Extended Pasting Scheme for Kolam Pattern Generation

合集下载

A Century of Research on Rural Development and Regional Issues

A Century of Research on Rural Development and Regional Issues

A C ENTURY OF R ESEARCH ON R URAL D EVELOPMENTAND R EGIONAL I SSUESE LENA G.I RWIN,A NDREW M.I SSERMAN,M AUREEN K ILKENNY,AND M ARK D.P ARTRIDGERural North America has undergone a major economic transformation over the past century due tolabor-saving technological progress,reductions in transport costs,and rising household incomes.Theresults are greater rural economic diversity,selected rural population decline,increased rural–urbaninterdependence,emergent exurban areas,and amenity-led rural growth.We summarize key researchinsights and provide a selected review of the economics literature over the past100years with afocus on this economic transformation of rural places,its implications for rural communities,and keymodeling innovations and applications.The many important contributions by agricultural economistsare highlighted.Key words:rural economies,rural–urban interdependence,amenity-led growth,rural developmentpolicy,exurban,land use modeling,input-output models,computable general equilibrium.JEL codes:C67,C68,O18,R14,R23,R58.A discussion of rural and regional issues in economics requires a broadly cast net to capture the multiple areas of relevant inquiry: regional economics for its fundamental focus on subnational economic units;spatial economics for an understanding of the role of distance;rural and urban economics for their respective foci;and land economics for its study of land use and values.Economic geography encompasses all these concerns and thus provides a useful prologue.Simply, economic geography is about what happens where:Why dofirms and people tend to concentrate in a few locations rather than spread evenly across the countryside?What explains the variety of economic activities and land uses in a region?What are the economic Elena Irwin is associate professor at the Department of Agricul-tural,Environmental and Development Economics,Ohio State University:Andrew Isserman is a professor in the Departments of Agricultural and Consumer Economics and Urban and Regional Planning,University of Illinois;Maureen Kilkenny is a profes-sor of Resource Economics at the University of Nevada;and Mark D.Partidge is the Swank Chair in Rural-Urban Policy at the Department of Agricultural,Environmental and Develop-ment Economics,Ohio State University.We are grateful to David Barkley,Steve Deller,Tom Johnson,and David McGranahan for providing feedback on an earlier manuscript version of this article. The article benefited greatly from their excellent suggestions.In addition,we thank the following colleagues for their helpful review and comments on specific sections of the paper:Ralph Alig,Nancy Bockstael,Alessandra Faggian,Thomas Harris,Stanley Johnson, Davis Lewis,Gerald Nelson,David Newburn,Rose Olfert,Andrew Plantinga,Jack Stabler and stly,we thank DougWrenn and Heather Stephens for their research assistance.diversification prospects for low-population rural places that are costly to get to and from? As Samuelson(1983)noted in his article “Thünen at Two Hundred,”economic geogra-phy is not new.From the production location theory of von Thünen(1826/1966)to its fur-ther development by Weber(1929),Christaller (1933),Lösch(1940),Hoover(1948),and Isard (1956),a fundamental view has emerged of the importance of trade-offs among scale,trans-port costs,and endowments in explaining the economics of establishment location.Writing at midcentury,Hoover summarized these key insights in terms of three“foundation stones”:[A]n understanding of spatial andregional economic problems can bebuilt on three facts of life:(1)natural-resource advantages,(2)economiesof concentration,and(3)costs oftransport and communication.Inmore technical language,these foun-dation stones can be identified as(1)imperfect factor mobility,(2)imperfect divisibility,and(3)imper-fect mobility of goods and services.(Reprinted in Chapter1of Hooverand Giarratani1984)From the pioneering insights of Adam Smith on compensating wage differentials to theAmer.J.Agr.Econ.92(2):522–553;doi:10.1093/ajae/aaq008Received December2009;accepted January2010©The Author(2010).Published by Oxford University Press on behalf of the Agricultural and Applied Economics Association.All rights reserved.For permissions,please e-mail:journals.permissions@ at :: on April 22, 2011 Downloaded fromE.G.Irwin et al.A Century of Research on Rural Development and Regional Issues523more recent work of Tiebout(1956),and the theory of spatial equilibrium that emerged from the work of von Thünen(1826/1966), Alonso(1964),and other regional and urban economists,the important role of local pub-lic goods and amenities is a further elabora-tion of these“foundation stones”in explaining household and establishment location choices. The contributions of economists to research on rural and regional issues have been orga-nized around the study of these basic spatial economic processes and the implications for the evolution of rural places and for policies that seek to promote the vitality of these places(Castle1991).Agricultural economists in particular have made numerous contri-butions.In some cases,these contributions were foundational in terms of methods and empirical analyses.In other cases,the applied work of research and extension economists has resulted in pushing the boundaries of highly stylized conceptions of space and improving the usefulness of the models.This article provides a broad review of the economics literature on rural and regional economic issues over the past100years and highlights the important contributions by agri-cultural economists.While the focus is on contributions to these topics within agricul-tural economics,the discussion is necessarily broader,as many of the important theories and research developments have come from other areas,most notably regional science and urban economics.Our general approach is to identify so-called lessons from discernible lines of scholarship that summarize key insights in the evolution of the theoretical and applied research.We provide support for these sum-mary lessons by reviewing the intellectual her-itage of each line of scholarship(which often takes us outside the boundaries of agricultural economics)and then tracing the contributions within the agricultural economics literature. Obvious constraints imposed by a journal-length article necessitate an abbreviated dis-cussion of topics relevant to rural and regional issues.There is important work,some by agri-cultural economists,that regrettably has not been given its proper due here.In particular we note the omission of explicit discussions of rural poverty,endogenous growth,and human capital research.Other topics,while not dis-cussed in the research review,are lifted up as important topics in our concluding discussion of future research stly,with few exceptions,our review is of research on U.S. rural regions.Rural EconomiesRural people have made productive use ofthe vast natural resources as inputs for agri-culture,forestry,mining,and other primary production.However,over the past centuryrural North American economies have under-gone a major transformation fueled by labor-saving technological progress in agricultureand other natural resource industries(Simon 1947),reductions in transport costs,and rising incomes.The results include improved rural–urban income parity,farm population decline,and significant rural economic diversification.A comparison of the share of farm employ-ment in U.S.metropolitan and nonmetropoli-tan areas shows that in both cases,agriculture’sshare was over twofold greater in1969than in2007(figure1).The data suggest that even afterthe initial mechanization of farming had run its course,productivity growth still yielded fewerand fewer farm workers who were increas-ingly productive.This dramatic decline has affected even the most agriculturally intense places.For example,in describing the transfor-mation of the local economy in Saskatchewan, Canada,one of the most agriculturally inten-sive economies in North America,Stabler andOlfert(2009)report that the farm share of employment declined from60%in1931to8%in2008.Despite far fewer farmers,the nonfarm U.S.rural population has remained remarkably sta-ble over the century(figure2).At the turnof the twentieth century,the rural farm pop-ulation share was42%,the urban share was 35%,and the nonfarm rural share was23%.One hundred years later,the rural nonfarmshare remained nearly20%,but the rural farmshare had declined dramatically to about1% Figure1.Agricultural employment shares inmetropolitan and nonmetropolitan areasSource:U.S.Bureau of Economic Analy-sis,Regional Economic Information System. Available at ,accessed October15,2009.at :: on April 22, 2011Downloaded from524April2010Amer.J.Agr.Econ.Figure2.Percentage of U.S.urban,rural farm and rural nonfarm population,1890–2000 Source:U.S.Census Bureau;Census2000, Summary File3:generated using American Fact Finder;<http://factfi>; U.S.Census Bureau,1976;USDA-NASS,“Trends in U.S.Agriculture.”[da. gov/agency/nass/pubs/trends/farmpopulation. htm].(Kilkenny and Johnson2007).These dramatic shifts in farm employment and population have been accompanied by an increasing reliance of farm households on off-farm incomes.Recent data show that nearly89%of farm households’income was from nonfarm sources(USDA 2006),a shift that“has led many to observe that agriculture is far more dependent on the rural economy than the rural economy is on agriculture”(USDA2006).1The shifts in rural employment and pop-ulation reflect larger shifts in the national economy,including the expansion of employ-ment in services and a decline in the relative size of the manufacturing sector.In fact,many rural areas benefited particularly during the 1970s and1980s due to technological change and the relocation of manufacturing into rural areas.Other rural areas have benefited from the reductions in transportation and commu-nication costs that have increased the accessi-bility of rural places with high-valued natural 1Rural definitions differ depending on the data source and research question at hand.For example,using data from the U.S. Census Bureau,as in Figure2,urban is defined as consisting of built-up areas with more than2,500people,and rural as everything else. Alternatively,the Office of Management category of non-core iden-tifies counties without any urban areas of10,000people or more and with limited or no commuting to such towns or larger cities else-where.Micropolitan identifies counties with urban areas of10,000 to49,999and surrounding counties linked to them through strong commutingflows,leaving as metropolitan counties with urban areas of50,000or more and their surrounding areas linked through com-muting.Therefore,nonmetropolitan,which combines micropolitan and non-core counties as in Figure1,includes a variety of land-scapes ranging from small cities and their commuting sheds to some 1,084counties that have no built-up areas of even2,500people.In 2000the nonmetropolitan counties had20million residents living in urban areas and29million living in settlements with fewer than 2,500people or in the country.See Isserman(2005)for a detailed discussion of these definitions,the constraints on research choices, and their implications.amenities and made them desirable residential destinations for retirees,tourism-related busi-nesses,and service sectorfirms.Rural areasare also home to those who are attracted bya rural lifestyle and lower land and housingprices and are willing to commute to cities for employment.Today,rural areas are exceedingly diversein terms of economic activity and employ-ment.Farming(6%),mining,forestry,andfishing(<2%),and manufacturing(11%)pro-vide about one-fifth of nonmetropolitan jobs.Two-fifths are typical town functions:retailtrade(12%),health care and social ser-vices,(9%),accommodation and food services (7%),professional and technical services(3%),finance and insurance(3%),real estate andrental/leasing(3%),and wholesale trade(3%).Local government(10%)and state and federal government(6%)add another sixth.The bal-ance comprises construction(7%),transporta-tion and warehousing(3%),and miscellaneous services(15%).A USDA(2005)typologyof nonmetropolitan counties based on indus-try thresholds underscores how diverse rural economies really are:585are manufacturing dependent,403are farming dependent,222are government dependent,114are services dependent,113are mining dependent,and615are nonspecialized nonmetropolitan counties.These initial observations of some of the fun-damental economic forces that have shapedrural economies over the past century lead usto ourfirst lesson concerning the contributionsof agricultural economists to research on rural economies.Lesson#1:The rural economy is no longera farm economy.The idea that“rural”is no longer just“farm”would have sounded alien to most agricul-tural economists in1950.Farming engagedthe majority of rural people until the1940s(figure2).It was thus understandable thatexport base theory,which contends that a region’s growth is led and determined byexport demand in the context of perfectly elas-tic factor supplies,was the widely acceptedview of rural growth(North1955,1956,1959). Traditional economic base models would have predicted a complete collapse of the nonfarmrural economy as a result of the sustained decline of the agriculture export base employ-ment since midcentury,but that collapse didnot happen(Kilkenny and Partridge2009). Instead,the share of nonfarm rural populationat :: on April 22, 2011Downloaded fromE.G.Irwin et al.A Century of Research on Rural Development and Regional Issues525remained remarkably constant(figure2)due to manufacturing and service sector employ-ment growth.This is prima facie evidence that the farm sector is not the sole determinant of the rural economy.While few mid–twentieth century econo-mists disputed the notion that agriculture and natural resource industries were dominant, many were not inclined to assert that it would be the engine of future growth.Hoover(1948), for example,referred to areas that depended on agriculture,hunting,fishing,and other natu-ral resource–based activities as“primitive.”He pointed out that because food’s share of the budget declines with rising incomes(Engel’s law),industrialized areas would grow faster as incomes rise,while agriculture-dependent areas would grow slower.The emergence of auto transport by the mid–twentieth century meant that commuting to urban employment was becoming a major mode by which rural people and communi-ties engaged with nonfarm urban economies. Schultz(1950,1953)argued that urban agglom-eration effects extended far into the country-side.Rather than land quality,accessibility to urban markets was the key factor in the pros-perity of rural regions.Ruttan(1955)found that the median income of farm families was related to the level of urban-industrial devel-opment in the area and that increased avail-ability of off-farm jobs to farm family members was more important than increased labor pro-ductivity in agriculture in raising farm family incomes.Fox and Kumar(1965)described how urban commuting created functional economic areas that extended50miles out from cities of25,000or more people in Iowa.As they stated,“[We]are dealing with people-oriented rather than resource-oriented regions”(p.62) [emphasis added].They pointed out that even the rural peripheries of functional economic areas were increasingly dependent on anchor urban areas.Due to their historical focus on the farm sector,Fox(1962)noted that“[a]few years ago only a handful of agricultural economists had much proficiency in interpreting interac-tions between agriculture and the non-farm economy”(p.3).Noting“our tendency to equate farms with farmers and farmers with rural communities,”Bishop(1967)asked in an address as president of the American Farm Economic Association(AFEA):“Surely,the problems involved are as important to rural people as changes in the structure of farm-ing.Why have agricultural economists not devoted more resources to the study of struc-tural changes in rural communities and to pub-lic policies relating to the location of economic activities and of population?”Years later, Pulver and Rogers(1986)studied nonfarm income in farm-dependent counties and rec-ommended that rural development policyfocus both on farm incomes,prices,and pro-duction and on vitality of the nonfarm rural economy:“The survival of rural Americanfarms and rural communities depends equallyon the expansion of nonfarm income and employment opportunities in rural areas”(pp.1186–7).By the1970s,the notion that rural wasnot agricultural alone had become the domi-nant view among agricultural economists.As Edwards(1981)explained:Most of the rural economy in theUnited States is a nonfarm economy.Rural growth is not the equivalentto agricultural growth.In fact,techni-cal progress in agriculture can releaseredundant agriculture labor into thenearby nonfarm rural economy andhave a depressing rather than a stim-ulating effect.A growing commercialagriculture may have closer economicties with the highly developed urbaneconomy,where it sells products andpurchases inputs,than with the spatialcontiguous rural nonfarm economy.(pp.223–224)Today,agricultural and regional economists emphasize the economic diversity of rural places and do not associate long-term place prosperity with static notions of sector prosper-ity(Barkley1993;Isserman2001;Johnson1997, 2007).This conclusion is supported by a varietyof empirical evidence of the wide and varied economic contributions of rural areas.Smith (1984)and Porterfield and Pulver(1991)used surveys of businesses to demonstrate that ser-vices and other nonmanufacturing businesses export from rural areas.Therefore,in Smith’s words,“They can reasonably be includedwith manufacturing in employment genera-tion and economic development programs”(p.153).Similarly arguing that the narrow focus on goods-producing industries needs to be reex-amined,Stabler and Howe(1988)found that “there can be no doubt that exports of servicesmade a substantial contribution to the growthat :: on April 22, 2011Downloaded from526April2010Amer.J.Agr.Econ.of the four western Canadian provinces dur-ing the1970s”(p.312).Feser and Isserman (2009)provide the latest evidence of rural eco-nomic diversity by focusing on national value chains.They identify45national value chains, and using a two-way county taxonomy that considers population distribution and density (urban,mixed urban,mixed rural,and rural) as well as metropolitan–nonmetropolitan sta-tus(Isserman2005),theyfind that rural non-metropolitan counties specialize in28of these 45chains.While many of those value chains are agriculture-or primary sector–based,such as feed products,wood processing,and min-ing,rural specialties also include appliances, construction machinery,motor vehicles,and machine tools.These shifts have affected even the most agriculturally intensive rural places. Stabler and Olfert(2009)report that mod-ern rural Saskatchewan can be described as follows:Inputs used in agriculture are nowpurchased from all over the worldrather than in the nearest town.But even as the industrial linkagesbetween the agricultural industryand the rest of the rural econ-omy have eroded,a mutual depen-dence between rural and urbanSaskatchewan has developed.Thetwo have become integrated as neverbefore through rural dwellers com-muting to a few large communities foremployment,to shop and to accesspublic services.It is as if all of ruralSaskatchewan has become a geo-graphically removed neighbourhoodof an urban center.(emphasis added) These trends of increased accessibility,spa-tial contiguity with expanding urban areas, rising incomes,preferences for amenities,and diversification of rural economies leads to our next lesson on rural economies.Lesson#2:“Rural”vs.“urban”is more than a simple dichotomy.There is a strong interdependence that produces a continuum from dense urban places to remote rural places. Distinctions between rural and urban aptly characterized the economic landscape for most of civilization.Before the Industrial Revolu-tion,high transport costs and the relatively low productivity of farmers limited popula-tion densities and the extent of urbanization.Less than10%of a region’s population couldbe sustained in cities,and even the largestcities(outside of Asia’s more dense rice-based civilizations)were concentrations of no morethan150,000people(Bairoch1988;McEvedy 1992).Beginning in the nineteenth century,the Industrial Revolution produced a number of technological innovations in production and transportation that shifted production from thehomes to large bor-saving tech-nologies in agriculture and scale economiesin manufacturing fueled large-scale rural-to-urban migration and the emergence of manylarge and medium-sized industrial cities.Inno-vations in transit,including electric trolleysin the1890s and automobiles in the1910s, decreased the cost of intra-city transportionand led to city expansion into the countryside.The extent of the city was nonetheless discrete,with the open countryside typically beginningright where the city ended.These clear distinctions between rural andurban began to blur during the twentieth century with the continued rise in agricul-tural productivity,the greatly reduced costsof transporting farm products that put thewhole United States within any one farm’s market area,and the reduced costs of com-munication and commuting.After World WarII the pattern changed dramatically:Urban-ization slowed,extensive road networks mademany once-remote places accessible,and pop-ulation and production decentralized,leadingto urban“sprawl”and exurban development.Most counties since the1980s have containedboth rural and urban areas and are home tomany of the economic functions that previouslyhad occurred only in cities.Formal modeling of the numbers and spatial extents of the smallest to largest cities in theurban hierarchy was advanced by Christaller (1933)and Lösch(1940).Their Central Place Theory(CPT)explains the sizes,distances between,and sectoral compositions of cities, including towns in agricultural areas such asthe Great Plains(Olfert and Stabler2002).Amajor advantage of CPT is its realism in mea-suring actual business and consumer servicesand their population thresholds(i.e.,the popu-lation that is needed to support given servicessuch as a grocery store).The primary criti-cism of CPT is that it is static,requiring adhoc assumptions regarding changes in tech-nology and transportation costs to make it dynamic.CPT generated great interest among agricultural economists of rural developmentat :: on April 22, 2011Downloaded fromE.G.Irwin et al.A Century of Research on Rural Development and Regional Issues527beginning in the1950s.The declines in com-munication and transportation costs led to rising population thresholds,which in turn led to the consolidation of some private service industries in larger urban centers(Stabler and Olfert2002).This provided increased pressure to consolidate government jurisdictions,which previously reflected the needs of a nineteenth-century agrarian economy(Allen1931;Fox and Kumar1965).CPT also motivated regionwide economic development policies for functional economic areas surrounding larger urban centers of 25,000people or more.Myrdal(1957)intro-duced the concepts of“spread”effects,in which growth diffuses to rural hinterlands through demand for agricultural products and raw materials,leading(if successful)to“new cen-ters of self-sustained economic expansion”(p.31).But interdependence with the core could also be destructive.Myrdal called“backwash”effects those in which urban growth attracts people and capital away from the hinterlands. For further discussion of the positive and neg-ative dependence of rural areas on their urban centers,see the reviews by Gaile(1980)and Parr(1999a,1999b)and the critical prescrip-tions for regional prosperity by Jacobs(1984). The conceptual strength of the growth-center model led to support for urban growth-center policy,as well as a debate about rural participation in urban-led growth processes (Day1968).Growth prospects being better for towns of sufficient size justifies targeting investment of scarce resources to towns with critical mass.Efficient government funding should target places promising higher returns. Proponents of strategic investment in growth centers argued that a“worstfirst”policy of providing funds to the smallest and poorest communities would be ineffective because they lacked the scale economies needed to sus-tain growth(Berry1970;Hansen1970).They supported targeting intermediate-sized cities ranging from50,000to250,000(Berry)or even 1million in population(Hansen).On the other hand,agricultural economists argued that rural regions should have greater participation in the regional and national growth process and that targeted growth centers could be much smaller. Tweeten and Brinkman(1976)suggested that a city size of10,000people was large enough. The Appalachian Regional Commission desig-nated even market towns and service centers of5,000to7,000as centers,pointing out they serve rural areas of250,000or more(Isserman and Rephann1995).Despite the initial enthusiasm for regional approaches,research in CPT,regionalization,and growth centers waned in the1970s formany reasons.First,in the absence of modern geographic information systems(GIS)thathave greatly facilitated large data sets and detailed spatial analysis,descriptive empiri-cal analyses were limited,which prevented researchers’ability to empirically test CPT hypotheses.Second,migration into ruralareas led to the so-called rural renaissanceor“population turnaround,”in which non-metropolitan growth outpaced metropolitan growth for thefirst time in the1970s,especiallyto high-amenity rural areas(Bishop1967; Beale1975,1977).With rural America’s prospects improved,the major institutional change needed to coordinate a growth-centerpolicy that engaged rural communities wasless urgent.Third,though rural towns lacked capacity to unilaterally plan and conduct eco-nomic development programs,a regionwide scope was opposed by rural interests that feared the loss of political self-determination (Whisnant1994).Fourth,as the Appalachian Regional Commission found,formidable pressure against growth poles comes fromofficials whose areas are not designated and, thus,are ineligible for funds(Isserman and Rephann1995).Afinal reason for the waning interest inCPT was a frustration arising from the lack of economic progress in rural areas near growth centers(Whisnant1994).It appeared that therural population decline was mainly the con-sequence of urban growth’s counterproduc-tive“backwash”effects.Proponents of growth-center policy responded that it takes morethan a few years of modest investments to rejuvenate entire regions(Richardson1976). Urban growth was also blamed for the “rural brain-drain,”in which the highest-skilledwere especially likely to leave.Schultz(1950, 1953),Sjaastad(1962),Huffman(1977,1980), Tweeten and Brinkman(1976),Topel(1986), Barkley(1990),and many others have docu-mented the“pull”effect of the relatively higherurban returns to human capital.Others arguedthat infrastructure policy that supported rural commuting to growth centers simply encour-aged more out-migration by increasing rural residents’familiarity with urban locations (Jansma et al.1981).Following a relative dearth of research onrural–urban linkages for a couple of decades,the topic received renewed attention in the1990s as exurban sprawl increasingly fueledat :: on April 22, 2011Downloaded from。

