Behavioral-level synthesis of heterogeneous BISR reconfigurable ASIC’s

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大鼠脑皮层中多巴胺受体的检定

大鼠脑皮层中多巴胺受体的检定

大鼠脑皮层中多巴胺受体的检定
邢成
【期刊名称】《中国应用生理学杂志》
【年(卷),期】1995(000)001
【摘要】本研究使用放射配基结合分析法,建立了对大鼠脑皮层多巴胺D1和D2型受体的检测方法。

测得正常大鼠脑皮层中D1受体的Bmax为103±53pmol/g蛋白,Kd值为3.2±1.2nmol/L;D2受体的Bmax为227±79pmol/g蛋白,Kd值为2.6±1.3nmol/L。

【总页数】1页(P87)
【作者】邢成
【作者单位】不详;不详
【正文语种】中文
【中图分类】R338
【相关文献】
1.大脑皮层发育不良鼠脑皮层和海马中的突触生长相关蛋白表达 [J], 马勋泰;冯占辉;吕洋;晏勇;
2.大脑皮层发育不良鼠脑皮层和海马中的突触生长相关蛋白表达 [J], 马勋泰;冯占辉;吕洋;晏勇
3.多巴胺受体在腹外侧眶皮层诱发抗伤害感受性效应中的作用 [J], 盛海燕;霍福权;屈超玲;杜剑青;唐敬师
4.氯氰菊酯对老年鼠脑皮层及血清中5-HT、DA、NE的影响 [J], 周礼华;陈韩磊;
刘函冰;韦钰;钱伟伟
5.miRNA-155在大鼠脑缺血/再灌注损伤早期大脑皮层组织中的表达及其意义 [J], 朱旭蓉;燕玉娥;狄政莉;王天仲;何芳;王新来;高晓宇;郑雪娇
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产低温脂肪酶菌株鉴定、发酵条件优化及酶学性质分析

产低温脂肪酶菌株鉴定、发酵条件优化及酶学性质分析

刘思远,申东晨,刘峥,等. 产低温脂肪酶菌株鉴定、发酵条件优化及酶学性质分析[J]. 食品工业科技,2023,44(20):116−125. doi:10.13386/j.issn1002-0306.2022120159LIU Siyuan, SHEN Dongchen, LIU Zheng, et al. Identification of A Cold-active Lipase Producing Strain, Optimization of Fermentation Conditions and Analysis of Enzymatic Properties[J]. Science and Technology of Food Industry, 2023, 44(20): 116−125. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022120159· 生物工程 ·产低温脂肪酶菌株鉴定、发酵条件优化及酶学性质分析刘思远,申东晨,刘 峥,鲁丽颖,徐 恒,董爱荣*(东北林业大学 林学院,黑龙江哈尔滨 150040)摘 要:为筛选高产低温脂肪酶的菌株,并对产酶条件进行优化,同时为脂肪酶的工业化开发提供生产资料。

从黑龙江省漠河县土壤样品中筛选出一株产低温脂肪酶菌株,通过形态学鉴定、生理生化实验及分子生物学鉴定,确定该菌株为普城沙雷氏菌(Serratia plymuthica )。

通过单因素实验,探究温度、pH 、装液量、接种量、碳源、氮源、金属离子、诱导剂等不同因素对菌株产酶的影响,通过Plackett-Burman 实验,爬坡试验及响应曲面设计,优化橄榄油、蛋白胨、装液量等因素的添加量。

结果表明:该菌株最优产酶条件为20 ℃、pH7.5、装液量42 mL 、接种量0.5%、20 g/L 麦芽糖、14 g/L 蛋白胨、0.5 g/L 的MgSO 4·7H 2O 及46 mL/L 橄榄油。

Hedgehog信号通路通过上皮细胞间质转分化调控乳腺癌细胞侵袭

Hedgehog信号通路通过上皮细胞间质转分化调控乳腺癌细胞侵袭

Hedgehog信号通路通过上皮细胞间质转分化调控乳腺癌细胞侵袭任徽;郭华;陈明伟;魏光兵;樊林;李徐奇【摘要】ABSTRACT:Objective To investigate the effect and mechanism of Hedgehog signaling pathway on the invasion of breast cancer cells in vitro.Methods The SHH,SMO and Gli-1 expression levels of breast cancer cell line MDA-231 and normal mammary epithelial cell line MCF-10A were detected by Western blot at protein level and by Real-time RT-PCR at mRNA level.Next,shRNA vector was transfected into the MDA-2 3 1 cells with highly expressed SMO,and the stable transfected cells were selected by G4 1 8 .Western blot and Real-time RT-PCR were performed to observe the inhibitory effect of RNAi on SMO expression.MTT assay was used to assess the influence of SMO siRNA on cell proliferation.Transwell assay was applied to observe cell invasion ability.The expressions of Gli-1,Snail,MMP-9,E-cadherin and Vimentin protein were determined by Westernblot.Results Compared with those of normal mammary epithelial cell line MCF-10A,the expressions of SHH,SMO and Gli-1 were significantly increased.The invasion of MDA-2 3 1 cells was inhibited significantly after SMO silencing.Additionally, the protein expressions of Gli-1 , Snail, MMP-9 and Vimentin were obviously inhibited, and E-cadherin was significantly increased.Conclusion Mutative activation of Hedgehog signaling pathway in breast cancer cells promotes cell invasion probably through induction of epithelial-mesenchymal transition of the tumor cells.%目的:研究Hedgehog信号通路对乳腺癌细胞侵袭能力的影响及其可能机制。

医学英语综合教程第三单元

医学英语综合教程第三单元

Unit3.Biochemistry and Human DevelopmentBiochemistry is the application of chemistry to the study of biological processes at the cellular and molecular level. It emerged as a distinct discipline around the beginning of the20th century when scientists combined chemistry, physiology and biology to investigate the chemistry of living systems. In a sense, biochemistry is both a life science and a chemical science. It uses the methods of chemistry, physics; molecular biology and immunology to study the structure and behavior of the complex molecules found in biological material andthe ways those molecules interact to form cells, tissues and whole organism. It covers a broad range of cellular functions from gene transcription to the structure and function of macromolecules.生物化学是在细胞和分子水平上运用化学技术研究生物过程的科学。

