RG108_DataSheet_MedChemExpress
209种多氯联苯单体编号及中英文对照与CAS号
209种多氯联苯单体PCB序号中文名称CAS 英文名称PCB-001 2-氯联苯2051-60-7 2-Chlorobiphenyl PCB-002 3-氯联苯2051-61-8 3-Chlorobiphenyl PCB-003 4-氯联苯2051-62-9 4-Chlorobiphenyl PCB-004 2,2'-二氯联苯13029-08-8 2,2'-Dichlorobiphenyl PCB-005 2,3-二氯联苯16605-91-7 2,3-Dichlorobiphenyl PCB-006 2,3'-二氯联苯25569-80-6 2,3'-Dichlorobiphenyl PCB-007 2,4-二氯联苯33284-50-3 2,4-Dichlorobiphenyl PCB-008 2,4'-二氯联苯34883-43-7 2,4'-Dichlorobiphenyl PCB-009 2,5-二氯联苯34883-39-1 2,5-Dichlorobiphenyl PCB-010 2,6-二氯联苯33146-45-1 2,6-Dichlorobiphenyl PCB-011 3,3'-二氯联苯2050-67-1 3,3'-Dichlorobiphenyl PCB-012 3,4-二氯联苯2974-92-7 3,4-Dichlorobiphenyl PCB-013 3,4'-二氯联苯2974-90-5 3,4'-Dichlorobiphenyl PCB-014 3,5-二氯联苯34883-41-5 3,5-Dichlorobiphenyl PCB-015 4,4'-二氯联苯2050-68-2 4,4'-Dichlorobiphenyl PCB-016 2,2',3-三氯联苯38444-78-9 2,2',3-Trichlorobiphenyl PCB-017 2,2',4-三氯联苯37680-66-3 2,2',4-Trichlorobiphenyl PCB-018 2,2',5-三氯联苯37680-65-2 2,2',5-Trichlorobiphenyl PCB-019 2,2',6-三氯联苯38444-73-4 2,2',6-Trichlorobiphenyl PCB-020 2,3,3'-三氯联苯38444-84-7 2,3,3'-Trichlorobiphenyl PCB-021 2,3,4-三氯联苯55702-46-0 2,3,4-Trichlorobiphenyl PCB-022 2,3,4'-三氯联苯38444-85-8 2,3,4'-Trichlorobiphenyl PCB-023 2,3,5-三氯联苯55720-44-0 2,3,5-Trichlorobiphenyl PCB-024 2,3,6-三氯联苯55702-45-9 2,3,6-Trichlorobiphenyl PCB-025 2,3',4-三氯联苯55712-37-3 2,3',4-Trichlorobiphenyl PCB-026 2,3',5-三氯联苯38444-81-4 2,3',5-Trichlorobiphenyl PCB-027 2,3',6-三氯联苯38444-76-7 2,3',6-Trichlorobiphenyl PCB-028 2,4,4'-三氯联苯7012-37-5 2,4,4'-Trichlorobiphenyl PCB-029 2,4,5-三氯联苯15862-07-4 2,4,5-Trichlorobiphenyl PCB-030 2,4,6-三氯联苯35693-92-6 2,4,6-Trichlorobiphenyl PCB-031 2,4',5-三氯联苯16606-02-3 2,4',5-Trichlorobiphenyl PCB-032 2,4',6-三氯联苯38444-77-4 2,4',6-Trichlorobiphenyl PCB-033 2',3,4-三氯联苯38444-86-9 2',3,4-Trichlorobiphenyl PCB-034 2',3,5-三氯联苯37680-68-5 2',3,5-Trichlorobiphenyl PCB-035 3,3',4-三氯联苯37680-69-6 3,3',4-Trichlorobiphenyl PCB-036 3,3',5-三氯联苯38444-87-0 3,3',5-Trichlorobiphenyl PCB-037 3,4,4'-三氯联苯38444-90-5 3,4,4'-Trichlorobiphenyl PCB-038 3,4,5-三氯联苯53555-66-1 3,4,5-Trichlorobiphenyl PCB-039 3,4',5-三氯联苯38444-88-1 3,4',5-Trichlorobiphenyl PCB-040 2,2',3,3'-四氯联苯38444-93-8 2,2',3,3'-Tetrachlorobiphenyl PCB-041 2,2',3,4-四氯联苯52663-59-9 2,2',3,4-Tetrachlorobiphenyl PCB-042 2,2',3,4'-四氯联苯36559-22-5 2,2',3,4'-Tetrachlorobiphenyl PCB-043 2,2',3,5-四氯联苯70362-46-8 2,2',3,5-Tetrachlorobiphenyl PCB-044 2,2',3,5'-四氯联苯41464-39-5 2,2',3,5'-Tetrachlorobiphenyl PCB-045 2,2',3,6-四氯联苯70362-45-7 2,2',3,6-Tetrachlorobiphenyl PCB-046 2,2',3,6'-四氯联苯41464-47-5 2,2',3,6'-TetrachlorobiphenylPCB-050 2,2',4,6-四氯联苯62796-65-0 2,2',4,6-Tetrachlorobiphenyl PCB-051 2,2',4,6'-四氯联苯68194-04-7 2,2',4,6'-Tetrachlorobiphenyl PCB-052 2,2',5,5'-四氯联苯35693-99-3 2,2',5,5'-Tetrachlorobiphenyl PCB-053 2,2',5,6'-四氯联苯41464-41-9 2,2',5,6'-Tetrachlorobiphenyl PCB-054 2,2',6,6'-四氯联苯15968-05-5 2,2',6,6'-Tetrachlorobiphenyl PCB-055 2,3,3',4-四氯联苯74338-24-2 2,3,3',4-Tetrachlorobiphenyl PCB-056 2,3,3',4'-四氯联苯41464-43-1 2,3,3',4'-Tetrachlorobiphenyl