Cardioprotection of Shenfu preparata on cardiac myocytes through cytochrome P450 2J3
卡地欧保护性血液透析 FX CorDiax说明书
Cardioprotective HaemodialysisFX CorDiaxDesigned to Dialyse. Built for CardioprotectionS P TThe reduction of risk factors for cardiovascular diseases (CVD) is core to the development of dialysis systems and products at Fresenius Medical Care. Outstanding cardioprotection must be reflected in all levels of product development and application.There have been tremendous improvements in the quality and efficacy of haemodialysis (HD) therapyin recent years. Despite this, cardiovascular diseases (CVD) remain the leading cause of death for patients with end-stage renal disease (ESRD).Cardioprotective Haemodialysis Wide-ranging cardioprotection Protect your PatientServicesOver 30 years of experience in dialysis at your service.Project Planning and ConsultingTraining and EducationTechnical ServicesWater Quality Service (WQS)Medical Information Services ProductsState-of-the-art technologies enable advancedcardioprotective therapies.C orDiax product line:• 5008 CorDiax and 5008S CorDiax• FX CorDiax haemo dia filter• BCM-Body Composition MonitorC lassix product line:• 4008S classix• FX classix dialysersTherapy Data Management System (TDMS)Online Purification Cascade (OPC) Cardioprotective23Moreover, both overall and cardiovascular mortality are markedly greater in ESRD patients than in the general population. This is why we put Cardioprotective Haemo-dialysis on the SPOT. A comprehensive approach that includes services, products and therapies is needed toTherapiesCardioprotective therapies designed by the world market leader in haemodialysis.High-Flux dialysisHighVolume HDF®Advanced Fluid ManagementOutcomesAchieving better outcomes with cardioprotective therapies.Reduced mortality riskFewer cardiovascular complications Optimised use of resourcesachieve the best therapeutic performance – meaning improved clinical outcomes and better quality of life, enhanced control of therapy costs, and simpler, safer handling.HaemodialysisP R ODUCTS45SPOT on:CVD are the largestcauses of death in dialysis patients.High-Flux membranesenhance middlemolecule removal and reduce risk factors.F X CorDiax forenhanced survival and better outcomes.reducing the induction of inflammatory cascades that are central to many aspects of CVD.State-of-the-art technologies such as Fresenius’ Nano Controlled Spinning (NCS™) and INLINE steam sterilisation are the result of continual innovation at Fresenius Medical Care.Advances in material and production technologies have permitted improvements in the wall structure by opening up the support region of the membrane.The Helixone ®plus membrane in the new FX CorDiax dialysers improves the clearance of middle molecules while the loss of essential blood components such as albumin is curtailed. The Helixone ®plus membrane upgrades the FX-class ® dialyser into the CorDiax product line, which provides products for superior cardioprotective therapies.61The authors concluded that “… treating patients with online haemodiafiltration and FX CorDiax 60 instead of FX 60 dialysers results in significantly increased reduction ratios of middle sized molecules without clinically relevant changes in albumin loss.1 Maduell et.al.; ERA-EDTA Congress 2013, May 20, Poster Number MP 390.Removal ratios of FX 60 and FX CorDiax 60 dialysers in post-dilution HDF 1(Q B = 400 mL/min, Q D = 500 mL/min)P RO DUC T SSPOT on:High