Cevimeline_107233-08-9_DataSheet_MedChemExpress
Honeywell TR21、TR22、TR23、TR24 壁模块说明书
INSTALLATION INSTRUCTIONS62-0267-09TR21, TR22, TR23, and TR24 Wall ModulesFEATURESThe TR21, TR22, TR23, and TR24 family of wall modules include:•Models with setpoint adjustment.•Models with humidity output.•Models with occupied/unoccupied override (bypass) with LED.•Models with 3-position (auto/0/1) or 5-position (auto/0/1/2/3 speed) fan switch.•L ON W ORKS ® bus jack on all models except the TR21 and TR21-A models.•Locking cover on all models.•Operating range 45° to 99° F (7° to 37° C).•Models (TR22 and TR23) with user-selectabletemperature setpoint dials in Fahrenheit, Celsius, and Relative (- to +).PRODUCT DESCRIPTIONThe TR21, TR22, TR23, and TR24 are a family of direct-wired wall modules for use with:—Spyder Unitary Controllers: PUL, PVL—Excel 10 W7750, W7751a , W7752, and W7753controllers—Honeywell Excel 800, 600, 500, 100, and 80 (all fullyprogrammable) controllers —W7761 Controller—ComfortPoint LON Controllers: CP-UL, CP-VL All models have a space temperature sensor. Some models have a temperature dial, setpoint adjustment, L ON W ORKS bus jack, override (bypass) with LED, and fan switch.NOTE:Refer to the TR21, TR22, TR23, and TR24 WallModules – Specification Data , form 63-1321, for specific model features and additional information.SPECIFICATIONSModels: For specific model information, see TR21, TR22,TR23, and TR24 Wall Modules – Specification Data , form 63-1321.Environmental Ratings:•Operating Temperature: 45° to 99° F (7° to 37° C).•Shipping Temperature: -40° to 150° F (-40° to 65.5° C).Accessories: 50007298-001 (pack of 12) medium, coverplate; 6-7/8 x 5in. (175 x 127 mm).Approvals: CE; UL94 plastic enclosure; FCC Part 15, Class BTemperature SensorTR21, TR22, TR23, and TR24 20K Ohm Nonlinearized Sensor:All models are furnished with a 20K Ohm nonlinear NTC temperature sensor that follows a specific temperature resistance curve. See Fig. 1 on page 2.NOTE:The TR21-A wall module model has two (2) 20KOhm nonlinear NTC temperature sensors in parallel, which provide 10K NTC temperature sensingnecessary for averaging.a The TR21, TR22, TR23, and TR24 wall modules are notcompatible with W7751A,C,E,G Controllers.TR21, TR22, TR23, AND TR24 WALL MODULES62-0267—092Fig. 1. Temperature vs. Resistance for Nonlinear Sensor.CommunicationsAll wall modules (except the TR21 and TR21-A models) havea L ON M ARK ® bus communications port. If needed, the jack plug must be removed in the field, and terminals 3 and 4 wired according to the installation instructions.The recommended wire size for the L ON M ARK ® bus is Level IV, 22 AWG (0.34 sq.mm) plenum or non-plenum rated, non-shielded, twisted pair, solid conductor wire.Fig. 2. Wall Module Features (TR23-F Shown).BEFORE INSTALLATIONFailure to follow proper wiring practices canintroduce disruptive electrical interference (noise).Keep wiring at least one foot away from large inductive loads such as motors, line starters, lighting ballasts, and large power distribution panels.Shielded cable is required in installations where these guidelines cannot be met.Ground shild only to grounded controller case.IMPORTANTAll wiring must comply with local electrical codes and ordinances or as specified on installation wiring diagrams.—Wall module wiring can be sized from 16 to 22 AWG (1.31 to 0.33 sq. mm) depending on the application.—The maximum length of wire from a device to a wall module is 1000 ft. (305 m).—Twisted pair wire is recommended for wire runs longer than 100 ft. (30.5 m).INSTALLATIONMount the wall module on an inside wall approximately 54 in. (1372 mm) from the floor (or in the specified location) to allow exposure to the average zone temperature. Do not mount the wall module on an outside wall, on a wall containing water pipes, or near air ducts. Avoid locations that are exposed to discharge air from registers or radiation from lights,appliances, or the sun. See “Cover Disassembly” on page 3.The wall module can be mounted on a wall, on a standard utility conduit box using No. 6 (3.5 mm) screws or on a 60mm wall outlet box (see Fig.3). When mounting directly on a wall, use the type of screws appropriate for the wall material.Fig. 3. Mounting on Standard Utility Conduit Box or60 mm Wall Outlet Box (TR23 Shown).FRONT COVERTR21, TR22, TR23, AND TR24 WALL MODULES362-0267—10Fig. 4. Wall Module Subbase Dimensions in Inches (mm) and Temperature Limit Set Screw Locations (TR23Shown).Cover DisassemblyA snap-fit locking mechanism is used to attach the cover of the wall module to its subbase. To disassemble the cover from the subbase:1.Insert a thin, flat blade screwdriver into each of the twoslots at the bottom of the module to release the two locking tabs. See Fig.2 on page 2.2.Tilt the cover out and away from the subbase to releasethe top two locking tabs.3.To change the dial (e.g. from Fahrenheit to Celsius)release the two tabs on the inside of the front cover and remove the old dial.WiringAttach the wires from the device sensor terminals to the appropriate wall module terminals. See Table 1 on page4.Screw type terminal blocks are designed to accept no more than one 16 AWG (1.31 sq. mm) conductor.Connect multiple wires that are 16-18 AWG(1.31-0.82 sq. mm) with a wire nut. Include a pigtail with this wire group and attach the pigtail to the individual terminal block.Wiring Wall ModulesWire the terminal block as follows:1.For single wires, strip 3/16 in. (5 mm); for multiple wiresgoing into one terminal, strip 1/2 in. (13 mm) insulation from the conductor.2.If two or more wires (20 to 22 AWG only) are beinginserted into one terminal, twist the wires together before inserting. See Fig. 5.3.Insert the wire in the required terminal location and tighten the screw to complete the termination.4.Review and verify the terminal connection wiring and DIP switch settings illustrated in Table 1 on page 4.NOTE:Wire the Lon connection (terminals 3 and 4) usingLevel IV 22 AWG (0.34 mm 2) plenum or non-plenum rated, unshielded, twisted pair, solid conductor wire.Wiring ExamplesTable 1 on page 4 illustrates DIP switch settings and terminal connections for the wall modules. Refer to the TR21, TR22, TR23, and TR24 Wall Modules – Specification Data , form 63-1321, for additional DIP Switch information.IMPORTANTSW 2 on DIP Switch S2 is used for factory calibration of the temperature setpoint potentiometer.Depending on calibration, this switch may be set in either the On or Off position.DO NOT change the position of this switch.NOTES:1.The TR21 and TR22 models do not use DIP Switch S1 and S3.2.DIP Switch S1 is used only on the humidity models, TR21-H and TR23-H.3.Models TR21 and TR21-A use terminals 1 and 2 only. Model TR21-J uses terminals 1, 2, 3, and 4 only.Fig. 5. Attaching Two Wires (20 to 22 AWG) to Wall ModuleTerminals.Attaching the CoverWhen all wiring is complete, attach the cover of the Wall Module as follows:1.Optional : For models with a temperature dial, insert thetwo setpoint screws into the inside of the cover to set the desired temperature range limit. See Fig.4.2.Press the cover straight down onto the subbase until itsnaps into place.3.For models with a temperature dial, insert the desireddial through the opening in the cover. Align the keyed shaft on the knob with the keyed slot into the fitting on the subbase, then press down until it snaps into place.TR21, TR22, TR23, AND TR24 WALL MODULESWiring and DIP switch settings:See Table 1 to determine DIP switch positions and terminal usage for each controller.Table 1. DIP Switch Settings and Terminal Connections.62-0267—094TR21, TR22, TR23, AND TR24 WALL MODULES562-0267—09TR22 and TR23 Setpoint AdjustmentFor the TR22 and TR23 Wall Modules with a setpointadjustment, the controller must be programmed for the values in Table 2 and Table 3.TR23-KL and TR23-H-KLThe TR23-KL and TR23-H-KL ship in packs of 20 and are supplied without setpoint adjustment knobs. Knobs can be ordered separately. See Table 4 for Knob model numbers.Humidity Settings (DIP switch S1)The humidity sensing control mode is set with this 2-position DIP switch. Refer to Fig.4 on page 3 for location of DIP switch S1.NOTE:These switch settings apply only to the TR21-H andTR23-H models.To change the setting, first disconnect the power, then set SW1 and SW2 according to Table 5.TR23 and TR24 Wall Module Override (Bypass) Pushbutton and LED OperationWhen Used With Excel 10 Controllers:The Excel 10 controllers (W7750, W7751, W7752, andW7753) provide timed occupied and unoccupied temperature setpoints for the Wall Module, see Fig. 6. The override pushbutton is used to change the controller into the modes shown in Table 6 and illustrated in Fig.7 on page 6. The override (bypass) LED displays the override status of the controller.Fig. 6. LED and override pushbutton locations(TR23-F Wall Module shown).Table 2. Setpoint Values.Setpoint Value Program Setting55°F (13°C) 2.773 V 65°F (18°C) 2.148 V 75°F (24°C) 1.345 V 85°F (29°C)0.43 VTable 3. Wall Module Setpoint Configuration.Model Setpoint Resistance (Ohms)°F Absolute 55°F 957485°F1426Relative -9°F offset from 70°F 9574+9°F offset from 70°F1426°C Absolute12°C 994530°C1150Table 4. Knob Model NumbersModel DescriptionKNOB-C Celsius scale knob (pack of 20)KNOB-F Fahrenheit scale knob (pack of 20)KNOB-ORelative scale knob (pack of 20)Table 5. DIP Switch S1 Settings.Wall Module Model Sensing Control Individual Switches 12TR21-H TR23-H0-10 Vdc OFF OFF 0-5 Vdc OFF ON 4-20 mAONOFFTR21, TR22, TR23, AND TR24 WALL MODULES62-0267—096Fig. 7. Override pushbutton operation.When Used With Excel 600/500/100/80/50 Controllers:The application engineer/programmer can program theoverride (bypass) and LED to operate in any manner desired. The