PCB-057 2,3,3',5-四氯联苯70424-67-8 2,3,3',5-Tetrachlorobiphenyl PCB-058 2,3,3',5'-四氯联苯41464-49-7 2,3,3',5'-Tetrachlorobiphenyl PCB-059 2,3,3',6-四氯联苯74472-33-6 2,3,3',6-Tetrachlorobiphenyl PCB-060 2,3,4,4'-四氯联苯33025-41-1 2,3,4,4'-Tetrachlorobiphenyl PCB-061 2,3,4,5-四氯联苯33284-53-6 2,3,4,5-Tetrachlorobiphenyl PCB-062 2,3,4,6-四氯联苯54230-22-7 2,3,4,6-Tetrachlorobiphenyl PCB-063 2,3,4',5-四氯联苯74472-34-7 2,3,4',5-Tetrachlorobiphenyl PCB-064 2,3,4',6-四氯联苯52663-58-8 2,3,4',6-Tetrachlorobiphenyl PCB-065 2,3,5,6-四氯联苯33284-54-7 2,3,5,6-Tetrachlorobiphenyl PCB-066 2,3',4,4'-四氯联苯32598-10-0 2,3',4,4'-Tetrachlorobiphenyl PCB-067 2,3',4,5-四氯联苯73557-53-8 2,3',4,5-Tetrachlorobiphenyl PCB-068 2,3',4,5'-四氯联苯73575-52-7 2,3',4,5'-Tetrachlorobiphenyl PCB-069 2,3',4,6-四氯联苯60233-24-1 2,3',4,6-Tetrachlorobiphenyl PCB-070 2,3',4',5-四氯联苯32598-11-1 2,3',4',5-Tetrachlorobiphenyl PCB-071 2,3',4',6-四氯联苯41464-46-4 2,3',4',6-Tetrachlorobiphenyl PCB-072 2,3',5,5'-四氯联苯41464-42-0 2,3',5,5'-Tetrachlorobiphenyl PCB-073 2,3',5',6-四氯联苯74338-23-1 2,3',5',6-Tetrachlorobiphenyl PCB-074 2,4,4',5-四氯联苯32690-93-0 2,4,4',5-Tetrachlorobiphenyl PCB-075 2,4,4',6-四氯联苯32598-12-2 2,4,4',6-Tetrachlorobiphenyl PCB-076 2',3,4,5-四氯联苯70362-48-0 2',3,4,5-Tetrachlorobiphenyl PCB-077 3,3',4,4'-四氯联苯32598-13-3 3,3',4,4'-Tetrachlorobiphenyl PCB-078 3,3',4,5-四氯联苯70362-49-1 3,3',4,5-Tetrachlorobiphenyl PCB-079 3,3',4,5'-四氯联苯41464-48-6 3,3',4,5'-Tetrachlorobiphenyl PCB-080 3,3',5,5'-四氯联苯33284-52-5 3,3',5,5'-Tetrachlorobiphenyl PCB-081 3,4,4',5-四氯联苯70362-50-4 3,4,4',5-Tetrachlorobiphenyl PCB-082 2,2',3,3',4-五氯联苯52663-62-4 2,2',3,3',4-Pentachlorobiphenyl PCB-083 2,2',3,3',5-五氯联苯60145-20-2 2,2',3,3',5-Pentachlorobiphenyl PCB-084 2,2',3,3',6-五氯联苯52663-60-2 2,2',3,3',6-Pentachlorobiphenyl PCB-085 2,2',3,4,4'-五氯联苯65510-45-4 2,2',3,4,4'-Pentachlorobiphenyl PCB-086 2,2',3,4,5-五氯联苯55312-69-1 2,2',3,4,5-Pentachlorobiphenyl PCB-087 2,2',3,4,5'-五氯联苯38380-02-8 2,2',3,4,5'-Pentachlorobiphenyl PCB-088 2,2',3,4,6-五氯联苯55215-17-3 2,2',3,4,6-Pentachlorobiphenyl PCB-089 2,2',3,4,6'-五氯联苯73575-57-2 2,2',3,4,6'-Pentachlorobiphenyl PCB-090 2,2',3,4',5-五氯联苯68194-07-0 2,2',3,4',5-Pentachlorobiphenyl PCB-091 2,2',3,4',6-五氯联苯68194-05-8 2,2',3,4',6-Pentachlorobiphenyl PCB-092 2,2',3,5,5'-五氯联苯52663-61-3 2,2',3,5,5'-Pentachlorobiphenyl PCB-093 2,2',3,5,6-五氯联苯73575-56-1 2,2',3,5,6-Pentachlorobiphenyl PCB-094 2,2',3,5,6'-五氯联苯73575-55-0 2,2',3,5,6'-Pentachlorobiphenyl PCB-095 2,2',3,5',6-五氯联苯38379-99-6 2,2',3,5',6-PentachlorobiphenylPCB-099 2,2',4,4',5-五氯联苯38380-01-7 2,2',4,4',5-Pentachlorobiphenyl PCB-100 2,2',4,4',6-五氯联苯39485-83-1 2,2',4,4',6-Pentachlorobiphenyl PCB-101 2,2',4,5,5'-五氯联苯37680-73-2 2,2',4,5,5'-Pentachlorobiphenyl PCB-102 2,2',4,5,6'-五氯联苯68194-06-9 2,2',4,5,6'-Pentachlorobiphenyl PCB-103 2,2',4,5',6-五氯联苯60145-21-3 2,2',4,5',6-Pentachlorobiphenyl PCB-104 2,2',4,6,6'-五氯联苯56558-16-8 2,2',4,6,6'-Pentachlorobiphenyl PCB-105 2,3,3',4,4'-五氯联苯32598-14-4 2,3,3',4,4'-Pentachlorobiphenyl PCB-106 2,3,3',4,5-五氯联苯70424-69-0 