Targeted-cryosurgical ablation of the prostate with androgen deprivation therapy： quality of li

冷冻消融与外科手术治疗肺癌的现状

年，ＣＯＰＰＥＲ
［２］
首先采用液氮冷冻治疗恶性肿瘤；
根据２０１８年第５版美国国家综合癌症网络
中国肿瘤外科杂志２０１９年１２月第１１卷第６期ＣｈｉｎＪＳｕｒｇＯｎｃｏｌ，Ｄｅｃｅｍｂｅｒ２０１９，Ｖｏｌ．１１，Ｎｏ．６
· ４７１·
（ＮＣＣＮ）非小细胞肺癌指南推荐，手术治疗主要适
进步，但这一进步的很大一部分在于改善了开放手
期、Ⅱ期以及部分ⅢＡ期的肺癌患者。值得关注的
肺叶切除术与保留肌肉的胸廓切开术相比较似乎
应证为肺癌ＴＮＭ分期中相对早期肺癌患者，如 Ⅰ
是尽管随着肺癌综合治疗方式的不断改进，手术切
除的适应证不断放宽，但中晚期患者手术治疗效果
并不理想。
术技术和围手术期管理。Ｋｕｒｉｔｚｋｙ等［１０］比较ＶＡＴＳ
不可忽视的是冷冻消融作为微创治疗方式在肺癌的
微创理念的不断深入，人们对于微创治疗需求不断增Biblioteka 治疗中显示了其独特的优越性。
长，于２０世纪９０年代初期，以电视胸腔镜手术
１外科手术治疗
治疗的常规术式。冷冻外科治疗最早开始于１９６３
１１适应证
（ＶＡＴＳ）为主的微创胸外科应运而生，现已成为肺癌
· ４７０·
中国肿瘤外科杂志２０１９年１２月第１１卷第６期ＣｈｉｎＪＳｕｒｇＯｎｃｏｌ，Ｄｅｃｅｍｂｅｒ２０１９，Ｖｏｌ．１１，Ｎｏ．６
综述与讲座
冷冻消融与外科手术治疗肺癌的现状
付永强，刘冰
作者单位：１３０１１７吉林长春，长春中医药大学临床医学院（付永强）；１３００２１吉林长春，吉林省人民医院

肿瘤靶向治疗英语

肿瘤靶向治疗英语Targeted Therapy for CancerTargeted therapy for cancer is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells without harming healthy cells. Unlike chemotherapy, which can affect both cancerous and healthy cells, targeted therapy is designed to be more precise and less toxic.There are several different types of targeted therapy, including:- Monoclonal antibodies: These drugs are designed to bind to specific proteins on the surface of cancer cells, making it easier for the immune system to recognize and attack those cells.- Small molecule inhibitors: These drugs are designed to block specific pathways or signals that cancer cells use to grow and divide.- Immunotherapy: This type of targeted therapy helps to boost the body's immune response to cancer cells.- Gene therapy: This is a newer form of targeted therapy that involves modifying the genes within cancerous cells to make them more susceptible to treatment.Targeted therapy can be used to treat many different types of cancer, including lung cancer, breast cancer, and melanoma. It can be used alone or in combination with other treatments, such as chemotherapy or radiation therapy.Overall, targeted therapy offers a promising new approach to the treatment of cancer, with fewer side effects and better outcomes than traditional chemotherapy. However, it's important to remember that each patient's case is unique, and that the best treatment approach will depend on a variety of factors, including the type and stage of cancer, the patient's overall health, and their individual preferences and goals for treatment.。

