Staurosporine_62996-74-1_DataSheet_MedChemExpress

P d t D t Sh t Product Name:
Staurosporine CAS No.:
62996-74-1Cat. No.:
HY-15141
Product Data Sheet
MWt:
466.53Formula:
C28H26N4O3Purity :>98%
Solubility:
DMSO
Mechanisms:
Biological Activity:
Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 Pathways:TGF-beta/Smad; Target:PKC nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
IC50 value:
Target: PKC The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of
staurosporine to the ATP-binding site on the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. This lack of specificity has precluded its clinical use, but has made it a valuable research tool. In
research sta rosporine is sed to ind ce apoptosis The mechanism of ho it mediates this is not References:
[1]. Matsumoto H, et al. Staurosporine, a protein kinase C inhibitor interferes with proliferation of
arterial smooth muscle cells. Biochem Biophys Res Commun. 1989 Jan 16;158(1):105-9.[2]Karaman MW et al A quantitative analysis of kinase inhibitor selectivity Nat Biotechnol 2008research, staurosporine is used to induce apoptosis. The mechanism of how it mediates this is not well understood. It has been found that one way in which staurosporine induces ...
[2]. Karaman MW, et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008
Jan;26(1):127-32.[3]. Chae HJ, et al. Molecular mechanism of staurosporine-induced apoptosis in osteoblasts.
Pharmacol Res. 2000 Oct;42(4):373-81.Caution: Not fully tested. For research purposes only
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