2,3,3',4,5-Pentachlorobiphenyl PCB-107 2,3,3',4',5-五氯联苯70424-68-9 2,3,3',4',5-Pentachlorobiphenyl PCB-108 2,3,3',4,5'-五氯联苯70362-41-3 2,3,3',4,5'-Pentachlorobiphenyl PCB-109 2,3,3',4,6-五氯联苯74472-35-8 2,3,3',4,6-Pentachlorobiphenyl PCB-110 2,3,3',4',6-五氯联苯38380-03-9 2,3,3',4',6-Pentachlorobiphenyl PCB-111 2,3,3',5,5'-五氯联苯39635-32-0 2,3,3',5,5'-Pentachlorobiphenyl PCB-112 2,3,3',5,6-五氯联苯74472-36-9 2,3,3',5,6-Pentachlorobiphenyl PCB-113 2,3,3',5',6-五氯联苯68194-10-5 2,3,3',5',6-Pentachlorobiphenyl PCB-114 2,3,4,4',5-五氯联苯74472-37-0 2,3,4,4',5-Pentachlorobiphenyl PCB-115 2,3,4,4',6-五氯联苯74472-38-1 2,3,4,4',6-Pentachlorobiphenyl PCB-116 2,3,4,5,6-五氯联苯18259-05-7 2,3,4,5,6-Pentachlorobiphenyl PCB-117 2,3,4',5,6-五氯联苯68194-11-6 2,3,4',5,6-Pentachlorobiphenyl PCB-118 2,3',4,4',5-五氯联苯31508-00-6 2,3',4,4',5-Pentachlorobiphenyl PCB-119 2,3',4,4',6-五氯联苯56558-17-9 2,3',4,4',6-Pentachlorobiphenyl PCB-120 2,3',4,5,5'-五氯联苯68194-12-7 2,3',4,5,5'-Pentachlorobiphenyl PCB-121 2,3',4,5',6-五氯联苯56558-18-0 2,3',4,5',6-Pentachlorobiphenyl PCB-122 2',3,3',4,5-五氯联苯76842-07-4 2',3,3',4,5-Pentachlorobiphenyl PCB-123 2',3,4,4',5-五氯联苯65510-44-3 2',3,4,4',5-Pentachlorobiphenyl PCB-124 2',3,4,5,5'-五氯联苯70424-70-3 2',3,4,5,5'-Pentachlorobiphenyl PCB-125 2',3,4,5,6'-五氯联苯74472-39-2 2',3,4,5,6'-Pentachlorobiphenyl PCB-126 3,3',4,4',5-五氯联苯57465-28-8 3,3',4,4',5-Pentachlorobiphenyl PCB-127 3,3',4,5,5'-五氯联苯39635-33-1 3,3',4,5,5'-Pentachlorobiphenyl PCB-128 2,2',3,3',4,4'-六氯联苯38380-07-3 2,2',3,3',4,4'-Hexachlorobiphenyl PCB-129 2,2',3,3',4,5-六氯联苯55215-18-4 2,2',3,3',4,5-Hexachlorobiphenyl PCB-130 2,2',3,3',4,5'-六氯联苯52663-66-8 2,2',3,3',4,5'-Hexachlorobiphenyl PCB-131 2,2',3,3',4,6-六氯联苯61798-70-7 2,2',3,3',4,6-Hexachlorobiphenyl PCB-132 2,2',3,3',4,6'-六氯联苯38380-05-1 2,2',3,3',4,6'-Hexachlorobiphenyl PCB-133 2,2',3,3',5,5'-六氯联苯35694-04-3 2,2',3,3',5,5'-Hexachlorobiphenyl PCB-134 2,2',3,3',5,6-六氯联苯52704-70-8 2,2',3,3',5,6-Hexachlorobiphenyl PCB-135 2,2',3,3',5,6'-六氯联苯52744-13-5 2,2',3,3',5,6'-Hexachlorobiphenyl PCB-136 2,2',3,3',6,6'-六氯联苯38411-22-2 2,2',3,3',6,6'-Hexachlorobiphenyl PCB-137 2,2',3,4,4',5-六氯联苯35694-06-5 2,2',3,4,4',5-Hexachlorobiphenyl PCB-138 2,2',3,4,4',5'-六氯联苯35065-28-2 2,2',3,4,4',5'-Hexachlorobiphenyl PCB-139 2,2',3,4,4',6-六氯联苯56030-56-9 2,2',3,4,4',6-Hexachlorobiphenyl PCB-140 2,2',3,4,4',6'-六氯联苯59291-64-4 2,2',3,4,4',6'-Hexachlorobiphenyl PCB-141 2,2',3,4,5,5'-六氯联苯52712-04-6 2,2',3,4,5,5'-Hexachlorobiphenyl PCB-142 2,2',3,4,5,6-六氯联苯41411-61-4 2,2',3,4,5,6-Hexachlorobiphenyl PCB-143 2,2',3,4,5,6'-六氯联苯68194-15-0 2,2',3,4,5,6'-Hexachlorobiphenyl PCB-144 2,2',3,4,5',6-六氯联苯68194-14-9 2,2',3,4,5',6-HexachlorobiphenylPCB-148 2,2',3,4',5,6'-六氯联苯74472-41-6 2,2',3,4',5,6'-Hexachlorobiphenyl PCB-149 2,2',3,4',5',6-六氯联苯38380-04-0 2,2',3,4',5',6-Hexachlorobiphenyl PCB-150 2,2',3,4',6,6'-六氯联苯68194-08-1 2,2',3,4',6,6'-Hexachlorobiphenyl PCB-151 2,2',3,5,5',6-六氯联苯52663-63-5 2,2',3,5,5',6-Hexachlorobiphenyl PCB-152 2,2',3,5,6,6'-六氯联苯68194-09-2 