Research on the microstructural refinement of sulfur in medium carbon microalloyed steel
微小RNA对肿瘤微环境T细胞免疫调节作用研究的新进展
doi：10.3969/j.issn.l000484X.2020.24.021微小RNA对肿瘤微环境T细胞免疫调节作用研究的新进展杨秋玲刘朝奇①汪玉玲张丽轩李志英(三峡大学附属仁和医院妇产科，宜昌443000)中图分类号R730.3文献标志码A文章编号1000-484X(2020)24-3055-05[摘要]微小RNA(miRNA)是一类新近发现的小的、内源性的、进化上高度保守的单链非编码RNA,主要在基因表达的转录后水平起作用。
自第1个miRNA被发现以来，至今已发现并通过实验验证的与人类遗传信息相关的miRNAs超过500个，这些miRNAs涉及多种细胞的生理病理过程。
尤其是miRNAs对肿瘤微环境中T细胞介导的抗肿瘤免疫应答的调控作用，已成为近年来研究者们关注的焦点。
miRNAs的靶网络是庞大且复杂的，涉及多种信号分子和信号通路。
本文分别从调节/抑制T细胞、辅助T细胞及细胞毒性T细胞3个T细胞亚群综述了miRNAs对肿瘤微环境中T细胞的免疫调节作用。
[关键词]微小RNA；肿瘤；调节/抑制T细胞;辅助T细胞；细胞毒性T细胞New advances in study of immunomodulatory effects of microRNA on T cells in tumor microenvironmentYANG Qiu-Ling,LIU Zhao-Qi,WANG Yu-Ling,ZHANG Li-Xuan,LI Zhi-Ying.Department of Gynaecology and Obstetrics, Ren-he Hospital,Affiliated of China Three Gorges University,Yichang443000,China[Abstract]MicroRNA(miRNA)is a newly discovered small,endogenous,evolutionarily highly conserved single-strand noncoding RNA,which plays a key regulatory role at post-transcriptional level of gene expression.Since the first miRNA was discovered, more than500miRNAs related to human genetic information have been discovered and verified by experiments,and these miRNAs are involved in a variety of cellular physiological and pathological processes.In particular,regulatory effect of miRNAs on T cell mediated anti-tumor immune response in tumor microenvironment has become the focus of researchers in recent years.The target network of miRNAs is large and complex,involving a variety of signal molecules and signaling pathways.In this paper,the immunomodulatory effects of miRNAs on T cell in tumor microenvironment were reviewed from3T cell subsets including regulatory/suppressor T cell, helper T cell and cytotoxic T cell.[Key words]miRNA；Tumor；Regulatory/suppressor T cell；Helper T cell；Cytotoxic T cell根据GLOBOCAN数据库估计,2018年全球新增癌症病例约为1810万例，因癌症死亡人数约为960万［l］o众所周知，现今社会的医疗水平并不能对中晚期癌症患者有很好的治疗效果，并可能令癌细胞对放化疗药物产生耐药性。
当表面活性剂遇到大环分子
114Univ. Chem. 2023, 38 (12), 114–119收稿：2023-06-27；录用：2023-08-01；网络发表：2023-08-11*通讯作者，Email:*****************.cn基金资助：2021年基础学科拔尖学生培养计划2.0研究课题(20211014)；天津市首批虚拟教研室试点建设项目(化学类交叉人才培养课程建设虚拟教研室)•专题• doi: 10.3866/PKU.DXHX202306051 当表面活性剂遇到大环分子阮文娟，李悦，耿文超，郭东升*南开大学化学学院，天津 300071摘要：近年来，表面和胶体化学与大环化学的结合引起了科学家的普遍关注。
将多样的大环结构引入表面活性剂分子，不仅极大地丰富了表面活性剂分子的种类，还可以赋予其大环的主客体识别功能。
由此所开发出的大环两亲和超两亲分子已在生物成像和药物递送中表现出很高的应用潜力。
从传统表面活性剂到大环两亲和超两亲分子的发展、应用表明，不同领域的交叉融合对科学研究的发展是非常重要的。
关键词：表面活性剂；胶束；大环结构；大环两亲分子；超两亲分子中图分类号：G64；O6Encountering of Surfactants with Macrocyclic MoleculesWen-Juan Ruan, Yue Li, Wen-Chao Geng, Dong-Sheng Guo *College of Chemistry, Nankai University, Tianjin 300071, China.Abstract: In recent years, the combination of surface and colloid chemistry with macrocyclic chemistry has garnered widespread attention among scientists. The integration of diverse macrocyclic structures into surfactant molecules not only greatly enriches the diversity of surfactants, but also imparts them with the host-guest recognition functionality of macrocycles. Macrocyclic amphiphiles and supra-amphiphiles, developed from this approach, have demonstrated high potential in applications such as bioimaging and drug delivery. The evolution from traditional surfactants to macrocyclic amphiphiles and supra-amphiphiles underscores the importance of interdisciplinary integration in advancing scientific research.Key Words: Surfactants; Micelles; Macrocycles; Macrocyclic amphiphiles; Supra-amphiphiles表面活性剂及其所构筑的胶束是表面和胶体化学中所涉及的一类非常重要的体系。
