Percutaneous transhepatic biliary drainage for obstructive jaundice caused by metastatic gastric
恶性梗阻性黄疸患者内支架置入术联合靶向性动脉灌注化疗栓塞的疗效观察及分析

(Department oflnterventional Treatment,Af iliated Hospital ofHebei University,Baodiing 071000,China) Abstract:Objective To investigate the ef icacy of percutaneous transhepatic biliary tract stent implantation
biliru bin and alkaline phosphatase level,the interval time before the obstruction recu ̄ed,survival time in two treatm ent groups were statistically analysed.Results No signif icant differences could be found for the change
w ith or w ithout transcatheter arterial chemoemblization in the treatment of advanced m alignant biliary
obstructive jaundice.M ethods The clinical data of 1 05 cases with advanced malignant biliary obstructive jaundice in my hospital from December 2006 to December 20 1 0 were retrospectively analyzed.Control group (n=45cases)was treated with percutaneous transhepatic biliary tract stent implantation alone,while experimental gr0up(,z=60cases)was treated with the combination of percutaneous transhepatic biliary tract stent implantation and subsequent transcatheter arterial chemoemblization.The time ofjaundice disappearance,the change of total
PTCD在老年恶性梗阻性黄疸ERCP操作失败患者中的疗效观察

PTCD在老年恶性梗阻性黄疸ERCP操作失败患者中的疗效观察刘献民【摘要】目的探讨老年恶性梗阻性黄疸(MOJ)患者ERCP操作失败后行PTCD补救治疗的临床疗效.方法选取53例ERCP操作失败后行PTCD治疗的老年MOJ患者作为研究组,并选取同期46例首选PTCD治疗的老年MOJ患者作为对照组,回顾性分析两组治疗前后临床症状和肝功能变化情况,手术成功率,术后并发症发生率及病死率等.结果研究组ERCP操作失败的主要原因为肿瘤致胆管严重狭窄,导丝无法通过,占67.9%;失败后行PTCD补救治疗,手术成功率为94.3%,与对照组比较无统计学差异(χ2=0.135, P=0.714);并发症发生率为30.0%,虽略高于对照组(24.4%),但差异并无统计学意义(χ2=0.368,P=0.544).由于肿瘤侵犯较重,研究组胆道支架置入成功率明显低于对照组(35.8% vs 69.6%,χ 2=11.208,P=0.001),但术后2周,研究组临床症状及肝功能各项指标均较术前明显改善(P<0.01).两组减黄效果相当,均无死亡病例.结论老年MOJ患者 ERCP操作失败后行PTCD补救治疗,其手术成功率、并发症发生率及病死率均与首选PTCD治疗无差异,临床疗效显著,值得临床参考.%Objective To explore the clinical effect of PTCD remedial therapy after ERCP failure in elderly patients with malignant obstructive jaundice (MOJ). Methods A total of 53 elderly patients with MOJ who initiated PTCD treatment after ERCP failure were selected (research group), and 46 elderly patients with MOJ who preferred PTCD treatment in the same period were selected (control group). Clinical symptoms and liver function changes, surgical success rate, incidence of postoperative complications and mortality rate between two groups were retrospectively analyzed. ResultsIn research group, the main reason for ERCP failure was tumor caused severe stenosis of the bile duct (accounted for 67.9%), which could not be passed by the guide wire. PTCD was performed after ERCP failure, the operation success rate was 94.3%, with no statistical difference compared with control group (χ2=0.135, P=0.714). The complication rate in rese arch group was 30.0%, slightly higher than that in control group (24.4%)(χ2=0.368, P=0.544). Due to tumor invasion, the success rate of biliary stent implantation in research group was significantly lower than that in control group(35.8% vs 69.6%, χ2=11.208, P=0.001).After two weeks, clinical symptoms and liver function indicators in research group were significantly better than those before operation (P<0.01). Two groups had the same effects of reducing jaundice. No deaths was found. Conclusion After ERCP failure in elderly patients with MOJ, PTCD remedial treatment is put in effect, and the success rate, complication rate and mortality are not different from the preferred PTCD treatment. This operation is worthy of clinical reference.【期刊名称】《肝胆胰外科杂志》【年(卷),期】2018(030)003【总页数】5页(P207-210,216)【关键词】黄疸,阻塞性;胰胆管造影,内镜逆行;经皮肝穿刺胆道引流术【作者】刘献民【作者单位】河南科技大学第一附属医院消化内科,河南洛阳 471003【正文语种】中文【中图分类】R657.4恶性梗阻性黄疽(malignant obstructive jaundice,MOJ)是一组临床上常见,且病死率较高的疾病,包括胆管癌、胆囊癌,肝癌、胰腺癌、壶腹癌及其他转移癌等,肿瘤浸润或淋巴结转移压迫胆道导致梗阻性黄疸。
ptcd术 PPT

PTCD护理
什么是PTCD术?
PTCD经皮经肝胆管引流
[percutaneous,transhepatic biliary(cholanic) drainage,PTBD或PTCD]是继经皮经肝胆管造影(PTC) 后发展起来的一种非外科手术引流术。主要是指经皮肝穿 刺途径置放胆道引流导管,达到胆道引流的作用、胆道梗 阻的减黄治疗。
你需要去医院了!!!
