KPT-330_1393477-72-9_DataSheet_MedChemExpress
聚二甲基硅氧烷msds英文版
聚二甲基硅氧烷msds英文版以下是聚二甲基硅氧烷的MSDS（英文版）：Material Safety Data Sheet (MSDS)Product Na PolydimethylsiloxaneSection 1: Product and Company IdentificationProduct Na PolydimethylsiloxaneSynonyms: PDMS, Dimethicone, Silicone oilCAS No.: 63148-62-9Molecular Formula: (C2H6OSi)nManufacturer/Supplier: Beijing Haining Technology Co., LtdAddress: Room 101, Building A, No. 18 Shangdi Information Road, Haidian District, Beijing, ChinaTel: +86-10-12345678Fax: +86-10-12345678Email: info@hainingtechXXXSection 2: Composition/Information on IngredientsPolydimethylsiloxane is a polymer composed of repeating units of dimethylsiloxane. The molecular weight can vary from less than 1000 to more than 1 million. The following information pertains to a typical product with a molecular weight range of 10,000-100,000.Chemical Na PolydimethylsiloxaneCAS No.: 63148-62-9Molecular Weight: 10,000-100,000Percentages: >99%Section 3: Hazards IdentificationClassification:Not classified as hazardous according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).Potential Health Effects:Inhalation: May cause irritation of respiratory tract. Skin Contact: May cause mild irritation.Eye Contact: May cause eye irritation.Ingestion: Ingestion may cause gastrointestinalirritation or discomfort.Section 4: First Aid MeasuresInhalation: Move to fresh air. If symptoms persist, seek medical attention.Skin Contact: Remove contaminated clothing. Wash affected area with soap and water. If irritation persists, seek medical attention.Eye Contact: Rinse eyes thoroughly with water for at least15 minutes. If irritation persists, seek medical attention. Ingestion: Rinse mouth. Do not induce vomiting. Seek medical attention.Section 5: Fire Fighting MeasuresFlammability:Polydimethylsiloxane is not flammable.Extinguishing Media:Use extinguishing media appropriate for surrounding fire. Fire Fighting Instructions:Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.Section 6: Accidental Release MeasuresSpill Cleanup:Contain spillage and prevent further leakage if possible. Absorb with inert material (e.g. sand, vermiculite). Scoop up and place in a suitable container for disposal.Section 7: Handling and StorageHandling:Avoid inhalation of vapors or mist. Avoid skin contact. Wear appropriate protective clothing and equipment.Storage:Store in a cool, dry, well-ventilated area away from directsunlight and sources of heat.Section 8: Exposure Controls/Personal ProtectionEngineering Controls:Provide adequate ventilation to maintain exposure levels below recommended limits.Personal Protective Equipment:Respiratory Protection: Not normally required.Hand Protection: Wear gloves when handling.Eye Protection: Wear safety glasses or goggles.Skin Protection: Wear appropriate protective clothing as needed.Section 9: Physical and Chemical PropertiesAppearance: Clear, colorless liquidOdor: OdorlessBoiling Point: >200°CMelting Point: <-50°CFlash Point: >300°CSolubility in Water: InsolubleSection 10: Stability and ReactivityStability:Polydimethylsiloxane is stable under normal conditions of use and storage.Reactivity:Polydimethylsiloxane does not react with most chemicals. Section 11: Toxicological InformationAcute Toxicity:LD50 (Oral, Rat): >5000 mg/kgSkin Irritation:Mild irritantEye Irritation:Mild irritantSection 12: Ecological InformationEnvironmental Fate:Polydimethylsiloxane is not expected to persist in the environment.Section 13: Disposal ConsiderationsDisposal Method:Dispose in accordance with all applicable local,state/provincial, and federal regulations.Section 14: Transportation InformationNot classified as hazardous for transportation.Section 15: Regulatory InformationRegulatory Status:Polydimethylsiloxane is listed on the TSCA inventory.Section 16: Other InformationThis MSDS conforms to OSHA Hazard Communication Standard 29 CFR 1910.1200. The information contained herein is based on the present state of our knowledge and is believed to be accurate. However, no warranty, express or implied, is made with respect to such information and we assume no liability resulting from its use.。
迈瑞铁蛋白检测试剂盒说明书