关于抗衰老研究进展的英文原文文献
Aging by Telomere Loss Can Be ReversedBruno Bernardes de Jesus 1and Maria A.Blasco 1,*1Telomeresand Telomerase Group,Molecular Oncology Program,Spanish National Cancer Centre (CNIO),Melchor Ferna´ndez Almagro 3,Madrid E-28029,Spain*Correspondence:mblasco@cnio.es DOI 10.1016/j.stem.2010.12.013Recently in Nature ,Jaskelioff et al.(2010)demonstrated that multiple aging phenotypes in a mouse model of accelerated telomere loss can be reversed within 4weeks of reactivating telomerase.This raises the major question of whether physiological aging,likely caused by a combination of molecular defects,may also be reversible.Accumulation of short/damaged telo-meres with increasing age is considered one of the main sources of aging-associ-ated DNA damage responsible for the loss of regenerative potential in tissues and during systemic organismal aging (Harley et al.,1990;Flores et al.,2005).Mounting evidence suggests that telome-rase is a longevity gene that functions by counteracting telomere attrition.Thus,telomerase-deficient mice age prema-turely,and telomerase overexpression results in extended longevity in mice (Tomas-Loba et al.,2008).Moreover,human mutations in telomerase compo-nents produce premature adult stem cell dysfunction and decreased longevity (Mitchell et al.,1999).Previous work had shown that restora-tion of telomerase activity in mouse zygotes with critically short telomeres,owing to a deficiency in the telomerase RNA component (Terc),rescues critically short telomeres and chromosomal instability in the resulting mice (Samper et al.,2001).Restoration of telomerase activity in zygotes also pre-vented the wide range of degenerative pathologies that would otherwise appear in telomerase-deficient mice with critically short telomeres,including bone marrow apla-sia,intestinal atrophy,male germ line depletion,and adult stem cell dysfunction (Samper et al.,2001;Siegl-Cachedenier et al.,2007),and resulted in a normal organismal life-span (Siegl-Cachedenier et al.,2007).Together,all the above find-ings indicate that aging provoked by crit-ical telomere shortening can be prevented or delayed by telomerase reactivation.From these grounds,reversion of aging caused by telomere loss was the next frontier.A recent study in Nature takes an important step forward from these previous findings by using a new mouse model for telomerase deficiency,de-signed to permit telomerase reactivation in adult mice after telomere-induced aging phenotypes have been established (Jas-kelioff et al.,2010).Specifically,DePinho and colleagues generated a knockin allele encoding a 4-OH tamoxifen (4-OHT)-inducible mouse telomerase (TERT-ER)under the control of the TERT endogenous promoter.In the absence of tamoxifen,these mice exhibit premature appearance of aging pathologies and reduction in survival (Figure 1).These mice phenocopy previously described Terc -deficient mice,which highlights that elongation of short telomeres by telomerase is the main mechanism by which telomerase protects from aging pathologies.Importantly,4weeks of tamoxifen