Analytical regularisation for confined quantum fields between parallel surfaces
一章节绪论000003

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§1.4.2 试样分解试样预处理
➢ 目的是利用有效的手段将样品处理成便于分 析的待测样品;
➢ 与待测样品有关的因素: ➢ 分析方法(常量、微量); ➢ 物态与相(多相、均相、固态、液态、气
态); ➢ 待测成分在样品中的含量(针对不同的分
析方法)。 ➢ 试样处理方法的原则: ➢ 利用样品化学、物理性质的不同; ➢ 适应测定方法和要求的不同。 ➢ *必要时要进行样品的分离与富集。
➢ 分析化学定量发展史则是从贝格曼 他制定了湿法分析矿物详细的步骤开始 的,他所倡导的一些反应直到现在仍在 分析化学中保留。而创建酸碱滴定法的 则是法国人日夫鲁瓦;氧化还原滴定法 始于18世纪末,1795年由法国人德克 劳西以靛蓝的硫酸溶液滴定次氯酸,至 溶液颜色变绿为止,是最早的氧化还原 法。
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光度分析由于简单方便, 成本低廉, 灵敏度、
选择性、准确度均有一定优势, 在痕量分析中
适应于市场竞争, 成为适合我国国情有中国特
色的分析领域之一.
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5. 化学计量学在分析化学中的应用
化学计量学(Chemometrics) 是由数学、统 计学、计算机技术与化学相结合的交叉科学, 化学计量学能有效地解决许多常规方法难于 解决的复杂问题, 化学计量学在分析化学中 的应用主要有以下几个方面:
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§1.2.3 按试样用量和被测组分含量分 类
常量分析 微量分析 痕量
试样质量m >0.1g 0.1~10mg <0.1mg
试样含量wx >1% 0.01~1% <0.01%
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Eurachem Guide. The fitness for purpose of analytical methods.

Dr J Morkowski
EMPA, Switzerland
Dr B te Nijenhuis
Working Party on Analytical Chemistry (Secretary), The Netherlands
Ms B Nyeland Dr R Philipp
National Environment Research Institute, Denmark BAM, Germany
The Fitness for Purpose of Analytical Methods
EURACHEM Guide
The Fitness for Purpose of Analytical Methods
A Laboratory Guide to Method Validation and Related Topics
i
production and distribution of new editions of this guide should be directed to the EURACHEM Secretariats
This edition is Copyright © LGC (Teddington) Ltd, 1998
4. “There should be a regular independent assessment of the technical performance of a laboratory”
Dr M Lauwaars
AOAC International, The Netherlands
Dr B Lundgren
SP, Sweden
Prof L Massart Prof J Miller
201507FDA行业指南:分析方法验证(中英文)(下)

201507FDA行业指南:分析方法验证(中英文)(下)VII. STATISTICAL ANALYSIS AND MODELS 统计学分析和模型A. Statistics 统计学Statistical analysis of validation data can be used to evaluate validation characteristics against predetermined acceptance criteria. All statistical procedures and parameters used in the analysis of the data should be based on sound principles and appropriate for the intended evaluation. Several statistical methods are useful for assessing validation characteristics, for example, an analysis of variance (ANOVA) to assess regression analysis R (correlation coefficient) and R squared (coefficient of determination) or linear regression to measure linearity. Many statistical methods used for assessing validation characteristics rely on population normality, and it is important to determine whether or not to reject this assumption. There are many techniques, such as histograms, normality tests, and probability plots that can be used to evaluate the observed distribution. It may be appropriate to transform the data to better fit the normal distribution or apply distribution-free (nonparametric) approaches when the observed data are not normally distributed. Appropriate literature or text should be consulted for information on statistical procedures to use when developing new test methods, evaluating existing test methods or evaluating measurement system performance, as well as other general information on the interpretation and treatment of analytical data[18].The data analysis should be assured either by using appropriately validated software or independent verification for correctness.验证数据的统计学分析可以用于评估验证的属性是否符合预定的可接受标准。
药物分析英语词汇

药物分析英语词汇Abbe refractometer 阿贝折射仪absorbance 吸收度absorbance ratio 吸收度比值absorption 吸收absorption curve 吸收曲线absorption spectrum 吸收光谱absorptivity 吸收系数accuracy 准确度acid-dye colorimetry 酸性染料比色法acidimetry 酸量法acid-insoluble ash 酸不溶性灰分acidity 酸度activity 活度additive 添加剂additivity 加和性adjusted retention time 调整保留时间adsorbent 吸附剂adsorption 吸附affinity chromatography 亲和色谱法aliquot (一)份alkalinity 碱度alumina 氧化铝ambient temperature 室温ammonium thiocyanate 硫氰酸铵analytical quality control(AQC)分析质量控制anhydrous substance 干燥品anionic surfactant titration 阴离子表面活性剂滴定法antibiotics-microbial test 抗生素微生物检定法antioxidant 抗氧剂appendix 附录application of sample 点样area normalization method 面积归一化法argentimetry 银量法arsenic 砷arsenic stain 砷斑ascending development 上行展开ash-free filter paper 无灰滤纸(定量滤纸)assay 含量测定assay tolerance 含量限度atmospheric pressure ionization(API) 大气压离子化attenuation 衰减back extraction 反萃取back titration 回滴法bacterial endotoxins test 细菌内毒素检查法band absorption 谱带吸收baseline correction 基线校正baseline drift 基线漂移batch, lot 批batch(lot) number 批号Benttendorff method 白田道夫(检砷)法between day (day to day, inter-day) precision 日间精密度between run (inter-run) precision 批间精密度biotransformation 生物转化bioavailability test 生物利用度试验bioequivalence test 生物等效试验biopharmaceutical analysis 体内药物分析,生物药物分析blank test 空白试验boiling range 沸程British Pharmacopeia (BP) 英国药典bromate titration 溴酸盐滴定法bromimetry 溴量法bromocresol green 溴甲酚绿bromocresol purple 溴甲酚紫bromophenol blue 溴酚蓝bromothymol blue 溴麝香草酚蓝bulk drug, pharmaceutical product 原料药buret 滴定管by-product 副产物calibration curve 校正曲线calomel electrode 甘汞电极calorimetry 量热分析capacity factor 容量因子capillary zone electrophoresis (CZE) 毛细管区带电泳capillary gas chromatography 毛细管气相色谱法carrier gas 载气cation-exchange resin 阳离子交换树脂ceri(o)metry 铈量法characteristics, description 性状check valve 单向阀chemical shift 化学位移chelate compound 鳌合物chemically bonded phase 化学键合相chemical equivalent 化学当量Chinese Pharmacopeia (ChP) 中国药典Chinese material medicine 中成药Chinese materia medica 中药学Chinese materia medica preparation 中药制剂Chinese Pharmaceutical Association (CPA) 中国药学会chiral 手性的chiral stationary phase (CSP) 手性固定相chiral separation 手性分离chirality 手性chiral carbon atom 手性碳原子chromatogram 色谱图chromatography 色谱法chromatographic column 色谱柱chromatographic condition 色谱条件chromatographic data processor 色谱数据处理机chromatographic work station 色谱工作站clarity 澄清度clathrate, inclusion compound 包合物clearance 清除率clinical pharmacy 临床药学coefficient of distribution 分配系数coefficient of variation 变异系数color change interval (指示剂)变色范围color reaction 显色反应colorimetric analysis 比色分析colorimetry 比色法column capacity 柱容量column dead volume 柱死体积column efficiency 柱效column interstitial volume 柱隙体积column outlet pressure 