2,2',3,5,6,6'-Hexachlorobiphenyl PCB-153 2,2',4,4',5,5'-六氯联苯35065-27-1 2,2',4,4',5,5'-Hexachlorobiphenyl PCB-154 2,2',4,4',5,6'-六氯联苯60145-22-4 2,2',4,4',5,6'-Hexachlorobiphenyl PCB-155 2,2',4,4',6,6'-六氯联苯33979-03-2 2,2',4,4',6,6'-Hexachlorobiphenyl PCB-156 2,3,3',4,4',5-六氯联苯38380-08-4 2,3,3',4,4',5-Hexachlorobiphenyl PCB-157 2,3,3',4,4',5'-六氯联苯69782-90-7 2,3,3',4,4',5'-Hexachlorobiphenyl PCB-158 2,3,3',4,4',6-六氯联苯74472-42-7 2,3,3',4,4',6-Hexachlorobiphenyl PCB-159 2,3,3',4,5,5'-六氯联苯39635-35-3 2,3,3',4,5,5'-Hexachlorobiphenyl PCB-160 2,3,3',4,5,6-六氯联苯41411-62-5 2,3,3',4,5,6-Hexachlorobiphenyl PCB-161 2,3,3',4,5',6-六氯联苯74474-43-8 2,3,3',4,5',6-Hexachlorobiphenyl PCB-162 2,3,3',4',5,5'-六氯联苯39635-34-2 2,3,3',4',5,5'-Hexachlorobiphenyl PCB-163 2,3,3',4',5,6-六氯联苯74472-44-9 2,3,3',4',5,6-Hexachlorobiphenyl PCB-164 2,3,3',4',5',6-六氯联苯74472-45-0 2,3,3',4',5',6-Hexachlorobiphenyl PCB-165 2,3,3',5,5',6-六氯联苯74472-46-1 2,3,3',5,5',6-Hexachlorobiphenyl PCB-166 2,3,4,4',5,6-六氯联苯41411-63-6 2,3,4,4',5,6-Hexachlorobiphenyl PCB-167 2,3',4,4',5,5'-六氯联苯52663-72-6 2,3',4,4',5,5'-Hexachlorobiphenyl PCB-168 2,3',4,4',5',6-六氯联苯59291-65-5 2,3',4,4',5',6-Hexachlorobiphenyl PCB-169 3,3',4,4',5,5'-六氯联苯32774-16-6 3,3',4,4',5,5'-Hexachlorobiphenyl PCB-170 2,2',3,3',4,4',5-七氯联苯35065-30-6 2,2',3,3',4,4',5-Heptachlorobiphenyl PCB-171 2,2',3,3',4,4',6-七氯联苯52663-71-5 2,2',3,3',4,4',6-Heptachlorobiphenyl PCB-172 2,2',3,3',4,5,5'-七氯联苯52663-74-8 2,2',3,3',4,5,5'-Heptachlorobiphenyl PCB-173 2,2',3,3',4,5,6-七氯联苯68194-16-1 2,2',3,3',4,5,6-Heptachlorobiphenyl PCB-174 2,2',3,3',4,5,6'-七氯联苯38411-25-5 2,2',3,3',4,5,6'-Heptachlorobiphenyl PCB-175 2,2',3,3',4,5',6-七氯联苯40186-70-7 2,2',3,3',4,5',6-Heptachlorobiphenyl PCB-176 2,2',3,3',4,6,6'-七氯联苯52663-65-7 2,2',3,3',4,6,6'-Heptachlorobiphenyl PCB-177 2,2',3,3',4',5,6-七氯联苯52663-70-4 2,2',3,3',4',5,6-Heptachlorobiphenyl PCB-178 2,2',3,3',5,5',6-七氯联苯52663-67-9 2,2',3,3',5,5',6-Heptachlorobiphenyl PCB-179 2,2',3,3',5,6,6'-七氯联苯52663-64-6 2,2',3,3',5,6,6'-Heptachlorobiphenyl PCB-180 2,2',3,4,4',5,5'-七氯联苯35065-29-3 2,2',3,4,4',5,5'-Heptachlorobiphenyl PCB-181 2,2',3,4,4',5,6-七氯联苯74472-47-2 2,2',3,4,4',5,6-Heptachlorobiphenyl PCB-182 2,2',3,4,4',5,6'-七氯联苯60145-23-5 2,2',3,4,4',5,6'-Heptachlorobiphenyl PCB-183 2,2',3,4,4',5',6-七氯联苯52663-69-1 2,2',3,4,4',5',6-Heptachlorobiphenyl PCB-184 2,2',3,4,4',6,6'-七氯联苯74472-48-3 2,2',3,4,4',6,6'-Heptachlorobiphenyl PCB-185 2,2',3,4,5,5',6-七氯联苯52712-05-7 2,2',3,4,5,5',6-Heptachlorobiphenyl PCB-186 2,2',3,4,5,6,6'-七氯联苯74472-49-4 2,2',3,4,5,6,6'-Heptachlorobiphenyl PCB-187 2,2',3,4',5,5',6-七氯联苯52663-68-0 2,2',3,4',5,5',6-Heptachlorobiphenyl PCB-188 2,2',3,4',5,6,6'-七氯联苯74487-85-7 2,2',3,4',5,6,6'-Heptachlorobiphenyl PCB-189 2,3,3',4,4',5,5'-七氯联苯39635-31-9 2,3,3',4,4',5,5'-Heptachlorobiphenyl PCB-190 2,3,3',4,4',5,6-七氯联苯41411-64-7 2,3,3',4,4',5,6-Heptachlorobiphenyl PCB-191 2,3,3',4,4',5',6-七氯联苯74472-50-7 2,3,3',4,4',5',6-Heptachlorobiphenyl PCB-192 2,3,3',4,5,5',6-七氯联苯74472-51-8 