在20世纪初,当科学家联合化学,生理学和生物化学研究的生命系统时,开始出现这门独立学科。

遗传育种相关名词中英文对照

遗传育种相关名词中英文对照

遗传育种相关名词中英文对照中英文对照的分子育种相关名词3'untranslated region (3'UTR) 3'非翻译区5'untranslated region (5; UTR) 5'非翻译区A chromosome A 染色体AATAAA 多腺苷酸化信号aberration 崎变abiogenesis 非生源说accessory chromosome 副染色体accessory nucleus 副核accessory protein 辅助蛋白accident variance 偶然变异Ac-Ds system Ac-Ds 系统acentric chromosome 无着丝粒染色体acentric fragment 无着丝粒片段acentric ring 无着丝粒环achromatin 非染色质acquired character 获得性状acrocentric chromosome 近端着丝粒染色体acrosyndesis 端部联会activating transcription factor 转录激活因子activator 激活剂activator element 激活单元activator protein( AP)激活蛋白activator-dissociation system Ac-Ds 激活解离系统active chromatin 活性染色质active site 活性部位adaptation 适应adaptive peak 适应高峰adaptive surface 适应面addition 附加物addition haploid 附加单倍体addition line 附加系additive effect 加性效应additive gene 加性基因additive genetic variance 加性遗传方差additive recombination 插人重组additive resistance 累加抗性adenosine 腺昔adenosine diphosphate (ADP )腺昔二鱗酸adenosine triphosphate( ATP)腺昔三憐酸adjacent segregation 相邻分离A-form DNA A 型DNAakinetic chromosome 无着丝粒染色体akinetic fragment 无着丝粒片断alien addition monosomic 外源单体生物alien chromosome substitution 外源染色体代换alien species 外源种alien-addition cell hybrid 异源附加细胞杂种alkylating agent 焼化剂allele 等位基因allele center 等位基因中心allele linkage analysis 等位基因连锁分析allele specific oligonucleotide(ASO)等位基因特异的寡核苷酸allelic complement 等位(基因)互补allelic diversity 等位(基因)多样化allelic exclusion 等位基因排斥allelic inactivation 等位(基因)失活allelic interaction 等位(基因)相互作用allelic recombination 等位(基因)重组allelic replacement 等位(基因)置换allelic series 等位(基因)系列allelic variation 等位(基因)变异allelism 等位性allelotype 等位(基因)型allohaploid 异源单倍体allopatric speciation 异域种alloploidy 异源倍性allopolyhaploid 异源多倍单倍体allopolyploid 异源多倍体allosyndesis 异源联会allotetraploid 异源四倍体alloheteroploid 异源异倍体alternation of generation 世代交替alternative transcription 可变转录alternative transcription initiation 可变转录起始Alu repetitive sequence, Alu family Alu 重复序列,Alu 家族ambiguous codon 多义密码子ambisense genome 双义基因组ambisense RNA 双义RNAaminoacyl-tRNA binding site氨酰基tRNA接合位点aminoacyl-tRNA synthetase 氨酰基tRNA连接酶amixis 无融合amorph 无效等位基因amphipolyploid 双多倍体amplicon 扩增子amplification 扩增amplification primer 扩增引物analysis of variance 方差分析anaphase (分裂)后期anaphase bridge (分裂)后期桥anchor cell 锚状细胞androgamete 雄配子aneuhaploid 非整倍单倍体aneuploid 非整倍体animal genetics 动物遗传学annealing 复性antibody 抗体anticoding strand 反编码链anticodon 反密码子anticodon arm 反密码子臂anticodon loop 反密码子环antiparallel 反向平行antirepressor 抗阻抑物antisense RNA 反义RNAantisense strand 反义链apogamogony 无融合结实apogamy 无配子生殖apomixis 无融合生殖arm ratio (染色体)臂比artificial gene人工基因artificial selection 人工选择asexual hybridization 无性杂交asexual propagation 无性繁殖asexual reproduction 无性生殖assortative mating 选型交配asynapsis 不联会asynaptic gene 不联会基因atavism 返祖atelocentric chromosome 非端着丝粒染色体attached X chromosome 并连X 染色体attachment site 附着位点attenuation 衰减attenuator 衰减子autarchic gene 自效基因auto-alloploid 同源异源体autoallopolyploid 同源异源多倍体autobivalent 同源二阶染色体auto-diploid 同源二倍体;自体融合二倍体autodiploidization 同源二倍化autoduplication 自体复制autogenesis自然发生autogenomatic 同源染色体组autoheteroploidy 同源异倍性autonomous transposable element 自主转座单元autonomously replicating sequence(ARS)自主复制序列autoparthenogenesis 自发单性生殖autopolyhaploid 同源多倍单倍体autopolyploid 同源多倍体autoradiogram 放射自显影图autosyndetic pairing 同源配对autotetraploid 同源四倍体autozygote 同合子auxotroph 营养缺陷体B chromosome B 染色体B1,first backcross generation 回交第一代B2,second backcross generation 回交第二代back mutation 回复突变backcross 回交backcross hybrid 回交杂种backcross parent 回交亲本backcross ratio 回交比率background genotype 背景基因型bacterial artification chromosome( BAC )细菌人工染色体Bacterial genetics 细菌遗传学Bacteriophage 噬菌体balanced lethal 平衡致死balanced lethal gene 平衡致死基因balanced linkage 平衡连锁balanced load 平衡负荷balanced polymorphism 平衡多态现象balanced rearrangements 平衡重组balanced tertiary trisomic 平衡三级三体balanced translocation 平衡异位balancing selection 平衡选择band analysis 谱带分析banding pattern (染色体)带型basal transcription apparatus 基础转录装置base analog 碱基类似物base analogue 类減基base content 减基含量base exchange 碱基交换base pairing mistake 碱基配对错误base pairing rules 碱基配对法则base substitution 减基置换base transition 减基转换base transversion 减基颠换base-pair region 碱基配对区base-pair substitution 碱基配对替换basic number of chromosome 染色体基数behavioral genetics 行为遗传学behavioral isolation 行为隔离bidirectional replication 双向复制bimodal distribution 双峰分布binary fission 二分裂binding protein 结合蛋白binding site 结合部位binucleate phase 双核期biochemical genetics 生化遗传学biochemical mutant 生化突变体biochemical polymorphism 生化多态性bioethics 生物伦理学biogenesis 生源说bioinformatics 生物信息学biological diversity 生物多样性biometrical genetics 生物统计遗传学(简称生统遗传学) bisexual reproduction 两性生殖bisexuality 两性现象bivalent 二价体blending inheritance 混合遗传blot transfer apparatus 印迹转移装置blotting membrane 印迹膜bottle neck effect 瓶颈效应branch migration 分支迁移breed variety 品种breeding 育种,培育;繁殖,生育breeding by crossing 杂交育种法breeding by separation 分隔育种法breeding coefficient 繁殖率breeding habit 繁殖习性breeding migration 生殖回游,繁殖回游breeding period 生殖期breeding place 繁殖地breeding population 繁殖种群breeding potential繁殖能力,育种潜能breeding range 繁殖幅度breeding season 繁殖季节breeding size 繁殖个体数breeding system 繁殖系统breeding true 纯育breeding value 育种值broad heritability 广义遗传率bulk selection 集团选择C0,acentric 无着丝粒的Cl,monocentric 单着丝粒C2, dicentric双着丝粒的C3,tricentric 三着丝粒的candidate gene 候选基因candidate-gene approach 候选基因法Canpbenmodel坎贝尔模型carytype染色体组型,核型catabolite activator protein 分解活化蛋白catabolite repression 分解代谢产物阻遏catastrophism 灾变说cell clone 细胞克隆cell cycle 细胞周期cell determination 细胞决定cell division 细胞分裂cell division cycle gene(CDC gene) 细胞分裂周期基因ceU division lag细胞分裂延迟cell fate 细胞命运cell fusion 细胞融合cell genetics 细胞的遗传学cell hybridization 细胞杂交cell sorter细胞分类器cell strain 细胞株cell-cell communication 细胞间通信center of variation 变异中心centimorgan(cM) 厘摩central dogma 中心法则central tendency 集中趋势centromere DNA 着丝粒DNAcentromere interference 着丝粒干扰centromere 着丝粒centromeric exchange ( CME)着丝粒交换centromeric inactivation 着丝粒失活centromeric sequence( CEN sequence)中心粒序列character divergence 性状趋异chemical genetics 化学遗传学chemigenomics 化学基因组学chiasma centralization 交叉中化chiasma terminalization 交叉端化chimera异源嵌合体Chi-square (x2) test 卡方检验chondriogene 线粒体基因chorionic villus sampling 绒毛膜取样chromatid abemition染色单体畸变chromatid break染色单体断裂chromatid bridge 染色单体桥chromatid interchange 染色单体互换chromatid interference 染色单体干涉chromatid tetrad 四分染色单体chromatid translocation 染色单体异位chromatin agglutination 染色质凝聚chromosomal aberration 染色体崎变chromosomal assignment 染色体定位chromosomal banding 染色体显带chromosomal disorder 染色体病chromosomal elimination 染色体消减chromosomal inheritance 染色体遗传chromosomal interference 染色体干扰chromosomal location 染色体定位chromosomal locus 染色体位点chromosomal mutation 染色体突变chromosomal pattern 染色体型chromosomal polymorphism 染色体多态性chromosomal rearrangement 染色体质量排chromosomal reproduction 染色体增殖chromosomal RNA 染色体RNA chromosomal shift 染色体变迁,染色体移位chromosome aberration 染色体畸变chromosome arm 染色体臂chromosome banding pattern 染色体带型chromosome behavior 染色体动态chromosome blotting 染色体印迹chromosome breakage 染色体断裂chromosome bridge 染色体桥chromosome coiling 染色体螺旋chromosome condensation 染色体浓缩chromosome constriction 染色体缢痕chromosome cycle 染色体周期chromosome damage 染色体损伤chromosome deletion 染色体缺失chromosome disjunction 染色体分离chromosome doubling 染色体加倍chromosome duplication 染色体复制chromosome elimination染色体丢失chromosome engineering 染色体工程chromosome evolution 染色体进化chromosome exchange 染色体交换chromosome fusion 染色体融合chromosome gap 染色体间隙chromosome hopping 染色体跳移chromosome interchange 