跨文化交际理论主要参考书目

跨文化交际理论主要参考书目

跨文化交际理论主要参考书目LT跨文化交际理论主要参考书目Abrams, D.&Hogg, M. A. (eds.). Social Identity Theory: Constructive and Critical Advances, New York: Springer-Verlag New York, Inc., 1990.Ajzner, J. “Some problems of rationality, understanding, and universalistic ethics in the context of Habermas’s theory of communicative action”, in Philosophy of the Social Science, 1994,24, pp.468-474. Anderson, B. Imagined Communities (second edition), Lodon: Verso, 1991. Arasaratnam, L. A. & Doerfel, M. L. “Intercultural communication competence: in International Journal of Intercultural Relations, 2005, 29, pp. 137-142.Asher, H. B. et al.Theory-Building and Data Analysis in the Social Sciences, Knoxville: The University of Tennessee Press, 1984. Babbie, E.The Practice of Social Research, Beijing: Tsinghua University Press, 2003. Baghramian, M. & Ingram, A. (eds.) Pluralism:the Philosophy and Politics of Diversity, New York: Routledge, 2000.Ball, T. “From paradigms to research Program: Toward a post Kuhnian political science”, in H. B. Asher at al. (eds.) Theory Building and Data Analysis in the Social Sciences, Knoxville: The University of Tennessee Press, 1984, pp. 23-43. Beiner, R. et al. (eds.). Canadian Political Philosophy, New York: Oxford University Press, 2001.Benet-Martinez, V. et al. “Biculturalism and cognitive complexity: Expertise in cultural representations”, in Journal of Cross-Cultural Psychology, 2006, 37, pp. 368-407.Bennett, M. “T owards ethnorelativism: A development model of intercultural sensitivity”, in M. Paige (ed.).Education for the Intercultural Experience (second edition) , Yarmouth: Intercultural Press, 1986.Burgoon, J. K. “Interpersonal expectancy violations, and emotional communication”, in Journal of Language and Social Psychology, 1993, 12, pp. 30-48.Burgoon, J. K. “Cross-cultural and intercultural applications of expectancy violation theory”, in R. L. Wiseman (ed.), Intercultural Communication Theory, Thousand Oaks: Sage Publications, 1995, pp. 194-214.Burgoon, J. K. and Hubbard, A. S. E. “Cross-cultural and intercultural application of expectancy violation theory and interaction adaptation theory”, in W.B. Gudykunst (eds.).Theorizing about Intercultural Communication, Thousand Oaks: Sage, 2005, p. 164, pp. 161-166. Burns, E. M. Western Civilizations (eighth edition) (Vol.1), New York: W. W. Norton &Company, Inc., 1973.Carnoy, cation as Cultural Imperialism, New York: David McKay Company,Inc., 1974.Charon, J. M. Symbolic Interactionism: An Introduction, an Interpretation, an Integration, Upper Saddle River: Prentice-Hall, Inc., 1998.Chen, G. M. “Intercultural communication competence: Some perspectives of research”, in The Howard Journal of Communications,1990, 2, pp. 243-261. Chen, G. M. &Starocta, W. J. “I ntercultural communication competence: A synthesis”, in Communication Yearbook, 19, 1996, pp. 353-383.Chen, G. M. &Starocta, W. J. Foundations of Intercultural Communication, Boston: Allyn & Bacon, 1998.Chen, G. M. &Starocta, W. J. (eds). Communication and Global Society, New York: Peter Lang, 2000.Chen, G. M. “Toward transcultural understanding: A harmony theory of Chinese communication”, in V. H. Milhouse et al.(eds). Transcultural Realities: Interdisciplinary Perspectives on Cross-cultural Relations, 2001, Thousand Oaks: Sage Publications, pp.55-70. Chen, G. M. “A model of global communication competence”, in China Media Research, 2005, 1, pp. 3-11.Chen, G. M. “Asian communication studies: What and where to now”, in The Review of Communication, 2006, 6, pp. 295-311. Chen, L. “Interaction involvement and partners of topical talk: A comparison of intercultural and intracultural dyads”, in International Journal of Intercultural Relations, 19, 1995, pp.463-482. Christian, C. & Traber, M. (eds.). Communication Ethics and Universal Values, Thousand Oaks: Sage Publications, 1997. Chomsky, N. On Nature and Language, Beijing: Peking University Press, 2004.Condon, J. C. &Yousef, F. An Introduction to Intercultural Communication, Indianapolis:Bobbs-Merrill, 1975.Cornell, S. &Hartman, D. Ethnicity and Race: Making Identities in a Changing World, Thousand Oaks: Pine Forge Press, 1998. Craig, R. T. & Tracy, K. “Grounded practical theory: The case of intellectual discussion”, in Communication Theory, 1995, 8, pp. 248-254.Craig, R. T. & Muller, H. L. (eds). Theorizing Communication, Thousand Oaks: Sage Publications, 2007.Crain, S. “The interpretation of disjunction in universal grammar”, in Language ans Speech, 2008, 51(1&2), pp.152-169.Cronen, V. E. “Practical theory, practical art, and the pragmatic-systemic account of inquiry”, in Communication Theory, 2001, 11, pp.14-34.Cryderman, B. et al. (eds). Police, Race and Ethnicity: A Guide for Law Enforcement, Toronto: Butterworth &Co. (Cananda) Ltd.,1986.Cupach, W. R. & Imahori, T. “Identity management theory: Communication competence in intercultural episodes and relationships”, in R. L. Wiseman& J. Koester (eds.). Intercultural Communication Competence, Newbury Park: Sage, 1993, pp. 112-131.Dascal, M. (ed.). Cultural Relativism and Philosophy, New York: E. J. Brill, 1991. Delgado-Moreira, J. M.Multicultural Citizenship of the European Union, Aldershot: Ashgate Publishing Limited, 2000.Doan, G. O. & Stephan, C. W. “The fuctions of ethnic identity: A New Mexico Hispanic example”, in International Journal of Intercultural Relations, 2005, 29, pp. 229-241.Dodd, C. H. Dynamics of Intercultural Communication, Madison: Brown & Benchmark, 1977.Dodd, C. H. Dynamics of Intercultural Communication(fifth edition), Shanghai Foreign Language Teaching Press, 2006. Duranti, A. (ed.).Key Terms in Language and Culture, Malden: Blackwell Publishers, 2001.Duranti, A. Linguistic Anthropology, Beijing:Beijing University Press, 2002. Duronto, P. M. et al. “Uncertainty, anxiety, and avoidance in communicating with strangers”,in International Journal of Intercultural Relations, 2005, 29, pp. 540-560.Earley, P. C. Face, Harmony, and Social Support: An Analysis of Organizational Behavior across Cultures, New York: Oxford University Press, 1997.Ellis, J. M. Language, Thought, and Logic, Evanstom: Northwestern University Press, 1993.Erman, E. “Reconciling communicative action with recognition: Thickening the‘inter’of intersubjectivity”, in Philosophy and Social Criticism, 2006, 32, pp. 377-400.Evanoff, R. J. “Universalist, relativist, and constructivist approaches to intercultural ethics”,in International Journal of Intercultural Relations, 2004, 28, pp. 439-458.Foley, W. A. Anthropological Linguistics, Beijing: Foreign Language Teaching and Research Press, 2001.Freud, S.Interpretation of Dreams, Beijing: Foreign Language Teaching and Research Press.Ge, G. “Book review on The Challenge of Facebook: Cross-Cultural and Interpersonal Issues”, in International Journal of Intercultural Relations, 1995, 19, PP.455-462.Ge, G. “An initial analysis of the effects of face and concern for ‘other’in Chinese interpersonal communication”, inInternational Journal of Intercultural Relations , 1998, 22, pp.467-482. Geertz, C. Local Knowledge: Further Essays in Interpretive Anthropology, New York: Basic Boks, 1993.Geertz, C. Available Light: Anthropological Reflections on philosophical Topics, Princeton: Princeton University Press, 2000.Giddeds, A. The Consequenced of Modernity, Stanford: Stanford University Press, 1990. Giles, H.& Noels, K. A. “Communication accommodation in intercultural encounters”, in J. N. Matin at al. (eds.). Readings in Cultural Contexts, Mountain View: Mayfeild Publishing Company, 2002. Glazer, N. et al. (eds.). Ethnicity: Theory and Experience, Cambridge: Harvard University Press, 1975.Goffman, E. Interaction Ritual: Essays on Face-to-Face Behavior, New York: Pantheon Books, 1967.Gorton, M. M. Assimilation in American Life: The Role of Race, Religion, and National Origion, New York: Oxford University Press, 1964.Grace, G. W. The Linguistic Construction of Reality, New York: Groom Helm, 1987. Gudykunst, W. B. (ed.).Intercultural Communication Theory: Current Perspectives, Beverly Hills, Sage Publications, 1983. Gudykunst, W. B. “Anxiety/ uncertainty management(AUM) theory”in R. L. Wiseman(ed.). Intercultural Communication Theory,Thousand Oaks: Sage Publications, Inc., 1995, pp.8-58.Gudykunst, W. B. “Applying anxiety/ uncertainty management(AUM) theory to intercultural adjustment training”, in International Journal of Intercultural Relations, 1998, 22, pp.227-250. Gudykunst, W. B.& Nishida, T. “Anxiety, uncertainty, and perceiced effectiveness of communication across relationships andcultures”, in International Journal of Intercultural Relations, 2001, 25, pp.55-71.Gudykunst, W. B.& Mody, B. (eds). Handbook of International and Intercultural Communication (second edition), Thousand Oaks: Sage Publications, Inc., 2002. Gudykunst, W. B. (ed.). Cross-Cultural and Intercultural Communication, Thousand Oaks: Sage Publications,2003.Gudykunst, W. B. &Kim, Y. Y. Communicating with Strangers: An Approach to Intercultural Communication (forth edition), New York: The McGraw-Hill Companies, Inc., 2003.Gudykunst, W. B. (ed.). Theorizing about Intercultural Communication, Thousand Oaks: Sage Publications, Inc.,2005.Guibernau, M. “National identity and modernity”, in A.Dieckoff& N. Gutierrez(eds.). Modern Roots: Studies of National Identity, Aldershot: AshgatePublishing Limited, 2001.Gullahorn, J. T. & Gullahorn J. E. “An extension of U-curve hypothesis”, in Journal of Social Issues, 1963, 19, pp.33-47.Gupta, C. & Chattopadhyaya, D. P. (eds.). Cultural Otherness and Beyond, Leiden: Brill, 1998.Habermas, J, Communication and the Evolution of Society(translated by T. McCarthy), Boston: Beacon Press, 1976. Habermas, J,On the Pragmatics of Communication( translated by M. Cook), Cambridge: The MIT Press, 1998.Hall, E. T. The Silent Language, Garden: Doubleday, 1959.Hall, E. T. The Hidden Dimension, Garden City: Doubleday, 1966.Hall, E. T. Beyond Culture, Garden City: Doubleday, 1976.Halliday, M. A. K. “Language and social man”, in J. J. Webster(ed.). Language andSociety, Beijing: Peking University Press, 2007, pp.65-130.Hampden-Turner, C. &Trompenaars, F. “Response to Geert Hofstede”, in International Journal of Intercultural Relations, 1997, 21, pp.149-159.Hatch, E. Theories of Man and Culture, New York: Columbia University Press, 1973. Hattie, J. Self-Concept, Hillsdale: Lawrence Erlbaum Associate, Publishers, 1992.Hawes, L. C. Pragmatics of Analoguing: Theory and Model Construction in Communication, Melo Park: Addison-Wesley Publishing Company, 1975.Hickmann, M. “Linguistic relativity and linguistic determinism: Some new directions”, in Linguistic, 2000, 38, pp. 409-434.Ho,D. Y. “On the concept of face”, in American Journal of Sociology, 1976, 81, pp. 868-884.Hofstede, G. Cultures and Organizations: Software of the Mind, Maidenhead: McGraw-Hill Book Company, 1991. Hofstede, G. Culture’s Consequences: Comparing Values, Behaviors, Institutions and Organizations across Nations, Thousand Oaks: Sage Publications, Inc., 2001. Hudson, R. A. Socialinguistics, Beijing: Foreign Language Teaching and Research Press, 2000.Hymes, D. “Two types of linguistic relativities”, in W. Bright (ed.). Sociolinguistics: Proceedings of the UCLA Sociolinguistics Conference, Hague: Mouton, 1966.Jandt, F. E. An Introduction to Intercultural Communication: Identities in a Global Community( fourth edition), Thousand Oaks: Sage Publications, 2004. Jia, W. The Remaking of the Chinese Character and Identity in the 21th Century, Westport: Ablex Publishing, 2001.Kaplan, A. The Conduct of Inquiry: Methodology for Behavioral Science, San Francisco: Chandler Publishing Company, 1964.Kim, Y. Y. “Toward an interactive theory of communication acculturation”, in D. Nimmo( ed.). Communication Yearbook 3, New Brunswick: Transaction, 1979, pp. 435-453. Kim, Y. Y.&Gudykunst, W. B. (eds.). Cross-Cultural Adaptation: Current Approaches, Newbury Park: Sage Publications, Inc.,1987.Kim, Y. Y.&Gudykunst, W. B. (eds.). Theories in Intercultural Communication, Newbury Park: Sage Publications, Inc., 1988. Kim, Y. Y. Becoming Intercultural: An Integrative Theory of Communication and Cross-Cultural Adaptation, Thousand Oaks: Sage Publications, Inc., 2001.Kim, Y. Y. “Intercultural personhood: Globalization and a way of being”, in International Journal of InterculturalRelations,2008, 32, pp. 359-368. Klyukanov, I. E. Principles of Intercultural Communication, Boston: Pearson Education, Inc., 2005.Kottak, C. P. Cultural Anthropology (ninth edition), New York: McGraw-Hill Higher Education, 2002.Kuhn, T. The Structure of Scientific Revolution. Chicago: University of Chicago University Press, 1970.Llayder, D. Social and Personal Identity: Understand Yourself, Thousand Oaks: Sage Publications, 2004.Littlejohn, S. W. Theories of Human Communication (seventh edition), Beijing: Tsinghua University Press, 2003. Lusting, M. W. & Koester, J. I ntercultural Competence: Interpersonal Communication across Cultures(fourth edition), Boston: Allyn and Bacon, 2003.Lyon, J. Language and Linguistics: An Introduction, Cambridge: CambridgeUniversity Press, 1981.Marger, M. N. Race and Ethnic Relations: American and Global Perspectives(fifth edition), Belmont: Wadsworth, 2000. Markus, H. R. & Kitayama, S. “Implications for recognition, emotion and motivation: Culture and the self”, in Psychological Review, 1991, 98, pp. 224-253.Markus, H. R. & Kitayama, S. “The cultural psychology of personality”, in Journal of Cross-Cultural Psychology, 1998, 29, pp. 63-87.Marsella, A. J. et al. (eds.). Culture and Self: Asian and Western Perspectives, New York: Tavistock Publication, 1985. Martin. J. N. &Nakayama, T. K I ntercultural Communication in Contexts( second edition), Mountain View: Mayfield Publishing Company, 2000.Martin. J. N. et al. (eds.). Readings in Cultural Contexts, Mountain View: Mayfield Publishing Company, 2002.May, S. “Language rights: Moving the debate forward”, in Sociolinguistics, 2005,9, pp. 319-321.McLaren, M. C. Inetrpreting Cultural Difference: The Challenge of Intercultural Communication, Dereham: Peter Francis Publishers, 1998.Mead, G. H. Mind, Self, &Society: From the Standpoint of a Social Behaviorist, Chicago: The University of Chicago Press, 1967. Miike, Y. “Theorizing culture and communication in the Asian context: An assumptive foundation”, in Intercultural Communication Studies, 2002, 11, pp. 1-12. Miike, Y. “Non-western theory in western research? An Asiacentric agenda for Asian communication studies”, in The Review of Communication, 2006, 6, pp. 4-31.Miller, D. Citizenship and National Identity, Cambridge: Polity Press, 2000. Mowlana, H. Global Communication in Transition?, Thousand Oaks: Sage, 1996.Murray, S. O. American Sociolinguistics: Theories and Tteory Groups, Peking University Press, 2004.Navas, M. et al. “Relative acculturation extended model”, in International Journal of Intercultural Relations,2005,29, pp. 21-37.Neuliep, J. W.Intercultural Communication: A Contextual Approach, Boston: Houghton Mifflin Company, 2000.Nevitte, N. &Kornberg, A.(eds.). Minorities and the Canadian State, Oakville: Mosaic Press, 1985.Nishida, H. et al. “Cognitive differences between Japanese and Americans in their perceptions of difficult social situations”, in Journal of Cross-Cultural Psychology, 1998, 29, pp. 499-524. Nishida, H. “A cognitive approach to intercultural communication based on schema theory”, in International Journal of Intercultural Relations, 1999, 23, pp.753-777.Oberg, K. “Cultural shock: Adjustment to new cultural environments”, in Practical Anthropology, 1960, 7, pp. 177-182. Oliver, R. T. Culture and Communication, Springfield: Thomas, 1962.Padilla, A. (ed.). Acculturation: Theory, Models and Findings, Boulder: Westview, 1980.Pearce, W. B. & Pearce, K. A. “Extended theory of the coordinated management of meaning (CMM) through a community dialogue process”, in Communication Theory, 2000, 10, pp. 405-423.Phillipson, R. Linguistic Immperialism, Shanghai: Shanghai Foreign Language Education Press, 2000.Picco, G. et al(eds.). Crossing the Devide: Dialogue among Civilizations, South Orange: School of Diplomacy and International Relations & Seton Hall University, 2001. Prosser, M. Cultural Dialogue, Boston:Houghton Miffilin.Prus, R. Symbolic Interactionism and Ethnographic Research: Intersubjectivity and the Study of Human Lived Experiences, Albany: State University of New York Press, 1996.Rescher, N. Rationally: A Philosophical Inquiry into the Nature and the Rationale of Reason, Oxford: Clarendon Press, 1988. Robins, R. H. A Short History of Linguistics (third edition), Lodon: Longman Group UK Limited, 1990.Samovar, L. A. &Porter, R. E. (eds.).I ntercultural Communication: A Reader, Belmont: Wadsworth, 1972.Samovar, L. A. et al. Communication between Cultures(third edition), Beijing: Foreign Language Teaching and Resaerch Press, 2000. Schiller, H. Mass Communications and American Empire, New York: Augustus M. Kelly, 1969.Schiller, H. Communication and CulturalDominance, New York: International Arts and Sciences Press, 1976.Schutz, A. The Phenomenology of the Social World( translated by G. Walsh et al.), Chicago: Northwestern University Press, 1967.Searle, J. R. The Construction of Social Reality, New York: The Free Press, 1995. Severin, W. J. &Tankard, J. W. Jr Communication Theories: Origins, Methods, and Uses in the Mass Media( fourth edition), New York: Longman Publishers, 1997. Smith, A. D. National Identity, Las Vegas: University of Nevada Press, 1991.Smith, L. R. “Intercultural network theory: A cross-paradigmatic approach to acculturation”, in International Journal of Intercultural Relations, 1999, 23, pp. 629-658.Smith, M. J. Contemporary Communication Research Metheods, Belmont: Wadsworth Publishing Company, 1988.Splinder, G. D. Sociological and Psychological Processes in Menomini Acculturation, Berkley: University of California Press, 1955.Spiro, M. E.“The acculturation of American ethnic groups”, in American Anthropology, 1955, 57, pp. 1240-1252.Steinfatt, T. M. “Linguistic relativity: Toward a broader view”, in S. Ting-Toomey and F. Korzenny(eds.). Language, Communication, and Culture: Current Directions, Newbury Park: Sage Publications, 1989.Tajfel, H. et al. “ Social categorization and intergroup behavior”, in European Journal of Social Psychology, Vol.1, 1971, pp. 149-178.Tajfel, H. (ed.). Social Identity and Intergroup Relations, London: Cambridge University Press, 1982.Ting-Toomey, S. “Towards a theory of conflict and culture”, in W. B. Gudykunst& S. Ting-Toomey (eds.). Communication, Culture, and Organizational Processes, Beverly Hills: Sage, 1985, pp. 71-86.Ting-Toomey, S.& Korzenny, F. (eds.). Cross-Cultural Interpersonal Communication, Newbury Park: Sage Publications, Inc., 1991.Ting-Toomey, S.& Kurogi, A. “Facework competence in intercultural conflict: An updated face-negotiation theory”, in International Journal of Intercultural Relations, 1998, 22, pp. 187-225.Ting-Toomey, S. Communicating across Cultures, New York: The Guilford Press, 1999.Ting-Toomey, S. “Intercultural conflict competence”, in W. R. Cupach& D. J. Canary (eds.). Competence in Interpersonal Conflict, New York: McGraw-Hill, 1997, pp. 120-147.Ting-Toomey, S.& Oetzel, J. G. Managing Intercultural Conflict Effectively,Thousand Oaks: Sage Publications, Inc., 2001.Tomlinson, J. Cultural Imperialism: A Critical Introduction, Baltimore: Johns Hopkins University Press, 1991. Tomlinson, J. Globalization and Culture, London Polity Press, 1999.Triandis, H. C. Individualism and Collctivism, Boulder: Westview, 1995. Tsukuba, Y. “English hegemony and English divide”, in China Media Research, 2008, 4, pp. 47-55.Tu, W. Conflict Thought: Selfhood as Creative Transformation, New York: State University of New York Press, 1985. Vago, J. M. (ed.). Culture Bound, Cambridge: Cambridge University Press, 1986. Ward, C. “Thinking outside Berry boxes: New perspectives on identity, acculturation and intercultural relations”, in International Journal of Intercultural Relations, 32, 2008, pp. 105-114.White, S. K. (ed.). The Cambridge Companion to Habermas, Beijing: SDX Joint Publishing Company, 2006.Willett, C. (ed.). Theorizing Multiculturalism: A Guide to the Current Debate, Malden: Blackwell Publishers Ltd., 1998.Williams, R. Keywords: A Vocabulary of Culture and Society, London: Fontana Press, 1983.Wiseman, R. L. (ed.).Intercultural Communication Theory, Thousand Oaks: Sage Publications, Inc.,1995.Wood, J. T. Communication Theories in Action: An Introduction (second edition), Belmont: Wadsworth, 2000.Worchel, S. “Culture’s role in conflict and conflict management: Some suggestions, many questions”, in International Journal of Intercultural Relations, 2005, 29, pp. 739-757.Xiao, X. “Zhong (centrality): Aneverlasting subject of Chinese discourse”, in Intercultural Communication Studies, 2003, 12, pp. 137-149.Yang, R. P. et al. “Multiple routes to cross-cultural adaptation for international students: Mapping the paths between self-construals, English language confidence, and adjustment”, in International Journal of Intercultural Relations, 2006, 30, pp. 478-506.Zilles, A. M. S. &King, K. “Self-presentation in sociolinguistic interviews: Identities and language variation in Panambi”, in Sociolinguistics, 2005, 9, pp. 74-75.中文参考书目【英】安德鲁·埃德加著,杨礼根与朱松峰译:《哈贝马斯:关键概念》,南京:江苏人民出版社,2009年版。