treatment to induce TERT re-expression in adult TERT-ER mice with clear signs of premature aging was sufficient to extend their telomeres and rescue telomeric DNA damage signaling and associated check-point responses.Dramatically,tamox-ifen-induced TERT re-expression also led to resumption of proliferation in quies-cent cultured cells and eliminated the degenerative phenotypes across multiple organs,including testis,spleen,and intes-tines (Figure 1).Reactivation of telome-rase also ameliorated the decreased survival of TERT-ER mice.These findings represent an important advance in the aging field,as they show that aging induced by telomere loss can be reversed in a broad range of tissues and cell types,including neuronal function.Looking to the future,the next key question is to whatextent natural,physiological aging is caused by the pres-ence of critically short telo-meres and,consequently,to what extent telomere restora-tion will be able to reverse physiological aging.In this re-gard,other recent findings support the idea that telomere shortening does impactnatural mouse aging.On onehand,despite the long-standing belief that mouseaging was not linked to telo-mere shortening giventhat Figure 1.Antiaging Effects of Telomerase Schematic showing the major findings of Jaskelioff et al.(2010).Telomerasereactivation in late generation telomerase-deficient mice (G4TERT-ER )couldrevert some of the aging phenotypes observed,demonstrating the regenera-tive potential capacity of different tissues.Cell Stem Cell 8,January 7,2011ª2011Elsevier Inc.3Cell Stem CellPreviewsmice are born with very long telomeres—much longer than human telomeres—mouse telomeres do suffer extensive shortening associated with aging(Flores et al.,2008).In particular,while mouse cells maintain relatively long telomeres during theirfirst year of life,there is a dramatic loss of telomeric sequences at2years of age,even in various stem cell populations, and this change is concomitant with the loss of regenerative capacity associated with mouse aging.In addition,telome-rase-deficient mice from thefirst genera-tion(G1TercÀ/À)exhibit a significant decrease in median and maximum longevity and a higher incidence of age-related pathologies and stem cell dysfunc-tion compared with wild-type mice(Flores et al.,2005;Garcia-Cao et al.,2006),indi-cating that,as in humans,telomerase activity is rate limiting for natural mouse longevity and aging.These results suggest that strategies aimed to increase telome-rase activity may delay natural mouse aging.Further supporting this notion,it was recently shown that overexpression of TERT in the context of mice engineered to be cancer resistant owe to increase expression of tumor suppressor genes(Sp53/Sp16/SARF/TgTERT mice)wassufficient to decrease telomere damagewith age,delay aging,and increase medianlongevity by40%(Tomas-Loba et al.,2008).However,it remains to be seenwhether telomerase reactivation late in lifewould be sufficient to delay natural mouseaging and extend mouse longevity withoutincreasing cancer incidence.In summary,these proof-of-principlestudies using genetically modified miceare likely to encourage the developmentof targeted therapeutic strategies basedon reactivation of telomerase function.Indeed,small molecule telomerase acti-vators have been reported recently andhave demonstrated some preliminaryhealth-span beneficial effects in humans(Harley et al.,2010).Identifying drugabletargets and candidate activators clearlyopens a new window for the treatment ofage-associated degenerative diseases.REFERENCESFlores,I.,Cayuela,M.L.,and Blasco,M.A.