Four-loop logarithms in 3d gauge + Higgs theory
Calculation of Gauss Quadrature Rules

by Gene Golub and John Welsch
Presented by Mark Gates
University of Illinois at Urbana-Champaign
March 12, 2007
Mark Gates (UIUC)
Calculation of Gauss Quadrature Rules
March 12, 2007
7 / 16
Quadrature nodes
(From previous slide) xp(x) = T p(x) + (1/an )pn (x)en Quadrature nodes are roots xi of pn (x) xi p(xi ) = T p(xi ) + 0 for i = 1, . . . , n
1/2
=
1/2
1 2 1 4
1/2
1 =√ , 2 = 1 2 for i > 1
1/2
=
Mark Gates (UIUC)
Calculation of Gauss Quadrature Rules
March 12, 2007
11 / 16
Example
Yields tridiagonal matrix 0 √ T = 1/ 2 0 with eigenvalues and eigenvectors 0.57735 Q = −0.70711 0.40825 0.57735 0 −0.8165 0.57735 0.70711 0.40825 √ 1/ 2 0 0 1/2 1 /2 0
JosephWang等人Nature子刊:连续监测多种生物标志物的可穿戴传感器

JosephWang等人Nature子刊:连续监测多种生物标志物的可穿戴传感器研究内容基于微针的可穿戴传感器阵列用于监测组织液中的多种生物标志物,缺乏系统集成和稳健分析性能的证据。
加州大学圣地亚哥分校Joseph Wang教授和Patrick P. Mercier教授合作报道了一种小型化、完全集成、无线操作的可穿戴微针阵列传感器,用于连续监测自由行为的人组织液(ISF中的生物标志物(乳酸和葡萄糖,或酒精和葡萄糖)。
其结果与相应的金标准(血液或呼吸)测量结果密切相关。
相关工作以“An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid”为题发表在国际著名期刊Nature Biomedical Engineering上。
研究要点要点1. 一个完全集成的微针传感器系统由多个传感探头阵列和定制电子器件组成。
集成系统由9个不同的子组件组成,这些子组件被组装成两个主要组件——“一次性传感器”和“可重复使用的电子产品”,以便根据其功能寿命方便地更换低成本的一次性传感器组件。
要点2. 可穿戴系统不断收集丰富的分子数据,以便更好地了解身体对日常活动的反应。
ISF生物标志物(葡萄糖、乳酸和/或酒精)的实时监测可以单独(单个分析物)和同时(葡萄糖-酒精和葡萄糖-乳酸)进行,其结果与相应的金标准(血液或呼吸)测量结果密切相关。
要点3. 该设备与定制的智能手机应用程序一起工作,用于数据捕获和可视化,包括可重复使用的电子器件和一次性微针阵列,并通过先进的微加工进行系统集成、低成本制造、更容易组装、生物相容性、无痛皮肤穿透和增强灵敏度。
通过实验室测试及验证数据表明,该技术可同时实时监测组织液中几种生物标志物,且具有很强的稳健性和实用性。
研究图文图1. 基于微针的多路复用可穿戴传感器系统及其子组件的插图。
物理化学基本概念

物理化学概念及术语A B C D E F G H I J K L M N O P Q R S T U V W X Y Z概念及术语 (16)BET公式BET formula (16)DLVO理论 DLVO theory (16)HLB法hydrophile-lipophile balance method (16)pVT性质 pVT property (16)ζ电势 zeta potential (16)阿伏加德罗常数 Avogadro’number (16)阿伏加德罗定律 Avogadro law (16)阿累尼乌斯电离理论Arrhenius ionization theory (16)阿累尼乌斯方程Arrhenius equation (17)阿累尼乌斯活化能 Arrhenius activation energy (17)阿马格定律 Amagat law (17)艾林方程 Erying equation (17)爱因斯坦光化当量定律 Einstein’s law of photochemical equivalence (17)爱因斯坦-斯托克斯方程 Einstein-Stokes equation (17)安托万常数 Antoine constant (17)安托万方程 Antoine equation (17)盎萨格电导理论Onsager’s theory of conductance (17)半电池half cell (17)半衰期half time period (18)饱和液体 saturated liquids (18)饱和蒸气 saturated vapor (18)饱和吸附量 saturated extent of adsorption (18)饱和蒸气压 saturated vapor pressure (18)爆炸界限 explosion limits (18)比表面功 specific surface work (18)比表面吉布斯函数 specific surface Gibbs function (18)比浓粘度 reduced viscosity (18)标准电动势 standard electromotive force (18)标准电极电势 standard electrode potential (18)标准摩尔反应焓 standard molar reaction enthalpy (18)标准摩尔反应吉布斯函数 standard Gibbs function of molar reaction (18)标准摩尔反应熵 standard molar reaction entropy (19)标准摩尔焓函数 standard molar enthalpy function (19)标准摩尔吉布斯自由能函数 standard molar Gibbs free energy function (19)标准摩尔燃烧焓 standard molar combustion enthalpy (19)标准摩尔熵 standard molar entropy (19)标准摩尔生成焓 standard molar formation enthalpy (19)标准摩尔生成吉布斯函数 standard molar formation Gibbs function (19)标准平衡常数 standard equilibrium constant (19)标准氢电极 standard hydrogen electrode (19)标准态 standard state (19)标准熵 standard entropy (20)标准压力 standard pressure (20)标准状况 standard condition (20)表观活化能apparent activation energy (20)表观摩尔质量 apparent molecular weight (20)表观迁移数apparent transference number (20)表面 surfaces (20)表面过程控制 surface process control (20)表面活性剂surfactants (21)表面吸附量 surface excess (21)表面张力 surface tension (21)表面质量作用定律 surface mass action law (21)波义尔定律 Boyle law (21)波义尔温度 Boyle temperature (21)波义尔点 Boyle point (21)玻尔兹曼常数 Boltzmann constant (22)玻尔兹曼分布 Boltzmann distribution (22)玻尔兹曼公式 Boltzmann formula (22)玻尔兹曼熵定理 Boltzmann entropy theorem (22)泊Poise (22)不可逆过程 irreversible process (22)不可逆过程热力学thermodynamics of irreversible processes (22)不可逆相变化 irreversible phase change (22)布朗运动 brownian movement (22)查理定律 Charle’s law (22)产率 yield (23)敞开系统 open system (23)超电势 over potential (23)沉降 sedimentation (23)沉降电势 sedimentation potential (23)沉降平衡 sedimentation equilibrium (23)触变 thixotropy (23)粗分散系统 thick disperse system (23)催化剂 catalyst (23)单分子层吸附理论 mono molecule layer adsorption (23)单分子反应 unimolecular reaction (23)单链反应 straight chain reactions (24)弹式量热计 bomb calorimeter (24)道尔顿定律 Dalton law (24)道尔顿分压定律 Dalton partial pressure law (24)德拜和法尔肯哈根效应Debye and Falkenhagen effect (24)德拜立方公式 Debye cubic formula (24)德拜-休克尔极限公式 Debye-Huckel’s limiting equation (24)等焓过程 isenthalpic process (24)等焓线isenthalpic line (24)等几率定理 theorem of equal probability (24)等温等容位Helmholtz free energy (25)等温等压位Gibbs free energy (25)等温方程 equation at constant temperature (25)低共熔点 eutectic point (25)低共熔混合物 eutectic mixture (25)低会溶点 lower consolute point (25)低熔冰盐合晶 cryohydric (26)第二类永动机 perpetual machine of the second kind (26)第三定律熵 Third-Law entropy (26)第一类永动机 perpetual machine of the first kind (26)缔合化学吸附 association chemical adsorption (26)电池常数 cell constant (26)电池电动势 electromotive force of cells (26)电池反应 cell reaction (27)电导 conductance (27)电导率 conductivity (27)电动势的温度系数 temperature coefficient of electromotive force (27)电动电势 zeta potential (27)电功electric work (27)电化学 electrochemistry (27)电化学极化 electrochemical polarization (27)电极电势 electrode potential (27)电极反应 reactions on the electrode (27)电极种类 type of electrodes (27)电解池 electrolytic cell (28)电量计 coulometer (28)电流效率current efficiency (28)电迁移 electro migration (28)电迁移率 electromobility (28)电渗 electroosmosis (28)电渗析 electrodialysis (28)电泳 electrophoresis (28)丁达尔效应 Dyndall effect (28)定容摩尔热容 molar heat capacity under constant volume (28)定容温度计 Constant voIume thermometer (28)定压摩尔热容 molar heat capacity under