染色体交换chromosome interference 染色体干涉chromosome jumping 染色体跳查chromosome knob 染色体结chromosome loop 染色体环chromosome lose染色体丢失chromosome map 染色体图chromosome mapping 染色体作图chromosome matrix 染色体基质chromosome mutation染色体突变chromosome non-disjunction染色体不分离chromosome paring染色体配对chromosome polymorphism 染色体多态性chromosome puff染色体疏松chromosome rearrangement染色体质量排chromosome reduplication 染色体再加倍chromosome repeat染色体质量叠chromosome scaffold 染色体支架chromosome segregation 染色体分离chromosome set 染色体组chromosome stickiness染色体粘性chromosome theory of heredity 染色体遗传学说chromosome theory of inheritance 染色体遗传学说chromosome thread 染色体丝chromosome walking 染色体步查chromosome-mediated gene transfer 染色体中介基因转移chromosomology 染色体学CIB method CIB法;性连锁致死突变出现频率检测法circular DNA 环林DNAcis conformation 顺式构象cis dominance 顺式显性cis-heterogenote顺式杂基因子cis-regulatory element 顺式调节兀件cis-trans test 顺反测验cladogram 进化树cloning vector 克隆载体C-meiosis C减数分裂C-metaphase C 中期C-mitosis C有丝分裂code degeneracy 密码简并coding capacity 编码容量coding ratio 密码比coding recognition site 密码识别位置coding region 编码区coding sequence 编码序列coding site 编码位置coding strand 密码链coding triplet 编码三联体codominance 共显性codon bias 密码子偏倚codon type 密码子型coefficient of consanguinity 近亲系数coefficient of genetic determination 遗传决定系数coefficient of hybridity 杂种系数coefficient of inbreeding 近交系数coefficient of migration 迁移系数coefficient of relationship 亲缘系数coefficient of variability 变异系数coevolution 协同进化coinducer 协诱导物cold sensitive mutant 冷敏感突变体colineartiy 共线性combining ability 配合力comparative genomics 比较基因组学competence 感受态competent cell感受态细胞competing groups 竞争类群competition advantage 竞争优势competitive exclusion principle 竞争排斥原理complementary DNA (cDNA)互补DNA complementary gene 互补基因complementation test 互补测验complete linkage 完全连锁complete selection 完全选择complotype 补体单元型composite transposon 复合转座子conditional gene 条件基因conditional lethal 条件致死conditional mutation 条件突变consanguinity 近亲consensus sequence 共有序列conservative transposition 保守转座constitutive heterochromatin 组成型染色质continuous variation 连续变异convergent evolution 趋同进化cooperativity 协同性coordinately controlled genes 协同控制基因core promoter element 核心启动子core sequence 核心序列co-repressor协阻抑物correlation coefficient 相关系数cosegregation 共分离cosuppression 共抑制cotranfection 共转染cotranscript共转录物cotranscriptional processing共转录过程cotransduction 共转导cotransformation 共转化cotranslational secrection 共翻译分泌counterselection 反选择coupling phase 互引相covalently closed circular DNA(cccDNA)共价闭合环状DNA covariation 相关变异criss-cross inheritance 交叉遗传cross 杂交crossability 杂交性crossbred 杂种cross-campatibility 杂交亲和性cioss-infertility 杂交不育性crossing over 交换crossing-over map 交换图crossing-over value 交换值crossover products 交换产物crossover rates 交换率crossover reducer 交换抑制因子crossover suppressor 交换抑制因子crossover unit 交换单位crossover value 值crossover-type gamete 交换型配子C-value paradox C 值悖论cybrid 胞质杂种cyclin 细胞周期蛋白cytidme 胞苷cytochimera 细胞嵌合体cytogenetics 细胞遗传学cytohet 胞质杂合子cytologic 细胞学的cytological map 细胞学图cytoplasm细胞质cytoplasmic genome 胞质基因组cytoplasmic heredity 细胞质遗传cytqplasmic incompatibility 细胞质不亲和性cytoplasmic inheritance 细胞质遗传cytoplasmic male sterility 细胞质雄性不育cytoplasmic mutation 细胞质突变cytofdasmic segregation 细胞质分离cytoskeleton 细胞骨架Darwin 达尔文Darwinian fitness 达尔文适合度Darwinism 达尔文学说daughter cell 子细胞daughter chromatid 子染色体daughter chromosome 子染色体deformylase 去甲酰酶degenerate code 简并密码degenerate primer 简并引物degenerate sequence 简并序列degenerated codon 简并密码子degeneration 退化degree of dominance 显性度delayed inheritance 延迟遗传deletant 缺失体deletion 缺失deletion loop 缺失环deletion mapping 缺失作图deletion mutation 缺失突变denatured DNA 变性DNA denatured protein 变性蛋白denaturing gel 变性胶denaturing gel electrophoresis 变性凝胶电泳denaturing gradient polyacrylamide gel 变性聚丙稀酰胺凝胶density gradient centrifugation 密度梯度离心density gradient separation 密度梯度分离deoxyribonucleic acid-dependent DNA polymerase 依赖于DNA的DNA聚合酶derived line 衍生系derived type 衍生类型developmental genetics 发育遗传学developmental pathway 发育途径dicentric bridge 双粒染色体桥dicentric chromosome 双着丝粒染色体differential staining technique 显带技术differentiation center 分化中心dihaploid 双单倍体,dihybrid 双因子杂种dihybrid cross 双因子杂交dimorphism 二态性diploidization 二倍化diploidize 二倍化diploidized haploid 二倍化的单倍体direct cross 正交direct repeat 同向重复(序列)direct selection 正选择directed mutagenesis 正向突变discontinuous variation 不连续变异distant hybrid 远缘杂种distant hybridization 远缘杂交diversity center 多样性中心diversity curve 多样性曲线diversity gene ( D gene) D 基因diversity indices 多样性指数diversity of species 种的多样性diversity region ( D region) D 区;多变区DNA alkylation DNA 烧化DNA amplification DNA 扩增DNA amplification in vitro DNA 体外扩增DNA amplification polymorphism DNA 扩增多态性DNA breakage DNA 断裂DNA database DNA 数据库DNA degradation DNA 降解DNA denaturation DNA 变性DNA detection DNA 检测DNA distortion DNA 变形DNA duplex DNA 双链体DNA duplicase DNA 复合酶DNA element DNA 单元DNA evolution DNA 进化DNA fingerprint DNA 指纹DNA fingerprinting DNA 指纹分析DNA homology DNA 同源性DNA hybridization DNA 杂交DNA jumping technique DNA 跳查技术DNA melting DNA 解链DNA methylation DNA 甲基化DNA modification DNA 修饰DNA modification restriction system DNA 修饰限制系统DNA nicking DNA 切口形成DNA oxidation DNA 氧化DNA packaging DNA 包装DNA pairing DNA 配对DNA pitch DNA 螺距DNA polymorphism DNA 多态性DNA probe DNA 探针DNA puff DNA 泡DNA purification DNA 纯化DNA recombination DNA 重组DNA redundant 多余DNADNA repair DNA 修复DNA replication DNA 复制DNA replication enhancer DNA 复制增强子DNA replication origin DNA 复制起点DNA replication site DNA 复制点DNA sealase DNA 连接酶DNA sequence analysis DNA 序列分析DNA sizing gene DNA大小决定基因DNA strand exchange DNA 链交换DNA strand separation DNA 链分离DNA strand transfer protein DNA 链转移蛋白DNA template DNA 模板DNA thermal cycler DNA 热循环仪DNA topoisomerase DNA 拓扑异构酶DNA transcript DNA 转录物DNA transposon DNA 转座子DNA twist DNA 扭曲DNA typing DNA 分型DNA untwisting DNA 解旋DNA unwinding enzyme DNA 解旋酶DNA unwinding protein DNA 解旋蛋白DNA-agar technique DNA 琼脂技术DNAase I footprinting DNA 酶I 足迹法DNAase-free reagent 无DNA 酶试剂DNA-binding domain DNA 结合域DNA-binding motif DNA 结合基序DNA-binding protein DNA 结合蛋白DNA-polymerase DNA 聚合酶DNA-protein complex DNA -蛋白质复合体DNA-protein interaction DNA _ 蛋白质相互作用DNA-restriction enzyme DNA 限制酶DNA-RNA hybrid DNA-RNA 杂交体DNase-free 不含DNA 酶的dominance 显性dominance type 优势型dominance variance 显性方差dominant allele 显性等位基因dominant effect 显性效应dominant gene 显性基因dominant gene mutation 显'性基因突变dominant lethal 显性致死dominant phenotype 显性表型donor DNA 供体DNAdonor organism 供体生物dosage compensation 剂量补偿作用dotting blotting 点溃法double crossing over 双交换double fertilization 汉受精duplicate genes 重复基因duplication 重复duplicon 重复子dyad 二分体dynamic selection 动态选择ecological genetics 生态遗传学ecological isolation 生态隔离ecological niche 生态小境ectopic expression 异位表达ectopic integration 异位整合effective population size 有效群体大小embryoid 胚状体embryonic stem cells( ES cells)胚胎干细胞endocrine signal 内分泌信号endogamy 近亲繁殖endomitosis 核内有丝分裂endonuclease 内切核酸酶endopolyploidy 核内多倍体environment 环境environmental variance 环境方差environmental variation 环境变异epigenesis 后成说epigenetic inheritance 后生遗传epigenetically silenced 后生沉默episome 附加体epistasis 上位性epistatic dominance 超显性epistatic gene 上位基因equal segregation 均等分离equational division 均等分裂equilibrium population 平衡群体Expressed Sequence Tag(EST)表达序列标签euchromatin 常染色质euchromatin常染色质eugenics 优生学euhaploid 整单倍体eukaryote 真核生物eukaryotic chromosome 真核染色体eukaryotic cell 真核细胞eukaryotic organism 真核生物eukaryotic vector 真核载体euphenics 优型学euploid 整倍体evolutional load 进化负荷evolutionary divergence 进化趋异evolutionary genetics 进化遗传学evolutionaiy rate 进化速率excision repair 