Interaction-induced crossover versus finite-size condensation in a weakly interacting trapp
急性心肌梗死并发心力衰竭的风险预测模型构建及验证
天津医药2023年11月第51卷第11期急性心肌梗死并发心力衰竭的风险预测模型构建及验证马萌雪1，马萍2，徐清斌2△，张世昌2摘要：目的分析急性心肌梗死（AMI）患者发生心力衰竭（HF）的影响因素，并构建风险预测模型。
方法纳入1061例AMI患者，分为模型构建的训练集（786例）和模型验证的测试集（275例）。
利用Lasso回归和多因素Logistic 回归构建AMI患者发生HF的预测模型，并绘制列线图。
采用受试者工作特征（ROC）曲线和校准曲线评价模型的区分度和校准度。
结果利用Lasso回归和多因素Logistic回归筛选出年龄、心率（HR）、ST段偏移、N端脑利钠肽前体（NT-proBNP）、同型半胱氨酸（Hcy）、纤维蛋白原（Fib）、左心室射血分数（LVEF）共7个变量建立模型。
多因素Logistic回归构建预测模型的回归方程为Logit（P）=0.718×ST段偏移+0.042×年龄+0.037×HR+0.000294×NT-proBNP+ 0.040×Hcy+0.220×Fib-5.617×LVEF-5.781。
预测模型训练集的ROC曲线下面积（AUC）为0.846（95%CI：0.817~ 0.875），敏感度为78.50%，特异度为76.60%。
校准曲线显示训练集患者HF的发生率与实际发生率基本相符。
利用测试集对模型进行外部验证，AUC为0.848（95%CI：0.801~0.896），敏感度76.40%，特异度78.00%。
结论AMI患者发生HF与ST段偏移、年龄、入院HR、NT-proBNP、Hcy、Fib、LVEF有关，利用以上变量构建的预测模型具有较高的预测效能，有助于早期识别此类患者。
关键词：心肌梗死；心力衰竭；危险因素；预测；列线图；敏感性与特异性中图分类号：R541文献标志码：A DOI：10.11958/20230055Construction and verification of risk prediction model for acute myocardialinfarction with heart failureMA Mengxue1,MA Ping2,XU Qingbin2△,ZHANG Shichang21Department of Geriatrics and Special Needs,2Department of Cardiovascular,Cardiovascular and Cerebrovascular Disease, the General Hospital of Ningxia Medical University,Yinchuan750000,China△Corresponding Author E-mail:Abstract:Objective To analyze the factors affecting of heart failure(HF)in patients with acute myocardial infarction (AMI),and use the selected indicators to construct a risk prediction model.Methods A total of1061AMI patients were included,and they were divided into the model-constructed training set(786cases)and the test set(275cases).Lasso regression and multiple Logistic regression were used to build a predictive model for HF occurrence in AMI patients,and a Nomogram diagram was drawn.Receiver operating characteristic(ROC)curve and calibration curve were used to evaluate the discrimination and calibration of the model.Results Lasso regression and multiple Logistic regression were used to select7variables to establish the model,including age,heart rate(HR),ST segment deviation,N-telencephalic natriuretic peptide precursor(NT-proBNP),homocysteine(Hcy),fibrinogen(Fib)and left ventricular ejection fraction(LVEF).The regression equation for constructing predictive model by multivariate Logistic regression was Logit(P)=0.718×ST segment 作者单位：1宁夏医科大学总医院心脑血管病医院老年与特需医学科（邮编750000），2心血管内科作者简介：马萌雪（1995），女，硕士，住院医师，主要从事冠心病、心力衰竭的临床研究。
医学课程教学中的情感目标及其达成情况探讨
有利于其尽快地在有限的时间内掌握实习计划的内容,实现角色转变，逐渐适应临床护理工作：6］,能够激励护生开放式探讨问题,有利于培养护生的团队合作精神，同时有利于护生评判性思维的发展%而以案例为基础的学习(CBL)9教学法是从一些具体实例着手，将案例分析法运用到护理教学中，护生沟通技能、解决问题的能力、学习动机都有提高，但实例与临床实践操作仍然存在有不同点，对于实习时间短的护生，这样的方式仍然难以让护生全面地掌握实习计划的内容％如何让护生更快地掌握护理操作技能，巩固基础知识，提高沟通能力，培养全面的临床护理思维能力、观察能力及护理评估能力，本研究通过改变传统的培训模式，制定科学、简明、规范的带教方法，取得了明显效果％3.2“八步系统评估法”具有科学、简明、规范的流程,便于护生掌握有研究指出，护理临床思维是护理人员在临床实践中对患者诊断、护理、预防等思维过程或思维活动(10⑴⑴。
临床思维是一个思维层面的问题，但是体现在能力方面就是一种执行能力。
“八步评估法”引导护生按患者的各个系统进行评估，了解各个系统的功能状况，掌握问题器官及可能出现的问题［12］，明确观察重点，把被动思维变为主动思维，培养护生发现问题、解决问题、完善护理措施、评价护理效果的能力，从而提高自身的临床护理思维能力％由本研究表1可见，观察组临床实践考核得分较对照组显著提高％3.3经过“八步系统评估法”培训的护生，明显提高了收集、归纳、分析的能力同时，护生语言组织、表述及沟通能力也得到很好的锻炼％经过对52份交接班考核表进行统计,“八步系统评估法”对提高护生的交接班质量、缩短交接班时间有明显的效果％3.4培训后的综合效果评价“八步系统评估法”可以减少护生对临床工作的迷茫及恐慌，提高护生对临-教学探索•床工作流程的掌握，工作更有条理，评估方法及观察方法掌握更好，获得更多的护生认可％综上所述，“八步评系统估法”运用科学、简单、系统的流程与临床实践培训相结合，能培养护生临床工作的条理性、系统性，提高护生的识别能力和全面临床思维能力。
RCT 概述(overview)
12
Assignment
Selection
Follow up Measurements and comparison
Intervention
Eligible subjects, who have not presented the outcome of interest
Exp Control
Outcome frequency
Phase 2. To Plan Define hypothesis and variables Select a design