constant pressure (29)定压温度计 constant pressure thermometer (29)定域子系统 localized particle system (29)动力学方程kinetic equations (29)动力学控制 kinetics control (29)独立子系统 independent particle system (29)对比摩尔体积 reduced mole volume (29)对比体积 reduced volume (29)对比温度 reduced temperature (29)对比压力 reduced pressure (29)对称数 symmetry number (29)对行反应reversible reactions (29)对应状态原理 principle of corresponding state (29)多方过程polytropic process (30)多分子层吸附理论 adsorption theory of multi-molecular layers (30)二级反应second order reaction (30)二级相变second order phase change (30)法拉第常数 faraday constant (31)法拉第定律 Faraday’s law (31)反电动势back E.M.F. (31)反渗透 reverse osmosis (31)反应分子数 molecularity (31)反应级数 reaction orders (31)反应进度 extent of reaction (32)反应热heat of reaction (32)反应速率rate of reaction (32)反应速率常数 constant of reaction rate (32)范德华常数 van der Waals constant (32)范德华方程 van der Waals equation (32)范德华力 van der Waals force (32)范德华气体 van der Waals gases (32)范特霍夫方程 van’t Hoff equation (32)范特霍夫规则 van’t Hoff rule (33)范特霍夫渗透压公式 van’t Hoff equation of osmotic pressure (33)非基元反应 non-elementary reactions (33)非体积功 non-volume work (33)非依时计量学反应 time independent stoichiometric reactions (33)菲克扩散第一定律 Fick’s first law of diffusion (33)沸点 boiling point (33)沸点升高 elevation of boiling point (33)费米-狄拉克统计Fermi-Dirac statistics (33)分布 distribution (33)分布数 distribution numbers (34)分解电压 decomposition voltage (34)分配定律 distribution law (34)分散系统 disperse system (34)分散相 dispersion phase (34)分体积 partial volume (34)分体积定律 partial volume law (34)分压 partial pressure (34)分压定律 partial pressure law (34)分子反应力学 mechanics of molecular reactions (34)分子间力 intermolecular force (34)分子蒸馏molecular distillation (35)封闭系统 closed system (35)附加压力 excess pressure (35)弗罗因德利希吸附经验式 Freundlich empirical formula of adsorption (35)负极 negative pole (35)负吸附 negative adsorption (35)复合反应composite reaction (35)盖.吕萨克定律 Gay-Lussac law (35)盖斯定律 Hess law (35)甘汞电极 calomel electrode (35)感胶离子序 lyotropic series (35)杠杆规则 lever rule (35)高分子溶液 macromolecular solution (36)高会溶点 upper consolute point (36)隔离法the isolation method (36)格罗塞斯-德雷珀定律 Grotthus-Draoer’s law (36)隔离系统 isolated system (37)根均方速率 root-mean-square speed (37)功 work (37)功函work content (37)共轭溶液 conjugate solution (37)共沸温度 azeotropic temperature (37)构型熵configurational entropy (37)孤立系统 isolated system (37)固溶胶 solid sol (37)固态混合物 solid solution (38)固相线 solid phase line (38)光反应 photoreaction (38)光化学第二定律 the second law of actinochemistry (38)光化学第一定律 the first law of actinochemistry (38)光敏反应 photosensitized reactions (38)光谱熵 spectrum entropy (38)广度性质 extensive property (38)广延量 extensive quantity (38)广延性质 extensive property (38)规定熵 stipulated entropy (38)过饱和溶液 oversaturated solution (38)过饱和蒸气 oversaturated vapor (38)过程 process (39)过渡状态理论 transition state theory (39)过冷水 super-cooled water (39)过冷液体 overcooled liquid (39)过热液体 overheated liquid (39)亥姆霍兹函数 Helmholtz function (39)亥姆霍兹函数判据 Helmholtz function criterion (39)亥姆霍兹自由能 Helmholtz free energy (39)亥氏函数 Helmholtz function (39)焓 enthalpy (39)亨利常数 Henry constant (39)亨利定律 Henry law (39)恒沸混合物 constant boiling mixture (40)恒容摩尔热容 molar heat capacity at constant volume (40)恒容热 heat at constant volume (40)恒外压 constant external pressure (40)恒压摩尔热容 molar heat capacity at constant pressure (40)恒压热 heat at constant pressure (40)化学动力学chemical kinetics (40)化学反应计量式 stoichiometric equation of chemical reaction (40)化学反应计量系数 stoichiometric coefficient of chemical reaction (40)化学反应进度 extent of chemical reaction (41)化学亲合势 chemical affinity (41)化学热力学chemical thermodynamics (41)化学势 chemical potential (41)化学势判据 chemical potential criterion (41)化学吸附 chemisorptions (41)环境 environment (41)环境熵变 entropy change in environment (41)挥发度volatility (41)混合熵 entropy of mixing (42)混合物 mixture (42)活度 activity (42)活化控制 activation control (42)活化络合物理论 activated complex theory (42)活化能activation energy (43)霍根-华森图 Hougen-Watson Chart (43)基态能级 energy level at ground state (43)基希霍夫公式 Kirchhoff formula (43)基元反应elementary reactions (43)积分溶解热 integration heat of dissolution (43)吉布斯-杜亥姆方程 Gibbs-Duhem equation (43)吉布斯-亥姆霍兹方程 Gibbs-Helmhotz equation (43)吉布斯函数 Gibbs function (43)吉布斯函数判据 Gibbs function criterion (44)吉布斯吸附公式Gibbs adsorption formula (44)吉布斯自由能 Gibbs free energy (44)吉氏函数 Gibbs function (44)极化电极电势 polarization potential of electrode (44)极化曲线 polarization curves (44)极化作用 polarization (44)极限摩尔电导率 limiting molar conductivity (44)几率因子 steric factor (44)计量式 stoichiometric equation (44)计量系数 stoichiometric coefficient (45)价数规则 rule of valence (45)简并度 degeneracy (45)键焓bond enthalpy (45)胶冻 broth jelly (45)胶核 colloidal nucleus (45)胶凝作用 demulsification (45)胶束micelle (45)胶体 colloid (45)胶体分散系统 dispersion system of colloid (45)胶体化学 collochemistry (45)胶体粒子 colloidal particles (45)胶团 micelle (45)焦耳Joule (45)焦耳-汤姆生实验 Joule-Thomson experiment (46)焦耳-汤姆生系数 Joule-Thomson coefficient (46)焦耳-汤姆生效应 Joule-Thomson effect (46)焦耳定律 Joule's law (46)接触电势contact potential (46)接触角 contact angle (46)节流过程 throttling process (46)节流膨胀 throttling expansion (46)节流膨胀系数 coefficient of throttling expansion (46)结线 tie line (46)结晶热heat of crystallization (47)解离化学吸附 dissociation chemical adsorption (47)界面 interfaces (47)界面张力 surface tension (47)浸湿 immersion wetting (47)浸湿功 immersion wetting work (47)精馏 rectify (47)聚(合)电解质polyelectrolyte (47)聚沉 coagulation (47)聚沉值 coagulation value (47)绝对反应速率理论 absolute reaction rate theory (47)绝对熵 absolute entropy (47)绝对温标absolute temperature scale (48)绝热过程 adiabatic process (48)绝热量热计adiabatic calorimeter (48)绝热指数 adiabatic index (48)卡诺定理 Carnot theorem (48)卡诺循环 Carnot cycle (48)开尔文公式 Kelvin formula (48)柯诺瓦洛夫-吉布斯定律 