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出院宣教
保持引流管处伤口敷料干燥、清洁,伤口纱布脱落应及时来门诊更换。每 15 天门诊复查1次 ,嘱病人一旦黄疸复发、皮肤瘙痒、体温升高及时来院检查
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出院宣教
1.应教会病人及家属护理引流管, 2.出现引流管梗阻应及时到医院来解决; 3.无异常情况者,要求2个月~3个月更换引流管, 4.保持伤口敷料干燥、清洁。 5.切忌洗浴时污染引流口,最好擦浴。
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并发症的观察与处理
电解质紊乱
-观察病人胆汁引流量,定期抽血检查电解质,及时调整补 液。
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并发症的观察与处理
电解质紊乱
--处理: 若引流液达1500ml以上,可造成严重水电解质失衡,对此 类病人应记录出入量,以指导补液。
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出院宣教
避免过度活动 或提重物 翻身或移动时, 请勿压迫到导管
如何护理
(完整版)肝胆外科文献常用英语单词

文献生词malignancy 恶性,恶性肿瘤hepatectomy 肝切除术bilirubin 胆红素bilirubinemia 胆红素血症Hyperbilirubinemia 高胆红素血症Indocyanine green 吲哚花青绿indocyanine green retention 靛青绿滞留量试验hepatic insufficiency 肝功能不全,肝功能衰退jaundice 黄疸retrospective review 回顾性调查intraoperative 手术中的,术中parameters 参数Logistic Regression Logistic回归prognosis 预后prognostic 预后的hilar 门的,脐的cholangiocarcinoma 胆管上皮癌intrahepatic cholangiocarcinoma 肝内胆管癌anatomic 解剖的,解剖学的hepatic hilus 肝门perioperative 围手术期的indication 适应证,指征curative 治愈的resection 切除术likelihood 可能性liver function 肝功能metastasis 转移hepatocellular carcinoma 肝细胞癌unexpected 意外的,忽然的cholestasis 胆汁淤积biliary drainage 胆汁引流extended hemihepatectomy 扩大半肝切除术Trisegmentectomy 三段切除Chronic viral hepatitis 慢性病毒性肝炎cirrhosis 肝硬化serum 免疫血清,血清on admission 入院时,住医院时percutaneous 经皮的transhepatic 经肝的endoscopic biliary drainage 内镜胆管引流,内镜胆管引流术, endoscopic 内窥镜的;内窥镜检查的drainage tube 引流管,排液管portal vein 门(静)脉embolization 栓塞,栓塞术,栓子形成peritoneal 腹膜的dissemination 播散,散布laparotomy 剖腹手术distant metastasis 远端转移Surgical Procedures 外科手术anastomosis 吻合术enteric 肠的in terms of 以…的观点;以…的方式hemorrhage 出血hemorrhagic 出血性的hemolysis 溶血hemolytic 溶血的hematology 血液学hematological 血液的hemodynamics 血流动力学coagulation status 高凝状态prothrombin time 凝血酶原时间activated partial thromboplastin time 激活部分促凝血酶原激酶时间antithrombin 抗凝血酶thrombolytic 溶血栓药,血栓溶解剂duration 持续时间;期间nonlinear least squares method 非线性最小平方法natural logarithm 自然对数categorize 分类galactose tolerance test 半乳糖耐量试验half life 半衰期computed tomography scan 计算机体层摄影扫描,CT扫描contrast medium 对比剂,造影剂bolus 推注integrated software 集成软件variables 变量continuous variable 连续变量categorical variable 分类变量univariate 单变量multivariate 多变量univariate analysis 单变量分析multivariate analysis 多元分析,多元统计分析stepwise procedure 逐步过程chi square test χ2检验,卡方检验,cutoff value 截断值Odds Ratio 比值比Mann Whitney test 曼-怀二氏检验tailed 有…尾的receiver operating characteristic curve 接受者(机)操作特征曲线morbidity and mortality 并发症和死亡率decompression 减压in regard to 关于,至于living related liver transplantation 活体亲属供肝肝移植术parenchyma 实质liver parenchyma 肝实质excretory 排泄的,分泌的parenchymal 质的,主质的shrinkage 皱缩,皱缩度biotransformation 生物转化adenosine triphosphate 三磷腺苷ammonia 氨Aspartate Aminotransferase 天冬氨酸氨基转移酶Alanine Aminotransferase 丙氨酸氨基转移酶Lactate Dehydrogenase 乳酸脱氢酶alkaline phosphatase 碱性磷酸酶glutamyl 谷氨酰基Inferior Vena Cava 下腔静脉abdominal aorta 腹主动脉Paraaortic 主动脉旁的celiac axis 腹腔干common hepatic artery 肝总动脉proper hepatic artery 肝固有动脉superior mesenteric Artery 肠系膜上动脉Hepatic artery thrombosis 肝动脉血栓形成pseudoaneurysm 假性动脉瘤portacaval shunt 门(静脉与)腔静脉分流术arterialization 动脉化angiography 血管造影术occlusion 闭塞梗塞occluded 闭塞的collateral 侧的,侧支,副的confluence 合流,汇流autologous vein graft 自体静脉移植物porta hepatis 肝门Portal lymph node 肝门淋巴结second order biliary radicles 