selectivepermeability for middle moleculesImproved removalof phosphateThe benefits of the advanced fibre design isnot limited to better middle molecule removal. The reduced transmembrane resistance of the FX CorDiax improves the removal of lowm olecular weight substances, e.g. parison of aqueous in-vitro clearances of phosphate(Q B = 300 mL/min, Q D = 500 mL/min). Investigations carried outS P T I N L I N E S t e aS P T S u p e r i oMembranes, such as Helixone ®, which have a high endotoxin retention capacity, protect the patient from inflammation , particularly when ultrapure dialysate is not available.1 SPOT on: Absence of endotoxins minimises inflammation. Reduced cardiovascularrisk factors.Support regionalbumin.I nflammation A naemiaA myloidosisby up to 50%.I mmuneof IFN-γDialysate Inlet PressureBlood OutletPressure26050403020100200190180170160150140β2-microglobulin Q B = 250 mL/min, Q D = 500 mL/min UreaProtect your PatientClinical practice guidelines in Europe recommend the use of High-Flux haemodialysers:Guidelines recommend High-Flux dialysers 1 T attersall J., Nephrol Dial Transplant (2010); 25: 1230–1232.2 M actier R. et al., Renal Association 2009, Renal Association Clinical Practice Guidelines. Haemodialysis membranes(Guidelines 4.1 to 4.5). /clinical/GuidelinesSection/Haemodialysis.aspx. Accessed 2 Dec. 2012.S P T4, 5, 6210 µmS P TC l i n i c a l B e n e fi t s o f t h e R e m o v2SPOT on:I mproved anaemiacontrol.6, 7Reduced inflammation.2 R educed risk of CVDdue to minimising the risk factors.Anaemia management – it was shown thatHigh-Flux membranes improved control of anaemia in EPO hypo-responsive patients while allowing a progressive reduction in the exogenous EPO dose by 25 to 45 %.7 Hence, High-Flux membranes offer the potential to reduce EPO costs.4041Head office: Fresenius Medical Care Deutschland GmbH · 61346 Bad Homburg v. d. H. · Germany Phone: +49 (0) 6172-609-0 · Fax: +49 (0) 6172-609-2191 F 0006435 M T -E N (1.0 B G -p p p p 08.14) © C o p y r i g h t 2012 F r e s e n i u s M e d i c a l C a r e D e u t s c h l a n d G m b H c e r t i f i e d , P E F C /04-31-0000。
血清可溶性生长刺激表达基因2在慢性心力衰竭患者诊断与预后评估中的应用
南昌大学学报(医学版)2021年第 61卷第 1期Journal of Nanchang University(Medical Sciences)2021,Vol.61No.143血清可溶性生长刺激表达基因2在慢性心力衰竭患者诊断与预后评估中的应用刘壮壮，黄宇理(蚌埠医学院第一附属医院心血管内科，安徽蚌埠233000)摘要：目的探讨血清可溶性生长刺激表达基因2蛋白(sST2)在慢性心力衰竭(CHF)患者诊断与预后评估中的应用价值。
方法选取2018年12月至2019年5月蚌埠医学院第一附属医院心血管内科的CHF患者107例；基于NYHA心功能分级将其分为3组，即II级组(19例)、III级组(64例)和N级组(24例)；检测各组血清氨基末端脑钠肽前体(NT-proBNP)和sST2水平、6分钟步行实验(6MWT)、左室射血分数(LVEF)和左室质量指数(LVMI)；分析sST2水平与患者心功能分级、性别、年龄及上述指标的相关性。
结果sST2、6MWT、NT-proBNP水平随着心功能分级的提高而升高(均P<0.01),LVEF随着心功能分级的提高而降低(P<0.01)；sST2水平与患者心功能分级、NT-proBNP、LVMI和6MWT呈正相关(=0.741、r=0.840、r=0.378、r=0.843,均 P<0.01),与LVEF呈负相关(r=-0.657,P<0.01),与性别、年龄无关(r=0.051、r=0.064,P>0.05)。
结论血清sST2水平与CHF 患者的严重程度、预后存在关联，可作为CHF诊断与预后评估的标志物。
关键词：慢性心力衰竭；可溶性生长刺激表达基因2蛋白；诊断；预后中图分类号：R541文献标志码：A文章编号：2095-4727(2021)01-0043-04DOI：10.13764/ki.ncdm.2021.01.009Value of Serum Soluble Growth Stimulation Expressedgene2in Evaluation of Diagnosis andPrognossofChroncHeartFalureLIU Zhuang-zhuang,HUANG Yu-li{Department of Cardiology,the First Affiliated Hospital of BengbuMedical College^Bengbu233000?China)ABSTRACT：Objective Toexplorethevalueofserumsolublegrowthstimulationexpressedgene 2(sST2)in the evaluation of diagnosis and prognosis of chronic heart failure(CHF).Methods A totalof107CHFpatientstreatedintheFirstA f iliated HospitalofBengbu MedicalCo l egefrom December2018to