Observation of X-ray variability in the BL Lac object 1ES1959+65

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全功能荧光显微镜简介英文AS_69066_TG_611900_GB_1124-1

全功能荧光显微镜简介英文AS_69066_TG_611900_GB_1124-1

CAPTURING HIGH-RESOLUTION IMAGES
Using the BZ-X700
For large areas that cannot be seen within a single field-of-view, a motorized XY stage can capture and stitch together the entire region of interest in high resolution. Even for tilted specimens or specimens that have height differences, it is possible to create an image in which the entire specimen is in focus. This is accomplished by capturing multiple images in the Z-direction and stacking together only the parts that are in focus. Only the desired cells can be extracted from the whole slice and the proportion can be automatically calculated using Hybrid Cell Count.
Uneven light intensity leads to shading at the seams. Stitch lines are eliminated with shade correction.
n Comparison with conventional software

学者简介生理学科学家实验的故事

学者简介生理学科学家实验的故事

学者简介:生理学科学家实验的故事Claude Bernard: 内环境稳态概念的提出者19世纪法国著名的实验生理学家克劳·伯尔纳(Claude Bernard ,1813—1878),晚年提出“内环境稳态”(internal environment homeostasis )的概念,是其许多重大贡献中最伟大的。

Bernard 提出机体生存在两个环境中,一个是不断变化着的外环境,另一个是比较稳定的内环境。

内环境是围绕在生命有机体细胞周围的体液,深居于机体的内部,为活细胞提供一个适宜的生活环境。

内环境本身很大的一个特点在于它的理化性质变动非常小,例如它的组分数量与功能都是相对恒定的。

他总结出一句话:“内环境恒定是机体自由和独立生存的首要条件。

”这被有识之士认为是Bernard 对生命现象高度概括的具有丰富内容的一句名言。

Claude Bernard and internal environment homeostasisIn 19th century, Claude Bernard, a France famous experimental physiologist, demonstrated the concept of “internal environment homeostasis ”. It is the most important one in his many contributions for physiology. Bernard illustrated the body lived in two environments. One was the variability external environment, another was stable internal environment. Internal environment is present within and around the cells of the body and is called extracellular fluid. Internal environment provides a adequate living environment for the cells of the body. One prominent characteristic of internal environment is variation in narrow range of its physical and chemical characteristic. He conclude internal environment is the primary condition that the body can free and independent survival. Thisconclusion was posited a highly summarily and abundance content saying for the life phenomena by many scientists.External environmentExtracellular fluid: The internal environmentIntracellular fluid of most cells Material enters and leaves the bodyKarl Landsteiner和ABO血型的故事在1900年,维也纳大学病理解剖系的年轻助教卡尔·兰德斯坦纳(Karl Landsteiner, 1868—1943)在他的22位同事的正常血液中,发现红细胞和血浆之间有反应,也就是说,某些血浆能使另一些人的红细胞凝集。

(完整版)医学影像专业英语

(完整版)医学影像专业英语

(1)To prospectively evaluate the effect of heart rate, heart rate variability, and calcification dual-source computed tomography (CT) image quality and to prospectively assess diagnostic accuracy of dual-source CT for coronary artery stenosis. by using invasive coronary angiography as the reference standard.前瞻性评价心率、心率变异性及钙化双源计算机断层扫描成像质量的影响及对冠状动脉狭窄的双源性冠状动脉狭窄诊断的准确性评价。

以侵入性冠状动脉造影为参照标准。

(2)Chest radiography plays an essential role in the diagnosis of thoracic disease and is the most frequently performed radiologic examination in the United States. Since the discovery of X rays more than a century ago, advances in technology have yieled numerous improvements in thoracic imaging. Evolutionary progress in film-based imaging has led to the development of excellent screen-film systems specifically designed for chest radiography.胸部X线摄影中起着至关重要的作用在胸部疾病的诊断,是最常用的影像学检查在美国。

The proposed thesis title is Observations of X-ray Counterparts to Gamma-ray Bursts in

The proposed thesis title is Observations of X-ray Counterparts to Gamma-ray Bursts in