2,3,3',4,5,5',6-Heptachlorobiphenyl PCB-193 2,3,3',4',5,5',6-七氯联苯69782-91-8 2,3,3',4',5,5',6-HeptachlorobiphenylPCB-197 2,2',3,3',4,4',6,6'-八氯联苯33091-17-7 2,2',3,3',4,4',6,6'-Octachlorobiphenyl PCB-198 2,2',3,3',4,5,5',6-八氯联苯68194-17-2 2,2',3,3',4,5,5',6-Octachlorobiphenyl PCB-200 2,2',3,3',4,5,6,6'-八氯联苯52663-73-7 2,2',3,3',4,5,6,6'-Octachlorobiphenyl PCB-201 2,2',3,3',4,5',6,6'-八氯联苯40186-71-8 2,2',3,3',4,5',6,6'-Octachlorobiphenyl PCB-199 2,2',3,3',4,5,5',6'-八氯联苯52663-75-9 2,2',3,3',4,5,5',6'-Octachlorobiphenyl PCB-202 2,2',3,3',5,5',6,6'-八氯联苯2136-99-4 2,2',3,3',5,5',6,6'-Octachlorobiphenyl PCB-203 2,2',3,4,4',5,5',6-八氯联苯52663-76-0 2,2',3,4,4',5,5',6-Octachlorobiphenyl PCB-204 2,2',3,4,4',5,6,6'-八氯联苯74472-52-9 2,2',3,4,4',5,6,6'-Octachlorobiphenyl PCB-205 2,3,3',4,4',5,5',6-八氯联苯74472-53-0 2,3,3',4,4',5,5',6-Octachlorobiphenyl PCB-206 2,2',3,3',4,4',5,5',6-九氯联苯40186-72-9 2,2',3,3',4,4',5,5',6-Nonachlorobiphenyl PCB-207 2,2',3,3',4,4',5,6,6'-九氯联苯52663-79-3 2,2',3,3',4,4',5,6,6'-Nonachlorobiphenyl PCB-208 2,2',3,3',4,5,5',6,6'-九氯联苯52663-77-1 2,2',3,3',4,5,5',6,6'-Nonachlorobiphenyl PCB-209 十氯联苯2051-24-3 2,2',3,3',4,4',5,5',6,6'-Decachlorobiphenyl。
HSF1A_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:HSF1A is a cell–permeable activator of heat shock transcription factor 1 (HSF1).IC50 & Target: HSF1[1]In Vitro: HSF1A protects cells from stress–induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis. Genetic inactivation or depletion of the TRiC complex results in human HSF1 activation and HSF1A inhibits the direct interaction between purified TRiC and HSF1 in vitro. Moreover, fluorescence anisotropy experiments using FITC coupled to HSF1A demonstrates that HSF1A–FITC binds to a purified Tcp1 subunit of TRiC with an affinity of approximately 600 nM. This is validated qualitatively via titration of purified Tcp1 into binding reactions containing 500 nM Biotin or HSF1A–Biotin [1]. Quantification bycounting the number of cell containing aggregates as a function of the total number of cells reveals that at HSF1A concentrations as low as 2 μM, a reduced number of aggregate–containing cells are observed. The fraction of cells containing aggregates continued to decrease in a dose–dependent manner such that pretreatment with 12 μM HSF1A resulta in ~20% of the cells exhibiting aggregates visible by fluorescence microscopy [2].In Vivo: HSF1A enhances HSF1 activity, stabilizes HSF1 expression and minimizes Doxorubicin (DOX)–induced cardiac damage. WKY rats are challenged with DOX (accumulated dose: 30 mg/kgw), and DOX combined with HSF1A (100 mg/kgw/day). Supplementation with HSF1A significantly elevates cardiac functions back to the levels of the control group. HSF1A has been shown to stimulate human HSF1 nuclear translocation, elevate protein chaperone expression and ameliorate protein misfolding and cell death in aneurodegenerative disease model. The echocardiographic results show that HSF1A also alleviates DOX–induced