纤维化最简单的指标㊂欧洲多个相关协会的联合指导意见建议对合并肥胖或任何代谢综合征(MS)的患者应该接受超声和脂肪变性生物标记和血清肝酶水平检查,以鉴别诊断NAFL和NASH[18]㊂所有NAFLD患者均需进行肝脏纤维化程度的评估㊂NASH相关肝硬化病例逐渐增多,但大部分肝病相关专业医疗人员仍然未对其给予足够的重视,尤其是在与隐源性肝硬化的鉴别诊断的情形下㊂NASH肝硬化的诊断主要元素包括:病史上有肝脏脂肪变性,或者至少1个异常组分;肝组织学或其他影像学证实存在肝硬化或者门静脉高压等证据,初步排除常见慢性肝病病因,如病毒性肝炎㊁酒精性肝㊃316㊃实用肝脏病杂志2020年9月第23卷第5期㊀J Prac Hepatol,Septemper.2020.Vol.23No.5病㊁自身免疫性肝病㊁肝豆状核变性等,即可初步诊断[19]㊂建议按照代谢性脂肪性肝病的概念重新审视NASH相关肝硬化的诊断流程,尤其是在隐源性肝硬化的鉴别诊断㊂NASH肝硬化患者需要筛查门静脉高压的相关高危临床事件风险,胃食管静脉曲张㊁腹水㊁HCC等㊂针对NASH相关HCC,筛查以甲胎蛋白和腹部超声为基础,以每6个月进行筛查㊂但近期研究证实甲胎蛋白缺乏有效监测的特异性和灵敏性㊂HCC的诊断以影像学和组织学为证据[20]㊂肝脏病理是诊断NAFLD的 金标准 ㊂在成人型NASH(1型),炎症和胶原沉积发生在肝小叶3区窦状旁窦,并与小叶炎症㊁肝细胞气球样变和马洛里小体相关,而儿童型NASH(2型)表现为1区炎症㊁主要是门脉-窦周纤维化而缺乏明显的气球样变㊂很大比例的儿童患者具有1型和2型NASH的重叠特征[21]㊂3 干预治疗3.1生活方式干预㊀生活方式干预是治疗NAFLD的一线和基础性治疗㊂针对NAFLD而言,体质量减少5%可以减少肝脂肪变性,减重10%可改善肝坏死炎症和纤维化[22]㊂但临床实践常忽略的问题是,生活方式干预有效率较低,超过70%患者并不能达到减重的目的,需要更多的手段,包括严密的生活方式监督㊁改善认知和行为模式等综合运用㊂3.2药物治疗㊀目前,尚无国家管理部门批准用于NAFLD的治疗药物[23]㊂针对NAFL患者,初步证据表明胰高血糖素样肽-1激动剂,如依塞那肽和利拉格肽,能改善肝脂肪变性,但减轻体质量的效果不明确[24]㊂针对NASH患者,多个队列研究均证实维生素E㊁吡格列酮㊁胆汁酸衍生物6-乙基和Resmetirom 是对经组织学证实的NASH患者短期内最有效的药物㊂依折麦布作为降低肠道胆固醇摄取的降脂药可改善NAFLD的肝组织学损伤[23]㊂针对NASH相关肝硬化,肾素血管紧张素醛固酮系统抑制剂被证实能改善肝纤维化程度[23]㊂针对NASH相关HCC,研究证实对合并T2DM的NASH相关早期肝硬化患者长期使用二甲双胍显著降低了失代偿肝硬化和HCC 的发生㊁发展及死亡[25]㊂他汀类药物的使用可能与HCC的风险降低有关[26]㊂3.3减肥手术㊀有效的减肥手术将显著改善/逆转NAFLD的所有肝组织学特征,特别是包括严重肥胖患者的纤维化㊂针对病态肥胖NASH早期肝硬化患者,研究证实胃袖状切除术除了减重之外可逆转肝硬化[27]㊂胃左动脉栓塞术也开始用于肥胖患者的减重治疗,但目前对于NAFLD治疗效果尚不明确㊂ʌ参考文献ɔ[1]CarlssonB,Lindén D,Brolén G,et al.The emerging role of genet-ics in precision medicine for patients with non-alcoholic steatohepa-titis.Aliment Pharmacol Ther,2020,51(12):1305-1320. [2]AlexanderM,Loomis AK,Lei J,et al.Non-alcoholic fatty liverdisease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of18million European adults.BMJ,2019,367:l5367.[3]Lonardo A,Bellentani S,KArgo C,et al.Epidemiologicalmodifiers of non-alcoholic fatty liver disease:focus on high-risk groups.Dig Liver Dis,2015,47(12):997-1006.[4]Singh S,Allen AM,Wang Z,et al.Fibrosis progression in nonal-coholic fatty liver vs nonalcoholic steatohepatitis:a systematic review and meta-analysis of paired-biopsy studies.Clin Gastroen-terol Hepatol,2015,13(4):643-654.[5]Cowman mentary on forensic and non-forensic psychiatricnursing skills and competencies for psychopathic and personality dis-ordered patients.J Clin Nurs,2014,23(7-8):1170-1171. [6]Lebeau PF,Byun JH,Platko K,et al.Pcsk9knockout exacerbatesdiet-induced non-alcoholic steatohepatitis,fibrosis and liver injury in mice.JHEP Rep,2019,1(6):418-429.[7]Younossi ZM,Golabi P,de Avila L,et al.The global epidemiologyof NAFLD and NASH in patients with type2diabetes:a systematic review and meta-analysis.J Hepatol,2019,71(4):793-801.[8]Chang Y,Cho YK,Kim Y,et al.Nonheavy drinking andworsening of noninvasive fibrosis markers in nonalcoholic fatty liver disease:a cohort study.Hepatology,2019,69(1):64-75. [9]Bhanji RA,Narayanan P,Allen AM,et al.Sarcopenia in hiding:the risk and consequence of underestimating muscle dysfunction in nonalcoholic steatohepatitis.Hepatology,2017,66(6):2055 -2065.[10]Kim JA,Choi KM.Sarcopenia and fatty liver disease.Hepatol Int,2019,13(6):674-687.[11]Barata L,Feitosa MF,Bielak LF,et al.Insulin resistance exacer-bates genetic predisposition to nonalcoholic fatty liver disease in in-dividuals without diabetes.Hepatol Commun,2019,3(7):894 -907.[12]Xia MF,Chen LY,Wu L,et al.The PNPLA3rs738409C>G va-riant influences the association between low skeletal muscle mass and NAFLD:The Shanghai Changfeng study.Aliment Pharmacol T-her,2019,50(6):684-695.