自组装单分子薄膜宋仕永

– A. Majumdar, Univ. of Cal. at Berkeley
Potential Risks of Nanotechnology
• Health issues
– Nanoparticles could be inhaled, swallowed, absorbed through skin, or deliberately injected – Could they trigger inflammation and weaken the immune system? Could they interfere with regulatory mechanisms of enzymes and proteins?
• Lab on chips help detection and diagnosis of diseases more efficiently • Nanowire and cantilever lab on chips help in early detection of cancer biomarkers
−To develop cure for traditionally incurable diseases (e.g. cancer) through the utilization of nanotechnology −To provide more effective cure with fewer side effects by means of targeted drug delivery systems
博士论文工作
博士论文工作
自组装有机薄膜的内在结构与摩擦学性能
• 含酰胺键自组装单分子薄膜 I
O H3C
16
①
N H Si(OCH2CH3)3
②
O H N H N O H N O H N O H N O
TPOA ① 预水解48h ② 环己烷稀释，沉积24h
O Si O O Si O
O
Si O
O
Si O
Nanotechnology in Health Care
Thermal ablation of cancer cells
− Nanoshells have metallic outer layer and silica core − Selectively attracted to cancer shells either through a phenomena called enhanced permeation retention or due to some molecules coated on the shells − The nanoshells are heated with an external energy source killing the cancer cells
胞的发育能力随剂量和暴露时间增加而降低
• 量子点（QDs）会诱导普遍的酰基化反应，致使细胞内DNA
结构出现紊乱，并在一定程度上破坏线粒体的功能。
• 碳纳米材料（碳纳米管，富勒烯）：体内无法
清除的长碳纳米管诱发小鼠体内吞噬细胞融合的细胞因子，导致肉芽 瘤的生成；富勒烯则会诱发脂质过氧化以及细胞膜结构的破坏，使产 生细胞毒性。
自组装单分子薄膜
Terminal group
Alkyl or derivatized alkyl group
Interchain vander Waals and other interactions
Surface-active head group
Chemisorption at the surface
Treatment • Targeted drug delivery
− Nanoparticles containing drugs are coated with targeting agents (e.g. conjugated antibodies) − The nanoparticles circulate through the blood vessels and reach the target cells − Drugs are released directly into the targeted cells
SY Song et al Applied Surface Science 2011,257,10254.
pH敏感聚合物胶束
Nanomedicine
Nanomedicine is the application of nanotechnology in medicine, including to cure diseases and repair damaged tissues such as bone, muscle, and nerve Key Goals for Nanomedicine
化工材料系列讲座
自组装单分子薄膜
Self-Assembled Monolayers
宋仕永 2012.11.15
前言
• 纳米材料的表面或界面（Surface & Interface） 决定着材料的宏观性质。有人把物质的表面 层称做是物质的第四种状态 。
• 人们通过控制和改变固体表面化学组成获得 具有特定性能的材料。
O
Si O
O
silicon wafer
SY Song et al Langmuir 2006,22, 6010-6015.
• 含酰胺键自组装单分子薄膜 II
O O Si N H H N O H N N H O
结 构 示 意 图
O Si
N H N H
O Si
H2N
Cl O
+
10 O H2N HN HN
Targeted drug delivery – Targeted drug delivery using a multicomponent nanoparticle containing therapeutic as well as biological surface modifying agents – Mauro Ferrari, Univ. of Cal. Berkley
10 O HN
10 O
制 备 过 程
H2N NH
H2N
1
Acetone/H2O, 1 h
NH
NH
NH
2
NH
NH
NH
Cyclohexane, Et3N , 24 h
H3CO
Si
OCH3
OCH3
+
Si OH O
OH
OH
O
Si O O
Si O
Si O
O
Si O O
Si O
SY Song, et al The Journal of Physical Chemistry C, 2008, 112, 3805-3810.
在河南大学的科研
• 仿关节软骨结构水凝胶薄膜
聚合物刷
水凝胶
表面引发原子转移自由基聚合
• POMA聚合物薄膜
10
10
NH2 NH2 NH2 NH2
*
*
n THF 333K silicon DA SAMs silicon
* O O * O NH2 N O NH2 NH2
n
O
+
POMA聚合物膜在氨基自组装膜表面的形成示意图。
The microfluidic channel with nanowire sensor can detect the presence of altered genes associated with cancer – J. Heath, Cali. Insti. of
Technology
The nanoscale cantilever detects the presence and concentration of various molecular expressions of a cancer cell
自组装单分子薄膜为研究表面现象提供了一个理 想的模型，如边界润滑、生物传递、表面能的控制等， 它还在摩擦学、材料学、电子学、非线性光学等诸多 领域有重要的应用基础研究价值。
SAMs的种类
• 长链酸类自组装单层膜
O O
O O O
O O
O
O
O O
O O
O O
O
Al2O3
AgO
图 3 Al2O3及AgO表面上长链羧酸单层膜的结构示意图
DA膜和DAC18膜的衰减全反射红外光谱。
SY Song et al Langmuir, 2008, 24, 105-109.
新加坡国立大学博后工作
Single-Molecule Force and Fluorescence Lab
R. Liu et al Biophysical Journal 96(9), 3810-3821 (2009)
SAMs在分子电子学中应用
SAMs在生物学中应用
常用仪器
• 扫描探针显微镜（SPM）
原子力显微镜AFM
云母的原子STM图
常用仪器
椭圆偏光测厚仪
常用仪器
• 衰减全反射红外光谱 • 反射红外光谱
常用仪器
• X光电子能谱（XPS）
XPS ，全称为X-ray Photoelectron Spectroscopy，是一种基于光电效应的电 子能谱，它是利用X射线光子激发出物质表面原子的内层电子，通过对这 些电子进行能量分析而获得的一种能谱。
•含酰胺键自组装单分子薄膜 III
疏水性，承载能力 降低摩擦系数
O
N H
O
N H
O
N H