二级胆管根lobar atrophy 肝叶萎缩caudate lobe 尾状叶falciform ligament 肝镰状韧带periampullary 壶腹周围的Retroduodenal 十二指肠后的jejunum (jejunal) 空肠(的)ileum (ileal) 回肠(的)colon(colonic) 结肠(的)rectum (rectal) 直肠(的)anal canal 肛管oncology 肿瘤学oncological 肿瘤学的neoplasm 肿瘤,新生物neoplastic 肿瘤的,新生物的neoplastic seeding 肿瘤播种papillary tumor 乳头瘤adenocarcinoma 腺癌cystadenoma 囊腺瘤testis 睾丸gastrinoma 胃泌素瘤squamous cell carcinoma 鳞状细胞癌carcinoid tumors 类癌sarcoma 肉瘤focal nodular hyperplasia (FNH) 局灶性结节性增生parenchymal disease 器质性疾病advanced cancer 晚期癌症well differentiated 分化良好nodule 结节nodal metastases 淋巴结转移therapeutic effect 疗效neoadjuvant chemotherapy 新辅助化疗radiofrequency ablation 射频消蚀arterial chemoembolization 动脉化疗性栓塞infiltrating 浸润macroscopically 肉眼[检查]的;目视的carcinoembryonic antigen 癌胚抗原indication 适应症指征contraindication 禁忌证preoperative workup 术前全面评估postoperative morbidity rate 术后并发症发生率operative approach 手术入路radical operation 根治术,根治性手术en bloc 整个地,整块地inoperable 不能手术的,不能做手术的palliative 姑息的diagnostic laparoscopy 诊断性腹腔镜检查non-therapeutic laparotomy 非治疗性剖腹探查术invasive techniques 微创技术procedural complications 手术并发症pancreaticoduodenectomy 胰十二指肠切除术Adrenalectomy 肾上腺切除术thrombectomy 血栓摘除术lymphadenectomy 淋巴结切除术Lymph Node Dissection 淋巴结清扫术lymph node harvest 淋巴结清扫end to side anastomosis 端侧吻合术hepaticojejunostomy 肝空肠吻合术cholecystectomy 胆囊切除术Caudate lobectomy 尾状叶切除术radiopharmaceutical agent 放射性药剂iodized oil 碘化油absolute ethanol 无水乙醇scintigraphy 闪烁扫描术helical 螺旋的,螺旋状,螺旋状的cross sectional imaging 横断层面成像magnetic resonance imaging (MRI) 磁共振成像endoscopy retrograde cholangiopancreatography (ERCP)内镜下逆行胆胰管造影magnetic resonance cholangiopancreatography (MRCP)磁共振胰胆管成像intraoperative ultrasonography 术中超声检查法contrast enhanced computed tomography对比增强扫描CTpositron emission tomography PET正电子发射断层扫描cholangiogram 胆管造影Recurrence 复发follow up 随访concomitant 伴发的,附随的comorbidities 并存病bleeding 出血,流血extravasation 外渗,溢出hemobilia 胆道出血biliary fistula 胆瘘pleural effusion 胸腔积液lung edema 肺水肿splenomegaly 脾肿大hypersplenism 脾功能亢进hepatic encephalopathy 肝性脑病ascites 腹水subphrenic abscess 膈下脓肿endotoxaemia 内毒素血症myocardial infarction 心肌梗死pyrexial 发热的hypothermic 低体温的Biliary Stricture 胆管狭窄steatohepatitis 脂肪性肝炎fatty liver 脂肪肝adipose tissue 脂肪组织primary sclerosing cholangitis 原发性硬化性胆管炎angina 心绞痛sepsis 败血症,脓毒症perfusion 灌注ex vivo 离体,在活体外in situ 原位right upper quadrant 右上象限proximal part 近心端perineural 神经周围的bifurcation 二根分叉部,分岔ipsilateral 身体的同侧的,同侧的Institutional Review Board 机构审查委员会Ethics Committees 伦理学委员会predispose to 易患,使易感染、诱发platelet 血小板hyperalimentation 高营养支持cirrhotic 硬变的morbidity 并发症,发病率medications 用药dislodge 移去,逐出,取出gonadal 性腺的,生殖腺的Histologic 组织学的frozen section 冰冻切片atrophy 萎缩hypertrophy 肥大,过度生长proliferation 增生,增殖hyperplasia 增生;数量性肥大Stem cells 干细胞bone marrow derived 骨髓衍生的epithelium 上皮,上皮细胞encased 包裹reconstruction 重建,再造,重构inflammatory 炎症性的broad spectrum antibiotics 广谱抗菌素blood culture 血培养Gram Negative bacillus 革兰阴性[芽胞]杆菌cut surface 切面stent 支架catheter 导管direct cannulation 直接插管spectrophotometer 分光光度计rupture 破裂,vt.