Manual ProcedureAutomated procedure on requestTest PrincipleFerric ions (Fe +3) are released from transferring under acidicconditions and reduced to ferrous state (Fe +2) by a strong reducing agent. Ferrous ions then react with Ferrozine to form a coloredcomplex which can be measured photometrically. The intensity of the color produced is proportional to the iron concentration in the sample. Lipemic samples are clarified by the detergent.Transferrin-Fe-complex apotransferrin + Fe 3+Fe 3+ Fe 2+Ferrozine + Fe 2+ colored complexStability and preparation of working reagentBuffer Reagent B-R1: liquid Powder Reagent P-R1: powder. Reagent R2: liquid, ready to useWorking ReagentAdd 10 ml reagent Buffer B-R1 to one vial powder reagent P-R1 andmix gently for 15 minutes before use.Stability: 2 weeks at 20 – 25 °C1 month at2 – 8 °CAll reagents are stable up to expiry date given on label when storedat 2 – 8 °CNote : All reagents should be clear solutions. Don’t use if the reagent is turbid. Specimen Collection and Handling1. Non-hemolyzed serum is the specimen of choice.2. Serum should be separated from blood clot as soon as possible.3. Heparinized plasma could only be used, other anticoagulantsshould not be used.4. Serum iron is reported to be stable for 4 days at 20 – 25°C and7 days at 2 – 8 °C.CalibratorMediCal U Cat. No. 15011Iron STD. Cat. No. 16131Quality controlMeditrol N Cat. No. 15171 Meditrol P Cat. No. 15181Iron (Ferrozine)Colorimetric testPowder liquid reagentsCalculationConc.Iron = ⨯ Conc. Standardμμ g /dlLinearity Up to 1000 μg/dl (179 μmol/L); If result exceeds 1000 μg/dl, repeat test using diluted sample (1+1) with sodium chloride solution (0.9 %) and multiply result by 2.Interference 1. Certain drugs and other substances are known to influencecirculating iron levels. 2. To make tubes, pipettes, etc. iron free, they must be washed with diluted (1+2) hydrochloric or nitric acid followed by several rinsings with iron free deionized or distilled water.Precautions 1. The reagent is toxi c, don’t pipette by mouth, avoid all contacts. 2. Use only disposable plastic containers or iron free tubes andcuvettes. Avoid any contamination by the use of clean laboratory material.Cat. No. 12881 B-R1 1 Buffer 50mlFor 50 testsP-R1 5 powder for 10 mlR2 1 x 10 ml(A S -A SB ) SampleA standardGuanidinium PH=4.5 Ascorbic acidIron ferrozine methodReference rangeReferences1. Garoc A., Clin. Chem. Acta 94, 115 (1979).2. Brivio et coll., La Ricerca Clin. Lab. 18, 523 (1986).3. Young, DS., Effects of Drugs on Clinical Laboratory Tests, fifthedition 2000, AACC Press, Washington, D.C.。
康派特医用胶临床应用
特别提示：喷胶时创面暂时干燥、用胶量少而薄。
腔镜应用
手术创面使用生理盐水冲洗后，明显出血点给予电凝止血，将盛有医 用胶的喷瓶与腔镜下用的长喷头紧密连接，从5mm的穿刺套管口送入 腹腔，对准创面或出血部位，距离创面约3cm，按压喷瓶喷洒出胶液 成均匀状覆盖在创面表面，几秒钟后即固化成膜，立即止血。
颅内动脉瘤和颈内动脉破裂止血：
肝脏切除术
粘合肝脏损伤创面 创面止血 防漏，减少胆漏发生
0-5级分级：1级反应
无致敏反应 •刺激指数（PII）：0 .8 视野内可见以中性白细胞 浸润为主的炎性反应，有 较多的胶原纤维和成熟的 纤维细胞，无异常反应 阴性
合格
合格 合格
植入
合格
遗传毒性
合格
1
2
3
产品介绍
临床应用
注意事项
创面血液、组织液中阴离子作用 下，快速聚合、固化成膜。胶膜 与创面镶嵌紧密，由直径２－３ μ m的纤维缠绕，呈网状结构， 胶膜与创面紧密镶嵌。牢固地保 持伤口的对合状态，其强度可达 ７Ｎ（牛顿) 网状结构可阻止血球、血小板 通过，，封闭创面断裂之小血 管网达到有效止血 胶膜将组织和细菌隔离，具抗 感染和护创作用 在表面形成胶膜，在脏器之间 形成物理隔断，起到防止粘连 作用，胶膜2-3月降解吸收
颅骨修补术：
翻开皮瓣后，将准备好的有机玻璃边缘涂胶后直接放在颅骨缺损处，与 周围的软组织粘合，必要时将边缘用7号丝线与软组织缝合，固定3点， 效果满意。
颅前凹低修补术：
取一块大小适当的颞骨，涂胶后置于颅底骨缺损处，然后再用涂胶的颞 肌粘堵在四周围，严密封闭。
颅脑损伤手术：
外伤性颅骨粉碎性骨折：进行颅骨修补术，将碎骨块用胶粘合固定或与 皮瓣粘合在一起缝合，这样粘合的颅骨瓣比较牢固，当遇到硬脑膜破损 不易缝合时，取颞肌筋膜与硬脑膜粘合在一起进行修补，或间断缝合帽 状腱膜后，皮瓣下涂胶，将其粘合于颅骨上。再缝合头皮，同样能防止
200种化学品理化特性表(83页)
200种化学品目录丙烯酸丁酯的理化及危险特性表 (1)丙烯酸的理化及危险特性表 (2)硝酸锌的理化及危险特性表 (3)过氧化二苯甲酰的理化及危险特性表 (4)过硫酸铵的理化及危险特性表 (5)丁酮的理化及危险特性表 (6)苯酚的主要理化和危险特性 (7)甲基叔丁基醚的主要理化及危险特性 (8)三聚氰酸的主要理化和危险特性 (9)季戊四醇的主要理化和危险特性 (10)硬脂醇的主要理化和危险特性 (11)多聚甲醛的主要理化和危险特性 (12)1，2-二甲苯的主要理化及危险特性 (13)1，3-二甲苯的主要理化及危险特性 (14)1，4-二甲苯的主要理化及危险特性 (15)环己烯的主要理化和危险特性 (16)二丁胺的主要理化和危险特性 (17)三乙胺的主要理化和危险特性 (18)甲基二氯硅烷的主要理化和危险特性 (19)异丁烯的主要理化和危险特性 (20)邻叔丁基苯酚的主要理化和危险特性 (21)对叔丁基苯酚的主要理化和危险特性 (22)环己烷的主要理化和危险特性 (23)二氯甲烷的主要理化和危险特性 (24)三氯甲烷的主要理化及危险特性 (25)硫脲的主要理化和危险特性 (26)六亚甲基四胺的主要理化和危险特性 (27)抗氧剂AT-10的主要理化和危险特性 (28)抗氧剂AT-76的主要理化和危险特性 (29)抗氧剂AT-3114的主要理化和危险特性 (30)催化剂JH-CMMS的主要理化和危险特性 (31)抗氧剂AT-168的主要理化和危险特性 (32)甲氧基钠的主要理化和危险特性 (33)氧气的理化及危险特性 (34)硝酸钾的理化及危险特性表 (35)硝酸钙的理化及危险特性表 (36)液氯的理化及危险特性 (37)盐酸的理化及危险特性 (38)丙酮理化及危险特性表 (39)次氯酸钠的理化及危险特性表 (40)二甲氧基甲烷的理化及危险特性表 (41)乙酸的理化及危险特性表 (42)香蕉水的理化及危险特性表 (43)甲醇的理化及危险特性表 (44)氰化亚铜的理化及危险特性 (45)硝酸的理化及危险特性 (46)硫酸的理化及危险特性 (47)铬酸的理化及危险特性 (48)铬酸酐的理化及危险特性 (49)氰化钠的理化及危险特性 (50)丁醇的理化及危险特性 (51)异丙醇的的理化及危险特性 (52)硝酸银的理化及危险特性表 (53)间戊二烯的理化及危险特性 (54)环戊二烯的理化及危险特性 (55)甲苯二异氰酸酯的理化及危险特性表 (56)200#溶剂油的理化及危险特性表 (57)聚氨酯漆固化剂理化及危险特性表 (58)聚氨酯漆稀释剂理化及危险特性表 (59)N，N--二甲基甲酰胺理化及危险特性 (60)丙烯腈理化及危险特性 (61)二氧化硫的特性 (62)异戊二烯的理化及危险特性 (63)醋酸丁酯的理化及危险特性 (64)醋酸乙酯的理化及危险特性 (65)甲苯的理化及危险特性 (66)环己酮的理化及危险特性 (67)三氯化铝(无水)的理化及危险特性 (68)氢氧化钠的理化及危险特性 (69)硝酸铅的理化及危险特性表 (70)电石理化及危险特性表 (71)乙炔理化及危险特性表 (72)氰化亚铜的理化及危险特性 (73)丙烯酸甲酯理化及危险特性................ 错误！未定义书签。
CHEMLOK 8110 商品安全数据表说明书
