millipore纯水机介绍
MERCK MILLIPORE默克密理博Aquelix5实验室纯水机
MERCK MILLIPORE 默克密理博Aquelix 5实验室纯水机MERCK MILLIPORE 默克密理博Aquelix5实验室纯水机是一款专为中小型实验室量身定制的实验室高纯水制备系统，系统采用Millipore专利的Elix电流去离子技术，结合优良的预处理和先进的反渗透技术，以便捷、经济的方式生产高品质的二级高纯水。
Millipore密理博Aquelix5实验室纯水机以自来水为进水直接生产高纯水，产水适用于微生物、光谱、色谱等多种实验需求。
○ 针对中小型实验室用水量小，并对水质有一定要求的客户○ 解决中小型实验室获取高纯水难的问题 (蒸馏水器不安全且维护繁琐、运行费用高，桶装水水质较差且无法在线监控)○ 面对空间有限的实验室，只需A3纸大小的面积，即可安装○ 维护简单：Aquelix整套系统只有一套耗材，更换简单，只需30秒钟即可完成○ 运行、维护费用低高品质纯水，源自卓越的Elix技术MERCK MILLIPORE 默克密理博Aquelix5实验室纯水机所采用专利的Elix抗结垢连续电流去离子技术，与您目前正在使用的其它纯化方法(蒸馏、国产反渗透/去离子系统、瓶装水)相比，具有更多优势：品质无忧Elix 技术确保持续稳定地生产出高品质纯水优化流程：取水口处可选择安装Millipak®0.22μm终端过滤器，有效去除微生物清晰完整的系统参数显示(水质、报警/提示)运行成本低Elix技术提供持续的离子交换树脂再生，无需更换耗电量低：系统用电仅为传统蒸馏装置的1/180进水耗水量低：仅为蒸馏装置的1/5使用便捷根据需求，最高2升/分钟的流速进行纯水取用耗材更换简单快速，仅需花费几十秒钟维护少：Elix 技术无需强酸强碱或复杂的除垢处理。
* MERCK MILLIPORE 默克密理博Aquelix5实验室纯水机设计用于生产符合欧洲、日本和美国药典要求的纯水(Millipak终端过滤器用来满足微生物指标)。
merck millipore 默克密理博纯水超纯水一体系统明澈D24UV操作手册
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明澈-D 24 UV
需要的物品
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物品检查清单 安装开始前请核实所有物品是否可用。
o 纯水系统主机 (A) o 用户手册和快速参考指南 (B) o 外部电源 (C) o PROGARD®预处理柱和 Q-GARD®超纯水柱（D） o 储水水箱：30、60 或 100 升（E） o POU 取水器（F） o 包含下述的附件包： 管材 配件 电源
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2 显示器和小键盘
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3 Progard® 预处理柱位置
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4 锁定手柄
11ห้องสมุดไป่ตู้
5 消毒/清洁口
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6 电源接口
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7 系统进出水口连接
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*系统断电时，应将电源与插座断开。
说明 系统 ID 和序列号 电源适配器* Q-GARD®超纯水柱位置 超纯水进出口接口 POU（用水点）取水POU 取水开关取水器终端过滤器
重要提示！
应在干净且干燥的地方安装并操作您的纯水系统。请参考本手册最 后部分的环境要求。
您的纯水系统不适于家庭使用。
纯水系统长时间断电会使计时器的电池放电，导致失去时间和日期记录。如果长 时间关闭纯水系统，应使用实验室关闭模式请与您的服务代表联系。
经常保存系统的历史记录-每三个月或每半年。参见 Millitrack 文档。
软件选项millitrack软件是通过ajax异步javascript和xml技术开发的一种嵌入式gui图形用户界面软件它能运用tcpip以太网协议通过点到点计算机或直接通过网络连接生成交互式网页
用户手册
明澈™-D 24UV 纯水系统
序言
感谢您购买我们的纯水系统。 对于任何疑问或请求，请根据以下联系信息与 Merck Millipore 联系。
默克密理博纯水机的优点
默克密理博纯水机的优点密理博（millipore）公司作为生命科学领域的策略性供应商，为生物科学讨论和生物制药工业供应技术、工具和服务。
2023年4月21日，密理博中国正式对外发布新品—Milli-QIntegral纯水/超纯水一体化系统。
该款纯水系统可以直接以自来水进水，只需经过一台主机，即可得到水质稳定的II级纯水和I级超纯水。
Milli-QIntegral系统结合了Elix、Milli-Q纯水系统的技术和解决方案，生产出带压力的纯水和超纯水，用户可以直接掌握整个水纯化链的水质。
除此之外，应用了可以通过微弱电流不断再生离子交换树脂的Elix技术，胜利降低了Milli-QIntegral超纯水系统的维护和运营成本。
Milli-QIntegral系统可以依据用户的不同需要，每天产纯水或超纯水60~300L不等。
配有两种分体式取水器：Q-POD（取超纯水）和E-POD （取纯水），从点滴取水至2L/min，产水速度可任意调整且操作简便。
用户可以根据不同水质要求选择不同的终端精制器，特地去除热源、核酸酶、细菌、颗粒和有机物。
依据用户的不同需求，密理博纯水机每天可生产60至300升纯洁水或超纯水。
配备两个分体式取水器：取超纯水和取纯水，滴水量取至2L/min，出水速度可任意调整，操作简便。
用户可以依据不同的水质要求选择不同的终端精炼机，以特地去除热源，核酸酶，细菌，颗粒和有机物，分体式取水器使用起来特别便利。
它不仅适用于试验室中的全部玻璃器皿，还供应自动和手动进水方式，系统操作和水质信息（离子和有机污染）显示在主机和饮水机底座的LCD屏幕上，可以在线查看或在线打印。
密理博纯水机结构紧凑，与系统配套的取水器占地面积小，可以安装在试验室的任何地方，例如工作台下方或墙上。
由于它供应了多种敏捷的安装方法和升级选项，因此可以在不同阶段依据用户的试验需求来更改配置。
每个主机可以连接3个取水器，这些取水器可以放置在试验室的不同位置。
MilliporeSigma Milli-Q CLX 7000系列连接水纯化系统用户说明书
®7000 SeriesRobust & Reliable Performancefor Maximum Lab ProductivityYour biomedical laboratory is a busy and demanding environment, with clinical analyzers capable of processing several thousand samples per day. As water is the most frequently used fluidic reagent onboard an analyzer, your choice of water purification system is key to smooth and uninterrupted daily lab operations.The water purification solution must reliably provide your clinical analyzer(s) with consistent water quality that meets CLRW standards of the CLSI®. With the high-throughput Milli-Q® CLX 7000 analyzer feed series, your clinical laboratory benefits from a high-performance and economical water purification solution that fulfills its many critical needs:3Simply log into the MyMilli-Q™ web interface todiscover MyMilli-Q™ Remote Care , our online service and monitoring capability designed to support you in maximizing uptime. This unique service gives you and our support teams access to your Milli-Q ® CLX 7000 system and its data, for quick and precise remote diagnostics as well as repairs. Learn more about thisnew service capability on pages 8 and 9 of this brochure. And because every lab situation is different, our Milli-Q ® Services offering can be customized around your needs:• Before installation, a certified Field Service Engineer will analyze your feed water quality to provide the optimal parameter configuration for your system. This maximizes the performance and reliability of your Milli-Q ® CLX 7000 instrument and associated clinical analyzers.