医药白凡士林执行标准
英国药典 白凡士林
DEFINITIONPurified and wholly or nearly decolorised mixture of semi-solid hydrocarbons, obtained from petroleum. It may contain a suitable antioxidant. White soft paraffin described in this monograph is not suitable for oral use.CHARACTERSAppearanceWhite or almost white, translucent, soft unctuous mass, slightly fluorescent in daylight when melted.SolubilityPractically insoluble in water, soluble in methylene chloride, practically insoluble in alcohol and in glycerol.IDENTIFICATIONFirst identification A, B, D.Second identification A, C, D.A. The drop point is between 35 °C and 70 °C and does not differ by more than 5 °C from the value stated on the label, according to method (2.2.17) with the following modification to fill the cup: heat the substance to be examined at a temperature not exceeding 80 °C, with stirring to ensure uniformity. Warm the metal cup at a temperature not exceeding 80 °C in an oven, remove it from the oven, place on a clean plate or ceramic tile and pour a sufficient quantity of the melted sample into the cup to fill it completely. Allow the filled cup to cool for 30 min on the plate or the ceramic tile and place it in a water bath at 24-26 °C for 30-40 min. Level the surface of the sample with a single stroke of a knife or razor blade, avoiding compression of the sample.B. Infrared absorption spectrophotometry (2.2.24).Comparison Ph. Eur. reference spectrum of white soft paraffin.C. Melt 2 g and when a homogeneous phase is obtained, add 2 ml of water R and 0.2 ml of0.05 M iodine. Shake. Allow to cool. The solid upper layer is violet-pink.D. It complies with the test for appearance (see Tests).TESTSAppearanceThe substance is white. Melt 12 g on a water-bath. The melted mass is not more intensely coloured than a mixture of 1 volume of yellow primary solution and 9 volumes of a 1 per cent m/V solution of hydrochloric acid R(2.2.2, Method II).Acidity or alkalinityTo 10 g add 20 ml of boiling water R and shake vigorously for 1 min. Allow to cool and decant. To 10 ml of the aqueous layer add 0.1 ml of phenolphthalein solution R. The solution is colourless. Not more than 0.5 ml of 0.01 M sodium hydroxide is required to change the colour of the indicator to red.Consistency (2.9.9)60 to 300.Polycyclic aromatic hydrocarbonsMaximum 300 ppm.Use reagents for ultraviolet spectrophotometry. Dissolve 1.0 g in 50 ml of hexane R which has been previously shaken twice with 10 ml of dimethyl sulphoxide R. Transfer the solution to a 125 ml separating funnel with unlubricated ground-glass parts (stopper, stopcock). Add 20 ml of dimethyl sulphoxide R. Shake vigorously for 1 min and allow to stand until 2 clear layers are formed. Transfer the lower layer to a second separating funnel. Repeat the extraction with a further 20 ml of dimethyl sulphoxide R. Shake vigorously the combined lower layers with 20 ml of hexane R for 1 min. Allow to stand until 2 clear layers are formed. Separate the lower layer and dilute to 50.0 ml with dimethyl sulphoxide R. Measure the absorbance (2.2.25) over the range 260 nm to 420 nm using a path length of 4 cm and as compensation liquid the clear lower layer obtained by vigorously shaking 10 ml of dimethyl sulphoxide R with 25 ml of hexane R for 1 min. Prepare a reference solution in dimethyl sulphoxide R containing 6.0 mg of naphthalene R per litre and measure the absorbance of the solution at the maximum at 278 nm using a path length of 4 cm and dimethyl sulphoxide R as compensation liquid. At no wavelength in the range 260 nm to 420 nm does the absorbance of the test solution exceed that of the reference solution at 278 nm.Sulphated ash (2.4.14)Maximum 0.05 per cent, determined on 2.0 g.STORAGEProtected from light.LABELLINGThe label states:—the nominal drop point,—where applicable, the name and concentrationDroping pointethod I(Ph. Eur. method 2.2.14)The melting point determined by the capillary method is the temperature at which the last solid particle of a compact column of a substance in a tube passes into the liquid phase.When prescribed in the monograph, the