USA SAFETY DATA SHEET3000000013401. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONProduct name: CHEMLOK 8110 Product Use/Class:Aqueous AdhesiveLORD Corporation 111 LORD DriveCary, NC 27511-7923 USATelephone: 814 868-3180Non-Transportation Emergency: 814 763-2345 Chemtrec 24 Hr Transportation Emergency No.800 424-9300 (Outside Continental U.S. 703 527-3887)EFFECTIVE DATE: 08/21/20192. HAZARDS IDENTIFICATIONGHS CLASSIFICATION:Skin sensitization Category 1Reproductive toxicity Category 1BSpecific target organ systemic toxicity (single exposure) Category 1 Respiratory system, Systemic toxicity Specific target organ systemic toxicity (repeated exposure) Category 1 Aspiration hazard Category 1Hazardous to the aquatic environment - acute hazard Category 2 Hazardous to the aquatic environment - chronic hazard Category 2GHS LABEL ELEMENTS: Symbol(s)Signal WordD ANGERHazard StatementsMay cause an allergic skin reaction.May damage fertility or the unborn child.Causes damage to organs.(Respiratory system, Systemic toxicity) Causes damage to organs through prolonged or repeated exposure. May be fatal if swallowed and enters airways. Toxic to aquatic life.Toxic to aquatic life with long lasting effects.Precautionary Statements PreventionObtain special instructions before use.Do not handle until all safety precautions have been read and understood. Wear protective gloves.Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment.ResponseGet medical advice/attention if you feel unwell.IF exposed: Call a POISON CENTER or doctor/physician.Specific treatment (see supplemental first aid instructions on this label).IF ON SKIN: Wash with plenty of soap and water.If skin irritation or rash occurs: Get medical advice/attention.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.Do NOT induce vomiting.Wash contaminated clothing before reuse.Collect spillage.StorageStore locked up.Disposal:Dispose of contents/container in accordance with waste/disposal laws and regulations of your country or particular locality.Other Hazards:This product contains component(s) which have the following warnings; however based on the GHS classification criteria of your country or locale, the product mixture may be outside the respective category(s).Acute: Vapor harmful; may affect the brain or nervous system causing dizziness, headache or nausea. May cause central nervous system depression characterized by the following progressive steps: headache, dizziness, staggering gait, confusion, unconsciousness or coma. Possible irritation of the respiratory system can occur causing a variety of symptoms such as dryness of the throat, tightness of the chest, and shortness of breath. May cause skin and eyeirritation. May be harmful if swallowed. Ingestion is not an expected route of entry in industrial or commercial uses.Chronic: Prolonged or repeated contact may result in dermatitis. Repeated or prolonged solvent overexposure may result in permanent central nervous system damage. Formaldehyde may be released from this product in processes that involve heat. Formaldehyde is a skin and respiratory sensitizer, eye and throat irritant, and acute toxicant.Formaldehyde has been identified by NTP and IARC as a known human carcinogen (IARC 1), and by OSHA as a potential human carcinogen. Workplace exposure to formaldehyde is regulated by OSHA Standard 29 CFR1910.1048. IARC has designated carbon black as Group 2B - inadequate evidence for carcinogenicity in humans, but sufficient evidence in experimental animals. In 2006 IARC reaffirmed its 1995 finding that there is "inadequateevidence" from human health studies to assess whether carbon black causes cancer in humans. Further,epidemiological evidence from well-conducted investigations has shown no causative link between carbon black exposure and the risk of malignant or non-malignant respiratory disease in humans. IARC has designated titanium dioxide (TiO2) as Group 2B – possibly carcinogenic to humans in dust form. However, a number of long termanimal studies and human epidemiology studies evaluating TiO2 and workplace exposure show insufficient evidence for carcinogenic effects. EPA, NTP and OSHA do not designate TiO2 as a carcinogen and ACGIH designates TiO2 as A4 - not classifiable as a human carcinogen. Mortaility from other chronic diseases, including other respiratory diseases, was not associated with exposure to TiO2 dust. TiO2 is not present in this product as a dust and no airborne exposure is expected during