• Choose the Milli-Q ® Service Plan that’s right for your lab—from a single annual Preventive Maintenance Visit with replacement of aging parts, to full system coverage. • Online Contract Management lets you moreefficiently track your water system’s service history and easily schedule maintenance visits.• A range of options lets you customize your service solution. Choices include qualification, calibration and verification services, scheduled consumables shipments, and sanitization.Best-in-class Milli-Q ®Services,now supported by MyMilli-Q™ Remote CareBecause the reliability of biomedical laboratories is critical to patients and doctors alike, we offer an unprecedented level of service with the Milli-Q ® CLX 7000 Series.Trust in Pure Experience & ExpertiseWe are a partner you can count on. As one of the top three R&D investors in the Life Science Toolsindustry, we have a long history of strong partnerships with both biomedical laboratories and major clinical analyzer manufacturers. This valuable experience has enabled us to develop our expertise concerning end-user applications, such as biology, biochemistry, microbiology and immunology, and to design top-quality water purification solutions dedicated to feeding clinical analyzers.The Milli-Q ® CLX 7000 Series is manufactured in an ISO ® 9001- and ISO ® 14001-registered site. Additionally, to ensure efficiency and safety ofoperation, systems are CE-, cULus-, and FCC-certified. Furthermore, to reduce environmental impact, the Milli-Q ® CLX 7000 Series follows European Restriction of Hazardous Substances (RoHS) and Waste Electricaland Electronic Equipment (WEEE) directives.Contact your local Merck office for information about the service offer available for your facility, or visit /milli-qservices4® technology purification stepsElix ® module: Our unique technology is based on anion-permeable and cation-permeable membranes and high-quality, ion-exchange resin.Water produced by the Elix ® module enters the reservoir with resistivity greater than 5 MΩ·cm @ 25 °C (typically up to 15 MΩ·cm @ 25 °C).*The Milli-Q ® CLX 7000 Series relies on complementary water purification techniques, including state-of-the-art Elix ® electrodeionization (EDI) technology, to ensure production of consistently high quality water meets CLRW standards – at low and predictable running costs.In the Milli-Q ® CLX 7000 Series, potable tap water is first treated with a Progard ® pack and purified by reverse osmosis (RO) to remove up to 99% of contaminants. The resulting RO permeate water then enters the Elix ®Bacteria and their by-products interfere with chemistry assays and enzyme immunoassays, typically leading to unstable analyzer calibrations, high absorbance of blanks, reference drifts, and errors on mean patient values.In the Milli-Q ® CLX 7000 Series, UV lamp sanitization occurs at three stages:• During water production , a 254 nm bactericidal UV lamp inactivates bacteria.• In the tank , a UV lamp (ASM, Automatic Sanitization Module) regularly irradiates stored water and the tank walls, preventing bacterial growth and the formation of biofilm.* When CO dissolved in feed water is less than 30 ppm.5Optimize water consumption with an environmentally responsible system containing E.R.A.® technologyMilli-RX™ system(1992)Elix system (2003) with RO recovery loop Today’s Mili-Q CLX 7000Series system with E.R.A. technology10000m 900080007000600050004000300020001000WASTE (m )CLRW (m )Over the last 25 years, we have dramatically reduced water purification system water consumption, enabling laboratories to save up toseveral thousand dollars per year on tap water expenses . The graph shows water consumption and the split between CLRW produced and reject water for three of our water purification systems over a seven-year period (production of 1000 L/day of CLRW-quality water, 312 days per year).The Milli-Q ® CLX 7000 Series incorporates our E.R.A.