N ENG DA-EPOCH-R

N ENG DA-EPOCH-R

Dose-Adjusted EPOCH-Rituximab Therapy in Primary Mediastinal B-Cell LymphomaKieron Dunleavy, M.D., Stefania Pittaluga, M.D., Ph.D., Lauren S. Maeda, M.D., Ranjana Advani, M.D., Clara C. Chen, M.D., Julie Hessler, R.N., Seth M. Steinberg, Ph.D., Cliona Grant, M.D., George Wright, Ph.D., Gaurav Varma,M.S.P.H., Louis M. Staudt, M.D., Ph.D., Elaine S. Jaffe, M.D., and Wyndham H. Wilson, M.D., Ph.D.N Engl J Med 2013; 368:1408-1416April 11, 2013DOI: 10.1056/NEJMoa1214561Share:AbstractArticleReferencesCiting Articles (26)LettersKaplan–Meier Estimates of Event-free and Overall Survival of Patients with Primary Mediastinal B-CellLymphoma Receiving DA-EPOCH-R, According to Study Group.Cardiac Ejection Fraction after Treatment with DA-EPOCH-R in 42 Patients in the Prospective NCI Cohort.Primary mediastinal B-cell lymphoma is adistinct pathogenetic subtype of diffuse large-B-cell lymphoma that arises in the thymus.1,2Although it comprises only 10% of cases of diffuse large-B-cell lymphoma, primary mediastinal B-cell lymphoma, which predominantly affects young women,3 is aggressive and typically ismanifested by a localized, bulky mediastinal mass, often with pleural and pericardial effusions.Less commonly, the disease involves extranodal sites, including the lung, kidneys, gastrointestinal organs, or brain.4,5 This disease is clinically and biologically related to nodular sclerosingHodgkin's lymphoma; the putative cell of origin for both conditions is a thymic B cell.1,2The molecular features of primary mediastinal B-cell lymphoma, and its relationship to Hodgkin'slymphoma and other types of diffuse large-B-cell lymphoma, have been studied.1,2,6-8 Mostpatients with primary mediastinal B-cell lymphoma have mutations in the B-cell lymphoma 6 gene (BCL6), usually along with somatic mutations in the immunoglobulin heavy-chain gene, suggesting late-stage germinal-center differentiation.6,7 Unlike other types of diffuse large-B-cell lymphoma,primary mediastinal B-cell lymphoma involves defective immunoglobulin production despite theexpression of the B-cell transcription factors OCT-2, BOB.1, and PU.1. More than half of patients with the disease also have amplification of the REL proto-oncogene and the JAK2 tyrosine kinase gene, which frequently are found in patients with Hodgkin's lymphoma, suggesting that thesediseases are related.9,10 Furthermore, genes that are more highly expressed in primarymediastinal B-cell lymphoma than in other types of diffuse large-B-cell lymphoma arecharacteristically overexpressed in Hodgkin's lymphoma.2Prospective studies in primary mediastinal B-cell lymphoma are few, which has led to conflictingfindings and a lack of treatment standards.11-14 Nonetheless, several observations have emerged from the literature. First, in most patients, adequate tumor control is not achieved with standardimmunochemotherapy, necessitating routine mediastinal radiotherapy.13-15 Second, even withradiotherapy, which is associated with serious late side effects, 20% of patients have diseaseprogression.11,13 Third, more aggressive chemotherapy is associated with an improvedoutcome.12,13 Consistent with this observation, we found that the dose-intense chemotherapy regimen consisting of dose-adjusted etoposide, doxorubicin, and cyclophosphamide with vincristine and prednisone (DA-EPOCH) had a favorable overall survival rate (79%) without consolidation radiotherapy in patients with primary mediastinal B-cell lymphoma.16 On the basis of the hypothesis that rituximab may improve treatment, we undertook a phase 2, prospective study of DA-EPOCH plus rituximab (DA-EPOCH-R) to determine whether it would improve outcomes and obviate the need for radiotherapy.METHODSStudy ConductThe study was designed and the manuscript was written by the last author. All authors reviewed and approved the draft of the manuscript submitted for publication. All the authors vouch for the adherence of the study to the protocol (available with the full text of this article at ) and for the completeness and accuracy of the data and analysis. The prospective study was approved by the institutional review board of the National Cancer Institute (NCI). All patients provided written informed consent. The retrospective analysis was approved by the institutional review board at Stanford University.Filgrastim was provided to the NCI through an agreement with Amgen, which played no role in the study design, analysis, or data collection. No other commercial support was provided for the prospective study.Prospective NCI StudyPatientsFrom November 1999 through August 2012, we prospectively enrolled 51 patients with untreated primary mediastinal B-cell lymphoma in an uncontrolled phase 2 study of DA-EPOCH-R. The primary study objectives were the rate of complete response, the rate of progression-free survival, and the toxicity of DA-EPOCH-R.All eligible patients had not received any previous systemic chemotherapy, had adequate organ function, and had negative results on testing for the human immunodeficiency virus; among women with childbearing potential, a negative test for pregnancy was required. Any localized mediastinal masses (stage I) had to measure at least 5 cm in the greatest dimension. Evaluations included standard blood tests, whole-body computed tomography (CT), and bone marrow biopsy. Assessment of cardiac function, by means of echocardiography, and of central nervous system disease, with the use of CT or magnetic resonance imaging (MRI) and flow cytometry or cytologic analysis of cerebral spinal fluid, were performed if clinically indicated.Study TherapyPatients received chemotherapy consisting of DA-EPOCH-R with filgrastim for 6 to 8 cycles.17,18 Disease sites were evaluated after cycles 4 and 6. Patients with a reduction of more than 20% inthe greatest diameter of their tumor masses between cycles 4 and 6 received 8 cycles of treatment. Patients with a reduction of 20% or less between cycles 4 and 6 discontinued therapy after 6 cycles. The method of administering the DA-EPOCH-R is summarized in the Supplementary Appendix (available at ).We used standard criteria for tumor response to assess the study end points.19,20 We used 18F-fluorodeoxyglucose–positron-emission tomography–CT (FDG-PET-CT) after therapy to evaluate residual masses. Patients who had a maximum standardized uptake value greater than that of the mediastinal blood pool in the residual mediastinal mass underwent repeat scans at approximately 6-week intervals until normalization or stabilization. Mediastinal blood pool activity was defined as the maximum standardized uptake value over the great vessels and ranged from 1.5 to 2.5 in the study population. Tumor biopsy was performed as clinically indicated. Patients with evidence of thymic rebound underwent repeat CT at 6-week intervals until stabilization. All FDG-PET-CT scans were reviewed and scored by the same nuclear-medicine physician. No patients received radiation treatment during this prospective study.Independent, Retrospective Stanford StudyTo provide an independent assessment of DA-EPOCH-R, we collaborated with investigators at Stanford University Medical Center who had begun to use DA-EPOCH-R in 2007 to treat primary mediastinal B-cell lymphoma.21 They reviewed all charts from 2007 through 2012 and found 16 previously untreated patients who had been consecutively treated with DA-EPOCH-R; none required radiotherapy. NCI investigators confirmed the presence of primary mediastinal B-cell lymphoma in all 16 patients, according to the WHO [World Health Organization] Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition.3 Standard immunohistochemical studies were performed as indicated.3,18Other Comparative DataTo provide a long-term assessment of the DA-EPOCH platform, we reviewed the pathological data for all patients from our phase 2 study of DA-EPOCH in patients with diffuse large-B-cell lymphoma, which also did not permit radiotherapy, and identified 18 patients with primary mediastinal B-cell lymphoma.16Statistical AnalysisWe calculated the duration of overall survival from the date of enrollment until the time of death or last follow-up. The duration of event-free survival was calculated from the date of enrollment until the date of progression, radiotherapy, discovery of a second mass, or time of last follow-up. We used the Kaplan–Meier method to determine the probability of overall or event-free survival.22 Patients' characteristics were compared by means of Fisher's exact test for dichotomous variables and by means of the Wilcoxon rank-sum test for continuous variables. All P values are two-tailed.The median follow-up was calculated from the date of enrollment through November 2012, the date of the most recent update.RESULTSBaseline Characteristics and Clinical OutcomesThe 51 patients enrolled in the NCI phase 2 prospective study had a median age of 30 years (range, 19 to 52) and a median tumor diameter of 11 cm; 59% were women (Table 1TABLE 1Baseline Characteristics of the Study Patients.). Indicators of advanced disease included bulky tumor with a greatest diameter of 10 cm or more (in 65% of patients), an elevated lactate dehydrogenase level (in 78%), and stage IV disease (in 29%).The 16 patients identified in the retrospective Stanford study had baseline characteristics similar to those of our 51 patients (Table 1) except for a significantly lower frequency of extranodal disease and significantly older age; 56% of patients had bulky disease, and 44% of patients had stage IV disease.At a median follow-up of 63 months (range, 3 to 156), the event-free survival rate in the prospective NCI study was 93% (95% confidence interval [CI], 81 to 98), and the overall survivalrate was 97% (95% CI, 81 to 99) (Figure 1A and 1B FIGURE 1Kaplan–Meier Estimates of Event-free and Overall Survival of Patients with Primary Mediastinal B-Cell Lymphoma Receiving DA-EPOCH-R, According to Study Group.). Three patients had evidence of disease after DA-EPOCH-R treatment; two had persistent focal disease, as detected on FDG-PET-CT, and one had disease progression. Two of these patients underwent mediastinal radiotherapy, and one was observed after excisional biopsy. All three patients became disease-free. One later died from acute myeloid leukemia, while still in remission from his primary mediastinal B-cell lymphoma.In the retrospective Stanford cohort, over a median follow-up of 37 months (range, 5 to 53), 100% of patients (95% CI, 79 to 100) were alive and event-free (Figure 1C and 1D).Finally, we assessed the outcome for 18 patients with primary mediastinal B-cell lymphoma who were enrolled in our phase 2 study of DA-EPOCH.16 These patients had baseline characteristics similar to those in the prospective DA-EPOCH-R study (data not shown). Over a median follow-up of 16 years, the event-free and overall survival rates were 67% (95% CI, 44 to 84) and 78% (95% CI, 55 to 91), respectively. No cardiac failure or second tumors were observed.The event-free and overall survival rates were greater with the addition of rituximab in the NCI prospective cohort than in the cohort of 18 patients who received DA-EPOCH alone (P=0.007 andP=0.01, respectively). This finding suggests that the addition of rituximab may account for the improvement and is consistent with other reports.11FDG-PET-CT FindingsTo identify DA-EPOCH-R treatment failures early, the 36 patients who were found to have residual mediastinal masses in the prospective study underwent FDG-PET-CT in order to optimize curative radiotherapy. Half the patients had a maximum standardized uptake value that was no more than the value in the mediastinal blood pool, which represents the upper limit of the normal range ofuptake (Table 2TABLE 2FDG-PET-CT Findings after DA-EPOCH-R Therapy in the Prospective NCI Cohort.). The other half had a maximum standardized uptake value that was more than the value in the mediastinal blood pool. Although diffuse or focal uptake within the residual tumor mass that is higher than that in the mediastinal blood pool has been considered indicative of lymphoma,20 among these 18 patients, only 3 (with maximum standardized uptake values of 5.9, 10.2, and 14.5) were found to have residual lymphoma. Thus, FDG-PET-CT had a positive predictive value of 17% and a negative predictive value of 100%.Among the 15 patients with a maximum standardized uptake value greater than that in the mediastinal blood pool who did not have disease, 10 underwent repeat FDG-PET-CT; the other 5 did not undergo additional screening, because their initial FDG-PET-CT scans were interpreted as unlikely to represent disease. The 10 patients underwent 1 to 6 additional FDG-PET-CT scans (total, 26); all the findings were interpreted as false positive results on the basis of stabilization or improvement of the maximum standardized uptake value. None of the 10 patients had a recurrence of lymphoma during follow-up.Three patients underwent post-treatment biopsy. One, with a maximum standardized uptake value of 5.9, had a viable tumor of less than 1 cm in area. Owing to the uncertain importance of this finding, the patient was followed for 7 years without treatment, and the tumor did not recur during follow-up. Two patients, with maximum standardized uptake values of 4.6 and 6.4, had negative biopsy results and no tumor recurrence during 6 years of follow-up.In two patients, treatment failed but repeat biopsy was not performed. One patient had disease progression on CT during treatment, and the other had a post-treatment maximum standardized uptake value that increased from 10.2 to 19, consistent with disease progression.Dose and Toxicity of DA-EPOCH-R in the NCI StudyIn the NCI study, 90% of patients received six cycles, and 10% received eight cycles, of DA-EPOCH-R. More than half the 51 patients had an escalation to at least dose level 4, representing a 73% increase over dose level 1; 6% of patients did not have a dose escalation. More than half thepatients received 69 mg of doxorubicin per square meter of body-surface area for at least one cycle and cumulative doses of 345 to 507 mg per square meter. To assess cardiac toxic effects, ejection fractions were measured in 42 patients. All had normal ejection fractions up to 10 yearsafter treatment (Figure 2FIGURE 2Cardiac Ejection Fraction after Treatment with DA-EPOCH-R in 42 Patients in the Prospective NCI Cohort.). There was no significant relationship between the ejection fraction and the length of time since treatment (P=0.30) or between the ejection fraction and the cumulative doxorubicin dose (P=0.20), and no significant interaction between the dose and time interval (P=0.40).Toxicity was assessed during the administration of all 294 cycles of DA-EPOCH-R. The targeted absolute neutrophil count of less than 500 cells per cubic milliliter occurred during 50% of cycles. Thrombocytopenia (<25,000 platelets per cubic millimeter) occurred during 6% of cycles, and hospitalization for fever and neutropenia occurred during 13% of cycles. Nonhematopoietic toxic effects were similar to those that have been reported previously.17,18 One patient died from acute myeloid leukemia while in remission from his primary mediastinal B-cell lymphoma, 49 months after treatment. Owing to the unexpected severe neutropenia during treatment in this patient, we looked for a germline telomerase mutation, which is associated with chemotherapy intolerance and myeloid leukemia.23 Telomere shortening (length, 2.5 SD below the mean) and a heterozygous mutation for the telomerase reverse transcriptase gene (TERT) codon Ala1062Thr were identified.DISCUSSIONThe use of DA-EPOCH-R obviated the need for radiotherapy in all but 2 of 51 patients (4%) with primary mediastinal B-cell lymphoma in a prospective cohort, and no patients had recurring disease over a median follow-up of more than 5 years (maximum, >13). Furthermore, in an independent retrospective cohort, treatment with DA-EPOCH-R in patients with primary mediastinal B-cell lymphoma resulted in an event-free survival rate of 100%. Despite the limitations of the phase 2 study and the retrospective study, these findings suggest that DA-EPOCH-R is a therapeutic advance for this type of lymphoma. Our results suggest that rituximab significantly improves the outcome of chemotherapy in patients with primary mediastinal B-cell lymphoma.The toxicity of DA-EPOCH-R was similar to that reported previously.16 The use of neutrophil-based dose adjustment maximized the delivered dose and limited the incidence of fever and neutropenia to 13% of the cycles. The infusional schedule of doxorubicin allowed for the delivery of high maximal and cumulative doses of doxorubicin without clinically significant cardiac toxic effects.24,25We used post-treatment FDG-PET-CT to identify patients who had persistent disease and a possible need for radiotherapy. Unlike the high clinical accuracy of FDG-PET-CT in other aggressive lymphomas,20 we found the technique to have a poor positive predictive value in primary mediastinal B-cell lymphoma. We frequently observed residual mediastinal masses that continued to shrink for 6 months, suggesting that inflammatory cells might account for the FDG uptake. These findings indicate that FDG-PET-CT uptake alone is not accurate for determining the presence of disease in these patients.There is no established standard treatment for primary mediastinal B-cell lymphoma. Although R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) has become a de facto standard, it is not universally accepted.11,12 Most strategies also incorporate consolidation radiotherapy to overcome the inadequacy of immunochemotherapy, although some observers have questioned its routine use.12,26 The most accurate assessment of R-CHOP and radiotherapy is a subgroup analysis of patients with primary mediastinal B-cell lymphoma in the Mabthera International Trial Group study of R-CHOP–based treatment.11 Among 44 patients, 73% received radiotherapy, with an event-free survival rate of 78% at 34 months.11 These results indicate that patients who receive R-CHOP–based treatment, most of whom are young women, may have serious long-term consequences of radiotherapy, including second tumors and the acceleration of atherosclerosis and anthracycline-mediated cardiac damage.27Current standard therapy is also inadequate for children with primary mediastinal B-cell lymphoma. In a recent subgroup analysis in the FAB/LMB96 international study, the event-free and overall survival rates were 66% and 73%, respectively, among children receiving a multiagent pediatric regimen.28Retrospective studies have long suggested that patients with primary mediastinal B-cell lymphoma have improved outcomes with the receipt of regimens of increased dose intensity.13 Dose intensity appears to be important in treating Hodgkin's lymphoma, a closely related disease.29 Indeed, outcomes associated with the use of DA-EPOCH-R may well be related to dose intensity as well as the continuous infusion schedule.30 DA-EPOCH therapy involves the administration of pharmacodynamic doses to normalize drug exposure among patients and maximizes the rate of administration. DA-EPOCH may also more effectively modulate the expression of BCL6,7 which encodes a key germinal-center B-cell transcription factor that suppresses genes involved in lymphocyte activation, differentiation, cell-cycle arrest (p21 and p27Kip1), and response to DNA damage (p53 and ATR) and that is expressed by most primary mediastinal B-cell lymphomas (Table 1).31 The inhibition of topoisomerase II also leads to down-regulation of BCL6 expression, suggesting that regimens directed against topoisomerase II may have increased efficacy in treating primary mediastinal B-cell lymphoma. In this regard, DA-EPOCH-R was designed to inhibit topoisomerase II by including two topoisomerase II inhibitors, etoposide and doxorubicin, and maximizing topoisomerase II inhibition by way of extended drug exposure.16In conclusion, our results indicate that DA-EPOCH-R had a high cure rate and obviated the need for radiotherapy in patients with primary mediastinal B-cell lymphoma. To provide confirmatory evidence, an international trial of DA-EPOCH-R in children with primary mediastinal B-cell lymphoma has been initiated ( number, NCT01516567).。