override (bypass) input is a dry contact, normally open, momentary digital input when the wall module does not have a fan switch. When a fan speed switch (basically a series of resistances based on fan switch position) is present, the override button is an analog input. See Table 4 for resistances.When Used With T7350 Thermostat:TR21, TR21-A, TR21-H, TR22, TR23, and TR24 are the models compatible with the T7350 thermostat. When using with the T7350 thermostat be sure to use the relative +/- offset knob only. The Celsius and Fahrenheit knobs will not work properly with the T7350 Thermostat.TR22-F5, TR23-F3, and TR23-F5 Wall Module Fan SwitchWith the switch in the far left position (Auto), the fanautomatically runs at the speed determined by the controller temperature control algorithm.With the switch in the 0 position, the fan is off. Position 1 is fan speed 1, etc.The wall module fan speed switch overrides the temperature control algorithm.When Used With Excel 10 Controllers:The Excel 10 Controllers (W7750, W7751, W7752, andW7753) can be programmed so that the fan speed switch and override button function the way that the application engineer/programmer wants. See Table 7 for controller-programming resistances. Switch 1 on Dip Switch S2 adds 10k Ohms resistance when OPEN (for Excel 600-80 controllers) and removes it when CLOSED (for Excel 10 controllers).When Used With Excel 600/500/100/80/50 Controllers:Excel 600/500/100/80 Controllers can be programmed so that the fan speed switch and override button function the way that the application engineer/programmer wants. See Table 8 for controller-programming resistances. Switch 1 on Dip Switch S2 adds 10k Ohms resistance when OPEN (for Excel 600-80 controllers) and removes it when CLOSED (for Excel 10 controllers).Table 6. Wall Module Operation.Pushbutton Held Down Controller Model LED Status0 to 1 second No override Off 1 to 4 seconds Timed occupied override On4 to 7 seconds Unoccupied override Single blink per secondLonger than 7 seconds No overrideOffnot applicableContinuous occupied override aaRemote function, which is generated from the network.Two blinks per secondTable 7. Program Settings for Wall Modules withFan Switch using Excel 10 Controllers.For Switch Position Resistance (Ohms)Comment Auto 1861 ±119Left most position 02686 ±127Fan Off position13866 ±13923041 ±13034601 ±146Right most positionOverride button closed Closed circuitTable 8. Program Settings for Wall Modules with Fan Switch using Excel 600/500/100/80 Controllers.For Switch Position Resistance (Ohms)Comment Auto 11.861K ±119Left most position 012.686K ±127Fan Off position113.866K ±139213.04K ±130314.60K ±146Right most positionOverride button closed 10K ±100TR21, TR22, TR23, AND TR24 WALL MODULES 762-0267—09TR21, TR22, TR23, AND TR24 WALL MODULESAutomation and Control Solutions Honeywell International Inc.Honeywell Limited-Honeywell Limitée 1985 Douglas Drive North 35 Dynamic DriveGolden Valley, MN 55422Toronto, Ontario M1V 4Z9® U.S. Registered Trademark© 2009 Honeywell International Inc.62-0267—09E.K. Rev. 09-09L ON W ORKS ® is a registered trademark of Echelon ® Corporation.L ON M ARK ® and the LonMark Logo are trademarks of the LonMark Association.By using this Honeywell literature, you agree that Honeywell will have no liability for any damages arising out of your use or modification to, the literature. You will defend and indemnify Honeywell, its affiliates and subsidiaries, from and against any liability, cost, or damages, including attorneys’ fees, arising out of, or resulting from, any modification to the literature by you.。
碧云天生物技术 Beyotime Biotechnology 生物素标记EMSA探针说明书
碧云天生物技术/Beyotime Biotechnology订货热线：400-168-3301或800-8283301订货e-mail：******************技术咨询：*****************网址：碧云天网站微信公众号生物素标记EMSA探针－β-Catenin/TCF (0.2μM)产品编号产品名称包装GS018B 生物素标记EMSA探针－β-Catenin/TCF (0.2µM) 200µl产品简介：生物素标记EMSA探针－β-Catenin/TCF是用于EMSA(也称gel shift)研究的生物素(Biotin)标记的β-Catenin/TCF consensus oligonucleotide。
这个生物素标记的双链寡核苷酸含有公认的β-Catenin/TCF结合位点，可以用作EMSA研究时的探针。
β-Catenin/TCF consensus oligo的序列如下：5'-CCC TTT GAT CTT ACC-3'3'-GGG AAA CTA GAA TGG-5'本生物素标记EMSA探针已经过纯化，可以直接用于EMSA结合反应。
本生物素标记EMSA探针可以和碧云天的化学发光法EMSA试剂盒(GS009)配套使用。
一个包装的生物素标记探针可以进行约200-400个样品的EMSA检测。
包装清单：产品编号产品名称包装GS018B 生物素标记EMSA探针－β-Catenin/TCF (0.2µM) 200µl—说明书1份保存条件：-20ºC保存，一年有效。
注意事项：避免加热到40ºC以上，温度过高会导致双链DNA探针解聚成单链。
而单链无法用于EMSA研究。
对于基于生物素标记的EMSA检测的详细操作可以参考碧云天的化学发光法EMSA试剂盒(GS009)的使用说明。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
Mercon ULV自动变速箱油产品说明说明书
SAFETY DATA SHEET1. IdentificationMERCON ULV AUTOMATIC TRANSMISSION FLUIDProduct identifierOther means of identification196825FIR No.Automatic Transmission FluidRecommended useNone known.Recommended restrictionsManufacturer/Importer/Supplier/Distributor informationFord Motor CompanyCompany NameAttention: SDS Information, P.O. Box 1899AddressDearborn, Michigan 48121USA1-800-392-3673Telephone1-800-448-2063 (USA and Canada)SDS InformationEmergency telephonenumbersPoison Control Center: USA and Canada: 1-800-959-3673INFOTRAC (Transportation): USA and Canada 1-800-535-50532. Hazard(s) identificationNot classified.Physical hazardsAspiration hazardCategory 1Health hazardsNot classified.Environmental hazardsNot classified.OSHA defined hazardsLabel elementsSignal word DangerHazard statement May be fatal if swallowed and enters airways.Precautionary statementPrevention Observe good industrial hygiene practices.Response If swallowed: Immediately call a poison center/doctor. Do NOT induce vomiting. Take offcontaminated clothing and wash it before reuse.Storage Store locked up.Disposal Dispose of contents/container in accordance with local/regional/national/international regulations. Hazard(s) not otherwiseNone known.classified (HNOC)Supplemental information None.3. Composition/information on ingredientsMixturesCAS number% Chemical name Common name and synonyms89 - 90Distillates (petroleum), hydrotreated64742-55-8light paraffinicSpecific chemical identity and/or exact percentage (concentration) of composition has been withheld as a trade secret.4. First-aid measuresMove to fresh air. Call a physician if symptoms develop or persist.Inhalation Wash off with soap and water. Get medical attention if irritation develops and persists.Skin contact Rinse with water. Get medical attention if irritation develops and persists.Eye contact Call a physician or poison control center immediately. Rinse mouth. Do not induce vomiting. If vomiting occurs, keep head low so that stomach content doesn't get into the lungs.IngestionAspiration may cause pulmonary edema and pneumonitis.Most importantsymptoms/effects, acute and delayedProvide general supportive measures and treat symptomatically. Keep victim under observation.Symptoms may be delayed.Indication of immediatemedical attention and special treatment needed Ensure that medical personnel are aware of the material(s) involved, and take precautions to protect themselves.General information5. Fire-fighting measuresWater fog. Foam. Dry chemical powder. Carbon dioxide (CO2).Suitable extinguishing media Do not use water jet as an extinguisher, as this will spread the fire.Unsuitable extinguishing mediaDuring fire, gases hazardous to health may be formed. Upon decomposition, this product emits carbon monoxide, carbon dioxide and/or low molecular weight hydrocarbons.Specific hazards arising from the chemicalSelf-contained breathing apparatus and full protective clothing must be worn in case of fire.Special protective equipment and precautions for firefighters Move containers from fire area if you can do so without risk.Fire fightingequipment/instructions Use standard firefighting procedures and consider the hazards of other involved materials.Specific methods No unusual fire or explosion hazards noted.General fire hazards6. Accidental release measuresAvoid contact with eyes, skin, and clothing. Avoid inhalation of vapors and spray mists. Ensure adequate ventilation. Keep people away from and upwind of spill/leak. Keep unnecessarypersonnel away. Local authorities should be advised if significant spillages cannot be contained.Wear appropriate protective equipment and clothing during clean-up. For personal protection, see section 8 of the SDS.Personal precautions,protective equipment and emergency proceduresThe product is immiscible with water and will spread on the water surface.Large Spills: Stop the flow of material, if this is without risk. Dike the spilled material, where this is possible. Absorb in vermiculite, dry sand or earth and place into containers. Following product recovery, flush area with water.Small Spills: Wipe up with absorbent material (e.g. cloth, fleece). Clean surface thoroughly to remove residual contamination.Never return spills to original containers for re-use. For waste disposal, see section 13 of the SDS.Methods and materials for containment and cleaning upAvoid discharge into drains, water courses or onto the ground.Environmental precautions7. Handling and storageAvoid contact with eyes, skin, and clothing. Avoid breathing mist or vapor. Avoid prolongedexposure. Provide adequate ventilation. Observe good industrial hygiene practices. Wash hands thoroughly after handling. Wear appropriate personal protective equipment. For personal protection, see Section 8 of the SDS.Precautions for safe handlingStore locked up. Store in tightly closed container. Store away from incompatible materials (see Section 10 of the SDS).Conditions for safe storage,including any incompatibilities8. Exposure controls/personal protectionOccupational exposure limitsThe following constituents are the only constituents of the product which have a PEL, TLV or other recommended exposure limit.At this time, the other constituents have no known exposure