(2005).Science309,1253–1256.Flores,I.,Canela,A.,Vera,E.,Tejera,A.,Cotsare-lis,G.,and Blasco,M.A.(2008).Genes Dev.22,654–667.Garcia-Cao,I.,Garcia-Cao,M.,Tomas-Loba,A.,Martin-Caballero,J.,Flores,J.M.,Klatt,P.,Blasco,M.A.,and Serrano,M.(2006).EMBO Rep.7,546–552.Harley, C.B.,Futcher, A.B.,and Greider, C.W.(1990).Nature345,458–460.Harley, C.B.,Liu,W.,Blasco,M.,Vera, E.,Andrews,W.H.,Briggs,L.A.,and Raffaele,J.M.(2010).Rejuvenation Res.14,in press.Publishedonline September7,2010.10.1089/rej.2010.1085.Jaskelioff,M.,Muller,F.L.,Paik,J.H.,Thomas,E.,Jiang,S.,Adams,A.C.,Sahin,E.,Kost-Alimova,M.,Protopopov,A.,Cadinanos,J.,et al.(2010).Nature.10.1038/nature09603.Mitchell,J.R.,Wood,E.,and Collins,K.(1999).Nature402,551–555.Samper,E.,Flores,J.M.,and Blasco,M.A.(2001).EMBO Rep.2,800–807.Siegl-Cachedenier,I.,Flores,I.,Klatt,P.,andBlasco,M.A.(2007).J.Cell Biol.179,277–290.Tomas-Loba, A.,Flores,I.,Fernandez-Marcos,P.J.,Cayuela,M.L.,Maraver,A.,Tejera,A.,Borras,C.,Matheu,A.,Klatt,P.,Flores,J.M.,et al.(2008).Cell135,609–622.HGPS-Derived iPSCs For The AgesTom Misteli1,*1National Cancer Institute,NIH,Bethesda,MD20892,USA*Correspondence:mistelit@DOI10.1016/j.stem.2010.12.014In this issue of Cell Stem Cell,Zhang et al.(2011)generate patient-derived iPSCs for one of the major prema-ture aging diseases,Hutchinson-Gilford Progeria Syndrome(HGPS).These cells are a much-needed new tool to study HGPS,and their use may lead to novel insights into mechanisms of aging.Some problems in biology are more difficult to study than others.Human aging is certainly one of them.Most conclusions regarding molecular mecha-nism of human aging rely on mere correla-tion,and direct experimental testing is generally not feasible.One approach to dissect the molecular basis of human aging is to study naturally occurring premature aging disorders.One of the most dramatic and prominent of such diseases is Hutchinson-Gilford ProgeriaSyndrome(HGPS).Zhang et al.(2011)now report the generation of inducedpluripotent stem cells(iPSCs)fromHGPS cells,providing a powerful newtool to unravel the molecular and physio-logical mechanisms of premature andnormal aging.HGPS is a truly remarkable disease inmany ways.To start with,it affects anunusually wide spectrum of tissues andleads to the development of highly diversesymptoms ranging from depletion ofsubcutaneous fat to loss of hair andtendon contractures.The diversity ofaffected tissues pointed early on to stemcell defects as a likely disease mecha-nism.Most relevant in patients arevascular defects and recurring strokes,which invariably are fatal in patients intheir mid-to late teens(Hennekam,2006).The disease is exceedingly rare4Cell Stem Cell8,January7,2011ª2011Elsevier Inc.Cell Stem Cell Previews。
超声微锻造辅助定向能量沉积316L_不锈钢微观组织与力学性能研究