最新定量聚合酶链反应QPCR测定技术PPT课件

最新定量聚合酶链反应QPCR测定技术PPT课件
因此,如果建立一个使用外标准的PCR定量方法, 则必须进行方法的精密度(批内变异)和重复性 (批间变异)分析,以确定其应用的局限性。
TaqMan实时荧光定量PCR
分子信标实时荧光定量PCR
动力学定量PCR方法
第一步:确定PCR扩增的效率; 第二步:根据相应的公式计算原始
模板数。
扩增效率的计算(1)
定量测定结果报告:根据所使用的测定方 法的测定范围报告结果,如样本测定结果 高出此范围,则可报告>多少,也可对样本 稀释后再检测;如低于此范围,则报告<多 少,如<103拷贝数/ml,而不能报告为0拷贝 数/ml或阴性。
总结
1.定量测定重在定量,即如何改善扩增指数期的线 性及其范围。
2.定量测定的准确性较之测定下限要重要得多。 3.非竞争性内标和竞争性内标对于使用内标的定量
高浓度/高效率 高浓度/低效率 低浓度/高效率
N : 扩增分子的数 目
n : 扩增循环的次 数
n
定量PCR与定性PCR测定的最根本的区别
定量PCR测定的测定点为PCR扩增的指 数扩增期;而定性PCR测定的测定点则多为 PCR扩增的平台期。
定量PCR的方法
定量PCR方法可归为三大类,即外标方法、 动力学方法和内标共扩增方法
PCR及有关技术的发展历史(3)
1987 当年7月Cetus 公司在美国获得PCR基本技术
专利批准。 成立于1985年底的Perkin-Elmer Cetus仪器公
司 ( PECI ) 于这一年的11月推出了第一 个PCR 试剂产品及第一台热循环仪。
1989 Science 报道了耐热性DNA多聚酶 Taq 酶的 发现,预示着分子时代的到来。12月《Science》杂 志将PCR和它所使用的聚合酶命名为第一个“年 度分子”。 Hoffmann-La Roche 公司和Cetus 开 始合作将 PCR应用于临床诊断 。

早些年份考研英语大纲范文

早些年份考研英语大纲范文

早些年份考研英语大纲范文In the ever-evolving landscape of education, the challenges and opportunities associated with higher education have undergone significant transformations. This essay delves into the changing paradigms of education, focusing on the evolving role of the postgraduate entrance examination, particularly its English component, in the context of societal and technological advancements.The early years of the postgraduate entrance examination marked a period where the focus was primarily on assessing basic language proficiency and comprehension skills. The exam questions were often straightforward, testing the candidates' knowledge of grammar, vocabulary, and reading comprehension. However, as society and technology have advanced, the nature of the examination has undergone a radical shift.Today, the exam not only tests the candidates'linguistic proficiency but also their ability to apply English in real-world contexts. The emphasis is on analytical thinking, critical evaluation, and the ability to communicate ideas effectively. This shift reflects thechanging demands of the job market and the increasing globalization of higher education.Moreover, the integration of technology in education has further transformed the exam experience. Online resources and digital tools have become integral to the preparation process, enabling candidates to access a wealth of information and practice materials. However, this also poses new challenges, as candidates are required to navigate the vast amount of information available and develop effective study strategies.Amidst these changes, it is crucial for educators and policymakers to recognize the need for continuous innovation in education systems. The postgraduate entrance examination must adapt to reflect the evolving demands of society and the job market while maintaining its focus on评估基础语言能力和理解能力。

TPO20阅读解析-Passage2

TPO20阅读解析-Passage2

Q1正确答案:C解析:momentous“重要的,重大的”,所以very important正确。

从单词本身看,意思上应该跟moment相关,“时刻的”,A和D明显不合文意。

原句提到这些变化对于本地稀疏的人口有什么影响,“常规的”影响明显不正确,答案是C。

Q2正确答案:B解析:EXCEPT题,排除法。

A/C/D都在第一段第一句中提到了,只有B没有提到,所以答案是B。

Q3正确答案:D解析:指代题,需要沿着提到的内容往前看,前一句提到由于农业和城镇的发展,人口成千上万,紧接着提到this change,说这个变化指的就是人口的增长,所以答案是D。

Q4正确答案:B解析:exploit“开采,开发,利用”,所以B的utilize正确。

原句提到当地人怎么样自然景观,之后举了很多例子,有放牧有打猎等等,都是在利用自然环境,所以是“利用”。

C“定居”和D“改善”都不正确;A选项不选,后面的例子说明不只是探索,所以答案是B。

Q5正确答案:A解析:根据这些例子找定位,提到定居点里包含很多通过贸易获得的外来物品,诸如……,所以列举的这些东西都是外来品,A是正确答案。

BCD都未提及。

Q6正确答案:D解析:cramped“局促的,狭窄的,难懂的”,所以confined正确。

原句提到在公元前9500年,一个村子的人都在一个什么样的住处里,根据句义,这里强调的是比较小,所以其他的都不合文意。

而且extend刚好和confine是相反的意思,所以D是答案。

Q7正确答案:D解析:Abu Hureyra做关键词定位至第一句的后半句和第二句的前半句,一直在说AH,接着往下看,提到接下来的1500年里,他们所在的地方气候温暖,种子丰富,所以答案是D,C与原文相反;A和B选项的内容在此并未提及。