failures in cardiac function [3].PROTOCOL (Extracted from published papers and Only for reference)Kinase Assay:[1]Protein extracts are generated from mammalian, yeast and E. coli cultures using biotin–binding buffer (20 mM HEPES,5 mM MgCl 2, 1 mM EDTA, 100 mM KCl, 0.03% NP–40) supplemented with 1% Trition–X100 and protease inhibitors. Approximately 0.5mg of protein extract is incubated with 100 μM HSF1A–Biotin for 4 h at 4°C and HSF1A–Biotin associated proteins captured by with NeutrAvidin Agarose Resin. After washing in biotin binding buffer proteins are eluted using 50 μL biotin elution buffer (100 mM Tris,150 mM NaCl, 0.1 mM EDTA, 2 mM D–biotin), resolved on a 4–20% SDS–PAGE, and immunoblotted. For purified TRiC and Hsp70analyses, 5 nM protein is incubated in biotin–binding buffer+0.5% Triton X–100 with 100 μM biotin or 100 μM HSF1A–Biotin for 4 h at 4°C and captured with NeutrAvidin Resin. For NiNTA purified yeast Tcp1, different concentrations of Tcp1 0.5 μM, 1 mM, 2 mM, 3 mM and 4 mM in 25 mM Hepes pH 7.5, 150 mM NaCl are incubated with 0.5 μM Biotin or HSF1A–Biotin for 4 h at 4°C and captured with NeutrAvidin Resin [1].Cell Assay:[2]PC12 cells seeded into a 96–well plate (5×104 cells/well) are treated with increasing concentrations of HSF1A (2, 4, 8 andProduct Name:HSF1A Cat. No.:HY-103000CAS No.:1196723-93-9Molecular Formula:C21H19N3O2S2Molecular Weight:409.52Target:HSP Pathway:Cell Cycle/DNA Damage; Metabolic Enzyme/Protease Solubility:DMSO: ≥ 150 mg/mL12 μM) for 15 h, at which time httQ74–GFP expression is stimulated by incubation in the presence of 1 μg/mL Doxycycline for 5 d. Cell viability is assessed via the XTT viability assay[2].Animal Administration:[3]Rat[3]Ten–week–old Wistar Kyoto rats (WKY) are used. The rats are housed at a constant temperature (22°C) on a 12–h light/dark cycle with food and tap water. The animals are arranged into three groups: WKY rats (the control group), DOX rats and DOX rats treated with HSF1A. Each group contain five animals. The DOX group is injected with DOX (5 mg/kg) for 6 consecutive weeks intraperitoneal injection to achieve a cumulative dose of 30 mg/kg, which has been well documented to achieve cardiotoxicity. The small molecular HSF1 activator HSF1A (100 mg/kg/day) is injected intraperitoneally.References:[1]. Neef DW, et al. A direct regulatory interaction between chaperonin TRiC and stress–responsive transcription factor HSF1. Cell Rep. 2014 Nov 6;9(3):955–66.[2]. Neef DW, et al. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol. 2010 Jan 19;8(1):e1000291.[3]. Huang CY, et al. Doxorubicin attenuates CHIP–guarded HSF1 nuclear translocation and protein stability to trigger IGF–IIR–dependent cardiomyocyte death. Cell Death Dis. 2016 Nov 3;7(11):e2455.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