® (Evolutive Reject Adjustment) technology — providing users with even greater savings.With its innovative and efficient reverse osmosis (RO) recovery loop, the Milli-Q ® CLX 7000 Series optimizes water consumption by recycling part of the waterrejected to the drain, thus reducing water waste and also extending RO cartridge and Progard ® pack lifetimes.Furthermore, depending on the feed water qualityanalysis, the Milli-Q ® CLX 7000 Series will calculate the best water recovery and will automatically optimize water consumption by means of motorized valves.No matter what the feed water temperature, inlet pressure, or conductivity may be, E.R.A.®technology’s automated valves ensure that the Milli-Q ® CLX 7000 Series flow rate and water recovery remain constant.* Users no longer need to manually adjust valves to maintain production flow rate and protect RO cartridge lifetime.These latest RO technologies illustrate our dedication to developing environmentally responsible waterpurification solutions to reduce tap water and system consumables use. The solutions reduce maintenance time, as well as the risk of human error — letting users save money on system operation, and also enjoy peace of mind with higher reliability, and optimized water purification system/analyzer uptime.* Please refer to Feed Water Requirements in the Specifications Table.6User-friendly system interface with all relevant information at a glanceWith its large, innovative touchscreen, the system is designed for intuitive operation, with all information available at a glance in a dashboard format. Nine different languages are available for greater convenience. Navigating and interacting with your water purification system has never been easier!... where a wizard will guide you through the maintenance procedure with easy, step-by-step instructions. You don’t need to be an expert to perform regular maintenance on your system!Clear, visible status of all consumables Notification zone for alerts and alarmsLarge display shows water qualities and storage volumeSystem status zone7An easy-to-use,low-maintenance systemA mobile, customizable systemLow maintenance saves time and increases profitability• Robust and patented Elix ® technology ensuresconsistent pure water, as well as low and predictable running costs – regardless of your feed water quality.* No maintenance is required for the Elix ® module.• An ergonomic and patented pack-locking system lets you change packs easily and quickly.• RFID technology prevents insertion of an incorrect purification cartridge in Milli-Q ® CLX 7000 systems, and also ensures automatic traceability of pack use and replacement, saving time for the user.• Automatic self-maintenance functions significantly reduce tap water use and increase cartridge lifetime: –The Progard ® pretreatment pack incorporatesseveral purification media in just one consumable to protect the RO membrane from particles, free chlorine, and scaling. Maintenance is easier and quicker with only one pack to change! –The system’s flush mode and cleaning cycles keep the RO membrane in top operating condition.Never before has it been so easy—or so time-saving—to use and maintain your water purificationsystem.Optimal use of lab spaceThe Milli-Q ® CLX 7000 Series is compact, quiet, and mounted on wheels with brakes, so it can be placed wherever it’s convenient — and moved to another location as the lab configuration grows or evolves.Customizable systems to fit your specific requirementsA number of options and accessories are available for the Milli-Q ® CLX 7000 Series to fit your specific requirements and to improve water quality monitoring:• An online TOC (Total OrganicCarbon) monitor allows verification that the TOC level of system water is below 500 ppb as required for CLRW quality. This avoids the need for duplicate assays or repeated analyzer calibrations. • Degassing option provides asolution for feed water that is highly contaminated with gases, such as a CO 2 concentration above 30 ppm.