Q8正确答案:C解析:shift“转变,转换,倒班”,所以最接近的答案是change。

原句提到漂浮的样品使得植物学家研究植物集群习惯的什么就好像在显微镜下看风景一样,风景是会变的,所以答案是change。

past软件详细教程

Palaeontologia ElectronicaPAST: PALEONTOLOGICAL STATISTICS SOFTWARE PACKAGE FOREDUCATION AND DATA ANALYSISØyvind Hammer, David A.T. Harper, and Paul D. RyanØyvind Hammer. Paleontological Museum, University of Oslo, Sars gate1, 0562 Oslo, NorwayDavid A. T. Harper. Geological Museum, Øster Voldgade 5-7, University of Copenhagen, DK-1350 Copen-hagen K, DenmarkPaul D. Ryan. Department of Geology, National University of Ireland, Galway, IrelandABSTRACTA comprehensive, but simple-to-use software package for executing a range ofstandard numerical analysis and operations used in quantitative paleontology hasbeen developed. The program, called PAST (PAleontological STatistics), runs on stan-dard Windows computers and is available free of charge. PAST integrates spread-sheet-type data entry with univariate and multivariate statistics, curve fitting, time-series analysis, data plotting, and simple phylogenetic analysis. Many of the functionsare specific to paleontology and ecology, and these functions are not found in stan-dard, more extensive, statistical packages. PAST also includes fourteen case studies(data files and exercises) illustrating use of the program for paleontological problems,making it a complete educational package for courses in quantitative methods.KEY WORDS: Software, data analysis, educationCopyright: Palaeontological Association, 22 June 2001Submission: 28 February 2001 Acceptance: 13 May 2001INTRODUCTIONEven a cursory glance at the recent paleontological literature should convince anyone that quantitative methods in pale-ontology have arrived at last. Neverthe-less, many paleontologists still hesitate in applying such methods to their own data. One of the reasons for this has been the difficulty in acquiring and using appropri-ate data-analysis software. The ‘PALSTAT’program was developed in the 1980s in order to minimize such obstacles and pro-vide students with a coherent, easy-to-use package that supported a wide range of algorithms while allowing hands-on experi-ence with quantitative methods. The first PALSTAT version was programmed for the BBC microcomputer (Harper and Ryan 1987), while later revisions were made for the PC (Ryan et al. 1995). Incorporating univariate and multivariate statistics and other plotting and analytical functions spe-cific to paleontology and ecology, PAL-STAT gained a wide user base among both paleontologists and biologists.After some years of service, however, it was becoming clear that PALSTAT had to undergo major revision. The DOS-based user interface and an architecture designed for computers with miniscule memories (by modern standards) was becoming an obstacle for most users. Also, the field of quantitative paleontology has changed and expanded considerably in the last 15 years, requiring the imple-mentation of many new algorithms. There-fore, in 1999 we decided to redesign the program totally, keeping the general con-cept but without concern for the original source code. The new program, called PAST (PAleontological STatistics) takes full advantage of the Windows operating system, with a modern, spreadsheet-based, user interface and extensive graphics. Most PAST algorithms produce graphical output automatically, and the high-quality figures can be printed or pasted into other programs. The function-ality has been extended substantially with inclusion of important algorithms in the standard PAST toolbox. Functions found in PAST that were not available in PAL-STAT include (but are not limited to) parsi-mony analysis with cladogram plotting, detrended correspondence analysis, prin-cipal coordinates analysis, time-series analysis (spectral and autocorrelation), geometrical analysis (point distribution and Fourier shape analysis), rarefaction, modelling by nonlinear functions (e.g., logistic curve, sum-of-sines) and quantita-tive biostratigraphy using the unitary asso-ciations method. We believe that the functions we have implemented reflect the present practice of paleontological data analysis, with the exception of some func-tionality that we hope to include in future versions (e.g., morphometric analysis with landmark data and more methods for the validation and correction of diversity curves).One of the main ideas behind PAST is to include many functions in a single pro-gram package while providing for a con-sistent user interface. This minimizes time spent on searching for, buying, and learn-ing a new program each time a new method is approached. Similar projects are being undertaken in other fields (e,g., systematics and morphometry). One example is Wayne Maddison’s ‘Mesquite’package (/mesquite/mesquite.html).An important aspect of PALSTAT was the inclusion of case studies, including data sets designed to illustrate possible uses of the algorithms. Working through these examples allowed the student to obtain a practical overview of the different methodologies in a very efficient way. Some of these case studies have been adjusted and included in PAST, and new case studies have been added in order to demonstrate the new features. The case studies are primarily designed as student exercises for courses in paleontological data analysis. The PAST program, docu-mentation, and case studies are available free of charge at http://www.nhm.uio.no/ ~ohammer/past.PLOTTING AND BASIC STATISTICSGraphical plotting functions (see http:// www.nhm.uio.no/~ohammer/past/plot.html) in PAST include different types of graph, histogram, and scatter plots. The program can also produce ternary (trian-gle) plots and survivorship curves.Descriptive statistics (see http:// www.nhm.uio.no/~ohammer/past/ univar.html) include minimum, maximum, and mean values, population variance, sample variance, population and sample standard deviations, median, skewness, and kurtosis.For associations or paleocommunity data, several diversity statistics can be computed: number of taxa, number of indi-viduals, dominance, Simpson index, Shannon index (entropy), Menhinick’s and Margalef’s richness indices, equitability, and Fisher’s a (Harper 1999).Rarefaction (Krebs 1989) is a method for estimating the number of taxa in a small sample, when abundance data for a larger sample are given. With this method, the number of taxa in samples of different sizes can be compared. An example appli-cation of rarefaction in paleontology is given by Adrain et al. (2000).The program also includes standard statistical tests (see http:// www.nhm.uio.no/~ohammer/past/ twosets.html) for univariate data, includ-ing: tests for normality (chi-squared and Shapiro-Wilk), the F and t tests, one-way ANOVA,χ2 for comparing binned samples, Mann-Whitney’s U test and Kolmogorov-Smirnov association test (non-parametric), and both Spearman’s r and Kendall’s t non-parametric rank-order tests. Dice and Jaccard similarity indices are used for comparing associations limited to absence/presence data. The Raup-Crick randomization method for comparing associations (Raup and Crick 1979) is also implemented. Finally, the program can also compute correlation matrices and perform contingency-table analysis.MULTIVARIATE ANALYSISPaleontological data sets, whether based on fossil occurrences or morphol-ogy, often have high dimensionality. PAST includes several methods for multivariate data analysis (see http://www.nhm.uio.no/ ~ohammer/past/multivar.html), including methods that are specific to paleontology and biology.Principal components analysis (PCA) is a procedure for finding hypothetical vari-ables (components) that account for as much of the variance in a multidimensional data set as possible (Davis 1986, Harper 1999). These new variables are linear combinations of the original variables. PCA is a standard method for reducing the dimensionality of morphometric and eco-logical data. The PCA routine finds the eigenvalues and eigenvectors of the vari-ance-covariance matrix or the correlation matrix. The eigenvalues, giving a measure of the variance accounted for by the corre-sponding eigenvectors (components), are displayed together with the percentages of variance accounted for by each of these components. A scatter plot of these data projected onto the principal components is provided, along with the option of including the Minimal Spanning Tree, which is the shortest possible set of connected lines joining all points. This may be used as a visual aid in grouping close points (Harper 1999). The component loadings can also be plotted. Bruton and Owen (1988) describe a typical morphometrical applica-tion of PCA.Principal coordinates analysis (PCO) is another ordination method, somewhat similar to PCA. The PCO routine finds the eigenvalues and eigenvectors of a matrix containing the distances between all data points, measured with the Gower distance or the Euclidean distance. The PCO algo-rithm used in PAST was taken from Davis (1986), which also includes a more detailed description of the method and example analysis.Correspondence analysis (CA) is a further ordination method, somewhat simi-lar to PCA, but for counted or discrete data. Correspondence analysis can com-pare associations containing counts of taxa or counted taxa across associations. Also, CA is more suitable if it is expected that species have unimodal responses to the underlying parameters, that is they favor a certain range of the parameter andbecome rare under for lower and higher values (this is in contrast to PCA, that assumes a linear response). The CA algo-rithm employed in PAST is taken from Davis (1986), which also includes a more detailed description of the method and example analysis. Ordination of both sam-ples and taxa can be plotted in the same CA coordinate system, whose axes will normally be interpreted in terms of envi-ronmental parameters (e.g., water depth, type of substrate temperature).The Detrended Correspondence (DCA) module uses the same ‘reciprocal averaging’ algorithm as the program Dec-orana (Hill and Gauch 1980). It is special-ized for use on “ecological” data sets with abundance data (taxa in rows, localities in columns), and it has become a standard method for studying gradients in such data. Detrending is a type of normalization procedure in two steps. The first step involves an attempt to “straighten out”points lying along an arch-like pattern (= Kendall’s Horseshoe). The second step involves “spreading out” the points to avoid artificial clustering at the edges of the plot.Hierarchical clustering routines pro-duce a dendrogram showing how and where data points can be clustered (Davis 1986, Harper 1999). Clustering is one of the most commonly used methods of mul-tivariate data analysis in paleontology. Both R-mode clustering (groupings of taxa), and Q-mode clustering (grouping variables or associations) can be carried out within PAST by transposing the data matrix. Three different clustering algo-rithms are available: the unweighted pair-group average (UPGMA) algorithm, the single linkage (nearest neighbor) algo-rithm, and Ward’s method. The similarity-association matrix upon which the clusters are based can be computed using nine dif-ferent indices: Euclidean distance, correla-tion (using Pearson’s r or Spearman’s ρ,Bray-Curtis, chord and Morisita indices for abundance data, and Dice, Jaccard, and Raup-Crick indices for presence-absence data.Seriation of an absence-presence matrix can be performed using the algo-rithm described by Brower and Kyle (1988). For constrained seriation, columns should be ordered according to some external criterion (normally stratigraphic level) or positioned along a presumed fau-nal gradient. Seriation routines attempt to reorganize the data matrix such that the presences are concentrated along the diagonal. Also, in the constrained mode, the program runs a ‘Monte Carlo’ simula-tion to determine whether the original matrix is more informative than a random matrix. In the unconstrained mode both rows and columns are free to move: the method then amounts to a simple form of ordination.The degree of separation between to hypothesized groups (e.g., species or morphs) can be investigated using dis-criminant analysis (Davis 1986). Given two sets of multivariate data, an axis is con-structed that maximizes the differences between the sets. The two sets are then plotted along this axis using a histogram. The null hypothesis of group means equal-ity is tested using Hotelling’s T2 test. CURVE FITTING AND TIME-SERIES ANALYSISCurve fitting (see http:// www.nhm.uio.no/~ohammer/past/fit-ting.html) in PAST includes a range of lin-ear and non-linear functions.Linear regression can be performed with two different algorithms: standard (least-squares) regression and the ”Reduced Major Axis” method. Least-squares regression keeps the x values fixed, and it finds the line that minimizes the squared errors in the y values. Reduced Major Axis minimizes both the xand the y errors simultaneously. Both x and y values can also be log-transformed, in effect fitting the data to the “allometric”function y=10b x a.An allometric slope value around 1.0 indicates that an “isomet-ric” fit may be more applicable to the data than an allometric fit. Values for the regression slope and intercepts, their errors, aχ2correlation value, Pearson’s r coefficient, and the probability that the col-umns are not correlated are given.In addition, the sum of up to six sinu-soids (not necessarily harmonically related) with frequencies specified by the user, but with unknown amplitudes and phases, can be fitted to bivariate data. This method can be useful for modeling periodicities in time series, such as annual growth cycles or climatic cycles, usually in combination with spectral analysis (see below). The algorithm is based on a least-squares criterion and singular value decomposition (Press et al. 1992). Fre-quencies can also be estimated by trial and error, by adjusting the frequency so that amplitude is maximized.Further, PAST allows fitting of data to the logistic equation y=a/(1+be-cx), using Levenberg-Marquardt nonlinear optimiza-tion (Press et al. 1992). The logistic equa-tion can model growth with saturation, and it was used by Sepkoski (1984) to describe the proposed stabilization of marine diversity in the late Palaeozoic. Another option is fitting to the von Berta-lanffy growth equation y=a(1-be-cx). This equation is used for modeling growth of multi-celled animals (Brown and Rothery 1993).Searching for periodicities in time series (data sampled as a function of time) has been an important and controversial subject in paleontology in the last few decades, and we have therefore imple-mented two methods for such analysis in the program: spectral analysis and auto-correlation. Spectral (harmonic) analysis of time series can be performed using the Lomb periodogram algorithm, which is more appropriate than the standard Fast Fourier Transform for paleontological data (which are often unevenly sampled; Press et al. 1992). Evenly-spaced data are of course also accepted. In addition to the plotting of the periodogram, the highest peak in the