在未来研制出抗癌药物的作文

在未来研制出抗癌药物的作文英文版In the future, the development of anti-cancer drugs is crucial for the advancement of medical science and the improvement of human health. Cancer is a complex and devastating disease that affects millions of people worldwide. It is characterized by the uncontrollable growth of abnormal cells in the body, which can spread to other parts of the body and cause serious harm.The current treatments for cancer, such as chemotherapy and radiation therapy, can be effective in some cases, but they often come with severe side effects and are not always successful in eradicating the disease. That is why the development of new and improved anti-cancer drugs is so important.Scientists and researchers are constantly working to discover and develop new drugs that can target cancer cells more effectively and with fewer side effects. These drugs may work by blocking the growth of cancer cells, stopping the spread of the disease, or triggering the immune system to attack and destroy cancer cells.In recent years, there have been significant advancements in the field of cancer research, leading to the development of targeted therapies and immunotherapies that have shown great promise in treating various types of cancer. These new drugs are more precise in their targeting of cancer cells, leading to better outcomes for patients and fewer side effects.As we look to the future, the development of anti-cancer drugs will continue to be a top priority for the medical community. With ongoing research and innovation, we can hope to see even more effective and targeted treatments for cancer that will improve the lives of millions of people around the world.中文翻译在未来，研制抗癌药物对于医学科学的发展和人类健康的改善至关重要。

美国氩氦刀

美国氩氦刀一、美国氩氦刀的概念，美国氩氦刀的起源，美国氩氦的工作原理CRYOCARE冷冻手术系统中的CRYOCARE是美国ENDOCARE公司初测商标，意为“冷冻治疗”，音译“快尔克”。

1999年10月，广州张积仁教授和赵国江博士将其命名“氩氦刀”，特指美国Endocare公司的Cryocare冷冻治疗产品，同时将美国Endocare公司发明的Targeted Cryoablation Therapy（TCAP）译为“氩氦靶向治疗技术”。

Cryosurgery冷冻治疗（冷冻手术或低温外科），也称为Cryoablation（冷冻消融），Cryotherapy（冷冻疗法），Cryosurgical Ablation（冷冻手术消融）等，是利用超低温选择性原位冷冻和摧毁病变组织的方法。

冻治疗是人类历史上最早使用的肿瘤微创消融技术，起源于19世纪中叶。

1845年，科学家首次在实验室制出低温。

英国医生James Arnott于1845年用低至-24°C的冰盐水治疗溃疡性肿瘤，开创了近代冷冻治疗。

1877年开始，空气、氧气、氢气和氦气被液化。

1907年医生们使用?70°C的干冰（固态CO2）治疗皮肤和浅表肿瘤。

1950年起温度更低的液氮（?196°C）取代干冰成为主要的冷媒，被直接注入各种肿瘤进行治疗。

现代冷冻治疗起源于1960年美国神经外科医生Irving Cooper和工程师Arnold Lee的合作。

他们发明了新型探针状液氮冷冻器，冷冻脑组织。

自此，使用液氮作为冷媒、加热氮气作为热媒的液氮冷冻设备被应用于治疗各种肿瘤。

但液氮设备欠缺准确性、使用不方便和疗效欠佳使冷冻治疗陷于停顿。

合肥凤凰肿瘤医院冷冻治疗的复兴始于上世纪八十年代。

现代冷冻治疗的先驱-美国着名医学家Gary Onik和杰出的低温科学家-加州大学伯克利分校Boris Rubinsky教授（UC Berkeley, CA, USA)合作，于1982年首次利用超声波为冷冻治疗定位和监测，开创了影像引导的冷冻治疗学（image-guided cryosurgery），大大提高冷冻治疗的准确性和可靠性。

[精彩]美国氩氦刀

美国氩氦刀一、美国氩氦刀的概念，美国氩氦刀的起源，美国氩氦的工作原理CRYOCARE冷冻手术系统中的CRYOCARE是美国ENDOCARE公司初测商标，意为“冷冻治疗”，音译“快尔克”。

1999年10月，广州张积仁教授和赵国江博士将其命名“氩氦刀”，特指美国Endocare公司的Cryocare冷冻治疗产品，同时将美国Endocare公司发明的Targeted Cryoablation Therapy（TCAP）译为“氩氦靶向治疗技术”。

Cryosurgery冷冻治疗（冷冻手术或低温外科），也称为Cryoablation（冷冻消融），Cryotherapy（冷冻疗法），Cryosurgical Ablation（冷冻手术消融）等，是利用超低温选择性原位冷冻和摧毁病变组织的方法。