Donald A. Smith MIT Room 37-432 September 14, 1997
The ASM has proven to be more e cient for GRB detection than was previously expected. At present, six GRBs have been positively identi ed in the ASM data by comparison with BATSE and/or Ulysses triggers. A further four events have possible Konus and/or Ulysses counterparts, but they have not yet been unambiguously indenti ed. There remain two further ashes of X-rays that may be GRBs unobserved by other instruments. The criteria used to isolate these events are (1) variability in the time series data (1=8-s resolution) in a 90-s dwell, and (2) the detection of a new source with high signi cance (and goodness of t) in the positional data. Crossed lines of position are available for ve of these fourபைடு நூலகம்een sources because (1) the burst occurred in the region of overlap of the two FOVs or (2) the burst duration was su ciently long in the ASM band for the normal stepping to yield detections in two SSCs during di erent dwells. The latter category includes GRB 970815 and GRB 970828, which were rapidly located by the ASM with error regions of order 20 70 in size (Smith et al. 1997, Remillard et al. 1997). The recent ASM detection and localization of GRB 970828 (Remillard at al. 1997) demonstrated both the potential of the ASM trigger capability and the response time of the ASM/PCA system. Members of the MIT team identi ed an ASM transient TOO alarm as a likely GRB and obtained a 60 position within 2 hr of the burst. The PCA, 4-m Herschel telescope, and the VLA were all on target 4 h after the burst. This was all accomplished with much human intervention. We are developing a comprehensive set of interacting software to identify, localize and report on bright, isolated GRBs within tens of minutes of the initial trigger. Although the ASM is proving e cient at agging bright transient X-ray events, the identi cation of a transient source as a GRB is clari ed when a real-time GCN (formerly BACODINE) burst notice is received and the (large) gamma-ray error box includes the region being viewed by the ASM. The BATSE catalog can also be used in conjunction with the ASM to put upper limits on the rate of GRB intensity decay. The ASM typically scans over any given spot on the sky within 2 ? 12 hours of a given trigger time. BeppoSAX has detected X-ray afterglow 6 ? 8 hours after a few gamma-ray bursts at an intensity of > 10 Crab. The ASM can achieve at best a sensitivity of 5 mCrab, so we would not be able to repeat their detections, but it is important to perform a comprehensive search, to verify that there are no exceptionally bright afterglows, that no bursts repeat within the mission duration, and that the BeppoSAX bursts were typical. I therefore propose to use the full capabilities of the ASM to determine location, variability, and spectral characteristics of the X-ray counterparts to gamma-ray bursts. I believe these e orts will represent a useful contribution to the eld of Physics.

X-ray 辐射X射线英文PPT

X-ray 辐射X射线英文PPT

X - ray irradiation 射线的照射
Penetrating Action 穿透作用
Ionization Effect 电离作用
Biological response 生物反应
Application method Application examples 应 用 例
Measure 测量
Non-destructive Inspection 非破坏检查
・Concentration measurement 浓度计测 ・Density measurement 密度计测
・ X light perspective X光透视
・ CT detection CT检查
Diagnosis 诊断
・X - ray radiography X射线造影
Radiation
Ezreal & Allen
Vocabulary
X-ray:X射线 X-ray spectrum:射线谱 Coherent scattering:相干散射 Incoherent scattering:非相干散射 attenuation of X-ray: X射线的衰减 Absorb of X-ray: X射线的真吸收 Optic-electric effect:光电效应 fluorescent radiation:荧光辐射
h = Planck's constant = 1.38 10-16 erg sec
X-Ray Tubes
X-Ray Tubes
1-高压变压器;2-钨丝变压器; 3-X射线管;4-阳极; 5-阴极;6-电子;7-X射线
7 3
5
6
4 2
1
Application of X-ray

BasicConceptsofMedicalInstrumentation医疗器械的基本概念-46

BasicConceptsofMedicalInstrumentation医疗器械的基本概念-46

Measurand: Physical quantity
• Biopotential • Pressure • Flow • Dimensions (imaging) • Displacement (velocity, acceleration, force) • Impedance • Temperature • Chemical Concentration
Medical Research Studies
- Observational: Characteristics of patients are observed
and recorded -Case-series: describe characteristic of group -Case-control: observe group that have some disease -Cross-sectional: Analyze characteristics of patients -Cohort: determine if a particular characteristic is a precursor for a disease.
be less sensitive to interference. (preferred) 1. Adding new components designed to offset the
undesired inputs.
1.7 Compensation Techniques
• Inherent Insensitive
1.3 Sampling and Continuous Modes
• Sampling and collecting data will depend on the following:

(完整版)医学影像专业英语

(完整版)医学影像专业英语

(1)To prospectively evaluate the effect of heart rate, heart rate variability, and calcification dual-source computed tomography (CT) image quality and to prospectively assess diagnostic accuracy of dual-source CT for coronary artery stenosis. by using invasive coronary angiography as the reference standard.前瞻性评价心率、心率变异性及钙化双源计算机断层扫描成像质量的影响及对冠状动脉狭窄的双源性冠状动脉狭窄诊断的准确性评价。

以侵入性冠状动脉造影为参照标准。

(2)Chest radiography plays an essential role in the diagnosis of thoracic disease and is the most frequently performed radiologic examination in the United States. Since the discovery of X rays more than a century ago, advances in technology have yieled numerous improvements in thoracic imaging. Evolutionary progress in film-based imaging has led to the development of excellent screen-film systems specifically designed for chest radiography.胸部X线摄影中起着至关重要的作用在胸部疾病的诊断,是最常用的影像学检查在美国。