May2019wereselectedinthisstudy.Accordingtothe NYHA classification, the patients were divided into three groups:grade I(n=19),grade I(n=64)and grade IV(n=24).Serum N-terminalpro-brainnatriureticpeptide(NT-ProBNP)andsST2levels,6-minutewalktest6MWT)distance,leftventricularejectionfraction(LVEF),andleftventricular massindex (LVMI)wereexaminedina l patients.Furthermore,therelationshipsofsST2levelsto NYHA classification,gender,age and cardiac function parameters were analyzed.Results The sST2and NT-proBNPlevelsand6MWTdistanceincreasedbuttheLVEFdecreasedwiththeimprovement in NYHA classification(P<0.01).The sST2level was positively correlated with NYHAclassifi-收稿日期:2020-05-06基金项目：蚌埠医学院科研创新计划(Byycxzl823)作者简介：刘壮壮(1994—),男，硕士研究生，住院医师，主要从事心力衰竭的研究。
心肌缺血再灌注损伤中细胞焦亡的研究进展
国际免疫学杂志2021年1月第44卷第1期丨m j hnmUn 〇U a n .2021,V 〇1.44，N 〇. 1• 71 ••综述•心肌缺血再灌注损伤中细胞焦亡的研究进展刘成兴林吉斌李大主华中科技大学同济医学院附属协和医院心内科，武汉43〇〇22 通信作者：李大主，E m a i l :lid a z h u h p @ s o h u . c o m ,电话：139****1110【摘要】细胞焦亡是近年来发现并被证实的一种新的细胞程序性死亡方式，它的特征是依赖半胱氨酸天冬氨酸酶丨（cysteinyl aspartate specific proteinase 1 ,caspase-l)并伴随大量炎症因子的释放。
细胞 焦亡参与了包括感染性疾病在内的多种疾病的病理生理过程作为一种新的调节性细胞死亡方式，近 年来细胞焦亡受到了广泛的关注。
新近研究发现，细胞焦亡也参与了心肌缺血再灌注损伤（myocardialiscliemia reperfusion injury,MIRI)过程，文摩:就M 丨R I 中细胞焦亡的研究进展进行综述.【关键词】细胞焦亡;心肌缺血再灌注损伤;炎性小体基金项目：国家自然科学基金（8〗670404,81700390)D O I ：10. 3760/cma.j. issn. 16734394.2021.01.012Research progress of cell pyroptosis in myocardial ischemia reperfusion injuryLiu Chengxing，Lin Jibin ,Li DazhuDepartment of Cardiology .Union Hospital ,Tongji Medical College ,Haazhong University o f Science and Technology ,Wuhan 430022, ChinaCorresponding author ： Li I)azhu , Email ： lidazkuhp@ sohu. com , Tel ： 13971091 1 10【Abstract 】 Cell pyroptosis is a newly found m o d e of regulated cell death and experimentally verified re-c-ently. I t i s characterized l )y i t s dependence on cysteinyl asparlale specific proteinase 1 (caspase-1 ) and the release of a large numb e r of inflammatory factors. Pyroptosis i s involved in the pathophysiological process of m a n y diseases including infectious diseases. As a new way of regulatory cell death, pyroptosis has attracted extensive attention in recent years. Recent studies have found that i t participates iq the pathological processes of myocardial ischemia reperfusion injury ( M I R I ) . This review summarized the research progress of cell pyroptosis in MIRI.【Key words 】Cell pyroptosis; Myocardial ischemia reperfusion injury; InflammasomeFund program ： National Natural Science Foundation of China( 81670404,81700390)D O I ： 10. 3760/cma. j . issn. 16734394. 2021.01.012上的模式识别受体（pattern recognition receptor ,P R R)识别并诱导相应的炎症反应过程，这些炎症细胞包括单核/巨噬细胞、中性粒细胞和树突状细胞 等夂。
甲哌卡因——精选推荐
甲哌卡因Mepivacaine【其它名称】甲哌酰卡因、卡波卡因、盐酸甲哌卡因、豁酸卡波卡因、Carbocaine、Mepivacaine Hydrochloride、Mepivacainum、Polocaine【临床应用】适用于腹部、四肢及会阴部手术等，常用作浸润麻醉、周围神经阻滞、硬膜外和骶管阻滞等。
【药理】1．药效学本药为酰胺类局部麻醉药，作用与利多卡斟相似或稍强，约为普鲁卡因的2倍。
本药起效迅速，麻醉持续时间持久，且不扩张血管，使用时可不加。
肾上腺素。
2．药动学本药用于硬膜外麻醉时5-15分钟起效。
浸润麻醉时作用持续45-90分钟，硬膜外阻滞时持续6-180分钟。
达峰时间在神经阻滞时为30-60分钟，浸润麻醉时为30分钟。
当血药浓度达到5-lOμg／ml时，对中枢神经及心血管有毒性作用。
总蛋白结合率为75％，可分布到全身各组织中，其中肝、肺、心及脑组织中浓度最高。
在肝脏中迅速代谢后，经肾排泄，主要为代谢产物，原形不足5％-10％。
也可从胆汁中排泄，但最终经肠肝循环从尿中排出。
母体化合物的清除半衰期，成人为1.9～3.2小时，新生儿为8.7-9小时。
【注意事项】1．禁忌症对本药或其它酰胺类麻醉药过敏者(国外资料)。
2．慎用(1)心脏疾病、高血压性血管病(Hypertenswe vascular disease)、低血压。
(2)肝肾疾病。
(以上均为国外资料)3．药物对妊娠的影响本药可通过眙盘影响胎儿。
产科麻醉时如果使用本药，婴儿出生后心动过缓和酸中毒的发生率会增加，国外尚有引起婴儿室性心动过速和死亡的个案报道。
美国FDA对本药的妊娠危险性分级为C级。
4．药物对哺乳的影响本药是否经乳汁分泌尚不明确。
【不良反应】本药引起的全身反应与其它局麻药相似，偶见惊厥、肌肉抽搐、虚脱和低血压，并可能致死。