• RO regeneration tool , for use whenfeed water quality is poor, provides additional RO membrane cleaning, and completes the action of the Progard ® Autoclean pack.• Sanitary sampling valve for safe and reliable water sampling for microbiological analysis.• Water sensor(s) and alarm output(s) also can be easily added to your Milli-Q ®CLX 7000 system.* P lease refer to Feed Water Requirements in the Specifications Table.An ergonomic and patented pack-locking system.245 13 67What can MyMilli-Q™ Remote Care help you to achieve?• Assure productivity 24/7. Access real-time system information, water quality data and much more from anywhere at any time for 24/7 confidence in your lab’s performance.• Save time. In the event you need support, your interaction with Milli-Q® Services is streamlinedas MyMilli-Q™ Remote Care provides our service organization a secure and direct view of your system information. Our service teams can remotely diagnose and potentially repair your system, avoiding the need to wait for a service visit.• Maximize uptime. Receive notification of alertsand alarms (by email or SMS) allowing you to promptly and remotely manage your system, either independently or with our remote assistance.• Easier data traceability & accreditation. Audit preparation and lab accreditation have never been so effortless as data are automatically saved and can be easily accessed, searched and retrieved. Choose to download a standard Quality Report, or to create your own tailored reports.Connect to Peace of Mind Milli-Q® Services presents MyMilli-Q™ Remote Care, an onlineservice that simplifies the management of your Milli-Q® CLX7000 water purification system.1 Quickly view all system details.2E asily share water quality and system information with your analyzer supplier’sservice hotline.† CAP , College of American Pathologists9A water purification system that facilitates accreditation.Water used to feed an analyzer is a critical reagent. Its quality must be documented forbiomedical laboratories seeking accreditation (or reaccreditation) to the ISO 15189:2012 standard supported by CAP † 15189SM accreditation.To facilitate compliance with worldwide regulatory organization guidelines, Milli-Q ® CLX 7000 systems allow for full monitoring capabilities as well as automatic e-record archiving both:• Directly in the system — data are retrievable by USB key or via your lab’s intranet connection.• In the cloud when MyMilli-Q™ Remote Care is activated.E-record archiving supports traceability of all water-related daily operations, measurements and events. It saves time and is less expensive to manage versus paper documentation, as it removes the need for daily checks of the water purification system, hand-recording of parameters in a lab book, and physically archiving years of paper data.Now, with the user-friendly MyMilli-Q™ web interface and MyMilli-Q™ Remote Care service capability, data management is even moresimplified. Your system and water data are readily accessible and rapidly searchable, graphable and reportable — from anywhere at any time.An interactive Event Traceability tool lets you view events by type and over the timeline you specify. View past events (alarms, alerts, consumable replacements, service visits, custom events) and plan for future systemmaintenance. Click on any event and its details are displayed in the blue banner above the timeline. In this example, aProgard ® cartridge was replacedby J.SMITH on Aug 19, 2019.Water quality parameters (resistivity, temperature, TOC) are graphed over the timeline of your choice and can be easily downloaded.The system automatically stores a fully traceable—and easily retrievable—record of service history. In addition to archiving data, MyMilli-Q™ online tool lets you streamline contract management. You’ll be able to schedule maintenance visits, manage consumable deliveries and renew your service contracts, all online.Milli-Q® CLX 7000 Series Water Purification Process1. Inlet Valve2. Progard® Pretreatment Pack3. Conductivity Cell4. RO Pump5. Pressure Sensor6. RO Cartridge7. Twin Motorized Valve –RO Recirculation 8. RO Recirculation Loop9. Temperature Sensor10. Flow Sensor11. 