CIL56-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Jan.-07-2019Print Date:Jan.-07-20191. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :CIL56Catalog No. :HY-112063CAS No. :300802-28-21.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4), H302Acute aquatic toxicity (Category 1), H400Chronic aquatic toxicity (Category 1), H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word No data availableHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effectsPrecautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor ⁄ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents ⁄ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:C23H27N3O5S2Molecular Weight:489.61CAS No. :300802-28-24. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077 Class: 9 Packing group: III EMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutantIATAUN number: 3077 Class: 9 Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis)reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:Acute Health Hazard16. OTHER INFORMATIONCopyright 2019 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Gelucire-14-44-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Nov.-23-2018Print Date:Nov.-23-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Gelucire 14/44Catalog No. :HY-Y1892CAS No. :121548-04-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:N/AMolecular Weight:N/ACAS No. :121548-04-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Pure form-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Oil)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
RG108_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :RG108Catalog No. :HY-13642CAS No. :48208-26-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:N⁻Phthalyl⁻L⁻tryptophan; RG 108; RG⁻108Formula:C19H14N2O4Molecular Weight:334.33CAS No. :48208-26-04. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance Light yellow to green yellow (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
RG108_48208-26-0_DataSheet_MedChemExpress
Product Name: CAS No.: Cat. No.: MWt: Formula: Purity :
RG108 48208-26-0 HY-13642 334.33 C19H14N2O4 >98%
Solubility:
DMSO 100 mM Ethanol 100 mM
Mechanisms: Pathways:Cell Cycle/DNA Damage; Target:DNMT g y Biological Activity: RG108 is a non-nucleoside DNA methyltransferase (DNMT) inhibitor. RG108 reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture. RG108 enhances the efficiency of induced pluripotent stem cell (iPS) genera Jurate Savickiene, Grazina Treigyte, Arune Jazdauskaite, et al. DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and Ecadherin re-expression by chromatin remodeling. Cell Biology International. 2012, 36(11): 10671078. [2]. Savickiene J, Treigyte G, Borutinskaite VV, et al. Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells. Cell Mol Biol Lett. 2012;17(4):501-25. [3]. Stresemann C, Brueckner B, Musch T, et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 2006 Mar 1;66(5):2794-800. [4]. Esther Schirrmacher, Carmen Beck, Bodo Brueckner, et al. Synthesis and in Vitro Evaluation of Biotinylated RG108:?A High Affinity Compound for S...