数字X线摄影系统

数字X线摄影系统
CCD摄像机在提高空间分辨力、改善信噪比和减少伪影等方面均有长足的进步,取代了真空摄像管. 这种系统的主要缺陷: 1.由子I.I和摄像管中的光散射和电子散射, 引入了附加的对比度损失; 2.电视摄像管的动态范围小,不能发现微小 的组织差异; 3.I. I的视野小,边缘和中心分辨力不一致.
“骨肉分离”,分别观察骨组织和软组织
FDA Approved
第二代功能DR
能量减影 – 病例 1
第二代功能DR
能量减影 – 病例 2
第二代功能DR
平板读出时间0.13S,其他数字平板探测器的读出时间至少1.25S,甚至达15秒以上 DR能量减影、断面三维合 成及图像拼接技术的基础 血管机连续采集成像的基础
二、直接X线数字摄影装置(DDR)
DDR指采用一维或二维X线探测器直接把X线转换为模拟电信号进行数字化的方法,不同于先获得模拟图像,再对模拟图像进行数字化的方法。 平板型探侧器 (flat panel detector,FPD)DDR。
二、直接X线数字摄影装置(DDR)
二、直接X线数字摄影装置(DDR)
三、DDR使用的探测器
2.非晶态硒型平板探测器:主要由集电矩阵、硒层、电介层、顶层电极和保护层等构成.集电矩阵由按阵元方式排列的薄膜晶体管(thin-film transistor, TFT)组成,非晶态硒层涂覆在集电矩阵上,它对X线敏感,并有很高的解像能力。
非晶态硒型平板探测器
偏压
第二代功能DR
Tissue Equalization(组织均衡) Dual Energy Subtraction (能量减影) CAD---Computer Aided Detection (计算机辅助诊断)
DR的高级临床应用功能
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a rXiv:as tr o-ph/23335v12Mar22Observation of X–ray variability in the BL Lac object 1ES1959+65Berrie Giebels 1,Elliott D.Bloom,Warren Focke,Gary Godfrey,Greg Madejski,Kaice T.Reilly,Pablo M.Saz Parkinson,Ganya Shabad Stanford Linear Accelerator Center,Stanford University,Stanford,CA 94309Reba M.Bandyopadhyay 2,Gilbert G.Fritz,Paul Hertz 3,Michael P.Kowalski,Michael N.Lovellette,Paul S.Ray,Michael T.Wolff,Kent S.Wood,Daryl J.Yentis E.O.Hulburt Center for Space Research,Naval Research Laboratory,Washington,DC 20375and Jeffrey D.Scargle Space Science Division,NASA/Ames Research Center,Moffett Field,CA 94305-1000ABSTRACT This paper reports X–ray spectral observations of a relatively nearby (z =0.048)BL Lacertae (BL Lac)object 1ES1959+65,which is a potential TeV emit-ter.The observations include 31short pointings made by the Unconventional Stellar Aspect (USA)Experiment on board the Advanced Research and Global Observation Satellite (ARGOS),and 17pointings by the PCA on board the Rossi X–ray Timing Explorer (RXTE).Most of these observations were spaced by lessthan 1day.1ES1959+65was detected by the ARGOS USA detector in the range 1-16keV,and by the PCA in the 2-16keV range but at different times.During the closely spaced RXTE observations beginning on 2000July 28,an ending of one flare and a start of another are visible,associated with spectral changes,where the photon index Γranges between ∼1.4and 1.7,and the spec-trum is harder when the source is brighter.This implies that 1ES1959+65is anXBL-type blazar,with the X–ray emission likely to originate via the synchrotronprocess.The USA observations reveal anotherflare that peaked on2000Novem-ber14and doubled theflux within a few days,again associated with spectralchanges of the same form.The spectral variability correlated with theflux andtiming characteristics of this object that are similar to those of other nearby BLLacs,and suggest relativistic beaming with a Doppler factorδ≥1.6and mag-neticfields of the order of a few mG.We also suggest that the steady componentof the X–ray emission–present in this object as well as in other XBLs–maybe due to the large-scale relativistic jet(such as measured by Chandra in manyradio-loud AGN),but pointing very closely to our line of sight.Subject headings:1.IntroductionOver a dozen BL Lacs have been detected at GeV energies(Mukherjee et al.1997), but only a few nearby BL Lacs have been identified at TeV energies so far.Mkn421 (z=0.031)(Punch et al.1992)and Mkn501(z=0.034)(Quinn et al.1996)are now strongly confirmed sources,seen by more than one ground-based atmosphericˇCerenkov telescope(ACT)at or above the5σlevel.Two more,1ES2344+514(z=0.044)(Catanese et al.1998)and PKS2155-304(z=0.116)(Chadwick et al.1999),have been detected only once and are less conclusive.This strongly suggests that low-redshift X–ray selected BL Lac objects(XBLs)such as these may be the only extragalacticγ-ray sources observable at TeV energies.This is because on the one hand more distant objects would have their TeV emission strongly absorbed by the extragalactic background light(EBL),and on the other bright X–ray emission,presumably originating from synchrotron radiation and thus revealing the distribution of radiating particles,implies even higher intrinsic GeV-TeV emission(see, e.g.Tavecchio,Maraschi&Ghisellini(1998)).The BL Lac object1ES1959+65(z=0.048),is an XBL also present in the third EGRET catalog with an average measuredflux of1.8×10−7photons cm−2s−1for E>100 MeV(Hartman et al.1999).It is thus a natural source for TeV emission,and Stecker,De Jager&Salamon(1996),using simple scaling arguments,have predicted for it the third highestflux above0.3and1TeV,after Mkn421and Mkn501.More recently,Costa-mante&Ghisellini(2001)have also pointed it out as a candidate TeV emitter.Quoting Weekes(1999),the Utah Seven Telescope Array has reported the detection of1ES1959+65 based on57hours of observation in1998(Kajino et al.1999),with an energy threshold of 600GeV.Theflux level was not reported but the total signal was at the3.9σlevel.Thisis not normally considered sufficient to claim the detection of a new source;however,within this database there were two epochs which were selected a posteriori which gave signals above the canonical5σlevel.This source has not yet been confirmed by any other group; it was observed by the Whipple group but noflux was detected(Catanese et al.1997).Of particular interest in this source is also the fact that its distance is of the same order as the two other confirmed TeV sources,making it a good candidate to probe the EBL that can in turn probe cosmological problems such as the formation of galaxies(see e.g.Primack et al.