第15卷第7期孟宝，等：镁锂合金微型热管电场辅助超塑挤压成形19and Superplastic Forming of Negative Angle Box-ShapedParts[D]. Harbin: Harbin Institute of Technology, 2017:3-14.[5] 李淼泉, 吴诗. LY12CZ铝合金在强电场中的超塑性变形[J]. 塑性工程学报, 1996, 3(3): 41-46.LI Miao-quan, WU Shi. Superlastic Deformation of LY12CZ Aluminum Alloy under an Electric Field[J].Journal of Plasticity Engineering, 1996, 3(3): 41-46. [6] 蔡春波, 高少伟, 高桂丽, 等. 脉冲电流对Al-Cu-Mn-Zr合金时效处理组织及性能的影响[J]. 金属热处理,2023, 48(4): 104-110.CAI Chun-bo, GAO Shao-wei, GAO Gui-li, et al. Effectof Pulse Current on Microstructure and Properties of Al-Cu-Mn-Zr Alloy after Aging Treatment[J]. Heat Treatment of Metals, 2023, 48(4): 104-110.[7] WANG Yao-li, WANG Guang-xin, ZHANG Ke-ke. Elec-tro-Superplastic Solid State Welding of 40Cr/QCr0.5[J].Materials, 2018, 11(7): 1153.[8] WANG Guo-feng, LI Xiao, LIU Si-yu, et al. ImprovedSuperplasticity and Microstructural Evolution of Ti2AlNbAlloy Sheet during Electrically Assisted Superplastic GasBulging[J]. The International Journal of Advanced Manufacturing Technology, 2018, 99(1): 773-787.[9] YOSHIDA H, SASAKI Y. Low Temperature and HighStrain Rate Superplastic Flow in Structural Ceramics In-duced by Strong Electric-Field[J]. Scripta Materialia, 2018, 146: 173-177.[10] 林赟, 唐国翌, 孙强, 等. Inconel690合金的电致塑性拉拔研究[J]. 热加工工艺, 2010, 39(24): 80-82.LIN Yun, TANG Guo-yi, SUN Qiang, et al. Investigationof Electro-Plastic Drawing on Inconel690 Alloy[J]. HotWorking Technology, 2010, 39(24): 80-82.[11] 刘建龙, 王效岗, 王皓悦. 微挤压模具设计[J]. 模具技术, 2016(5): 26-29.LIU Jian-long, WANG Xiao-gang, WANG Hao-yue. TheDesign of Micro Extrusion Die[J]. Die and Mould Tech-nology, 2016(5): 26-29.[12] 李细锋, 曹旭东, 王斌, 等. 钛合金电辅助塑性成形技术研究进展[J]. 航空制造技术, 2021, 64(17): 22-30.LI Xi-feng, CAO Xu-dong, WANG Bin, et al. ResearchProgress on Electrically-Assisted Plastic Forming Techn-ology of Titanium Alloy[J]. Aeronautical ManufacturingTechnology, 2021, 64(17): 22-30.[13] 蔡贇, 孙朝阳, 万李, 等. AZ80镁合金动态再结晶软化行为研究[J]. 金属学报, 2016, 52(9): 1123-1132.CAI Yun, SUN Zhao-yang, WAN Li, et al. Study on Dy-namic Recrystallization Softening Behavior of AZ80 Magnesium Alloy[J]. Acta Metallurgica Sinica, 2016, 52(9): 1123-1132.[14] ZHANG Cun-sheng, WANG Cui-xue, ZHANG Qing-you,et al. Influence of Extrusion Parameters on Microstruc-ture, Texture, and Second-Phase Particles in an Al-Mg-SiAlloy[J]. Journal of Materials Processing Technology, 2019, 270: 323-334. [15] XU Jie, ZHU Xiao-cheng, SHAN De-bin, et al. Effect ofGrain Size and Specimen Dimensions on Micro-Formingof High Purity Aluminum[J]. Materials Science and En-gineering: A, 2015, 646: 207-217.[16] CHEN Liang, ZHAO Guo-qun, YU Jun-quan, et al.Analysis and Porthole Die Design for a Multi-Hole Ex-trusion Process of a Hollow, Thin-Walled Aluminum Pro-file[J]. The International Journal of Advanced Manufac-turing Technology, 2014, 74(1): 383-392.[17] DEMIRCI H İ, EVLEN H. Effect of Extrusion Ratio onthe Wear Behaviour of Al-Si and Al-Mg Alloys[J]. Jour-nal of Alloys and Compounds, 2012, 510(1): 26-32. [18] GUAN Yan-jin, ZHANG Cun-sheng, ZHAO Guo-qun, etal. Design of a Multihole Porthole Die for AluminumTube Extrusion[J]. Materials and Manufacturing Proc-esses, 2012, 27(2): 147-153.[19] YU Zi-jian, XU Chao, MENG Jian, et al. Effects of Ex-trusion Ratio and Temperature on the Mechanical Proper-ties and Microstructure of As-Extruded Mg-Gd- Y-(Nd/Zn)-Zr Alloys[J]. Materials Science and Engineer-ing: A, 2019, 762: 138080.[20] 尹传龙, 齐凯华, 翟军, 等. 难以挤压成型的铝型材断面形状的局部优化[J]. 铝加工, 2022(5): 25-28.YIN Chuan-long, QI Kai-hua, ZHAI Jun, et al. AluminumProfile does not Apply to Local Optimization of Extru-sion[J]. Aluminium Fabrication, 2022(5): 25-28.