切除修复exconjugant 接合后体excretion vector 分泌型载体exit site 萌发点exogenote 外基因子exogenous gene 外源基因exonuclease 外切核酸酶expression cloning 表达克隆expression library 表达文库expression mutation 表达突变expression plasmid 表达质粒expression product 表达产物expression screening 表达筛选extinguisher loci 消失基因座,灭绝基因座extirpated species 绝迹种extrachromosomal inheritance 染色体外遗传extra-chromosome 超数染色体,额外染色体extranuclear inheritance 核外遗传F1 generation F1代,子一代F2 generation F2 代,子二代facultative heterochromatin 兼性异染色质familial trait 家族性状family selection 家系选择feedback suppression 反馈抑制female gamete 雌配子fertility factor 致育因子filial generation 子代fingerprint 指纹finite population 有限群体first division segregation 第一次分裂分离first division segregation pattern 第一次分裂分离模式flanking sequence 侧翼序列flow cytometry 流式细胞仪fluorescence in situ hybridization ( FISH )荧光原位杂交fluorescent primer 荧光引物fluorescent probe 荧光探针formyl methionine (fMet)甲酰甲硫氨酸foot printing 足迹法foreign DNA 外源DNAforward genetics 正向遗传学forward mutation 正向突变forward primer 正向引物founder effect 建立者效应four strand double crossing over 四线双交换full-sib 全同胞functional genomics 功能基因组学functional RNA 功能RNAgain-of-function mutation 功能获得性突变gamete 配子gametic 配子的gametic incompatibility 配子不亲和性gametic lethal 配子致死gametic linkage 配子连锁gametic meiosis 配子减数分裂gametic ratio 配子分离比gametoclonal variation 配子无性系变异gametophyte 配子体G-band G带;中期染色体带GC box GC 框GC tailing GC 加尾gel electrophoresis 凝胶电泳gemetic sterility 配子不育gene activation 基因激活gene activity 基因活性gene amplification 基因扩增gene analysis 基因分析gene arrangement 基因排列gene balance 基因平衡gene basis 基因基础gene batteries 基因群gene block 基因区段gene carrier 基因携带者gene center theory 基因中心学说gene cluster 基因簇gene combination 基因重组gene complex 基因复合体gene content 基因含量gene conversion 基因转换gene distribution 基因分布gene diversity 基因多样性gene dosage 基因剂量gene dosage compensation 基因剂量补偿gene dosage effect 基因剂量效应gene duplication 基因重复gene element 基因元件gene exchange 基因交流gene expression 基因表达gene expression system 基因表达系统gene family 基因家族gene fixation 基因固定gene flow 基因流gene frequency 基因频率gene fusion 基因融合gene inactivation 基因失活gene inoculation 基因接种gene interaction 基因相互作用gene isolation 基因分离gene knockout 基因敲除gene knock-out 基因失效法gene linkage 基因连锁gene localization 基因定位gene location 基因位置gene locus 基因位点gene magnification 基因扩增gene manipulation 基因操作gene map 基因图谱gene mapping 基因作图gene multiplication 基因重复gene mutation 基因突变gene mutation rate 基因突变频率gene order 基因次序gene organization 基因组构gene pool 基因库gene position effect 基因位置效应gene probe 基因探针gene product 基因产物gene rearrangement 某因重排gene reassortment 基因重新配对gene replication 基因复制gene repression 基因抑制gene resortment 基因重配gene silencing 基因沉默gene splicing 基因剪接gene string 基因线gene structure 基因结构gene substitute 基因置换gene substitution 基因置换gene suppression 基因抑制gene synthesis 基因合成gene tagged 基因标签gene tagging 基因标签gene targeting 基因导向,基因寻靶gene transfer 基因转移gene transfer agent 基因传递因子gene transfer vector 基因转移载体gene transposition 基因转座genealogical classification 系谱分类genera 属general transcription factor ( GTF )通用转录因子generalized transduction 普遍性转导generation 世代generative cell 生殖细胞generative reproduction 有性繁殖generic coefficient 种属系数generic cross 属间杂交generic name 属名genes in common 共同基因gene-specific transcription factor 基因特异性转录因子genetic ablation 基因缺损genetic advance 遗传进度genetic algebra 遗传代数genetic analysis 遗传分析genetic background 遗传背景genetic balance 遗传平衡genetic block 遗传性阻碍genetic compensation 遗传补偿genetic complementation 遗传互补genetic composition 遗传组成genetic continuity 遗传连续性genetic control 遗传控制genetic covariance 遗传协方差genetic cross 杂交genetic database 遗传数据库genetic death 遗传性死亡genetic deficiency 遗传缺损genetic deformity 基因变型genetic determinant 遗传决定因子genetic dimorphism 遗传二型现象genetic distance 遗传距离genetic divergence 遗传趋异genetic diversity 遗传多样性genetic dominance 遗传优势genetic donor 基因供体genetic drift 遗传漂变genetic element遗传因子,遗传成分genetic engineering 遗传工程genetic equilibrium 遗传平衡genetic erosion 遗传冲刷,遗传蚀变genetic expression 遗传表达genetic extinction 遗传灭绝genetic facilitation 遗传促进作用genetic factor 遗传因子genetic feedback 遗传反馈genetic fingerprint 遗传指纹genetic fingerprinting 遗传指纹分析genetic fitness 遗传适合度genetic flexibility 遗传可塑性genetic gain 遗传获得量genetic heterogeneity 遗传异质性genetic homology 遗传同源genetic immunity 遗传免疫genetic imprinting 遗传印记genetic inertia 遗传惰性genetic information 遗传信息genetic inoculation 基因接种genetic instability 遗传不稳定性genetic continuity 遗传连续性genetic control 遗传控制genetic covariance 遗传协方差genetic cross 杂交genetic database 遗传数据库genetic death 遗传性死亡genetic deficiency 遗传缺损genetic deformity 基因变型genetic determinant 遗传决定因子genetic dimorphism 遗传二型现象genetic distance 遗传距离genetic divergence 遗传趋异genetic diversity 遗传多样性genetic dominance 遗传优势genetic donor 基因供体genetic drift 遗传漂变genetic element遗传因子,遗传成分genetic engineering 遗传工程genetic equilibrium 遗传平衡genetic erosion 遗传冲刷,遗传蚀变genetic expression 遗传表达genetic extinction 遗传灭绝genetic facilitation 遗传促进作用genetic factor 遗传因子genetic feedback 遗传反馈genetic fingerprint 遗传指纹genetic fingerprinting 遗传指纹分析genetic fitness 遗传适合度genetic flexibility 遗传可塑性genetic gain 遗传获得量genetic heterogeneity 遗传异质性genetic homology 遗传同源genetic immunity 遗传免疫genetic imprinting 遗传印记genetic inertia 遗传惰性genetic information 遗传信息genetic inoculation 基因接种genetic instability 遗传不稳定性genetic interaction 遗传相互作用genetic isolating factor 遗传隔离因子genetic isolation 遗传隔离genetic knock-out experiment 基因失效试验genetic linkage 遗传连锁genetic linkage map 遗传连锁图谱genetic load 遗传负荷genetic manipulation 遗传操作genetic map 遗传图谱genetic mapping 遗传作图genetic marker 遗传标记genetic masking 基因组掩饰genetic material 遗传物质genetic mobilization 遗传转移genetic modification 遗传修饰genetic module 遗传组件genetic nomenclature 遗传命名法genetic parameter 遗传参数genetic polarity 遗传极性genetic polymorphism 遗传多样性genetic population 遗传群体genetic potential 遗传潜力genetic process 遗传过程genetic property 遗传特'性genetic ratio 遗传比genetic reactivation 遗传复活genetic reassortment 遗传重排genetic recipient 基因受体genetic recombination 遗传重组genetic regulation 遗传调节genetic relationship 亲缘关系genetic repair mechanism 遗传修复机制genetic replication 遗传复制genetic risk 遗传危险性genetic screening 遗传筛查genetic segregation 遗传分离genetic selection 遗传选择genetic sex 遗传性别genetic shift 遗传漂移genetic stability 遗传稳定性genetic sterility 遗传性不育genetic strain 遗传品系genetic suppression 遗传抑制genetic switch 遗传开关genetic system 遗传体系genetic transcription 遗传转录genetic transformation 遗传转换genetic translation 遗传翻译genetic transmission 遗传传递genetic typing 遗传分型genetic unit 遗传单位genetic value 遗传值genetic variability 遗传变异性genetic variance 遗传方差genetic vulnerability 遗传易损性genetic“hot spot” 遗传“热点”genetical marker 遗传标记genetical non-disjunction 遗传不分离genetical population 遗传群体genetically heterogeneous 遗传异质的genetically modified organism 基因修饰生物genetics correction 遗传修正genetics of resistance 抗性遗传genetype 基因型genic balance 基因平衡genome allopolyploid 基因组异质多倍体genome amplification 基因组扩增genome evolution 基因组进化genome mapping 基因组作图genome project 基因组计划genome rearrangement 基因组重排genome sequencing 基因组测序genomic exclusion 基因组排斥genomic fingerprinting 基因组指纹分析genomic footprinting 基因组足迹分析genomic imprinting 基因组印记genomic instability 基因组不稳定性genomic library 基因组文库genomic walking 基因组步查genotypic frequency 基因型频率genotypic ratio 基因型比值genotypic value 基因型值genotypic variance 基因型方差geographic speciation 地理型新种形成geographical isolation 地理隔离geographical polymorphism 地理多态现象germ layer 胚层germ line 种系germ nucleus 生殖核germ plasm 种质germinal mutation 生殖细胞突变germ-line gene therapy 种系基因治疗giant chromosome 巨型染色体global homology 总体同源性global region 全局调节子globular protein 球蛋白group selection 集团选择。