TIS108独脚金内酯内源合成抑制剂
TIS108/独脚金内酯内源合成抑制剂TIS108/独脚金内酯内源合成抑制剂英文名:TIS108北京华越洋5123-5mg 5mg 瓶科研试剂，植物试剂北京华越洋 5123-25mg 25mg 瓶科研试剂，植物试剂北京华越洋5123-100mg 100mg 瓶科研试剂，植物试剂TIS108/独脚金内酯内源合成抑制剂,Tis108溶于丙酮。
可以抑制植物体内的独脚金内酯合成，一般用作对照试验。
TIS108/独脚金内酯内源合成抑制剂CAS:1315459-30-3分子量:335.40;分子式:C20H21N3O2;纯度:＞98%TIS108/独脚金内酯内源合成抑制剂,储存条件:-20℃干燥避光保存TIS108 is a triazole-type strigolactone (SL)-biosynthesis inhibitor that reduces the level of 2'-epi-5-deoxystrigol (epi-5DS) in rice. Here we report the effects of TIS108 on Arabidopsis. Treatment of TIS108 increased the number of branches and repressed root hair elongation as was observed in SL-deficient mutants, and co-application of GR24, a synthetic SL analog, recovered the TIS108-induced phenotype to that of wild-type. In addition, MAX3 and MAX4 genes in the SL-biosynthesis pathway were upregulated in TIS108-treated Arabidopsis, probably due to feedback regulation caused by SL deficiency. These results indicate that TIS108 is an effective tool for regulating SL production in Arabidopsis.TIS108/独脚金内酯内源合成抑制剂,此产品为strigolactone（独脚金内酯）的合成抑制剂，对于植物内源独脚金内酯的合成具有一定的抑制作用。
酸酚消毒剂标签中文翻译
再订购编号：6841-08 净容量：3.78升（1加仑）本产品无菌，除非包装被破坏。
当用软水或硬水（每1Kg水中含400mg CaCO3）稀释后，即便在有机质（5%血清）存在的条件下，本产品可以作为有效的：杀细菌剂·杀真菌剂·杀病毒剂·杀结核杆菌剂·除臭剂·清洁剂·消毒剂有效成分：邻苯基苯酚………………………………………..7.7%对叔戊基苯酚……………………………………..7.6%惰性成分……………………………………….. 84.7%总计………………………………………..……100.0%EPA注册编号：1043-91 EPA批准号：1043-MO-002211-KS-001危险请阅读侧边表格中补充的警示说明。
仅供工业和社会公共机构使用。
STERIS公司美国密苏里州，邮编63133，圣路易斯市，Page大街7501号。
800-548-4873本产品是一种无菌、多用途的人工非碱性苯酚类杀菌清洁剂，是特别开发的一个在硬水和血清中均能发挥良好消毒作用的浓缩系统，使用于无菌室和无菌罩、气锁间、更衣室、屏障隔离区、工艺设备及管道系统中的坚硬、非孔状表面。
经设计，产品的使用溶液可以在简单一步操作中同时起到清洁、消毒和除臭的作用。
另外，产品的非碱性配方能够清除肥皂泡沫及硬水垢，从而减少细菌滋生。
本产品适用于可耐洗的坚硬、非孔状表面，例如地板、墙面、柜台、工具、推车，以及其他设备，包括：食品加工服务的设施，动物和鸟类的饲养设施，畜禽和饲料的加工设施，兽医诊所、动物研究的设施，制药、生物技术、医疗的设施以及FDA 管制的设施。
杀细菌性：用400ppm的A.O.A.C.硬水，将产品制成1：256（0.5盎司每加仑）且含血清量为5%的溶液。
在20℃10分钟的条件下，该溶液通过了A.O.A.C.的杀菌使用稀释度的测试（实验菌种为金黄色葡萄球菌、沙门菌、铜绿假单胞菌）。
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
Inhibitors, Agonists, Screening Libraries
Data Sheet
BIOLOGICAL ACTIVITY:
RG108 is a non–nucleoside inhibitor of DNA methyltransferase with IC 50 of 115 nM.
IC50 & Target: IC50: 115 nM (DNA methyltransferase)
In Vitro: RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines.Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences [1]. In another study, the synthesis and in vitro analysis of a biotinylated RG108conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes [2]. In a recent study, it is shown RG108
can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs [3].PROTOCOL (Extracted from published papers and Only for reference)
Kinase Assay:[1]The substrate DNA for the in vitro methylation assay is a 798 bp fragment (-423/+375 relative to the initiation codon)from the promoter region of the human p16Ink4a gene. The methylation reaction contains 350 to 400 ng substrate DNA and 4 units of M.SssI methylase (0.5 μM) in a final volume of 50 μL. Inhibitors are added to final concentrations of 10, 100, 200, and 500 μM,
respectively. Reactions are done at 37°C for 2 hours. After completion, the reaction is inactivated at 65°C for 15 minutes and the DNA is purified using PCR Purification kit. Three hundred nanograms of purified DNA is digested for 3 hours at 60°C with 30 units of BstUI and analyzed on 2% Tris–borate EDTA agarose gels.
References:
[1]. Brueckner B, et al. Epigenetic reactivation of tumor suppressor genes by a novel small–molecule inhibitor of human DNA methyltransferases. Cancer Res.2005 Jul 15;65(14):6305–11.
[2]. Schirrmacher E, et al. Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug Chem. 2006 Mar–Apr;17(2):261–6.
[3]. Pasha Z, et al. Efficient non–viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells. PLoS One.2011;6(8):e23667.
Product Name:
RG108Cat. No.:
HY-13642CAS No.:
48208-26-0Molecular Formula:
C 19H 14N 2O 4Molecular Weight:
334.33Target:
DNA Methyltransferase Pathway:
Epigenetics Solubility:
10 mM in DMSO
Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@
Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。