same apparatus and method are used for the determination of other factors, such as meniscus formation or melting range, that characterise the melting behaviour of a substance.Apparatus The apparatus consists of:—a suitable glass vessel containing a liquid bath (for example, water, liquid paraffin or silicone oil) and fitted with a suitable means of heating,—a suitable means of stirring, ensuring uniformity of temperature within the bath,—a suitable thermometer with graduation at not more than 0.5 °C intervals and provided with an immersion mark. The range of the thermometer is not more than 100 °C,—alkali-free hard-glass capillary tubes of internal diameter 0.9 mm to 1.1 mm with a wall 0.10 mm to 0.15 mm thick and sealed at one end.Method Unless otherwise prescribed, dry the finely powdered substance in vacuo and over anhydrous silica gel R for 24 h. Introduce a sufficient quantity into a capillary tube to give a compact column 4 mm to 6 mm in height. Raise the temperature of the bath to about10 °C below the presumed melting point and then adjust the rate of heating to about 1 °C/min. When the temperature is 5 °C below the presumed melting point, correctly introduce the capillary tube into the instrument. For the apparatus described above, immerse the capillary tube so that the closed end is near the centre of the bulb of the thermometer, the immersion mark of which is at the level of the surface of the liquid. Record the temperature at which the last particle passes into the liquid phase.Calibration of the apparatus The apparatus may be calibrated using melting point reference substances such as those of the World Health Organisation or other appropriate substances.Method II(No Ph. Eur. equivalent method)Apparatus(a) A glass heating vessel of suitable construction and capacity containing one of the following, or another suitable liquid, to a height of not less than 14 cm.(i) A liquid paraffin of sufficiently high boiling point.(ii) A silicone fluid of sufficiently high boiling point.(iii) Water.(b) A suitable stirring device capable of rapidly mixing the liquid.(c) An accurately standardised thermometer suitable for the substance being examined complying with the requirements of British Standard 1365:1990 (Specification for short-range short-stem thermometers) for thermometers designated by one of the following Schedule Marks.(d) Thin-walled capillary glass tubes of hard glass, closed at one end, with a wall thickness of 0.10 to 0.15 mm, at least 12 cm in length and of internal diameter 0.9 to 1.1 mm. The tubes should preferably be kept sealed at both ends and cut as required.Method Dry a small quantity of the finely powdered substance at a temperature considerably below its melting point or at a pressure of 2 kPa over a suitable desiccant, unless otherwise directed. Transfer a portion to a dry capillary tube and pack the powder by tapping on a hard surface so as to form a tightly packed column 4 to 6 mm in height. Heat a suitable liquid in the heating vessel and regulate the rate of rise of temperature, prior to the introduction of the capillary tube, to 3° per minute, unless otherwise directed, stirring constantly. When the temperature reaches 10°below the lowest figure of the range for the substance being tested, adjust the height of the thermometer so that the immersion mark is at the level of the surface of the liquid and insert the capillary tube so that the closed end is near the middle of the bulb of the thermometer. Note the temperature at which the liquefaction of the substance occurs, which is indicated by the formation of a definite meniscus or, for substances that decompose, the temperature at which frothing begins. Correct the observed temperature for any error in the calibration of the thermometer and for the difference, if any, between the temperature of the emergent stem of the thermometer and the temperature of the emergent stem under the conditions of standardisation of the thermometer. The temperature of the emergent stem is determined by placing the bulb of asecond thermometer in contact