Phase 4. Analysis Interpret findings
Select a sample
Define the intervention and outcome measures Phase 3. Implementation Data collection
5
A concurrent control group is one chosen from the same population as the test group. The concurrent control group is part of the same trial that studies the test treatment, and over the same period of time. Placebo: a “sham” treatment Placebo effect: an inert/sham intervention may cause the patient to believe the treatment will change his/her condition causing the patient to feel their condition has improved. Nhomakorabea
5-HT2AR异源二聚体功能研究进展
网络出版时间：２０２３－０６－１６１１：３４：２７ 网络出版地址：ｈｔｔｐｓ：／／ｋｎｓ．ｃｎｋｉ．ｎｅｔ／ｋｃｍｓ２／ｄｅｔａｉｌ／３４．１０８６．ｒ．２０２３０６１４．１５４９．０６１．ｈｔｍｌ◇综 述◇５ ＨＴ２ＡＲ异源二聚体功能研究进展高 欢１，２，谭 博２，杜广营１，苏瑞斌２（１．烟台大学药学院，山东烟台 ２６４００５；２．军事科学院军事医学研究院毒物药物研究所，抗毒药物与毒理学国家重点实验室，北京 １００８５０）收稿日期：２０２２－１２－１２，修回日期：２０２３－０２－１０基金项目：国家自然科学基金面上项目（Ｎｏ８１７７３７０９）作者简介：高 欢（１９９８－），女，硕士生，研究方向：神经精神药理学，Ｅ ｍａｉｌ：ｇａｏｈｕａｎ０７０８＠１６３．ｃｏｍ；杜广营（１９８０－），男，博士，副教授，硕士生导师，研究方向：新药药理与毒理评价，通信作者，Ｅ ｍａｉｌ：ｄｕｇｕａｎｇｙｉｎｇ＠１２６．ｃｏｍ；苏瑞斌（１９７３－），男，博士，教授，博士生导师，研究方向：神经精神药理学，通信作者，Ｅ ｍａｉｌ：ｒｕｉｂｉｎｓｕ＠１２６．ｃｏｍｄｏｉ：１０．１２３６０／ＣＰＢ２０２２０８００２文献标志码：Ａ文章编号：１００１－１９７８（２０２３）０７－１２０１－０５中国图书分类号：Ｒ ０５；Ｒ３９２．１１；Ｒ７４９摘要：血清素２Ａ受体（５ ＨＴ２ＡＲ）作为致幻剂、抗抑郁药、抗焦虑药和非典型抗精神病药物等许多精神活性药物的作用靶点，受到人们的广泛关注。
５ ＨＴ２ＡＲ属于Ｇ蛋白偶联受体（ＧＰＣＲｓ），与ｍＧｌｕＲ２、Ｄ２Ｒ和ＣＢ１Ｒ等多种ＧＰＣＲｓ形成异源二聚体。
二聚体中的ｍＧｌｕＲ２、Ｄ２Ｒ与ＣＢ１Ｒ影响５ ＨＴ２ＡＲ偶联的信号通路和诱导的动物行为，并且３种受体分别被敲除后，致幻性５ ＨＴ２ＡＲ激动剂诱导产生的甩头反应次数明显降低。
基于５ ＨＴ２ＡＲ／ｍＧｌｕＲ２、５ ＨＴ２ＡＲ／Ｄ２Ｒ和５ ＨＴ２ＡＲ／ＣＢ１Ｒ异源二聚体的重要性，该文将３种受体与５ ＨＴ２ＡＲ形成异源二聚体的发现与功能进行详细综述，为探寻以５ ＨＴ２ＡＲ为靶点的精神活性药物作用机制提供参考。
FAIRCHILD ML4824 说明书
Application Note AN42009 (ML AN33)ML4824 Combo Controller ApplicationsGeneral DescriptionThis Application Note shows the step-by-step process to design a high performance supply. The equations shown in this document can also be used for different output voltages and total power.The complete power supply circuit shown in Figure 6 dem-onstrates the ML4824’s ability to manage high output power while easily complying with international requirements regarding AC line quality. The PFC section provides 380V DC to a dual transistor current-mode forward converter. The out-put of the converter delivers +12V at up to 16 amps. The cir-cuit operates from 80 to 264V AC with both power sections switching at 100kHz.The PFC StagePowering the ML4824The ML4824 is initialized once C 30 is charged to 13Vthrough R 27 and R 30 . PFC switching action now boosts the voltage on C 5 to 380V via T 1’s primary inductance. T 1 then supplies a well regulated 13V for the ML4824 from its sec-ondary winding and full wave rectifier consisting of D 3 , D 4 , C 10 and C 11 . T 1’s primary to secondary turns ratio (N PRI /N SEC ) is 25.5:1. For proper circuit operation, high fre-quency bypassing with low ESR ceramic or film capacitors on V CC and V REF is provided. Orderly PFC operation upon start-up is guaranteed when D 2 quick charges the boostcapacitor to the peak AC line voltage before the boost switchFigure 1. The PFC StageAN42009APPLICATION NOTEAPPLICATION NOTE AN42009AN42009APPLICATION NOTEAPPLICATION NOTE AN42009AN42009APPLICATION NOTEAPPLICATION NOTE AN42009AN42009APPLICATION NOTEAN42009APPLICATION NOTEDISCLAIMERFAIRCHILD SEMICONDUCTOR RESERVES THE RIGHT TO MAKE CHANGES WITHOUT FURTHER NOTICE TO ANY PRODUCTS HEREIN TO IMPROVE RELIABILITY, FUNCTION OR DESIGN. FAIRCHILD DOES NOT ASSUME ANY LIABILITY ARISING OUT OF THE APPLICATION OR USE OF ANY PRODUCT OR CIRCUIT DESCRIBED HEREIN; NEITHER DOES IT CONVEY ANY LICENSE UNDER ITS PATENT RIGHTS, NOR THE RIGHTS OF OTHERS.LIFE SUPPORT POLICYFAIRCHILD’S PRODUCTS ARE NOT AUTHORIZED FOR USE