Konovalov-Gibbs law (48)科尔劳施离子独立运动定律 Kohlrausch’s Law of Independent Migration of Ions (48)可能的电解质potential electrolyte (49)可逆电池 reversible cell (49)可逆过程 reversible process (49)可逆过程方程 reversible process equation (49)可逆体积功 reversible volume work (49)可逆相变 reversible phase change (49)克拉佩龙方程 Clapeyron equation (49)克劳修斯不等式 Clausius inequality (49)克劳修斯-克拉佩龙方程 Clausius-Clapeyron equation (49)控制步骤 control step (50)库仑计 coulometer (50)扩散控制 diffusion controlled (50)拉普拉斯方程 Laplace’s equation (50)拉乌尔定律 Raoult law (50)兰格缪尔-欣谢尔伍德机理 Langmuir-Hinshelwood mechanism (50)雷利公式 Rayleigh equation (50)兰格缪尔吸附等温式 Langmuir adsorption isotherm formula (50)冷冻系数coefficient of refrigeration (50)冷却曲线 cooling curve (51)离解热heat of dissociation (51)离解压力dissociation pressure (51)离域子系统 non-localized particle systems (51)离子的标准摩尔生成焓 standard molar formation of ion (51)离子的电迁移率 mobility of ions (51)离子的迁移数 transport number of ions (51)离子独立运动定律 law of the independent migration of ions (51)离子氛 ionic atmosphere (51)离子强度 ionic strength (51)理想混合物 perfect mixture (52)理想气体 ideal gas (52)理想气体的绝热指数 adiabatic index of ideal gases (52)理想气体的微观模型 micro-model of ideal gas (52)理想气体反应的等温方程 isothermal equation of ideal gaseous reactions (52)理想气体绝热可逆过程方程 adiabatic reversible process equation of ideal gases (52)理想气体状态方程 state equation of ideal gas (52)理想稀溶液 ideal dilute solution (52)理想液态混合物 perfect liquid mixture (52)粒子 particles (52)粒子的配分函数 partition function of particles (53)连串反应consecutive reactions (53)链的传递物 chain carrier (53)链反应 chain reactions (53)量热熵 calorimetric entropy (53)量子统计quantum statistics (53)量子效率 quantum yield (53)临界参数 critical parameter (53)临界常数 critical constant (53)临界点 critical point (53)临界胶束浓度critical micelle concentration (53)临界摩尔体积 critical molar volume (54)临界温度 critical temperature (54)临界压力 critical pressure (54)临界状态 critical state (54)零级反应zero order reaction (54)流动电势 streaming potential (54)流动功 flow work (54)笼罩效应 cage effect (54)路易斯-兰德尔逸度规则 Lewis-Randall rule of fugacity (54)露点 dew point (54)露点线 dew point line (54)麦克斯韦关系式 Maxwell relations (55)麦克斯韦速率分布 Maxwell distribution of speeds (55)麦克斯韦能量分布 MaxwelIdistribution of energy (55)毛细管凝结 condensation in capillary (55)毛细现象 capillary phenomena (55)米凯利斯常数 Michaelis constant (55)摩尔电导率 molar conductivity (56)摩尔反应焓 molar reaction enthalpy (56)摩尔混合熵 mole entropy of mixing (56)摩尔气体常数 molar gas constant (56)摩尔热容 molar heat capacity (56)摩尔溶解焓 mole dissolution enthalpy (56)摩尔稀释焓 mole dilution enthalpy (56)内扩散控制 internal diffusions control (56)内能 internal energy (56)内压力 internal pressure (56)能级 energy levels (56)能级分布 energy level distribution (57)能量均分原理 principle of the equipartition of energy (57)能斯特方程 Nernst equation (57)能斯特热定理 Nernst heat theorem (57)凝固点 freezing point (57)凝固点降低 lowering of freezing point (57)凝固点曲线 freezing point curve (58)凝胶 gelatin (58)凝聚态 condensed state (58)凝聚相 condensed phase (58)浓差超电势 concentration over-potential (58)浓差极化 concentration polarization (58)浓差电池 concentration cells (58)帕斯卡pascal (58)泡点 bubble point (58)泡点线 bubble point line (58)配分函数 partition function (58)配分函数的析因子性质 property that partition function to be expressed as a product of the separate partition functions for each kind of state (58)碰撞截面 collision cross section (59)碰撞数 the number of collisions (59)偏摩尔量 partial mole quantities (59)平衡常数(理想气体反应) equilibrium constants for reactions of ideal gases (59)平动配分函数 partition function of translation (59)平衡分布 equilibrium distribution (59)平衡态 equilibrium state (60)平衡态近似法 equilibrium state approximation (60)平衡状态图 equilibrium state diagram (60)平均活度 mean activity (60)平均活度系统 mean activity coefficient (60)平均摩尔热容 mean molar heat capacity (60)平均质量摩尔浓度 mean mass molarity (60)平均自由程mean free path (60)平行反应parallel reactions (61)破乳 demulsification (61)铺展 spreading (61)普遍化范德华方程 universal van der Waals equation (61)其它功 the other work (61)气化热heat of vaporization (61)气溶胶 aerosol (61)气体常数 gas constant (61)气体分子运动论 kinetic theory of gases (61)气体分子运动论的基本方程 foundamental equation of kinetic theory of gases (62)气溶胶 aerosol (62)气相线 vapor line (62)迁移数 transport number (62)潜热latent heat (62)强度量 intensive quantity (62)强度性质 intensive property (62)亲液溶胶 hydrophilic sol (62)氢电极 hydrogen electrodes (62)区域熔化zone melting (62)热 heat (62)热爆炸 heat explosion (62)热泵 heat pump (63)热功当量mechanical equivalent of heat (63)热函heat content (63)热化学thermochemistry (63)热化学方程thermochemical equation (63)热机 heat engine (63)热机效率 efficiency of heat engine (63)热力学 thermodynamics (63)热力学第二定律 the second law of thermodynamics (63)热力学第三定律 the third law of thermodynamics (63)热力学第一定律 the first law of thermodynamics (63)热力学基本方程 fundamental equation of thermodynamics (64)热力学几率 thermodynamic probability (64)热力学能 thermodynamic energy (64)热力学特性函数characteristic thermodynamic function (64)热力学温标thermodynamic scale of temperature (64)热力学温度thermodynamic temperature (64)热熵thermal entropy (64)热效应heat effect (64)熔点曲线 melting point curve (64)熔化热heat of fusion (64)溶胶 colloidal sol (65)溶解焓 dissolution enthalpy (65)溶液 solution (65)溶胀 swelling (65)乳化剂 emulsifier (65)乳状液 emulsion (65)润湿 wetting (65)润湿角 wetting angle (65)萨克尔-泰特洛德方程 Sackur-Tetrode equation (66)三相点 triple point (66)三相平衡线 triple-phase line (66)熵 entropy (66)熵判据 entropy criterion (66)熵增原理 principle of entropy increase (66)渗透压 osmotic pressure (66)渗析法 dialytic process (67)生成反应 formation reaction (67)升华热heat of sublimation (67)实际气体 real gas (67)舒尔采-哈迪规则 Schulze-Hardy rule (67)松驰力relaxation force (67)松驰时间time of relaxation (67)速度常数reaction rate constant (67)速率方程rate equations (67)速率控制步骤rate determining step (68)塔费尔公式 Tafel equation (68)态-态反应 state-state