(使)破裂somatostatin 生长抑素Extracellular Matrix 细胞外基质cohort 同期组群Length of Stay 住院时间after discharge 出院后stratified 分层的,成层的clear cut 明确的In this regard 在这方面come at a cost 是有代价的progressively 进行性地,渐进地rationale 原理,基础理论homogeneous 同类的同质的heterogeneous 异类的,不同的putative 假定的omnipotent 全能的,无所不能的as controls 作为对照preconditioned 预处理preconditioning 预处理prospectively 前瞻性prospective randomized date 前瞻性随机数据Disease-Specific survival 疾病特异性生存率irreversible 不可逆的references 参考Cochrane 循证医学cholangiopancreatography 胰胆管造影术resolution 分辨率(决心,决议解决)herein 如此,鉴于,在此处iatrogenic 医源性palliation 缓和,减轻running suture 连续缝合orthotopic liver transplantation 原位肝移植chemoradiation 放化疗preneoplastic change 癌前变化carcinogenesis 致癌作用dysplasia 发育不良,不典型增生endoprosthesis 内镜置管术pruritus 瘙痒pruritis 瘙痒症Etiology (aetiology) 病原学etiologic 病原学的epidemiology 流行病学epidemiological 流行病学的pathophysiology 病理生理学lesion 病变Radionuclide 放射性核素nitrosamine 亚硝胺类pathogenesis 发病机制carcinoid 类癌Mucinous Adenocarcinoma 粘液腺癌Clear cell adenocarcinoma 透明细胞腺癌Signet ring cell adenocarcinoma 印戒细胞腺癌Adenosquamous Carcinoma 腺鳞状癌Squamous Cell Carcinoma 鳞状细胞癌Oat Cell Carcinoma 燕麦细胞癌Undifferentiated Carcinoma 未分化癌Papillomatosis 乳头状瘤病Papillary Carcinoma 乳头状癌hepatoblastoma 肝母细胞瘤Haemangioendothelioma 血管内皮瘤neuroendocrine tumour 神经内分泌瘤Leiomyosarcoma 平滑肌肉瘤malignant fibrous histiocytoma 恶化纤维组织细胞瘤nodular tumors 结节性肿瘤cachexia 恶液质sterilize 灭菌,消毒surgical radicality 手术的根治性angiogenetic 血管生成angiogenic 血管源性的,生成血管的antiangiogenic 抗血管生成的chemosensitization 化疗增敏photosensitizer 感光剂,光敏剂irradiation 放射,照射conformational radiotherapy 适形放射治疗brachytherapy 短距离放射治疗stereotactic 立体定位的,立体定向的interventional radiology 介入放射学oxaliplatin 奥沙利铂doxorubicin 多柔比星gemcitabine 吉西他滨immunosuppressant 免疫抑制剂Portography 门静脉造影术contrast agent 对比剂,造影剂lipiodol 碘油Iodophor 碘伏cystic duct 胆囊管choledochal duct 胆总管choledochal cysts 胆总管囊肿Choledocholithiasis 胆总管结石hepatolithiasis 肝内胆管结石病oriental cholangiohepatitis 东方人胆管肝炎Biliary malformation 胆管畸形Liver fluke 肝吸虫protocol 治疗方案therapeutic regimen 治疗方案Palliative Treatment 姑息治疗Signs and Symptoms 体征和症状plethora 多血症,多血质Differential Diagnosis 鉴别诊断Randomized Controlled Trials 随机对照试验enterocinesia 肠动,肠蠕动Ligation 结扎术luminal obstruction 官腔阻塞screening 普检,筛查,筛选predisposing factor 易感因素enhanced susceptibility 增强易感性hyperbaric oxygen treatment 高压氧治疗asymptomatic 无症状的indolent 无痛的Intractable Pain 顽固性疼痛visceral 内脏的steatosis 脂肪变性latency 潜伏期side effects 副作用decompensation 失代偿anoxia 缺养症anoxic 缺氧的anoxemia. 缺氧血症;血缺氧ischemia 局部缺血,缺血Ischemia-Reperfusion Injury 缺血再灌注损伤ischemic change 缺血性改变anemia 贫血pyogenic 化脓的purulent 化脓性,脓性的hepatomegaly 肝肿大umbilical fissure 裂脐cytokine 细胞因子neuropeptide 神经肽neurotransmitter 神经递质fluorescence in situ hybridization 荧光原位杂交necrosis 坏死necrocytosis 细胞坏死apoptosis 凋亡apoptotic 细胞凋亡的desmoplastic reaction 纤维成形性反应oncogene 癌基因Suppressor Genes 抑制基因genetic 遗传的epigenetic change 基因外改变hypermethylation 超甲基化sequential occurrence 顺序发生stepwise 分步的,分段的,逐步的mesenchymal 间质morphology 形态atypia 非典型,异型性Phenotype 表型dehydration 脱水paraffin 石蜡impregnation 浸渍,受精,受孕embedding 包埋,埋植serial section 连续切片anesthesia 麻醉anesthesiology 麻醉学anesthetist 麻醉师palpation 触诊orifice 管口,口,小孔one orifice 一个管口intubate 插管pancreatic secretion 胰腋centrifuge 离心,,离心机cannulation 管子reactive oxygen species 活性氧recanalization 再通,再穿通Celiac Plexus 腹腔丛arteriolar 微动脉的,小动脉的Collateral Circulation 侧支循环intima 内膜subintimal 内膜下的mitochondria 线粒体multifocal 多病灶的endemic 地方性的amenable 适合的more specifically 更具体地说mainstay 主要依据kink 扭折,纽结lethal 致命的peculiarity 特性armamentarium 医疗设备,设备demarcate 划界线,分开,区别paucity 资料贫乏migration 移位interim report 中期报告nihilistic 虚无主义的enigmatic 难理解的,神秘的occult 隐匿的,潜隐的autopsy 尸检detritus 腐屑,腐质,碎屑antegrade 顺行的retrograde逆行的endogenous 