with the emergent stem at a point approximately midway along the mercury thread in the emergent stem.The correction to be applied is given by the following equation:t c = 0.00016n(t s– t d)wheret c=correction to be added to the observed temperature of the melting point,t s=mean temperature of the emergent column when standardised,t d=mean temperature of the emergent column at the observed melting point,n=number of °C over which the exposed column extends.The corrected temperature is regarded as the melting point of the substance. When the melting point in the monograph is expressed as a range, the melting point of the substance being tested must fall within that range.Method III(Ph. Eur. method 2.2.17)The drop point is the temperature at which the first drop of the melting substance to be examined falls from a cup under defined conditions.Apparatus The apparatus (see Figure 2.2.17.-1) consists of 2 metal sheaths (A) and (B) screwed together. Sheath (A) is fixed to a mercury thermometer. A metal cup (F) is loosely fixed to the lower part of sheath (B) by means of 2 tightening bands (E). Fixed supports (D) 2 mm long determine the exact position of the cup in addition to which they are used to centre the thermometer. A hole (C) pierced in the wall of sheath (B) is used to balance the pressure. The draining surface of the cup must be flat and the edges of the outflow orifice must be at right angles to it. The lower part of the mercury thermometer has the form and size shown in the Figure; it covers a range from 0 °C to 110 °C and on its scale a distance of 1 mm represents a difference of 1 °C. The mercury reservoir of the thermometer has a diameter of 3.5 ±0.2 mm and a height of 6.0 ± 0.3 mm. The apparatus is placed in the axis of a tube about 200 mm long and with an external diameter of about 40 mm. It is fixed to the test-tube by means of a stopper through which the thermometer passes, and is provided with a side groove. The opening of the cup is placed about 15 mm from the bottom of the test-tube. The whole device is immersed in a beaker with a capacity of about 1 litre, filled with water. The bottom of the test-tube is placed about 25 mm from the bottom of the beaker. The water level reaches the upper part of sheath (A). A stirrer is used to ensure that the temperature of the water remains uniform.Method Fill the cup to the brim with the substance to be examined, without melting it, unless otherwise prescribed. Remove the excess substance at the 2 ends of the cup with a spatula. When sheaths (A) and (B) have been assembled press the cup into its housing insheath (B) until it touches the supports. Remove with a spatula the substance pushed out by the thermometer. Place the apparatus in the water-bath as described above. Heat thewater-bath and when the temperature is at about 10 °C below the presumed drop point, adjust the heating rate to about 1 °C/min. Note the temperature at the fall of the first drop. Carry out at least 3 determinations, each time with a fresh sample of the substance. The difference between the readings must not exceed 3 °C. The mean of three readings is the drop point of the substance.Method IV(Ph. Eur. method 2.2.15)For certain substances, the following method is used to determine the melting point (also referred to as slip point and rising melting point when determined by this method).Use glass capillary tubes open at both ends, about 80 mm long, having an external diameter of 1.4 mm to 1.5 mm and an internal diameter of 1.0 mm to 1.2 mm.Introduce into each of 5 capillary tubes a sufficient amount of the substance, previously treated as described, to form in each tube a column about 10 mm high and allow the tubes to stand for the appropriate time and at the prescribed temperature.Unless otherwise prescribed, substances with a waxy consistency are carefully and completely melted on a water-bath before introduction into the capillary tubes. Allow the tubes to stand at 2-8 °C for 2 h.Attach one of the tubes to a thermometer graduated in 0.5 °C so that the substance is close to the bulb of