(1999);Guy et al.(2000)).1ES1959+65is also part of a200mJy radio-selected sample at5GHz(Marcha et al.1996;Bondi et al.2001)and it was seen in the Einstein Slew Survey(Perlman et al.1996).Multiple photometric optical values were found in the literature,showing a great variation of the source brightness in the optical band from V=16 to V=12.8.A complete study of the optical band can be found in Villata et al.(2000) where variability on short timescales(a few days)was reported.The capabilities of the USA and the PCA instruments to monitor the X–ray emis-sion are particularly well suited for the detailed study of the X–ray energy spectrum of 1ES1959+65,and its temporal evolution.Here,we present31USA and17PCA observa-tions of1ES1959+65.The PCA data are two sets of intraday observations,obtained from unpublished RXTE archival data,that span a few days in which the end of aflare and beginning of anotherflare are detected.The USA observations are short daily monitoring observations that span7weeks,ending with a strongflare,where the X–rayflux tripled in 7days(the USA data were taken in the context of a multi-wavelength campaign that was not successful in the TeV range due to bad weather at the ACT site).In Section2,we report the details of the observations;in Section3,we report the main features of the data; in Section4,we discuss the implications of the X–ray spectral variability and the quiescent X–ray emission detected in1ES1959+65;we present our conclusions in Section5.2.Observations and Data AnalysisA DataThe USA Experiment observed1ES1959+65about once per day between2000Septem-ber21(MJD51808)and November11(MJD51859).(For a detailed description of the USA experiment see Ray et al.(1999),Wood et al.(2000)and Shabad(2000).)The USA detector was used in the“ping”mode where within one observation the source is pointed at2or3times for T ON seconds and then a background is taken for T OF F seconds,where typically,T ON=T OF F=60seconds and an observation lasted for∼300s(for more details on the“ping”observation mode see Giebels et al.(2000)).This type of observation hasthe advantage of not relying on a background model but rather on a direct measurement of the background,but results in some loss of signal within an observation A data were extracted from FITS formattedfiles using CFITSIO.Care was taken to use an OF F position as devoid as possible of bright X–ray sources,and at least2◦away from the source. Observations were made in low background regions of the orbit,where the counting rate was approximately30cts/s or1%of the Crab level in the same conditions.The segments of the observation where the background is too high,especially at the beginning and the ending of each observation,are rejected.For the present investigation,we use only observations where at least2pairs of ON-OFF pointings are available for each observation.Within those restrictions,31observations were used from which∼16ks of data were selected.We present the X–ray lightcurve for1ES1959+65in Figure1;in that Figure,the stan-dard deviation of the average in the background was added in quadrature to the error on the count rate for each observation.The data were then corrected for obscuration by the instrument support structure when necessary,and also for the collimator response.Every point in the lightcurve is a single observation.The lightcurve(normalized to the USA Crab rate in the energy range defined below,or3500cts/s)for the total range is shown in the top panel of Figure1.The data were taken in the spectral mode,where the instrument integrates a spectrum covering an energy range of approximately1–17keV in48pulse height analyzer(PHA) channels every10ms.In this work,we make no use of the lowest(0)and the highest(47) PHA channels;the PHA channels1–46(∼1−16keV)are referred to as the total USA range. The spectral characteristics of the time series were studied by dividing the USA data into two energy bands,the PHA channels1–10(soft band)and11–46(hard band),corresponding to approximately1–3keV and3–16keV,respectively.A hardness ratio,shown in the second from top panel in Figure1,is the ratio of the counting rate in the hard band over the soft band.The dates are given in Modified Julian Date(MJD)−51000.2.2.RXTE/PCA DataUnpublished PCA data of1ES1959+65were obtained from the RXTE data archive. The RXTE/PCA observed1ES1959+6512times from2000July28through August2, and5times between2000September1–6,with exposures of∼900s in the July-August observations and