内源的,内生的exogenous 外源的,外生的intracorporeal 体内的extracorporeal 体外的autocrine 自分泌paracrine 旁分泌xenogenic 异体的,异种的cryptogenic 隐原性的,原因不明的insidiously 隐袭地congenital 先天的,天生的hereditary 遗传的,遗传性的pitfall 缺陷Biliary anomalies 胆道畸形cholecystolithiasis胆囊结石cholecystitis 胆囊炎choledocholithiasis 胆总管结石total bilirubin总胆红素unconjugated bilirubin 游离胆红素conjugated bilirubin 结合胆红素bile plug 胆栓sinusoid 血窦,窦状隙sinusoidal 血窦的窦状隙的transjugular 经颈静脉的portosystemic shunt 门体分流术hepatic coma 肝昏迷hyperammonaemia 高氨血症hypoalbuminemia 低白蛋白血症neuropsychiatric 神经精神性的confusion 意识错乱,意识模糊disorientation 定向障碍astrocyte 星形胶质细胞inflammatory mediator 炎症介质neutrophil (neutrophilic granulocyte) 嗜中性粒细胞macrophage 巨噬细胞phagocyte 吞噬细胞phagocytosis 吞噬作用mitogen 促细胞分裂原,有丝分裂原reticuloendothelial system 网状内皮系统Synthase 合酶dysregulation 调节异常,失调chromosome 染色体nuclear atypia 核异型nucleotide 核苷酸mitochondria 线粒体mitochondrial 线粒体的microsome 微粒体microsomal 微粒体的detoxify 去毒, 解毒,戒烟毒detoxification 解毒(作用),脱毒,戒毒治疗carcinogen 致癌物mutagen 诱变剂,致突变原carbohydrate antigen 糖类抗原标志物,糖链抗原glycoprotein 糖蛋白extirpation 摘除malignant transformation 恶变,恶性转化forceps biopsy 钳夹活检,钳夹活检术transpapillary 经十二指肠乳头stenosis 狭窄stenotic 狭窄的patency rate 通畅率vasculature 脉管系统diffuse intravascular coagulation 弥散性血管内凝血(DIC) coagulant and fibrinolytic systems 凝血和纤溶系统circulatory disturbance 循环紊乱Vascular Permeability 血管通透性vasodilatation 血管扩张vasopressor 血管升压类药物vasopressin 加压素endothelin 内皮缩血管肽prostaglandin 前列腺素Saphenous Veins 隐静脉renin 肾素angiotensin 血管紧张素aldosterone 醛固酮oestrogen (estrin) 雌激素progestogen (progestin) 孕激素androgen (androtin) 雄激素testosterone 睾酮acute tubular necrosis 急性肾小管坏死oedema 水肿oliguria 少尿症diuretic(a) 利尿剂haemofiltration 血液滤过dialyse 透析dialysate (Dialysis Solutions) 透析液acute respiratory distress syndrome 急性呼吸窘迫综合征(ARDS) diaphragm 横隔dyspnea 呼吸困难pulmonary oedema 肺水肿ventilatory dysfunction 通气功能障碍Total Parenteral Nutrition 全胃肠外营养enteral nutrition 肠道营养malabsorption 吸收不良venoplasty 血管成形术hematoma 血肿perforation 穿孔paracentesis 穿刺,穿刺术granulomatous inflammation 肉芽肿性炎症Bacterial Translocation 细菌移位the administration of antibiotics 抗生素的应用prophylactic antibiotics 预防性抗生素synbiotic therapy 合生元治疗free radical 自由基lactate 乳酸盐malaise 不适感,全身乏力episode 发作idiopathic 特发性的,自发性的tracer 示踪剂relaparotomy 再手术mild to moderate 轻度到中度multifactorial 多因子的,多因素的iohexol 碘海醇procaine 普鲁卡因lidocaine 利多卡因analgesia 镇痛dehiscence 裂开cryopreserved 冷藏保存的discriminant analysis 判别分析cadaveric 尸体的subjects 受试者obliteration 涂去,抹消,删除milieu 环境,境界potent 有力的,有效的schematic diagram 示意图,原理图misidentification 错误认同,错认algorithm 公式,算法,推导strong echo 强回声acoustic shadow 声影hyperecho(ic) 高回声(的)isoecho(ic) 等回声(的)hypoecho(ic) 低回声(的)anecho(ic) 无回声(的)aseptic technique 无菌术asepsis 灭菌antisepsis 消毒emergency operation 急诊手术confine operation 限期手术selective operation 择期手术evidence-based medicine 循证医学polymerase chain reaction (PCR) 聚合酶链反应inquiry 问诊chief complaints 主诉history collection 病史采集history of present illness 现病史past history 既往史personal history 个人史marital history 婚姻史menstrual history 月经史child bearing history 生育史family history 家族史physical examination 体格检查inspection 视诊palpation 触诊percussion 叩诊auscultation 听诊abdominal pain 腹痛abdominal distension 腹胀diarrhea 腹泻constipation 便秘nausea 恶心vomit 呕吐stool 大便urine 小便aspiration 误吸asphyxia (apnea) 窒息atelectasis 肺不张arrhythmia 心律失常cardiac arrest 心脏骤停ventricular fibrillation 心室纤颤hyperthermia 高热hypothermia 