3-Way AutomaticRinsing Valve12. Elix® Module13. Resistivity Cell14. UV Lamp (254 nm)15. Vent Filter16. Sanitary Overflow Sensor17. Automatic SanitizationModule (ASM)18. Distribution Pump19. Emergency Back Up –Quick Connector20. Q-Gard® Polishing Pack21. Opticap® Filter (0.22 μm)22. Sampling Valve23. Automatic Loop Rinsing Valve24. Back Pressure Regulator25. Recirculation Loop Valve26. TOC Monitor (Option)27. Degassing Unit (Option)Milli-Q® CLX 7000 Series SpecificationsThe Clinical Laboratory Reagent Water (CLRW) Quality Standard, defined by the CLSI®Resistivity> 10 MΩ.cm @ 25 °C Total organic carbon (TOC)< 500 ppbBacteria< 10 CFU/mL Filtration0.22 μmMilli-Q® CLX 7000 Series PerformanceMilli-Q® CLX 7040Milli-Q® CLX 7080Milli-Q® CLX 7120Milli-Q® CLX 7150 Make-up flow rate to reservoir*40 L/h (10.6 gal/h)80 L/h (21.1 gal/h)120 L/h (31.7 gal/h)150 L/h (39.6 gal/h) Make-up resistivity> 5 MΩ.cm @ 25 °C (10-15 MΩ.cm @ 25 °C typically)Built-in reservoir volume (net volume)90 L90 L140 L140 LDistribution flow rate to analyzers 4 L/minDistribution pressure to analyzers Adjustable: 0.9 up to 2.1 bar†Water Quality Distributed to AnalyzersResistivity> 15 MΩ.cm @ 25 °C Total organic carbon (TOC)Typically < 30 ppb Bacteria Typically < 1 CFU/mL Dissolved silica< 0.05 mg/L* Nominal flow rates ± 10% between 10 and 35 °C. Additional deviation of -3% per °C from 10 °C to 5 °C.† With a distribution loop length of 20 m.Technical Appendix10*Subject to subscription. Please contact your local Merck office for information about the service offer available for your facility.Dimensions and WeightsDimensions (H x W x D)1255 x 543 x 797 mm(49.4 x 21.4 x 31.4 in)1255 x 543 x 797 mm(49.4 x 21.4 x 31.4 in)1255 x 543 x 947 mm(49.4 x 21.4 x 37.3 in)1255 x 543 x 947 mm(49.4 x 21.4 x 37.3 in)Net weight (shipping box)134 kg (295.4 lb)143 kg (315.3 lb)155 kg (341.7 lb)167 kg (368.2 lb) Operating weight222 kg (489.4 lb)234 kg (515.9 lb)303 kg (668 lb)318 kg (701.1 lb)Feed Water RequirementsPressure 2 – 6 barFlow rate> 10 L/min at 2 barTap water connection¾ in. Gaz MFeed water type PotableTemperature 5 – 35 °CConductivity10 – 2000 μS/cm at 25 °C pH 4 – 10Total hardness (as CaCO3)< 300 ppmCO2< 30 ppmSilica< 30 ppmMerck KGaAFrankfurter Strasse 25064293 Darmstadt, Germany /labwater。
Millipore纯水系统操作及维护
产水电阻抗值小于1.0ＭΩ
系统需要经常运转才能工作在最佳 状态
可能原因
ⅰ Elix系统的使用频率过低 ⅱ Elix系统长时间停用
当系统长时间停止制水时,EDI失去能够 再生离子交换树脂的电流⇒离子交换纯 化能力降低
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①LOW PRESSURE ②PRODUCT ③%REJECTION
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①LOW PRESSURE ②PRODUCT ③%REJECTION
③「 %REJECTION 」
表示ＲＯ膜的去除率低于92.0％
原水
RO膜
Progard II 增压泵
电导计
RO膜去除率的確認：
OPERATE/STANDBY
MEASURE
CLEANING
MENU
EDI模块
Pres.：4.5 bar 50% Product ：3.8MΩ・cm
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(3)耗材使用期限
货号 PR0G00002 TANKMPK01
TANKMPK02
CDRC00201 CDRC60201 CDRC60202 ZLXUVLP01 ZWCL01F50 ZFRES00UV
名称 Progard Ⅱ柱 水箱通气过滤器(Elix水箱
用)
水箱通气过滤器(RiOs水箱 用)
反渗透膜(Elix3/RiOs5用) 反渗透膜(Elix5/RiOs8用) 反渗透膜(Elix10/RiOs16用) Elix UV灯 清洗药片 ASM紫外灯
系统在产水状态下,按MEASURE键数次
Pres. 4.5 bar 50% %Rejection 96.2%
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①LOW PRESSURE ②PRODUCT ③%REJECTION
Millipore超纯水制造系统操作及保养手册
範例: 針對共同項目
M ILLI-Q Ac. Gr. Bio.Syn.A10
: 所有線條皆為柱狀。 （表示本功能是用在所有四種機型）
針對特殊系統: Gradient 所有圖形皆收錄在手冊最後之摺頁內。
系統各部分圖形 - 詳列於手冊之後
如何使用本手冊
本手冊是說明如何安裝耗材，使用及保養您的Milli-Q純水系統，雖然Milli-Q系統非常容易使用，但還 是強烈建議使用者徹底閱讀本手冊，可防止系統故障，可使使用者更熟悉所有功能及操作指令。
如何區分不同 Milli-Q 機型所涵蓋之不同應用內容
本操作手冊使用下述表記來區分。
如何使用本手冊 ......................................................................................................................................... 4 如何區分不同機型所針對的應用內容...................................................................................................... 4 警告標誌之意義.......................................................................................................................................... 4 前言 ............................................................................................................................................................. 