[21] 王少华, 刘惠, 陈宗强, 等. 大型带筋薄壁圆管铝型材挤压成形数值模拟[J]. 锻压技术, 2022, 47(4): 181-189.WANG Shao-hua, LIU Hui, CHEN Zong-qiang, et al.Numerical Simulation on Extrusion Forming for LargeRibbed Thin-Walled Circular Tube Aluminum Profile[J].Forging & Stamping Technology, 2022, 47(4): 181-189. [22] PARK S Y, KIM W J. Difference in the Hot CompressiveBehavior and Processing Maps between the As-Cast andHomogenized Al-Zn-Mg-Cu (7075) Alloys[J]. Journal ofMaterials Science & Technology, 2016, 32(7): 660-670. [23] LIN Y C, XIA Yu-chi, CHEN Xiao-min, et al. Constitu-tive Descriptions for Hot Compressed 2124-T851 Aluminum Alloy over a Wide Range of Temperature andStrain Rate[J]. Computational Materials Science, 2010,50(1): 227-233.[24] LIU Yong-da, XU Jie, ZHANG Zheng-wu, et al. Mi-cro-Extrusion Process and Microstructure Evolution ofMiniature Heat Pipe in 6063 Aluminum Alloy[J]. The In-ternational Journal of Advanced Manufacturing Technol-ogy, 2022, 120(9/10): 6463-6480.[25] SELLARS C M, MCTEGART W J. On the Mechanism ofHot Deformation[J]. Acta Metallurgica, 1966, 14(9): 1136-1138.[26] DONATI L, TOMESANI L. The Effect of Die Design onthe Production and Seam Weld Quality of Extruded Alu-minum Profiles[J]. Journal of Materials Processing Technology, 2005, 164/165: 1025-1031.责任编辑：蒋红晨精 密 成 形 工 程第15卷 第7期20 JOURNAL OF NETSHAPE FORMING ENGINEERING2023年7月收稿日期：2023–05–29 Received ：2023-05-29基金项目：山东省重点研发项目（2021CXGC010206）Fund ：Key R&D Project of Shandong Province(2021CXGC010206) 作者简介：王硕（1997—），男，硕士生，主要研究方向为超声微锻造辅助增材制造。
循环闭式模锻制备Mg_Si合金的组织和力学性能_英文_J_METAYER
Foundation item: Projects (50674067, 51074106) supported by the National Natural Science Foundation of China; Project (2011BAE22B01-5) supported by the National Key Technologies R&D Program during the 12th Five-Year Plan Period, China; Project (09JC1408200) supported by the Science and Technology Commission of Shanghai Municipality, China Corresponding author: Qu-dong WANG; Tel: +86-21-54742715; E-mail: wangqudong@ DOI: 10.1016/S1003-6326(14)63029-6
Trans. Nonferrous Met. Soc. China 24(2014) 66−75
Microstructure and mechanical properties of Mg−Si alloys processed by cyclic closed-die forging
J. METAYER1,2, Bing YE1,3, Wei GUO1,3, Qu-dong WANG1,3, Hao ZHOU1,3, F. MOLLET1,2 1. National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240, China; 2. Arts et Métiers ParisTech engineering school, Angers, France; 3. State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China Received 1 November 2012; accepted 15 March 2013
219316036_随机质心映射优化法提升生防乳酸菌Lac9-3的粘附性及其对冷藏凡纳滨对虾（Lit
唐智鑫，钱怡霖，王荣荣，等. 随机质心映射优化法提升生防乳酸菌Lac9-3的粘附性及其对冷藏凡纳滨对虾（Litopenaeus vannamei ）菌群结构的影响[J]. 食品工业科技，2023，44（12）：130−137. doi: 10.13386/j.issn1002-0306.2022080170TANG Zhixin, QIAN Yilin, WANG Rongrong, et al. Random-Centroid Optimization (RCO) Method to Improve the Adhesion of Biocontrol Lactic Acid Bacteria (LAB) Lac 9-3 and Its Effect on the Microflora Structure of Refrigerated Litopenaeus vannamei [J].Science and Technology of Food Industry, 2023, 44(12): 130−137. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022080170· 生物工程 ·随机质心映射优化法提升生防乳酸菌Lac 9-3的粘附性及其对冷藏凡纳滨对虾（Litopenaeus vannamei ）菌群结构的影响唐智鑫，钱怡霖，王荣荣，李 苑，刘尊英*（中国海洋大学食品科学与工程学院，山东青岛 266003）摘 要：生防乳酸菌粘附是其在食品表面定植并发挥作用的第一步。