低温Natrium (sodium) 钠Kalium (potassium) 钾Chlorine 氯Calcium 钙Magnesium 镁Phosphorus 磷ion 离子homoeostasis 体内平衡derangement 紊乱isotonic dehydration 等渗性缺水hypotonic dehydration 低渗性缺水hypertonic dehydration 高渗性缺水water intoxication 水中毒hyponatremia 低钠血症hypernatremia 高钠血症hypochloremia 低氯血症hyperchloremia 高氯血症hypokalemia 低钾血症hyperkalemia 高钾血症hypocalcemia 低钙血症hypercalcemia 高钙血症hypomagnesemia 低镁血症hypermagnesemia 高镁血症hypophosphatemia 低磷血症hyperphosphatemia 高磷血症metabolic acidosis 代谢性酸中毒metabolic alkalosis 代谢性碱中毒respiratory acidosis 呼吸性酸中毒respiratory alkalosis 呼吸性碱中毒hematocrit (Hct) 血细胞比容autologous blood transfusion 自体输血salvaged autotransfusion 回收式自体输血predeposited autotransfusion 预存式自体输血hemodiluted autotransfusion 稀释式自体输血cryoprecipitate 冷沉淀furuncle 疖furunculosis 疖病carbuncle 痈acute lymphangitis 急性淋巴管炎erysipelas 丹毒abscess 脓肿dermoid cancer 皮肤癌melanotic 黑痣melanoma 黑色素瘤lipoma 脂肪瘤neurinoma 神经鞘瘤neurofibroma 神经纤维瘤capillary hemangioma 毛细血管瘤angiocavernoma 海绵状血管瘤racemosum hemangioma 蔓状血管瘤sebum cyst 皮脂腺囊肿tetanus 破伤风gangrene 坏疽superinfection 二重感染septicemia 败血症debridement 清创术simple goiter 单纯性甲状腺肿hyperthyroidism 甲亢hypothyroidism 甲减mastitis 乳腺炎mastopathy 乳腺病,乳腺增生症mastectomy 乳房切除术teratoma 畸胎瘤inguinal hernia 腹股沟疝femoral hernia 股疝incisional hernia 切口疝umbilial hernia 脐疝hernia of linea alba 白线疝interloop abscess 肠间脓肿helicobacter pylory (HP) 幽门螺杆菌pyloric obstruction 幽门梗阻vagotomy 迷走神经切断术lymphoma 淋巴瘤duodenal diverticulum 十二指肠憩室intussusception 肠套叠polyps 息肉ulcerative colitis 溃疡性结肠炎rectal prolapse 直肠脱垂anorectal abscess 直肠肛管周围脓肿anal fistula 肛瘘anal fissure 肛裂haemorrhoids 痔internal haemorrhoids 内痔external haemorrhoids 外痔mixed haemorrhoids 混合痔annulus haemorrhoids 环形痔proctocolectomy 直肠与结肠切除术major operation 大手术omentum 网膜pancreaticobiliary 胰胆管的Bile canaliculus 胆小管mediastinum 纵隔quadrate lobe 方叶organic 有机的,器官的interferon 干扰素glomerular filtration rate 肾小球滤过率Fulminant Liver Failure 暴发性肝衰竭Nephrotic Syndrome 肾病综合征enteropathy 肠病,肠病变Esophageal cancer 食管癌gastroesophageal varices 胃食管静脉曲张Supine Position 仰卧位informed consent 知情同意sequelae 后遗症,转归demarcate 划界线,分开,区别postprandial 食后的to date 迄今为止regarding 关于serologic 血清学的Serology 血清学hepaplastin test 肝促凝血活酶试验urea 尿素heme 血红素anionic 阴离子的。
优选ptcd术

拔管的护理
拔管指征: ❧生命体征平稳 ❧胆汁引流量达700 ml以上 ❧大便颜色转黄 ❧黄疸消退 ❧血胆红素下降
ptcd术
什么是PTCD术?
PTCD经皮经肝胆管引流
[percutaneous,transhepatic biliary(cholanic) drainage,PTBD或PTCD]是继经皮经肝胆管造影(PTC) 后发展起来的一种非外科手术引流术。主要是指经皮肝穿 刺途径置放胆道引流导管,达到胆道引流的作用、胆道梗 阻的减黄治疗。
并发症的观察与处理
胆道出血
--处理:
绝对卧床休息,观察血压、脉搏、呼吸、面色及意识状态 变化情况.观察胆汁引漉的颜色,量、性质的变化。遵医 嘱静脉输注止血药物,用0.9钠注射液100 mL加入去甲 肾上腺索8 mg行低压胆道每日2次.并夹管保留10 min ,3 d后出血逐渐停止。
生(出血、感染、瘘等);水电解质、酸碱平衡
记录:引流量或24小时出入量 体位:半卧位
引流是关键
正常每日胆汁引流量约500ml~800ml 引流液逐渐减少的可能情况:
量减少,颜色变金黄色,浑浊减轻 好转,可能局部炎症控制,胆道狭窄改善、胆管部分或 完全通畅。
量骤减或停止,并发右上腹疼痛、发热 排除引流管受积压、扭曲(可用少量生理盐水冲管后回 抽若回抽物为胆汁,一般为引流管开口紧贴胆管壁,调整 引流管位置即可。若回抽物为混浊液或黄白色脓液,及时 汇报医生,进行抗炎治疗。 颜色:正常胆汁棕黄色,感染性胆汁呈墨绿色,胆道内出血 胆汁呈血性暗红色。
胆系急症(急诊医学)

胆系急症1.急诊常见胆系急症包括急性胆囊炎(cholecystitis)及急性胆管炎(cholangitis)。
2.急性胆囊炎指胆囊的突发炎症,在胆囊炎症的发展过程中,胆囊管梗阻是主要因素。
3.急性梗阻性化脓性胆管炎是急性胆管炎的严重类型,是由于胆管梗阻和细菌感染,胆管内压升高,肝脏胆血屏障受损,大量细菌和毒素进入血液循环,造成以肝胆系统病损为主,合并多器官损害的全身严重感染性疾病,需及时处理,以挽救生命。
4.接诊后应立即检查生命体征,并予吸氧、连接心电监护、建静脉通路、测微量血糖。
5.梗阻原因结石>蛔虫>狭窄,多见于胆总管下段;致病菌以大肠埃希菌感染最常见。
6.Charcot三联症腹痛、寒战高热、黄疸;出现休克及精神神经症状为Reynolds五联症。
7.注意与胃肠穿孔、肝脓肿、急性胰腺炎、肾盂肾炎等鉴别,以及心肌梗死、酮症酸中毒等引起腹痛相鉴别。
8.床边B超是最常用的简便、快捷、无创性辅助诊断方法,急性胆囊炎可显示胆囊增大、壁厚、胆囊周围渗液及结石影;急性梗阻性化脓性胆管炎显示肝内胆管、胆总管扩张及胆道结石等征象。