the thermometer. Introduce the thermometer with the attached tube into a beaker so that the distance between the bottom of the beaker and the lower part of the bulb of the thermometer is 1 cm. Fill the beaker with water to a depth of 5 cm. Increase the temperature of the water gradually at a rate of 1 °C/min.The temperature at which the substance begins to rise in the capillary tube is regarded as the melting point.Repeat the operation with the other 4 capillary tubes and calculate the result as the mean of the 5 readings.Method V(Ph. Eur. method 2.2.16)The instantaneous melting point is calculated using the expression:in which t1 is the first temperature and t2 the second temperature read under the conditions stated below.Apparatus The apparatus consists of a metal block resistant to the substance to be examined, of good heat-conducting capacity, such as brass, with a carefully polished plane upper surface. The block is uniformly heated throughout its mass by means of amicro-adjustable gas heater or an electric heating device with fine adjustment. The block has a cylindrical cavity, wide enough to accomodate a thermometer, which should be maintained with the mercury column in the same position during the calibration of the apparatus and the determination of the melting point of the substance to be examined. The cylindrical cavity is parallel to the upper polished surface of the block and about 3 mm from it. The apparatus is calibrated using appropriate substances of known melting point.Method Heat the block at a suitably rapid rate to a temperature about 10 °C below the presumed melting temperature, then adjust the heating rate to about 1 °C/min. At regular intervals drop a few particles of powdered and, where appropriate, dried substance, prepared as for the capillary tube method, onto the block in the vicinity of the thermometer bulb, cleaning the surface after each test. Record the temperature t1 at which the substance melts instantaneously for the first time in contact with the metal. Stop the heating. During cooling drop a few particles of the substance at regular intervals on the block, cleaning the surface after each test. Record the temperature t2 at which the substance ceases to melt instantaneously when it comes in contact with the metalCalibration of the apparatus The apparatus may be calibrated using melting point reference substances such as those of the World Health Organisation or other appropriate substances.ethod III(Ph. Eur. method 2.2.17)The drop point is the temperature at which the first drop of the melting substance to be examined falls from a cup under defined conditions.Apparatus The apparatus (see Figure 2.2.17.-1) consists of 2 metal sheaths (A) and (B) screwed together. Sheath (A) is fixed to a mercury thermometer. A metal cup (F) is loosely fixed to the lower part of sheath (B) by means of 2 tightening bands (E). Fixed supports (D) 2 mm long determine the exact position of the cup in addition to which they are used to centre the thermometer. A hole (C) pierced in the wall of sheath (B) is used to balance the pressure. The draining surface of the cup must be flat and the edges of the outflow orifice must be at right angles to it. The lower part of the mercury thermometer has the form and size shown in the Figure; it covers a range from 0 °C to 110 °C and on its scale a distance of 1 mm represents a difference of 1 °C. The mercury reservoir of the thermometer has a diameter of 3.5 ±0.2 mm and a height of 6.0 ± 0.3 mm. The apparatus is placed in the axis of a tube about 200 mm long and with an external diameter of about 40 mm. It is fixed to the test-tube by means of a stopper through which the thermometer passes, and is provided with a side groove. The opening of the cup is placed about 15 mm from the bottom of the test-tube. The whole device is immersed in a beaker with a capacity of about 1 litre, filled with water. The bottom of the test-tube is placed about 25 mm from the bottom of the beaker. The water level reaches the upper part of sheath (A). A stirrer is used to ensure that