07_实验记录常用英文表达句型

实验记录常用英文表达句型

一、 加料过程常用表述

1.添加试剂

2.催化量的

3.气体保护

4.通入气体

5.通过双针头导管加料

6.通过注射器加料

二、 反应过程常用表述

1.反应检测

2.放置过液

3.甲苯/乙醇带水

4.氢化反应

5.分水器

6.反应放热

7.微波反应

三、 后处理过程常用表述

1.过滤

2.淬火

3.磨碎

4.在两相中分开

5.静止固化

6.在冻干机冻干

7.纯化

过柱

制备HPLC纯化

制备TLC纯化

重结晶

8.调PH

9.萃取

10.浓缩

11.干燥

干燥

真空干燥

四、 部分常见反应现象描述

1.加料放热

2.反应过程中或者降温有固体析出

3.加料不溶解

4.反应变粘稠/变色

五、 特殊结果叙述

1.无进一步处理

2.统一和其他批次一起后处理

3.检测条件，不需要后处理

一、加料过程常用表述

1.添加试剂

To a mixture (suspension / solution / slurry) of compound 12 (487 mg, 1 mmol) and o-plenylenediamine (948 mg, 6 mmol) in CH2Cl2 (15 ml) being coolen to 0℃ was added the DCC (226 mg, 1.1 mmol).

Anhydrous lithium iodide (1.38 g, 10.3 mmol) was added the five portions (dropwise / in one portion / in portions) to a stirred solution of compound 12 (10.90 g, 51.5 mmol) in CH2Cl2 (120 ml).

A round-bottom flask was changed with compound 3 (1.75 g, 5.27 mmol), LiCl (1.17 g, 26.3 mmol), DMSO (100 Ml) and H2O (378 ul)

分批加入 in portions/portionwise

一次性加入 in one portion

滴加 dropwise

2.催化量的

Et3N (20 mL, 142 mmol) and a catalytic amount of DMAP were added the solution of compound 1 (4.549 g, 46.4 mmol) in CH2Cl2（120 ml） at 0℃

3.气体保护

To a stirred -78 solution

℃of trimethylsilyacetylene (4.44g, 45.5 mmol)in THF (10 ml) under argon was added dropwise n-butylithium (1.6M in hexane, 28.25 ml).

4.通入气体

An ozone-enrichen steam of oxygen was bubbled through a cold (-78) solution of

℃compound 9 (128 mg, 1.409 mmol) in CH2Cl2 (5 ml) until it turned light blue. The

℃3 . solution was purged with argon at -78 for 10 min to remove the excess O

5.通过双针头导管加料

The mixture was added to a sulotion of compound 2 (3.00 g, 12.8 mmol) in THF (48 ml) via cannula over a period of 30 min.

A solution of compound 29 (100 mg, 0.19 mmol, 1.0 equiv) in dry DMSO (1.5 ml) was cannulated under argon to a vigorously stirred mixture of powered potassium superoxide (62 mg, 0.87 mmol, 4.5 equiv) and 18-crown-6-ether (23 mg, 0.087 mmol, 0.45 equiv) in dry DMSO （0.5 ml）.

6.通过注射器加料

To a stirred solution of compound 15 (8.61 g, 21.2 mmol) was added a solution of p-toluenesulfonic acid (6.0 g) in CH2Cl2 via syringe over 5 min.

7. 反应控温

A solution of compound 1 (10 g, 1 mol) in EtOAc (20 ml) was added dropwise (via addition funnel or syringe) to the above mixture at 10 ℃

(while maintaining gentle reflux;

℃.

while keeping internal temperature between 10 ℃ - 30)

二、反应过程常用表述

1. 常温/回流搅拌

℃

a.The reaction mixture (solution or suspension) was stirred at 5 for 2 hrs and

then kept at room temperature (or ambient temperature) for another 2 hrs (or overnight)

b.The reaction mixture (solution or suspension) was refluxed (or heated to reflux)

for 2 hrs (or overnight)

℃

c.The reaction mixture (solution or suspension) was heated at 60 for 2 hrs (or

overnight)

d.The reaction mixture (solution or suspension) was allowed to reflux (or heat to

reflux) for 2 hrs (or overnight)

2. 反应检测

a. After 1 h, TLC analysis (CH2Cl2 / hexane 3:1) showed the complete consumption of compound 15.

b. The reaction was complete (incomplete or messy) detected by TLC (Petroleum ether/EtOAc = 4:1),LC-MS, HPLC or NMR.

3. 放置/过夜

The mixture was left standing overnight.

The mixture was allowed to stand at room temperature for 1 day.

℃

The mixture was allowed to stand in a freezer at -15 .