ZnO_基Z_型异质结结构光催化性能研究进展

ZnO_基Z_型异质结结构光催化性能研究进展

表面技术第52卷第11期ZnO基Z型异质结结构光催化性能研究进展吴敏科,任璐*,任瑞祥,李家豪,赵超凡,余洋(苏州科技大学 土木工程学院,江苏 苏州 215011)摘要:氧化锌(ZnO)作为一种常见的光催化剂,存在光能利用率低、效率低、易失活等缺陷,限制了其广泛应用。

通过与带隙结构匹配的半导体材料构筑异质结结构,是解决上述问题的有效途径。

其中,Z型异质结结构是一种新型异质结,由于其电子转移过程构成了英文字母Z的形状,因而称之为Z型异质结。

在光生载流子迁移上,Z型异质结具有独特的结构特点。

不仅能够增加光生电子与空穴的分离效率,还能保持较高的氧化还原能力。

系统地从Z型异质结、二元Z型异质结结构、三元Z型异质结结构3个方面综述了近期ZnO基Z型异质结结构在光催化方面的研究进展。

对ZnO与半导体氧化物、半导体硫化物及其他半导体材料构成二元Z型异质结的机理及其催化性能的提高进行了概括总结。

梳理了三元异质结的光催化机理及三元Z型异质结在光催化性能上的优势。

最后对Z型异质结的研究进行总结,为纳米ZnO光催化氧化技术的应用发展提供参考。

关键词:氧化锌;Z型异质结;光催化;半导体;有机污染物中图分类号:O649.2 文献标识码:A 文章编号:1001-3660(2023)11-0200-16DOI:10.16490/ki.issn.1001-3660.2023.11.015Research Progresses on Photocatalytic Properties of Z-schemeHeterojunction Structures Based on ZnOWU Min-ke, REN Lu*, REN Rui-xiang, LI Jia-hao, ZHAO Chao-fan, YU Yang(School of Civil Engineering, Suzhou University of Science and Technology, Jiangsu Suzhou, 215011, China)ABSTRACT: As a common photocatalyst, Zinc oxide (ZnO) has some defects, such as poor utilization of light energy, low efficiency and easy deactivation, which limit its wide applications. It is one of the hotspots to solve the above problems to construct ZnO-based heterojunction structures by selecting semiconductor materials that can match the ZnO-band gap structure.Recently, forming Z-scheme heterojunction of ZnO is a new approach to improve its photocatalytic performance because its electron transfer process forms the shape of the English letter "Z". This paper systematically introduced the research progress of nano ZnO photocatalytic efficiency improvement from three aspects: Z-scheme heterojunction structure, binary Z-scheme heterojunction structure, and ternary Z-scheme heterojunction structure. Firstly, heterojunction structures and Z-scheme heterojunction structure were explained in details. Heterojunction structures referred to the contact interfaces between two semiconductor materials with different band structures. Among them, Type-Ⅱtype heterojunction structures were arranged in a收稿日期:2022-08-15;修订日期:2023-03-01Received:2022-08-15;Revised:2023-03-01基金项目:国家自然科学基金(51902219);江苏省自然科学基金(BK20190949);苏州科技大学大学生创新训练项目(202110332040Y)Fund:National Natural Science Foundation of China (51902219); Natural Science Foundation of Jiangsu Province (BK20190949); Innovative Training Program for College Students of Suzhou University of Science and Technology (202110332040Y)引文格式:吴敏科, 任璐, 任瑞祥, 等. ZnO基Z型异质结结构光催化性能研究进展[J]. 表面技术, 2023, 52(11): 200-215.WU Min-ke, REN Lu, REN Rui-xiang, et al. Research Progresses on Photocatalytic Properties of Z-scheme Heterojunction Structures Based on ZnO[J]. Surface Technology, 2023, 52(11): 200-215.*通信作者(Corresponding author)第52卷第11期吴敏科,等:ZnO基Z型异质结结构光催化性能研究进展·201·staggered manner of the two bands, which was the most studied traditional heterojunction structure. Different from Type-Ⅱtraditional heterojunction, the specific carrier migration process of Z-scheme heterojunction structure was as follows: the electrons in the conduction band of the semiconductor Ⅱrecombined with the holes in the valence band of the semiconductor Ⅰ. Meanwhile, the residual electrons mainly existed in the conduction band of semiconductorⅠ, and the holes mainly existed in the valence band of semiconductor Ⅱ. Thus, Z-scheme heterojunction structure had a higher separation efficiency of photogenerated carriers and maintained a high redox capacity. Secondly, ZnO-based binary Z-scheme heterojunction structures were discussed and the mechanisms of the improved of catalytic performance were summarized. Those binary Z-scheme heterojunctions were formed by ZnO with semiconductor oxides (e.g. WO3/ZnO, TiO2/ZnO, CeO2/ZnO, Cu2O/ZnO), semiconductor sulfides (e.g.ZnS/ZnO, CdS/ZnO), and other semiconductor materials (e.g.g-C3N4/ZnO, Ag3PO4/ZnO). The photogenerated electrons retained in the conduction band of ZnO or matched semiconductor maintain high reduction capacity, and the photogenerated holes retained in the valence band of matched semiconductor or ZnO maintain high oxidation capacity.Eventually, the composite catalyst showed better photocatalytic activity. The binary Z-scheme heterojunction constructed with the visible-light semiconductor catalyst could also promote the light response range of ZnO-based photocatalyst from ultraviolet light to visible light, which improved the utilization of light energy, and solved the limitation of ZnO excited only by ultraviolet light. Thirdly, the photocatalytic mechanism of ternary heterojunction and the advantages of ternary Z-scheme heterojunction in photocatalytic performance were reviewed.The ZnO-based ternary Z-scheme heterojunction structure was more complex than the binary heterojunction in terms of composition and charge migration. The most common type of ternary Z-scheme heterojunction was the inclusion of noble metal as an intermediate electron medium between two semiconductor materials (e.g. ZnO-Ag-BiVO4, ZnO-Au-ZnAl2O4).The ternary Z-scheme heterojunction structure of noble metal-ZnO system also could be built through the ZnO-based binary Z-scheme heterojunctions further modified by noble metals (e.g.Au-g-C3N4-ZnO). Other constructions of ternary Z-type heterojunctions were composed of three kinds of semiconductor materials, resulting in a double Z-scheme charge transport (e.g.ZnO/ZnWO4/g-C3N4, Bi2MoO6/ZnSnO3/ZnO). Finally, the research prospect of Z-scheme heterojunctions was summarized.Compared with pure ZnO photocatalyst, ZnO-based Z-scheme heterojunction structure had more potential in the catalysts design, and had more advantages in degradation of organic pollutants, hydrogen production and other photocatalysis. That provides a reference for the design, preparation and performance improvement of other semiconductor materials.KEY WORDS: ZnO; Z-scheme heterojunction; photocatalysis; semiconductor; organic pollutants半导体氧化物具有优异的光催化性能,在环境治理、能源和资源等方面具有很大的应用潜力。

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向于认为, 在群落构建中生态位理论和中性理论并 非对立, 将生态位理论和中性理论整合可以更好地 理解群落构建的机理 (Tilman, 2004; Chase, 2005; Gravel et al., 2006; Leibold & McPeek, 2006)。 本文试图在简要回顾群落中性理论和生态位 理论发展的基础上, 梳理其最新研究进展, 并探讨 整合生态位理论和中性理论, 解释群落构建和多样 性维持的可能途径。
Biodiversity Science
群落构建的中性理论和生态位理论
牛克昌1* 刘怿宁1 沈泽昊1 何芳良2 方精云1
1 (北京大学城市与环境学院生态学系, 北京大学地表过程分析与模拟教育部重点实验室, 北京 100871) 2 (Department of Renewable Resources, University of Alberta, Edmonton, Alberta, Canada T6G 2H1)
1
群落构建的生态位理论
关于群落多样性的形成和维持机理, 主要存在
两类不同的观点。一种观点认为, 在群落构建和多 样性维持中, 共存物种间的生态位分化等确定性因 素占主导地位; 而另一种观点则认为扩散和随机作 用是主要决定因子。关于群落构建的确定性和非确 定性因素, 达尔文在其巨著《物种起源》中早有所 提及。他认为看似偶然生长在一起的群落物种, 其 背后有着深刻的必然性。而对确定性因素和随机作 用在群落构建中的地位较为系统的讨论, 可以追溯 到20世纪初的群落超有机体论(super-organism concept) (Clements, 1916; Tansley, 1935) 和 个 体 论 (individualistic concept)(Gleason, 1926) 的争论。以 Clements为代表的群落有机体学派认为, 群落构建 是确定性过程, 群落之间有着可分辨的边界, 群落 在受干扰后能够逐渐演变到原来的状态, 即群落演 替; 在群落组分种的相互作用下, 演替是从一个方 向有规律地向另一个方向变化, 演替的最后阶段是 稳定的单元顶极(monoclimax)(Clements, 1916)或多 元顶极(polyclimax)(Tansley, 1935)。 对此, 以Gleason 为代表的群落个体学派提出了猛烈的批评, 他们认 为群落只是一些物种的随机组合, 群落之间并没有 明显的界限 , 群落结构变化也没有明确的方向性 , 各物种以其独特的方式响应着环境的时空变化。其 后, 岛屿生物地理学的出现、 群落构建规则的提出以 及群落中性理论的蓬勃发展, 将群落构建中确定性 作用和随机过程的相对重要性的讨论推向了高潮。 1.1 生态位和物种共存机制 早在1910年Johnson就率先提出了生态位概念。

学习进阶理论视阈下的高中英语教学实践与研究

English Teachers
Vol.17 No.21
策略与方法
学习进阶理论视阈下的高中英语教学实践与研究
周 绘 【摘 要】 阐述学习进阶理论的内涵, 以学习进阶理论为导向, 从学生的视角探寻学习进阶理论 构建学习进阶图; 自我分层, 巧搭学习进阶; 在高中英语教学中的引用。从目标导向, 梯度设计, 构建思维进阶; 关联结构, 优化进阶路径四个方面分析学习进阶理论的应 用过程。认为应用学习进阶理论能有效促进学生自我发展。 高中英语; 自我发展 【关键词】 学习进阶理论;
↑ ↑
喜剧表演 → 单口戏剧分类型 ←