the temperature of the water remains uniform.Method Fill the cup to the brim with the substance to be examined, without melting it, unless otherwise prescribed. Remove the excess substance at the 2 ends of the cup with a spatula. When sheaths (A) and (B) have been assembled press the cup into its housing in sheath (B) until it touches the supports. Remove with a spatula the substance pushed out by the thermometer. Place the apparatus in the water-bath as described above. Heat thewater-bath and when the temperature is at about 10 °C below the presumed drop point, adjust the heating rate to about 1 °C/min. Note the temperature at the fall of the first drop. Carry out at least 3 determinations, each time with a fresh sample of the substance. The difference between the readings must not exceed 3 °C. The mean of three readings is the drop point of the substance.Method IV(Ph. Eur. method 2.2.15)For certain substances, the following method is used to determine the melting point (also referred to as slip point and rising melting point when determined by this method).Use glass capillary tubes open at both ends, about 80 mm long, having an external diameter of 1.4 mm to 1.5 mm and an internal diameter of 1.0 mm to 1.2 mm.Introduce into each of 5 capillary tubes a sufficient amount of the substance, previously treated as described, to form in each tube a column about 10 mm high and allow the tubes to stand for the appropriate time and at the prescribed temperature.Unless otherwise prescribed, substances with a waxy consistency are carefully and completely melted on a water-bath before introduction into the capillary tubes. Allow the tubes to stand at 2-8 °C for 2 h.Attach one of the tubes to a thermometer graduated in 0.5 °C so that the substance is close to the bulb of the thermometer. Introduce the thermometer with the attached tube into a beaker so that the distance between the bottom of the beaker and the lower part of the bulb of the thermometer is 1 cm. Fill the beaker with water to a depth of 5 cm. Increase the temperature of the water gradually at a rate of 1 °C/min.The temperature at which the substance begins to rise in the capillary tube is regarded as the melting point.Repeat the operation with the other 4 capillary tubes and calculate the result as the mean of the 5 readings.Method V(Ph. Eur. method 2.2.16)The instantaneous melting point is calculated using the expression:in which t1 is the first temperature and t2 the second temperature read under the conditions stated below.Apparatus The apparatus consists of a metal block resistant to the substance to be examined, of good heat-conducting capacity, such as brass, with a carefully polished plane upper surface. The block is uniformly heated throughout its mass by means of amicro-adjustable gas heater or an electric heating device with fine adjustment. The block has a cylindrical cavity, wide enough to accomodate a thermometer, which should be maintainedwith the mercury column in the same position during the calibration of the apparatus and the determination of the melting point of the substance to be examined. The cylindrical cavity is parallel to the upper polished surface of the block and about 3 mm from it. The apparatus is calibrated using appropriate substances of known melting point.Method Heat the block at a suitably rapid rate to a temperature about 10 °C below the presumed melting temperature, then adjust the heating rate to about 1 °C/min. At regular intervals drop a few particles of powdered and, where appropriate, dried substance, prepared as for the capillary tube method, onto the block in the vicinity of the thermometer bulb, cleaning the surface after each test. Record the temperature t1 at which the substance melts instantaneously for the first time in contact with the metal. Stop the heating. During cooling drop a few particles of the substance at regular intervals on the block, cleaning the surface after each test. Record the temperature t2 at which the substance ceases to melt instantaneously when it comes in contact with the metalCalibration