AS CRITICAL COMPONENTS IN LIFE SUPPORT DEVICES OR SYSTEMS WITHOUT THE EXPRESS WRITTEN APPROVAL OF THE PRESIDENT OF FAIRCHILD SEMICONDUCTOR CORPORATION. As used herein:1.Life support devices or systems are devices or systemswhich, (a) are intended for surgical implant into the body, or (b) support or sustain life, or (c) whose failure to perform when properly used in accordance with instructions for use provided in the labeling, can be reasonably expected to result in significant injury to the user.2. A critical component is any component of a life supportdevice or system whose failure to perform can bereasonably expected to cause the failure of the life support device or system, or to affect its safety or effectiveness.。
诱导型多能干细胞在体外三维环境中诱导分化出肠道类器官
诱导型多能干细胞在体外三维环境中诱导分化出肠道类器官李向阳;赵鑫;相小松;郑鹏;惠璜;嵇武【摘要】BACKGROUND: Induced pluripotent stem cells (iPSCs) are a special type of cells with self-renewal and multi-differentiation potential, which can differentiate into intestinal organoids under certain conditions. OBJECTIVE: To explore whether iPSCs can differentiate into intestinal organoids under specific conditions in vitro.METHODS: iPSCs from B6J mice were recovered and cultured for 3 days until clone units covered about 80％ of the culture dish, and then the cells were cultured in the medium containing Activin A for 3 days until the deterministic endoderm formed. Further, the culture medium was replaced by the medium with fibroblast growth factor 4 and Wnt3A for 4 days to differentiate into the spheroids with CDX2+. After that, spheroids were collected and mixed with Matrigel,and then the mixture was dropped into the 4-well plate and cultured with Rspondin1, Noggin, epidermal growth factor, B27 and other growth factors to differentiate into intestinal organoids. Cell morphology was observed, FoxA2 and Sox17 expresson in the deterministic endoderm was detected, and CDX2, Sox9, CGA, MMP7 were measured.RESULTS AND CONCLUSION: iPSCs were cultured with Activin A for 3 days with higher cell fusion, initial differentiation and FoxA2/Sox17 expression (P < 0.05) than those of non-induced iPSCs. Spheroids began to appear at the 3rd day after culture with fibroblast growth factor 4 and WNT3A, and formed a lot at the 4th day. And CDX2 expression in spheroids was significantlyincreased compared with that in the deterministic endoderm (P < 0.05). Organoids gradually formed after 3 days culture, which contained all cell types of intestinal organoids, and expressions of specific markers, Sox9, CGA, MMP7, were significantly higher than those in spheroids (P < 0.05).To conclude, iPSCs can be induced to differentiate into intestinal organoids in three-dimensional niche in vitro.%背景:诱导型多能干细胞是一类特殊的细胞,具有自我更新及多向分化潜力,在一定诱导条件下能够分化为肠道类器官.目的:探究诱导型多能干细胞在体外特定条件下是否可分化出肠道类器官.方法:复苏B6J小鼠18代诱导型多能干细胞,培养3 d克隆单位覆盖培养皿80％左右后,加入含有激活素A的培养基培养3 d,得到确定性内胚层,加入含成纤维细胞生长因子4和Wnt3A的培养基培养4 d,得到中后肠细胞球,将其与Matrigel培养基混合后滴入四孔板形成滴株样生长,在HEPES、Rspondin1、头蛋白、表皮细胞生长因子、B27添加剂等生长因子等共同作用下向肠道类器官分化,期间观察细胞形态变化,检测确定性内胚层FoxA2、Sox17表达,中后肠细胞球特异性标记物CDX2表达,肠道类器官特异性标记物Sox9、CGA、MMP7表达.结果与结论:①诱导型多能干细胞在含有激活素A的培养基培养3 d,细胞初步分化,相互融合,确定性内胚层标记物FoxA2、Sox17表达较诱导型多能干细胞明显升高(P<0.05);②确定性内胚层在含成纤维细胞生长因子4和WNT3A环境下培养第3天开始就有少量中后肠细胞球形成,第4天大量中后肠细胞球形成,中后肠细胞球标记物CDX2较确定性内胚层明显升高(P<0.05);③中后肠细胞球培养3 d后逐渐形成肠道类器官,其特异性标记物Sox9、CGA、MMP7表达明显高于中后肠细胞球(P<0.05);④结果表明,诱导型多能干细胞可在体外三维环境中诱导分化出类肠道器官.【期刊名称】《中国组织工程研究》【年(卷),期】2017(021)025【总页数】5页(P4057-4061)【关键词】干细胞;分化;诱导型多能干细胞;定向分化;体外培养;确定性内胚层;肠道类器官【作者】李向阳;赵鑫;相小松;郑鹏;惠璜;嵇武【作者单位】南京大学医学院附属金陵医院,解放军南京军区南京总医院解放军普通外科研究所,江苏省南京市 210002;南京大学医学院附属金陵医院,解放军南京军区南京总医院解放军普通外科研究所,江苏省南京市 210002;南京大学医学院附属金陵医院,解放军南京军区南京总医院解放军普通外科研究所,江苏省南京市210002;南京大学医学院附属金陵医院,解放军南京军区南京总医院解放军普通外科研究所,江苏省南京市 210002;解放军第二军医大学,上海市 200433;南京大学医学院附属金陵医院,解放军南京军区南京总医院解放军普通外科研究所,江苏省南京市210002【正文语种】中文【中图分类】R394.20 引言 Introduction类器官衍生于多能干细胞或器官前体祖细胞，在细胞成分、特定功能和组织结构等方面与相应的器官高度相似[1]。