冻治疗是人类历史上最早使用的肿瘤微创消融技术，起源于19世纪中叶。

1845年，科学家首次在实验室制出低温。

英国医生James Arnott于1845年用低至-24°C的冰盐水治疗溃疡性肿瘤，开创了近代冷冻治疗。

1877年开始，空气、氧气、氢气和氦气被液化。

1907年医生们使用?70°C的干冰（固态CO2）治疗皮肤和浅表肿瘤。

1950年起温度更低的液氮（?196°C）取代干冰成为主要的冷媒，被直接注入各种肿瘤进行治疗。

现代冷冻治疗起源于1960年美国神经外科医生Irving Cooper和工程师Arnold Lee的合作。

他们发明了新型探针状液氮冷冻器，冷冻脑组织。

自此，使用液氮作为冷媒、加热氮气作为热媒的液氮冷冻设备被应用于治疗各种肿瘤。

但液氮设备欠缺准确性、使用不方便和疗效欠佳使冷冻治疗陷于停顿。

合肥凤凰肿瘤医院冷冻治疗的复兴始于上世纪八十年代。

现代冷冻治疗的先驱-美国着名医学家Gary Onik和杰出的低温科学家-加州大学伯克利分校Boris Rubinsky教授（UC Berkeley, CA, USA)合作，于1982年首次利用超声波为冷冻治疗定位和监测，开创了影像引导的冷冻治疗学（image-guided cryosurgery），大大提高冷冻治疗的准确性和可靠性。

药物涂层球囊扩张术在下肢动脉硬化闭塞患者中的应用价值探讨

DOI：10.19368/ki.2096-1782.2023.22.009药物涂层球囊扩张术在下肢动脉硬化闭塞患者中的应用价值探讨王茂生，王伟，任洪，黄丽琼，晏明鹏云南省曲靖市第二人民医院介入血管外科，云南曲靖655000[摘要]目的探讨药物涂层球囊扩张术在下肢动脉硬化闭塞（arteriosclerosis obliterans, ASO）患者中的应用价值。

方法回顾性分析2020年1月—2022年9月在云南省曲靖市第二人民医院分别进行药物涂层球囊扩张术和支架置入术治疗的68例ASO患者的临床资料，按照手术方式的不同分为球囊组（41例，药物涂层球囊扩张术）和支架组（27例，支架置入术）。

比较两组患者手术前后踝肱指数（ankle brachial index, ABI）、跛行距离、血管狭窄程度，术后1年目标血管再狭窄率、不良事件发生率。

结果术后，两组ABI、跛行距离、血管狭窄程度均显著优于术前，差异有统计学意义（P<0.05）。

术后6个月，球囊组ABI、跛行距离显著高于支架组，差异有统计学意义（P<0.05）。

术后1年，球囊组血管狭窄程度显著低于支架组，差异有统计学意义（P<0.05）。

术后1年，球囊组患者再狭窄率（9.76% vs 44.44%）及不良事件总发生率（7.32% vs 37.04%）均显著低于支架组，差异有统计学意义（χ2=10.887、9.299，P<0.05）。

结论在ASO患者中，药物涂层球囊扩张术与支架置入术的近期疗效相当，远期疗效药物涂层球囊扩张术优于支架置入术，临床可依据患者具体情况建议更适合的手术方案。

[关键词]下肢动脉硬化闭塞症；支架置入术；药物涂层球囊扩张术；再狭窄[中图分类号]R4 [文献标识码]A [文章编号]2096-1782（2023）11(b)-0009-04Exploring the Application Value of Drug-coated Balloon Dilatation in Pa⁃tients with Lower Extremity Arteriosclerosis ObliteransWANG Maosheng, WANG Wei, REN Hong, HUANG Liqiong, YAN MingpengDepartment of Interventional Vascular Surgery, Qujing Second People's Hospital, Qujing, Yunnan Province, 655000 China[Abstract] Objective To explore the application value of drug-coated balloon dilatation in patients with lower extrem⁃ity arteriosclerosis obliterans (ASO). Methods The clinical data of 68 ASO patients who underwent drug-coated bal⁃loon dilatation and stent placement respectively in the Second People's Hospital of Qujing City, Yunnan Province, from January 2020 to September 2022 were retrospectively analyzed and divided into the balloon group (41 cases, drug-coated balloon dilatation) and the stent group (27 cases, stent placement) according to the difference of the surgi⁃cal methods. The ankle brachial index (ABI), claudication distance, degree of stenosis, restenosis rate of the target ves⁃sel at 1 year after the surgery, and the incidence of adverse events were compared between the two groups before and after the surgery. Results After the surgery, ABI, claudication distance, and stenosis degree in both groups were sig⁃nificantly better than before the surgery, and the difference was statistically significant (P<0.05). At 6 months after sur⁃gery, ABI and claudication distance in the balloon group were significantly better than those in the stent group, and the difference was statistically significant (P<0.05). At 1 year after surgery, the degree of stenosis in the balloon group was significantly lower than that in the stent group, and the difference was statistically significant (P<0.05). At 1 year after the surgery, the restenosis rate (9.76% vs 44.44%) and the total incidence rate of adverse events (7.32% vs [作者简介] 王茂生（1981-），男，硕士，副主任医师，研究方向为外周血管疾病的微创治疗。

