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suzuki反应

Suzuki偶联反应
报告人：王辉 2011.10.15
内容简介
1. 前言
2. Suzuki反应的影响因素
3. Suzuki偶联反应的研究进展
4. Suzuki反应的应用
5. 结论和展望
6. 谢谢
1. 前言
1.1 引言在过渡金属催化的芳基偶联反应中，Suzuki等人1981年开发的在Pd(PPh3)4催化下，芳基硼酸与溴或碘代芳烃的交叉偶联反应被称为Suzuki芳基偶联反应。该反应因具有反应条件温和、可容忍多种活性官能团、受空间位阻影响不大、产率高以及芳基硼酸经济易得且对潮气不敏感等优越性而成为普遍适用的C’一 C, 键偶联方法，倍受有机及高分子合成工作者的青睐。
2.3.2.1 有关Ni催化剂的一些报道
1. 1995年，Percec等报道了以1,1’-二（二苯基膦）二茂铁（dppf）为配体的Ni催化剂NiCl2(dppf)/Zn可以催化各种磺酸芳基酯与苯硼酸的Suzuki反应，在相同情况下，Ni催化剂的效果明显好于Pd催化剂。
2. 1996年，Saito等首次报道了NiCl2 (dppf)/BuLi可以有效催化氯代芳烃参与的Suzuki反应，并且催化效果很好。
3. Suzuki偶联反应的研究进展（配体的发展）
3.1 催化氯代芳烃的Suzuki偶联反应
Fu等合成了二茂铁衍生物膦配体1、2、3、4对氯代芳烃均表现了很好的催化活性。
Verkade等合成一系列具有非常大空间位阻的双环笼状配体5具有高催化活性。 Capretta等合成了类金刚烷式配体6对芳环上有吸电子和给电子基团均表现出非常好的催化活性。 Hreemann等合成了卡宾配体7对氯甲苯与苯硼酸催化效果较好。早些时候Nolan等报道了咪唑盐8在反应中原位生成卡宾，极大的提高了Pd2（dba）3的催化活性。

称之为Suzuki偶联反应

分子间Heck反应
决定烯烃活性的主要因素是烯烃双键碳原子取代基的大小和数目。一般情况下，取代基越大，数目越多，反应速度越小，收率越低。
在大多数情况下，Pd-H的消除符合Curtin-Hammett动力学控制规则，即过渡态的能量反应了顺反异构体的比例。一般情况下，除非R特别小（如 –CN）,反式异构体是主要产物，（见下例）。其选择性甚至超过Wittig-Horner反应。但由于存在异构化，热力学控制时常常产生二者的混合物，从而导致例外的情况出现。
Heck, Ei-ichi Negishi, Akira Suzuki
贡献：
瑞典皇家科学院在颁奖词中说，借助工具手册上的赫克反应、根岸反应和铃木反应，化学家们合成出海绵，根岸反应则是这个合成中的中心步骤。其他的科学家优化了这个过程，获得足够量的海绵，开始了对人类癌症治疗的临床试验。
赫克反应是创建碳原子间单键链接的最重要方法之一，被用于止痛药萘普生（naproxen）、哮喘药孟鲁司特等的大规模生产。
1. 溶剂：在极性溶剂里此偶联反应的产率可以得到很大的提高： DMSO≥ DMF > dioxane > toluene。 2. 碱：经过验证，KOAc是应用于这个反应最合适的碱，其他的如 K3PO4或K2CO3这些碱性略强的碱会进一步使原料芳基卤发生自偶联反应的结果。 3. 催化剂：对于制备溴代物和碘代物相应的芳基硼酸酯， Pd(dppf)Cl2一般可以得到很好的结果，又由于其具有易于反应的后处理的优点，因此是公司目前最常用的一类催化剂。 4. 对于氯代物，2001年Ishiyama经过研究发现在 Pd(dba)2/2.4PCy3(3-6mol %) 的催化下此类反应可以接近定量的进行
分子间Heck反应