a few ksec each in September.The STANDARD2data were extracted using the HEASARC ftools andfiltered using the RXTE GOF-recommended criteria(layer1only, for better signal to noise,PHA channels0to27(lightcurves only)or approximately1-10keV, Earth elevation angle greater than10degrees,pointing offset less than0.02degrees,timesince the peak of the last SAA passage greater than30minutes and electron contamination less than0.1).The lightcurve and spectral data are from unit2(PCU2)only since a faint background model is not yet available for unit0during gain epoch5.The background models of Epoch4were used.Lightcurves were extracted using the ftools saextrct(through the rex script)and lcurve.The variable PCA background was modeled with pcabackest, which uses observations of X–ray blank,high latitude areas of the sky(Jahoda et al.1996). Spectralfits were done using XSPEC v.11.0.1and response matrices generated by the ftool pcarmf.The source was not detected with a better significance than∼2σwith the RXTE/HEXTE instruments.A likely explanation is the steep spectrum,derived from the PCA data,that falls below the HEXTE sensitivity.2.3.Archival DataAn observation with the BeppoSAX instrument in1997(Beckmann2000;Beckmann& Wolter2001)resulted in a measuredflux of1.3×10−11erg cm−2s−1in the2–10keV band and a spectral index ofα=1.64.Thisflux is an order of magnitude fainter than the brightest flux measured here by the PCA.However,the results published by(Beckmann2000)should be treated with caution,as there is an apparent error in the value of the Galactic column adopted by them(they adopt1020rather than1.027×1021atoms cm−2adopted by us on the basis of the COLDEN program available as a part of the Chandra Proposal Planning Toolkit,based on relatively reliable21cm data).The analysis of the PSPC All-Sky Survey data by those authors implies that assuming a simple power law,thefitted absorption is 1.6×1021atoms cm−2,somewhat larger than the Galactic value.However,this might be because the intrinsic X-ray spectrum steepens somewhat towards higher energies,as is often the case for other XBL-type blazars,and an assumption that the observed spectrum is a simple absorbed power law overestimates thefitted absorption.Note that the higher column density makes no difference in the results from the USA or RXTE data.The Einstein Slew Survey Sample of BL Lac Objects(Perlman et al.1996)quotes aflux of3.65µJy at2keV, which is∼40%brighter than the BeppoSAX measurement.We also extracted the ROSAT HRI archival data for this source,and used the ROSAT all-sky data.ROSAT HRI observed it on1996April1;the observation lasted for a total of half a day,yielding about2800sec of good data.The data were reduced in a standard manner,revealing that the net source counting rate was∼1.57ct s−1,with no indication of variability,but this is not too surprising given the short observation length.The conversion of the HRI count rate toflux is dependent on the source spectrum,which has to be assumedas there is essentially no spectral information in the HRI data.Since we do not know the soft X-ray spectrum at the epoch of the HRI observation,we assume the energy indexα=1.5, but two different values of N H,the Galactic value of1021cm−2and thefitted ROSAT value of1.6×1021cm−2.To obtain the conversion from the HRI counting rate to the observedflux, we used the PIMMS tool provided by HEASARC(and checked the results using XSPEC with the HRI effective area curve).Assuming the Galactic column of1021cm−2,we obtain the0.1-2.4keVflux of5.5×10−11erg cm−2s−1and1-2keVflux of2.2×10−11erg cm−2 s−1.Assuming thefitted ROSAT value of1.6×1021cm−2,we infer the0.1-2.4keVflux of5.4×10−11erg cm−2s−1and1-2keVflux of2.5×10−11erg cm−2s−1.In any case, this corresponds to(roughly)2mCrab,which is lower than the13mCrab level from the Rosat all-sky Survey Bright Source Catalog(1RXS-B).This simply implies that during the ROSAT survey,1ES1959+65was significantly brighter than during the Einstein,ROSAT HRI or BeppoSAX observations,and the episodes of highflux as seen by the USA or RXTE observations described hereafter are not unique.3.Observational Results3.1.Flares in the USA and RXTE DataThe USA and RXTE observations of1ES1959+65conducted from July through Novem-ber2000show that the source was bright and variable in the X–ray band,with the X–ray spectrum significantly harder than observed during the periods of lower brightness.Specifi-cally,these data show that during the last quarter of2000,1ES1959+65underwent an X–ray flare reaching the12mCrab level in the1-16keV band on November14(MJD51863).Vari-ability of a factor∼6was detected within20days,and a factor∼3within7days(Figure1). By comparison,the peakflux detected by USA on Mkn421in2000reached approximately 40mCrab at maximum.Visual inspection of the USA(as well as the RXTE)lightcurves, and in particular of the largestflare,indicates that the source does not appear to vary sig-nificantly on timescales shorter than a day;thus the