limits.US. OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000)Form Value Components Type PEL5 mg/m3Mist.Distillates (petroleum),hydrotreated light paraffinic (CAS 64742-55-8)US. ACGIH Threshold Limit Values FormValue ComponentsType TWA5 mg/m3Inhalable fraction.Distillates (petroleum),hydrotreated light paraffinic (CAS 64742-55-8)US. NIOSH: Pocket Guide to Chemical Hazards Form Value Components Type STEL10 mg/m3Mist.Distillates (petroleum),hydrotreated light paraffinic (CAS 64742-55-8)TWA 5 mg/m3Mist.No biological exposure limits noted for the ingredient(s).Biological limit values Use adequate ventilation to control airborne concentrations below the exposure limits/guidelines. If user operations generate a vapor, dust and/or mist, use process enclosure, appropriate local exhaust ventilation, or other engineering controls to control airborne levels below the recommended exposure limits/guidelines.Appropriate engineering controlsIndividual protection measures, such as personal protective equipmentWear safety glasses with side shields (or goggles).Eye/face protectionSkin protectionSuitable chemical protective gloves should be worn when the potential exists for skin exposure.The choice of an appropriate glove does not only depend on its material but also on other quality features and is different from one producer to the other. Nitrile gloves are recommended.Hand protectionWear appropriate chemical resistant clothing if applicable.OtherIf engineering controls do not maintain airborne concentrations to a level which is adequate to protect worker health, an approved respirator must be worn. Respirator selection, use and maintenance should be in accordance with the requirements of OSHA Respiratory Protection Standard 29 CFR 1910.134 and/or Canadian Standard CSA Z94.4.Respiratory protectionWear appropriate thermal protective clothing, when necessary.Thermal hazards Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing and protective equipment to remove contaminants.General hygiene considerations9. Physical and chemical propertiesAppearanceLiquid.Physical state Liquid.Form Red.Color PETROLEUM OdorOdor threshold Not available.pHNot available.Melting point/freezing point Not available.Initial boiling point and boiling range Not available.Flash point > 314.6 °F (> 157.0 °C) Pensky-Martens Closed Cup Evaporation rate Not available.Not applicable.Flammability (solid, gas)Upper/lower flammability or explosive limits Explosive limit - lower (%)Not available.Explosive limit - upper (%)Not available.Vapor pressure< 1 mm HgVapor density > 1 (Air=1)Relative density0.83 - 0.85 (Water=1)Relative density temperature 60.08 °F (15.6 °C)Solubility(ies)Solubility (water)Negligible Partition coefficient (n-octanol/water)Not available.Auto-ignition temperature Not available.Decomposition temperature Not available.Viscosity19 - 20 cSt Viscosity temperature104 °F (40 °C)10. Stability and reactivityThe product is stable and non-reactive under normal conditions of use, storage and transport.Reactivity Material is stable under normal conditions.Chemical stability No dangerous reaction known under conditions of normal use.Possibility of hazardous reactionsContact with incompatible materials.Conditions to avoid Strong oxidizing agents.Incompatible materials Upon decomposition, this product emits carbon monoxide, carbon dioxide and/or low molecular weight hydrocarbons.Hazardous decomposition products11. Toxicological informationInformation on likely routes of exposureInhalationBased on available data, the classification criteria are not met. Prolonged inhalation may be harmful.Skin contact Based on available data, the classification criteria are not met.Eye contact Based on available data, the classification criteria are not met.IngestionDroplets of the product aspirated into the lungs through ingestion or vomiting may cause a serious chemical pneumonia.Symptoms related to the physical, chemical andtoxicological characteristics Aspiration may cause pulmonary edema and pneumonitis.Information on toxicological effectsAcute toxicityMay be fatal if swallowed and enters airways.Prolonged skin contact may cause temporary irritation.Skin corrosion/irritation Direct contact with eyes may cause temporary irritation.Serious eye damage/eye irritationRespiratory or skin sensitizationRespiratory sensitizationNot a respiratory sensitizer.This product is not expected to cause skin sensitization.Skin sensitization No data available to indicate product or any components present at greater than 0.1% are mutagenic or genotoxic.Germ cell mutagenicity CarcinogenicityNot classifiable as to carcinogenicity to humans.IARC Monographs. Overall Evaluation of CarcinogenicityNot listed.OSHA Specifically Regulated Substances (29 CFR 1910.1001-1053)Not listed.This product is not expected to cause reproductive or developmental effects.Reproductive toxicitySpecific target organ toxicity -single exposureNot classified.Specific target organ toxicity -repeated exposureNot classified.Aspiration hazard May be fatal if swallowed and enters airways.Chronic effectsProlonged inhalation may be harmful.12. Ecological informationThe product is not classified as environmentally hazardous. However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment.EcotoxicityNo data is available on the degradability of any ingredients in the mixture. Persistence and degradabilityBioaccumulative potential No data available.Mobility in soil Other adverse effectsNo other adverse environmental effects (e.g. ozone depletion, photochemical ozone creationpotential, endocrine disruption, global warming potential) are expected from this component.13. Disposal considerationsCollect and reclaim or dispose in sealed containers at licensed waste disposal site. Dispose of contents/container in accordance with local/regional/national/international regulations. Don't pollute. Conserve resources. Return used oil to collection centers.Disposal instructionsDispose in accordance with all applicable regulations.Local disposal regulations The waste code should be assigned in discussion between the user, the producer and the waste disposal company.Hazardous waste code Dispose of in accordance with local regulations. Empty containers or liners may retain some product residues. This material and its container must be disposed of in a safe manner (see:Disposal instructions).Waste from residues / unused productsSince emptied containers may retain product residue, follow label warnings even after container is emptied. Empty containers should be taken to an approved waste handling site for recycling or disposal.Contaminated packaging14. Transport informationDOTNot regulated as dangerous goods.IATANot regulated as dangerous goods.IMDGNot regulated as dangerous goods.Not established.Transport in bulk according toAnnex II of MARPOL 73/78 and the IBC Code15. Regulatory informationThis product is a "Hazardous Chemical" as defined by the OSHA Hazard Communication Standard, 29 CFR 1910.1200.US federal regulationsToxic Substances Control Act (TSCA)TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D)Not regulated.CERCLA Hazardous Substance List (40 CFR 302.4)Not listed.SARA 304 Emergency release notificationNot regulated.OSHA Specifically Regulated Substances (29 CFR 1910.1001-1053)Not listed.SARA 302 Extremely hazardous substanceSuperfund Amendments and Reauthorization Act of 1986 (SARA)Not listed.YesSARA 311/312 Hazardous chemicalAspiration hazardClassified hazard categoriesSARA 313 (TRI reporting)Not regulated.Other federal regulationsClean Air Act (CAA) Section 112 Hazardous Air Pollutants (HAPs) ListNot regulated.Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130)Not regulated.Not regulated.Safe Drinking Water Act(SDWA)International InventoriesAll components are listed or are exempt from listing on the Toxic Substances Control Act Inventory.16. Other information, including date of preparation or last revision08-20-2021Issue date Version 01Health: 0Flammability: 1Physical hazard: 0HMIS® ratingsHealth: 0Flammability: 1Instability: 0NFPA ratingsThis document was prepared by FCSD-Toxicology, Ford Motor Company, Diagnostic Service Center II, 1800 Fairlane Drive, Allen Park, MI 48101, USA, based in part on information provided by the manufacturer. The information on this data sheet represents our current data and is accurate to the best of our knowledge as to the proper handling of this product under normal conditions and in accordance with the application specified on the packaging and/or technical guidance literature. Any other use of the product which involves using the product in combination with any other product or any other process is the responsibility of the user. To the extent that there are any differences between this product’s Safety Data Sheet (SDS) and the consumer packaged product labels, the SDS should be followed.Preparation Information and DisclaimerXT-12-QULV, XT-12-QULV1Part number(s)。
LUNA SENSATION 藻类杀菌剂数据安全表说明书
