成纤维细胞生长因子的信号通路概要

中国组织工程研究 第20卷 第15期 2016–04–08出版Chinese Journal of Tissue Engineering Research April 8, 2016 Vol.20, No.15ISSN 2095-4344 CN 21-1581/R CODEN: ZLKHAH2255 ·综述·www.CRTER .org苏钰涵，女，1986年生，内蒙古自治区人，汉族，医师，内蒙古医科大学在读硕士。

通讯作者：翁立新，硕士，教授，研究生导师，内蒙古医科大学病理教研室，内蒙古自治区呼和浩特市 010059；内蒙古医科大学附属医院病理科，内蒙古自治区呼和浩特市 010050中图分类号:R318 文献标识码:A 文章编号:2095-4344 (2016)15-02255-10 稿件接受：2016-02-09 成纤维细胞生长因子的信号通路苏钰涵1，杜 华2，牛广明3，王 静4，翁立新1，2(1内蒙古医科大学病理教研室，内蒙古自治区呼和浩特市 010059；内蒙古医科大学附属医院，2病理科，3影像科，内蒙古自治区呼和浩特市 010050；4内蒙古包头市第四医院ICU ，内蒙古自治区包头市 014030)引用本文：苏钰涵，杜华，牛广明，王静，翁立新. 成纤维细胞生长因子的信号通路[J].中国组织工程研究，2016，20(15):2255-2264. DOI: 10.3969/j.issn.2095-4344.2016.15.018 ORCID: 0000-0002-2684-4178(翁立新)文章快速阅读：文题释义：成纤维细胞生长因子：成纤维细胞生长因子可以由内皮细胞、平滑肌细胞和巨噬细胞分泌。

它的作用是促进内皮细胞的游走和平滑肌细胞的增殖，不能使平滑肌细胞游走。

能够促进新血管形成，修复损害的内皮细胞。

成纤维细胞生长因子被认为是病灶形成促进因子，但从修复角度看它也有有利的一面。

成纤维细胞生长因子亚科：分泌的信号成纤维细胞生长因子基于生化功能、序列相似性和进化关系可以分为一些亚科：旁分泌的成纤维细胞生长因子的5亚科，内分泌的成纤维细胞生长因子的一个亚科，和细胞内成纤维细胞生长因子的一个亚科。

摘要背景：在最早的胚胎发育阶段和器官形成期间，成纤维细胞生长因子家族成员的功能是维持祖细胞并介导祖细胞的生长、分化、存活和形态。

成纤维细胞生长因子常在成熟的组织通过重新激活信号通路介导代谢功能、组织修复和再生。

目的：总结并讨论成纤维细胞生长因子信号通路对组织和器官的作用。

方法：由第一作者用计算机检索中国期刊全文数据库(CNKI ：2010至2016年)和Medline 数据库(2000至2016年)，检索词分别为“成纤维细胞生长因子，信号通路”和“Fibroblast growth factor ，signaling pathway ”语言分别设定为中文和英文。

全面阐述成纤维细胞生长因子的信号通路的研究进展。

结果与结论：①共纳入47篇文献；②哺乳动物成纤维细胞生长因子家族的信号是由18个分泌蛋白组成，这18个分泌蛋白与4个信号酪氨酸激酶成纤维细胞生长因子受体相互作用；③成纤维细胞生长因子配体与受体的相互作用是由蛋白质或辅助因子蛋白多糖和胞外结合蛋白来调节的；④活化的成纤维细胞生长因子受体使特定的酪氨酸残基磷酸化，调节与细胞质接头蛋白、RAS-MAPK 、PI3K-AKT 、磷脂酶C γ和STAT 细胞内信号通路的相互作用，4个结构相关的细胞内非信号的成纤维细胞生长因子相互作用来调节电压门控钠离子通道；⑤结果说明，成纤维细胞生长因子存在所有的组织和器官中，成纤维细胞生长因子信号通路异常与发育缺陷、损害对损伤的反应、导致代谢紊乱和癌症发病相关联。

关键词：组织构建；组织工程；成纤维细胞生长因子；成纤维细胞生长因子受体；信号通路；Klotho 细胞；硫酸乙酰肝素蛋白多糖；成纤维细胞生长因子结合蛋白1；细胞外调节蛋白激酶；微小RNA ；肺动脉高压；原发性乳腺肿瘤；内蒙古自治区自然科学基金主题词：组织工程；成纤维细胞生长因子；肿瘤基金资助：内蒙古自治区自然科学基金(NJZY12151)P .O. Box 10002, Shenyang 110180 2256Su Yu-han, Studying for master’s degree, Physician, Department of Pathology, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, ChinaCorresponding author: Weng Li-xin, Master, Professor, Master’s supervisor, Department of Pathology, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China; Department of Pathology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, ChinaThe fibroblast growth factor signaling pathwaySu Yu-han 1, Du Hua 2, Niu Guang-ming 3, Wang Jing 4, Weng Li-xin 1, 2 (1Department of Pathology, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China; 2Department of Pathology, 3Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China; 4Intensive Care Unit, Baotou Fourth Hospital, Baotou 014030, Inner Mongolia Autonomous Region, China)AbstractBACKGROUND: In the earliest stages of embryonic development and organ formation, fibroblast growth factor family members function as mediating the growth, differentiation, survival, and morphology of progenitor cells. Fibroblast growth factor mediates metabolic function, tissue repair and regeneration in mature tissues by reactivation of signal pathways.OBJECTIVE: To summarize and explore the role of the fibroblast growth factor signaling pathway in tissues and organs.METHODS: A computer-based online search was conducted in CNKI and PubMed databases by using the key words of “fibroblast growth factor, signaling pathway” from 2010 to 2016 and 2000 t o 2016, respectively to screen the relevant literatures. The language was limited to both Chinese and English. Research progress in the fibroblast growth factor signaling pathway was summarized.RESULTS AND CONCLUSION: A total of 47 literatures were included. Mammalian fibroblast growth factor family is composed of 18 secreted signal proteins which interact with 4 tyrosine kinase signal fibroblast growth factor receptors. Interaction of fibroblast growth factor ligand with the receptor isregulated by a protein or cofactor binding proteoglycans and extracellular proteins. Activation of fibroblast growth factor receptor mediates interaction with cytoplasmic adapter protein, RAS-MAPK, and PI3K-AKT, phospholipase C γ and STAT signaling pathway by phosphorylation on a specific tyrosine residue. Four structurally related intracellular non-signaling fibroblast growth factors regulate the voltage-gated sodium ion channels by their interactions. Fibroblast growth factors exist in almost all tissues and organs, and developmental defects and abnormal activity of this pathway (destruction of organogenesis) is associated with damage response to injury, metabolic disorders and cancer.Subject headings: Tissue Engineering; Fibroblast Growth Factors; NeoplasmsFunding: the Natural Science Foundation of Inner Mongolia Autonomous Region, China, No. NJZY12151Cite this article: Su YH, Du H, Niu GM, Wang J, Weng LX. The fibroblast growth factor signaling pathway. Zhongguo Zuzhi Gongcheng Yanjiu. 2016;20(15):2255-2264.0 引言 Introduction在最早的胚胎发育阶段和器官形成期间，成纤维细胞生长因子(fibroblast growth factor ，FGF)家族成员的功能是维持祖细胞并介导祖细胞的生长、分化、存活和形态。