application.3. COMPOSITION/INFORMATION ON INGREDIENTSChemical Name CAS Number RangeZinc compound PROPRIETARY 5 - 10%Carbon black1333-86-4 1 - 5%Propylene glycol monomethylether107-98-2 1 - 5%Nonylphenol ethoxylate compound PROPRIETARY0.1 - 0.9%Titanium dioxide13463-67-70.1 - 0.9%Resorcinol108-46-30.1 - 0.9%Any "PROPRIETARY" component(s) in the above table is considered trade secret, thus the specific chemical and its exact concentration is being withheld.The above Nonylphenol ethoxylate compound is listed by ECHA as an SVHC.4. FIRST AID MEASURESFIRST AID - EYE CONTACT: Flush eyes immediately with large amount of water for at least 15 minutes holding eyelids open while flushing. Get prompt medical attention.FIRST AID - SKIN CONTACT: Flush contaminated skin with large amounts of water while removing contaminated clothing. Wash affected skin areas with soap and water. Get medical attention if symptoms occur.FIRST AID - INHALATION: Move person to fresh air. Restore and support continued breathing. If breathing is difficult, give oxygen. Get immediate medical attention.FIRST AID - INGESTION: If swallowed, do not induce vomiting. Call a physician or poison control center immediately for further instructions. Never give anything by mouth if victim is rapidly losing consciousness, unconscious or convulsing.5. FIRE-FIGHTING MEASURESSUITABLE EXTINGUISHING MEDIA: Carbon Dioxide, Dry Chemical, Foam, Water FogUNSUITABLE EXTINGUISHING MEDIA: Not determined for this product.SPECIFIC HAZARDS POSSIBLY ARISING FROM THE CHEMICAL: Keep containers tightly closed. Closed containers may rupture when exposed to extreme heat. Use water spray to keep fire exposed containers cool. During a fire, irritating and/or toxic gases and particulate may be generated by thermal decomposition or combustion.SPECIAL PROTECTIVE EQUIPMENT AND PRECAUTIONS FOR FIRE-FIGHTERS: Wear full firefighting protective clothing, including self-contained breathing apparatus (SCBA). If water is used, fog nozzles are preferable.6. ACCIDENTAL RELEASE MEASURESPERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES: Avoid contact. Avoid breathing vapors. Use appropriate respiratory protection for large spills or spills in confined area.ENVIRONMENTAL PRECAUTIONS: Do not contaminate bodies of water, waterways, or ditches, with chemical or used container.METHODS AND MATERIALS FOR CONTAINMENT AND CLEANUP: Keep non-essential personnel a safe distance away from the spill area. Notify appropriate authorities if necessary. Avoid contact. Before attempting cleanup, refer to hazard caution information in other sections of the SDS form. Contain and remove with inert absorbent material.7. HANDLING AND STORAGEHANDLING: Keep closure tight and container upright to prevent leakage. Avoid skin and eye contact. Wash thoroughly after handling. Do not handle until all safety precautions have been read and understood. Empty containers should not be re-used. Use with adequate ventilation.STORAGE: Store only in well-ventilated areas. Keep from freezing. Keep container closed when not in use.INCOMPATIBILITY: Strong acids, bases, and strong oxidizers.8. EXPOSURE CONTROLS/PERSONAL PROTECTIONCOMPONENT EXPOSURE LIMITChemical Name ACGIH TLV-TWA ACGIH TLV-STELOSHA PEL-TWAOSHA PEL-CEILINGSkinZinc compound 2 mg/m310 mg/m3 5 mg/m3 N.E.N.A.Carbon black 3 mg/m3N.E. 3.5 mg/m3 N.E.N.A. Propylene glycolmonomethylether100 ppm150 ppm N.E. N.E.N.A.Nonylphenol ethoxylatecompoundN.E.N.E.N.E. N.E.N.A.Titanium dioxide10 mg/m3N.E.15 mg/m3 N.E.N.A.Resorcinol10 ppm20 ppm N.E. N.E.N.A.N.A. - Not Applicable, N.E. - Not Established, S - Skin DesignationEngineering controls: Sufficient ventilation in pattern and volume should be provided in order to maintain air contaminant levels below recommended exposure limits.PERSONAL PROTECTION MEASURES/EQUIPMENT:RESPIRATORY PROTECTION: Use a NIOSH approved chemical/mechanical filter respirator designed toremove a combination of particulates and organic vapor if occupational limits are exceeded. For emergencysituations, confined space use, or other conditions where exposure limits may be greatly exceeded, use an approved air-supplied respirator. For respirator use observe OSHA regulations (29CFR 1910.134) or use in accordance with applicable laws and regulations of your country or particular locality. Note: If the exposure limit for formaldehyde is exceeded, a formaldehyde-specific, formaldehyde/organic vapor combination, or airline respirator may be required.SKIN PROTECTION: Use