柱出口压column temperature 柱温column pressure 柱压column volume 柱体积column overload 柱超载column switching 柱切换committee of drug evaluation 药品审评委员会comparative test 比较试验completeness of solution 溶液的澄清度compound medicines 复方药computer-aided pharmaceutical analysis 计算机辅助药物分析concentration-time curve 浓度-时间曲线confidence interval 置信区间confidence level 置信水平confidence limit 置信限congealing point 凝点congo red 刚果红(指示剂)content uniformity 装量差异controlled trial 对照试验correlation coefficient 相关系数contrast test 对照试验counter ion 反离子(平衡离子)cresol red 甲酚红(指示剂)crucible 坩埚crude drug 生药crystal violet 结晶紫(指示剂)cuvette, cell 比色池cyanide 氰化物cyclodextrin 环糊精cylinder, graduate cylinder, measuring cylinder 量筒cylinder-plate assay 管碟测定法daughter ion (质谱)子离子dead space 死体积dead-stop titration 永停滴定法dead time 死时间decolorization 脱色decomposition point 分解点deflection 偏差deflection point 拐点degassing 脱气deionized water 去离子水deliquescence 潮解depressor substances test 降压物质检查法derivative spectrophotometry 导数分光光度法derivatization 衍生化descending development 下行展开desiccant 干燥剂detection 检查detector 检测器developer, developing reagent 展开剂developing chamber 展开室deviation 偏差dextrose 右旋糖,葡萄糖diastereoisomer 非对映异构体diazotization 重氮化2,6-dichlorindophenol titration 2,6-二氯靛酚滴定法differential scanning calorimetry (DSC) 差示扫描热量法differential spectrophotometry 差示分光光度法differential thermal analysis (DTA) 差示热分析differentiating solvent 区分性溶剂diffusion 扩散digestion 消化diphastic titration 双相滴定disintegration test 崩解试验dispersion 分散度dissolubility 溶解度dissolution test 溶出度检查distilling range 馏程distribution chromatography 分配色谱distribution coefficient 分配系数dose 剂量drug control institutions 药检机构drug quality control 药品质量控制drug release 药物释放度drug standard 药品标准drying to constant weight 干燥至恒重dual wavelength spectrophotometry 双波长分光光度法duplicate test 重复试验effective constituent 有效成分effective plate number 有效板数efficiency of column 柱效electron capture detector 电子捕获检测器electron impact ionization 电子轰击离子化electrophoresis 电泳electrospray interface 电喷雾接口electromigration injection 电迁移进样elimination 消除eluate 洗脱液elution 洗脱emission spectrochemical analysis 发射光谱分析enantiomer 对映体end absorption 末端吸收end point correction 终点校正endogenous substances 内源性物质enzyme immunoassay(EIA) 酶免疫分析enzyme drug 酶类药物enzyme induction 酶诱导enzyme inhibition 酶抑制eosin sodium 曙红钠(指示剂)epimer 差向异构体equilibrium constant 平衡常数equivalence point 等当点error in volumetric analysis 容量分析误差excitation spectrum 激发光谱exclusion chromatography 排阻色谱法expiration date 失效期external standard method 外标法extract 提取物extraction gravimetry 提取重量法extraction titration 提取容量法extrapolated method 外插法,外推法factor 系数,因数,因子feature 特征Fehling’s reaction 费林反应field disorption ionization 场解吸离子化field ionization 场致离子化filter 过滤,滤光片filtration 过滤fineness of the particles 颗粒细度flame ionization detector(FID) 火焰离子化检测器flame emission spectrum 火焰发射光谱flask 烧瓶flow cell 流通池flow injection analysis 流动注射分析flow rate 流速fluorescamine 荧胺fluorescence immunoassay(FIA) 荧光免疫分析fluorescence polarization immunoassay(FPIA) 荧光偏振免疫分析fluorescent agent 荧光剂fluorescence spectrophotometry 荧光分光光度法fluorescence detection 荧光检测器fluorimetyr 荧光分析法foreign odor 异臭foreign pigment 有色杂质formulary 处方集fraction 馏分freezing test 结冻试验funnel 漏斗fused peaks, overlapped peaks 重叠峰fused silica 熔融石英gas chromatography(GC) 气相色谱法gas-liquid chromatography(GLC) 气液色谱法gas purifier 气体净化器gel filtration chromatography 凝胶过滤色谱法gel permeation chromatography 凝胶渗透色谱法general identification test 一般鉴别试验general notices (药典)凡例general requirements (药典)通则good clinical practices(GCP) 药品临床管理规范good laboratory practices(GLP) 药品实验室管理规范good manufacturing practices(GMP) 药品生产质量管理规范good supply practices(GSP) 药品供应管理规范gradient elution 梯度洗脱grating 光栅gravimetric method 重量法Gutzeit test 古蔡(检砷)法half peak width 半峰宽[halide] disk method, wafer method, pellet method 压片法head-space concentrating injector 顶空浓缩进样器heavy metal 重金属heat conductivity 热导率height equivalent to a theoretical plate 理论塔板高度height of an effective plate 有效塔板高度high-performance liquid chromatography (HPLC) 高效液相色谱法high-performance thin-layer chromatography (HPTLC) 高效薄层色谱法hydrate 水合物hydrolysis 水解hydrophilicity 亲水性hydrophobicity 疏水性hydroscopic 吸湿的hydroxyl value 羟值hyperchromic effect 浓色效应hypochromic effect 淡色效应identification 鉴别ignition to constant weight 灼烧至恒重immobile phase 固定相immunoassay 免疫测定impurity 杂质inactivation 失活index 索引indicator 指示剂indicator electrode 指示电极inhibitor 抑制剂injecting septum 进样隔膜胶垫injection valve 进样阀instrumental analysis 仪器分析insulin assay 胰岛素生物检定法integrator 积分仪intercept 截距interface 接口interference filter 干涉滤光片intermediate 中间体internal standard substance 内标物质international unit(IU) 国际单位in vitro 体外in vivo 体内iodide 碘化物iodoform reaction 碘仿反应iodometry 碘量法ion-exchange cellulose 离子交换纤维素ion pair chromatography 离子对色谱ion suppression 离子抑制ionic strength 离子强度ion-pairing agent 离子对试剂ionization 电离,离子化ionization region 离子化区irreversible indicator 不可逆指示剂irreversible potential 不可逆电位isoabsorptive point 等吸收点isocratic elution 等溶剂组成洗脱isoelectric point 等电点isoosmotic solution 等渗溶液isotherm 等温线Karl Fischer titration 卡尔·费歇尔滴定kinematic viscosity 运动黏度Kjeldahl method for nitrogen 凯氏定氮法Kober reagent 科伯试剂Kovats retention index 科瓦茨保留指数labelled amount 标示量leading peak 前延峰least square method 最小二乘法leveling effect 均化效应licensed pharmacist 执业药师limit control 限量控制limit of detection(LOD) 检测限limit of quantitation(LOQ) 定量限limit test (杂质)限度(或限量)试验limutus amebocyte lysate(LAL) 鲎试验linearity and range 线性及范围linearity scanning 线性扫描liquid chromatograph/mass spectrometer (LC/MS) 液质联用仪litmus paper 石蕊试纸loss on drying 干燥失重low pressure gradient pump 低压梯度泵luminescence 发光lyophilization 冷冻干燥main constituent 主成分make-up gas 尾吹气maltol reaction 麦牙酚试验Marquis test 马奎斯试验mass analyzer detector 质量分析检测器mass spectrometric analysis 质谱分析mass spectrum 质谱图mean deviation 平均偏差measuring flask, volumetric flask 量瓶measuring pipet(te) 刻度吸量管medicinal herb 草药melting point 熔点melting range 熔距metabolite 代谢物metastable ion 亚稳离子methyl orange 甲基橙methyl red 甲基红micellar chromatography 胶束色谱法micellar electrokinetic capillary chromatography(MECC, MEKC) 胶束电动毛细管色谱法micelle 胶束microanalysis 微量分析microcrystal 微晶microdialysis 微透析micropacked column 微型填充柱microsome 微粒体microsyringe 微量注射器migration time 迁移时间millipore filtration 微孔过滤minimum fill 最低装量mobile