LUNA SENSATION®1/11Version 4.0 / USA Revision Date: 06/30/2020102000012886 Print Date: 06/30/2020SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKINGProduct identifierTrade nameLUNA SENSATION®Product code (UVP)84469882SDS Number102000012886EPA Registration No. 264-1090Relevant identified uses of the substance or mixture and uses advised againstUseFungicideRestrictions on useSee product label for restrictions.Information on supplierSupplier Bayer CropScience LP 800 North Lindbergh Blvd. St. Louis, MO 63167 USAResponsible DepartmentEmail: ************************Emergency telephone no.Emergency Telephone Number (24hr/ 7 days)1-800-334-7577Product Information Telephone Number 1-866-99BAYER (1-866-992-2937)SECTION 2: HAZARDS IDENTIFICATIONClassification in accordance with regulation HCS 29CFR §1910.1200 Acute toxicity(Oral): Category 4Reproductive toxicity: Effects on or via lactationLabelling in accordance with regulation HCS 29CFR §1910.1200Signal word : WarningHazard statementsHarmful if swallowed.May cause harm to breast-fed children.LUNA SENSATION®2/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 Precautionary statementsWash thoroughly after handling.Do not eat, drink or smoke when using this product.Obtain special instructions before use.Do not breathe mist.Avoid contact during pregnancy/ while nursing.IF SWALLOWED: Call a POISON CENTER/doctor/physician if you feel unwell.Rinse mouth.IF exposed or concerned: Get medical advice/ attention.Dispose of contents/container in accordance with local regulation.Hazards Not Otherwise Classified (HNOC)No physical hazards not otherwise classified.No health hazards not otherwise classified.SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTSHazardous Component Name CAS-No.Concentration % by weight Fluopyram 658066-35-4 21.4 Trifloxystrobin 141517-21-7 21.4 SECTION 4: FIRST AID MEASURESDescription of first aid measuresGeneral advice When possible, have the product container or label with you whencalling a poison control center or doctor or going for treatment.Inhalation Move to fresh air. If person is not breathing, call 911 or an ambulance,then give artificial respiration, preferably mouth-to-mouth if possible.Call a physician or poison control center immediately.Skin contact Take off contaminated clothing and shoes immediately.Wash offimmediately with plenty of water for at least 15 minutes.Call aphysician or poison control center immediately.Eye contact Hold eye open and rinse slowly and gently with water for 15-20minutes.Remove contact lenses, if present, after the first 5 minutes,then continue rinsing eye.Call a physician or poison control centerimmediately.Ingestion Call a physician or poison control center immediately.Rinse out mouthand give water in small sips to drink.DO NOT induce vomiting unlessdirected to do so by a physician or poison control center.Never giveanything by mouth to an unconscious person.Do not leave victimunattended.Most important symptoms and effects, both acute and delayedSymptoms To date no symptoms are known.Indication of any immediate medical attention and special treatment neededLUNA SENSATION®3/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 Treatment Appropriate supportive and symptomatic treatment as indicated by thepatient's condition is recommended.SECTION 5: FIREFIGHTING MEASURESExtinguishing mediaSuitable Water spray, Carbon dioxide (CO2), Alcohol-resistant foam, Sand Unsuitable High volume water jetSpecial hazards arising from the substance or mixture In the event of fire the following may be released:, Hydrogen chloride (HCl), Hydrogen cyanide (hydrocyanic acid), Hydrogen fluoride, Carbon monoxide (CO), Carbon dioxide (CO2), Nitrogen oxides (NOx)Advice for firefightersSpecial protective equipment for firefighters Firefighters should wear NIOSH approved self-contained breathing apparatus and full protective clothing.Further information Keep out of smoke. Fight fire from upwind position. Cool closedcontainers exposed to fire with water spray. Do not allow run-off fromfire fighting to enter drains or water courses.Flash point> 100 °CAuto-ignition temperature 380 °C / 716 °FLower explosion limit No data availableUpper explosion limit No data availableExplosivity Not explosive92/69/EEC, A.14 / OECD 113SECTION 6: ACCIDENTAL RELEASE MEASURESPersonal precautions, protective equipment and emergency proceduresPrecautions Keep unauthorized people away. Isolate hazard area. Avoid contactwith spilled product or contaminated surfaces.Methods and materials for containment and cleaning upMethods for cleaning up Soak up with inert absorbent material (e.g. sand, silica gel, acidbinder, universal binder, sawdust). Clean contaminated floors andobjects thoroughly, observing environmental regulations. Collect andtransfer the product into a properly labelled and tightly closedcontainer.Additional advice Use personal protective equipment. If the product is accidentallyspilled, do not allow to enter soil, waterways or waste water canal.LUNA SENSATION®4/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 Reference to other sections Information regarding safe handling, see section 7.Information regarding personal protective equipment, see section 8.Information regarding waste disposal, see section 13.SECTION 7: HANDLING AND STORAGEPrecautions for safe handlingAdvice on safe handling Use only in area provided with appropriate exhaust ventilation. Handleand open container in a manner as to prevent spillage.Hygiene measures Wash hands thoroughly with soap and water after handling and beforeeating, drinking, chewing gum, using tobacco, using the toilet orapplying cosmetics.Remove Personal Protective Equipment (PPE) immediately afterhandling this product. Before removing gloves clean them with soap andwater. Remove soiled clothing immediately and clean thoroughly beforeusing again. Wash thoroughly with soap and water after handling. Conditions for safe storage, including any incompatibilitiesRequirements for storage areas and containers Store in a cool, dry place and in such a manner as to prevent cross contamination with other crop protection products, fertilizers, food, and feed. Store in original container and out of the reach of children, preferably in a locked storage area. Protect from freezing. Keep away from direct sunlight.SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTIONControl parameters*OES BCS: Internal Bayer AG, Crop Science Division "Occupational Exposure Standard"Exposure controlsPersonal protective equipmentIn normal use and handling conditions please refer to the label and/or leaflet. In all other cases the following recommendations would apply.Respiratory protection When respirators are required, select NIOSH approved equipmentbased on actual or potential airborne concentrations and inaccordance with the appropriate regulatory standards and/or industryrecommendations.Hand protection Chemical resistant nitrile rubber glovesEye protection Safety glasses with side-shieldsLUNA SENSATION®5/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 Skin and body protection Wear long-sleeved shirt and long pants and shoes plus socks. General protective measures Follow manufacturer's instructions for cleaning/maintaining PPE. Ifno such instructions for washables, use detergent and warm/tepidwater.Keep and wash PPE separately from other laundry.SECTION 9. PHYSICAL AND CHEMICAL PROPERTIESAppearance white to beigePhysical State suspensionOdor characteristicOdour Threshold No data availablepH 5.0 - 8.0 (100 %) (23 °C)Viscosity, kinematic No data availableVapor Pressure No data availableVapor Density (Air = 1)No data availableDensity ca. 1.17 g/cm³ (20 °C)Evaporation rate No data availableBoiling Point No data availableMelting / Freezing Point No data availableWater solubility suspensiveMinimum Ignition Energy Not applicableDecompositionStable under normal conditions.temperatureSelf-accelaratingNo data availabledecomposition temperature(SADT)Partition coefficient: n-Not applicableoctanol/waterViscosity240 - 350 mPa.s (20 °C) Velocity gradient 20 /sFlammability No data availableOxidizing properties No oxidizing propertiesFlash point> 100 °CAuto-ignition temperature 380 °C / 716 °FLower explosion limit No data availableUpper explosion limit No data availableLUNA SENSATION®6/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 Explosivity Not explosive92/69/EEC, A.14 / OECD 113Particle size No data availableOther information Further safety related physical-chemical data are not known.SECTION 10: STABILITY AND REACTIVITYReactivityThermal decomposition Stable under normal conditions.Chemical stability Stable under recommended storage conditions.Possibility of hazardous reactions No hazardous reactions when stored and handled according to prescribed instructions.Conditions to avoid Extremes of temperature and direct sunlight.Incompatible materials No incompatible materials known.Hazardous decompositionproductsNo decomposition products expected under normal conditions of use. SECTION 11: TOXICOLOGICAL INFORMATIONExposure routes Skin Absorption, Ingestion, Inhalation, Eye contactImmediate EffectsSkin Harmful if absorbed through skin.Ingestion Harmful if swallowed.Inhalation Harmful if inhaled.Information on toxicological effectsAcute oral toxicity LD50 (female Rat) 2,000 mg/kgAcute inhalation toxicity LC50 (Rat) > 1.7 mg/lExposure time: 4 hDetermined in the form of liquid aerosol.Highest attainable concentration.No deathsAcute dermal toxicity LD50 (Rat) > 2,000 mg/kgSkin corrosion/irritation No skin irritation (Rabbit)Serious eye damage/eyeirritationNo eye irritation (Rabbit)LUNA SENSATION®7/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020Respiratory or skin sensitisation Skin: Non-sensitizing. (Mouse)OECD Test Guideline 429, local lymph node assay (LLNA)Assessment STOT Specific target organ toxicity – single exposureFluopyram: Based on available data, the classification criteria are not met.Trifloxystrobin: Based on available data, the classification criteria are not met.Assessment STOT Specific target organ toxicity – repeated exposureFluopyram did not cause specific target organ toxicity in experimental animal studies.Trifloxystrobin did not cause specific target organ toxicity in experimental animal studies.Assessment mutagenicityFluopyram was not mutagenic or genotoxic in a battery of in vitro and in vivo tests.Trifloxystrobin was not mutagenic or genotoxic in a battery of in vitro and in vivo tests.Assessment carcinogenicityFluopyram