neoprene, nitrile, or rubber gloves to prevent skin contact.EYE PROTECTION: Use safety eyewear including safety glasses with side shields and chemical goggles where splashing may occur.OTHER PROTECTIVE EQUIPMENT: Remove and wash contaminated clothing before reuse.HYGIENIC PRACTICES: Wash hands before eating, smoking, or using toilet facility. Do not smoke in anychemical handling or storage area. Food or beverages should not be consumed anywhere this product is handled or stored. Wash thoroughly after handling.9. PHYSICAL AND CHEMICAL PROPERTIESTypical values, not to be used for specification purposes.ODOR: Mild VAPOR PRESSURE: N.D.APPEARANCE: Gray VAPOR DENSITY: Heavier than Air PHYSICAL STATE: Liquid LOWER EXPLOSIVE LIMIT: 1.6 %(V)FLASH POINT:≥ 201 °F, 93 °CUPPER EXPLOSIVE LIMIT: 13.8 %(V)Setaflash Closed CupBOILING RANGE: 100 - 120 °C EVAPORATION RATE: Slower than n-butyl-acetate AUTOIGNITION TEMPERATURE:N.D.DENSITY: 1.16 g/cm3 - 9.67 lb/gal DECOMPOSITION TEMPERATURE:N.D. VISCOSITY, DYNAMIC: ≥20 mPa.s @ 25 °C ODOR THRESHOLD: N.D.VISCOSITY, KINEMATIC: ≥17 mm2/s @ 25 °CSOLUBILITY IN H2O: Water Dispersible VOLATILE BY WEIGHT: 64.55 %pH: 6.5VOLATILE BY VOLUME: 75.28 %FREEZE POINT: 32 F VOC CALCULATED: 1.23 lb/gal, 148 g/l COEFFICIENT OF WATER/OILN.D. METHOD 24: 1.70 lb/gallonDISTRIBUTION:LEGEND: N.A. - Not Applicable, N.E. - Not Established, N.D. - Not Determined10. STABILITY AND REACTIVITYHAZARDOUS POLYMERIZATION: Hazardous polymerization will not occur under normal conditions. STABILITY: Product is stable under normal storage conditions.CONDITIONS TO AVOID: High temperatures. Sources of ignition.INCOMPATIBILITY: Strong acids, bases, and strong oxidizers.HAZARDOUS DECOMPOSITION PRODUCTS: May contain CO, CO2, oxides of nitrogen, oxides of sulfur, halogenated by-products, Metal oxides11. TOXICOLOGICAL INFORMATIONEXPOSURE PATH: Refer to section 2 of this SDS.SYMPTOMS:Refer to section 2 of this SDS.TOXICITY MEASURES:Chemical Name LD50/LC50Zinc compound Oral LD50: Rat> 5,000 mg/kgGHS LC50 (vapour): Acute toxicity point estimate55 mg/l Carbon black Oral LD50: Rat> 15,400 mg/kgDermal LD50: Rabbit> 3 g/kgGHS LC50 (vapour): Acute toxicity point estimate55 mg/l Propylene glycol monomethylether Oral LD50: Rat5,000 mg/kgDermal LD50: Rabbit13 g/kgGHS LC50 (vapour): Acute toxicity point estimate11 mg/l GHS LC50(dust and mist): Acute toxicity point estimate1.5 mg/l Inhalation LC50:Rat>7559 ppm/6 hNonylphenol ethoxylate compound N.D.Titanium dioxide Oral LD50: Rat> 10,000 mg/kgDermal LD50: rabbit> 5,000 mg/kgGHS LC50 (vapour): Acute toxicity point estimate55 mg/l Resorcinol Oral LD50: Rat202 mg/kgDermal LD50: Rabbit3,360 mg/kgInhalation LC50: Rat21.3 mg/l/1 hGerm cell mutagenicity: No classification proposedCarcinogenicity: No classification proposedReproductive toxicity: Category 1B - May damage fertility or the unborn child.Components contributing to classification: Methanol.12. ECOLOGICAL INFORMATIONECOTOXICITY:Chemical Name EcotoxicityZinc compound N.D.Carbon black N.D.Propylene glycol monomethylether Fish: Pimephales promelas20.8 g/l96 h StaticInvertebrates: Daphnia magna23,300 mg/l48 hNonylphenol ethoxylate compound N.D.Titanium dioxide N.D.Resorcinol Fish: Pimephales promelas36 - 100 mg/l96 h StaticPimephales promelas100 mg/l96 h flow-throughOncorhynchus mykiss> 100 mg/l96 h flow-throughPimephales promelas53.4 mg/l96 hInvertebrates: Daphnia magna78 mg/l48 hPERSISTENCE AND DEGRADABILITY:Not determined for this product. BIOACCUMULATIVE: Not determined for this product.MOBILITY IN SOIL: Not determined for this product.OTHER ADVERSE EFFECTS: Not determined for this product.13. DISPOSAL CONSIDERATIONSDISPOSAL METHOD: Disposal should be done in accordance with Federal (40CFR Part 261), state and local environmental control regulations. If waste is determined to be hazardous, use licensed hazardous waste transporter and disposal facility.14. TRANSPORT INFORMATIONUS DOT RoadProper Shipping Name: Environmentally hazardous substances, liquid, n.o.s.Hazard Class: 9SECONDARY HAZARD: NoneUN/NA Number: 3082Packing Group: IIIEmergency Response Guide Number: 171For US DOT non-bulk road shipments this material may be classified as NOT REGULATED. For the mostaccurate shipping information, refer to your transportation/compliance department regarding changes inpackage size, mode of shipment or other regulatory descriptors.IATA CargoPROPER SHIPPING NAME: Environmentally hazardous substance, liquid, n.o.s.Hazard Class: 9HAZARD CLASS: NoneUN