phase 流动相modifier 改性剂,调节剂molecular formula 分子式monitor 检测,监测monochromator 单色器monographs 正文mortar 研钵moving belt interface 传送带接口multidimensional detection 多维检测multiple linear regression 多元线性回归multivariate calibration 多元校正natural product 天然产物Nessler glasses(tube) 奈斯勒比色管Nessler’s reagent 碱性碘化汞钾试液neutralization 中和nitrogen content 总氮量nonaqueous acid-base titration 非水酸碱滴定nonprescription drug, over the counter drugs (OTC drugs) 非处方药nonproprietary name, generic name 非专有名nonspecific impurity 一般杂质non-volatile matter 不挥发物normal phase 正相normalization 归一化法notice 凡例nujol mull method 石蜡糊法octadecylsilane chemically bonded silica 十八烷基硅烷键合硅胶octylsilane 辛(烷)基硅烷odorless 无臭official name 法定名official specifications 法定标准official test 法定试验on-column detector 柱上检测器on-column injection 柱头进样on-line degasser 在线脱气设备on the dried basis 按干燥品计opalescence 乳浊open tubular column 开管色谱柱optical activity 光学活性optical isomerism 旋光异构optical purity 光学纯度optimization function 优化函数organic volatile impurities 有机挥发性杂质orthogonal function spectrophotometry 正交函数分光光度法orthogonal test 正交试验orthophenanthroline 邻二氮菲outlier 可疑数据,逸出值overtones 倍频峰,泛频峰oxidation-reduction titration 氧化还原滴定oxygen flask combustion 氧瓶燃烧packed column 填充柱packing material 色谱柱填料palladium ion colorimetry 钯离子比色法parallel analysis 平行分析parent ion 母离子particulate matter 不溶性微粒partition coefficient 分配系数parts per million (ppm) 百万分之几pattern recognition 模式识别peak symmetry 峰不对称性peak valley 峰谷peak width at half height 半峰宽percent transmittance 透光百分率pH indicator absorbance ratio method pH指示剂吸光度比值法pharmaceutical analysis 药物分析pharmacopeia 药典pharmacy 药学phenolphthalein 酚酞photodiode array detector(DAD) 光电二极管阵列检测器photometer 光度计pipeclay triangle 泥三角pipet(te) 吸移管,精密量取planar chromatography 平板色谱法plate storage rack 薄层板贮箱polarimeter 旋光计polarimetry 旋光测定法polarity 极性polyacrylamide gel 聚丙酰胺凝胶polydextran gel 葡聚糖凝胶polystyrene gel 聚苯乙烯凝胶polystyrene film 聚苯乙烯薄膜porous polymer beads 高分子多孔小球post-column derivatization 柱后衍生化potentiometer 电位计potentiometric titration 电位滴定法precipitation form 沉淀形式precision 精密度pre-column derivatization 柱前衍生化preparation 制剂prescription drug 处方药pretreatment 预处理primary standard 基准物质principal component analysis 主成分分析programmed temperature gas chromatography 程序升温气相色谱法prototype drug 原型药物provisions for new drug approval 新药审批办法purification 纯化purity 纯度pyrogen 热原pycnometric method 比重瓶法quality control(QC) 质量控制quality evaluation 质量评价quality standard 质量标准quantitative determination 定量测定quantitative analysis 定量分析quasi-molecular ion 准分子离子racemization 消旋化radioimmunoassay 放射免疫分析法random sampling 随机抽样rational use of drug 合理用药readily carbonizable substance 易炭化物reagent sprayer 试剂喷雾器recovery 回收率reference electrode 参比电极refractive index 折光指数related substance 有关物质relative density 相对密度relative intensity 相对强度repeatability 重复性replicate determination 平行测定reproducibility 重现性residual basic hydrolysis method 剩余碱水解法residual liquid junction potential 残余液接电位residual titration 剩余滴定residue on ignition 炽灼残渣resolution 分辨率,分离度response time 响应时间retention 保留reversed phase chromatography 反相色谱法reverse osmosis 反渗透rider peak 驼峰rinse 清洗,淋洗robustness 可靠性,稳定性routine analysis 常规分析round 修约(数字)ruggedness 耐用性safety 安全性Sakaguchi test 坂口试验salt bridge 盐桥salting out 盐析sample applicator 点样器sample application 点样sample on-line pretreatment 试样在线预处理sampling 取样saponification value 皂化值saturated calomel electrode(SCE) 饱和甘汞电极selectivity 选择性separatory funnel 分液漏斗shoulder peak 肩峰signal to noise ratio 信噪比significant difference 显著性差异significant figure 有效数字significant level 显著性水平significant testing 显著性检验silanophilic interaction 亲硅羟基作用silica gel 硅胶silver chloride electrode 氯化银电极similarity 相似性simultaneous equations method 解线性方程组法size exclusion chromatography(SEC) 空间排阻色谱法sodium dodecylsulfate, SDS 十二烷基硫酸钠sodium hexanesulfonate 己烷磺酸钠sodium taurocholate 牛璜胆酸钠sodium tetraphenylborate 四苯硼钠sodium thiosulphate 硫代硫酸钠solid-phase extraction 固相萃取solubility 溶解度solvent front 溶剂前沿solvophobic interaction 疏溶剂作用specific absorbance 吸收系数specification 规格specificity 专属性specific rotation 比旋度specific weight 比重spiked 加入标准的split injection 分流进样splitless injection 无分流进样spray reagent (平板色谱中的)显色剂spreader 铺板机stability 稳定性standard color solution 标准比色液standard deviation 标准差standardization 标定standard operating procedure(SOP) 标准操作规程standard substance 标准品stationary phase coating 固定相涂布starch indicator 淀粉指示剂statistical error 统计误差sterility test 无菌试验stirring bar 搅拌棒stock solution 储备液stoichiometric point 化学计量点storage 贮藏stray light 杂散光substituent 取代基substrate 底物sulfate 硫酸盐sulphated ash 硫酸盐灰分supercritical fluid chromatography(SFC) 超临界流体色谱法support 载体(担体)suspension 悬浊液swelling degree 膨胀度symmetry factor 对称因子syringe pump 注射泵systematic error 系统误差system model 系统模型system suitability 系统适用性tablet 片剂tailing factor 拖尾因子tailing peak 拖尾峰tailing-suppressing reagent 扫尾剂test of hypothesis 假设检验test solution(TS) 试液tetrazolium colorimetry 四氮唑比色法therapeutic drug monitoring(TDM) 治疗药物监测thermal analysis 热分析法thermal conductivity detector 热导检测器thermocouple detector 热电偶检测器thermogravimetric analysis(TGA) 热重分析法thermospray interface 热喷雾接口The United States Pharmacopoeia(USP) 美国药典The Pharmacopoeia of Japan(JP) 日本药局方thin layer chromatography(TLC) 薄层色谱法thiochrome reaction 硫色素反应three-dimensional chromatogram 三维色谱图thymol 百里酚(麝香草酚)(指示剂)thymolphthalein 百里酚酞(麝香草酚酞)(指示剂)thymolsulfonphthalein ( thymol blue) 百里酚蓝(麝香草酚蓝)(指示剂)titer, titre 滴定度time-resolved fluoroimmunoassay 时间分辨荧光免疫法titrant 滴定剂titration error 滴定误差titrimetric analysis 滴定分析法tolerance 容许限toluene distillation method 甲苯蒸馏法toluidine blue 甲苯胺蓝(指示剂)total ash 总灰分total quality control(TQC) 全面质量控制traditional drugs 传统药traditional Chinese medicine 中药transfer pipet 移液管turbidance 混浊turbidimetric assay 浊度测定法turbidimetry 比浊法turbidity 浊度ultracentrifugation 超速离心ultrasonic mixer 超生混合器ultraviolet irradiation 紫外线照射undue toxicity 异常毒性uniform design 均匀设计uniformity of dosage units 含量均匀度uniformity of volume 装量均匀性(装量差异)uniformity of weight 重量均匀性(片重差异)validity 可靠性variance 方差versus …对…,…与…的关系曲线viscosity 粘度volatile oil determination apparatus 挥发油测定器volatilization 挥发法volumetric analysis 容量分析volumetric solution(VS) 滴定液vortex mixer 涡旋混合器watch glass 表面皿wave length 波长wave number 波数weighing bottle 称量瓶weighing form 称量形式weights 砝码well-closed container 密闭容器xylene cyanol blue FF 二甲苯蓝FF(指示剂)xylenol orange 二甲酚橙(指示剂)zigzag scanning 锯齿扫描zone electrophoresis 区带电泳zwitterions 两性离子zymolysis 酶解作用。