caused at high dose levels an increased incidence of tumours in rats in the followingorgan(s): Liver.Fluopyram caused at high dose levels an increased incidence of tumours in mice in the followingorgan(s): Thyroid.The tumours seen with Fluopyram were caused through a non-genotoxic mechanism, which is not relevant at low doses. The mechanism that triggers these tumours is not relevant to humans. Trifloxystrobin was not carcinogenic in lifetime feeding studies in rats and mice.ACGIHNone.NTPNone.IARCNone.OSHANone.Assessment toxicity to reproductionFluopyram caused reproduction toxicity in a two-generation study in rats only at dose levels also toxic to the parent animals. The reproduction toxicity seen with Fluopyram is related to parental toxicity. Trifloxystrobin caused reduced body weight development in offspring during lactation only at doses also producing systemic toxicity in adult rats.Assessment developmental toxicityFluopyram caused developmental toxicity only at dose levels toxic to the dams. The developmental effects seen with Fluopyram are related to maternal toxicity.Trifloxystrobin caused developmental toxicity only at dose levels toxic to the dams. The developmental effects seen with Trifloxystrobin are related to maternal toxicity.Aspiration hazardBased on available data, the classification criteria are not met.LUNA SENSATION®8/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 Further informationOnly acute toxicity studies have been performed on the formulated product.The non-acute information pertains to the active ingredient(s).SECTION 12: ECOLOGICAL INFORMATIONToxicity to fish LC50 (Oncorhynchus mykiss (rainbow trout)) 0.091 mg/lExposure time: 96 hToxicity to aquatic invertebratesEC50 (Daphnia magna (Water flea)) 0.086 mg/lExposure time: 48 hLC50 (Mysidopsis bahia (mysid shrimp)) 0.00862 mg/l Exposure time: 96 hThe value mentioned relates to the active ingredient trifloxystrobin.Toxicity to aquatic plants IC50 (Raphidocelis subcapitata (freshwater green alga)) 0.292 mg/lGrowth rate; Exposure time: 72 hEC10 (Desmodesmus subspicatus (green algae)) 0.0025 mg/lGrowth rate; Exposure time: 72 hThe value mentioned relates to the active ingredient trifloxystrobin. Biodegradability Fluopyram:Not rapidly biodegradableTrifloxystrobin:Not rapidly biodegradableKoc Fluopyram: Koc: 279Trifloxystrobin: Koc: 2377Bioaccumulation Fluopyram: Bioconcentration factor (BCF) 18Does not bioaccumulate.Trifloxystrobin: Bioconcentration factor (BCF) 431Does not bioaccumulate.Mobility in soil Fluopyram: Moderately mobile in soilsTrifloxystrobin: Slightly mobile in soilsAdditional ecologicalinformationNo other effects to be mentioned.Environmental precautions Do not apply directly to water, to areas where surface water is presentor to intertidal areas below the mean high water mark.Drift and runoff from treated areas may be hazardous to aquaticorganisms in adjacent sites.Do not apply when weather conditions favor runoff or drift.Do not allow product to enter streams, sewers or other waterways.Do not contaminate surface or ground water by cleaning equipment ordisposal of wastes, including equipment wash water.Apply this product as specified on the label.LUNA SENSATION®9/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 SECTION 13: DISPOSAL CONSIDERATIONSWaste treatment methodsProduct Dispose in accordance with all local, state/provincial and federalregulations.Pesticide, spray mixture or rinse water that cannot be used according tolabel instructions may be disposed of on site or at an approved wastedisposal facility.Follow advice on product label and/or leaflet.Contaminated packaging Do not re-use empty containers.Triple rinse containers.Completely empty container into application equipment, then dispose ofempty container in a sanitary landfill, by incineration or by otherprocedures approved by state/provincial and local authorities.If burned, stay out of smoke.Follow advice on product label and/or leaflet.RCRA Information Characterization and proper disposal of this material as a special orhazardous waste is dependent upon Federal, State and local laws andare the user's responsibility. RCRA classification may apply.SECTION 14: TRANSPORT INFORMATION49CFR Not dangerous goods / not hazardous materialIMDGUN number 3082Class 9Packaging group IIIMarine pollutant YESProper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,N.O.S.(TRIFLOXYSTROBIN SOLUTION)IATAUN number 3082Class 9Packaging group IIIEnvironm. Hazardous Mark YESProper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,N.O.S.(TRIFLOXYSTROBIN SOLUTION )This transportation information is not intended to convey all specific regulatory information relating to this product. It does not address regulatory variations due to package size or special transportation requirements.LUNA SENSATION®10/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 Freight Classification: INSECTICIDES OR FUNGICIDES, N.O.I., OTHER THANPOISONSECTION 15: REGULATORY INFORMATIONEPA Registration No.264-1090US Federal RegulationsTSCA listWater 7732-18-51,2-Propanediol 57-55-6Polyethylene-polypropylene copolymer 9003-11-6US. Toxic Substances Control Act (TSCA) Section 12(b) Export Notification (40 CFR 707, Subpt D) No export notification needs to be made.SARA Title III - Section 302 - Notification and InformationNot applicable.SARA Title III - Section 313 - Toxic Chemical Release ReportingNone.US States Regulatory ReportingCA Prop65This product does not contain any substances known to the State of California to cause cancer.This product does not contain any substances known to the State of California to causereproductive harm.US State Right-To-Know Ingredients1,2-Propanediol 57-55-6 MN, RINone.EPA/FIFRA Information:This chemical is a pesticide product registered by the Environmental Protection Agency and is subject to certain labeling requirements under federal pesticide law. These requirements differ from the classification criteria and hazard information required for safety data sheets, and for workplace labels of non-pesticide chemicals. Following is the hazard information required on the pesticide label:Signal word:Caution!Hazard statements:Harmful if swallowed, inhaled or absorbed through the skin.Avoid contact with skin, eyes and clothing.Avoid inhalation of vapour or mist.SAFETY DATA SHEETLUNA SENSATION®11/11 Version 4.0/USA Revision Date: 06/30/2020 102000012886Print Date: 06/30/2020 SECTION 16: OTHER INFORMATIONAbbreviations and acronyms49CFR Code of Federal Regulations, Title 49ACGIH US. ACGIH Threshold Limit ValuesATE Acute toxicity estimateCAS-Nr. Chemical Abstracts Service numberCERCLA Comprehensive Environmental Response, Compensation, and Liability Act EINECS European inventory of existing commercial substancesELINCS European list of notified chemical substancesIARC International Agency for Research on CancerIATA International Air Transport AssociationIMDG International Maritime Dangerous GoodsN.O.S. Not otherwise specifiedNTP US. National Toxicology Program (NTP) Report on CarcinogensOECD Organization for Economic Co-operation and DevelopmentTDG Transportation of Dangerous GoodsTWA Time weighted averageUN United NationsWHO World health organisationNFPA 704 (National Fire Protection Association):Health - 2 Flammability - 1 Instability - 0 Others - noneHMIS (Hazardous Materials Identification System, based on the Third Edition Ratings Guide) Health - 2 Flammability - 1 Physical Hazard - 0 PPE -0 = minimal hazard, 1 = slight hazard, 2 = moderate hazard, 3 = severe hazard, 4 = extreme hazard Reason for Revision: The following sections have been revised: Section 2: Hazards Identification. Section 3: Composition / Information on Ingredients. Section 11: Toxicological Information. Section 12. Ecological information. Reviewed and updated for general editorial purposes.Revision Date: 06/30/2020This information is provided in good faith but without express or implied warranty. The customer assumes all responsibility for safety and use not in accordance with label instructions. The product names are registered trademarks of Bayer.。
CHEMLOK 8110 商品安全数据表说明书
USA SAFETY DATA SHEET3000000013401. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONProduct name: CHEMLOK 8110 Product Use/Class:Aqueous AdhesiveLORD Corporation 111 LORD DriveCary, NC 27511-7923 USATelephone: 814 868-3180Non-Transportation Emergency: 814 763-2345 Chemtrec 24 Hr Transportation Emergency No.800 424-9300 (Outside Continental U.S. 703 527-3887)EFFECTIVE DATE: 08/21/20192. HAZARDS IDENTIFICATIONGHS CLASSIFICATION:Skin sensitization Category 1Reproductive toxicity Category 1BSpecific target organ systemic toxicity (single exposure) Category 1 Respiratory system, Systemic toxicity Specific target organ systemic toxicity (repeated exposure) Category 1 Aspiration hazard Category 1Hazardous to the aquatic environment - acute hazard Category 2 Hazardous to the aquatic environment - chronic hazard Category 2GHS LABEL ELEMENTS: Symbol(s)Signal WordD ANGERHazard StatementsMay cause an allergic skin reaction.May damage fertility or the unborn child.Causes damage to organs.(Respiratory system, Systemic toxicity) Causes damage to organs through prolonged or repeated exposure. May be fatal if swallowed and enters airways. Toxic to aquatic life.Toxic to aquatic life with long lasting effects.Precautionary Statements PreventionObtain special instructions before use.Do not handle until all safety precautions have been read and understood. Wear protective gloves.Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment.ResponseGet medical advice/attention if you feel unwell.IF exposed: Call a POISON CENTER or doctor/physician.Specific treatment (see supplemental first aid instructions on this label).IF ON SKIN: Wash with plenty of soap and water.If skin irritation or rash occurs: Get medical advice/attention.