学习路径
单口相声 → Stand-up 概念 ← 上下文猜测 进阶起点 认知发展过程
图1 通过构建学习进阶图, 既能让教学目标明确清 更能 晰, 又能让学生对核心概念的学习更加深入, 增强学生对相关知识理解的连贯性。 巧搭学习进阶 (二) 自我分层, 通过学 学习进阶是指遵循学生思维发展特点, 鉴 习路径的搭建实现学生思维水平的螺旋式上升。 于每一位学生的学习都存在很大的差异性, 教师可 以传授学生自我分层的方法,实现学生自主学习, 促进学生自由发展。 在讲授牛津译林版高中 《英语》 必修 1 Unit 1 School life 的词汇时,为了让学生更好地掌握如下 available, context, extra, donate, relax, experi词汇: ence, assemble, attend, display,笔 者根据层 级划分 即: (1) 标准引导学生自我分层, 理解单词的多种含 (2) 掌握相关搭配, 并能理解其 义, 并能正确拼写; 同时, 能够利用所学词汇遣 在文章中的具体运用, 自主 词造句; (3) 能够灵活运用词汇进行语言表达, 引导学 积累相应词汇的用法。通过制订层级标准, 当他们完成相应 生针对自己的情况确定学习阶层, 层级任务并达到标准时,便会顺利地上升到高层 这样, 学生就能根 级, 从而实现对自我分层的划分。 “阶” , 据自我认知发展过程, 灵活确定自己跨越的 从而促进自我发展。 (三) 梯度设计, 构建思维进阶 学习进阶的最终目的是学生在认 知过程中拾 级而上, 促进思维进阶的发展。这要求教师根据学 ,为其搭建不断提升的“脚手 生的“最近发展区” 层层推进, 让不同水平的 架” , 引导他们由浅入深、 教师可以按 学生都能在相应的层级上获得成就感。 照由简单到复杂的逻辑顺序设置具有梯度性的学 促使他们都 习任务, 激发每一位学生的学习潜能, 能在原有水平上获得提升。 必修 5 Unit1 Getting 以牛津译林版高中 《英语》 along with others 中 Reading 部 分 Secrets and Lies 教学为例,教学目标是学生能准确理解信件内容、 admit, pretend, for分析 长 难 句 并 掌握 词 汇 betray, give, swear, manner , guilty , argue , senstitive, focus, dislike, blame sb. for doing sth., apologize to sb. for doing sth., make cruel remarks on 等。 笔者根据学生 设置了三个层次的学习目标: (1) 的 “最近发展区” 掌握上述词汇的使用方法,至少掌握一种阅读 技 并能准确理解信件的主 巧, 完成信件的自主阅读, A. I (2) 学会分析长难句: 要内容,完成阅读题目; must have sounded very proud of myself after the quiz, saying how easy it was and how I was sure to get a good grade. B. He got annoyed, saying it wasn’ t

英语B级考试练习题

2017英语B级考试练习题(二)25.I’m sorry to tell you that the materials you wanted are .A)taken off C)sold outB)put up D)got off26.Some companies might not let you rent a car you have a credit card.A)taken off C)sold outB)put up D)got off27.Our company’s service is in nearly 80 countries around the world.A)available C)relativeB)natural D)careful28.I‘m told that I will share an office room five other newcomers.A)in C)toB)with D)at29.Can you help me to a sales plan in that area.A)set up C)put onB)give in D)work out30.Those are interested in the job position need to send an email to us.A)what C)whichB)whom D)who31.I’m pleased to tell you that the fax machines you ordered are now.A)available C)wonderfulB)convenient D)important32.We have got to a new way to solve this problem.A)turn out C)think ofB)put out D)take over33.The Quality Control staff is responsible the quality of the products that come out of the factory.A)for C)withB)of D)to34. the members cooperate well,the team will keep winning games.A)In case of C)As long asB)As well as D)In addition to35.The money (borrow) from the bank has already been paid back.36.It won’t make any(different)whether he comes to the meeting or not.37.The machine should(test) before it is put to use.38.(fortunate) ,you have many articles online to help you in finding a job.39.In order to keep a high level of safety,all the staff are required(wear) protective clothes.To: All Manager and Department HeadsSubject: New Communication Training ProgramClear, friendly, efficient communication skill are essential for building relationships withyour customers. You can use it for the business. A new online training program is available on the Learn Well website. It will help Company empl oyees create “customer-friendly” communication.Please visit the website for a memo from the organizer. The memo provides a general view of this customer-friendly communication training program. It also explains how employees can register for the online training. Please forward this email to you employees and encourage them to sign up for training at their leisure time as soon as possible.Thank you for your support as we work to improve your employees’ customerA ………………… Employee relationsB ……………… interests and hobbiesC ………………… personal dat aD ………………... degree certificateE ………………... first nameF ………………… last nameG .………………... marital statusH ………………… date of birthI …………………. Annual salaryJ …………………. NationalityK----------- Contract of serviceL ………………… work ex perienceM …….…………. education backgroundN ………………… sexO ………………….. Unemployment insuranceP …………………... Minimun wage说明:假定你是公司IT部经理David Chen,根据下列内容给公司各部门经理写一封内部通知(Memo)。