USP401225药典的验证中英文对照

VALIDATION OF COMPENDIAL PROCEDURES药典方法的验证Test procedures for assessment of the quality levels of pharmaceutical articles are subject to various requirements. According to Section 501 of the Federal Food, Drug, and Cosmetic Act, assays and specifications in monographs of the United States Pharmacopeia and the National Formulary constitute legal standards. The Current Good Manufacturing Practice regulations [21 CFR 211.194(a)] require that test methods, which are used for assessing compliance of pharmaceutical articles with established specifications, must meet proper standards of accuracy and reliability. Also, according to these regulations [21 CFR 211.194(a)(2)], users of analytical methods described in USP NF are not required to validate the accuracy and reliability of these methods, but merely verify their suitability under actual conditions of use. Recognizing the legal status of USP and NF standards, it is essential, therefore, that proposals for adoption of new or revised compendial analytical procedures be supported by sufficient laboratory data to document their validity.用于评估药品质量的检验方法需要满足不同的要求。
configurational analysis 意思

configurational analysis 意思Configurational Analysis is an analytical framework used to examine the relationships between different elements or variables within a system or organization. It seeks to understand how these variables interact with each other and influence the overall performance or outcome. This article will delve into the concept of configurational analysis, its key components, and how it can be applied in various contexts.1. Introduction to Configurational Analysis:Configurational Analysis is based on the assumption that the configuration or arrangement of different elements in a system is crucial in determining the overall performance. It emphasizes the interdependencies and interactions between these elements, rather than focusing solely on individual variables. By examining the patterns and structures that emerge from these relationships, configurational analysis aims to uncover the underlying mechanisms or configurations that lead to specific outcomes.2. Key Components of Configurational Analysis:There are several key components of configurational analysis that need to be considered when conducting this type of analysis:2.1 Variables:Configurational analysis involves the identification and selection of relevant variables. These variables can be quantitative or qualitative in nature, and they should represent different aspects or dimensions of the system or organization under study. It is important to select variables that are meaningful and have a significant impact on the overall performance or outcome.2.2 Configurations:Configurations refer to the patterns or structures that emerge from the relationships between variables. These configurations can be simple or complex in nature, and they can take various forms, such as causal chains, feedback loops, or interaction effects. Configurations may involve both direct and indirect relationships between variables, and they can be represented graphically using causal maps or influence diagrams.2.3 Conditions:Conditions refer to the contextual factors or circumstances that shape the relationships between variables. These conditions can include external factors such as market conditions, regulatory environment, or technological advancements, as well as internal factors such as organizational culture, leadership style, or resource availability. Conditions can have a moderating or mediating effect on the relationships between variables and may influence the emergence of specific configurations.2.4 Outputs:Outputs refer to the desired or intended outcomes of the system or organization under study. These outputs can be tangible or intangible in nature, and they can be measured using various performance indicators or metrics. Outputs can include financial performance, customer satisfaction, employee engagement, or social impact, depending on the context or objectives of the analysis.3. Applying Configurational Analysis:Configurational analysis can be applied in various contexts, including business organizations, public institutions, social systems, or environmental systems. It can be used to understand the factors that contribute to success or failure, to identify critical leverage points or bottlenecks, or to design interventions or strategies for improvement.3.1 Business Organizations:In business organizations, configurational analysis can be used to understand the factors that drive profitability, market share, or customer loyalty. It can help identify the key resources, capabilities, or processes that contribute to competitive advantage and to design effective business models or strategies. Configurational analysis can also be used to analyze organizational culture, leadership style, or decision-making processes and to understand how these factors influence employee motivation, innovation, or performance.3.2 Public Institutions:In public institutions or government agencies, configurational analysis can be used to analyze the factors that contribute to effective policy implementation, service delivery, or citizen engagement. It can help identify the key drivers of public value and to design effective governance structures or accountability mechanisms. Configurational analysis can also be used to analyze the factors that contribute to the success or failure of public-private partnerships or collaborative networks.3.3 Social Systems:In social systems or communities, configurational analysis can beused to analyze the factors that contribute to social cohesion, social capital, or community resilience. It can help identify the key relationships, norms, or values that shape collective action or social change. Configurational analysis can also be used to analyze the factors that contribute to inequality, social