reactions (68)唐南平衡 Donnan equilibrium (68)淌度 mobility (68)特鲁顿规则 Trouton rule (68)特性粘度 intrinsic viscosity (68)体积功 volume work (68)统计权重 statistical weight (68)统计热力学 statistic thermodynamics (68)统计熵 statistic entropy (68)途径 path (68)途径函数 path function (69)外扩散控制 external diffusion control (69)完美晶体 perfect crystalline (69)完全气体 perfect gas (69)微观状态 microstate (69)微态 microstate (69)韦斯顿标准电池 Weston standard battery (69)维恩效应Wien effect (69)维里方程 virial equation (69)维里系数 virial coefficient (69)稳流过程 steady flow process (69)稳态近似法 stationary state approximation (69)无热溶液athermal solution (70)无限稀溶液 solutions in the limit of extreme dilution (70)物理化学 Physical Chemistry (70)物理吸附 physisorptions (70)吸附 adsorption (70)吸附等量线 adsorption isostere (70)吸附等温线 adsorption isotherm (70)吸附等压线 adsorption isobar (70)吸附剂 adsorbent (70)吸附量 extent of adsorption (70)吸附热 heat of adsorption (70)吸附质 adsorbate (70)析出电势 evolution or deposition potential (71)稀溶液的依数性 colligative properties of dilute solutions (71)稀释焓 dilution enthalpy (71)系统 system (71)系统点 system point (71)系统的环境 environment of system (71)相 phase (71)相变 phase change (71)相变焓 enthalpy of phase change (71)相变化 phase change (71)相变热 heat of phase change (71)相点 phase point (71)相对挥发度relative volatility (72)相对粘度 relative viscosity (72)相律 phase rule (72)相平衡热容heat capacity in phase equilibrium (72)相图 phase diagram (72)相倚子系统 system of dependent particles (72)悬浮液 suspension (72)循环过程 cyclic process (72)压力商 pressure quotient (72)压缩因子 compressibility factor (73)压缩因子图 diagram of compressibility factor (73)亚稳状态 metastable state (73)盐桥 salt bridge (73)盐析 salting out (73)阳极 anode (73)杨氏方程 Young’s equation (73)液体接界电势 liquid junction potential (73)液相线 liquid phase lines (73)一级反应first order reaction (73)一级相变first order phase change (74)依时计量学反应 time dependent stoichiometric reactions (74)逸度 fugacity (74)逸度系数 coefficient of fugacity (74)阴极 cathode (75)荧光 fluorescence (75)永动机 perpetual motion machine (75)永久气体 Permanent gas (75)有效能 available energy (75)原电池 primary cell (75)原盐效应 salt effect (75)增比粘度 specific viscosity (75)憎液溶胶 lyophobic sol (75)沾湿 adhesional wetting (75)沾湿功 the work of adhesional wetting (75)真溶液 true solution (76)真实电解质real electrolyte (76)真实气体 real gas (76)真实迁移数true transference number (76)振动配分函数 partition function of vibration (76)振动特征温度 characteristic temperature of vibration (76)蒸气压下降 depression of vapor pressure (76)正常沸点 normal point (76)正吸附 positive adsorption (76)支链反应 branched chain reactions (76)直链反应 straight chain reactions (77)指前因子 pre-exponential factor (77)质量作用定律mass action law (77)制冷系数coefficient of refrigeration (77)中和热heat of neutralization (77)轴功 shaft work (77)转动配分函数 partition function of rotation (77)转动特征温度 characteristic temperature of vibration (78)转化率 convert ratio (78)转化温度conversion temperature (78)状态 state (78)状态方程 state equation (78)状态分布 state distribution (78)状态函数 state function (78)准静态过程quasi-static process (78)准一级反应 pseudo first order reaction (78)自动催化作用 auto-catalysis (78)自由度 degree of freedom (78)自由度数 number of degree of freedom (79)自由焓free enthalpy (79)自由能free energy (79)自由膨胀free expansion (79)组分数 component number (79)最低恒沸点 lower azeotropic point (79)最高恒沸点 upper azeotropic point (79)最佳反应温度 optimal reaction temperature (79)最可几分布 most probable distribution (80)最可几速率 most propable speed (80)概念及术语BET公式BET formula1938年布鲁瑙尔(Brunauer)、埃米特(Emmett)和特勒(Teller)三人在兰格缪尔单分子层吸附理论的基础上提出多分子层吸附理论。
颅底中英文孔口诀

The Chinese and English mnemonics for skill base foreamina are different in their language and cultural background, but they share the same purpose of helping people remember the names and locations of the foreamina
Classification and
characteristics of Chinese
and English origin
02
formulas for the skill base
A mnemonic for the forest of the enemy criminal fossa
Summary
Definition and characteristics
Definition
The skull base foramina is the foramina on the base of the skull, which are the openings for nerves and blood vessels to pass through Mnemonics are a set of memory aids used to help people remember information
Future prospects
With the continuous advancement of medical science, it is expected that the Chinese and English mnemonics for skill base will continue to evolve, further improving medical education and clinical practice
Oscillating cosmological solutions within gauge theories of gravity

Abstract New type of nonsingular oscillating solutions for the Universe described by cosmological equations of gauge theories of gravity is presented. Advantages of these solutions with respect to existing nonsingular solutions within framework of general relativity and gauge gravity are discussed. It is shown in particular that these solutions have nonzero measure and stable on contraction stage unlike usual nonsingular solutions. Key words: initial singularity, bouncing models, gauge theories of gravity PACS: 98.80Cq
(2)
where R(t) is the scale factor in the Robertson-Walker metric, k = −1, 0, +1 for open, flat and closed models respectively, Mp is planckian mass, ρ(t) and p(t) are energy density and pressure, β is indefinite parameter, and a dot denotes the differentiation with respect to time 1 . These equations contain the only indefinite parameter β that is a combination of gravitational lagrangian coefficients, having a dimension of inverse energy density. Solutions of cosmological equations have essentially non-einsteinian behavior when the energy density exceeds the critical value β −1. Experimental 4 constraints on parameter β are very poor and one can say only that β −1 ≤ Mp . Besides equations (1-2) gravitational equations of GTG lead to the following relation for torsion function S and nonmetricity function Q 1 1d S− Q=− ln[1 − β (ρ − 3p)]. 4 4 dt (3)ations