VAL-COM-55竞争性交叉参考 波士顿瓷胶到DX ISO系列说明书
VAL-COM-55Competitive Cross Reference Bosch Ceram to DX ISO Series ISSUED: December, 2013Pneumatic DivisionRichland, Michigan 49083ISOMAXCOMPETITIVECROSS REFERENCEWARNING!FAILURE OR IMPROPER SELECTION OR IMPROPER USE OF THE PRODUCTS AND/OR SYSTEMS DESCRIBED HEREIN OR RELATED ITEMS CAN CAUSE DEATH, PERSONAL INJURY AND PROPERTY DAMAGE.This document and other information from Parker Hannifin Corporation, its subsidiaries and authorized distributors provide product and/or system options for further investigation by users having technical expertise. It is important that you analyze all aspects of your application including consequences of any failure, and review the information concerning the product or system in the current product catalog. Due to the variety of operating conditions and applications for these products or systems, the user, through its own analysis and testing, is solely responsible for making the final selection of the products and systems and assuring that all performance, safety and warning requirements of the application are met.The products described herein, including without limitation, product features, specifications, designs, availability and pricing, are subject to change by Parker Hannifin Corporation and its subsidiaries at any time without notice.Offer of SaleThe items described in this document are hereby offered for sale by Parker Hannifin Corporation, its subsidiaries or its authorized distributors. This offer and its acceptance are governed by the provisions stated on the separate page of this document entitled “Offer of Sale”.© Copyright 2013 Parker Hannifin Corporation. All Rights ReservedIntroduction (2)RexRoth Ceram model number index (3)RexRoth Ceram specifications (4)Parker DX ISOMAX model number index (5)Parker DX ISOMAX specifications (6)Parker DX ISOMAX accessories ............................................................................................7-10 Parker DX ISOMAX manifold and sub-base options (11)Crossover list ........................................................................................................................12-15 Dimensions for both Rexroth and DX ISOMAX .....................................................................16-18This Document is to provide a cross reference between the Parker DX ISO Valve and the Bosch Rexroth / Wabco Ceram tm Valve.Bosch Rexroth / Wabco Ceram tm Valve.This Valve is an ISO 5599-1 type valve which means that wherever this valve is mounted, it can be replaced with a competitive ISO 5599-1 a type valve. ISO 5599-1 states that the mounting size and pattern between competitive valves must be interchangeable.ISO 5599-1 does not mandate the type of electrical connection on the solenoid. This is a choice by the manufacturer and a choice by the designer. The choice can be different voltages and electrical connection. The standard cataloged electrical connection on this valve is a 30mm Square 3-Pin – ISO4400, Din 43650A type connection.The traditional spool construction of a pack spool or pack bore is replaced with ceramic technology. The Ceramic Valve Technology gives some unique characters to the valve which will be noted in the DX Valve information. Parker DX Valve.The DX