exclusion, or conflict and to design interventions or policies for social justice or inclusion.3.4 Environmental Systems:In environmental systems or ecosystems, configurational analysis can be used to analyze the factors that contribute to ecological resilience, biodiversity, or sustainable resource management. It can help identify the key interactions, feedback loops, or thresholds that shape ecosystem dynamics or vulnerability. Configurational analysis can also be used to analyze the factors that contribute to environmental degradation, climate change, or natural disasters and to design interventions or policies for environmental sustainability or adaptation.4. Challenges and Limitations:4.1 Complexity:Configurational analysis involves dealing with complexity and uncertainty, as it seeks to understand and model the relationships between multiple variables and their configurations. This complexity can make it challenging to identify the most relevant variables or to determine the causal relationships between them. It often requires the use of advanced analytical methods, such as fuzzy set analysis or qualitative comparative analysis, to handle the complexity and uncertainty inherent in configurational analysis.4.2 Context-Specific:Configurational analysis is context-specific, meaning that the configurations and relationships identified in one context may not be applicable or transferable to other contexts. This context-specificity can limit the generalizability of findings and may require the replication or validation of results in different settings or conditions. It also makes it challenging to compare or aggregate configurational analysis across different studies or contexts.4.3 Data Availability:Configurational analysis relies on the availability of relevant and accurate data to identify and analyze the relationships between variables. However, data collection and analysis can be time-consuming and resource-intensive, especially when dealing with complex and dynamic systems. It may also be challenging to quantify or measure certain variables or to obtain reliable data for all relevant variables. These data limitations can affect the validity and reliability of configurational analysis findings.5. Conclusion:Configurational analysis is a powerful approach for understanding and analyzing complex systems or organizations. By examining the relationships between variables and their configurations, configurational analysis can provide valuable insights into the underlying mechanisms or configurations that lead to specific outcomes. However, configurational analysis also presents challenges in terms of complexity, context-specificity, and data availability. Despite these limitations, configurational analysis offers a unique and holistic perspective on the interdependenciesand interactions that shape the performance or outcomes of systems or organizations.。
药物分析专业英语
(dissolution) vessel 溶出杯(FTIR) 傅里叶变换红外光谱仪13C-NMR spectrum,13CNMR 碳-13核磁共振谱1ength basis 长度基准1H-NMR 氢谱2D-NMR 二维核磁共振谱:2D-NMR3D-spectrochromatogram 三维光谱-波谱图Aa stream of nitrogen 氮气流a wide temperature range 宽的温度范围absolute detector response 检测器绝对响应(值)absolute entropy 绝对熵absolute error 绝对误差absolute reaction rate theory 绝对反应速率理论absolute temperature scale 绝对温标absorbance 吸光度,而不是吸收率(absorptance)。
当我们忽略反射光强时,透射率(T)与吸光度(A)满足如下关系式:A=lg(1/T)。
absorbance noise, absorbing noise 吸光度噪音。
也称光谱的稳定性,是指在确定的波长范围内对样品进行多次扫描,得到光谱的均方差。
吸光度噪音是体现仪器稳定性的重要指标。
将样品信号强度与吸光度噪音相比可计算出信噪比。
absorbed water 吸附水absorptance 吸收率absorptant 吸收剂absorption band 吸收带absorption cell 吸收池absorption curve 吸收光谱曲线/光吸收曲线absorption tube 吸收管abundance 丰度。
即具有某质荷比离子的数量accelerated solvent extraction(ASE) 加速溶剂萃取accelerated testing 加速试验accelerating decomposition 加速破坏acceptance limit,acceptance criterion 验收限度,合格标准accidental error 随机误差accuracy 准确度。
Analytical Methods in Environmental Chemistry
Analytical Methods in EnvironmentalChemistryEnvironmental chemistry is a rapidly growing field of study that deals with the chemical and physical processes that occur in natural systems, including the air, water, and soil. Analytical methods play a critical role in environmental chemistry, providing researchers with the tools they need to understand and quantify the complex chemical interactions that are taking place in our environment. This article will discuss some of the analytical methods that are commonly used in environmental chemistry, and describe how they are applied to solve real-world environmental problems.The first analytical method that we will discuss is chromatography, which is a technique that separates mixtures into their individual components based on their physical and chemical properties. Chromatography is widely used in environmental chemistry to isolate and identify pollutants in air, water, and soil samples. Gas chromatography is often used to analyze air samples for volatile organic compounds (VOCs) and other pollutants, while liquid chromatography can be used to separate complex mixtures of organic compounds in water and soil samples. The use of chromatography in environmental chemistry has revolutionized the field, allowing researchers to accurately measure even trace amounts of pollutants in the environment.Another important analytical technique in environmental chemistry is spectrophotometry, which measures the interaction between light and matter. Spectrophotometry is commonly used to analyze heavy metals in water samples, as well as to measure the absorption of pollutants like carbon dioxide and ozone in the atmosphere. This technique can provide precise measurements of environmental contaminants, allowing researchers to track their sources, pathways, and impact on the environment.In addition to chromatography and spectrophotometry, environmental chemists also use a variety of other analytical methods, including mass spectrometry, electrochemistry,and atomic absorption spectroscopy. Mass spectrometry is especially useful for analyzing the complex mixtures of compounds found in environmental samples, while electrochemistry can be used to measure the properties