本药还可使正常心率减慢，有发生Ⅰ度房室传导阻滞及过敏反应的个案报道。
[国外不良反应参考]1．血液系统有研究表明，本药可促发急性血卟啉病。
去细胞化的脂肪组织[发明专利]
![去细胞化的脂肪组织[发明专利]](https://img.taocdn.com/s3/m/fb001114f90f76c660371ab9.png)
专利名称：去细胞化的脂肪组织专利类型：发明专利
发明人：L·E·弗林
申请号：CN201080064286.X 申请日：20101217
公开号：CN102933705A
公开日：
20130213
专利内容由知识产权出版社提供
摘要：本发明提供了一种对脂肪组织去细胞化的方法，包括将脂肪组织在含有一种或者多种的酶的酶解液中进行一次或者多次的培养，还有一次或者多次的溶剂萃取，其中，得到了包括三维结构很好保留的胞外基质的去细胞化脂肪组织。
本发明还提供了一种包括三维结构很好保存的胞外基质的去细胞化脂肪组织，和生物支架、微载体珠，和包括去细胞化脂肪组织的涂层。
申请人：金斯顿女王大学
地址：加拿大安大略省
国籍：CA
代理机构：永新专利商标代理有限公司
代理人：过晓东
更多信息请下载全文后查看。
阿替普酶药物说明
4
cardiogenic shock
适应症l
❖ 1 急性心肌梗死 ❖ ． 对于症状发生6小时以内的患者，采取90分钟加速给
药法(见剂量和用法)。 ❖ ． 对于症状发生6～12小时以内的患者，采取3小时给药
法(见剂量和用法) ❖ 本品已被证实可降低急性心肌梗死患者30天死亡率。 ❖ 2 血流不稳定的急性大面积肺栓塞 ❖ 可能的情况下应借助客观手段明确诊断，如肺血管造影或
3
cardiogenic shock
用法和用量
❖ 应在症状发生后尽快给药。按以下指导剂量给 药。无菌条件下将一小瓶爱通立干粉(10、20、 或50毫克)用注射用水溶解为l毫克／毫升或2毫克 ／毫升的浓度。
❖ 使用爱通立20毫克或50毫克包装中的移液套管完 成上述稀释工作。如果是爱通立10毫克，则使用 注射器。
❖ 与其它溶栓剂相同，个别病例报导发生中枢神经系统事件(如惊厥)，这些事 件通常与发生的缺血性或出血性脑血管事件有关。
7
cardiogenic shock
禁忌症
❖ 本品不可用于有高危出血倾向者，如： ❖ 一 已知出血体质 ❖ 一 口服抗凝血药，如华法令 ❖ ～ 目前或近期有严重的或危险的出血 ❖ 一 已知有颅内出血史或疑有颅内出血一 疑有蛛网膜下腔出血或处于因动脉瘤而导致
10
ca治rsdhioogc疗eknic缺血性脑卒中时的补 充注意事项：
❖ 只有神经专科已经过培训的且有经验的医师才能进行相应治疗。 ❖ 特殊注意事项，收益风险比可能下降： ❖ 与治疗其他适应症相比，本品用于急性缺血性脑卒中治疗时颅内出
血的风险明显增加，因为出血主要发生在梗塞部位。需特别注意以 下情况： ❖ ● 所有禁忌症中包括的事项以及所有可能增加出血风险的情况 ❖ ● 微小的尚无症状的脑动脉瘤 ❖ 预先经阿司匹林治疗且症状发生后没有及时给予本品治疗的患者 可能有更大的脑出血的风险。在这种情况下，本品的用量不得超过 0.9毫克／公斤体重(最大剂量90毫克)。 ❖ 如果症状发生已超过3小时，则患者不得再用本品治疗(参见禁忌 症)．因为不良的收益／风险比值主要基于以下情况： ❖ 随着时间推移，预期的阳性治疗效果会下降 ❖ 预先经阿司匹林治疗的患者其死亡率增加 ❖ 症状性出血的风险增加
魔卡素
魔卡素
魔卡素——存储青春的魔素MAGICSERUM魔丽世嘉护肤专家联合瑞士EPFL大学及瑞士国家科研能力中心(NCCR) ，从纯天然草本植物中研发出震惊美容界之抗衰老元素魔卡素，开启了瑞士抗衰老植物活性元素的先河，突破美容新概念，该项技术已涉及到医学界的各个领域和各个学科，它为美容界的发展带来了革命性的突破，21世纪伴随着分子生物学、生物化学技术的飞速发展，魔卡素类物质具有极强的活性和多样性，是世界生物学界、医学界、药学界研究开发的热点，生物活性魔卡素将在世界范围内引起关注，21世纪将是魔卡素的世纪。
从植物精华中提取的抗衰老元素魔卡素在抗衰老效果得到了全世界的一致认可。
经历反复使用验证，其抗衰老效果让无数的达官贵族、名人及明星实现了延缓青春、绽放美丽的不老传说。
全面解决肌肤问题苏醒疲惫细胞肌肤焕然一新
促进胶原蛋白生成恢复饱满肌
减少表情肌牵拉改善假性皱纹
抗氧化 2%魔卡素可提高抗氧化效果达
美白、击退斑块
涂于皮肤10秒钟即被吸收深层发挥补水作用，用后肌肤好水嫩哦！肌肤对营养
的吸收度会大大的提升
美颜功效：
✧对肌肤吸收功能是一次革命的突破！可提高肌肤吸收护肤品中的有效成份达10
倍以上,有吸收才有效果！
✧能有效供给肌肤细胞能量，促进细胞分裂频率比成熟细胞强
200 倍，全面启动皮肤细胞的分裂和活化；
✧2%魔卡素可提高抗氧化效果达53%.可抑制酪氨酸酶的活性，避免
黑色素生成；
✧亲肤性极佳，涂于皮肤10秒钟即被吸收，可深入肌肤底层，发挥保湿
作用，提高皮肤持久保水能力；
强化自身免疫力，5%魔卡素可提高淡化疤痕效果达12%以上。
细胞培养用青霉素-链霉素产品说明书
细胞培养用青霉素-链霉素产品简介：细胞培养用青霉素-链霉素(Penicillin-Streptomycin for Cell Culture)为粉剂，是最常用的细胞培养用抗生素(即通常所谓的双抗)。
在细胞培养液中推荐的青霉素的工作浓度为100U/ml ，链霉素的工作浓度为0.1mg/ml 。
一个包装的细胞培养用青霉素-链霉素可以配制80L 细胞培养液。
保存条件：室温保存。
4ºC 保存可以使用更长时间。
注意事项：开瓶后需防止受潮。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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使用说明：细胞培养用青霉素-链霉素可以参考如下两种方法之一使用：1. 配制细胞培养液时加入细胞培养用青霉素-链霉素，然后再过滤除菌：配制细胞培养液时按照青霉素的工作浓度为100U/ml ，链霉素的工作浓度为0.1mg/ml 进行配制，配制完成后过滤除菌即可使用。
2. 配制青霉素-链霉素溶液(100X)母液，然后再添加到细胞培养液中：按照青霉素的含量为10KU/ml ，链霉素的含量为10mg/ml ，配制青霉素-链霉素溶液(100X)母液。
过滤除菌后即可按照100倍稀释加入到细胞培养液中使用。
配制的母液可以-20ºC 冻存。
使用本产品的文献：1. Wang PH, Gu ZH, Wan DH, Zhang MY , Weng SP, Yu XQ, He JG. The shrimp NF-κB pathway is activated by white spot syndrome virus (WSSV) 449 to facilitate the expression of WSSV069 (ie1), WSSV303 and WSSV371.PLoS One. 2011;6(9):e24773.2. Xia M, Zhu Y . Signaling pathways of ATP-induced PGE2 release inspinal cord astrocytes are EGFR transactivation-dependent. Glia. 2011 Apr;59(4):664-74. 3. He YH, Song Y , Liao XL, Wang L, Li G, A lima, Li Y , Sun CH. Thecalcium-sensing receptor affects fat accumulation via effects on antilipolytic pathways in adipose tissue of rats fed low-calcium diets. J N utr. 2011 Nov;141(11):1938-46. 