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.Do NOT induce vomiting.Wash contaminated clothing before reuse.Collect spillage.StorageStore locked up.Disposal:Dispose of contents/container in accordance with waste/disposal laws and regulations of your country or particular locality.Other Hazards:This product contains component(s) which have the following warnings; however based on the GHS classification criteria of your country or locale, the product mixture may be outside the respective category(s).Acute: Vapor harmful; may affect the brain or nervous system causing dizziness, headache or nausea. May cause central nervous system depression characterized by the following progressive steps: headache, dizziness, staggering gait, confusion, unconsciousness or coma. Possible irritation of the respiratory system can occur causing a variety of symptoms such as dryness of the throat, tightness of the chest, and shortness of breath. May cause skin and eyeirritation. May be harmful if swallowed. Ingestion is not an expected route of entry in industrial or commercial uses.Chronic: Prolonged or repeated contact may result in dermatitis. Repeated or prolonged solvent overexposure may result in permanent central nervous system damage. Formaldehyde may be released from this product in processes that involve heat. Formaldehyde is a skin and respiratory sensitizer, eye and throat irritant, and acute toxicant.Formaldehyde has been identified by NTP and IARC as a known human carcinogen (IARC 1), and by OSHA as a potential human carcinogen. Workplace exposure to formaldehyde is regulated by OSHA Standard 29 CFR1910.1048. IARC has designated carbon black as Group 2B - inadequate evidence for carcinogenicity in humans, but sufficient evidence in experimental animals. In 2006 IARC reaffirmed its 1995 finding that there is "inadequateevidence" from human health studies to assess whether carbon black causes cancer in humans. Further,epidemiological evidence from well-conducted investigations has shown no causative link between carbon black exposure and the risk of malignant or non-malignant respiratory disease in humans. IARC has designated titanium dioxide (TiO2) as Group 2B – possibly carcinogenic to humans in dust form. However, a number of long termanimal studies and human epidemiology studies evaluating TiO2 and workplace exposure show insufficient evidence for carcinogenic effects. EPA, NTP and OSHA do not designate TiO2 as a carcinogen and ACGIH designates TiO2 as A4 - not classifiable as a human carcinogen. Mortaility from other chronic diseases, including other respiratory diseases, was not associated with exposure to TiO2 dust. TiO2 is not present in this product as a dust and no airborne exposure is expected during application.3. COMPOSITION/INFORMATION ON INGREDIENTSChemical Name CAS Number RangeZinc compound PROPRIETARY 5 - 10%Carbon black1333-86-4 1 - 5%Propylene glycol monomethylether107-98-2 1 - 5%Nonylphenol ethoxylate compound PROPRIETARY0.1 - 0.9%Titanium dioxide13463-67-70.1 - 0.9%Resorcinol108-46-30.1 - 0.9%Any "PROPRIETARY" component(s) in the above table is considered trade secret, thus the specific chemical and its exact concentration is being withheld.The above Nonylphenol ethoxylate compound is listed by ECHA as an SVHC.4. FIRST AID MEASURESFIRST AID - EYE CONTACT: Flush eyes immediately with large amount of water for at least 15 minutes holding eyelids open while flushing. Get prompt medical attention.FIRST AID - SKIN CONTACT: Flush contaminated skin with large amounts of water while removing contaminated clothing. Wash affected skin areas with soap and water. Get medical attention if symptoms occur.FIRST AID - INHALATION: Move person to fresh air. Restore and support continued breathing. If breathing is difficult, give oxygen. Get immediate medical attention.FIRST AID - INGESTION: If swallowed, do not induce vomiting. Call a physician or poison control center immediately for further instructions. Never give anything by mouth if victim is rapidly losing consciousness, unconscious or convulsing.5. FIRE-FIGHTING MEASURESSUITABLE EXTINGUISHING MEDIA: Carbon Dioxide, Dry Chemical, Foam, Water FogUNSUITABLE EXTINGUISHING MEDIA: Not determined for this product.SPECIFIC HAZARDS POSSIBLY ARISING FROM THE CHEMICAL: Keep containers tightly closed. Closed containers may rupture when exposed to extreme heat. Use water spray to keep fire exposed containers cool. During a fire, irritating and/or toxic gases and particulate may be generated by thermal decomposition or combustion.SPECIAL PROTECTIVE EQUIPMENT AND PRECAUTIONS FOR FIRE-FIGHTERS: Wear full firefighting protective clothing, including self-contained breathing apparatus (SCBA). If water is used, fog nozzles are preferable.6. ACCIDENTAL RELEASE MEASURESPERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES: Avoid contact. Avoid breathing vapors. Use appropriate respiratory protection for large spills or spills in confined area.ENVIRONMENTAL PRECAUTIONS: Do not contaminate bodies of water, waterways, or ditches, with chemical or used container.METHODS AND MATERIALS FOR CONTAINMENT AND CLEANUP: Keep non-essential personnel a safe distance away from the spill area. Notify appropriate authorities if necessary. Avoid contact. Before attempting cleanup, refer to hazard caution information in other sections of the SDS form. Contain and remove with inert absorbent material.7. HANDLING AND STORAGEHANDLING: Keep closure tight and container upright to prevent leakage. Avoid skin and eye contact. Wash thoroughly after handling. Do not handle until all safety precautions have been read and understood. Empty containers should not be re-used. Use with adequate ventilation.STORAGE: Store only in well-ventilated areas. Keep from freezing. Keep container closed when not in use.INCOMPATIBILITY: Strong acids, bases, and strong oxidizers.8. EXPOSURE CONTROLS/PERSONAL PROTECTIONCOMPONENT EXPOSURE LIMITChemical Name ACGIH TLV-TWA ACGIH TLV-STELOSHA PEL-TWAOSHA PEL-CEILINGSkinZinc compound 2 mg/m310 mg/m3 5 mg/m3 N.E.N.A.Carbon black 3 mg/m3N.E. 3.5 mg/m3 N.E.N.A. Propylene glycolmonomethylether100 ppm150 ppm N.E. N.E.N.A.Nonylphenol ethoxylatecompoundN.E.N.E.N.E. N.E.N.A.Titanium dioxide10 mg/m3N.E.15 mg/m3 N.E.N.A.Resorcinol10 ppm20 ppm N.E. N.E.N.A.N.A. - Not Applicable, N.E. - Not Established, S - Skin DesignationEngineering controls: Sufficient ventilation in pattern and volume should be provided in order to maintain air contaminant levels below recommended exposure limits.PERSONAL PROTECTION MEASURES/EQUIPMENT:RESPIRATORY PROTECTION: Use a NIOSH approved chemical/mechanical filter respirator designed toremove a combination of particulates and organic vapor if occupational limits are exceeded. For emergencysituations, confined space use, or other conditions where exposure limits may be greatly exceeded, use an approved air-supplied respirator. For respirator use observe OSHA regulations (29CFR 1910.134) or use in accordance with applicable laws and regulations of your country or particular locality. Note: If the exposure limit for formaldehyde is exceeded, a formaldehyde-specific, formaldehyde/organic vapor combination, or airline respirator may be required.SKIN PROTECTION: Use neoprene, nitrile, or rubber gloves to prevent skin contact.EYE PROTECTION: Use safety eyewear including safety glasses with side shields and chemical goggles where splashing may occur.OTHER PROTECTIVE EQUIPMENT: Remove and wash contaminated clothing before reuse.HYGIENIC PRACTICES: Wash hands before eating, smoking, or using toilet facility. Do not smoke in anychemical handling or storage area. Food or beverages should not be consumed anywhere this product is handled or stored. Wash thoroughly after handling.9. PHYSICAL AND CHEMICAL PROPERTIESTypical values, not to be used for specification purposes.ODOR: Mild VAPOR PRESSURE: N.D.APPEARANCE: Gray VAPOR DENSITY: Heavier than Air PHYSICAL STATE: Liquid LOWER EXPLOSIVE LIMIT: 1.6 %(V)FLASH POINT:≥ 201 °F, 93 °CUPPER EXPLOSIVE LIMIT: 13.8 %(V)Setaflash Closed CupBOILING RANGE: 100 - 120 °C EVAPORATION RATE: Slower than n-butyl-acetate AUTOIGNITION TEMPERATURE:N.D.DENSITY: 1.16 g/cm3 - 9.67 lb/gal DECOMPOSITION TEMPERATURE:N.D. VISCOSITY, DYNAMIC: ≥20 mPa.s @ 25 °C ODOR THRESHOLD: N.D.VISCOSITY, KINEMATIC: ≥17 mm2/s @ 25 °CSOLUBILITY IN H2O: Water Dispersible VOLATILE BY WEIGHT: 64.55 %pH: 6.5VOLATILE BY VOLUME: 75.28 %FREEZE POINT: 32 F VOC CALCULATED: 1.23 lb/gal, 148 g/l COEFFICIENT OF WATER/OILN.D. METHOD 24: 1.70 lb/gallonDISTRIBUTION:LEGEND: N.A. - Not Applicable, N.E. - Not Established, N.D. - Not Determined10. STABILITY AND REACTIVITYHAZARDOUS POLYMERIZATION: Hazardous polymerization will not occur under normal conditions. STABILITY: Product is stable under normal storage conditions.CONDITIONS TO AVOID: High temperatures. Sources of ignition.INCOMPATIBILITY: Strong acids, bases, and strong oxidizers.HAZARDOUS DECOMPOSITION PRODUCTS: May contain CO, CO2, oxides of nitrogen, oxides of sulfur, halogenated by-products, Metal oxides11. TOXICOLOGICAL INFORMATIONEXPOSURE PATH: Refer to section 2 of this SDS.SYMPTOMS:Refer to section 2 of this SDS.TOXICITY MEASURES:Chemical Name LD50/LC50Zinc compound Oral LD50: Rat> 5,000 mg/kgGHS LC50 (vapour): Acute toxicity point estimate55 mg/l Carbon black Oral LD50: Rat> 15,400 mg/kgDermal LD50: Rabbit> 3 g/kgGHS LC50 (vapour): Acute toxicity point estimate55 mg/l Propylene glycol monomethylether Oral LD50: Rat5,000 mg/kgDermal LD50: Rabbit13 g/kgGHS LC50 (vapour): Acute toxicity point estimate11 mg/l GHS LC50(dust and mist): Acute toxicity point estimate1.5 