5 一般說明...................................................................................................................................................... 5 系統運作原理.............................................................................................................................................. 5 系統結構流程圖.......................................................................................................................................... 6 規範.............................................................................................................................................................. 7 裝置 ............................................................................................................................................................. 9 系統裝置...................................................................................................................................................... 9 裝置方法.................................................................................................................................................... 10 MILLI-Q 系統操作 .................................................................................................................................. 13 操作的幾種模式........................................................................................................................................ 13 標準顯示.................................................................................................................................................... 13 附加顯示.................................................................................................................................................... 14 按鍵使用方法............................................................................................................................................ 15 MILLI-Q 系統啟動 ..................................................................................................................................... 20 保養 ........................................................................................................................................................... 21 例行保養時間表........................................................................................................................................ 21 例行保養.................................................................................................................................................... 22 疑難排除 ................................................................................................................................................... 25 疑難排除、訊息........................................................................................................................................ 25 警告號碼表................................................................................................................................................ 27
密理博 ADVANTAGE A10 纯水机
2-1 MILLI-Q® 超纯水系统概述 .....................................................................................................................2 2-2 MILLI-Q 产水规格..................................................................................................................................4 2-3 系统流程图 ...........................................................................................................................................4 2-4 技术规格...............................................................................................................................................7
第 4 章 使用 MILLI-Q 系统 ...................................................................................43
millipore RiOs5纯水机和超纯水机价格
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millipore RiOs5纯水机和超纯水机价格
millipore RiOs5
纯水机标题：millipore RiOs5纯水机
RiOs 超纯水系统以稳定的流速产生 III 级实验室
用纯水系统直接使用自来水做进水，将辅助纯化技
术结合在一个紧凑的系统设计中，不仅操作方便、可
靠，还允许以低操作成本对产水水质进行全面控制。
密理博millipore RiOs 5水纯化系统实验室用水标
准说明RiOs 5反渗透系统商标名: RiOs 应用: 160
to 320 L per day 标称透过流速，L/h: 5 (±
15%) 进水要求: 自来水做进水标称弃水流速，L/h:
25 深度，cm (in): 31.5 (12.4) 运行重量，kg (lb):
15 (33) 高度，cm (in): 45.7 (18) 系统回收率 (%):
38 污染物截留率，有机物 (%): ≥99 宽度，cm
(in): 25.5 (10) 污染物截留率，离子 (%):
96–99 污染物截留率，颗粒 (%): ≥99 使
用的滤芯: Progard，RO 纯化柱污染物...