4. Liu XY , Wei W, Wang CL, Yue H, Ma D, Zhu C, Ma GH, Du YGApoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity. J. Mater. Chem., 2011,21, 7105-7110. 5. Wang MN, Liu XY , Cao CB, Shi C Synthesis of band-gap tunable Cu –In –S ternary nanocrystals in aqueous solution RSC Adv. 2012 Feb; 7:2666-70. 6. Fan H, Yang L, Fu F, Xu H, Meng Q, Zhu H, Teng L, Yang M, Zhang L,Zhang Z, Liu K Cardio protective effects of salvianolic Acid a on myocardial ischemia-reperfusion injury in vivoand in vitro. Evid Based Complement Alternat Med. 2012;2012:508938. 7. Zhang J, Tang L, Shen L, Zhou S, Duan Z, Xiao L, Cao Y , Mu X, Zha L,Wang H High level of WA VE1 expression is associated with tumor aggressiveness and unfavorableprognosis of epithelial ovarian cancer. Gynecol Oncol. 2012 Oct;127(1):223-30.8. Zhang Y , Zhang Y , Chen M, Yan J, Ye Z, Zhou Y , Tan W, Lang M.Surface properties of amino-functionalized poly(ε-caprolactone) membranes and the improvement of humanmesenchymal stem cell behavior. J Colloid Interface Sci. 2012 Feb 15;368(1):64-9. 9. Jiang M, Gan L, Zhu C, Dong Y , Liu J, Gan Y . Cationic core-shellliponanoparticles for ocular gene delivery. Biomaterials. 2012 Oct; 33(30):7621-30. 10. Chai YY , Wang F, Li YL, Liu K, Xu H. Antioxidant Activities ofStilbenoids from Rheum emodi Wall. Evid Based Complement Alternat Med. 2012;2012:603678. 11. Guo S, Sun X, Cheng J, Xu H, Dan J, Shen J, Zhou Q, Zhang Y , Meng L,Cao W, Tian Y . Apoptosis of THP-1 macrophages induced by protoporphyrin IX-mediated sonodynamic therapy. Int J Nanomedicine. 2013;8:2239-46. 12. Wang S, Luo Y , Zeng S, Luo C, Yang L, Liang Z, Wang Y .Dodecanol-poly(D,L-lactic acid)-b-poly (ethylene glycol)-folate (Dol- PLA-PEG-FA) nanoparticles: evaluation of cell cytotoxicity and selecting capability in vitro. Colloids Surf B Biointerfaces. 2013 Feb 1;102:130-5.碧云天生物技术/Beyotime Biotechnology 订货热线: 400-1683301或800-8283301 订货e-mail :****************** 技术咨询: ***************** 网址: 碧云天网站 微信公众号13.Zhou S, Tang L, Wang H, Dai J, Zhang J, Shen L, Ng SW, Berkowitz RS.Overexpression of c-Abl predicts unfavorable outcome in epithelial ovarian cancer. Gynecol Oncol. 2013 Oct;131(1):69-76.14.Xia M, Zhu Y. FOXO3a Involvement in the Release of TNF-α Stimulatedby ATP in Spinal Cord Astrocytes. J Mol Neurosci. 2013 Nov;51(3):792-804.15.Zhou DH, Wang X, Yang M, Shi X, Huang W, Feng Q. Combination ofLow Concentration of (-)-Epigallocatechin Gallate (EGCG) and Curcumin Strongly Suppresses the Growth of Non-Small Cell Lung Cancer in Vitro and in Vivo through Causing Cell Cycle Arrest. Int J Mol Sci. 2013 Jun 5;14(6):12023-36.16.Jiang XY, Lu DB, Jiang YZ, Zhou LN, Cheng LQ, Chen B.PGC-1αprevents apoptosis in adipose-derived stem cells by reducing reactive oxygen species production in adiabetic microenvironment. Diabetes Res Clin Pract. 2013 Jun;100(3):368-75.17.Zhu Q, Guo T, Xia D, Li X, Zhu C, Li H, Ouyang D, Zhang J, Gan Y.Pluronic F127-modified liposome-containing tacrolimus-cyclodextrin inclusion complexes: improved solubility, cellular uptake and intestinal penetration.J Pharm Pharmacol. 2013 Aug;65(8):1107-17.18.Hu HJ, Lin XL, Liu MH, Fan XJ, Zou WW. Curcumin mediatesreversion of HGF-induced epithelial-mesenchymal transition via inhibition of c-Metexpression in DU145 cells. Oncol Lett. 2016 Feb;11(2):1499-1505.19.Sun C, Feng SB, Cao ZW, Bei JJ, Chen Q, Zhao WB, Xu XJ, Zhou Z, YuZP, Hu HY. Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates PlateletMicrovesicle-Induced Angiogenesis.CELL PHYSIOL BIOCHEM . 