NUMBER: 3082PACKING GROUP: IIIEMS: 9LIMDGPROPER SHIPPING NAME: Environmentally hazardous substance, liquid, n.o.s.Hazard Class: 9HAZARD CLASS: NoneUN NUMBER: 3082PACKING GROUP: IIIEMS: F-AThe listed transportation classification applies to non-bulk shipments. It does not address regulatory variations due to changes in package size, mode of shipment or other regulatory descriptors. For the most accurate shipping information, refer to your transportation/compliance department.15. REGULATORY INFORMATIONU.S. FEDERAL REGULATIONS: AS FOLLOWS:SARA SECTION 313This product contains the following substances subject to the reporting requirements of Section 313 of Title III of the Superfund Amendment and Reauthorization Act of 1986 and 40 CFR part 372.:Chemical Name CAS Number Weight % Less ThanZinc compound PROPRIETARY10.0%TOXIC SUBSTANCES CONTROL ACT:INVENTORY STATUSThe chemical substances in this product are on the TSCA Section 8 Inventory.EXPORT NOTIFICATIONThis product contains the following chemical substances subject to the reporting requirements of TSCA 12(B) if exported from the United States:None16. OTHER INFORMATIONUnder HazCom 2012 it is optional to continue using the HMIS rating system. It is important to ensure employees have been trained to recognize the different numeric ratings associated with the HazCom 2012 and HMIS schemes.HMIS RATINGS - HEALTH: 2* FLAMMABILITY: 1 PHYSICAL HAZARD: 0* - Indicates a chronic hazard; see Section 2Revision: Section 2, Section 11Effective Date: 08/21/2019DISCLAIMERThe information contained herein is, to the best of our knowledge and belief, accurate. However, since the conditions of handling and use are beyond our control, we make no guarantee of results, and assume no liability for damages incurred by use of this material. It is the responsibility of the user to comply with all applicable federal, state and local laws and regulations.。
CFDA SE (细胞增殖示踪荧光探针) 说明书
CFDA SE (细胞增殖示踪荧光探针) 产品编号产品名称包装C1031 CFDA SE (细胞增殖示踪荧光探针) 5mg产品简介：CFDA SE 的全称为Carboxyfluorescein diacetate, succinimidyl ester ，是一种近年来被广泛应用的细胞增殖检测用荧光探针，也可以用于细胞的荧光示踪。
基于CFDA SE 荧光标记的细胞增殖检测和[3H]-thymidine 掺入、BrdU 标记获得的检测结果完全一致，但同时可以提供更多的细胞增殖信息。
使用CFDA SE 检测可以提供整个细胞群中有多少比例的细胞分裂了1次、2次或更多次数，同时如果和其它荧光探针联用，可以获取不同分裂次数细胞的其它相关信息。
CFDA-SE 的分子式为C 29H 19NO 11，分子量为557.47，CAS number 为150347-59-4。
CFDA SE 可以通透细胞膜，进入细胞后可以被细胞内的酯酶(esterase)催化分解成CFSE ，CFSE 可以偶发性地(spontaneously)并不可逆地和细胞内蛋白的Lysine 残基或其它氨基发生结合反应，并标记这些蛋白。
在加入荧光探针CFDA SE 后大约24小时，即可充分标记细胞。
被CFDA SE 标记的非分裂细胞的荧光非常稳定，稳定标记的时间可达数个月。
CFDA SE 标记细胞的荧光非常均一，比以前使用的其它细胞示踪荧光探针例如PKH26的荧光更加均一，并且分裂后的子代细胞的荧光分配也更均匀。
由于CFDA SE 标记细胞的荧光非常均匀和稳定，每分裂一次子代细胞的荧光会减弱一半，这样通过流式细胞仪检测就可以检测出没有分裂的细胞，分裂一次的细胞(1/2的荧光强度)，分离两次的细胞(1/4的荧光强度)，分裂三次的细胞(1/8的荧光强度)以及类似的其它分裂次数的细胞。
采用CFDA SE 通过流式细胞仪检测获得的检测结果参考右图。
每一个峰代表一种分裂次数的细胞，从右至左的峰通常依次为分裂0次、1次、2次、3次等次数的细胞。
Amtech Tacky 助焊膏系列安全数据表说明书
Inventec Performance Chemicals USA, LLCSAFETY DATA SHEET (SDS)SECTION 1: PRODUCT AND COMPANY IDENTIFICATIONPRODUCT NAME: Amtech Tacky Paste Flux Series: 200, 400, 500, 600, 4000, SynTECH, WSFC-305L and #61 SYNONYMS:Tacky FluxMANUFACTURER: Inventec Performance Chemicals USA, LLCADDRESS:PO Box 989 Deep River, CT 06417 USAPHONE:860-526-8300FAX:860-526-8243EMERGENCY:Infotrac-(800)535-5035REVISION DATE:December 19, 2014REVISION DATE: 3DOCUMENT NAME:SDS-Tacky Flux-008PRODUCT USE:Bonding solder joints in production and repair of circuit boardsSECTION 2: HAZARDS IDENTIFICATIONCHEMICAL NAME:N/ACHEMICAL FAMILY:MixtureCHEMICAL FORMULA:N/AROUTES OF ENTRY: Inhalation, Ingestion, Skin/Eye ContactGHS:Signal Word: WarningHazard statement(s)H302 Harmful if swallowedH317 May cause an allergic skin reactionH320 Causes eye irritationH335 May cause respiratory irritationPrecautionary statement(s)P102 Keep out of reach of childrenP233 Keep container tightly closedP264 Wash hands thoroughly after handlingP270 Do not eat, drink or smoke when using this productP280 Wear protective gloves/protective clothing/eye protection/face protectionP302+P352 IF ON SKIN: Wash with plenty of soap and waterP305+P351 IF IN EYES: Rinse continuously with water for several minutesP404 Store in a closed containerP501 Dispose of contents/containers in accordance with Federal, State/Provincial, and/or local regulations POTENTIAL HEALTH EFFECTS:EYE CONTACT: May cause moderate irritation. Do not allow material to come in contact with eyes.SKIN CONTACT: May cause moderate skin irritation.INHALATION: May cause irritation to the respiratory tract.INGESTION: Harmful if swallowed. May cause irritation