[13]Zelber-Sagi S,Lotan R,Shlomai A,et al.Predictors for incidenceand remission of NAFLD in the general population during a seven-year prospective follow-up.J Hepatol,2012,56(5):1145-1151.[14]Koo BK,Joo SK,Kim D,et al.Additive effects of PNPLA3andTM6SF2on the histological severity of non-alcoholic fatty liver dis-ease.J Gastroenterol Hepatol,2018,33(6):1277-1285. [15]Turati F,Talamini R,Pelucchi C,et al.Metabolic syndrome andhepatocellular carcinoma risk.Br J Cancer,2013,108:222-228.㊃416㊃实用肝脏病杂志2020年9月第23卷第5期㊀J Prac Hepatol,Septemper.2020.Vol.23No.5㊀㊀∗基金项目:国家自然科学基金资助项目(编号:81870404/81670518/81170392)作者单位:510080广州市中山大学附属第一医院消化内科第一作者:叶俊钊,男,31岁,医学博士㊂主要从事非酒精性脂肪性肝病的基础和临床研究通讯作者:钟碧慧,E-mail:sophiazhong@[16]Estes C,Anstee QM,Arias-Loste MT,et al.Modeling NAFLDdisease burden in China,France,Germany,Italy,Japan,Spain, United Kingdom,and United States for theperiod2016-2030.J Hepatol,2018,69(4):896-904.[17]Hannah WN Jr,Harrison SA.Noninvasive imaging methods to de-termine severity of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.Hepatology,2016,64(6):2234-2243. [18]Yoneda M,Imajo K,Takahashi H,et al.Clinical strategy of diag-nosing and following patients with nonalcoholic fatty liver disease based on invasive and noninvasive methods.J Gastroenterol.2018, 53(2):181-196.[19]李俊缨,熊鸣,张继平,等.非酒精性脂肪性肝炎相关肝硬化的诊断和治疗进展.肝脏.2019,24(10):1008-1704. [20]Bruix J,Sherman M.Management of hepatocellular carcinoma:anupdate.Hepatology,2011,53:1020-1022.[21]Goldner D,Lavine JE.NAFLD in children:unique considerationsand challenges.Gastroenterology,2020,158(7):1967-1983.[22]Zelber-Sagi S,Lotan R,Shlomai A,et al.Predictors for incidenceand remission of NAFLD in the general population during a seven-year prospective follow-up.J Hepatol,2012,56:1145-1151.[23]Diehl AM,Day C.Cause,pathogenesis,and treatment of nonalco-holic steatohepatitis.N Engl J Med,2017,377(21):2063-2072.[24]Vilar-Gomez E,Calzadilla-Bertot L,Wai-Sun Wong V,et al.Type2diabetes and metformin use associate with outcomes of pa-tients with non-alcoholic steatohepatitis-related,Child-Pugh A cirrhosis.Clin Gastroenterol Hepatol,2020,S1542-3565(20) 30633-30639.[25]Margini C,Dufour JF.The story of HCC in NAFLD:from epidemi-ology,across pathogenesis,to prevention and treatment.Liver Int, 2016,36:317-324.[26]Wong VW,Chan RS,Wong GL,et munity-based lifestylemodification programme for non-alcoholic fatty liver disease:a ran-domized controlled trial.J Hepatol,2013,59:536-542. [27]Weiss CR,Abiola GO,Fischman AM,et al.Bariatric embolizationof arteries for the treatment of obesity(BEAT obesity)trial:results at1Year.Radiology,2019,291(3):792-800.(收稿:2020-07-06)(本文编辑:陈从新)㊃专家论坛㊃非酒精性脂肪性肝病合并代谢并发症患者规范治疗与管理∗叶俊钊,钟碧慧㊀㊀ʌ关键词ɔ㊀非酒精性脂肪性肝病;高血脂;高血糖;高尿酸;高血压;管理㊀㊀DOI:10.3969/j.issn.1672-5069.2020.05.003㊀㊀Standardized treatment and management ofpatients with metabolic complications and nonalcoholic fatty liver disease㊀Ye Junzhao,Zhong Bihui.Department of Gastroenterology,First Affiliated Hospital,Sun Yat-sen University,Guangzhou510080, Guangdong Provinnce,China㊀㊀非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD),现有更名为代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)[1],是我国乃至世界最主要的慢性肝脏疾病,累及超过全球26%以上的总人口[2,3]㊂大数据显示MAFLD 患病率仍处于持续上升阶段,并且年轻化㊁大众化趋势日益显著[3]㊂MAFLD不仅导致肝脏炎症㊁肝硬化和肝癌[2],还与糖脂代谢紊乱互为因果,引发一系列代谢合并症,包括高血糖㊁高尿酸㊁高血压和高血脂等[4],而这些合并症是驱动2型糖尿病㊁痛风和动脉粥样硬化性心脑血管疾病发生的高危因素,为患者和社会带来了巨大的负担[2]㊂纠正MAFLD合并的代谢异常对于疾病控制和降低远期严重并发症极其关键,但由于其涉及的代谢合并症多且往往相互重叠,如何针对性选用兼顾不同合并症情况下的最佳治疗,往往需要临床医师综合参照多个专科指南才㊃516㊃实用肝脏病杂志2020年9月第23卷第5期㊀J Prac Hepatol,Septemper.2020.Vol.23No.5。