厂家：上海政泓
市场价格：
优惠价格：百度
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8
细菌
✓活的细胞并有生长繁殖能力 ✓直径0.27 µm 到3.0 µm
(病毒 0.04 µm 到0.1 µm) ✓水源,空气,人体都带菌 ✓细菌本身影响生物学实验 ✓裂解释放热原,酶等多种物质 ✓产生菌膜持续释放污染物 ✓堵塞仪器通道
Pseudomonas aeruginosa
6
有机物
✓干扰有机分析的背景 ✓微生物滋生的营养物质 ✓包住去离子用的树脂 ✓两类特殊有机物
热原、RNA酶
自然的和人造的
7
热原与RNA酶
✓热原也称为内毒素 革兰氏阴性菌细胞壁分泌多糖 刺激免疫系统产生发热 高压灭菌180度 4小时去除
✓RNA酶主要作用是裂解RNA RNA酶无处不在 对高温酸碱都有耐受性 可保持活性数周
电阻率 (MW.cm) 18.20 18.11 18.01 17.92 17.83 17.74 17.65 17.56 17.47 17.38
T/℃
26
为什么要检测TOC
TOC (ppb) / 电阻率 x10 (MW.cm) 400 350 300 250 200 150 100
50 0 0 15 30 45 60 75 90 105 120 135
32
LC-MS TIC profile of reagent water sources
% Intensity
Bottled HPLC-grade reagent water versus polished water
100
7.1E+4
90
Source A
Source B
80
Source C
Source D
Negative dip
Distilled Water
Milli-Q with UV Water System
Higher TOC Water Lower TOC Water
31
对基线的影响
TOC的大小直接影响到液相检测时的基线水平
Ultrapure water 20 ppb Ultrapure water 13 ppb Ultrapure water 9 ppb Ultrapure water 5 ppb Ultrapure water 2 ppb
20
建立一个水纯化链
预处理柱
自来 水
反渗透
预纯化单元 (RiOs)
➢ 各种纯化技术组合 ➢ 电阻率 18.2 MW.cm
➢ TOC < 5 ppb
水箱
离子交换树脂 + 活性碳
UV185/254nm
TOC 检测仪 TOC
精制单元
(Milli-Q)
电导率仪
超纯水
21
Resistivity, Mohm cm - TOC, ppb
反渗透水
UV185/254nm
TOC
30 25 20 TOC, ppb 15 10
5 0
1234567 # experiments
UV off UV on
19
人工合成活性碳： 去除TOC（有机物）
来源：高温裂解苯乙烯微球
孔径小，相对均一（ < 150 Å ） 表面积 : 1100 m2/g
对小分子量的有机物能够快速吸收 矿物离子溶出极低
纯水设备的水质监测
Polishing unit fed with reverse osmosis water
Cond/T (°C) detector
cond/temp electronics
control
20
electronics
Resistivity 15
water in
10
5 TOC
0
0
1000
P
P
进水
弃水
产水
12
离子交换树脂
固定阴离子 阳离子 聚苯乙烯骨架 交联剂 水
13
Ion-Exchange Resin Bead
SEM* of Ion-Exchange Resin Bead
* Scanning Electronic Microscopy
Bead diameter: 300 to 1200 µm
25°C 时，随着NaCl浓度的增加，Na+和Cl-的浓度都会增加，而H+和OH-的浓度
不变。电导率/电阻率会随之改变。
25
超纯水电阻率（R）随温度（T）的变化
R / MΩ ·cm
温度(°C)
24.0
24.1
24.2
24.3
24.4
24.5
24.6
24.7
90
24.8
80
24.9
70
60
25℃时，超纯水的电阻率等于
2000
3000
4000
5000
6000
7000
Volume, L