离子液体在Suzuki偶联反应中的应用

2013 年第 35 卷第 6 期
化学与黏合 CHEMISTRY AND ADHESION
· ５５ ·
构。反应结束后，仅通过乙酸乙酯萃取，即可实现产物与反应体系的分离。
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Ｚｈａｏ等［１６］制备出一系列的氰基配位功能化的吡啶型离子液体钯催化剂１３，这些催化剂可催化碘代芳基与芳基硼酸的Ｓｕｚｕｋｉ偶联反应，反应收率在８０％以上。实验结果表明，催化剂ｃ在［Ｃ３ＣＮｐｙ］［Ｔｆ２Ｎ］作为溶剂时，重复使用９次，反应活性依然没有降低。
2013 年第 35 卷第 6 期
化学与黏合 CHEMISTRY AND ADHESION
· ５３ ·
离子液体在 Suzuki 偶联反应中的应用 *
李鹏宇２，李猛１，白雪峰１，２＊＊
（１．黑龙江省科学院石油化学研究院，黑龙江哈尔滨１５００４０；２．黑龙江大学化学化工与材料学院，黑龙江哈尔滨１５００８０）
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Ｓｏｎｇ等［１３］使用［Ｅｍｉｍ］［ＴＦ２Ｎ］离子液体作为溶剂，以３ｍｏｌ％芳基咪唑１０为前催化剂，加入氯化钯，水为溶剂，１００℃下进行Ｓｕｚｕｋｉ反应，溴苯与苯硼酸收率达８８％。反应中也观察到了纳米粒子钯的存在。