variability is not undersampled.These observations show that1ES1959+65was in a variable state for at least4months.To com-plete the coverage of thisflare,3data points from the RXTE/ASM were normalized to the Crab and added to the lightcurve in Figure1;this shows theflare continuing to decrease. The varying spectral index and differences in the energy response of both instruments com-plicate the comparison.Nonetheless,the full-width at half-maximum region of theflare with these additional points spans5±1day,and the doubling time is2.5days.The PCA archival data obtained2months prior to the USA observations show65%flux changes in3.5days;the highest observed value was F(2-10keV)=1.4×10−10ergcm−2s−1,but the peak value is unknown,since the observed maxima are at the endpoints of the observed period,when the source was falling or rising as shown in Figure2.The USA lightcurve shows that the PCA did not cover the typical variation period which appears to be>4days.The samefigure shows a decreasingflux extending over3.5days,and after30 days observations resume for4days where a steady increase offlux is seen.Theflux did not change more than a few percent on timescales shorter than a day in the PCA data.In the three panels in Figure3it is apparent that variations are larger in the harder bands in the decreasing part of the PCA observations.3.2.Flux-Spectrum CorrelationsThe PCA data were used to perform spectralfits as a function of theflux in the2-10 keV energy range.The data werefit to a single power-law function with indexα,such that the photonflux N(E)=N0E−(α+1)and the absorbing column N H=10.27×1020cm−2.The absorbed power law model provides an adequatefit for all RXTE PCA pointings. Spectral indices were obtained for every observation,and in some cases,intraday observations where the estimated indices andfluxes were similar were added together to improve the significance on a daily timescale.The spectralfits are shown in Table2along with the month,day and fraction of the day of the beginning of each observation.The X–ray spectrum follows a“loop”in the spectral index-flux plane,as seen in Figure 4,and it is not surprising that the X–ray spectrum shows significant evolution during the flare given that there is a more rapid rise and drop in the hard X–ray band(see§4for discussion).The steepest spectrum in the PCA data was observed at thefirst observations in the declining phase July28(α=1.68),and the hardest spectrum was seen on2dates separated by a month and at a similarflux(α=1.37)which is a hint that the same physical mechanism is generating theseflux variations.In the case of the USA observation, poorer photon statistics and an incomplete energy calibration limited the spectral study to a hardness ratio(HR)estimation plotted on the same Figure1.The USAfluxes and HR are shown in table1.During the strongestflare,that started around(MJD-51000)=857,a20% variation in the HR is observed.4.Discussion4.1.Doppler Boosting of the Flux of1ES1959+65The electromagnetic emission in blazars is very likely to be Doppler-boosted(or beamed) towards the observer.In the radio regime,the evidence comes from superluminal expansions observed with VLBI.Similar superluminal expansions have now been seen in the optical band with the HST in nearby galaxies such as M87.Relativistic beaming is also required in order to avoid absorption of GeV photons by X–ray photons via the e+/e−pair-production process. It is thus possible to use the X–ray variability data as well as the fact that1ES1959+65is an EGRET-detected BL Lac object,to establish a limit for the Doppler factorδ,withδdefined in the standard way as[Γ(1−βcosθ)]−1,whereΓis the bulk Lorentz factor of the plasma in the jet,β=v/c andθis the angle to the line of sight.Assuming that theγ-rays and X–rays from1ES1959+65are produced in the same region,it is possible to calculate the opacity for pair productionτγγfrom the source sizes inferred from the USA and RXTE/PCA data.The formula given by equation(3)in Mattox et al.(1993)for the optical depth for an outflow which is nonrelativistic in its comoving frame,as corrected by Madejski et al.(1996),isτ=2×103(1+z)2α(1+z−√µJy(EγThe X–ray data presented above imply that the X–ray spectrum of1ES1959+65hardens as the source brightens.This is often measured in BL Lac objects;a hardening of the spectrum whenflares occur,and a blueward shift of the peak of the synchrotron emission (and presumably higher energy inverse-Compton emission)by factors that can be as large as100was measured in the cases of Mkn501(Pian et al.1998),1ES1426+428and PKS 0548−322(Costamante et al.2001).In the case of PKS2005-489(Perlman et al.1999),a more moderate shift of a factor of3or less of the synchrotron emission was found.4.2.Synchrotron Models and Inferred ParametersThe spectral change is best illustrated as a correlation betweenflux and the photon ing PCA data this correlation is illustrated in Figure4.Even though the two observations were separated by a month and are