spectrum is presented with its frequency and power value, together with a probability that the peak could occur from random data. The data set can be optionally detrended (linear component removed) prior to analysis. Applications include detection of Milankovitch cycles in isotopic data (Muller and MacDonald 2000) and searching for periodicities in diversity curves (Raup and Sepkoski 1984). Autocorrelation (Davis 1986) can be carried out on evenly sampled tempo-ral-stratigraphical data. A predominantly zero autocorrelation signifies random data—periodicities turn up as peaks.GEOMETRICAL ANALYSISPAST includes some functionality for geometrical analysis (see http:// www.nhm.uio.no/~ohammer/past/mor-pho.html), even if an extensive morpho-metrics module has not yet been implemented. We hope to implement more extensive functionality, such as landmark-based methods, in future versions of the program.The program can plot rose diagrams (polar histograms) of directions. These can be used for plotting current-oriented specimens, orientations of trackways, ori-entations of morphological features (e.g., trilobite terrace lines), etc. The mean angle together with Rayleigh’s spread are given. Rayleigh’s spread is further tested against a random distribution using Ray-leigh’s test for directional data (Davis 1986). A χ2 test is also available, givingthe probability that the directions are ran-domly and evenly distributed.Point distribution statistics using near-est neighbor analysis (modified from Davis 1986) are also provided. The area is esti-mated using the convex hull, which is the smallest convex polygon enclosing the points. The probability that the distribution is random (Poisson process, giving an exponential nearest neighbor distribution) is presented, together with the ‘R’ value. Clustered points give R<1, Poisson pat-terns give R~1, while over-dispersed points give R>1. Applications of this mod-ule include spatial ecology (are in-situ bra-chiopods clustered) and morphology (are trilobite tubercles over-dispersed; see Hammer 2000).The Fourier shape analysis module (Davis 1986) accepts x-y coordinates digi-tized around an outline. More than one shape can be analyzed simultaneously. Points do not need to be evenly spaced. The sine and cosine components are given for the first ten harmonics, and the coefficients can then be copied to the main spreadsheet for further analysis (e.g., by PCA). Elliptic Fourier shape analysis is also provided (Kuhl and Giardina 1982). For an application of elliptic Fourier shape analysis in paleontology, see Renaud et al. (1996).PHYLOGENETIC ANALYSIS (PARSIMONY)The cladistics package (see http:// www.nhm.uio.no/~ohammer/past/cla-dist.html) in PAST is fully operational, but is lacking comprehensive functionality. For example, there is no character reconstruc-tion (plotting of steps on the cladogram). The use of PAST in parsimony analysis should probably be limited to entry-level education and preliminary investigations. The parsimony algorithms used in PAST are from Kitching et al. (1998).Character states are coded using inte-gers in the range 0 to 255. The first taxon is treated as the outgroup and will be placed at the root of the tree. Missing val-ues are coded with a question mark. There are four algorithms available for finding short trees: branch-and-bound (finds all shortest trees), exhaustive (finds all short-est trees, and allows the plotting of tree-length distribution), heuristic nearest neighbor interchange (NNI) and heuristic subtree pruning and regrafting (SPR). Three different optimality criteria are avail-able: Wagner (reversible and ordered characters), Fitch (reversible and unor-dered characters), and Dollo (irreversible and ordered). Bootstrapping can be per-formed with a given number of replicates.All shortest (most parsimonious) trees can be viewed. If bootstrapping has been performed, a bootstrap value is given at the root of the subtree specifying each group.The consensus tree of all shortest (most parsimonious) trees can also be viewed. Two consensus rules are imple-mented: strict (groups must be supported by all trees) and majority (groups must be supported by more than 50% of the trees). PAST can read and export files in the NEXUS format, making it compatible with packages such as PAUP and MacClade.BIOSTRATIGRAPHICAL CORRELATION WITH UNITARY ASSOCIATIONSQuantitative or semi-quantitative methods for biostratigraphy are not yet in common use, except for the relatively sub-jective approach of graphical correlation. Such methods are, however, well devel-oped, and we hope that the inclusion of one method in PAST will help introduce more paleontologists to this field. We have chosen to implement Unitary Associations analysis (see http://www.nhm.uio.no/ ~ohammer/past/unitary.html) (Guex 1991)because of its solid theoretical basis and minimum of statistical assumptions.The data input consists of a presence-absence matrix with samples in rows and taxa in columns. Samples belong to a set of sections (localities), where the strati-graphical relationships within each section are known. The basic idea is to generate a set of assemblage zones (similar to ‘Oppel zones’) that are optimal in the sense that they give maximal stratigraphic resolution with a minimum of superpositional contra-dictions. An example of such a contradic-tion would be a section containing species A above species B, while assemblage 1 (containing species A) is placed below assemblage 2 (containing species B). The method of Unitary Associations is a logical but somewhat complicated procedure, consisting of several steps. Its implemen-tation in PAST does not include all the fea-tures found in the standard program, called BioGraph (Savary and Guex 1999), and advanced users are referred to that package.PAST produces a detailed report of the analysis, including maximal cliques, unitary associations, correlation table, reproducibility matrix, contradictions between cliques, biostratigraphic graph, graph of superpositional relationships between maximal cliques, and strong components (cycles) in the graphs (Guex 1991). It is important to inspect these results thoroughly in order to assess the quality of the correlation and to improve the quality of the data, if necessary. Angio-lini and Bucher (1999) give an example of such careful use of the method of Unitary Associations.CASE STUDIESThe fourteen case studies have been designed to demonstrate both the use of different data analysis methods in paleon-tology and the specific use of the functions in the program. The cases are taken from such diverse fields as morphology, taxon-omy, paleoecology, paleoclimatology, sedi-mentology, extinction studies, and biostratigraphy. The examples are taken from both vertebrate and invertebrate paleontology, and they cover the whole of the Phanerozoic. These case studies are well suited for an introductory course in paleontological data analysis and have been tested in classroom situations. The cases are organized into four main subject areas: morphology and taxonomy, bioge-ography and paleoecology, time-series analysis, and biostratigraphy.Case studies 1-51 involve the descrip-tion and analysis of morphological varia-tion of different sorts, while case study 6 targets some phylogenetic problems in a group of Cambrian trilobites and the mam-mals.Case Study 1 investigates the external morphology of the Permian brachiopod Dielasma, developing ontogenic models for the genus and comparing the growth rates and outlines of different samples from in and around a Permian reef com-plex. In a more focused exercise, Case Study 2 uses spatial statistics to assess the mode of distribution of tubercles on the cranidium of the trilobite Paradoxides from the middle Cambrian.Case Study 3 tackles the multivariate morphometrics of the Ordovician illaenid trilobite Stenopareia using Principal Com-ponents Analysis (PCA), Principal Coordi-nate Analysis (PCO), cluster and discriminant analyses to determine the validity of two species from Scandinavia.1.PE Note: The Case Study files are avail-able from the PE site, and also directly from the author. The links below point to the author's site, which will, as time and the author proceed, contain updates and newer versions. The author’s site is: http:// www.nhm.uio.no/~ohammer/past/.Case Study 4 demonstrates the use of Elliptic Fourier shape analysis and princi-pal components for detecting changes in trilobite cephalon shape through ontogeny.In Case Study 5, aspects of the allom-etric growth of the Triassic rhynchosaur Scaphonyx are investigated using regres-sion analysis.Case Study 6 investigates the phylo-genetic structure of the middle Cambrian Paradoxididae through cladistic analysis, using parsimony analysis and bootstrap-ping. Similar techniques can be applied to a matrix of 20 taxa of mammal; cla-dograms generated by the program can be compared with a cluster analysis of the data matrix.Case studies 7-11 cover aspects of paleobiogeography and paleoecology. Case Study 7 analyzes a global dataset of late Ordovician brachiopod distributions. A series of provincial faunas were developed against a background of regression and cooler surface waters during the first strike of the late Ordovician (Hirnantian) glacia-tion. Through the calculation of similarity and distance coefficients together with cluster analysis, these data can be orga-nized into a set of latitudinally controlled provinces. Seriation helps to develop any faunal, possibly climatically generated, gradients within the data structure.In Case Study 8 faunal changes through a well-documented section in the upper Llanvirn rocks of central Wales are investigated graphically and by the calcu-lation of diversity, dominance, and related parameters for each of ten horizons in the sections. The changes in faunas finger-print environmental shifts through the sec-tion, shadowed by marked changes in lithofacies. This dataset is ripe for consid-erable experimentation.Case Study 9 involves a re-evaluation of Ziegler’s classic Lower Paleozoic depth-related communities from the Anglo-Welsh area. Using a range of multi-variate techniques (similarity and distance coefficients, cluster analysis, detrended correspondence analysis, and seriation) the reality and mutual relationships of these benthic associations can be tested using a modified dataset.Case Study 10 discusses some well-known Jurassic shelly faunas from England and France. The integrity and onshore – offshore distribution of six Cor-allian bivalve-dominated communities is investigated with diversity measures, clus-ter analysis and detrended correspon-dence analysis.Case Study 11 completes the analysis of biotic assemblages with an investigation of the direction and orientation of a bed-ding-plane sample of brachiopod shells from the upper Ordovician rocks of Scot-land.Two cases involve the study of time series data. Case Study 12 investigates the periodicity of mass extinctions during the Permian to Recent time interval using spectral analysis. A number of diversity curves can be modeled for the Paleozoic and post-Paleozoic datasets available in Fossil Record 2, and turnover rates can be viewed for Phanerozoic biotas.Case Study 13 addresses the period-icity of oxygen isotope data from ice cores representing the last million years of Earth history.The final case study demonstrates the use of quantitative biostratigraphical corre-lation with the method of Unitary Associa-tions. Eleven sections from the Eocene of Slovenia are correlated using alveolinid foraminiferans studied by Drobne.CONCLUSIONStatistical and other quantitative meth-ods are now very much part of the paleon-tologists’ tool kit. PAST is a free, user-friendly and comprehensive package of statistical and graphical algorithms, tailormade for the scientific investigation of paleontological material. PAST provides a window on current and future develop-ments in this rapidly evolving research area. Together with a simple manual and linked case histories and datasets, the package is an ideal educational aid and first-approximation research tool. Planned future developments include extended functionality for morphometrics and the extension of available algorithms within the cladistics and unitary associations modules.REFERENCESAdrain, J.M., Westrop, S.R. and Chatterton, D.E. 2000.Silurian trilobite alphadiversity and the end-Ordovician mass extinction. Paleo-biology, 26:625-646.Angiolini, L. and Bucher, H. 1999. Taxonomy and quanti-tative biochronology ofGuadalupian brachiopods from the Khuff Formation, Southeastern Oman.Geobios, 32:665-699.Brower, J.C. and Kyle, K.M. 1988. Seriation of an original data matrix as applied topalaeoecology. Lethaia, 21:79-93.Brown, D. and Rothery, P. 1993. Models in biology: mathematics, statistics and computing. John Wiley & Sons, New York.Bruton, D.L. and Owen, A.W. 1988. The Norwegian Upper Ordovician illaenid trilobites. Norsk Geolo-gisk Tidsskrift, 68:241-258.Davis, J.C. 1986. Statistics and Data Analysis in Geol-ogy. John Wiley & Sons, New York.Guex, J. 1991. Biochronological Correlations. Springer Verlag, Berlin.Hammer, Ø. 2000. Spatial organisation of tubercles and terrace lines in Paradoxides forchhammeri - evi-dence of lateral inhibition. Acta Palaeontologica Polonica, 45:251-270.Harper, D.A.T. (ed.). 1999. Numerical Palaeobiology.John Wiley & Sons, New York.Harper, D.A.T. and Ryan, P.D. 1987. PALSTAT. A statisti-cal package for palaeontologists. Lochee Publica-tions and the Palaeontological Association.Hill, M.O. and Gauch Jr, H.G. 1980. Detrended Corre-spondence analysis: an improved ordination tech-nique. Vegetation, 42:47-58.Kitching, I.J., Forey, P.L., Humphries, C.J. and Williams,D.M. 1998. Cladistics. Oxford University Press,Oxford.Krebs, C.J. 1989. Ecological Methodology. Harper & Row, New York.Kuhl, F.P. and Giardina, C.R. 1982. Elliptic Fourier analy-sis of a closed contour. Computer Graphics and Image Processing, 18:259-278.Muller, R.A. and MacDonald, G.J. 2000. Ice ages and astronomical causes: Data, Spectral Analysis, and Mechanisms. Springer Praxis, Berlin.Press, W.H., Teukolsky, S.A., Vetterling, W.T. and Flan-nery, B.P. 1992. Numerical Recipes in C. Cambridge University Press, Cambridge.Raup, D. and Crick, R.E. 1979. Measurement of faunal similarity in paleontology. Journal of Paleontology, 53:1213-1227.Raup, D. and Sepkoski, J.J. 1984. Periodicities of extinc-tions in the geologic past. Proceedings of the National Academy of Science, 81:801-805. Renaud, S., Michaux, J., Jaeger, J.-J. and Auffray, J.-C.1996. Fourier analysis applied to Stephanomys (Rodentia, Muridae) molars: nonprogressive evolu-tionary pattern in a gradual lineage. Paleobiology, 22:255-265.Ryan, P.D., Harper, D.A.T. and Whalley, J.S. 1995. PAL-STAT, Statistics for palaeontologists. Chapman & Hall (now Kluwer Academic Publishers).Sepkoski, J.J. 1984. A kinetic model of Phanerozoic tax-onomic diversity. Paleobiology, 10:246-267. Savary, J. and Guex, J. 1999. Discrete Biochronological Scales and Unitary Associations: Description of the BioGraph Computer Program. Mémoires de Geolo-gie (Lausanne), 34.。