水温、水压 电阻率、TOC RO膜截留率
water out Sampling valve
UV lamp 185 + 254 nm lamp power
supply quartz Window
22
两个重要概念补充
➢ 电导率值与电阻率值 ----水中的离子含量
volume
Analysis Protocol
3 micron C18 column
Coulometric detector
Mobile phase: 0.05 M sodium phosphate / 0.05 M sodium acetate / 0.189 mM dodecyltrimethyl ammonium chloride / 3.66 mM tetractylammonium bromide; 30/70 methanol/water; pH 4.8
#1
1410
64
104
76
<10
#2
1180
38
75
55
<10
这些 TOC 值是用Ionics-Sievers TOC 分析仪测量的 (方法是酸处理 – 过硫酸，然后紫外光氧化）
29
TOC 监测
Solenoid Valve
Titanium Electrodes
Thermistor
Conductivity Purge
➢ 总有机碳值（TOC: total organic carbon） ----水中可氧化有机物含量
23
水的电导率值与电阻率值 （Conductivity & Resistivity）
F= Ci Zi ui
电导率 (Siemens/cm)
每种离子的浓度
迁移率
(moles/ml)
价位
V-1.cm2.s-1
Streptococcus p化碳
✓影响水的离子浓度和PH值 ✓直接参与反应 ✓影响水有效体积 ✓影响光学测定结果 ✓损耗仪器
10
纯化技术纯化效率
活性碳 微孔过滤 蒸馏 反渗透 离子交换 电去离子 紫外 超滤
2311BD10
11
反渗透
反渗透技术 (膜孔径为埃级 10-10m) 可以去除大部分的 杂质 (离子, 有机物, 颗粒物, 胶体, …)
实验室纯水系统的技术与发展
MILLIPORE简介
成立于1954年, 总部位于美国麻省 是一家以生物科学为主要目标市场的的高科技专业公司
第一家将精密膜过滤技术投入商业化应用，也是世界上第 一台实验室超纯水系统的制造商 其业务分三大块：实验室纯水、生命科学、生物制药
1973: Millipore 推出Milli-Q 超纯水系统，是世界上第一 个实验室标准水纯化系统。 1987: Millipore 在美国纽约证券交易所上市。
70
Source E
Source F
60
polisher H2O
water blank
System: PE BioSystems Mariner LC-MS Column: Phenomenex Luna C18 2.0 x 50 mm Solvent A = 98% H2O: 2% ACN: 0.1% formic acid Solvent B = 98% ACN: 2% H2O: 0.1% formic acid Gradient: Linear 0 -100% A to B 50 ml trace enrichment of sample Flow rate: 0.20 ml/min MS Detection: turbo ion spray at 300 C 2 second mass scans mass range 150 to 1000 Da
Lamp on Lamp off
Lamp on
30
对灵敏度的影响 维生素C的分析(Ascorbic Acid)
100 picomoles ascorbic acid in a 10 microliter injection
volume
50 picomoles ascorbic acid in a 10 microliter injection
Beads pores: 1 to 100 nm
Bead dry weight 40 to 60% T: -40 to + 40°C
14
Resin Bead Structure
Example: the cation-exchange model
Fixed Anion + Counter Cation
HH H-C-C-OH
HH
4
颗粒
✓阻塞过滤系统 ✓损坏泵系统 ✓吸附电荷影响离子浓度 ✓折射光线影响判读 ✓提供细菌滋生载体