mg/l Inhalation LC50:Rat>7559 ppm/6 hNonylphenol ethoxylate compound N.D.Titanium dioxide Oral LD50: Rat> 10,000 mg/kgDermal LD50: rabbit> 5,000 mg/kgGHS LC50 (vapour): Acute toxicity point estimate55 mg/l Resorcinol Oral LD50: Rat202 mg/kgDermal LD50: Rabbit3,360 mg/kgInhalation LC50: Rat21.3 mg/l/1 hGerm cell mutagenicity: No classification proposedCarcinogenicity: No classification proposedReproductive toxicity: Category 1B - May damage fertility or the unborn child.Components contributing to classification: Methanol.12. ECOLOGICAL INFORMATIONECOTOXICITY:Chemical Name EcotoxicityZinc compound N.D.Carbon black N.D.Propylene glycol monomethylether Fish: Pimephales promelas20.8 g/l96 h StaticInvertebrates: Daphnia magna23,300 mg/l48 hNonylphenol ethoxylate compound N.D.Titanium dioxide N.D.Resorcinol Fish: Pimephales promelas36 - 100 mg/l96 h StaticPimephales promelas100 mg/l96 h flow-throughOncorhynchus mykiss> 100 mg/l96 h flow-throughPimephales promelas53.4 mg/l96 hInvertebrates: Daphnia magna78 mg/l48 hPERSISTENCE AND DEGRADABILITY:Not determined for this product. BIOACCUMULATIVE: Not determined for this product.MOBILITY IN SOIL: Not determined for this product.OTHER ADVERSE EFFECTS: Not determined for this product.13. DISPOSAL CONSIDERATIONSDISPOSAL METHOD: Disposal should be done in accordance with Federal (40CFR Part 261), state and local environmental control regulations. If waste is determined to be hazardous, use licensed hazardous waste transporter and disposal facility.14. TRANSPORT INFORMATIONUS DOT RoadProper Shipping Name: Environmentally hazardous substances, liquid, n.o.s.Hazard Class: 9SECONDARY HAZARD: NoneUN/NA Number: 3082Packing Group: IIIEmergency Response Guide Number: 171For US DOT non-bulk road shipments this material may be classified as NOT REGULATED. For the mostaccurate shipping information, refer to your transportation/compliance department regarding changes inpackage size, mode of shipment or other regulatory descriptors.IATA CargoPROPER SHIPPING NAME: Environmentally hazardous substance, liquid, n.o.s.Hazard Class: 9HAZARD CLASS: NoneUN NUMBER: 3082PACKING GROUP: IIIEMS: 9LIMDGPROPER SHIPPING NAME: Environmentally hazardous substance, liquid, n.o.s.Hazard Class: 9HAZARD CLASS: NoneUN NUMBER: 3082PACKING GROUP: IIIEMS: F-AThe listed transportation classification applies to non-bulk shipments. It does not address regulatory variations due to changes in package size, mode of shipment or other regulatory descriptors. For the most accurate shipping information, refer to your transportation/compliance department.15. REGULATORY INFORMATIONU.S. FEDERAL REGULATIONS: AS FOLLOWS:SARA SECTION 313This product contains the following substances subject to the reporting requirements of Section 313 of Title III of the Superfund Amendment and Reauthorization Act of 1986 and 40 CFR part 372.:Chemical Name CAS Number Weight % Less ThanZinc compound PROPRIETARY10.0%TOXIC SUBSTANCES CONTROL ACT:INVENTORY STATUSThe chemical substances in this product are on the TSCA Section 8 Inventory.EXPORT NOTIFICATIONThis product contains the following chemical substances subject to the reporting requirements of TSCA 12(B) if exported from the United States:None16. OTHER INFORMATIONUnder HazCom 2012 it is optional to continue using the HMIS rating system. It is important to ensure employees have been trained to recognize the different numeric ratings associated with the HazCom 2012 and HMIS schemes.HMIS RATINGS - HEALTH: 2* FLAMMABILITY: 1 PHYSICAL HAZARD: 0* - Indicates a chronic hazard; see Section 2Revision: Section 2, Section 11Effective Date: 08/21/2019DISCLAIMERThe information contained herein is, to the best of our knowledge and belief, accurate. However, since the conditions of handling and use are beyond our control, we make no guarantee of results, and assume no liability for damages incurred by use of this material. It is the responsibility of the user to comply with all applicable federal, state and local laws and regulations.。
美蓓亚三美株式会社
美蓓亚三美集团绿色采购管理要领EM10507 附属文件环境化学物质清单Ver.2.00Ⅰ 禁用物质Ⅱ 预计禁用物质Ⅲ 顾客要求禁用物质Ⅳ 管理物质发行：2018年02月01日实行：2018年04月02日美蓓亚三美株式会社Ⅰ禁用物质国内外法律规定、国际条约等禁止或限制使用的化学物质中，本公司产品中可能含有的化学物质。
* 如未指定限制值单位，则单位为ppm。
所有限制要求均为低于限制数值。
No. 化学物质（群）名 限制对象（分类）美蓓亚三美集团限制值（单位：ppm）备注主要参照的法律规定1 镉及其化合物・树脂、树脂产品、树脂材料（包括橡胶、胶膜等）・涂料、油墨、颜料、染料、润滑油脂、油脂、胶合剂（无挥发成分状态）5 RoHS指令（2011/65/EU）EU REACH规则AnnexⅩⅦ<适用豁免>RoHS适用豁免品 ・无铅焊料（焊锡棒、焊线、松香芯焊锡、焊锡膏、焊锡球）・印刷线路板焊接部・部件的焊锡电镀部位（如引线端子等）・部件的镀锡部位（热浸镀除外）20・黄铜、锌及锌合金・铝及铝合金・部件的镀锡以外的金属电镀部位・无电解镀镍部位・厚膜浆料材料、电阻75其他 752 铅及其化合物・树脂、树脂产品、树脂材料（包括橡胶、胶膜等）・涂料、油墨、颜料、染料、润滑油脂、油脂、胶合剂（无挥发成分状态）100 RoHS指令（2011/65/EU）<适用豁免>RoHS适用豁免品 ・无铅焊料（焊锡棒、焊线、松香芯焊锡、焊锡膏、焊锡球）500・印刷线路板焊接部・部件的焊接电镀部分（包括引线端等熔焊电镀在内）・部件的镀锡部分・部件镀锡之外的金属电镀部分・化学镀镍部分1,000其他 1,0003 六价铬化合物所有用途 1,000 RoHS指令（2011/65/EU）<适用豁免>RoHS适用豁免品4 汞极其化合物所有用途 禁止有意添加且限制值为1,000RoHS指令（2011/65/EU）<适用豁免>RoHS适用豁免品5 PBB；聚溴联苯 所有用途 1,000 RoHS指令（2011/65/EU） 6 PBDE；聚溴联苯醚 所有用途 1,000 RoHS指令（2011/65/EU）7 PCB；多氯化联苯 所有用途 禁止有意添加且限制值为50 化审法EU POPs规则 AnnexⅠ8 PCN；聚氯化萘(氯数 1以上) 所有用途 禁止有意添加且限制值为50化审法EU POPs规则AnnexⅠ9 PCT；聚氯三联苯 所有用途 禁止有意添加且限制值为50 化审法EU REACH规则 AnnexⅩⅦ10 石棉类 所有用途 禁止有意添加 安卫法德国化学品禁止规则EU REACH规则AnnexⅩⅦ11 短链氯化石蜡(碳数10-13)(CAS No.85535-84-8） 所有用途 禁止有意添加且限制值为1,000化审法EU POPs规则AnnexⅠ12 臭氧层消耗物质*蒙特利尔协议附属文件A（类别Ⅰ、Ⅱ）附属文件B（类别Ⅰ、Ⅱ、Ⅲ）附属文件C（类别Ⅰ、Ⅱ、Ⅲ）附属文件E（类别Ⅰ） 所有用途 禁止有意添加 臭氧层保护法EU规则((EC) No1005/2009)13 氢氟烃（HFC)、全氟碳(PFC)、六氟化硫（SF6） 所有用途 禁止有意添加 EU规则((EU) No517/2014)14 双（三丁基锡）=氧化物；TBTO(CAS No. 56-35-9) 所有用途 禁止有意添加且锡元素1,000化审法EU REACH规则AnnexⅩⅦ15 三取代有机锡化合物（三丁基锡（TBT）化合物、三苯基锡（TPT）化合物等） 所有用途 禁止有意添加且锡元素1,000化审法EU REACH规则AnnexⅩⅦ16 二丁基锡(DBT)化合物 所有用途 锡元素1,000 EU REACH规则AnnexⅩⅦ17 二辛基锡(DOT)化合物 仅适用于以下物品・接触皮肤的纤维产品・玩具、儿童用品、育儿产品・双组分室温固化（RTV-2）成型试剂盒 锡元素1,000 EU REACH规则AnnexⅩⅦ18 特定胺化合物及生成特定胺类的部分偶氮染料及颜料（着色剂）（*1） 所有用途 30EU REACH规则AnnexⅩⅦ19 甲醛；福尔马林(CAS No. 50-00-0) 使用纤维板、刨花板以及复合板的木工产品（扬声器、架子等）0.1（测量值密闭小室法）德国化学品禁止规则20 镍及其化合物 长期接触皮肤的用途（耳机、耳麦等） 0.5μg/cm2/week试验标准EN1811：2011+A1：2015 EU指令（94/27/EC） EU REACH规则 AnnexⅩⅦ21 砷及其化合物（包括三氧化二砷、五氧化二砷） 仅适用于木材防腐剤、玻璃消泡剂、澄清剂等用途1,000 EU REACH规则AnnexⅩⅦPRTR法22 放射性物质所有用途 禁止有意添加 放射线障害防止法23 全氟辛烷磺酸（PFOS）及其盐 所有用途 禁止有意添加且限制值为1000 化审法EU POPs规则 AnnexⅠ24 特定苯并三唑2-(2H-1,2,3-苯并三唑-2-基)-4,6-二叔丁基苯酚（UV-320）(CAS No. 3846-71-7) 所有用途 禁止有意添加化审法25 氯化钴(CAS No. 7646-79-9) 所有用途 禁止有意添加且限制值为1,000化审法EU规则((EC) No1272/2008)26 氧化铍(CAS No. 1304-56-9) 所有用途 禁止有意添加且限制值为1,000劳动安全卫生法EU规则((EC) No1272/2008)27 富马酸二甲酯(DMF)(CAS No. 624-49-7) 所有用途 0.1 欧州委员会决议(2009/251/EC)EU REACH规则AnnexⅩⅦ28 磷酸三（2-氯乙基）酯（TCEP）(CAS No. 115-96-8) 所有用途 1,000 EU REACH规则AnnexⅩⅣ佛蒙特州 法律规定29 磷酸三（1-氯-2-丙基）酯（TCPP）(CAS No. 13674-84-5)用于树脂、纤维的阻燃剂用途 1,000 佛蒙特州 法律规定30 磷酸三（1,3-二氯-2-丙基）酯（TDCPP）(CAS No. 13674-87-8)用于树脂、纤维的阻燃剂用途 1,000 佛蒙特州 法律规定31 六溴环十二烷（HBCDD）以及所有主要非对映体 所有用途 禁止有意添加且限制值为100化审法EU REACH规则AnnexⅩⅣEU POPs规则Annex I32 二苯胺与苯乙烯和 2,4,4-三甲基戊烯的反应产物（BNST）(CAS No.68921-45-9) 除橡胶材料外的所有用途(但，轮胎橡胶材料属于限制对象)禁止有意添加 加拿大环境保护法33 全氟辛酸（PFOA）及其盐和酯（*2） 所有用途 1,000 关于使用挪威特定有害化学物质等的规则34 PAHs （下述8种物质） 长期或反复直接接触皮肤或口腔的橡胶或塑料部件玩具 各成分0.5 EU REACH规则AnnexⅩⅦ苯并[a]芘(CAS No. 50-32-8)苯并[e]芘(CAS No. 192-97-2)苯并[a]蒽(CAS No. 56-55-3)屈(CAS No. 218-01-9)苯并[b]荧蒽(CAS No. 205-99-2)玩具以外的成形品各成分1苯并[j]荧蒽(CAS No. 205-82-3)苯并[k]荧蒽(CAS No. 207-08-9)二苯并[a，h]蒽(CAS No. 53-70-3)35 卤代二苯甲烷（*3）所有用途 禁止有意添加 EU REACH规则AnnexⅩⅦ36 邻苯二甲酸二（2-乙基己基）酯（DEHP）(CAS No. 117-81-7) 玩具、儿童产品禁止有意添加且6种物质总量1,000台湾CNS4797（玩具安全标准）美国消费者产品安全法新法(CPSIA)日本玩具安全标准(ST标准)EU REACH规则AnnexⅩⅦ邻苯二甲酸二丁酯（DBP） (CAS No. 84-74-2)邻苯二甲酸丁苄酯（BBP） (CAS No. 85-68-7)邻苯二甲酸二异壬酯（DINP） (CAS No. 28553-12-0) (CAS No.68515-48-0)邻苯二甲酸二异癸酯（DIDP） (CAS No. 26761-40-0)邻苯二甲酸二正辛酯（DNOP）(CAS No. 117-84-0)37 苯(CAS No. 71-43-2) 玩具、儿童产品 5 EU REACH规则AnnexⅩⅦ物质或混合物 1,00038 三（1-氮丙啶基）氧化膦（TAPO）(CAS No. 545-55-1) 直接接触皮肤的纤维产品 禁止有意添加 EU REACH规则AnnexⅩⅦ39 三（2,3-二溴丙基）磷酸酯（TBPP）(CAS No. 126-72-7) 直接接触皮肤的纤维产品 禁止有意添加 EU REACH规则AnnexⅩⅦ40 高氯酸盐 所有用途产品的 0.006 加利福尼亚州高氯酸盐法规41 2,4,6-三-叔-丁基苯酚(CAS No. 732-26-3)所有用途 禁止有意添加 化审法42 汞、镉、六价铬、铅 捆包材料 总量:100 EU指令(94/62/EC) (*1) 特定胺化合物一览No. 化学物质名 CAS No.1 4-氨基偶氮苯 60-09-32 邻氨基苯甲醚 90-04-03 2-萘胺 91-59-84 3,3'-二氯联苯胺 91-94-15 4-氨基二苯基 92-67-16 联苯胺 92-87-57 邻甲苯胺 95-53-48 4-氯 - 邻 - 甲苯胺 95-69-29 2,4-甲苯二胺 95-80-710 邻氨基偶氮甲苯 97-56-311 5-硝基邻甲苯胺 99-55-812 4,4'-亚甲基双（2-氯苯胺） 101-14-413 4,4'-二氨基二苯基甲烷 101-77-914 4,4'-氧基二苯胺及其盐 101-80-415 P-氯苯胺 106-47-816 3,3'-二甲氧基联苯胺 119-90-417 3,3'-二甲基联苯胺 119-93-718 邻氨基对甲苯甲醚 120-71-819 2,4,5-三甲基苯胺 137-17-720 4,4'-硫代二苯胺 139-65-121 2,4-二氨基茴香醚 615-05-422 3,3'-二甲基-4,4'-二氨基二苯基甲烷 838-88-0(*2)全氟辛酸（PFOA）及其盐和酯No. 化学物质名 CAS No.1 全氟辛酸（PFOA） 335-67-12 全氟辛酸铵（APFO） 3825-26-13 全氟辛酸钠盐 335-95-54 全氟辛酸钾盐 2395-00-85 全氟辛酸银盐 335-93-36 全氟辛酸氟化物 335-66-07 全氟辛酸甲酯 376-27-28 全氟辛酸乙酯 3108-24-5(*3) 卤代二苯甲烷No. 化学物质（群）名 CAS No.1 四氯二苯甲烷单甲基酯 76253-60-62 单二氯二苯基甲烷 81161-70-83 单甲基二溴二苯基甲烷 99688-47-8II 预计禁用物质相关法律法规等规定了使用期限的物质。
（ECL）NA931-GEHealthcareLifeSciences