One-Loop Riemann Surfaces in Schnabl Gauge

1
1
Introduction
The string field Φ that represents the tachyon vacuum in Schnabl’s solution [1] of open string field theory [2] satisfies a novel gauge condition. The solution is not in Siegel gauge [3]: Φ is not annihilated by the zero mode b0 of the antighost field in the canonical open string frame. Rather, Φ is annihilated by the zero mode B of the antighost field in the conformal frame of the sliver projector of the star algebra of open string fields. The sliver frame is central to the construction and analysis of classical solutions [4]–[30] but, as any projector frame, it is singular at the open string midpoint. One can wonder if the Schnabl gauge condition B Φ = 0 defines a consistent open string perturbation theory. In this question, the singular behavior of the open string midpoint has brought interesting advantages but has also introduced some new subtleties. At tree level, the sliver frame makes all conformal maps from the string diagrams to the upper-half plane very simple [31, 32]. This is remarkable, if we recall that in Siegel gauge these maps are extremely complicated and no closed form expressions are known except for four-string amplitudes [33]. The subtleties arise because there are delicate contributions whose origin can be traced to the singular behavior at the open string midpoint [32]. These contributions affect the off-shell part of four-string amplitudes and could affect higher-point functions on-shell. No Feynman rules are known that deal with these complications in general tree-level amplitudes. This state of affairs prompted [34] to introduce a class of regular linear b-gauges that produce correct on-shell amplitudes. In this class, a propagator insertion with Schwinger parameter approaching infinity induces an open string degeneration of the Riemann surface associated with the string diagram– the desired behavior. Schnabl gauge does not belong to the class of regular b-gauges, but there is a simple one-parameter family of regular linear b-gauges that interpolates between Siegel and Schnabl gauge as its parameter λ goes from infinity to zero. This suggests that Schnabl gauge amplitudes can be obtained by taking the limit λ → 0 of the well-behaved amplitudes in this λ-family. While it is not yet proven that moduli space is covered for general tree amplitudes in Schnabl gauge, it is no mystery how the relevant Riemann surfaces –disks with boundary punctures – carry the moduli and how degenerations can be generated. Naive arguments, however, suggest that Schnabl gauge at loop level only produces surfaces with degenerate closed string moduli, thus making it impossible to reproduce the correct on-shell amplitudes. In a one-loop amplitude, for example, the line traced by the open string midpoint is a nontrivial closed curve. In the Schnabl propagator the open string midpoint does not move, thus naively suggesting a diagram with a zero-length closed curve that signals closed string degeneration. It is the main purpose of this paper to discuss the one-loop string diagrams in Schnabl gauge. Our results are quite encouraging. We find that the anticipated problems with closed string moduli are not present. Our main tool is the regulation provided by the λ-family of regular linear 2
高良姜素减轻异丙肾上腺素诱导心脏纤维化的作用机制

高良姜素减轻异丙肾上腺素诱导心脏纤维化的作用机制尚茹茹1,童曼琳2,刘晓红1摘要目的:探讨高良姜素(Galangin)对异丙肾上腺素(ISO)诱导心脏纤维化的作用机制㊂方法:将30只C57BL/6小鼠随机分为正常组㊁ISO组㊁高良姜素低剂量组[25mg/(kg㊃d)]㊁高良姜素中剂量组[50mg/(kg㊃d)]㊁高良姜素高剂量组[100mg/(kg㊃d)]㊂处理结束后行心脏超声评估心功能[左室射血分数(LVEF)㊁左室短轴缩短率(LVFS)㊁左室收缩末期内径(LVESD)㊁左室舒张末期内径(LVEDD)];测量小鼠体质量(BW)㊁心脏重量(HW)㊁胫骨长度(TL),计算心脏重量与体质量比值(HW/BW)㊁心脏重量与胫骨长度比值(HW/TL),评估心肌肥厚情况㊂天狼星红染色评价心脏纤维化程度;实时荧光定量聚合酶链式反应(qPCR)检测炎症标志物白细胞介素-6(IL-6)㊁白细胞介素-1β(IL-1β)㊁肿瘤坏死因子-α(TNF-α)和纤维化标志物胶原蛋白Ⅰ(CollagenⅠ)㊁胶原蛋白Ⅲ(CollagenⅢ)㊁转化生长因子-β1(TGF-β1)mRNA水平;试剂盒检测心脏组织氧化应激指标超氧化物歧化酶(SOD)㊁过氧化氢酶(CAT)活性和丙二醛(MDA)含量㊂结果:与正常组比较,ISO组小鼠HW/BW㊁HW/TL㊁LVEDD及LVESD升高,LVEF和LVFS降低,IL-6㊁IL-1β㊁TNF-α㊁CollagenⅠ㊁CollagenⅢ和TGF-β1mRNA表达水平升高,心脏SOD和CAT活性降低,MDA含量升高,心肌细胞横截面积增大,心脏纤维化面积增加(P<0.05)㊂与ISO组比较,高良姜素高剂量组心脏纤维化面积减小,CollagenⅠ㊁CollagenⅢ㊁IL-6mRNA表达水平降低,SOD活性升高,MDA含量降低,差异有统计学意义(P<0.05)㊂高良姜素中剂量组TGF-β1低于ISO组,差异有统计学意义(P<0.05)㊂结论:高良姜素可减轻ISO诱导的心脏纤维化,其机制可能与抑制炎症㊁氧化应激有关㊂关键词心脏纤维化;高良姜素;异丙肾上腺素;炎症;氧化应激;小鼠;实验研究d o i:10.12102/j.i s s n.1672-1349.2023.24.009Mechanism of Galangin on Isoprenaline-induced Cardiac FibrosisSHANG Ruru,TONG Manlin,LIU XiaohongShanxi Provincial People's Hospital,Taiyuan030012,Shanxi,ChinaCorresponding Author LIU Xiaohong,E-mail:****************Abstract Objective:To investigate the mechanism of Galangin on isoprenaline(ISO)-induced cardiac fibrosis.Methods:Thirty C57BL/6 mice were randomly divided into the normal group,ISO group,low-dose galangin group[25mg/(kg㊃d)],medium-dose galangin group [50mg/(kg㊃d)],and high-dose galangin group[100mg/(kg㊃d)].After treatment,cardiac ultrasound was performed to detect cardiac function[left ventricular ejection fraction(LVEF),left ventricular short-axis shortening(LVFS),left ventricular end-systolic internal diameter(LVESD),and left ventricular end-diastolic internal diameter(LVEDD)].The body mass(BW),heart weight(HW),and tibia length (TL)of the mice were measured,and the heart weight-weight to body mass ratio(HW/BW)was detected,and the heart weight to tibia length ratio(HW/TL)were collected to assess cardiac hypertrophy.The degree of cardiac fibrosis was detected by sirius scarlet staining.The inflammatory markers interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and fibrotic markers collagen Ⅰ(CollagenⅠ),collagenⅢ(CollagenⅢ),transforming growth factor-β1(TGF-β1)mRNA levels were detected by real-time fluorescence quantitative polymerase chain reaction(qPCR).The kit was used to detect the oxidative stress indicators superoxide dismutase(SOD), catalase(CAT)activity,and malondialdehyde(MDA)content in heart tissue.Results:Compared with the normal group,HW/BW,HW/TL, LVEDD,and LVESD in the ISO group were higher,LVEF and LVFS were less,levels of IL-6,IL-1β,TNF-α,CollagenⅠ,CollagenⅢ,and TGF-β1mRNA were higher,SOD and CAT activities were less,and MDA content was higher.The cardiomyocyte cross-sectional area and cardiac fibrosis area were higher(P<0.05).Compared with the ISO group,the area of cardiac fibrosis was less in the high-dose galangin group,the expression levels of CollagenⅠ,CollagenⅢ,and the mRNA of IL-6were less,the activity of SOD was higher,and the content of MDA was less(P<0.05).TGF-β1in the medium-dose galangin group was less than that in the ISO group(P<0.05). Conclusion:Galangin could alleviate isoproterenol-induced cardiac fibrosis,and its mechanism might be related to inhibiting inflammation and oxidative stress.Keywords cardiac fibrosis;Galangin;isoproterenol;inflammation;oxidative stress;mice;experimental study心力衰竭是心血管疾病的终末阶段,发病率及死基金项目山西省卫生健康委科研课题项目(No.2021112)作者单位 1.山西省人民医院(太原030012);2.山西医科大学第五临床医学院通讯作者刘晓红,E-mail:****************引用信息尚茹茹,童曼琳,刘晓红.高良姜素减轻异丙肾上腺素诱导心脏纤维化的作用机制[J].中西医结合心脑血管病杂志,2023,21(24): 4524-4529.亡率均较高,心力衰竭发生机制复杂,尚未明确㊂目前认为神经内分泌系统激活导致的心室重塑是引起心力衰竭的关键因素,心脏纤维化是心室重塑的主要病理特征,炎症在心脏纤维化过程中发挥着重要作用[1]㊂心力衰竭发展过程中产生大量的促炎因子,这些促炎因子导致心肌细胞肥大和心脏纤维化㊂因此,抑制心脏炎症㊁纤维化有助于改善心力衰竭预后㊂高良姜素(Galangin,3,5,7-三羟基黄酮)是一种天然来源的黄酮醇类化合物,主要分布于姜科植物高良姜的干燥根茎中㊂多项研究显示,高良姜素具有抗炎㊁抗氧化㊁抗凋亡㊁抗肿瘤及抗纤维化等作用[2-3]㊂有研究显示,高良姜素可减少活性氧生成,抑制丝裂原活化蛋白激酶(MAPK)信号通路,减轻哮喘小鼠气道炎症反应及气道重塑[4]㊂本研究探讨高良姜素通过抗炎㊁抗氧化㊁抗纤维化等抑制心脏纤维化发挥抗心力衰竭的作用机制㊂1材料与方法1.1实验材料1.1.1动物模型及分组C57BL/6小鼠购自北京斯贝福生物技术有限公司[生产许可证:SCK(京)2019-0010],6~8周龄,雄性,体质量23.5~25.5g㊂饲养于无特定病原体(SFP)级环境中,自由摄取食物,昼夜12h㊂异丙肾上腺素(ISO)组(6只)小鼠在实验第1日皮下注射ISO[5mg/(kg㊃d)],共治疗14d,之后每日灌胃对应体积的0.5%羟甲基纤维素溶液,持续4周㊂高良姜素各剂量组(每组6只)在实验第1天皮下注射ISO[5mg/(kg㊃d)]同时给予不同浓度的高良姜素(重悬于0.5%羟甲基纤维素溶液,每次灌胃前混匀)灌胃,ISO使用14d,之后持续灌胃高良姜素至4周㊂正常组(6只)从实验开始每日灌胃对应体积的0.5%羟甲基纤维素溶液,持续4周㊂详见图1㊂图1小鼠的处理方法(CMC为羧甲基纤维素;Gla为高良姜素)1.1.2实验试剂与仪器高良姜素(上海融禾医药科技发展有限公司); ISO(sigma,美国);异硫氰酸荧光素(FITC)标记的麦胚芽凝集素(WGA)染色试剂盒(Sigma,美国);天狼星红染色试剂盒(北京索莱宝);超氧化物歧化酶(SOD)试剂盒(南京建成);丙二醛(MDA)试剂盒(南京建成);过氧化氢酶(CAT)试剂盒(南京建成);心脏超声测量系统(美国GE公司Vivid7pro超声系统);荧光显微镜(Nikon);实时荧光定量聚合酶链式反应(qPCR)仪(Bio-Rad)㊂1.2方法1.2.1小鼠心脏超声心动图检查实验4周,行心脏彩超检测小鼠左室射血分数(LVEF)㊁左室短轴缩短率(LVFS)㊁左室收缩末期内径(LVESD)㊁左室舒张末期内径(LVEDD),上述数据测量3次,取平均值,记录分析㊂1.2.2小鼠体质量㊁心脏重量及胫骨长度检测完成心脏超声的小鼠,测量体质量(body weight, BW),每只小鼠称量3次,取平均值并记录㊂给予1%戊巴比妥钠溶液(20mg/kg)腹腔注射,前胸部开口,暴露心脏,心尖部穿刺,用肝素盐水灌注5min,取材㊂测量心脏重量(heart weight,HW)㊁胫骨长度(tibial length,TL)㊂计算心脏重量与体质量比值(HW/BW)㊁心脏重量与胫骨长度比值(HW/TL)㊂1.2.3组织取材㊁石蜡切片制备㊁常规染色组织取材后,经10%甲醛固定,乙醇脱水㊁石蜡包埋,垂直于心脏长轴连续切成5μm的石蜡组织切片,进行WGA染色㊂采用Nikon显微镜收集图像,并使用Image J软件进行定量分析㊂1.2.4qPCR检测提取小鼠心脏组织总RNA后,将2μg的RNA按照说明书反转录为cDNA㊂应用SYBR(Servicebio公司),按照说明书检测相关基因,引物序列如下:胶原蛋白(Collagen)Ⅰ,正向引物5'AAGAAGCACGTCTG-GTTTGGAG3',反向引物5'GGTCCATGTAGGC-TACGCTGTT3';CollagenⅢ,正向引物5'TTTCTTCT-CACCCTTCTTCATCC3',反向引物5'CATATTTGA-CATGGTTCTGGCTTC3';转化生长因子-β1(TGF-β1),正向引物5'TAATGGTGGACCGCAACAAC3',反向引物5'CCACATGTTGCTCCACACTTGAT3';白细胞介素-1β(IL-1β),正向引物5'TCAAATCTCGCAGCAG-CACATC3',反向引物5'CGTCACACACCAGCAGGT-TATC3';IL-6,正向引物5'CCCCAATTTCCAAT-GCTCTCC3';反向引物5'CGCACTAGGTTTGC-CGAGTA3';肿瘤坏死因子-α(TNF-α),正向引物5' CCCTCACACTCACAAACCACC3',反向引物5'CTTT-GAGA TCCA TGCCGTTG3';磷酸甘油醛脱氢酶(GAPDH),正向引物5'CCTCGTCCCGTAGACAAAATG3',反向引物5'TGAGGTCAATGAAGGGGTCGT3'㊂1.2.5心脏组织氧化应激水平检测取适量心脏组织,按照试剂盒说明书步骤分别进行SOD和CA T活性检测,同时检测心脏组织MDA含量㊂1.3统计学处理采用SPSS26.0统计软件对数据进行分析,符合正态分布的定量资料以均数ʃ标准差(xʃs)表示,组间比较采用独立样本t检验,多组间比较采用单因素方差分析㊂以P<0.05为差异有统计学意义㊂统计图表制作使用GraphPad Prism9.5软件完成㊂2结果2.1各组小鼠心脏组织形态学比较与正常组比较,ISO组小鼠HW/BW㊁HW/TL升高,差异有统计学意义(P<0.05)㊂详见图2㊂图2各组小鼠心脏组织形态学比较(A为HW/BW;B为HW/TL㊂与正常组比较,*P<0.05)2.2各组小鼠心肌细胞横截面积及心脏纤维化面积比较WGA染色结果显示:与正常组比较,ISO组小鼠心肌细胞横截面积增大(P<0.05)㊂天狼星红染色结果显示,与正常组比较,ISO组小鼠心脏纤维化程度加重(P<0.05);与ISO组比较,高良姜素高剂量组心脏纤维化程度减轻(P<0.05)㊂详见图3㊁图4㊂图3各组小鼠心肌细胞横截面积及心脏纤维化染色图(ˑ400) (A为WGA染色代表图;B为天狼星红染色代表图)图4各组小鼠心肌细胞横截面积及心脏纤维化面积比较柱状图(A为心肌细胞横截面积;B为心脏纤维化面积㊂与正常组比较,*P<0.05;与ISO组比较,#P<0.05)2.3各组小鼠心功能指标比较与正常组比较,ISO组小鼠LVEF和LVFS下降,LVEDD㊁LVESD升高,差异有统计学意义(P<0.05)㊂详见图5㊂图5各组小鼠心功能指标比较的柱状图(A为LVEF;B为LVFS;C为LVEDD;D为LVESD㊂与正常组比较,*P<0.05)2.4各组小鼠心脏CollagenⅠ㊁CollagenⅢ㊁TGF-β1 mRNA表达水平比较与正常组比较,ISO组小鼠心脏纤维化标志物CollagenⅠ㊁CollagenⅢ㊁TGF-β1mRNA表达水平升高(P<0.05)㊂与ISO组比较,高良姜素高剂量组心脏纤维化标志物CollagenⅠ㊁CollagenⅢmRNA水平降低,高良姜素中剂量组心脏纤维化标志物TGF-β1 mRNA表达水平降低,差异有统计学意义(P<0.05)㊂详见图6㊂图6各组小鼠心脏CollagenⅠ㊁CollagenⅢ㊁TGF-β1mRNA表达水平比较的柱状图(A为CollagenⅠmRNA;B为CollagenⅢmRNA表达水平;C为TGF-β1mRNA表达水平㊂与正常组比较,*P<0.05;与ISO组比较,#P<0.05)2.5各组小鼠心脏组织IL-6㊁IL-1β㊁TNF-αmRNA表达水平比较与正常组比较,ISO组心脏炎症标志物IL-6㊁IL-1β㊁TNF-αmRNA表达水平升高(P<0.05)㊂与ISO组比较,高良姜素高剂量组心脏炎症标志物IL-6mRNA降低,差异有统计学意义(P<0.05)㊂详见图7㊂图7各组小鼠心脏组织IL-6㊁IL-1β㊁TNF-αmRNA表达水平比较的柱状图(A为IL-6mRNA表达水平;B为IL-1βmRNA表达水平;C为TNF-αmRNA表达水平㊂与正常组比较,*P<0.05;与ISO组比较,#P<0.05)2.6各组小鼠心脏组织氧化应激指标SOD㊁MDA㊁CAT水平比较与正常组比较,ISO组小鼠心脏组织SOD㊁CAT 活性降低,心脏组织MDA含量升高,差异有统计学意义(P<0.05)㊂与ISO组比较,高良姜素高剂量组SOD活性升高,MDA含量下降,差异有统计学意义(P< 0.05)㊂详见图8㊂图8各组小鼠心脏组织氧化应激指标SOD㊁MDA㊁CAT水平比较的柱状图(A为心脏组织SOD活性;B为心脏组织CAT的活性;C为心脏组织MDA含量㊂与正常组比较,*P<0.05;与ISO组比较,#P<0.05)3讨论心室重塑是心力衰竭发生发展中的重要病理过程,心肌细胞在持续压力超负荷㊁缺血㊁缺氧㊁炎症等应激条件下发生结构和功能改变,包括左心室形态改变㊁心肌细胞肥大和间质纤维化㊁心肌细胞凋亡[5]㊂心肌损伤的早期阶段,大量的炎症细胞浸润到心肌损伤区域并发挥作用㊂促炎信号通路是由多种促炎细胞因子(如TNF-α㊁IL-17㊁IL-1β㊁IL-6)介导的,可诱导心肌细胞肥大和凋亡,进一步加重炎症和纤维化,最终导致心室重塑[6]㊂氧化应激损伤在心脏纤维化过程中发挥着关键作用㊂病理情况下,活性氧过量积累导致脂质过氧化反应发生,促使细胞损伤和死亡,引起细胞功能障碍[7]㊂活性氧分子经抗氧化酶如CAT和SOD降解为无毒分子㊂抗氧化防御机制(SOD㊁CAT)或内源性抗氧化剂(维生素E㊁抗坏血酸和谷胱甘肽)浓度降低可增加活性氧水平㊂有研究显示,心力衰竭病人血浆和心包积液中脂质过氧化物水平升高,与病人严重程度呈正相关[7]㊂活性氧引发心脏成纤维细胞增殖,激活核因子-κB (nuclear factor kappa B,NF-κB),以此增加基质金属蛋白酶表达,导致细胞外基质聚集,促进心肌纤维化[8]㊂相关研究表明,竹叶提取物通过缓解氧化应激损伤,减轻糖尿病诱导的心脏纤维化[9]㊂有研究显示,顺铂诱导的小鼠肾损伤过程中,高良姜素通过抗炎㊁抗氧化应激及抗凋亡作用发挥肾脏保护作用[10];在链脲霉素诱导的糖尿病大鼠中,高良姜素通过改善肝脏的抗氧化应激水平,维持高血糖大鼠肝脏的线粒体功能[11];高良姜素通过抑制炎性因子表达,减轻尿酸诱导的肾脏炎症反应[12]㊂本研究结果显示,在ISO诱导的心脏损伤及纤维化模型中,高良姜素干预后降低了HW/BW㊁HW/TL,减轻了心肌间质纤维化程度,缩小了心肌细胞的横截面积,改善了心功能;高良姜素干预后下调了心脏炎症标志物(IL-6㊁IL-1β㊁TNF-α)和心脏纤维化标志物(CollagenⅠ㊁CollagenⅢ㊁TGF-β1)mRNA表达水平,同时升高了心脏组织中抗氧化酶SOD㊁CAT活性,降低了心脏组织中脂质氧化物MDA的含量㊂综上所述,高良姜素通过减轻心脏炎症反应㊁心脏氧化应激反应,抑制心脏成纤维细胞向肌成纤维细胞转化,从而减轻ISO诱导的心脏损伤及纤维化㊂但具体分子机制尚未明确,在今后的研究中将深入探讨㊂参考文献:[1]SHIRAZI L F,BISSETT J,ROMEO F,et al.Role of inflammation inheart failure[J].Current Atherosclerosis Reports,2017,19(6):27. [2]ABUKHALIL M H,ALTHUNIBAT O Y,ALADAILEH S H,et al.Galangin attenuates diabetic cardiomyopathy through modulatingoxidative stress,inflammation and apoptosis in rats[J].Biomedecine&Pharmacotherapie,2021,138:111410. [3]TANG X X,XU C M,YAGIZ Y,et al.Phytochemical profiles,andantimicrobial and antioxidant activities of greater galangal[Alpinia galanga(Linn.)Swartz]flowers[J].Food Chemistry,2018,255:300-308.[4]LIU Y N,ZHA W J,MA Y,et al.Galangin attenuates airwayremodelling by inhibiting TGF-β1-mediated ROS generation andMAPK/AKT phosphorylation in asthma[J].Scientific Reports,2015,5:11758.[5]GAO G Y,CHEN W W,YAN M J,et al.Rapamycin regulates thebalance between cardiomyocyte apoptosis and autophagy inchronic heart failure by inhibiting mTOR signaling[J].International Journal of Molecular Medicine,2020,45(1):195-209.[6]ADAMO L,ROCHA-RESENDE C,PRABHU S D,et al.Reappraising the role of inflammation in heart failure[J].NatureReviews Cardiology,2020,17(5):269-285.[7]TSUTSUI H,KINUGAWA S,MATSUSHIMA S.Oxidative stressand heart failure[J].American Journal of Physiology Heart andCirculatory Physiology,2011,301(6):H2181-H2190.[8]MARCHIOLI R,LEVANTESI G,MACCHIA A,et al.Vitamin Eincreases the risk of developing heart failure after myocardialinfarction:results from the GISSI-Prevenzione trial[J].Journal ofCardiovascular Medicine,2006,7(5):347-350.[9]ZHANG L L,MAO Y Z,PAN J J,et al.Bamboo leaf extractameliorates cardiac fibrosis possibly via alleviating inflammation,oxidative stress and apoptosis[J].Biomedicine&Pharmacotherapy,2017,95:808-817.[10]TOMAR A,VASISTH S,KHAN S I,et al.Galangin amelioratescisplatin induced nephrotoxicity in vivo by modulation ofoxidative stress,apoptosis and inflammation through interplay ofMAPK signaling cascade[J].Phytomedicine,2017,34:154-161.[11]ALOUD A A,VEERAMANI C,GOVINDASAMY C,et al.Galangin,anatural flavonoid reduces mitochondrial oxidative damage instreptozotocin-induced diabetic rats[J].Redox Report,2018,23(1):29-34.[12]LU H,YAO H,ZOU R,et al.Galangin suppresses renalinflammation via the inhibition of NF-κB,PI3K/AKT and NLRP3inuric acid treated NRK-52E tubular epithelial cells[J].Bio MedResearch International,2019,2019:1-10.(收稿日期:2023-03-17)(本文编辑薛妮)。
Overlap

¯ and ψ are Dirac fermions and the mass matrix M is infinite. It has a single zero ψ mode but its adjoint has no zero modes. As long as MM† > 0 this setup is stable under small deformations of the mass matrix implying that radiative corrections will not wash the zero mode away. Kaplan’s domain wall suggests the following realization: M = −∂s − f (s), (2)
where s ∈ (−∞, ∞) and f is fixed at −Λ′ for negative s and at Λ for positive s (Λ′ , Λ > 0. There is no mathematical difficulty associated with the discontinuity at s = 0. The infinite path integral over the fermions is easily “done”: on the positive and negative segments of the real line respectively one has propagation with an s-independent “Hamiltonian”. The infinite extent means that at s = 0 the path integrals produce the overlap (inner product) between the two ground states of the many fermion systems corresponding to each side of the origin in s. The infinite extent also means infinite exponents linearly proportional to the respective energies - these factors are subtracted. One is left 2
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a r X i v :h e p -l a t /0209072v 1 5 S e p 20021Four–loop logarithms in 3d gauge +Higgs theory ∗K.Kajantie a ,ine b ,K.Rummukainen a ,c and Y.Schr¨o der da Department of Physics,P.O.Box 64,FIN-00014University of Helsinki,Finland bTheory Division,CERN,CH-1211Geneva 23,SwitzerlandcNORDITA,Blegdamsvej 17,DK-2100Copenhagen Ø,Denmark dCenter for Theoretical Physics,MIT,Cambridge,MA 02139,USAWe discuss the logarithmic contributions to the vacuum energy density of the three-dimensional SU(3)+adjoint Higgs theory in its symmetric phase,and relate them to numerical Monte Carlo simulations.We also comment on the implications of these results for perturbative and non-perturbative determinations of the pressure of finite-temperature QCD.HIP-2002-40/TH,CERN-TH/2002-229,NORDITA-2002-59HE,MIT-CTP 3301,hep-lat/02090721.INTRODUCTIONStrongly interacting quantum field theories,such as QCD,require extensive numerical simu-lations,to obtain a non-perturbative understand-ing from first principles.Some regions in param-eter space might however be amenable to ana-lytic methods,which can then be used to obtain a clearer physical picture as well as an independent check on the Monte Carlo (MC)simulations.Fur-thermore,since in practice there are upper limits on computing power,one might combine numer-ical and analytic methods,to supplement each other and provide for a sufficient tool in cases where either method alone would fail.As a concrete example of this interplay,let us study the free energy density f (which,in the thermodynamic limit,equals the negative pres-sure p )of QCD,at finite temperature T and van-ishing baryon chemical potential,e −f (T )V∗Presentedat Lattice 2002by Y.Schr¨o der.T c ∼200MeV.While the low-temperature phase is governed by bound states,such as mesons,the high-temperature phase should,due to asymp-totic freedom,look more like a gas of free quarks and gluons.A direct lattice measurement of f can be and has been performed,see e.g.