计量经济学英汉术语名词对照及解释

计量经济学英汉术语名词对照及解释

计量经济学英汉术语名词对照及解释A校正R2(Adjusted R-Squared):多元回归分析中拟合优度的量度,在估计误差的方差时对添加的解释变量用一个自由度来调整。

对立假设(Alternative Hypothesis):检验虚拟假设时的相对假设。

AR(1)序列相关(AR(1) Serial Correlation):时间序列回归模型中的误差遵循AR (1)模型。

渐近置信区间(Asymptotic Confidence Interval):大样本容量下近似成立的置信区间。

渐近正态性(Asymptotic Normality):适当正态化后样本分布收敛到标准正态分布的估计量。

渐近性质(Asymptotic Properties):当样本容量无限增长时适用的估计量和检验统计量性质。

渐近标准误(Asymptotic Standard Error):大样本下生效的标准误。

渐近t 统计量(Asymptotic t Statistic):大样本下近似服从标准正态分布的t统计量。

渐近方差(Asymptotic Variance):为了获得渐近标准正态分布,我们必须用以除估计量的平方值。

渐近有效(Asymptotically Effcient):对于服从渐近正态分布的一致性估计量,有最小渐近方差的估计量。

渐近不相关(Asymptotically Uncorrelated):时间序列过程中,随着两个时点上的随机变量的时间间隔增加,它们之间的相关趋于零。

衰减偏误(Attenuation Bias):总是朝向零的估计量偏误,因而有衰减偏误的估计量的期望值小于参数的绝对值。

自回归条件异方差性(Autoregressive Conditional Heteroskedasticity, ARCH):动态异方差性模型,即给定过去信息,误差项的方差线性依赖于过去的误差的平方。

一阶自回归过程[AR(1)](Autoregressive Process of Order One [AR(1)]):一个时间序列模型,其当前值线性依赖于最近的值加上一个无法预测的扰动。