of the apparatus The apparatus may be calibrated using melting point reference substances such as those of the World Health Organisation or other appropriate substances.h. Eur. method 2.2.24)Infrared spectrophotometers are used for recording spectra in the region of 4000-650 cm-1 (2.5-15.4 µm) or in some cases down to 200 cm-1 (50 µm).ApparatusSpectrophotometers for recording spectra consist of a suitable light source, monochromator or interferometer and detector.Fourier transform spectrophotometers use polychromatic radiation and calculate the spectrum in the frequency domain from the original data by Fourier transformation. Spectrophotometers fitted with an optical system capable of producing monochromatic radiation in the measurement region may also be used. Normally the spectrum is given as a function of transmittance, the quotient of the intensity of the transmitted radiation and the incident radiation. It may also be given in absorbance.The absorbance (A) is defined as the logarithm to base 10 of the reciprocal of the transmittance (T):T=I0=intensity of incident radiation,I=intensity of transmitted radiation.Preparation of the sampleFor recording by transmission or absorptionPrepare the substance by one of the following methods.Liquids Examine a liquid either in the form of a film between 2 plates transparent to infrared radiation, or in a cell of suitable path length, also transparent to infrared radiation.Liquids or solids in solution Prepare a solution in a suitable solvent. Choose a concentration and a path length of the cell which give a satisfactory spectrum. Generally, good results are obtained with concentrations of 10-100 g/l for a path length of 0.5-0.1 mm. Absorption due to the solvent is compensated by placing in the reference beam a similar cell containing the solvent used. If an FT-IR instrument is used, the absorption is compensated by recording the spectra for the solvent and the sample successively. The solvent absorbance, corrected by a compensation factor, is subtracted using calculation software.Solids Examine solids dispersed in a suitable liquid (mull) or in a solid (halide disc), as appropriate. If prescribed in the monograph, make a film of a molten mass between 2 plates transparent to infrared radiation.A. MullTriturate a small quantity of the substance to be examined with the minimum quantity of liquid paraffin R or other suitable liquid; 5-10 mg of the substance to be examined is usually sufficient to make an adequate mull using one drop of liquid paraffin R. Compress the mull between 2 plates transparent to infrared radiation.B. DiscTriturate 1-2 mg of the substance to be examined with 300-400 mg, unless otherwise specified, of finely powdered and dried potassium bromide R or potassium chloride R. These quantities are usually sufficient to give a disc of 10-15 mm diameter and a spectrum of suitable intensity. If the substance is a hydrochloride, it is recommended to use potassium chloride R. Carefully grind the mixture, spread it uniformly in a suitable die, and submit it to a pressure of about 800 MPa (8 t·cm-2). For substances that are unstable under normal atmospheric conditions or are hygroscopic, the disc is pressed in vacuo. Several factors may cause the formation of faulty discs, such as insufficient or excessive grinding, humidity or other impurities in the dispersion medium or an insufficient reduction of particle size. A disc is rejected if visual examination shows lack of uniform transparency or when transmittance at about 2000 cm-1 (5 µm) in the absence of a specific absorption band is less than 60 per cent without compensation, unless otherwise prescribed.Gases Examine gases in a cell transparent to infrared radiation and having an optical path length of about 100 mm. Evacuate the cell and fill to the desired pressure through a stopcock or needle valve using a suitable gas transfer line between the cell and the container of the gas to be examined.If necessary adjust the pressure in the cell to atmospheric pressure using a gas transparentto infrared radiation (for example nitrogen R and argon R). To avoid absorption interferences due to water, carbon dioxide or other atmospheric gases, place in the reference beam, if possible, an identical cell that is either evacuated or filled with the gas transparent to infrared radiation.For recording by diffuse reflectanceSolids Triturate a mixture of the substance to be examined with finely powdered and dried potassium bromide R or potassium chloride R. Use a mixture containing approximately 5 per cent of the substance, unless otherwise specified. Grind the mixture, place it in a sample cup and examine the reflectance spectrum.The spectrum of the sample in absorbance mode may be obtained after mathematical treatment of the spectra by the Kubelka-Munk function.For recording by attenuated total reflectionAttenuated total reflection (including multiple reflection) involves light being reflected internally by a transmitting medium, typically for a number of reflections. However, several accessories exist where only one reflection occurs.Prepare the substance as follows. Place the substance to be examined in close contact with an internal reflection element (IRE) such as diamond, germanium, zinc selenide, thallium bromide-thallium iodide (KRS-5) or another suitable material of high refractive index. Ensure close and uniform contact between the substance and the whole crystal surface of the internal reflection element, either by applying pressure or by dissolving the substance in an appropriate solvent, then covering the IRE with the obtained solution and evaporating to dryness. Examine the attenuated total reflectance (ATR) spectrum.Identification using reference substancesPrepare the substance to be examined and the reference substance by the same procedure and record the spectra between 4000-650 cm-1 (2.5-15.4 µm) under the same operational conditions. The transmission minima (absorption maxima) in the spectrum obtained with the substance to be examined correspond in position and relative size to those in the spectrum obtained with the reference substance (CRS).When the spectra recorded in the solid state show differences in the positions of the transmission minima (absorption maxima), treat the substance to be examined and the reference substance in the same manner so that they crystallise or are produced in the same form, or proceed as prescribed in the monograph, then record the spectra.Identification using reference spectraControl of resolution performance For instruments having a monochromator, record the spectrum of a polystyrene film approximately 35 µm in thickness. The difference x (see Figure 2.2.24.-1) between the percentage transmittance at the transmission maximum A at 2870 cm-1 (3.48 µm) and that at the transmission minimum B at 2849.5 cm-1 (3.51 µm) must be greater than 18. The difference y between the percentage transmittance at the transmission maximum C at 1589 cm-1(6.29 µm) and that at the transmission minimum D at 1583 cm-1 (6.32 µm) must be greater than 10.。
凡士林介绍
。涂抹在皮肤上可以保持皮肤湿润，使伤口部位的皮肤 组织保持最佳状态，加速了皮肤自身的修复能力。
三：凡士林本身的味道十分淡，对于对一般润肤产品
所添加的香精、酒精过敏的人非常适合也不过了。
凡士林的应用
11
3 凡士林的应用
普通凡士林 医药凡士林 化妆用凡士林的由来
3
3 凡士林的由来 1
vaseline
石油脂，一种油脂状的石油产品。
4
3 凡士林的由来 1
1859年，罗伯特· 切森堡(Robert Chesebrough)
在石油中提炼出来的副产品
原名为“petroleumjelly”，其中“petroleum”是
石油，而“jelly”则是类似果酱般的胶状物质， 原本为石油探钻的副产品之一。后来命名为凡 士林(Vaseline ['væ slin] ),该名词源于德语“水” （wasser）及希腊语“油”（elaeon）二词合并 而来。
► ► ► ►
能防止溃疡接触口腔内的酸性物质，加速溃疡的愈合。 感冒流鼻水时也可以在鼻子周围的皮肤涂上凡士林，以免擤鼻涕擤多了变 成个红鼻子。 任何小伤口涂点凡士林都有止血的效果，轻微的烫伤也可以涂上凡士林减 缓疼痛。 凡士林的护唇效果也是无可比拟的，它的油脂成份还可以让双唇有水亮亮 的感觉。 在眉毛上涂上一点点凡士林，除了可以顺顺眉毛外，还可以让眉毛的颜色 看起来深一点，省去画眉毛的手续。
剂。不溶于水。
化学稳定性和抗氧化性良好，具有良好
的抗氧化安定性、稳定性和光安定性。
2 凡士林的特性
科学家对凡士林进行了仔细研究，发现凡士林里除了 极具化学惰性的碳氢化合物之外，一无所有。
一：凡士林不亲水，凡士林极具防水性，不易和水混合 二：凡士林没有杀菌能力，但能阻挡来自空气中的细
凡士林检测报告
检测项目
质量指标
检测结果
性质
白色至微近色均匀软膏体，无臭或几乎无臭，与肌肤接触有油腻感，有一定拉丝性。
合格
滴溶点
45～60℃
57℃
杂质吸收度
不得超过0.5
0.029
锥入度
130～230
135
酸碱度
加酚酞无色，加甲基橙不显粉红色
合格
异性有机物
与炽灼残渣
不得超过0.05%
0.021%
凡士林检测报告
详细介绍:
白色至黄棕色允许有矿物油气味，而不允许有煤油气味。。是由石油的残油经硫酸和白土
精制而得，也可以由固体石腊烃和矿物润滑调制而成。凡士林的化学成分长链烷烃。按
其使用要求的不同，可分为普通凡士林、医药凡士林、化妆用凡士林、工业凡士林和电容
器凡士林等。
用途：可作润滑剂、绝缘剂、化妆品、药用油膏、浸润和灌注电容外，当然可用于防锈、和防水剂。