放射医学专业英语翻译

Unit 4 Section ADNA Strand Breaks and Chromosomal Abberations Inducedby Ionizing Radiation（1）1.What is the principal target for the biologic effects of radiation on the basis of strong circumstantial evidence?基于详细的证据，辐射生物效应的主要靶点是什么？2. What is the structure of a deoxyribonucleic acid molecule?脱氧核糖核酸分子的结构是什么?DNA Strand BreaksDNA链断裂There is strong circumstantial evidence to indicate that deoxyribonucleic acid (DNA) is the principal target for the biologic effects of radiation, including cell killing mutation, and carcinogenesis. A consideration of the biologic effects of radiation therefore must begin logically with a description of the breaks in DNA caused by charged-particle tracks and by the chemical species produced.有足够多且详细的证据表明脱氧核糖核酸是辐射生物效应的主要的靶，包括细胞杀伤性突变和致癌作用。

因此，从带电粒子和化学产物导致的DNA链断裂来考虑辐射生物效应是较合乎逻辑的。

全身运动不安运动阶段质量评估对婴幼儿神经系统疾病预测价值的Meta分析

全身运动不安运动阶段质量评估对婴幼儿神经系统疾病预测价值的Meta分析门光国;王凤敏;崔英波【摘要】目的探讨婴幼儿早期(出生后20周内)全身运动(GMs)不安运动阶段质量评估对婴幼儿神经系统疾病的预测价值.方法利用数据库检索到2015年12月前发表的相关文献,共有16篇文献纳入研究并进行Meta分析.结果 16篇文献QUADAS评分≥10的有8篇,临床特征等信息差异均无统计学意义(P＞0.05).GMs 不安运动阶段质量评估对神经系统发育不良结局(包括脑性瘫痪)的预测分析显示,灵敏度、特异度、阳性似然比(PLR)、阴性似然比(NLR)和诊断比值比(DOR)分别为0.78、0.93、11.26、0.24和55.43;SROC曲线表明灵敏度和特异度最佳结合点的Q值为0.852 2,AUC值为0.919 0.GMs不安运动阶段质量评估对脑性瘫痪的预测分析显示,灵敏度、特异度、PLR、NLR和DOR分别为0.91、0.94、12.91、0.12和133.66,SROC曲线表明灵敏度和特异度最佳结合点的Q值为0.918 5,AUC值为0.969 2.结论 GMs不安运动阶段质量评估是预测婴幼儿神经系统疾病的一种有效方法,但不推荐单独使用.【期刊名称】《浙江医学》【年(卷),期】2016(038)014【总页数】5页(P1161-1165)【关键词】全身运动;不安运动阶段;婴幼儿;神经系统疾病;脑性瘫痪;Meta分析【作者】门光国;王凤敏;崔英波【作者单位】315012 宁波市妇女儿童医院新生儿科;315012 宁波市妇女儿童医院新生儿科;315012 宁波市妇女儿童医院新生儿科【正文语种】中文全身运动（general movements，GMs）是一种复杂的动作，包括头部、躯干、手臂和腿的运动，出现于胎儿早期并持续到出生后3～4个月。

近年来，GMs质量评估对婴幼儿脑性瘫痪（CP）等神经系统疾病的预测价值得到越来越多证据支持[1-2]。