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x∈F∗ q
(x ∈ Fq )
χ(x)λ(x) ∈ Z [ζp(q−1) ]. 2
Lemma 2.1: (1) (trivial cases) q − 1, if χ = 1(= ψ 0 ) and λ = 1(= λ0 ) G(χ, λ) = Gq (χ, λ) = −1, if χ = 1 and λ = 1 0, if χ = 1 and λ = 1. (2) For b ∈ F∗ q (namely, λb = 1) G(χ, λb ) = χ(b)G(χ), G(χ) = χ(−1)G(χ), where χ is the conjugate character of χ and G(χ) = G(χ, λ1 ) =
2Hale Waihona Puke 2.1Preliminaries
Gauss sums
We introduce several basic facts on Gauss sums used in this paper. For more details on Gauss sums we refer the book [3]. Let q = pl where p is a prime number and l ≥ 1, θ be a primitive element of the √ 2π −1 ∗ finite field Fq , namely Fq = θ . Let ζm = e m for any positive integer m. The group of additive characters of Fq is ˆq = {λb : b ∈ Fq }, F where
(3) If χ = 1, then
Lemma 2.3: (semiprimitive case, [3, Theorem 11.6.3]) Let p be a prime number, e ≥ 3. Suppose that there exists a positive integer t such that pt ≡ −1 (mod e). Let t be the smallest positive integer satisfying pt ≡ −1 (mod e)(so that the multiplicative ∗ order of p in Ze is 2t). For l = 2ts (s ≥ 1), q = pl and a multiplicative character χ of Fq with order e, we have Gq (χ) = √ √ q (−1)s−1 , q (−1) if p = 2
[22,24]) and the weight hierarchy is totally determined in several cases. The bounds, asymptotic behaviour and duality of GHWs have been found [1,11,17,20,23]. But in general speaking, to determine the weight hierarchy is a difficult problem. In this paper we deal with GHWs of q -ary irreducible cyclic codes. For binary case (q = 2) there exist several results in [14,20,21]. We consider the general case where q is any power of a prime number. We firstly present two general formulas on dr (C ) ((3.3) and (3.4) in Theorem 3.2) which involves Gauss sums and character sum β ∈H \{0} ϕ(β ), where ϕ is a multiplicative character of FQ (Q = q k ) and H is a Fq -subspace of FQ with dimension r or k − r . When involved Gauss sums can be calculated and have the same values, the character sum is reduced to be the size of ′ ′ H θe , where θe is a subgroup of F∗ Q = θ . Then we can determine dr (C ) for smaller r by (3.3) and larger r by (3.4). And the weight hierarch {dr (C ) : 1 ≤ r ≤ k } can be totally determined in several cases. The paper is organized as follows. In Section 2 we introduce several basic facts on Gauss sums and previously known results on GHWs. Then we present two general formulas on dr (C ) and their direct consequences in Section 3. In Section 4 we obtain more results on dr (C ) for several particular cases. Section 5 is conclusion.
T (bx) λb (x) = ζp
and T is the trace mapping from Fq to Fp . The group of multiplicative characters of Fq is ˆ∗ = {ψ i : 0 ≤ i ≤ q − 2} = ψ F q where ψ is defined by ψ (θ) = ζq−1. ˆ∗ and λ ∈ F ˆq we define the Gauss sum on Fq by For each χ ∈ F q G(χ, λ) =
Generalized Hamming Weights of Irreducible Cyclic Codes
Minghui Yang, Jin Li, Keqin Feng, Dongdai Lin
arXiv:1410.2702v1 [cs.IT] 10 Oct 2014
Abstract-The generalized Hamming weight (GHW) dr (C ) of linear codes C is a natural generalization of the minimum Hamming distance d(C )(= d1 (C )) and has become one of important research objects in coding theory since Wei’s originary work [23] in 1991. In this paper two general formulas on dr (C ) for irreducible cyclic codes are presented by using Gauss sums and the weight hierarchy {d1 (C ), d2 (C ), . . . , dk (C )} (k = dim C ) are completely determined for several cases. keywords-generalized Hamming weight, irreducible cyclic code, Gauss sum.
q
and {d1 (C ), d2 (C ), . . . , dk (C )} is called the weight hierarchy of C (d0 (C ) = 0). It is obvious that d1 (C ) is just the minimun Hamming distance d(C ). The concept on GHW has appeared as early as in 1970’s ([12,17]) and has become an important research object in coding theory after Wei’s paper [23] in 1991, where Wei gives a series of beautiful results on GHW and indicates that it completely characterizes the performance of a linear code when it is used on wire-tap channel of type II which has connection with cryptography. GHW is also used to deal with t-resilient functions and trellis or branch complexity of linear codes [20]. In past two decades the value of GHWs has been determined or estimated for many series of linear codes (RM codes [10,23], BCH codes [4,8,9], trace codes [19], cyclic codes [6,16], AG codes [2,5,7,15,18,25,26], binary Kasami codes [13] and other codes 1
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