学习outcome英文翻译

SummaryIn this study, the main objectives for constructing logisticand Cox regression models were accomplished. For logisticregression analysis, the explanatory variables contributingto the probability of a student passing the USMLE Step 1were identified. It was evident that the MCA T (physicaland biological sciences) scores, number of sophomorecourses failed, and medical school freshman GPAs weresignificantly associated with the USMLE Step 1performances. The study results confirmed that MCATscores and medical school course performances weresignificant predictors of the USMLE Step 1 (Chen et al.,2001; and Haught and Walls, 2002). The implication of thestudy results was that the medical school should continueits effort to recruit and admit qualifying students with highMCA T scores, and to strengthen teaching and learning toensure student success on the licensure examination.With regard to Cox regression analysis, the methodindicated that academic difficulty was significantlyaccounted for by risk factors such as MCA T verbalreasoning score, gender, and number of sophomore coursesfailed. Moreover, students in the five-year curriculum trackexperienced academic difficulty during the first semesterof their sophomore year, peaked at the second semesterof the sophomore year and maintained the same level ofrisk through the rest of the study period. The researchresults were consistent with the literature stating that anincrease in the relative risk for a student experiencingacademic difficulty was significantly associated with a lowMCA T score (Huff and Fang, 1999), and students at riskfor academic difficulty remained at risk throughout the firstthree years of medical school (Fang, 2000). The implicationof this study was that the medical school addressedacademic difficulty issues through academic developmentand support services.在这项研究中,完成了构建Logistic和Cox回归模型的主要目标。

科技文献检索参考试卷

《科技文献检索》试卷本试题一共4道大题,共5页,满分100分。

阅卷人题号一二三四合计核分人题分30 30 20 20 100总分得分一、单项选择题(请将正确答案的序号填在括号内,每题1.5分,共30分)1. 文献是记录有知识的( A )A 载体B 纸张C 光盘D 磁盘2. 下列哪种文献属于一次文献( A )A 期刊论文B 百科全书C 综述D 文摘3. 下列哪种文献属于二次文献(D )A 专利文献B 学位论文C 会议文献D 目录4. 下列哪种文献属于三次文献( C )A 标准文献B 学位论文C 综述D 文摘5. 下列选项中属于连续出版物类型的选项有(A )A 图书B 学位论文C 科技期刊D 会议文献6. 下列选项中属于特种文献类型的有(D )A 报纸B 图书C 科技期刊D 标准文献7. 纸质信息源的载体是(D)A 光盘B 缩微平片C 感光材料D 纸张8. 以刊载新闻和评论为主的文献是( B )A 图书B 报纸C 期刊D 会议文献9. 使用分类语言对信息进行描述和标引,主要是可以把( B )的信息集中在一起。

A 同一作者B 同一学科C 同一主题D A+B+C10.《中国图书馆分类法》(简称《中图法》)将图书分成( A )A 5大部分22个大类B 5大部分26个大类C 6大部分22个大类D 6大部分26个大类11.《中国图书分类法》(简称《中图法》)是我国常用的分类法,要检索农业方面的图书,需要在( A )类目下查找。

A S类目B Q类目C T 类目D R类目12. 利用文献末尾所附参考文献进行检索的方法是(C )A 倒查法B 顺查法C 引文追溯法D 抽查法13. 至少由一种文档组成,并能满足某一特定目的或某一特定数据处理系统需要的一种数据集合,称为( A )A 数据库B 记录C 字段D 文档14. 广义的信息检索包含两个过程( B )A 检索与利用B 存储与检索C 存储与利用D 检索与报道15. 狭义的专利文献是指( C )A 专利公报B 专利目录 C专利说明书 D 专利索引16. 中国国家标准的代码是( A )A GB B CBC ZGD CG17. 我校图书馆所购买的下列数据库中可以检索期刊论文的是( A )A 万方数据库资源系统B 超星数字图书馆C 书生之家数字图书馆D 方正Apabi数字图书馆18. 期刊论文记录中的“文献出处”字段是指:(C )A 论文的作者B 论文作者的工作单位C 刊载论文的期刊名称及年卷期、起止页码D 收录论文的数据库19. 以下四种信息检索语言中,不受《词表》控制的是( A )A 标题词语言B 元词语言C 叙词语言D 关键词语言20. 以下检索出文献最少的检索式是( C )A a and bB a and b or cC a and b and cD (a or b) and c二、填空题:(每空1分,共30分)1. 文献按其加工深度不同可以划分为一次文献、二次文献、三次文献和零次文献。

法布里珀罗基模共振英文

法布里珀罗基模共振英文The Fabryperot ResonanceOptics, the study of light and its properties, has been a subject of fascination for scientists and researchers for centuries. One of the fundamental phenomena in optics is the Fabry-Perot resonance, named after the French physicists Charles Fabry and Alfred Perot, who first described it in the late 19th century. This resonance effect has numerous applications in various fields, ranging from telecommunications to quantum physics, and its understanding is crucial in the development of advanced optical technologies.The Fabry-Perot resonance occurs when light is reflected multiple times between two parallel, partially reflective surfaces, known as mirrors. This creates a standing wave pattern within the cavity formed by the mirrors, where the light waves interfere constructively and destructively to produce a series of sharp peaks and valleys in the transmitted and reflected light intensity. The specific wavelengths at which the constructive interference occurs are known as the resonant wavelengths of the Fabry-Perot cavity.The resonant wavelengths of a Fabry-Perot cavity are determined bythe distance between the mirrors, the refractive index of the material within the cavity, and the wavelength of the incident light. When the optical path length, which is the product of the refractive index and the physical distance between the mirrors, is an integer multiple of the wavelength of the incident light, the light waves interfere constructively, resulting in a high-intensity transmission through the cavity. Conversely, when the optical path length is not an integer multiple of the wavelength, the light waves interfere destructively, leading to a low-intensity transmission.The sharpness of the resonant peaks in a Fabry-Perot cavity is determined by the reflectivity of the mirrors. Highly reflective mirrors result in a higher finesse, which is a measure of the ratio of the spacing between the resonant peaks to their width. This high finesse allows for the creation of narrow-linewidth, high-resolution optical filters and laser cavities, which are essential components in various optical systems.One of the key applications of the Fabry-Perot resonance is in the field of optical telecommunications. Fiber-optic communication systems often utilize Fabry-Perot filters to select specific wavelength channels for data transmission, enabling the efficient use of the available bandwidth in fiber-optic networks. These filters can be tuned by adjusting the mirror separation or the refractive index of the cavity, allowing for dynamic wavelength selection andreconfiguration of the communication system.Another important application of the Fabry-Perot resonance is in the field of laser technology. Fabry-Perot cavities are commonly used as the optical resonator in various types of lasers, providing the necessary feedback to sustain the lasing process. The high finesse of the Fabry-Perot cavity allows for the generation of highly monochromatic and coherent light, which is crucial for applications such as spectroscopy, interferometry, and precision metrology.In the realm of quantum physics, the Fabry-Perot resonance plays a crucial role in the study of cavity quantum electrodynamics (cQED). In cQED, atoms or other quantum systems are placed inside a Fabry-Perot cavity, where the strong interaction between the atoms and the confined electromagnetic field can lead to the observation of fascinating quantum phenomena, such as the Purcell effect, vacuum Rabi oscillations, and the generation of nonclassical states of light.Furthermore, the Fabry-Perot resonance has found applications in the field of optical sensing, where it is used to detect small changes in physical parameters, such as displacement, pressure, or temperature. The high sensitivity and stability of Fabry-Perot interferometers make them valuable tools in various sensing and measurement applications, ranging from seismic monitoring to the detection of gravitational waves.The Fabry-Perot resonance is a fundamental concept in optics that has enabled the development of numerous advanced optical technologies. Its versatility and importance in various fields of science and engineering have made it a subject of continuous research and innovation. As the field of optics continues to advance, the Fabry-Perot resonance will undoubtedly play an increasingly crucial role in shaping the future of optical systems and applications.。