2017;41(6):2319-2332.20.Wang J, Zeng H, Li H, Chen T, Wang L, Zhang K, Chen J, Wang R, Li Q,Wang S. MicroRNA-101 Inhibits Growth, Proliferation and Migration and Induces Apoptosis of BreastCancer Cells by Targeting Sex-Determining Region Y-Box 2. CELL PHYSIOL BIOCHEM .2017;43(2):717-732.21.Jiang W, Huang W, Chen Y, Zou M, Peng D, Chen D. HIV-1Transactivator Protein Induces ZO-1 and Neprilysin Dysfunction in Brain Endothelial Cellsvia the Ras Signaling Pathway. Oxid Med Cell Longev . 2017;2017:3160360.22.Li W, Yang Y, Ba Z, Li S, Chen H, Hou X, Ma L, He P, Jiang L, Li L, HeR, Zhang L, Feng D. MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1. Oxid Med Cell Longev .2017;2017:2709053.23.Hu SY, Zhang Y, Zhu PJ, Zhou H, Chen YD. Liraglutide directly protectscardiomyocytes against reperfusion injury possibly via modulation of intracellular calcium homeostasis. J Geriatr Cardiol . 2017 Jan;14(1):57-66.24.Li W, Wang Z, Zha L, Kong D, Liao G, Li H. HMGA2 regulatesepithelial-mesenchymal transition and the acquisition of tumor stem cellproperties through TWIST1 in gastric cancer. Oncol Rep . 2017 Jan;37(1):185-192.25.Tang J, Dong Q. Knockdown of TREM-1 suppresses IL-1β-inducedchondrocyte injury via inhibiting the NF-κB pathway. BIOCHEM BIOPH RES CO . 2017 Jan 22;482(4):1240-1245.26.Yang T, Cheng J, Yang Y, Qi W, Zhao Y, Long H, Xie R, Zhu B. S100BMediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53. Stem Cells . 2017 Feb;35(2):325-336.27.Sun K, Liu F, Wang J, Guo Z, Ji Z, Yao M. The effect of mechanicalstretch stress on the differentiation and apoptosis of human growthplate chondrocytes. IN VITRO CELL DEV-AN . 2017 Feb;53(2):141-148. 28.Peng L, Wang R, Shang J, Xiong Y, Fu Z. Peroxiredoxin 2 is associatedwith colorectal cancer progression and poor survival of patients.ONCOTARGET . 2017 Feb 28;8(9):15057-15070.29.Li L, Guan Q, Dai S, Wei W, Zhang Y. Integrin β1 Increases Stem CellSurvival and Cardiac Function after Myocardial Infarction. Front Pharmacol . 2017 Mar 17;8:135.30.Sui Y, Yao H, Li S, Jin L, Shi P, Li Z, Wang G, Lin S, Wu Y, Li Y, HuangL, Liu Q, Lin X. Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signalingpathway. J MOL MED . 2017 Mar;95(3):311-322.31.Zuo S, Ge H, Li Q, Zhang X, Hu R, Hu S, Liu X, Zhang JH, Chen Y,Feng H. Artesunate Protected Blood-Brain Barrier via Sphingosine 1 Phosphate Receptor1/Phosphatidylinositol 3 Kinase Pathway After Subarachnoid Hemorrhage in Rats. Mol Neurobiol . 2017 Mar;54(2):1213-1228.32.Shen XQ, Geng YM, Liu P, Huang XY, Li SY, Liu CD, Zhou Z, Xu PP.Magnitude-dependent response of osteoblasts regulated by compressive stress. SCI REP-UK . 2017 Mar 20;7:44925.33.Yang R, Wei L, Fu QQ, You H, Yu HR. SOD3 Ameliorates Aβ25-35-Induced Oxidative Damage in SH-SY5Y Cells by Inhibiting the Mitochondrial Pathway. Cell Mol Neurobiol . 2017 Apr;37(3):513-525.34.Lin H, Zhao L, Ma X, Wang BC, Deng XY, Cui M, Chen SF, Shao ZW.Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF. BIOCHEM BIOPH RES CO . 2017 May 20;487(1):181-188.35.Zhang C, Zhou G, Cai C, Li J, Chen F, Xie L, Wang W, Zhang Y, Lai X,Ma L. Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulatingendoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis. Mol Med Rep . 2017 Jun;15(6):3515-3520.36.Zhang EF, Hou ZX, Shao T, Yang WW, Hu B, Wang XX, Zhang ZX,Huang Y, Xiong LZ, Hou LC. Combined administration of a sedative dose sevoflurane and 60% oxygen reduces inflammatoryresponses to sepsis in animals and in human PMBCs. Am J Transl Res . 