Valve is a 5599-1 type valve. This means the DX Valve can mount to the same mounting pattern asany other 5599-1 type valves. The DX Valve has a standard 30mm Square 3-Pin Connector which meetsthe ISO4400, Din 43650A Standards. The DX valve can replace the Bosch Rexroth / Wabco Ceram tm Valveboth through interchangeability on the same mounting base and by providing the same solenoid voltage and connection type.Depending on the voltage type, it may be necessary to order the valve less solenoids and add solenoid kits.The DX uses ceramic technology. It can be considered for industries where the Bosch Rexroth / Wabco Ceram tm Valve are preferred. For instance, the tire, steel, and wood processing industries prefer ceramic plates versus spools because they are dirt and temperature tolerant. Features of the DX Valve Ceramic include:Excellent reliability:• Long life in excess of 100 million operations*.• Operates with lubricated or non lubricated air.High performances:• Slide valve concept allows high flow / size ratio and short response time due to short slide stroke andlow friction.Switchable selector:• Valves fitted with switchable selector to give internal or external pilot supply• The customer can choose any internal pilot valve and if necessary field convert the valve to an externally piloted valve without any additional kits from Parker.Stable long lasting performances• Low friction switching: minimum wear of the valve member/seal assembly.*See Parker Standard WarrantyRexroth Ceram to DX ISO Series ISO 5599-1Rexroth Ceram to DX ISO Series ISO 5599-1 VAL-COM-55 Model Number IndexRexroth Ceram to DX ISO Series ISO 5599-1 VAL-COM-55Rexroth Ceram to DX ISO Series ISO 5599-1VAL-COM55SpecificationsTemperature Range:Port Sizes:*Solenoid Valves: +5°F to +150°F (-15°C to 66°C)1/4” - 3/8” ISO Size I, 3/8” - 1/2” ISO Size II (-10°F or -12°C operation possible with low temperature solenoid 1/2” - 3/4” ISO Size IIIoperators. Available for 2-position double solenoid and air Working Pressure:Spring return valves.)0 to 150 PSI (0 to 10.3 bar)Air Pilot Valves: -10°F to +175°F (-23°C to 79°C) (Intrinsically Safe versions: Maximum internal pilot valve Media:pressure is 115 PSI or 7.9 bar) Air, either Lubricated or Non-lubricatedVacuum applications: to 24” HgService Life : over 150 million Cycles with or without Line LubricationPilot Pressure:Material :SIZES I & IIBody - Die Cast Anodized Aluminum (Sizes 2 & 3) Die Cast Zinc (size 1) 29 PSI (2.0 bar) minimum, all 2 position valves Valve Elements - Ceramic Slide Plates (AI2O3)44 PSI (3.0 bar) minimum, all 3 position valves 150 PSI (10.3 bar) maximumCombination Manual Override:(Intrinsically Safe versions: Maximum external pilot Explosion-proof models: Non-locking onlypressure is 115 PSI or 7.9 bar) Other models: Locking & Non-Locking sizes I (III : Oct. ‘92 & later)SIZES IIINon-Locking sizes III (Prior to Oct. ‘92) 36 PSI (2.5 bar) minimum, all 2 position valve 44 PSI (3.0 bar) minimum, all 3 position valve Flow:Electrical Data:NEMA 4 Standard*Sub-bases and manifolds available Wide range of accessories, including sandwich speed controls and regulators U.L. and C.S.A. approved solenoids* Not offered with DX3 Valves.† Must be specified when using Sandwich Regulators.