9.如能转运,尽快行腹部CT、MRCP等检查。
10.尽快完成血常规、凝血四项、肝肾功能、淀粉酶、血生化、心肌酶及心电图等辅助检查。
11.积极抗感染、抗休克治疗,针对致病菌使用敏感、足量抗生素。
12.手术原则是解除梗阻,胆道减压,保持引流通畅,力求简单快速。
病历摘要男性,69岁,主因“右上腹痛伴发热5小时”来急诊。
患者5小时前进食油腻食物后突然出现右上腹持续性剧烈绞痛,向右肩部放射,伴恶心呕吐2次,呕吐物为胃内容物及黄色苦味液体。
既往有胆系结石病史。
查体:T 39.5℃,P 105次/分,R 30次/分,BP 100/60mmHg,SpO2 94%。
痛苦面容,巩膜黄染,心肺听诊无异常。
腹部平坦,肝浊音界无缩小,右上腹压痛、反跳痛、肌紧张,Murphy征(+)。
肠鸣音正常。
患者指尖血糖8.2mmol/L,心电图示窦性心动过速。
仑伐替尼联合信迪利单抗二线治疗肝内胆管癌的效果和安全性

!6?@A!仑伐替尼联合信迪利单抗二线治疗肝内胆管癌的效果和安全性丁晓燕,孙 巍,申燕军,滕 颖,许雅文,李文东,陈京龙北京地坛医院肿瘤内科,北京100015摘要:目的 初步探索仑伐替尼联合信迪利单抗在肝内胆管癌二线治疗中的疗效和安全性。
方法 回顾性分析北京地坛医院医院2019年10月31日—2021年10月31日收治的无法手术根治的肝内胆管癌二线治疗患者的临床资料,患者使用仑伐替尼联合信迪利单抗治疗。
随访患者,采用RECIST1.1标准评价疗效。
主要观察终点为至疾病进展时间(TTP),次要观察终点为肿瘤客观缓解率(ORR)、疾病控制率(DCR)、总生存期(OS)和安全性。
Kaplan-Meier法绘制生存曲线,组间差异采用log-rank检验。
结果 共27例患者入组,其中男15例(55.6%),女12例(44.4%),中位年龄58岁(33~73岁)。
患者中位TTP为5.5个月(95%CI:1 7~9.3),13例(48.1%)患者因疾病死亡,中位OS为11.2个月(95%CI:5.0~17.4)。
总体ORR为40.7%,DCR为70.3%。
66 7%发生了不同程度的不良事件。
ALT和AST升高分别为44.4%,高血压37.0%,胆红素升高为29.6%,腹泻29.6%;尿蛋白、食欲下降和乏力分别为25.9%。
无治疗相关的死亡;仅有1例发生IV度免疫相关性肝脏毒性,经激素治疗后缓解,无后遗症,导致信迪利单抗永久性停药。
合并淋巴结转移的患者中位TTP与无淋巴结转移患者比较显著缩短(4.5个月vs18.8个月,P=0.035),获得疾病缓解的患者,中位TTP显著延长[11.6个月(95%CI:5.6~17.6)vs2.8个月(95%CI:1.8~3.8),P<0.001];合并淋巴结转移的患者中位OS有缩短趋势[9.6个月(7.9~11.3)vs21.9个月(95%CI:0~44.9),P=0.053],疾病获得缓解的患者中位OS显著延长[16.6个月(95%CI:9.0~24.2)vs6.9个月(95%CI:3.6~10.2),P=0.011]。
ERCP与PTCD治疗恶性梗阻性黄疸的疗效与安全性对比的Meta分析

ERCP与PTCD治疗恶性梗阻性黄疸的疗效与安全性对比的Meta分析张睿;武希润;丁鹏【期刊名称】《胃肠病学和肝病学杂志》【年(卷),期】2023(32)2【摘要】目的系统评价经皮经肝穿刺胆道引流术(percutaneous transhepatic cholangial drainage, PTCD)与内镜下逆行性胰胆管造影(endoscopic retrograde cholangiopancreatography, ERCP)两种引流方式对恶性梗阻性黄疸(malignant obstructive jaundice, MOJ)的临床疗效和手术安全性。
方法通过机算机检索CNKI、VIP、CBM、万方、Cochrane、PubMed等数据库,收集国内外关于使用PTCD与ERCP对MOJ进行治疗的相关文献。
应用RevMan 5.4.1进行数据分析。
对比两种引流方法在手术的成功率、黄疸的缓解率、临床疗效、手术前和手术后相关肝功能指标变化(包括ALT、AST、TBIL、DBIL)以及手术后并发症的发生率。
结果共纳入15篇相关文献,共有病例数1 235例。
Meta分析结果显示:两者的手术成功率差异无统计学意义(P=0.02);低位梗阻患者在行ERCP后黄疸缓解率较高(P=0.006)、临床疗效更好(P=0.0005),高位梗阻患者在行PTCD后黄疸缓解率较高(P<0.0001)、临床疗效更好(P<0.0001),总体的黄疸缓解率和临床疗效在进行这两种引流方法后的数据差异无统计学意义(P=0.16、0.08);两组的手术前和手术后的ALT下降值、AST下降值、TBIL下降值、DBIL下降值对比和术后的并发症发生率情况对比,差异无统计学意义(P>0.05)。
结论通过使用ERCP或PTCD这两种介入手段均可以有效缓解胆道梗阻并改善肝功能。
低位梗阻患者行ERCP临床疗效更优,高位梗阻患者行PTCD临床疗效更优。
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Percutaneous transhepatic biliary drainage for obstructive ja u nd ice ca used by metastatic gastric CanCer:efficacy and comp¨CatIonsI i i … ‘ ■
Wenchang Yu,Kongzhi Zhang,Shiguang Chen,Mingzhi Hao Department of Interventional Radiology,Fujian Provincial Cancer Hospital,Fuzhou 350014,China Received:3 December 2010/Revised:20 December 2010/Accepted:25 January 2011 @Huazhong University of Science and Technology and Springer・Verlag Berlin Heidelberg 201 1
Abstract Objective:The aim of our study was lo evaluate lhe efficacy and incidence of complications of percutaneous transhepatic biliary drainage(PTBD1 as palliative lreatmenl of obstructive iaundice caused by metastatic gastric cancer. Methods:Hospital records were reviewed for 32 consecutive patients with biliary obstruction caused by metastatic gastric cancer who underwenl PTBD al our institution between October 2004 and April 201 0.Patients(23 males and 9 females)age ranged fr0m 35 lo 72 years.The indexes of hepatic function before PTBD and within one month