[1].The results show the pressure rising sharply around T c ,to level offat a few times T c .At higher temperatures,the di-rect numerical approach gets increasingly harder,since ensuring clean continuum as well as thermo-dynamic limits one is facing a multiscale problem,a ≪1T c ≈1MS≈1fm ≪Na ,where a and N are the lattice spacing and the number oflattice sites,respectively.On the other hand,the temperature being the only scale in the problem,perturbative methods are guaranteed to work well at high T ,due to asymptotic freedom.In fact,at vanishing cou-pling one reaches the ideal-gas limit,p ideal (T )=π2T 44N c N f,(1)where N c and N f denote the number of coloursand flavours,respectively.With decreasing tem-perature,the value of the effective coupling con-stant g (T )however increases,rendering a pertur-bative series [2]meaningless below some point.22.METHODProgress can be made by exploiting the scale hierarchy πT >gT >g 2T at high temperatures,enabling one to use the powerful analytic method of effectice theories,allowing to reduce numeri-cal simulations needed for the QCD pressure to a much lessdemanding three-dimensional (3d)bosonictheory[3].The partition function factor-izes,and hence the free energy decomposes into f QCD =f hard +f soft [4].The effective theory for the soft ,O (gT )modes turns out to be dimension-ally reduced,e −Vf soft= D [A i A 0]e −d 3x L 3d [A i A 0],(2)where L 3d is a 3d SU(3)+adjoint Higgs theory,L 3d =ß12[D i ,A 0]2+14λ3A 40.(3)Its coefficients (g 23,m 23,λ3)are functions of T via perturbative matching [5],e.g.,y ≡ßm 238π2ln 8.086TMS.(4)Let us note that for simplicity,this relation refers to the case of pure 4d SU(3),while the inclusion of fermions,as well as (small)chemical potentials,is also possible.For a more detailed account of the setup,we refer to [3].In the following we wish to highlight the specific role of logarithmic terms in f soft .3.3d LATTICE MEASUREMENTS Related to the fact that L 3d defines a confining theory,it turns out that f soft is perturbatively computable only up to 3-loop level,while all higher loop orders contribute at the next level [6].The parametric form of f soft can however still be written down for large y ,f soft (y )=f soft,pert (y )+g 63y1/2).(5)The coefficient c 1here can now be accessedwith lattice methods.Indeed,∂y f soft is related to a gauge-invariant condensate,∂y f soft (y )=g 43 Tr A 20 .(6)y< A 2> - < A 2 >p e r t .Figure ttice results for Tr(A 0/g 3)2MSas a function of y ,βG .Various continuum extrapolated values are also shown.If we also subtract the known perturbative part,we see thatTr(A 0/g 3)2 − Tr(A 0/g 3)2 pert=1y +O (1ag 23,(8)the result is,schematically,that a lattice mea-surement can be converted to a continuum regu-larisation (such asMS∼limβG →∞Tr A 2L+βG +ln βG +1 .(9)In Figs.1,2we show measurements of the con-densate with various finite βG ,as well as contin-uum extrapolations.The (very preliminary)finalresult,after the subtraction of the 3-loop pertur-bative part,is shown in Fig.3.3g 32a< A 2> - < A 2>p e r t .Figure 2.Examples of continuum extrapolationsfor Tr(A 0/g 3)2 MS,at a few selected y .The fits are polynomial.We find that the data can indeedbe well de-scribed by the functional form in Eq.(7),with what appears to be a definite coefficient c 1.This clearly calls for an analytic evaluation of c 1.Previously [3],we have discussed how the non-perturbative measurement of Tr A 20 allows to estimate f soft (y ),and correspondingly f QCD (T ),down to temperatures of a few times T c .Once c 1is reliably extracted,it will be interesting to see how well these results can be reproduced by keep-ing in the expression only this single logarithm.Concluding,we have discussed a method that in principle allows to determine the free energy of full QCD from the known analytic limit at high T ,down to a few times T c .A small set of pertur-bative constants remains to be determined,but these can already be partly constrained with nu-merical 3d MC data.ACKNOWLEDGEMENTSThis work was partly supported by the TMR network Finite Temperature Phase Transitions iny< A 2> - < A 2>p e r t .Figure 3.The continuum extrapolated values ofTr(A 0/g 3)2 MSas a function of y ,together with various fits.A fit linear in y −1describes the data well in a wide range of y .Particle Physics ,EU contract no.FMRX-CT97-0122,by the RTN network Supersymmetry and the Early Universe ,EU contract no.HPRN-CT-2000-00152,by the Academy of Finland,contract no.77744,and by the DOE,under Cooperative Agreement no.DF-FC02-94ER40818.REFERENCES1.G.Boyd et al ,Nucl.Phys.B 469(1996)419;F.Karsch et al ,Phys.Lett.B 478(2000)447.2.See,e.g.,C.Zhai,B.Kastening,Phys.Rev.D 52(1995)7232,and references therein.3.K.Kajantie et al ,Phys.Rev.Lett.86(2001)10;Nucl.Phys.Proc.Suppl.106(2002)525.4. E.Braaten and A.Nieto,Phys.Rev.D 53(1996)3421.5.K.Kajantie etal ,Nucl.Phys.B 503(1997)357.6. A.D.Linde,Phys.Lett.B 96(1980)289;D.J.Gross et al ,Rev.Mod.Phys.53(1981)43.7.K.Farakos et al ,Nucl.Phys.B 442(1995)317;ine and A.Rajantie,Nucl.Phys.B 513(1998)471.8.G.D.Moore,Nucl.Phys.B 523(1998)569.。