of environmental pollutants like soil pH and redox potential. Atomic absorption spectroscopy is another important technique in environmental chemistry that is used to analyze the concentration of heavy metals in water and soil samples.While each of these analytical methods has its own advantages and limitations, it is often necessary to use a combination of techniques to fully analyze an environmental sample. For example, a researcher studying the impact of industrial activities on a local waterway might use a combination of gas chromatography, spectrophotometry, and atomic absorption spectroscopy to identify and quantify the various pollutants present in the water. By analyzing the results of these different tests together, the researcher can get a more complete picture of the chemical interactions taking place in the environment.In conclusion, analytical methods are a critical component of environmental chemistry and provide researchers with the tools they need to understand and quantify the complex chemical interactions that take place in the environment. Chromatography, spectrophotometry, mass spectrometry, electrochemistry, and atomic absorption spectroscopy are just a few of the techniques commonly used in this field. By using a combination of these techniques, environmental chemists can gain a deeper understanding of the causes and impacts of environmental pollution, and develop effective strategies for mitigating its effects on our planet.。
201507FDA行业指南:分析方法验证(中英文)(中)
201507FDA行业指南:分析方法验证(中英文)(中)A. Principle/Scope 原理/范围A description of the basic principles of the analytical test/technology (i.e., separation, detection); target analyte(s) and sample(s) type (e.g., drug substance, drug product, impurities or compounds in biological fluids).分析测试/技术(即分离、检测)基本原因的描述;目标分析物和样品类型(例如,原料药、制剂、杂质或生物流体中的化合物)。
B. Apparatus/Equipment 仪器/设备All required qualified equipment and components (e.g., instrument type, detector, column type, dimensions, and alternative column, filter type).所有需要的确认过的仪器和组件(例如,仪器类型、检测器、柱子类型、尺寸和可替代的柱子、过滤器类型)。
C. Operating Parameters 运行参数Qualified optimal settings and ranges (include allowed adjustments supported by compendial sources or development and/or validation studies) critical to the analysis (e.g., flow rate, components temperatures, run time, detector settings, gradient, head space sampler). A drawing with experimental configuration and integration parameters may be used, as applicable.确认过的优化的设置和范围(包括来自药典或研发和/或验证研究的允许调整),对于分析过程非常关键(例如,流速、部件温度、运行时间、检测器设置、梯度、顶空进样器)。
药物分析常用英语词汇
药物分析专业英语词汇表Aabsorbance吸收度absorbanceratio吸收度比值absorption吸收absorptioncurve吸收曲线absorptioncoefficient吸收系数accuratevalue准确值Acid—dyecolormcty酸性染料比色法acidimcty酸量法acidity酸度activity活度adjustedretentiontime调整保留时间absorbent吸收剂absorption吸附alkalinity碱度alumina氧化铝,矾土ambienttemperature室温ammoniumthiocyanate硫氰酸铵analyticalqualitycontrol分析质量控制anhydroussubstance 干燥品antioxidant抗氧剂applicationofsample点样areanormalizationmethod面积归一法arsenic砷arsenicsport砷斑assay含量测定assaytolerance含量限度attenuation衰减acidburette酸式滴定管alkaliburette碱式滴定管amortar研钵Bbackextraction反萃取bandabsorption谱带吸收batch批batchnumber批号Benttendorlfmethod白田道夫法betweendayprecision日间密度精biotransformation生物转化blanktest空白试验boilingrange沸程BritishPharmacopeia英国药典bromatetitration溴酸盐滴定法brominemethod溴量法bromothymolblue溴麝香酚蓝bulkdrug原料药by—product副产物breaker烧杯buretteglassbeadnozzle滴定管brownacidburette棕色酸式滴定管Ccalibrationcurve校正曲线calomelelectrode甘汞电极calorimetry量热分析capacityfactor容量因子capillarygaschromatography毛细管气相色谱法carriergas载气characteristicsdescription性状chelatecompound螯合物chemicalequivalent化学当量Chinesepharmacopeia中国药典Chinesematerialmedicine中成药Chinesematerialmidicalpreparation中药制剂chiral手性的chiralcarbonatom手性碳原子chromatogram色谱图chromatography色谱法chromatographiccolumn色谱柱chromatographiccondition色谱条件clarity澄清度coefficientofdistribution分配系数coefficientofvariation变异系数colorchangeinterval变色范围colorreaction显色反应colormetry比色法columnefficiency柱效columntemperature柱温comparativetest比较试验completenessofsolution溶液的澄清度conjugate缀合物concentration—timecurve浓度时间曲线confidenceinterval置信区间confidencelevel置信水平controlledtrial对照试验correlationcoefficient相关系数contrasttest对照试验congealingpoint凝点contentunifarmity装量差异controlledtrial对照试验correlationcoefficient相关系数contrasttest对照试验counterion反离子cresalred甲酚红cuvettecell比色池cyanide氰化物casserolesmall勺皿Ddead—stoptitration永定滴定法deadtime死时间deflection偏差deflectionpoint拐点degassing脱气deionizedwater去离子水deliquescence潮解depressorsubstancestest降压物质检查法desiccant干燥剂detection检查developingreagent展开剂developingchamber展开室deviation偏差dextrose右旋糖diastereoisomer非对映异构体diazotization重氮化differentialthermalanalysis差示热分析法differentialscanningcalorimetry差示扫描热法Gutzeit古蔡daytodayprecision日间精密度dissolution溶出度directinjection直接进样2,6-dichlorindophenoltitration2,6-二氯靛酚滴定法digestion消化diphastictitration双向滴定disintegrationtest崩解试验dispersion分散度dissolubility溶解度dissolutiontest溶解度检查distillingrange滴程distributionchromatography分配色谱dose剂量drugqualitycontrol药品质量控制dryingtoconstantweight干燥至恒重duplicatetest重复试验diskmethodwatermethod压片法Eeffectiveconstituent有效成分effectiveplatenumber有效板数effectiveofcolumn柱效electrophoresis电泳elimination消除eluate洗脱液elution洗脱enamtiomer对映体endabsorption末端吸收endogenoussubstances内源性物质enzymedrug酶类药物enzymeinduction酶诱导enzymeinhibition酶抑制epimer差向异构体equilibriumconstant平衡常数errorinvolumetricanalysis容量分析误差exclusionchromatography排阻色谱法expirationdate失效期externalstandardmethod外标法extract提取物extrationgravimetry提取重量法extractiontitration提取容量法extrapolatedmethod外插法Erlenmeyerflask锥形瓶evaporatingdishsmall蒸发皿elongatedbulb胖肚electronicbalanceMettlerAL204MettlerAL204电子天平Ffactor系数fehling’sreaction斐林实验filter过滤finenessoftheparticles颗粒细度flowrate流速fluorescentagent荧光剂fluorescencespectrophotometry荧光分光光度法fluorescencedetection荧光检测器fluorescenceanalysis荧光分析法foreignpigment有色杂质formulary处方集free游离freezingtest冻结试验fusedsilica熔融石英filterpaper滤纸Ggaschromatography气相色谱法gas-liquidchromatography气液色谱法gaspurifier气体净化器Generalidentificationtest一般鉴别试验generalnotices凡例Generalrequirements(药典)通则goodclinicalpractices药品临床管理规范goodlaboratorypractices药品实验室管理规范goodmanufacturingpractices(GMP)药品生产质量管理规范goodsupplypractices(GSP)药品供应管理规范gradientelution梯度洗脱grating光栅gravimetricmethod重量法Gutzeittest古蔡(检砷)法glassfunnellongstem玻璃漏斗gradcylinder量筒glassrod玻棒graduatedpipettes刻度吸管GC气相色谱Hheavymetal重金属halfpeakwidth平峰宽heatconductivity热导率heightequivalenttoatheoreticalplate理论塔板高度heightofaneffectiveplate有效塔板高度high-performanceliquidchromatography(HPLC)高效液相色谱法high-performancethin-layerchromatography(HPTLC)高效薄层色谱法hydrate水合物hydrolysis水解hydrophilicity亲水性hydrophobicity疏水性hydroxylvalue羟值hyperchromiceffect浓色效应hypochromiceffect淡色效应HHS-typeconstanttemperaturewaterbathHHS型恒温水锅HPLC高效液相色谱法Iidentification鉴别ignitiontoconstantweight灼烧至恒重immobilephase固定相immunoassay免疫测定impurity杂质inactivation失活index索引indicatorelectrode指示电极indicator指示剂inhibitor抑制剂injectingseptum进样隔膜胶垫instrumentalanalysis仪器分析injectionvalue进样阀insulinassay胰岛素生物检测法integrator积分仪intercept截距interface接口internalstandardsubstance内标物质Internationalunit国际单位invitro体外invivo体内iodide碘化物iodoformreation碘仿反应iodometry碘量法ionpairchromatography离子对色谱ionsuppression离子抑制ionsuppression离子抑制ionicstrength离子强度ion-pairingagent离子对试剂ionization电离isoabsorptivepoint等吸收点isocraticelution等溶剂组成洗脱isoelectricpoint等电点isoosmoticsolution等渗溶液irreversibleindicator不可逆指示剂irreversiblepotential不可逆电位KKarlFischertitration卡尔-费舍尔滴定Kjeldahlmethodfornitrogen凯氏定氮法Koberreagent 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a r X i v :q u a n t -p h /0511230v 1 24 N o v 2005Analytical regularisation for confined quantum fields betweenparallel surfacesF C Santos ∗,A C Tort †Departamento de F´ısica Te´o rica -Instituto de F´ısicaUniversidade Federal do Rio de JaneiroCaixa Postal 68.528;CEP 21941-972Rio de Janeiro,Braziland E Elizalde ‡Instituto de Ciencias del Espacio (CSIC)&Institut d’Estudis Espacials de Catalunya (IEEC/CSIC)Campus UAB,Facultat de Ci`e ncies,Torre C5-Parell-2a plantaE-08193Bellaterra (Barcelona)SpainFebruary 9,2008AbstractWe review a simple technique for evaluating the vacuum energy stemming from non-trivial boundary con-ditions and present results for the Casimir energy of a massive fermionic field confined in a d +1-dimensional slab-bag and the effect of a uniform magnetic field on the vacuum energy of confined massive bosonic and fermionic fields.New results concerning the Casimir energy and the evaluation of the rate of creation of quanta in κ-deformed theories are presented.PACS:11.10.-z;12.20.-m;12.39.Ba1IntroductionIn quantum field theory under external conditions,the macroscopically observable zero-point energy shift is de-fined as the regularised difference between the vacuum expectation value of the hamiltonian with and without the presence of the external conditions.Under certain assumptions,external conditions can be approximated by boundary conditions and one-loop calculations of the energy shift lead to the Casimir effect [1]–see Ref.[2]for the most recent review on this subject.In the evaluation of the zero point energies some configurations which depend on the nature of the particular quantum field (scalar,spinorial,etc.),the type of spacetime manifold and its dimensionality,and the specific boundary condition imposed on the quantum field on certain surfaces,may lead to rather complex spectra.The heart of the matter in these calculations is the evaluation of the spectral sum that results at the one-loop level from the shift of the zero-point energy.This evaluation requires regularisation andrenormalisation,and recipes for accomplishing this task range from the relatively simple cutoff method,employed by Casimir himself [1],to a number of powerful and generalised zeta function techniques [3].Contour integral rep-resentations of spectral sums are a great improvement in the techniques of evaluating zero-point energies and have been employed before [4].A simple technique for evaluating vacuum energy stemming from non-trivial boundary conditions based on Cauchy’s integral formula and the Mittag-Leffler expansion theorem was proposed in [5,6].The method was employed in a number of cases,in particular it was applied to calculate the Casimir energy of a massive fermionic field confined in a d +1-dimensional slab-bag [6]and to calculate the effect of a uniform magnetic field on the vacuum energy of confined massive bosonic and fermionic fields [7].Recently this technique was applied to evaluate the Casimir energy of κ-deformed theories under Dirichlet boundary onditions [8].Here we review these cases and extend the method to the evaluation of the rate of creation of quanta in κ-deformed theories.2A general formula for the regularised vacuum energy shiftFor a field theory in d +1flat spacetime under boundary conditions imposed on two parallel planes of area equal to L d −1which are kept at a fixed distance ℓfrom each other,and with L ≫ℓ,the non-regularised vacuum energy is given byE 0(d )=α(d )L d −1(2π)d −1Ωn(1)where α(d )is a dimensionless factor that takes into account the internal degrees of freedom andΩn =ℓ+m 2(2)with p 2⊥=p 21+p 22+p 23+···+p 2d −1and m is the mass of an elementary excitation of the field and the λn are the real roots of the equation determined by the boundary conditions.Consider nownΩn =− Γdqq 2+Ω2n (3)which follows from Cauchy’s integral formula.The curve Γis a Jordan curve on the complex q -plane with Im q >0that we choose to be a semicircle with very large radius the diameter of which is the entire real axis of the auxiliary variable q .Defining z =ℓ2πℓ2q 2z 2+λ2n(5)This summation can be performed in the following way:Let G (z )be a complex function of the complex variable z symmetrical on the real axis and suppose its roots λn are simple,nonzero and symmetrical with respect to the origen.Notice that if z =0is a root of G we can divide G by some suitable power eliminating this root from the set of roots without introducing new singularities.Since the roots are symmetrical we can order them in such a way that λn =−λ−n with n =±1,±2,....Defining the auxiliary function J (z )byJ (z )=′n1where the prime indicates the the term n=0is to be omitted.This function is meromorphic with simple poles at iλn and residua equal to one.Defining the function K(z)=G(iz)we see that the function K′(z)/K(z)has simple poles at z=iλn with residua also equal to one.Due to the symmetry of