-Model Number IndexMaterial SpecificationBody ...................................Polyamide Reinforced Fiberglass Casing - End Plates ................................Anodized Aluminium Seals ...............................................................................Nitrile Screws ..........................................................Zinc Plated Steel Valve Member / Seat ......................Self Lubricating / Ceramic Valve Plate .......................................................................ZincCeramic Technology / Valve Specifications• Subbase Mounted Valves Conforming to ISOStandard 5599/1• High Flow: DX1 (1.15 Cv), DX2 (2.50 Cv), DX3(4.15 Cv)• Air or Solenoid Operation Using CNOMO Solenoids • Can Be Vacuum Operated Air Condition: Filtered to 40µDual Pressure Supply from Exhaust Ports: Y es - Without additional pressure at 12 and 14Dust and Water Protection:IP 65 (According to EN 60529)Mechanical Life:> 100 million operations (Dry air filtered 40 µ, 2 Hz, 6 bar, 20°C)Media:Air or inert gas, filtered 40 µ (Class 5 according to ISO 8573-1), lubricated or non-lubricated Operating Temperature Range: -10°C to 60°C (14°F to 140°F)Data tested with LED and Surge Suppression.Flow Rating (Cv) with Sandwich Regulator##** With 100 PSIG supply, time required to fill from 0 to 90 PSIG and Exhaust from 100 PSIG to 10 PSIG measured from the instant of energizing or de-energizing 24VDC solenoid.Tested per ANSI / (NFPA) T3.21.8Response Time**Single Solenoid 2-Position -Solenoid InformationCodeVoltagePower (W / VA)ACDC60Hz50Hz 19——24 2.8W 49——24 2.7W 53120115—3.7VAOperating PressureVacuum to 145 PSIG (10 bar)Function M.O.P. (PSIG)Internal PilotDX1DX2DX3212-Position, Spring Return 363030512-Poswition, Air Return 303030062-Position 151515113-Position, CE 453636163-Position, APB 453636133-Position, PC4536—External PilotDX1DX2DX3222-Position, Spring Return 363030532-Position, Air Return 303030082-Position 151515123-Position, CE 453636183-Position, APB 453636243-Position, PC4536—Specifications• Remote Air Pilot Operated forhard-to-reach pressure control.• Unregulated Pilot Pressure to valve for consistent valve shifting regardless of pressure adjustment.DX1 - Size 1(Independent Dual Port Regulator Shown)DX2 - Size 2(Independent Dual Port Regulator Shown)Sandwich Regulators FeaturesHow to Configure Sandwich Regulator / Valve Combinations BOLD OPTIONS ARE MOST POPULARBlanking Plate KitsDX2 Shown• Both adjustment screws are located on the 12 end of the unit.• Sandwich Flow Control mounts with its own studs, which means the valve uses standard bolts for mounting.• Sandwich Flow Control is not to be used as a shut off device and is not bubble tight when needles arefully turned down.Sandwich Flow Controls FeaturesRemote Pilot Access Plate KitsSolenoid Kits4“A”, “B” & “G”.Option A & E30mm Square3-Pin ISO 4400, DIN 43650AOption G & QGrommet, 18" or 72" LeadsOption F, H & R1/2" Conduit, 18" or 72" LeadsOption B22mm Rectangular3-Pin DIN, Type B IndustrialSolenoid Information(Solenoids are rated for continuous duty.)Voltage Enclosure “A”Enclosure “B” to “R”CodeACDC PowerconsumptionHolding(amps)PowerconsumptionHolding(amps)60Hz50Hz422422 3.9VA.147.3VA.3145——12 2.6W.21 4.6W.3747*——12 6.2W.52 5.5W.4648*——24 6.8W.29 6.0W.2549——24 2.7W.11 4.8W.2053120110— 4.1VA.04 6.3VA.0557240230— 3.7VA.02 6.4VA.03* Mobile voltages. Solenoid voltage characteristics for all coils located on page D49.* LED with surge suppression.Note: Max ø6.5mm cable size required for connector w/o 6' (2m) cord. IP65 rated when properly installed.3-Pin / 5-Pin Male Automotive Connectors (Use on 22mm Rectangular 3-Pin Solenoid)3-Pin5-PinDescriptionPS2893CP PS2893DP Unlighted PS2893C##PPS2893D##PLighted - VoltageFemale Electrical Connectors / Accessories30mm Square 3-Pin – ISO 4400, DIN 43650A (Use with Enclosure “A”)ConnectorConnector with 6' (2m) CordDescriptionPS2028BPPS2028JCP UnlightedPS203279BP PS2032J79CP*Light – 6-48V . 