2017 Jun 15;9(6):3105-3119.37.Shi S, Zhong D, Xiao Y, Wang B, Wang W, Zhang F, Huang H.Syndecan-1 knockdown inhibits glioma cell proliferation and invasion by deregulating a c-src/FAK-associated signaling pathway.ONCOTARGET . 2017 Jun 20;8(25):40922-40934.38.Lin XL, Hu HJ, Liu YB, Hu XM, Fan XJ, Zou WW, Pan YQ, Zhou WQ,Peng MW, Gu CH. Allicin induces the upregulation of ABCA1 expression via PPARγ/LXRαsignaling in THP-1macrophage-derived foam cells. Int J Mol Med . 2017 Jun;39(6):1452-1460.39.Peng K, Yang L, Wang J, Ye F, Dan G, Zhao Y, Cai Y, Cui Z, Ao L, Liu J,Zou Z, Sai Y, Cao J. The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1αRegulatesRotenone-Induced Dopaminergic Neurotoxicity. Mol Neurobiol . 2017 Jul;54(5):3783-3797.40.Liu Z, Zeng W, Wang S, Zhao X, Guo Y, Yu P, Yin X, Liu C, Huang T. Apotential role for the Hippo pathway protein, YAP, in controlling proliferation, cell cycleprogression, and autophagy in BCPAP and KI thyroid papillary carcinoma cells. Am J Transl Res . 2017 Jul 15;9(7):3212-3223.41.Ge Z, Diao H, Yu M, Ji X, Liu Q, Chang X, Wu Q. Connexin 43mediates changes in protein phosphorylation in HK-2 cells during chronic cadmiumexposure. ENVIRON TOXICOL CHEM . 2017 Jul;53:184-190.42.Zhu YM, Gao X, Ni Y, Li W, Kent TA, Qiao SG, Wang C, Xu XX, ZhangHL. Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation afterischemia-reperfusion brain injury.Neuroscience . 2017 Jul 25;356:125-141.43.Wei JL, Fang M, Fu ZX, Zhang SR, Guo JB, Wang R, Lv ZB, Xiong YF.Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectalcancer. ONCOTARGET . 2017 Jul 25;8(30):49318-49328.44.Zhao L, Yang Y, Yin S, Yang T, Luo J, Xie R, Long H, Jiang L, Zhu B.CTCF promotes epithelial ovarian cancer metastasis by broadly controlling the expression of metastasis-associated genes.ONCOTARGET . 2017 Jul 10;8(37):62217-62230.45.Fu QQ, Wei L, Sierra J, Cheng JZ, Moreno-Flores MT, You H, Y u HR.Olfactory Ensheathing Cell-Conditioned Medium Reverts Aβ25-35-Induced Oxidative Damage in SH-SY5Y Cells by Modulating the Mitochondria-Mediated Apoptotic Pathway. Cell Mol Neurobiol . 2017 Aug;37(6):1043-1054.46.Wang T, Liu YP, Wang T, Xu BQ, Xu B. ROS feedback regulates themicroRNA-19-targeted inhibition of the p47phox-mediated LPS-induced inflammatory response. BIOCHEM BIOPH RES CO . 2017 Aug 5;489(4):361-368.47.Zhu Y, Wang L, Y u H, Yin F, Wang Y, Liu H, Jiang L, Qin J. In situgeneration of human brain organoids on a micropillar array. Lab Chip .2017 Aug 22;17(17):2941-2950.48.Liu C, Liu J, Hao Y, Gu Y, Yang Z, Li H, Li R.6,7,3',4'-Tetrahydroxyisoflavone improves the survival of whole-body-irradiated mice viarestoration of hematopoietic function. Int J Radiat Biol . 2017 Aug;93(8):793-802.49.Liao Q, Zhang R, Wang X, Nian W, Ke L, Ouyang W, Zhang Z. Effect offluoride exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosisregulators in PC12 cells. ENVIRON TOXICOL CHEM . 2017 Sep;54:74-79.2 / 3ST488 细胞培养用青霉素-链霉素400-1683301/800-8283301碧云天/Beyotime50.Pan S, Cui Y, Dong X, Zhang T, Xing H. MicroRNA-130b attenuatesdexamethasone-induced increase of lipid accumulation in porcinepreadipocytes by suppressing PPAR-γexpression.ONCOTARGET . 2017 Sep 27;8(50):87928-87943.51.Zhong Y, Jin C, Gan J, Wang X, Shi Z, Xia X, Peng X. Apigeninattenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediatedmitochondrial dysfunction and caspase signal pathway.Toxicon . 