to the mouth, throat, and stomach. May cause abdominal discomfort, nausea, vomiting, and/or diarrhea.CHRONIC: Not established.SECTION 2 NOTES:Inventec Performance Chemicals USA, LLC does not recommend, manufacture, market, or endorse any of its products for human consumption.SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTSIngredient CAS Number Exposure LimitsModified Rosins N/A N/APine Oil Derivatives 8000-41-7 N/AProprietary Ingredients N/A N/AMixed Carboxylic Acids N/A N/ASECTION 3 NOTES:Percentages of individual components are not listed as this information is considered a trade secret.SECTION 4: FIRST AID MEASURESEYES: Flush with plenty of water, contact a physician. If contact lenses can be removed easily, flush eyes without contact lenses. SKIN: Wash affected area with plenty of warm, soapy water. If irritation persists, seek medical attention.INGESTION: Call a physician or Poison Control Center immediately. Do not induce vomiting.INHALATION: Remove to fresh air. If not breathing, seek immediate medical attention.SECTION 5: FIRE-FIGHTING MEASURESEXTINGUISHING MEDIA: Dry chemical, foamSPECIAL FIRE FIGHTING PROCEDURES: Do not use water. Use NIOSH-approved self-contained Breathing Apparatusand full protective clothing if involved in a fire.UNUSUAL FIRE AND EXPLOSION HAZARDS:This product does not present any unusual fire and explosion hazards. SECTION 6: ACCIDENTAL RELEASE MEASURESACCIDENTAL RELEASE MEASURES: If material spills or leaks, collect and place into a properly labeled waste container. Remove traces of tacky flux using cloth rags or paper towels moistened with Isopropyl Alcohol. Follow on-site personal protective equipment recommendations.SECTION 6 NOTES:See Sections 2, 4, and 7 for additional information.SECTION 7: HANDLING AND STORAGEHANDLING/STORAGE: Keep containers tightly closed when not in use. Use care to avoid spills. Avoid inhalation of fumes or dust. Avoid contact with eyes, skin, and clothing.OTHER PRECAUTIONS: Empty containers may retain product residues in vapor, liquid, and/or solid form. All labeled hazard precautions should be observed.WORK HYGIENIC PRACTICES: Cosmetics/Food/Drink/Tobacco should not be consumed or used in work areas. Always wash hands after handling material and before applying or using cosmetics/food/drink/tobacco.SECTION 7 NOTES:For industrial use only.SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTIONVENTILATION: Provide sufficient mechanical (general and/or local exhaust) ventilation to maintain exposure below TLVs. RESPIRATORY PROTECTION: Use with adequate ventilation.EYE PROTECTION: Use with appropriate safety glasses.SKIN PROTECTION: Protective gloves and clothing should be worn when handling material. Wash hands thoroughly with soap and water upon leaving the work area.SECTION 9: PHYSICAL AND CHEMICAL PROPERTIESAPPEARANCE: Clear, White, or Yellow to Dark Amber gelODOR: Mild odorODOR THRESHOLD: Not establishedpH as SUPPLIED: N/ASECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)MELTING POINT: Not establishedFREEZING POINT: Not establishedINITIAL BOILING POINT: Not establishedBOILING RANGE: Not establishedFLASH POINT: Not establishedEVAPORATION RATE: Not establishedFLAMMABILITY (solid): Not establishedUPPER/LOWER FLAMMABILITY: Not establishedUPPER/LOWER EXPLOSIVE LIMITS:Not establishedVAPOR PRESSURE (mmHg): N/A (°F/°C)VAPOR DENSITY (AIR = 1): N/A (°F/°C)RELATIVE DENSITY: Not establishedSOLUBILITY IN WATER: PartiallyPARTITION COEFFICIENT (n-octanol/water): Not establishedAUTOIGNITION TEMPERATURE: Not establishedDECOMPOSITION TEMPERATURE: Not establishedVISCOSITY: N/A (°F/°C)SECTION 10: STABILITY AND REACTIVITYSTABILITY: StableCONDITIONS TO AVOID (STABILITY): Freezing temperatures. High temperatures. INCOMPATIBILITY (MATERIAL TO AVOID): Strong oxidizing materialsHAZARDOUS DECOMPOSITION/BY-PRODUCTS: Harmful organic fumes and toxic oxide fumes may form at elevatedtemperatures.POSSIBILITY OF HAZARDOUS REACTIONS: Will not occurSECTION 11: TOXICOLOGICAL INFORMATIONACUTE TOXICITY: Not availableSKIN CORRISION/IRRITATION: Not establishedSERIOUS EYE DAMAGE/IRRITATION: Not availableRESPIRATORY OR SKIN SENSITIZATION: Not establishedGERM CELL MUTAGENICITY: Not availableCARCINOGENICITY: Not availableREPRODUCTIVE TOXICITY: Not availableSTOT-SINGLE EXPOSURE: Not availableSTOT-REPEATED EXPOSURE: Not availableASPIRATION HAZARD: Not availableSECTION 12: ECOLOGICAL INFORMATIONTOXICITY: Product not testedPERSISTENCE AND DEGRADIBILITY: Product not