硫化物
不得超过0.00017%
合格
粘度
100℃
11.19
有机酸
加氢氧化钠和酚酞指示液显红色
合格
检测依据
中国药典2005版二部
凡士林说明书
篇一：凡士林安全技术说明书凡士林安全技术说明书第一部分化学品化学品中文名称：凡士林化学品英文名称：vas中文名称2：英文名称2：技术说明书编码： cas no.：8009-03-8分子式：分子量：第二部分成分/组成信息有害物成分含量cas no.：第三部分危险性概述危险性类别：侵入途径：通过食入吸收到体内健康危害：环境危害：燃爆危险：第四部分急救措施皮肤接触：用清水冲洗眼睛接触：先用大量清水冲洗几分钟，然后就医吸入：迅速脱离现场至空气新鲜处食入：饮足量温水，催吐。
就医。
第五部分消防措施危险特性：有害燃烧产物：灭火方法：使用泡沫、干粉、二氧化碳和雾状水第六部分泄露应急处理应急处理：第七部分操作处置与储存操作注意事项：1.刚刚烧伤时最好不用，否则热量散不出去，反而会影响伤口愈合。
2.鼻子阻塞时不要使用，因为凡士林会影响鼻毛对脏空气的清洁能力。
储存注意事项：阴凉处储存避免阳光直射第八部分接触控制/个体防护职业接触限值：中国mac(mg/m3)：前苏联mac(mg/m3)：tlvtn：tlvwn：监测方法：工程控制：禁止明火呼吸系统防护：眼睛防护：戴安全护目镜身体防护：穿普通工作服手防护：戴橡胶手套其他防护：工作时不得进食、饮水或吸烟第九部分理化特性主要成分：蜡膏，不同量的高、中黏度润滑油外观与性状：外观为白色的半透明软膏，有滑腻感，具有一定的拉丝性和粘附性。
擦在皮肤上无嗅味ph：熔点(℃)：36-60沸点(℃)：302相对密度(水=1)：0.9相对蒸气密度(空气=1)：无资料饱和蒸气压(kpa)：20℃时1.3pa燃烧热(kj/mol)：无资料临界温度(℃)：无资料临界压力(mpa)：无资料辛醇/水分配系数的对数值：6闪点(℃)：182-221℃引燃温度(℃)：290爆炸上限%(v/v)：7%爆炸下限%(v/v)：0.9%溶解性：基本不溶于水和乙醇（96%），溶于氯仿、乙醇和溶剂汽油主要用途：适用于配制医用药膏及皮肤保护油膏的原料第十部分稳定性和反应活性稳定性：常温下稳定禁配物：避免接触的条件：聚合危害：分解产物：第十一部分毒理学资料急性毒性：ld50：无资料；lc50：无资料亚急性和慢性毒性：刺激性：致敏性：致突变性：致畸性：致癌性：第十二部分生态学资料生态毒理毒性：生物降解性：非生物降解性：生物富集或生物积累性：其它有害作用：无资料。
白凡士林 质量标准
白凡士林质量标准
白凡士林是一种常见的皮肤护理产品，通常用于保湿和保护皮肤。
它的质量标准通常由国家药品监督管理部门或相关标准化组织
制定和监管。
一般来说，白凡士林的质量标准包括以下几个方面：
1. 成分标准，白凡士林通常由石蜡和凡士林油等成分制成，其
质量标准应包括原材料的纯度、生产工艺、添加剂使用等方面的要求。
2. 产品性能标准，白凡士林的产品性能标准通常包括外观要求、质地、透明度、pH值、水含量等指标，以确保产品符合相关的安全
和使用要求。
3. 医药标准，如果白凡士林被归类为医药产品，那么其质量标
准还需要符合相关的药典要求，包括药物的纯度、稳定性、微生物
限度等指标。
4. 包装标准，白凡士林的包装标准通常包括包装材料的要求、
标签标识、包装规格等，以确保产品在运输和存储过程中不受污染
或损坏。
总的来说，白凡士林作为一种常见的皮肤护理产品，其质量标准应当涵盖原材料、生产工艺、产品性能、医药要求和包装标准等多个方面，以确保产品的质量和安全性。
消费者在购买和使用白凡士林时，可以关注产品的生产许可证、相关认证标识和质量检测报告，以确保产品符合相关的质量标准。
白凡士林成品质量标准
一、目的：
二、范围：
适用于本企业的白凡士林成品的检验及质量控制。
三、职责：
1、品质部：检验员严格按本质量标准检验，认真、及时、准确地填写检验记录，化验室负责人监督检查检验员执行本标准，QA按本标准放行前审核；
2、生产部：严格按本质量标准实施生产。
四、内容：
【批准文号】湘食药辅准字F20050009
【代码】CF001
【规格】165kg/桶(药用钢桶)，20kg/袋（药用低密度聚乙烯袋），2kg/袋（药用低密度聚乙烯袋），500g/瓶（药用高密度聚乙烯瓶）
【类别】药用辅料，软膏基质和润滑剂等。
【贮藏】避光，密闭保存。
【标示】应标明滴点、锥入度的标示范围。
如加入抗氧剂或稳定剂，应标明名称和含量。
【有效期】三年
【注意事项】N/A
五、参考文献：
《中国药典》2020年版四部
六、相关文件：
EK/SMP-QC0005 取样管理规程
EK/SOP-QC3002 白凡士林成品检验操作规程
EK/SOP-QC300201 白凡士林成品检验原始记录
七、相关记录：
N/A。
医药级白凡士林药典备案CP2023
医药级白凡士林药典备案CP2023 医药级白凡士林药典备案CP2023凡士林的作用和用途一、卸妆虽然有专门的卸妆用品，但是万一手边没有的时候，凡士林也可以充当卸妆颂罪产品食用。
将凡士林涂抹在脸上妆容部分进行十秒的按摩，用卸妆巾擦掉，然后再用洗面奶冲洗一遍，也可以将脸洗干净。
二、去黑头脸上的黑头深藏在毛孔之下，凡士林可以溶化脂肪，包裹住脏污，最紧要的是它对肌肤没有刺激。
在黑头初厚涂一层凡士林，用保鲜膜覆盖一层，一刻钟后洗掉。
不过这种深层清洁的方法只能需要偶然用。
三、缓解眼纹年轻女性的眼纹大多是由于干燥缺水而产生的，涂抹乳液后再加一层凡士林，可以加强保湿的效果，过一会儿清洗掉可以更好地削减眼部皱纹。
四、唇膜凡士林可以当作唇膜，将它涂抹在嘴上，用热毛巾敷一会儿。
可以用蜜真唇膏效果超级好清洗的时候一些角质也会随之剥落下来。
长期坚持可以淡化唇上的纹路，涂口红能够更加美丽。
五、保护睫毛常常夹烫睫毛，涂抹睫毛膏的女生简单造成睫毛损伤掉落，卸妆后凡士林涂抹在睫毛根部，睫毛会变得更长更粗，可以保护睫毛。
六、保护指甲凡士林可以让指甲健康生长，手边有倒刺也可以用它软化。
凡士林为指甲加添营养，看起来光泽美丽。
阿司帕坦药用辅料1kg起订湖南符合cp2023药用氨丁三醇1kg起订贵州产cp2023安徽产薄荷素油医药级辅料1L/瓶起订薄荷脑药用级CP2023资质齐全250g/瓶起订苯甲醇500ml起订四川产符合cp2023苯氧乙醇巴斯夫进口500ml起订羟苯甲酯1kg起订药用辅料符合cp2023药用级月桂氮卓酮符合cp2023油溶水溶氮酮二氧化钛药用辅料500g一袋起订25kg符合cp2023 富马酸药用级辅料500g25kgcp2023药用级白蜂蜡cp2023500g/袋起订25kg/袋药用辅料甘露醇500g25kg符合cp2023。
燕京白凡士林(药用)使用说明
燕京白凡士林(药用)【用法用量】静脉滴注，成人一次0.3g，一日2次，使用前先用.%葡萄糖注射液或5%葡萄糖氯化钠注射液或0.9%氯化钠注射液溶解稀释后静脉滴注，滴注时间应大于60分钟。
【注意事项】1.本制剂专供静脉滴注，滴注时间为100ml至少60分钟。
本制剂不宜与其他药物同瓶混合静滴，或在同一根静脉输液管内进行静滴。
2.肾功能减退者应减量或慎用。
肌酐清除率.0～80ml/min正常剂量20～49ml/min首剂0.4g，以后每24小时0.2g10～19ml/min首剂0.4g，以后每48小时0.2g3.有中枢神经系统疾病及癫痫史患者应慎用。
4.喹诺酮类药物尚可引起少见的光毒性反应(发生率【不良反应】用药期间可能出现恶心﹑呕吐﹑腹部不适﹑腹泻﹑食欲不振﹑腹痛﹑腹胀等症状，失眠﹑头晕﹑头痛等神经系统症状;皮疹﹑搔痒﹑红斑及注射部位发红﹑发痒或静脉炎等症状。
亦可出现一过性肝功能异常，如血氨氨基转移酶增高﹑血清总胆红素增加等。
上述发生率在0.1～5%之间。
偶见血中尿素氮升高﹑倦怠﹑发热﹑心悸﹑味觉异常及注射后血管痛等。
一般均能耐受，疗程结束后迅速消失。
【禁忌】对喹诺酮类药物过敏者，妊娠及哺乳期妇女﹑18岁以下患者禁用。
【适应症】本品适用于敏感细菌所引起的下列中﹑重度感染：1﹑呼吸系统感染：急性支气管炎﹑慢性支气管炎急性发作﹑弥漫性细支气管炎﹑支气管扩张合并感染﹑肺炎﹑扁桃体炎(扁桃体肿大)。
2﹑泌尿系统感染：肾盂肾炎﹑复杂性尿路感染等。
3﹑生殖系统感染：急性前列腺炎﹑急性副睾炎﹑宫腔感染﹑子宫附件炎﹑盆腔炎(疑有厌氧菌感染时可合用甲硝唑)。
4﹑皮肤软组织感染：传染性脓疱病﹑蜂窝组织炎﹑淋巴管(结)炎﹑皮下脓肿﹑肛周脓肿等。
5﹑肠道感染：细菌性痢疾﹑感染性肠炎﹑沙门菌属肠炎﹑伤寒及副伤寒。
6﹑败血症﹑粒细胞减少及免疫功能低下患者的各种感染。
7﹑其他感染：乳腺炎﹑外伤﹑烧伤及手术后伤口感染﹑腹腔感染(必要时合用甲硝唑)﹑胆囊炎﹑胆管炎﹑骨与关节感染以及五官科感染等。
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医药白凡士林执行标准项目执行标准(BP-98)
外观白色或淡黄色均匀的软膏状物，无臭无味，与皮肤接触有滑腻感，具有一定的拉丝性
滴熔点℃42—60
锥入度（0.1mm）130—210
稠环芳烃(265-420nm) 不大于 1.08
紫外线吸光度(290nm) 不大于0.5
硫酸盐灰分不大于0.1%
酸碱度BP-98
●已通过国家石蜡检测中心检测，本品为白色软膏状，有一定拉丝性，无臭，
有良好的化学稳定性及滑腻感，适用于作配制医药药膏及皮肤保护油膏的辅料，精密仪器和医疗器械等高级制品的防腐，以及高档化妆品及其他日用品的配料。
●质量标准：符合中国药典2000版要求和英国药典BP-98标准。
医药级白凡士林。