2017 Oct;137:106-113.52.Yin L, Huang D, Liu X, Wang Y, Liu J, Liu F, Yu B. Omentin-1 effectson mesenchymal stem cells: proliferation, apoptosis, and angiogenesis in vitro. Stem Cell Res Ther . 2017 Oct 10;8(1):224.53.Tang X, Zha L, Li H, Liao G, Huang Z, Peng X, Wang Z. Upregulationof GNL3 expression promotes colon cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway. Oncol Rep . 2017 Oct;38(4):2023-2032.54.Wu S, Wu F, Jiang Z. Identification of hub genes, key miRNAs andpotential molecular mechanisms of colorectalcancer. Oncol Rep . 2017 Oct;38(4):2043-2050.55.Wang X, Chen G, Huang C, Tu H, Zou J, Yan J. Bone marrow stemcells-derived extracellular matrix is a promising material.ONCOTARGET . 2017 Oct 9;8(58):98336-98347.56.Sun R, Yin L, Zhang S, He L, Cheng X, Wang A, Xia H, Shi H. SimpleLight-Triggered Fluorescent Labeling of Silica Nanoparticles for Cellular ImagingApplications. Chemistry . 2017 Oct 9;23(56):13893-13896. 57.Lin H, Ma X, Wang BC, Zhao L, Liu JX, Pu FF, Hu YQ, Hu HZ, ShaoZW. Edaravone ameliorates compression-induced damage in rat nucleus pulposus cells. Life Sci . 2017 Nov 15;189:76-83.58.Sun G, Sui X, Han D, Gao J, Liu Y, Zhou L. TRIM59 promotes cellproliferation, migration and invasion in human hepatocellular carcinomacells. Pharmazie . 2017 Nov 1;72(11):674-679.59.Zhu Y, Wang L, Yin F, Yu Y, Wang Y, Shepard MJ, Zhuang Z, Qin J.Probing impaired neurogenesis in human brain organoids exposed to alcohol. INTEGR BIOL-UK . 2017 Dec 11;9(12):968-978.60.Shan Y, Wang Y, Li J, Shi H, Fan Y, Yang J, Ren W, Y u X. Biomechanicalproperties and cellular biocompatibility of 3D printed tracheal graft.Bioprocess Biosyst Eng . 2017 Dec;40(12):1813-1823.61.Liu H, Wu B, Ge Y, Huang J, Song S, Wang C, Yao J, Liu K, Li Y, Li Y,Ma X. Phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) as potent focal adhesionkinase (FAK) inhibitors with enhanced activity against pancreatic cancer cell lines. BIOORG MED CHEM LETT . 2017 Dec 15;25(24):6313-6321.62.Lin XL,Liu M,Liu Y,Hu H,Pan Y,Zou W,Fan X,Hu X. Transforminggrowth factor β1 promotes migration and invasion in HepG2 cells: Epithelial-to-mesenchymal transition via JAK/STA T3 signaling. Int J Mol Med. 2018 Jan;41(1):129-136.63.Duan C,Liu Y,Li Y,Chen H,Liu X,Chen X,Y ue J,Zhou X,Yang J.Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR-136-5p and long non-coding RNA HOTAIR in cuprizone-induced demyelination. Biochem Pharmacol. 2018 Sep;155:110-123.64.Zhou X,Li T,Chen Y,Zhang N,Wang P,Liang Y,Long M,Liu H,Mao J,LiuQ,Sun X,Chen H. Mesenchymal stem cell-derived extracellular vesicles promote the in vitro proliferation and migration of breast cancer cells through the activation of the ERK pathway. Int J Oncol. 2019 May;54(5):1843-1852.65.Zheng W,Liu C. The cystathionine γ-lyase/hydrogen sulfide pathwaymediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress. Anatol J Cardiol. 2019 Sep;22(3):102-111.66.Lou K,Huang P,Ma H,Wang X,Xu H,Wang W. Orlistat increases arsenitetolerance in THP-1 derived macrophages through the up-regulation of ABCA1. Drug Chem Toxicol. 2019 Oct 31:1-9.67.Liang S,Wang F,Bao C,Han J,Guo Y,Liu F,Zhang Y. BAG2 amelioratesendoplasmic reticulum stress-induced cell apoptosis in Mycobacterium tuberculosis-infected macrophages through selective autophagy.Autophagy. 2019 Nov 11:1-15.68.Yuan K,Lai C,Wei L,Feng T,Yang Q,Zhang T,Lan T,Yao Y,XiangG,Huang X. The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation. Stem Cells Int. 2019 Dec 4;2019:5310202.Version 2021.11.04碧云天/Beyotime 400-1683301/800-8283301 ST488 细胞培养用青霉素-链霉素 3 / 3。