为进一步提升乳酸菌Lac 9-3在凡纳滨对虾表面的粘附性，探究其对冷藏凡纳滨对虾腐败菌生长的影响，本研究采用随机质心映射优化法（Random-Centroid Optimization ，RCO ）优化了乳酸菌Lac 9-3的接种条件（包括接种液浓度、接种菌株生长阶段、浸泡时间与接种液pH ）。
211181368_耐热线型小分子对有机硅耐温吸波涂层的增韧改性研究
第44卷 第9期 包 装 工 程2023年5月PACKAGING ENGINEERING ·81·收稿日期：2023−03−15基金项目：国家自然科学基金（52071239） 作者简介：汪君（1997—）女，硕士生。
耐热线型小分子对有机硅耐温吸波涂层的增韧改性研究汪君a ，江源源a ，熊逾玲a ，王峰a ，马会茹b ，李维a ，雷丽文a ，陈志宏c（武汉理工大学 a.材料复合新技术国家重点实验室 b.化学化工与生命学院 c.理学院，武汉 430070） 摘要：目的 采用能与有机硅单体反应的耐热小分子对苯基硅树脂基吸波涂层进行增韧改性，调控有机硅树脂的交联网络结构，并将改性树脂与耐温吸波剂复合，制备具有高柔韧、高附着力和耐温的吸波涂层。
方法 将不同端基或链长的耐热增韧剂通过硅氢加成接枝到有机硅树脂基体，改变基体的交联网络结构，通过红外、扫描电镜、万能电子试验机、动态热机械分析仪和矢量网络分析仪测试其性能。
结果 随着乙烯基封端聚二甲基硅氧烷含量的增加，涂层的柔韧性提高，但耐温性能和附着力降低；当乙烯基封端聚二甲基硅氧烷质量分数为45%时，1 mm 涂层的柔韧性达20 mm ，附着力达7.73 MPa ，抗冲击性大于50 kg·cm 。
在300 ℃热处理15 h 后，改性涂层挠度从未改性时的1.08 mm 提升至1.35 mm ，涂层在高温工作后仍保持较好的柔韧性。
结论 采用耐热线型小分子对有机硅树脂交联网络结构进行改性，可有效地调控耐温吸波涂层的力学性能，为耐高温吸波涂层增韧及其工程应用提供参考。
关键词：吸波涂层；有机硅树脂；柔韧性；附着力；耐温中图分类号：TB484.2 文献标识码：A 文章编号：1001-3563(2023)09-0081-10 DOI ：10.19554/ki.1001-3563.2023.09.010Toughening and Modification of Organic Silicone Heat-resistant Microwave AbsorbingCoatings with Heat-resistant Linear MoleculesWANG Jun a , JIANG Yuan-yuan a , XIONG Yu-ling a , WANG Feng a , MA Hui-ru b , LI Wei a ,LEI Li-wen a , CHEN Zhi-hong c(a. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing b. School of Chemistry, Chemical Engineering and Life Sciences c. School of Science, Wuhan University of Technology, Wuhan 430070, China) ABSTRACT: The work aims to control the cross-linking network structure of silicone resin by toughening and modifying the phenyl silicone resin-based microwave absorbing coating with heat-resistant small molecules that can react with or-ganic silicone monomer, and compound the modified silicone resin with heat-resistant absorbent to develop heat-resistant microwave absorbing coatings with high flexibility, high adhesion and thermal stability. Toughening modifiers with dif-ferent end groups or chain length were grafted to silicone resin by hydrosilylation addition reaction to change the cros-slinking networks of the matrix. The properties of the coatings were tested by infrared spectrum, SEM, mechanical properties and dynamic mechanical thermal analyzer. With the increase in content of vinyl-terminated poly (dimethyl siloxanes), the flex-ibility of the coating was improved, whereas the heat-resistant and adhesion were reduced. When the content of vinyl-terminated poly (dimethyl siloxanes) increased to 45 wt. %, the flexibility of the 1 mm coating reached 20 mm, with adhesion as high as 7.73 MPa and impact resistance of higher than 50 kg∙cm. After working at 300 °C for 15 h, the flexibility of the coatingincreased from 1.08 mm for unmodified coating to 1.35 mm. Moreover, the modified coatings maintained good flexibility·82·包装工程2023年5月after heat treatment. Modifying the crosslinking networks of silicone resin with heat-resistant small molecules can effec-tively control the mechanical properties of heat-resistant microwave absorbing coatings and provide references for toughening and engineering applications of heat-resistant microwave absorbing coatings.KEY WORDS: microwave absorbing coatings; silicone resin; flexibility; adhesion; heat-resistant随着电子技术的扩展[1]，微波探测技术在20世纪后期得到了快速发展[2]。
SCI收录的《中国神经再生研究(英文版)》(NRR)杂志
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