第十四届中国金融学年会论文入选名单

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Behavioral-Level Synthesis of Heterogeneous BISR Reconfigurable ASIC’s Lisa M.Guerra,Miodrag Potkonjak,Member,IEEE,and Jan M.Rabaey,Fellow,IEEEAbstract—In this paper,behavioral-level synthesis techniques are presented for the design of reconfigurable hardware. The techniques are applicable for synthesis of several classes of designs,including1)design for fault tolerance against permanent faults,2)design for improved manufacturability, and3)design of application specific programmable processors (ASPP’s)—processors designed to perform any computation from a specified set on a single implementation platform. This paper focuses on design techniques for efficient built-in self-repair(BISR),and thus directly addresses the former two applications.Previous BISR techniques have been based on replacing a failed module with a backup of the same type.We present new heterogeneous BISR methodologies which remove this constraint and enable replacement of a module with a spare of a different type.The approach is based on theflexibility of behavioral-level synthesis to explore the design space.Two behavioral synthesis techniques are developed;thefirst method is through assignment and scheduling,and the second utilizes transformations.Experimental results verify the effectiveness of the approaches.Index Terms—Behavioral-level synthesis,built-in-self-repair (BISR),fault tolerance,transformations.I.I NTRODUCTIONW ITH the rising cost of semiconductor manufacturing and the increasing complexity of integrated circuits, improvement of manufacturing yields is crucial for achieving economic utilization of semiconductor manufacturing facil-ities.Fault tolerance techniques such as the built-in self-repair(BISR)sparing methodology will play an important role in achieving yield improvements.BISR is a hybrid redundancy technique in which a set of spare modules are provided in addition to the core operational modules[1].If an implementation is found to have defective core modules, these modules can be replaced by functional spare ones before packaging.BISR methods can be applied not only for yield im-provement but also for improvement of design reliability. Designs can be made fault tolerant to failures occurring during operation by automatic replacement of failed modules with spare ones,so that the overall system can continue to function correctly.This is especially important in military systems and space exploration missions[1]where it is critical that there are no system failures,or where manual replacement of failed modules is either impossible or prohibitively expensive. Manuscript received January15,1996;revised July9,1997.L.M.Guerra and J.M.Rabaey are with the Department of Electrical Engineering and Computer Science,University of California at Berkeley, Berkeley,CA94720USA.M.Potkonjak is with the Computer Science Department,University of California at Los Angeles,Los Angeles,CA90095USA.Publisher Item Identifier S1063-8210(98)01315-8.This paper introduces a novel concept of Heterogeneous BISR for ASIC designs.As opposed to traditional BISR,where a failed module is replaced by a spare of the same type, we propose Heterogeneous BISR(HBISR),which enables replacement of a module with a spare of a different type. HBISR leverages on a computation’sflexibility,or its ability to be implemented in a number of competitive ways,to increase productivity and fault tolerance.In addition,behavioral-level synthesis techniques for exploiting thisflexibility in automated design are presented.One method is through assignment and scheduling,and the second utilizes transformations.The paper is organized in the following way.After a survey of previous works and discussion of several design preliminaries,simple,yet real-life examples are used to in-troduce the main ideas.Next,new behavioral-level synthesis algorithms which minimize hardware overhead for HBISR during resource allocation,assignment,scheduling,and trans-formations are discussed.The paper concludes by presenting and analyzing experimental results on a variety of real-life DSP examples and briefly outlining extensions.II.P REVIOUS W ORKThe main target for BISR techniques are systems that are bit-,byte-,or digit-sliced.By far the most important use of bit-sliced BISR is in SRAM and DRAM circuits[2],[3].Almost all current day memory designs use BISR techniques[4],as they significantly increase memory production profitability. Programmable logic arrays are another class of bit-sliced devices for which BISR has been well addressed[5],[6].It has also been successfully applied for arithmetic-logic unit byte slices[1].Other areas in which BISR techniques are being used include secondary storage systems[7],wafer scale integration[8],and systolic array designs[9].While all previous BISR techniques have been based on replacing a failed module with a backup of the same type,we present new heterogeneous BISR methodologies.Additionally, we present synthesis techniques for their design.Behavioral-level synthesis provides theflexibility of design space explo-ration so that a variety of design goals can be addressed. An overview and extensive bibliography of behavioral-level synthesis algorithms can be found in[10]and[11].Most of these works,target the optimization of area and speed (throughput).Recently,other important goals,such as power, testability,and reliability and fault tolerance have been ad-dressed.Little work has been reported on behavioral-level synthesis techniques for reliable and fault tolerant design. Raghavendra and Lursinsap[12]concentrated on designs with self-recovery from transient faults using micro roll-1063–8210/98$10.00©1998IEEEback and checkpoint insertion.Karri and Orailoglu presented scheduling and assignment and transformation-based methods for minimizing hardware overhead while achieving a certain level of fault tolerance in micro roll-back[13].While previous behavioral-level synthesis methods for enhancing fault toler-ance have addressed intermittent and transient faults[1],this work concentrates on permanent faults where fault tolerance is used for reliability,yield,and productivity enhancement. III.I SSUES IN HBISR R ECONFIGURABLE D ATAPATH D ESIGN Given a behavioral description of the algorithm,an under-lying hardware model,and a throughput constraint,the goal is to synthesize a minimum area design that can tolerate a number of faulty hardware resources.This section describes our targeted application and computation and hardware mod-els,as well as several implementation issues in the design of reconfigurable datapaths for HBISR design.Targeted applications include real-time DSP,video,multi-media,and other numerically intensive algorithms.Applica-tions are represented as hierarchical data-controlflowgraphs, with nodes representing theflowgraph operations,and edges the data and control dependencies between them[14].The underlying model of computation is the homogeneous syn-chronous dataflow model of[15].The ASIC hardware model being considered is the dedicated register model,where all registers are clustered in registerfiles, connected only to the inputs of the corresponding execution units[14].We also assume that there is no bus merging, so there exists a dedicated bus connecting any two units between which there are data transfers.Note that the HBISR methodology itself is not limited to this hardware model; generalizations are discussed in Section VII.At the gate level,a single stuck-at model[16]is assumed for faults,and at the register transfer level,we assume that a unit is faulty if it has one or more gate level faults.Faults can occur in either an execution unit,registerfile,or bus.Under the targeted hardware model and these assumptions,all faults can be classified as execution unit faults.A faulty register file prevents its corresponding execution unit from receiving data,and thus has the same effect as a fault in the execution unit.Similarly,a faulty bus can be treated as a failure in the execution unit at its receiving end.Note again that the HBISR methodology itself is general,and can be easily extended to other fault models.A number of testing approaches are available to detect that a fault exists,and to diagnose its location[16].If BISR is used to improve manufacturability,any off-line testing and diagnosis scheme can be used[i.e.,partial-scan sequential automatic test pattern generation(ATPG),full-scan and combinational ATPG, built-in self-test(BIST),and insertion-point based-schemes]. Note that any scheme which does not have strong diagnosis capabilities(e.g.,IDDQ-based testing),cannot be used.If the BISR methodology supports in-field reconfiguration after failure of particular hardware part(s),a BIST scheme is required.In this case,testing capabilities are“built-in”(resulting in test-hardware overhead)to the chip itself.The BIST scheme can be either on-line or off-line[16].In the off-line BIST scheme,periodic interruption of the functional mode is required.Upon diagnosis of a fault,the controller is reconfigured. Several alternatives for efficient low overhead controller im-plementation include programmable,off-chip,or composed controllers.A programmable controller[17]often brings a somewhat large implementation area and a small degradation in performance,but it providesflexibility not only for HBISR, but also for relatively minor alterations in the chip functional-ity as is often required in modern day designs.An off-chip controller can be replaced as necessary since it is located on a separate chip.A number of high performance datapath intensive chips have used this option(e.g.,[18]).The same drawbacks and advantage as with the programmable controller hold.The composed controller is located on-chip,and is the composition of all possible control configurations that may be used.Its effectiveness depends on how well several different (but often similar)controllers can be merged.In all cases we assume that the controller itself is fault-free. This assumption can be easily replaced by a fault-tolerance mechanism which provides resiliency of the controller.Since the controller usually occupies a very small fraction of chip area in datapath-intensive ASIC designs[14],simple replica-tion is often an adequate solution.IV.A SSIGNMENT AND S CHEDULING FOR HBISR D ESIGN A.Key Ideas and Motivational ExampleProbably the most straightforward approach to BISR is to provide a spare for each hardware instance,resulting in full duplication of the hardware.With the detection of a faulty unit, reconfiguration takes place to initiate use of its spare.This reconfiguration is conceptually a switch that passes control from the failed to the backup unit.Fortunately,the BISR overhead need not be so high.If the number of faultyunits,units are faulty.The main ideas are illustrated with the following example (Fig.1,Table I),where the goal is a low-overhead HBISR implementation that can tolerate up to one faulty unit.The ex-ample includes the imaginary part of a complex number mul-tiplication with a constant and with a variable(multiplication with a constant is such that it can be done using a single shift).(a)(b)Fig.1.Scheduling and assignment for HBISR:Imaginary part of com-plex multiplication:(a)with constant multiplications and (b)with variable multiplications.TABLE IS CHEDULES FOR THE E XAMPLE OF F IG .1,TO BE U SED W HEN AN A DDER ,S HIFTER ,OR M ULTIPLIER FAILSAssume that each operation takes one control cycle and the available time is three control cycles.The minimum hardware required for non-BISR implementation consists of two shifters,one multiplier,and one adder.If scheduling flexibility is not exploited,the minimum BISR hardware will require an addi-tional unit of each type.However,using both assignment and scheduling,only two shifters,two multipliers,and two adders are needed.If the adder fails,operations A and B are done on the two shifters in step 1,D and E on the two multipliers also in step 1,and C and F on the single remaining adder in steps 2and 3.Table I shows the schedules for all three cases of failed units.An important point to note is that no additional shifters are needed.In the event of a shifter failure,the scheduling flexibility brought by the redundant multiplier is exploited.B.Allocation,Assignment,and Scheduling Algorithm The global strategy of the Hyper behavioral-level synthesis system [19]is well suited for use as the starting point for developing new algorithms targeting HBISR.In this system,allocation first proposes a hardware solution,then assignment and scheduling are performed to check its feasibility.To take into account BISR requirements,it was necessary to develop a new allocation scheme.A generic assignment and scheduling module can easily be modified for use within this framework.We have used the Hyper scheduler and assigner,with small modifications.Before explaining the details of the new allocation algo-rithm,several definitions are presented.Anallocation,,there are many possiblecombinationsof,.Note that the number of elements .A feasibleallocation,.The basic idea of the allocation mechanism is to start at an initial allocation,add hardware until a feasible allocation is found,then remove all unnecessary redundant hardware.Note that for any proposed allocation solution,it is necessary to assure that scheduling can succeed with any combinationof.The pseudo-code for the global flow is presented below,followed by an explanation of the algorithm’s key components.GetInitialAllocation();while(!Success)Success =Assign and ScheduleWithFailed Unit(j)if(!Success)break;AddHardware();is used as the initialallocation.is a minimum boundon the amount ofhardwareis the number of faults.Foreach hardwareclass,units oftyperarely entered,but assures a solution will be found if one exists.At the completion of the expansion phase,there is no guarantee that the feasible allocation is minimal.It is possible that a subset of theallocation,to be the set of failed childallocations.Let,thenthreeadders,two subtracters,twomultipliers(adder)two adders,two subtracters,twomultiplierswassuccessful.At this point,the removal phase is entered.At first glance,knowingthat three adders,two sub-tracters,twomultiplierssucceeded,it is not clearwhat will happenwith two adders,three subtracters,twomultipliersfrom considerationsince,(subtracter),(adder),(multiplier)since(subtracter)whose relaxed schedulingminimum hardware bound(),are difficult to schedule.The absolute minimum bound [20]for hardwaretypeNumNodes ,where NumNodes,durationis the numberof allowable faulty units.The minimum bounds stress for hardwaretype-critical network stress,C:If a high percentage of thenodes of a particular hardwaretype-critical network consists of all operationson paths which have lengths within asmall-critical network stressfor hardwaretypeNetNumNodes),is calculated for eachoperation,,to give the unnormalized stressstress(3)Since we are interested in the minimum