the roots we can writeJ(z)=K′(z)K(z)= 2z2 d d−1p⊥2πq d ln[K(z)]2 d d−1p⊥2πln[K(z)](9)At this point it is possible to simplify this last expression by decomposing the function K(z)into two parts, namely K(z)=K1(z)+K2(z)where K1(z)contains all terms whose integrals diverge when Re>0and K2(z)contains all terms whose integrals diverge when Re<0;also K1(z)=K2(−z).In this way the integral in equation(9)can be written asI= Γ1dq2πln 1+K2(z)2πln[K1(z)]+ Γ2dq K2(z) (10) The regularised vacuum energy shift is thenE0(z)=α(d)L d−1(2π)dln 1+K1(z)p2+m2with p:=x/ℓand integrating out the angular part we obtainE0(ℓ,µ,d)=α(d)L d−1K2(z) (12)All along the real axis the function z does not changes its sign and is a function of q and p⊥.This approach to the evaluation of the Casimir energy can be also applied when the integrand is a more complex function ofΩn.It is convienient to make the replacement z→ω=2dπd/2Γ d2−1ln1+K1(ω)3Quantumfields confined between parallel surfacesEquation(12)is a general formula that can be applied to all cases of quantumfields confined between two parallel surfaces on which we impose boundary conditions.A non-trivial example is the one of the Casimir energy for a massive fermionicfield confined in a d+1-dimensional slab-bag under MIT boundary conditions[9],[6].If the surface of the bag is perpendicular to the d-direction MIT boundary cconditions lead to the functionF(p dℓ)=µsin(p dℓ)+p dℓcos(p dℓ)(14) Hence we can choose G(ω)asG(ω)=µsin(ω)ω+cosh(ω)(16)It follows thatK1(ω)=1ω e−ω(17)andK2(ω)=1ω eω(18)The regularised Casimir energy of the fermionfield isE0(ℓ,µ,d)=−C(d)L d−12 ℓd ∞µdωω ω2−µ2 dω+µe−2ω (19)Setting d=3we obtain the the result given in[10].We can explore this result and lengthy calculation shows that upon expanding the log function we end up with a convergent sum of integrals that can be expressed each one of them as a derivative of the Whittaker function Wνµwith respect to an auxiliary variableλatλ=1.This is as far as we can go analytically.But it is possible to consider and obtain analytical results in the massless limit and the very massive limit,see[6]for details.4Confined bosonic and fermionicfields in a uniform magneticfieldThe analytical regularisation scheme can be also applied to massive bosonic and fermionicfields in a uniform magneticfield perpendicular to the confining surfaces.Let us considerfirst the case of a charged scalarfield under Dirichlet boundary conditions.In this case we will haveE0(ℓ,µ,eB)=α eB2∞ n=0∞ 0dp3ℓ2p23+eBℓ2(2n+1)+µ2(22)4whereµ:=mℓ.The integrand can be expanded and the Casimir energy can be expressed as a convergent infinite series of integrals that can be evaluated in terms of the Whittaker functions.Thefinal result readsE0(ℓ,µ,eB)=−eBL2eBℓ2+µ2∞k=11eBℓ2+µ2−eBL2(2n+1)eBℓ2+µ2∞k=11(2n+1)eBℓ2+µ2 (23)Notice that this is an exact result.If eB≫ℓ2the behavior of the Bessel function of the third kind leads us to writeE0(ℓ,eB)π1/2ℓ3e−2√2 eBL22πln 1−z−µℓ2p23+(2n+1−α)eBℓ2+µ2n=0,1,2,3, (27)after expanding the log and summing overαwe arrive atE0(ℓ,µ,eB)=−2eBL2kI pk(M p)(28)where the prime means that the term corresponding to p=−1must be multiplied by1/2andI pk(M p):=∞dx x2+M2p 1/2+µ −k x2+M2p 1/2−µ k e−2k(x2+M2p)1/2(29)with x=p3ℓand M2p:=2(p+1)eBℓ2+µ2for p=−1,0,1,2,3,···.These integrals are non-trivial ones but a numerical evaluation of equation(28)is feasible[7].Two limiting cases,however can be solved analytically.The first one is limitµ→0and the other one is the limitµ≫1.For the massless limit we obtainE0(ℓ,µ→0,eB)≈−eBL232π3/2ℓe−2µ5Vacuum energy shift inκ-deformed theoryA quantumfield theory isκ-deformed when its spacetime symmetries are described by theκ-deformed Poincar´e algebra.These theories which may be important in some models of the early universe lead in general to highly nontrivial dispersion relations.See[12]and references therein.Consider for example scalarκ-deformed electro-dynamics.The frequency spectrum is given byω(p)=sinh−1 1p2+m2 (32)The parameterκis a measure of the departure from the Poincar´e algebra.For Dirichlet boundary coditions imposed on a certain direction,part of the frequency sepectrum is discretised and the vacuum energy shift is given byE0(ℓ,η,m)=L2 n d2p⊥ηsinh−1(ηΩn)(33) where asΩn=2π n2q2n d2p⊥(2π)31/ηdq1−η2q2log 1+K1(z)(2π)21/ηdq1−η2q2I q2 (37)where4ℓ2 q2+m2 ℓq2−Li2 e−2ℓ√q2+m2 ℓq2− q2+m2 (38) Forη→0and m→0we obtain the standard Casimir energy of a massless scalarfield under Dirichlet boundary conditions,Forη=0and m=0we obtainE0(ℓ,η,m=0)=−L2n2 1/η0dy1+1n2y2ℓ2(39)in agreement with[12].66Photon creation rate for κ-deformed theoryIn a κ-deformed theory there is the possibility of quanta creation.The rate at which photons are created is related to the quantityS =iη2πd 2p ⊥ηsinh−1ηp 2⊥+p 2n=−ndqq 2+Ω2n (42)then the photon creation rate can be rewritten asS =−L 2q 2+Ω2nsin −1(ηq )24π3d 2p ⊥∞1/ηdqdq 1−η2q 2log1+K 1(z )4π3d 2p ⊥∞1/ηdq η2q 2−1log1−e−2ℓ√4π2ℓ3∞ n =11ℓ2−11+1References[1]Casimir H B G1948Proc.K.Ned.Akad.Wet.51793[2]Bordag M,Mohideen U and Mostepanenko V M2001Phys.Rept.3531;see also:Plunien G,Muller Band Greiner W1986Phys.Rep.13487;Mostepanenko V and Trunov N N1997The Casimir effect and its Applications,(Clarendon Press,Oxford)[3]Elizalde E,Odintsov S D,Romeo A,Bytsenko A A and Zerbini S1994Zeta function regularization tech-niques with applications,(World Scientific,Singapore);Elizalde E1995Ten Physical Applications of Spec-tral Zeta Functions(Springer-Verlag,Berlin)[4]Bordag M,Elizalde E and Kirsten K1996J.of Math.Phys37895;Bordag M,Elizalde E,Geyer B andKirsten K1996Comm.Math.Phys.179215;Bordag M,Elizalde E,Kirsten K and Leseduarte S1997Phys.Rev.D564896;Bordag M,Elizalde E and Kirsten K1998J.of Phys.A:Math.Gen.311743[5]Santos F C and Tort A C The Casimir energy of a massive fermionfield revisited,quant-ph/0201104.[6]Elizalde E,Santos F C and Tort A C2003Int.J.Mod.Phys A181761-1772[7]Elizalde E,Santos F C and Tort A C2002J.of Phys A:Math.Gen.357403-7414[8]Elizalde E,Palma D,Santos F C and Tort A C2005Proc.Sci.WC2004030[9]Johnson K1975Acta Phys.Polonica 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