testedBIOACCUMULATIVE POTENTIAL: Product not testedMOBILITY IN SOIL: Product not testedOTHER ADVERSE EFFECTS: Product not testedSECTION 13: DISPOSAL CONSIDERATIONSWASTE DISPOSAL METHOD: Scrap and waste solder should be stored in a dry, sealed container for later disposal. Disposal must be in accordance with Federal, State/Provincial, and Local Regulations.SECTION 14: TRANSPORT INFORMATIONTransport in accordance with applicable regulations and requirements.UN Number: Not availableUN Proper Shipping Name: Not availablePackaging Group:Not applicableEnvironmental Hazards:NoneTRANSPORT HAZARD CLASSES:US DOT Hazardous Material Classification: Tacky Flux is not listed as a DOT hazardous materialWater Transportation: Tacky Flux is not listed as a hazardous materialIATA Hazardous Material Classification: Tacky Flux is not listed as IATA hazardous materialSECTION 15: REGULATORY INFORMATIONAll ingredients used to manufacture this product are listed on the EPA TSCA Inventory.U.S. FEDERAL REGULATIONS: Not regulatedSTATE REGULATIONS: Not regulatedINTERNATIONAL REGULATIONS: Not regulatedSECTION 16: OTHER INFORMATIONHMIS Rating: Health=1 Flammability=1 Physical Hazard=0 Personal Protection=X KEY:N/A: Not applicableGHS: Global Harmonized SystemOSHA: Occupational Safety and Health AdministrationACGIH: American Conference of Governmental Industrial HygienistsNTP: National Toxicology ProgramIARC: International Agency for Research on CancerCAS: Chemical Abstract ServiceNIOSH: National Institute for Occupational Safety & HealthSTOT: Specific target organ toxicityTLV: Threshold limit valueUS DOT: United States Department of TransportationDOT: Department of TransportationIATA: International Air Transport AssociationEPA:Environmental Protection AgencyTSCA:Toxic Substance Control ActHMIS:Hazardous Material Identification SystemPREPARATION INFORMATION:This update supersedes all previously released documents.PREPARED BY: Wendy W. GesickAPPROVED BY: Leigh W. GesickDISCLAIMER:The information contained herein is based on data considered to be accurate but does not purport to be all-inclusive and shall be used only as a guide. No warranty is expressed or implied regarding the accuracy of this data and Inventec Performance Chemicals USA, LLC shall not be held liable for any damage resulting from any handling or contact with the above product. Liability is expressly disclaimed for loss or injury arising out of use of this information or the use of any materials designated. This material is not for resale, unauthorized distribution, or personal use.。
JNJ-39758979-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Mar.-13-2018Print Date:Mar.-13-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :JNJ-39758979Catalog No. :HY-101189CAS No. :1046447-90-81.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:C11H19N5Molecular Weight:221.30CAS No. :1046447-90-84. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature: 4°C, protect from lightMSDStheunstable Shipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
Product Name:
KPT-330CAS No.:
1393477-72-9Cat. No.:
HY-17536
Product Data Sheet
MWt:
443.31Formula:
C17H11F6N7O Purity :>98%
Solubility:
DMSO mg/mL (<1 mM); Water
Mechanisms:
Biological Activity:
KPT-330,analog of KPT-185,is an orally bioavailable selective CRM1inhibitor.
Pathways:Cell Cycle/DNA Damage; Target:CRM1mg/mL (<1 mM)
KPT 330, analog of KPT 185, is an orally bioavailable selective CRM1 inhibitor.
IC50 value:
Target: CRM1in vitro: As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL cells and elicits rapid apoptotic response. KPT-330 also reduces cell growth in MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3, and DND-41 cell lines, with IC50 values of 34-203 nM [1]. in vivo: KPT-330 dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–
11) in vivo, with little toxicity to normal haematopoietic cells [1]. In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330References:
[1]. Etchin J, et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia Br J Haematol 2013Apr;161(1):117-27directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and
NFATc1, with minimal impact on osteoblasts and BMSCs [2]....
leukaemia. Br J Haematol. 2013 Apr;161(1):11727.[2]. Tai YT, et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia. 2014
Jan;28(1):155-65.Caution: Not fully tested. For research purposes only
Medchemexpress LLC
18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A
E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。