area solution,we normalize the stress value by the hardware cost of the unit,giving the scheduling stress for hardwaretypeNodes(4)(a)(b)Fig.2.Transformations for HBISR:using associativity and the inverse element law.where is the hardware cost (area)of an execution units of hardwaretypeGMB (5)where is an empirical parameter determined through testing to be equal to three.The global stress is a functionally weighted function of the heuristics,and was constructed through the use of testing and statistical validation.As mentioned above,since MB and C capture information about the starting allocation,they have a large impact on the global stress function in the early stages of the allocation addition phase.The scheduling stress,S,quickly gains dominance as units are added.V.T RANSFORMATIONSFORHBISR D ESIGNTransformations are alterations in the computational struc-ture such that the behavior (the relationship between output and input data)is maintained.Transformations are used exten-sively in several computer science,computer engineering,and CAD areas,most often in compilers [22]and behavioral-level synthesis [23],[24].This section shows how transformations,using specifically tailored optimization techniques,can sig-nificantly reduce the area overhead for designs with BISR requirements.A.Key Ideas and Motivational ExamplesThe basic idea behind using transformations in behavioral-level synthesis for HBISR is to transform the computation according to the needs imposed by the available hardware,for each possible scenario of failed units.The simple example in Fig.2will be used to illustrate this idea.In all the examples in this section,assume that each operation takes one control cycle,and that transformations are done in such a way that important numerical properties (e.g.,numerical stability and overflow control)are maintained in the transformed designs.The validity of the assumptions about the numerical properties of the transformed designs can be verified using fixed-point simulation tools (e.g.,[14]).The assumed available timefor(a)(b)Fig.3.Associativity for HBISR:(a)before and (b)after application of associativity.the first example is two control cycles.The identity shown in Fig.2is used to transform (a)into (b).It is easy to verify that both algorithms calculate the same output for the same set of inputs.All operations lie on the critical path,so it is not possible to reduce BISR overhead using the techniques of Section IV.In this case,however,transformations can help to reduce the overhead.If we consider only implementation Fig.2(a),and assume that any unit can fail,then three adders and two subtracters are needed,since two adders and one subtracter were needed for the non-BISR implementation.However,if we consider both implementations,only two of each type of unit are needed.If the subtracter fails,we can use implementation Fig.2(a)which needs two adders and one subtracter,and when the adder fails we can use implementation Fig.2(b)which needs two subtracters and one adder.In general,there exists a large variety of transformations,each of which reduces a computation in different ways.The transformations to reduce HBISR overhead can be grouped into two classes:1)transformations to increase the resource utilization (and therefore need)of the units of the same type as the failed execution unit and 2)transformations to reduce the number of operations that use the type of unit that failed.While the former strategy is the same as that used during scheduling,the latter is specific to transforma-tions.Transformations in the former group include retim-ing,functional pipelining,associativity,and loop permutation,while those in the latter group include strength reduction (substitution of multiplication with a constant by shifts and additions),constant propagation,dead code elimination and common subexpression elimination.Some transformations can even be used for both strategies simultaneously (e.g.,in-verse element law,distributivity,loop fusion,and loop block-ing).The remainder of this section illustrates how two powerful transformations,associativity and pipelining/retiming,can be used for transformation-based HBISR.Although it is not explicitly stated,it is implied that transformations in the explanatory examples and in the software application are supported by the commutativity transformation.Fig.3shows the application of associativity for HBISR.For this example,the available time is three and assignment and scheduling flexibility does not help to reduce overhead.Notice(a)(b)Fig.4.Retiming for HBISR:rearranging ASAP and ALAP times [23]so that operations which require the faulty units are more uniformly distributed over the available time.TABLE IIF EASIBLE S CHEDULES FOR THE E XAMPLE OF F IG .3.T WO S HIFTERS ,T WO M ULTIPLIERS ,AND T WO A DDERS ARE S UFFICIENT FOR HBISR IMPLEMENTATIONthat shift A on Fig.3(a)and multiplication B on Fig.3(b)are the only operations which are not on the critical path.It can be determined that the minimum non-BISR hardware configuration,for the computation of Fig.3(a)requires two adders,two multipliers,and one ing associativity,only one additional adder and one additional shifter are needed.Table II shows the feasible schedules when three adders,two multipliers,and two shifters are available for various scenarios of unit failures.When a shifter fails,the implementation from Fig.3(a)is used,when a multiplier or adder fail the implementation of Fig.3(b)is used [actually,either (a)or (b)can be used when an adder fails].Next,Fig.4shows how retiming (and similarly pipelining)can be used for HBISR.The available time in this example is two control cycles.The rectangles in the figure denote pipeline delays (states).The operation following the delay uses data produced in the previous iteration by the operation preceding the delay.Therefore,operations which have direct dependencies only with respect to the states,can be scheduled in the first control step.Notice,once again that all the operations reside on the critical path,so there is no flexibility during scheduling.Although retiming cannot,in this case,change the slacks on various operations,it can reshuffle the operation overlaps.This redistribution is done such that operations competing for a faulty unit are no longer bound to happen in the same control step.Analysis of the various schedules shows that three subtracters,two adders,and two shifters are sufficient for HBISR implementation.This results once again in a lower overhead than that achievable using only assignment and scheduling.B.Optimization AlgorithmThe transformation-based HBISR optimization algorithm is given by the following pseudo-code:While(!Done)resolved(i)=NO;k =SelectMostCriticalResource();OptimizeUsingProbalisticSamplingWithFailed Unit(k);if (estimate()indicatesfeasibility)elseresolved(K)=YES;break;AddHardware();AddHardware();Done =TRUE;most promising starting points(TABLE IIIR ESULTSFORA SSIGNMENT AND S CHEDULING -B ASEDHBISRnumber of nodes in the computation).Note that starting points with varying numbers of operations of various types (e.g.,subtraction versus addition)are generated using generalized associativity moves,which include the inverse element law.The second,local optimization phase,uses the basic steepest descent approach to locally maximize these starting points.After each move,the objective function is evaluated,to get an estimate of the final area (execution units,interconnect,and registers)expected from the system.This objective function is composed of three key parts,all of which are strongly correlated to the final area:the critical path,the number of delays,and a measure of the expected resource utilization of each hardware type (the overlap component).During the local phase,the overlap components of the objective function are normalized by the available number of resources of each hardware type.When a unit is in short supply due to failure,the overlap component for the resource is large,and thus the algorithm will transform the graph in such a way that the need for this unit is alleviated.When the probabilistic sampling does not succeed in trans-forming the graph for successful implementation under the given fault scenario,a pipelining-based optimization [24]is used,in which varying number of pipeline states are tried.Both the probabilistic sampling and pipelining algorithmsrunintime.Since the number of required hardware resources is bounded by the number of nodes in the compu-tation,the worst-case running timeis.Experimental studies indicate that the actual run-time is quadratic and was less than 10min for all examples on a Sun SPARCstation-5.Notice that both classes of transformations for HBISR are utilized:1)transformations to increase the chance for high utilization (and therefore reduced need)of the units of the same type as the failed execution unit and 2)transformations to reduce the number of operations of a failed type by trading operations of that type for other operations.VI.E XPERIMENTAL R ESULTSThe HBISR methodology,techniques and proposed algo-rithms were validated on the set of DSP,video,control,and communication examples shown in Table III and de-scribed in [25].Supporting tools from the Hyper behavioral-level synthesis system [14],were used for other synthesis tasks.The table shows all relevant data for the standard and the HBISR synthesis procedures.During the selection of benchmark examples,special attention was devoted to include examples with a variety of computational structures.TABLE IVR ESULTSFORT RANSFORMATION -B ASEDHBISRFor example,note that although the different forms of the eighth-order low-pass IIR Avenhaus filters provide the same functionality,they have drastically different structures and sizes.The average and median HBISR design area overheads were 18.8and 19.4%,respectively.Note also that although the initial implementations of all examples had on average 3.7different types of hardware units,an average of only 2.4additional units were needed for the HBISR designs.Table IV shows results for several examples designed us-ing the transformation-based methods of HBISR design.The average and median area increases are only 8.8and 7.2%,respectively.The examples had an average of four different types of execution units,but an average of only 1.8additional hardware units were needed.While the HBISR techniques increase the yield per wafer (percentage of functional die),the area overhead reduces the number of wafer per die.Productivity (number of functional dies per wafer)takes both of these effects into account.Productivity improvement can thus be used to measure the effectiveness of the HBISR techniques.For these calculations,we used Stapper’s yield formula [26],which calculates the probability thatexactlymodules operate correctly for a given value of the variabilityparameter.This parameter gives an indication of the assumed probability of clustered defects,the most common sources of chip rge valuesof.VII.G ENERALIZING THE HBISR M ETHODOLOGYA.Arbitrary Hardware ModelsIn this section we describe how the HBISR methodology can be used when an arbitrary hardware model is adopted.All that is necessary,actually,is to first propose the HBISR implementation,and then check whether the computation can be correctly implemented on all subsets of the implementa-tion where hardware primitives (execution units,register and interconnects)of the model are removed (assumed faulty and not used)one by one.Note that even in relatively small designs,the total number of execution units,interconnect,and registers is usually high.Therefore,while an arbitrary model offers potential for further hardware reduction and an attractive conceptual generaliza-tion,the number of required schedules and assignments may combinatorially explode.Clearly,there is a tradeoff between potential overhead reduction and tractability of the synthesis algorithms.A moreTABLE VY IELD AND P RODUCTIVITY FOR T RANSFORMATION -B ASED HBISR D ESIGNS ,FOR V ARIOUS V ALUES OF THE V ARIABILITY P ARAMETER .T HE I NITIAL Y IELD IS A SSUMED TO BE10%practical HBISR scheme can be achieved by grouping sev-eral hardware components together and assuming that all of them are either simultaneously faulty or simultaneously functional.This is actually a generalization of the proposed hardware model,where an execution unit,its register files and corresponding interconnects are considered as simultaneously susceptible to a fault.B.Varying Levels of Fault ToleranceUntil now we have restricted our attention to the case when the number of failedmodules,is increased,the improvement in the productivity can give diminishing returns,and can even produce lower productivity [26].An interesting issue for HBISR design is the actual selection of the valueof.Suppose that we have targeted an ASIC designwithnonfunctional units.The number of different schedules and assignments needed is equal to the number of combinationsof,a hybrid ap-proach can provide a good tradeoff between complexity and efficiency.The approach employs an iterative deepening tech-nique,in which proposed allocations are tested for iteratively increasing values of fault toleranceuntil,if we add two instances of each type of executionunit with the corresponding register files and interconnect as required for the assignment only-based BISR,we have a design which is fault tolerant against as many as four faulty units.Another possibility is that we divide all execution types in two subsets.The first subset of execution types is treated using the assignment-only BISR scheme,while the second subset is addressed using the full-fledged behavioral-level synthesis approach.In this scenario,it is apparently advantageous to select more expensive units for the second subset.C.Application-Specific Programmable Processor (ASPP)DesignsThe HBISR approach,as demonstrated,can be used for ASIC yield improvement or low-hardware overhead fault-tolerance against permanent faults.The technique is directly built on the flexibility provided by behavioral-level synthesis during design space exploration.The identification and the techniques for exploiting this flexibility,however,are in them-selves important.Intelligent strategies to use the flexibility of solutions can also be used in the reconfigurable datapath design of application specific programmable processors (ASPP’s).An ASSP design provides an efficient implementation for a set of different applications.This is in contrast to traditional ASIC designs which implement a single application.Minimal hard-ware ASPP implementation is achieved most often by identify-ing a set of implementations for individual applications which are not necessarily minimum hardware implementations,but which are similar in terms of the required hardware resources.Consider,for example,the design of an ASPP to implement the two differentcomputations .Letandandandimplementation,but to find theMinsolution,which。

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