certainly related to two differentflares,it is still interesting to compare this spectral evolution since the time series have similar rise and fall timescales,which are also comparable to what is seen in the USA detector.It is thus likely that the twoflares originate from a similar mechanism and that the correlation plot has some validity.The“clockwise motion”(shown with arrows)observed in the data for1ES1959+65 has also been seen inflares in Mkn421(Takahashi et al.2000,1996),in PKS2155−304 (Sembay et al.1993)and in H0323+022(Kohmura et al.1994),although in some cases counterclockwise patterns have also been seen(Mkn501,Catanese&Sambruna(2000)). The spectrum steepens more rapidly than theflux in the declining phase and hardens rapidly in the brightening phase,indicating that the variations of the hard X–rays occur faster than those in the soft X–rays both during the increase and the decrease of the brightness of the source.The spectral index change of14%seen here is comparable to the10%seen in Mkn421.The variation observed in theflux-index plane can provide information about the acceleration process(Kirk&Mastichiadis1999).Counter-clockwise patterns are expected when acceleration,variability and cooling timescales are similar in aflare.In this case the acceleration process proceeds from low energy to high energy changing the number of particles and making the softer energies varyfirst.Clockwise patterns,where the harder energies varyfirst,can be explained inflares where the variability and acceleration timescales are much less than the cooling timescale.For a homogeneous emitting region,the radiative lifetime of a relativistic electron emitting synchrotron photons with energy E keV is(in the observer’s frame)τsync=1.2×δ−1/2s(Rybicki&Lightman1979).This should give some estimate of the 103B−3/2E−1/2keVmagneticfield B,even though the extent to which the timescale of theflux decrease was due to the propagation of the signal throughout the source and to what extent it was causedby the synchrotron cooling is not known.However,it is possible to measure the relative decrease of theflux∆F/F in three energy bands in a time∆T using the PCA data as seen in Figure3.To estimate the timescale for a drop by a factor of two in each energy band, the measured timescale is divided by a factor2∆F/F.The factor∆F/F is smallest for the lowest energy band(24%)as expected.It is now possible tofindτ1/2(E)=7.7,4.9and 1.9×105s,respectively,for3,7and12keV photons.According to Takahashi et al.(1996) we writeτsync(E)−τsync(12keV)=1.2×103B−3/2δ−1/2(E−1/2keV−12−1/2).Comparing the decline of theflux of3keV and12keV photons yield B=0.007δ−1/3G,while the decay of the7keV and12keV photons yield a similar result of B=0.005δ−1/ingδ=1.6we infer B=4×10−3G.It is interesting to note here that this is a similar value to that found by Perlman et al.(1999)(P99hereafter)in an outburst of PKS2005−489where variability on timescales of days was observed.The peak observed frequency of the synchrotron emissionνs of an electron withγel is given byνs≃1.2×106Bγ2elδ−ing the magneticfield inferred above,the Lorentz factors of the electronsγel radiating at energy E can be estimated from E=2×10−14γ2elδkeV.This implies thatγel of electrons4radiating in the X–ray band is∼107.The value of B calculated as above is significantly lower than0.2G,andγel higher than5×105inferred for Mkn421by Takahashi et al.(1996),but the values inferred by us are similar to those quoted for PKS2005−489by P99where a possible undersampling was invoked to explain the possibility of faster(shorter than∼1day)variability,which in turn would make the inferred value for B a lower limit andγel an upper limit.We believe that in1ES1959+65theflux is sampled relatively densely,and thus the variability is unlikely to be undersampled.This means that the difference in the inferred values of B andγel in1ES1959+65as compared to Mkn421is unlikely to be a result of the source being more compact,while this could be the case for the potentially undersampled data for PKS 2005−489(P99).With our inferred source parameters being so close to the values found for PKS2005−489,it is now quite possible that real differences between these two sources and Mkn421exist.A conclusive test of the physical parameters in this source would be a clear detection of the TeVγ-ray emission,and any correlation with the X–rayflux.Also, longer,more sensitive and well-sampled observations in the X–ray band are needed to either confirm or disprove that the variability pattern of1ES1959+65and its spectral properties are as described here.A noticeable difference between PKS2005−489and1ES1959+65is that whereas in the latter a variation in the spectral index∆α=0.6was associated with aflux change of a factor of30,in the former a∆α=0.35produced only a65%change intheflux.Also note in the USA data,a doubling of the hardness ratio is accompanied by a factor of6increase influx.4.3.Continuous Emission:Knot Radiation?The USA lightcurve