50/60Hz. 6-48VDC PS203283BP PS2032J83CP*Light – 120V/60Hz PS203283BPN/ALight – 240V/60Hz* LED with surge suppression.Note: Max ø6.5mm cable size required for connector w/o 6' (2m) cord. IP65 rated when properly installed.Engineering Data:Conductors: 2 Poles Plus Ground; Cable Range (Connector Only): 6 to 8mm (0.24 to 0.31 Inch); Contact Spacing: 11mmEngineering Data:Conductors: 2 Poles Plus Ground; Cable Range (Connector Only): 8 to 10mm (0.31 to 0.39 Inch); Contact Spacing: 18mm22mm Rectangular 3-Pin – Type B Industrial (Use with Enclosure “B”)ConnectorConnector with 6' (2m) CordDescriptionPS2429BPPS2429JBP UnlightedPS243079BP PS2430J79BP*Light – 24V60Hz. 24VDC PS243083BP PS2430J83BP*Light – 120V/60Hz PS243087BPN/ALight – 240V/60Hz## — 79 = 6 to 48VAC/VDC83 = 100 to 240VAC/48 to 120 VDCElectrical ConnectorsISO MAX SpecificationsDX1 Series Subbase & ManifoldsSingle subbase Description3/8" NPT3/8" BSPPSide ported base PS4011150CP PS4011160CPManifold bases3/8" NPT3/8" BSPPEnd ported bases PS4011550CP PS4011560CPBottom / End ported bases PS4011650CP PS4011660CP End plate kits NPT port BSPP portDX1 non-collective wiring end plates PS4031010CP PS4031011CPDX2 Series Subbase & ManifoldsSingle subbase Description1/2" NPT1/2" BSPPSide ported base PS4111170CP PS4111180CPManifold bases1/2" NPT1/2" BSPPBottom / End ported bases PS4111670CP PS4111680CPNote: Manifolds include 2 pipe plugsEnd plate kits NPT port BSPP portH2 Non-collective wiring end plates PS4131010CP PS4131011CPDX3 Series Subbase & ManifoldsSingle subbase Description3/4" NPT3/4" BSPPSide ported base PS4211170CP PS4211180CPManifold bases3/4" NPT3/4" BSPPBottom / End ported bases PS4211690CP PS4211600CPNote: Manifolds include 2 pipe plugsEnd plate kits NPT port BSPP portH3 Non-collective wiring end plates PS4231010CP PS4231011CP5 port, 2-position, Single Solenoid, Air Return with 30 mm coil5 port, 2-position, Single Solenoid, Air / Spring Return, Sol. 14Sol. 145 port, 2-position, Double Solenoid, Non-Locking Override5 port, 2-position, All Ports Blocked, Double Solenoid,Sol. 14#12#14CE#12#145 port, 3-position - Exhaust Center, Double Solenoid,* For desired voltage, please order valve less coil and coil kit separate. Other voltage options are also available.#125 port, 2-position, Single Remote Pilot,Air / Spring Return5 port, 3-position, All Ports Blocked,Double Remote Pilot5 port, 2-position, Single Remote Pilot,Air Return5 port, 3-position, Exhaust Center,Double Remote Pilot5 port, 2-position, Double Remote Pilot#12APBCE5 port, 2-position, Single Solenoid Valves with Non-Locking OverrideSeriesA 1E E 1E 2DX17.97(202.5) 4.43(112.5) 4.69(119) 4.53(115)DX28.58(218) 4.86(123.5) 5.12(130) 4.98(126.5)DX39.27(235.5)5.35(136)5.61(142.5)5.47(139)Inches (mm)Size A B C D I 5.12(130.0) 1.57(40.0) 1.89(48.0).31(8.0)II 5.82(147.8) 2.03(51.6) 2.30(58.4).39(10.0)III 7.54(191.5)2.71(68.9)2.59(65.8).41(10.4)SizeE F G H I1.52(38.5) 4.53(115.1) 3.48(88.5) 1.20(30.5)II1.57(40.0) 4.90(124.5) 3.54(90.0).92(23.4)III1.62(41.3)5.23(132.8)4.18(106.2)1.05(25.7)Inches (mm)Sol. 14Sol. 145 port, 2-position, Single Solenoid Valves with Non-Locking OverrideSeriesA 1E E 1E 2DX17.97(202.5) 4.43(112.5) 4.69(119) 4.53(115)DX28.58(218) 4.86(123.5) 5.12(130) 4.98(126.5)DX39.27(235.5)5.35(136)5.61(142.5)5.47(139)Inches (mm)Size A B C D E I 5.12(130.0) 1.57(40.0) 1.89(48.0).31(8.0) 1.52(38.5)II5.82(147.8) 2.03(51.6) 2.30(58.4).39(10.0) 1.57(40.0)III 7.54(191.5)2.71(68.9)2.59(65.8).41(10.4)1.62(41.3)Size F G H J K I4.53(115.1) 3.48(88.5)6.97(177.0) 3.03 (77.0) 1.20 (30.5)II 4.90(124.5) 3.54(90.0)7.09(180.0) 3.15 (80.0).92(23.4)III5.23(132.8)4.18(106.2)8.36(212.3)3.25 (82.6)1.05 (26.7)Inches (mm)Sol. 14#12#14#12#14Series A B C D DX14.72(120) 1.65(42) 1.85(47).20(5)DX25.51(140) 2.13(54) 2.30(58.5).20(5)DX36.69(170)2.68(68)2.80(71).20(5)Inches (mm)5 port, 2 and 3-position, Air Pilot ValvesSize A B C D E I 5.12(130.0) 1.57(40.0) 1.89(48.0).31(8.0) 1.52(38.5)II5.82(147.8) 2.03(51.6) 2.30(58.4).39(10.0) 1.57(40.0)III7.54(191.5)2.71(68.9)2.59(65.8).41(10.4)1.62(41.3)Inches (mm)#12APBCE。
钢铁侠3英语作文
钢铁侠3英语作文In the realm of superhero films, "Iron Man 3" stands as a testament to the power of storytelling and the evolution of the genre. Released in 2013, the film is directed by Shane Black and is the third installment in the Iron Man series, which is part of the larger Marvel Cinematic Universe (MCU). This essay aims to explore the impact of "Iron Man 3" on modern cinema, focusing on its narrative structure, character development, and the broader implications for the superhero genre.Firstly, the narrative structure of "Iron Man 3" deviates from the traditional superhero film formula by incorporating elements of mystery and intrigue. The film begins with a flashback to Tony Stark's past, which is a narrative technique that adds depth to his character and sets the stage for the personal journey he embarks on throughout the movie. This approach to storytelling has since been adopted by other films in the genre, emphasizing the importance of character-driven narratives over simple action sequences.Secondly, the character development in "Iron Man 3" is significant, particularly for the protagonist, Tony Stark. The film delves into his insecurities and vulnerabilities, showing a side of the character that audiences had not seen before. This humanization of a superhero character has resonated with viewers and has influenced subsequent superhero films to focus more on the internal struggles andgrowth of their protagonists.Moreover, "Iron Man 3" also explores the theme of identity and the duality of man versus the suit. The film questions whether it is the man or the technology that makes a hero, a theme that has been revisited in other superhero films and has led to more complex and nuanced portrayals of heroism.In terms of broader implications, "Iron Man 3" has played a crucial role in the expansion of the MCU. It contributed to the interconnectedness of the films within the universe, setting the stage for the epic crossover events like "Avengers: Infinity War" and "Avengers: Endgame." The success of "Iron Man 3" demonstrated the viability of a shared cinematic universe, a concept that has been replicated by other studios and has become a staple in modern cinema.Lastly, the film's box office success and critical acclaim have solidified the superhero genre's place in mainstream cinema. It has shown that superhero films can be both commercially successful and artistically respected, paving the way for more ambitious and diverse superhero stories to be told on the big screen.In conclusion, "Iron Man 3" has left an indelible mark on modern cinema, particularly within the superhero genre. Its innovative narrative techniques, character development, and thematic exploration have set new standards for superhero films. Furthermore, its success within the MCU has demonstrated the potential for interconnected storytellingand has influenced the direction of the genre for years to come.。