Product Specification SheetCode: NA931WarningFor research use only.Not recommended or intended for diagnosis of disease in humans or animals.Do not use internally or externally in humans or animals. Before using this product, please read the instructions for safe handling, storage and disposalStorageStore at 2–8°C. Do not freeze. Under these conditions, the product is stable for at least 6 months from the date of despatch.ExpirySee outer packaging.Safety warnings and precautionsAll chemicals should be considered as potentially hazardous. We therefore recommend that this product is handled only by those persons who have been trained in laboratory techniques and that it is used in accordance with the principles of good laboratory practice. Wear suitable protective clothing such as laboratory overalls, safety glasses and gloves. Care should be taken to avoid contact with skin or eyes. In the case of contact with skin or eyes wash immediately with water. See material safety data sheet(s) and/or safety statement(s) for specific advice. ComponentsHorseradish Peroxidase conjugated antibody is supplied in Phosphate Buffered Saline (Sodium Phosphate 0.1 M, NaCl 0.1 M) pH 7.5, containing 1% (w/v) Bovine Serum Albumin and an anti-microbial agent.DescriptionPurification to ensure species-specificityThe antibody is prepared by hyper-immunizing sheep with purified immunoglobulin fractions from normal mouse serum to produce high affinity antibodies. The pooled antiserum is used to produce an immunoglobulin preparation which is then affinity adsorbed to remove cross-reacting antibodies towards rat, human and rabbit immunoglobulins. These activities are thoroughly depleted to ensure species-specificity.Finally, to select for specific binding to mouse IgG, the antibodies are purified using an affinity column of mouse IgG. After washingto remove non-specific serum components and low affinity antibodies, the species-specific antibodies are eluted using carefully selected, mild conditions which minimize aggregation and preserve immunological activity, yet which will elute high affinity antibodies.Preparation of labelled antibodyThe enzyme Horseradish Peroxidase is attached to the immunoglobulin molecules using an adaptation of the periodate oxidation technique (1). This method has been found not to affect the effective binding of the antibody to the antigen or the activity of the enzyme.Quality controlFor every batch of enzyme-linked antibody that is produced the antibody titre is determined in an ELISA. The substrate used forthe peroxidase is 2,2’-Azinobis[3-Ethylbenzothiazoline Sulphonate, diammonium salt], ABTS™.Every batch is also QC tested in a Western blotting system. Thisis performed using Amersham Protran™ Premium membrane containing serially-diluted tubulin protein and is immunodetected with: primary monoclonal anti-tubulin antibody and anti-mouse IgG HRP secondary antibody (NA931). Blots are detected using Amersham ECL and Amersham ECL Prime™ detection systems. Applications1. Protein blottinga) Detection with Amersham ECL Western blotting reagents (2) This reagent has been shown to be suitable for use in ECL Western blotting applications.The control system used was the detection of monoclonal anti-tubulin.We have found in our laboratories that dilutions of: 1:2000 for monoclonal anti-tubulin; and 1:5000 for anti-mouse IgG, HRP are suitable for the detection of 3 ng of tubulin on Amersham Protran Premium membrane, exposed to Hyperfilm™ ECL for 5 minutes.To achieve the same sensitivity level on Amersham Hybond™, concentrations would typically be: anti-tubulin - 1:2000; andNA931 - 1:10000.b) Detection with Amersham ECL Prime Western blotting reagents (3, 4)Amersham ECL Prime Western blotting reagent is highly sensitive, giving an increase, for this antibody, of 4-20 fold over ECL detection. This property can be utilized in 2 ways:• Preservation of antibodies that are rare or costly• Increase in detectable sensitivity levelsThe control system used was the same as for Amersham ECL.The suitable antibody dilutions, to detect 3 ng of tubulin on Amersham Protran Premium membrane are: anti-tubulin - 1:5000; and NA931 - 1:50 000.For Amersham Hybond membrane antibody dilutions are typically: anti-tubulin - 1:10 000; and NA931-1:100 000.c) Colorimetric detectionA dilution of 1:300 is recommended.2. ELISAIf this reagent is to be used to detect mouse immunoglobulins, we have found in our laboratories that a dilution of 1:6000 is suitable for the detection of 1 µg of IgG.For greater sensitivity (for example down to 300 pg) the reagent should be diluted rather less (for example 1:500). A suitable diluent is Phosphate-Buffered Saline containing 0.05% (v/v) Tween™ 20.Amersham™ECL™ Anti-Mouse IgG, Horseradish Peroxidase-Linked Species-Specific Whole Antibody (from sheep)imagination at work3. ImmunocytochemistryWhen using the reagent as a second antibody inimmunocytochemistry on sections of formalin-fixed wax-embedded tissue the antibody can typically be diluted 1:100 in Phosphate-Buffered Saline. The user may wish to adjust this to obtain the required sensitivity for the tissue under investigation. If frozensections are used, acceptable staining may be obtained using even higher dilutions of the reagent.Protocol recommendations MembranesNitrocellulose and PVDF membranes are suitable for use with both detection systems. PVDF membrane is highly recommended for use with Amersham ECL Prime detection reagents.For high quality results the following guidelines should be followed: Blocking: Use enough blocking agent to block all non-specific sites. A typical block 5% non-fat dried milk in PBS Tween or TBS Tween (order RPN2125).Washing: The volume of wash buffer (eg PBS-T or TBS-T) must be sufficient to cover the membrane completely.Optimization of primary and secondary antibodies ECL detectionAmersham ECL Western blotting is a very sensitive technique. As such it is essential to optimize the system under study for high signal and low background for both primary and secondary antibodies.Dot blots are a quick and effective method of determining the optimum dilutions required for primary and secondary antibodies. Optimization details are set out in the RPN2106/2108/2109/2209/ 2134 booklets.Amersham ECL Prime detectionDue to the improved sensitivity of Amersham ECL Prime compared to ECL, optimization details as set out in the RPN2132/2133 booklets.Typical anti-mouse secondary antibody dilution ranges:Amersham ECL for nitrocellulose membrane 1:1000 to 1:5000 Amersham ECL Prime for nitrocellulose membrane 1:2000 to 1:10 000For PVDF membrane the use of higher dilutions may be necessary. The exact concentration of the secondary antibody will always be dependent upon the primary antibody used and the sensitivity and exposure times required.Detection: Ensure any excess Amersham ECL or Amersham ECL Prime detection reagents are sufficiently drained prior to exposure.Exposure times:Amersham ECL - exposure times of 1 to 15 minutes are suggested. Amersham ECL Prime - initial exposure times of 1 to 5 minutes are suggested.Signal can still be obtained up to 24 hours after the application of Amersham ECL Prime reagents, and for this exposure times of 1 to 2 hours may be required.Related productsAmersham ECL Western blottingdetection reagentsRPN2106/2108/2109/ 2209/2134Amersham ECL Prime Western blotting detection systemRPN2232 & RPN2236Amersham Protran Premium 10600048 RPN2020D Amersham Hybond membrane 10600058 RPN2020FAmersham Hyperfilm ECL film28906835/28906836/ 28906837/28906838/ 28906839Amersham ECL protein molecular weight markersRPN2107/2124/2125References1) NAKANE, P.K. and KAWAOI, A., Journal of Histochemistry andCytochemistry , 22, pp.1084-1091, 1974.2) WHITEHEAD, T.P. et al., Clin. Chem., 25, pp.1532-1546, 1979.3) AKHAVEN-TAFTI, H. et al., Clin. Chem., 41, pp.1368-1369, 1995.4) AKHAVEN-TAFTI, H. et al., Biolum. And Chemilum. Fundamentals and Applied Aspects, pp.199-202, Chichester, 1994.LegalGE, imagination at work and GE Monogram are trademarks of General Electric Company.Amersham, Hybond, ECL, ECL Prime and Hyperfilm are trademarks of GE Healthcare companies.ABTS is a trademark of Boehringer Mannheim GmBH Tween is a trademark of ICI Americas Inc.Amersham ECL Prime and Amersham ECL Select is manufactured and sold under license from Cyanagen Srl and is subject of US patent application number 2008241868 and 2008176251, and Italian application number TO2010A000580, together with other equivalent granted patents and patent applications in other countries.© 2006 - 2014 General Electric Company – All rights reserved First published 2006All goods and services are sold subject to the terms and conditions of sale of the company within GE Healthcare which supplies them. A copy of these terms and conditions is available on request. Contact your local GE Healthcare representative for the most current information.For your local office contact information, visit /contact GE Healthcare UK Limited Amersham PlaceLittle Chalfont, Buckinghamshire, HP7 9NA, UKGE Healthcare offices:GE Healthcare Bio-Sciences AB Björkgatan 30, 751 84 Uppsala, SwedenGE Healthcare Europe GmbHMunzinger Strasse 5, D-79111 Freiburg, GermanyGE Healthcare Bio-Sciences Corp.800 Centennial Avenue, P.O. Box 1327, Piscataway, NJ 08855-1327, USAGE Healthcare Japan Corporation Sanken Bldg. 3-25-1, Hyakunincho, Shinjuku-ku, Tokyo 169-0073, Japan29093068 Rev AA 01-2014。
CFDA SE (细胞增殖示踪荧光探针) 说明书
CFDA SE (细胞增殖示踪荧光探针) 产品编号产品名称包装C1031 CFDA SE (细胞增殖示踪荧光探针) 5mg产品简介：CFDA SE 的全称为Carboxyfluorescein diacetate, succinimidyl ester ，是一种近年来被广泛应用的细胞增殖检测用荧光探针，也可以用于细胞的荧光示踪。
基于CFDA SE 荧光标记的细胞增殖检测和[3H]-thymidine 掺入、BrdU 标记获得的检测结果完全一致，但同时可以提供更多的细胞增殖信息。
使用CFDA SE 检测可以提供整个细胞群中有多少比例的细胞分裂了1次、2次或更多次数，同时如果和其它荧光探针联用，可以获取不同分裂次数细胞的其它相关信息。
CFDA-SE 的分子式为C 29H 19NO 11，分子量为557.47，CAS number 为150347-59-4。
CFDA SE 可以通透细胞膜，进入细胞后可以被细胞内的酯酶(esterase)催化分解成CFSE ，CFSE 可以偶发性地(spontaneously)并不可逆地和细胞内蛋白的Lysine 残基或其它氨基发生结合反应，并标记这些蛋白。
在加入荧光探针CFDA SE 后大约24小时，即可充分标记细胞。
被CFDA SE 标记的非分裂细胞的荧光非常稳定，稳定标记的时间可达数个月。
CFDA SE 标记细胞的荧光非常均一，比以前使用的其它细胞示踪荧光探针例如PKH26的荧光更加均一，并且分裂后的子代细胞的荧光分配也更均匀。
由于CFDA SE 标记细胞的荧光非常均匀和稳定，每分裂一次子代细胞的荧光会减弱一半，这样通过流式细胞仪检测就可以检测出没有分裂的细胞，分裂一次的细胞(1/2的荧光强度)，分离两次的细胞(1/4的荧光强度)，分裂三次的细胞(1/8的荧光强度)以及类似的其它分裂次数的细胞。
采用CFDA SE 通过流式细胞仪检测获得的检测结果参考右图。
每一个峰代表一种分裂次数的细胞，从右至左的峰通常依次为分裂0次、1次、2次、3次等次数的细胞。
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Product Name: CAS No.: Cat. No.: MWt: Formula: Purity :
Cevimeline 107233-08-9 HY-70020 199.31 C10H17NOS >MSO
Mechanisms:
Pathways:Neuronal Signaling; Target:mAChR Pathways:GPCR/G protein; Target:mAChR
g y Biological Activity: Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. IC50 value: Target: M3 receptor
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Caution: Not fully tested. For research purposes only Medchemexpress LLC
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