exhibits a non-zero X–rayflux outside of theflaring events of a few10−11erg cm−2s−1(or a few mCrab,taking1Crab≈1.7×10−8erg cm−2s−1in the 2–10keV band).The existence of a steady underlying emission in at least one other BL Lac object,Mkn421,has been invoked in order to obtain meaningfulfits with an exponential decay to X–rayflares(Fossati et al.2000).It is intriguing to investigate if such steadyflux could originate in more extended jets such as those recently resolved by the Chandra and XMM telescopes,but aligned more closely to our line of sight and thus brighter.Such knots (or hotspots)in large-scale(hundreds of parsecs or more)jets have indeed been seen from radio to X–ray energies in many non-aligned sources i.e.sources where the jet is sufficiently misaligned to allow us to resolve the structure of the jet;of course such structures must also originate on a relatively large spatial scale as compared to the sub-parsec jets responsible for the rapid,day-scale variability.These knots are persistent structures visible on timescales of years,and individual spectral energy distributions(SEDs)have been established for knots in multiple sources such as M87(Marshall,Miller et al.2001)or PKS0637−752(Chartas et al.2000).Theirfluxes are usually a fraction of theflux arising from the unresolved core,but a closer alignment to our line of sight than for those sources resolved by Chandra and XMM would result in greater Doppler boost and could provide a continuous background seen in BL Lac-type objects,presumably the objects most closely aligned to our line of sight.To verify if aflux of a few10−11erg cm−2s−1could originate from aligned X–ray knots, somefluxes are taken from the literature for the cases where the angles to the line of sight(θhereafter)and Lorentz factors are available from radio observations.With this,it is possible to estimate theflux enhancement forθ∼0◦and the luminosity at a distance similar to that of1ES1959+65.The observedflux would depend on three factors:•A change in Doppler boost that multiplies theflux F by(˜δ/δ)4(see Urry&Shafer(1984) for luminosity conversions)where˜δis the Doppler factor for the same source but with an angleθ=0◦.Thus the amplification would be[1−βcosθΓ2•The distance difference changes theflux by a factor of(z/0.048)2•a K-correction has to be applied since the bandwidth is narrowed,changing theflux bya factor of(1+zparison with3C66B3C66B is a low-luminosity FRI radio galaxy(z=0.0215).Its jet has knots resolved inthe radio,optical and X–ray band(Hardcastle et al.(2001)and references therein).FromGiovannini et al.(2001)wefind thatθseems well constrained(about45◦)but thatΓis not(between1and7).The set(θ,Γ)∼(45◦,7)is a possible configuration of the jet that would come withinthe right order of magnitude to explain the origin of the X–ray radiation by IC scattering ofseed photons from a hidden BL Lac in the nucleus of3C66B.From Hardcastle et al.(2001)theflux density at1keV,for the2brightest knots out of5(A and B),is approximately10nJy.A value ofα=1.31is used,the one found for the jet,though the exact value doesnot matter much given the comparable redshift of3C66B to the one of1ES1959+65.Theinferred value of A∼1.6×105yields∼4×10−9erg cm−2s−1(or230mCrab)offlux comingfrom the knots in the case of an angle at0◦.Using an angle of∼4◦would reduce thefluxratio by a factor of2only and make it still a bright steady source.The level of expectedradiation in this case is actually so high that a similar object pointing closer to the line ofsight would not be unnoticed in radio emission,thus the(θ,Γ)∼(45◦,7)set seems quiteextreme.Taking a slower jet(β∼0.75)also mentioned in Hardcastle et al.(2001)thefluxcoming from the knots of3C66B would be a factor of6×104lower than in the previouscase,significantly below the level of a few10−11erg cm−2s−1.The results from M87and3C66B show that it is possible that radiation from knotsmoving close to the line of sight can generate a significant fraction of the baseline level of X–rayflux invoked in at least two cases,Mkn421and1ES1959+65here,assuming they containknots similar to those observed in M87or3C66B.Recent VLBI observations show that theline of sight angle with Mkn421is constrained to be in the0◦−30◦range(Giovannini et al.2001),thus a small angle to the line of sight is a possibility for this source.In a moregeneral way,UPS91predict that FR I radio galaxies should have jets with bulkflow speedsin the range fromΓ∼5to∼35,with most nearΓ∼7,and they derive a critical angleθcrit∼10◦for the FR I/BL Lac division.If bright knots are common in BL Lac objects then the amplification factors associated with the large Lorentz factors invoked here could generate a continuous background at the level mentioned above(assumingθis of the order of a few degrees only).A more thorough search for evidence of continuous emission in blazars and other signatures of boosted knot radiation is currently under way.。

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