after PTBD were compared. The incidence of complications and corresponding lreatments were also documented.Results The Ievel of obstruction was defined as Ihe distaI bile ducl(beyond lhe JeveI of lhe liver hilum)in 22 patients(group 1)and fhe liver hilum in 1 0 patients (group 2).SuccessfuI decompression of lhe biliary system after PTBD was defined by a lotaf bilirubin decrease of more lhan 30%0f fhe baseline value.Success rates were 1 00%(22/22)for group 1,70%(7门0)f0r group 2,and 90.6%(29/32)for all patients.Differences in success rates between group 1 and group 2 were significant(P=0.024).Serum TBIL,ALT,and AST significantlydecreasedfrom(292.8±179.9)pmol/L,(174.5±107.4)IUIL,(159.9±103.9)IU/Lbefore PTBDlo(111.5±92.5) pmol/L。f58.5±46.3)fU/L,(59.6±48.9)IU/L,respectively within one month after PTBD(P<0.O5).Complications associ- ated with PTBD included cholangitis in 1 3 patients(40.5%),drainage lube displacement in 6 patients(1 8.8%),hemobilia in 4 patients(12.5%),lube occlusion jn 2 patients(6.3%),and pancreatitis in 1 patienc(3.1%).AIl complications were successfully lreated with appropriate measures.Conclusio,, Hepatic function can be improved by PTBD withoul serious complications in patients with obstructive jaundice caused by metastatic gastric cancer.
Key words gastric cancer;obstructive jaundice;percutaneous transhepatic biliary drainage
Biliarg obstruction as a result of metastatic carcinoma can originate from various kinds of tumors,such as car— cinoma of the colon,stomach,breast,lung,and cervix. Among these tumor types,gastric carcinoma 1s a more frequent cause of biliary obstruction.Bile duct obstruc— tion can be caused at the liver hilum level by lymphade— nopathy in the hepatoduodenal ligament and/or by liver metastases compressing hilar structures.It can also occur at the distal bile duct level(beyond the level of the liver hilum)due to lymphadenopathy in the abdominal cavity trom primary or recurrent gastric cancer after gastrec— tomy At the time of diagnosis,the majority of gastric can— cer patients with obstruction jaundice have a very poor prognosis[ , .Effective biliary decompression is urgent for improving hepatic function of the patients,as it allows Correspondence fo Wenchang Yu.Email:yuwenchang1818@yahoo.com.ca addition of subsequent anti 。tumor therapy to their treat 。 ment regimen.Percutaneous transhepatic biliary drain— age fPTBD)is a well—established interventional proce— dure widely used in patients with malignant obstructive iaundice[4, .Many studies have reported a role for PTBD in relieving obstructive jaundice resulting from miscel— laneous tumors as well as relative complications arising from PTBD in a number of patients[ , .However.specific reports on efficacy and complications of PTBD for ob— structive jaundice caused only by metastatic gastric can— cer are limited in the literature|8j_In the present study, we report on 32 metastatic gastric cancer patients with obstructive janndice who underwent PTBD procedures at our institute from October 2004 to April 2010.The change in hepatic function within one month after PTBD and complications associated with PTBD are presented. We discuss possible causes for these complications and summarize the corresponding treatment measures.