  1. 1、下载文档前请自行甄别文档内容的完整性,平台不提供额外的编辑、内容补充、找答案等附加服务。
  2. 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
  3. 3、如文档侵犯您的权益,请联系客服反馈,我们会尽快为您处理(人工客服工作时间:9:00-18:30)。

Original Paper__________________________________________________________Forma, 22, 55–64, 2007 Extended Pasting Scheme for Kolam Pattern GenerationThamburaj R OBINSONDepartment of Mathematics, Madras Christian College, Chennai 600 059, IndiaE-mail address: robin.mcc@(Received November 3, 2006; Accepted September 5, 2007)Keywords: Kolam Patterns, Picture Language, Tessellation Abstract. The theory of “Formal Languages” had been applied successfully to study theaspect of generating patterns of the kolam folk designs. In this paper a new picturegenerating method by the use of pasting of tiles is presented. The generating model“Pasting Scheme” and its variant “Extended Pasting Scheme” are shown to generatepatterns including kolams of kambi and non-kambi types and tessellations as well.1. IntroductionKolam is a traditional art of decorating courtyards, temples and prayer rooms in South India drawn mainly by womenfolk. Some women use rice flour to draw a kolam, which is a traditional medium to be used while others use limestone powder. During festivals and weddings, rice flour paste is used instead of the flour. This tradition of decorating with kolams is passed on from generation to generation. Generally dots are drawn first on the floor and then depending on the type of kolam, lines are drawn either connecting the dots or going around the dots and complete as closed curves (Fig. 1). The patterns where the lines are drawn around the dots are called as kambi kolams as they look like wire decoration (kambi means “wire” in Tamil). There are many interesting and complicated designs made up of a single or many closed curves.These traditional designs also seem to imbibe mathematical properties such as symmetry, permutation etc. The ethno-mathematical view and the corresponding study of kolam patterns have been done extensively by A SCHER (1991) and G ERDES (1989). As early as 1974, Rosenfeld advocated a cycle grammar for generation and description of pictures having rotational symmetry. Kambi kolam patterns, fractals provided interesting examples of cycle languages. Kolam designs as examples of two-dimensional picture languages with formally definable syntactic rules, the formal properties of such languages have been studied by S IROMONEY et al. (1972). Motivated by the koam designs, S IROMONEY et al. (1974) have introduced different types of array grammars generating array languages and also have given specific instructions for drawing certain kinds of kolam patterns using Turtle motions with chain-code interpretation and kolam motions with cycle rewriting rules (S IROMONEY and S IROMONE, 1987; S IROMONEY et al., 1989). Independent of her5556T. R OBINSONstudies, computer programs for mechanical or interactive generation of kolam patterns have also been attempted by N AGATA and Y ANAGISAWA (2004) by the use of other underlying syntax rules and a digital expression for representing Kambi Kolam patterns as well. Recently N AGATA and R OBINSON (2006) have extended the applicability of Kolam designs as tangible pictures for the people with disability.On the other hand, the art of tiling has been in vogue very early in human civilization.Intricate tiling patterns were used to decorate and cover floors and walls. Motivated by the problems in tiling, N IVAT et al . (1995) proposed Puzzle grammars for generating connected arrays of square cells and investigated theoretical questions. A study on tiling patterns by the use of pasting of square tiles at their edges has been done by R OBINSON (2002).K ALYANI et al . (2006) extended this notion to isosceles triangles and studied certain decidability results. R AGHAVACHARY has used arrangement of diamond shaped tiles by placing them corner to corner to form kolam patterns.In this paper yet another generating mechanism namely “Pasting Scheme” (PS) and its variant “Extended Pasting Scheme” (EPS) for kolam patterns have been proposed by the use of the notion of pasting of tiles along the specified edges. PS and EPS make use of triangle, square or hexagon tiles, a set of pasting rules for the tiles and a set of constraints.The generative capacity of these models is higher when they include non-kambi kolam patterns too. Finally, irregular polygons as tiles are used to generate patterns, and a tessellation that fills the unbounded space is also attempted.2. Basic DefinitionsSome basic definitions concerning tiles are recollected and necessary notions areillustrated in this section.Fig. 1. Women drawing kolam patterns (photo courtesy: Kamat ’s Potpourri).Extended Pasting Scheme for Kolam Pattern Generation 572.1. TileA tile is a two-dimensional topological disk (region) whose boundary is a single simple closed curve whose ends join up to form a loop without crossing or branches.2.2. TilingA plane tiling is a countable family of topological disks which cover the Euclidean plane without gaps or overlaps.From the definition of tiling, it is clear that the intersection of any finite set of tiles in a tiling has necessarily zero area. Such an intersection will consist of a set of points called vertices and lines called edges. Two tiles are called adjacent if they have an edge in common.A tile, its vertices and edges may be labeled distinctively. A decorated tile is one whose region is engraved or drawn with any picture/colored pattern/design. A decorated hexagonal tile, a decorated square tile with its edge labels and a decorated square tile with colored patterns are shown in Fig. 2. The boundary of a tile is the sequence of edges taken around adbcad bcFig. 2. Decorated hexagonal and square tiles.Fig. 3. A tiling pattern with five pasted tiles.58T. R OBINSONthe tile in order (generally, anti-clockwise). The boundary edges of second and third tiles of Fig. 2 are the sequence “abcd”.2.3. Pasting ruleA pasting rule is concerned to a pair of edges of tiles that allows the edges of the corresponding tiles to get glued or attached at those edges. When tiles are attached by pasting rules it results in formation of tiling. The boundary of a tiling is the sequence of edges of the tiles that are exposed to the environment. The pasting rules {(a, c), (b, d)}, which means that the two edges (a, c) are pasted to the two edges (b, d) respectively, are applied to the edges of the tile shown in Fig. 2(c) to obtain a tiling pattern shown in Fig.3. The boundary of the tiling is “ababcbcdcdad”3. Pasting Scheme for Picture GenerationThe formal definitions for Pasting Scheme, Extended Pasting Scheme and derivation of language of tiling patterns by these schemes are given here. Both systems are illustrated with examples to generate kolam patterns and tessellation.3.1. Pasting SchemeA “Pasting Scheme” (PS) is defined as a 3-tuple, G = (T, P, w0) where T is finite non-empty set of tiles with labeled edges, P is a finite set of pasting rules and w0 is the axiom tile or tiling.By applying pasting rules to the edges of a tile or a tiling t i, a new tiling t i+1 is said to be obtained (or derived) from t i. It is symbolically denoted as t i⇒t i+1. Subsequently, the pasting of tiles can be done along the edges of t i+1 to derive further tiling patterns. The set of all tiling patterns, L(G) obtained from the given axiom w0 in a pasting system G is called the language of G. Hence, L(G) = {t i : w0⇒* t i} where ⇒* is the reflexive, transitive closure of ⇒. Pasting rules can be applied to all the boundary edges of a tiling t i simultaneously (parallel application) or sequentially to one edge of t i at a time. The language of G derived by parallel application of pasting rules is denoted as L P(G), whereas the language obtained by sequential derivation is denoted as L S(G). It is obvious that L P(G)ʚ L S(G).3.2. Extended Pasting SchemeAn “Extended Pasting Scheme” (EPS) is defined as a 4-tuple, H = (T, P, w0, ∆) where T is finite non-empty set of tiles with labeled edges, P is a finite set of pasting rules, w0 is the axiom tile or tiling and ∆ is a finite set of constraints on the edge labels of T. L(H) is the set of tiling patterns obtained from the axiom w0 subject to the constraints given in ∆. In other words, the L(H) has all the tiling patterns derived from the axiom which satisfy the conditions of ∆. The application of pasting rules can be either parallel or sequential and hence L P(H), L S(H) are obtained accordingly. It can be seen that L P(G) = L P(H) and L S(G) = L S(H) if ∆ = Φ.Example 1.Consider the PS, G1 = (T, {(14, 22), (14, 32), (24, 32)}, w0) where T is set of threeExtended Pasting Scheme for Kolam Pattern Generation59decorated square tiles and w 0 is the axiom as shown in Fig. 4. The first four members of the tiling patterns (Border kambi kolam) generated by sequential derivation from the axiom tile is shown in Fig. 5. The patterns engraved on the tiles are highlighted in the derivation of new patterns and not the bounding edges of the pasted tiles. It can be noted that the first and third members in the sequence do not have the smooth curves in the boundary. The PS generates the set of patterns as defined by the pasting rules and it has no control mechanismto generate certain desired patterns. The Extended Pasting System however, has a control211112131423243133342232w 0 =, ,,,Fig. 4. The set of tiles and the axiom for G 1.Fig. 5. A sequence of Border kambi kolam patterns.,w 0 =Fig. 6. The first two members by EPS H 1.60T. R OBINSONto choose certain patterns based on the constraints. In this paper the constraints are used on the boundary labels of the tiling patterns.Example 2.Consider the EPS, H 1 = (T 1, {(a , d ), (b , c )}, w 0, ∆1) where T 1 is the square tile as shown in Fig. 2 and ∆1 = {a , b }+ on boundary of tiling patterns (i.e. the boundary labels of each tiling pattern should be made of a ’s and b ’s only). The kambi kolam patterns are generated in parallel and the first two members (including the given axiom) of the sequence are shown in Fig. 6.Example 3.Consider the EPS H 2 = (T 2, {(a , a ), (b , b ), (c , c )}, w 0, ∆2) where T 2 is the hexagonal,b b bbba b Fig. 7. The first three members by EPS H 2.Fig. 8. Hexagon and parallelogram tiles.Extended Pasting Scheme for Kolam Pattern Generation61,Fig. 9. Mango leaves kolam patterns.Fig. 10. A tessellation pattern.colored tile (as well as the axiom w 0) and ∆2 = {(ab )n (ca )n (bc )n /n ≥ 1}. The first three members generated sequentially as per the constraint are shown in Fig. 7.Example 4.In this example we use irregular polygon tiles to generate a language of kolam patterns (known as “Mango leaves ”). The EPS H 3 = (T 3, {(a , a ), (b , b )}, w 0, ∆3) where T 3 consists62T. R OBINSONb d feab cdFig. 11. The triangular axiom tiles.Fig. 12. A decorated rectangular tile.of a regular hexagon (axiom) and a parallelogram with six labeled edges as shown in Fig.8.When ∆3 = {(ba 2(b 2a 2)n )6/n ≥ 0}, a sequence of patterns with three axes of symmetry is generated. The Mango leaves kolam patterns which have single axis symmetry are obtained if ∆3 = {(ba 2b )n a 2ba 2(b 2a 2)n –1(ba 2b )n a 2ba 2(b 2a 2)n –1/n ≥ 1}. The first three members generated sequentially are shown in Fig. 9.Example 5.The derivation of the patterns with no bounding constraints may fill the regions in the Euclidean plane in the limiting case. The tessellation patterns can be generated thus with unlimited boundary constraint (denoted as ∞). For the EPS H 2 considered in Example 3,with ∆3 = ∞ the (unbounded) tessellation pattern is generated in the limiting case. A portion of the tessellation is shown in Fig. 10.The tessellation can be generated with two triangular tiles instead of the hexagonal tile by the rules {(a , d ), (b , e ), (c , f )} and ∆3 = ∞ with any of the two tiles (Fig. 11) as axiom.Example 6.Consider the EPS H 4 = (T 4, {(a , c ), (b , d )}, w 0, ∆4) where the axiom tile is a colored rectangle tile as shown in Fig. 12 and ∆4 = {a n b m c n d m /n , m ≥ 1}. The language thus generated has the set of all rectangles of area mn square units. One member of the language is shown in Fig. 13.Extended Pasting Scheme for Kolam Pattern Generation 634. ConclusionA new type of generating system has been introduced in this paper to generate patterns including tessellations, and the suitability of generating kambi and non-kambi kolam pictures has been highlighted. The picture language theoretic study with deterministic pasting rules and decidability results and extension of this notion to pasting of cuboids to form patterns on non-planar surfaces are worth pursuing.REFERENCESA SCHER , M. (1991) Ethnomathematics—A Multicultural View of Mathematical Ideas , Pacific Grove: Brooks &Cole.G ERDES , P. (1989) Reconstruction and extension of lost symmetries: Examples from Tamil of South India,Comp. Math. Applic ., 17, No. 4–6, 791–813.K ALYANI , T., S ASIKALA , K., D ARE , V. R., A BISHA , P. J. and R OBINSON , T. (2006) Triangular pasting system,in Formal Models, Languages and Applications (Eds. K. G. Subramanian, K. Rangarajan and M. Mukund),Series in Machine Perception and Artificial Intelligence , Vol. 66, pp. 195–211, World Scientific.N AGATA , S. and R OBINSON , T. (2006) Digitalization of kolam patterns and tactile kolam tools, in FormalModels, Languages and Applications (Eds. K. G. Subramanian, K. Rangarajan and M. Mukund), Series in Machine Perception and Artificial Intelligence , Vol. 66, pp. 353–362, World Scientific.N AGATA , S. and Y ANAGISAWA , K. (2004) Attractiveness of Kolam design —Characteristics of single strokecycle, Bulletin of the Society for Science on Form in Japan , 19, No. 2, 221–222.N IVAT , M., Saoudi, A., S UBRAMANIAN , K. G., S IROMONEY , R. and D ARE , V. R. (1995) International Journal ofPattern Recognition and Artificial Intelligence , 5, 663 pp.R AGHAVACHARY , S., Tile-Based Kolam Patterns , Dream Works Feature Animation.R OBINSON , T. (2002) A study on circular languages, patterns and map systems, Doctoral Thesis, University ofMadras, Chennai.Fig. 13. A tessellation pattern from EPS H 4.64T. R OBINSONS IROMONEY, G. and S IROMONEY, R. (1987) Rosenfeld’s cycle grammars and kolam, in Lecture Notes in Computer Science 291, pp. 564-579, Springer.S IROMONEY, G., S IROMONEY, R. and K RITHIVASAN, K. (1972) Abstract families of matrices and picture languages, Computer Graphics and Image Processing, 1, 234–307.S IROMONEY, G., S IROMONEY, R. and K RITHIVASAN, K. (1974) Array grammars and kolam, Computer Graphics and Image Processing, 3, 63-82.S IROMONEY, G., S IROMONEY, R. and R OBINSON, T. (1989) Kambi kolam and cycle grammars, in A Perspective in Theoretical Computer Science (Ed. R. Narasimhan), Series in Computer Science, Vol. 16, pp. 267-300, World Scientific.。

相关文档
最新文档