常见化学品CAS号列表

常见化学品CAS号列表CAS 中文名称英文名称MF51762-67-5 3-硝基邻苯二腈3-Nitrophthalonitrile C8H3N3O25446-18-4 2,4-二氯苯肼盐酸盐2,4-Dichlorophenylhydrazine hydrochloride C6H7Cl3N247250-53-3 2,2-BIS(3-AMINOPHENYL)HEXAFLUOROPROPANEC15H12F6N22380-78-1 4-羟基-3-甲氧基苯乙醇Homovanillyl alcohol C9H12O31712-70-5 对氯甲基苯乙烯4-Chloro-alpha-methylstyrene C9H9Cl935-30-8 2-氮杂环壬酮2-AZACYCLONONANONE C8H15NO3012-65-5 柠檬酸氢二铵Ammonium citrate dibasic C6H14N2O71912-28-3 2-(N-吗啉）乙烷磺酸MES C6H13NO4S91-10-1 2,6-二甲氧基苯酚2,6-Dimethoxyphenol C8H10O3261944-56-3 5-氨基-2,4-二氟三氟甲苯5-AMINO-2,4-DIFLUOROBENZOTRIFLUORIDE C7H4F5N2415-85-2 4'-甲基乙酰乙酰苯胺N-(4-Methylphenyl)-3-oxobutanamideC11H13NO2460-43-5 2,2,2-三氟乙基甲基醚2,2,2-TRIFLUOROETHYL METHYL ETHER C3H5F3O10101-53-8 硫酸铬Chromic sulfate Cr2O12S36850-28-8 三羟甲基氨基甲烷醋酸盐Tris(hydroxymethyl)aminomethane acetate salt C16H31N3O131120-01-0 正十六烷基硫酸钠N-HEXADECYLSULFURIC ACID SODIUM SALT C16H33NaO4S112809-25-3 4-(1H-1,2,4-三唑-1-基甲基)苯甲腈4-(1H-1,2,4-Triazol-1-ylmethyl)benzonitrile C10H8N4592-85-8 硫氰酸汞(II) MERCURIC THIOCYANATE C2HgN2S2223463-13-6 5-溴-2-碘吡啶5-Bromo-2-iodopyridine C5H3BrIN4343-75-3 4-AMINO-4H-1,2,4-TRIAZOLE-3-THIOL C2H4N4S14794-31-1 丁二酸单乙酯酰氯Ethyl 3-(chloroformyl)propionateC6H9ClO3726-25-0 1-BENZYL-3-PHENYL-2-THIOUREA C14H14N2S207974-20-7 3-氟-5-(三氟甲基)苯丙酮3'-FLUORO-5'-(TRIFLUOROMETHYL)PROPIOPHENONE C10H8F4O 1314-41-6 四氧化三铅Lead oxide OPb36725-28-7 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone C11H13N3O 74938-88-8 (4-脒苯基)甲磺酰氟盐酸盐4-Amidinophenylmethanesulfonyl fluoride hydrochloride C8H10ClFN2O2S94-67-7 水杨醛肟Salicylaldoxime C7H7NO256860-82-3 1,1,2,3,3,3-HEXAFLUOROPROPYL DICHLOROMETHYL ETHER C4H2Cl2F6O90090-64-5 2-(噻吩-2-基)吡咯烷2-(Thien-2-yl)pyrrolidine C8H11NS621-42-1 N-(3-羟基苯基)乙酰胺3-ACETAMIDOPHENOL C8H9NO2554-07-4 氰金(I)酸钾POTASSIUM DICYANOAURATE(I) C2AuKN2 34312-77-1 反式-2-(2-硝基乙烯基)噻吩(E)-2-(2-Nitroethenyl)thiopheneC6H5NO2S117391-52-3 3-氨基-3-(4-乙基苯基)丙酸3-AMINO-3-(4-ETHYLPHENYL)PROPANOIC ACID C11H15NO224631-29-6 N,N-二甲基对苯二胺草酸盐N,N-DIMETHYL-1,4-PHENYLENEDIAMINE OXALATE C10H14N2O4 33898-90-7 2-噻吩基乙酰腈2-THENOYLACETONITRILE C7H5NOS 101-94-0 苯乙酸对甲酚酯p-Tolyl phenylacetate C15H14O294461-44-6 2,4-二甲基吡咯-3,5-二羧酸二叔丁酯Di-(tert-butyl)3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate C16H25NO45378-49-4 5-氨基四氮唑5-AMINO-1H-TETRAZOLE CH3N598-52-2 4-叔丁基环己醇4-tert-Butylcyclohexanol C10H20O59-88-1 盐酸苯肼Phenylhydrazine hydrochloride C6H9ClN210378-47-9 硫酸铈铵AMMONIUM CERIUM(IV) SULFATE DIHYDRATE CeH20N4O18S419099-93-5 1-Cbz-4-哌啶酮1-Cbz-4-Piperidone C13H15NO315045-43-9 2,2,5,5-四甲基四氢呋喃2,2,5,5-TETRAMETHYLTETRAHYDROFURAN C8H16O635-21-2 2-氨基-5-氯苯甲酸2-Amino-5-chlorobenzoic acid C7H6ClNO2 56-69-9 5-羟基色氨酸5-Hydroxytryptophan C11H12N2O3538-28-3 S-苄基硫脲盐酸盐2-Benzyl-2-thiopseudourea hydrochlorideC8H11ClN2S623-17-6 乙酸糠酯Furfuryl acetate C7H8O352709-83-8 4'-正丁基-4-氰基联苯4'-Butyl-4-biphenylcarbonitrileC17H17N618-80-4 2,6-二氯-4-硝基苯酚2,6-Dichloro-4-nitrophenol C6H3Cl2NO3 811-98-3 氘代甲醇METHANOL-D4 CD4O18511-62-1 (±)-4-氟苯乙烯环氧化物,98%2-(4-FLUOROPHENYL)OXIRANE C8H7FO96989-50-3 二吡啶硫碳酸酯DI-2-PYRIDYL THIONOCARBONATEC11H8N2O2S74-39-5 偶氧紫4-(4-NITROPHENYLAZO)RESORCINOL C12H9N3O4 156-41-2 4-氯苯乙胺4-Chlorophenethylamine C8H10ClN446-09-3 2-溴-5-氟硝基苯1-BROMO-4-FLUORO-2-NITROBENZENEC6H3BrFNO2113028-17-4 6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯Ethyl6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-car boxylate C18H20FN3O3S693-16-3 2-辛胺2-AMINOOCTANE C8H19N93-48-1 2,5-二甲基苄胺2,5-Dimethylbenzylamine C9H13N19604-05-8 磷酸肌酸酐二钠盐Disodium(1-methyl-4-oxoimidazolidin-2-ylidene)phosphoramidate C4H6N3Na2O4P 1693-86-3 3-己基噻吩3-Hexylthiophene C10H16S128-97-2 1,4,5,8-萘四甲酸1,4,5,8-Naphthalenetetracarboxylic acidC14H8O827465-51-6 对乙基苯丙酮4'-Ethylpropiophenone C11H14O97165-77-0 3,5-二溴苄腈3,5-DIBROMOBENZONITRILE C7H3Br2N 383127-25-1 2-(呋喃-3-基)吡咯烷2-Furan-3-ylpyrrolidine C8H11NO 86375-28-2 3-(TERT-OCTYLAMINO)PROPIONITRILE C11H22N22615-11-4 4-ACETYLPHENYL ETHER C16H14O37464-14-4 2-羟基-5-甲基-3-硝基吡啶2-Hydroxy-5-methyl-3-nitropyridineC6H6N2O3175278-33-8 2-二氟甲氧基溴苯2-(DIFLUOROMETHOXY)BROMOBENZENE C7H5BrF2O54773-19-2 2,3-二氯三氟甲苯2,3-Dichlorobenzotrifluoride C7H3Cl2F3 14464-32-5 N-羟基琥珀酰亚胺硬酯酸酯Stearic acid-N-hydroxysuccinimide ester C22H39NO4163702-05-4 ETHYL NONAFLUOROBUTYL ETHER C6H5F9O1083-30-3 ω-苄基苯乙酮BETA-PHENYLPROPIOPHENONE C15H14O 6131-99-3 二甲砷酸钠三水合物Sodium cacodylate trihydrateC2H12AsNaO5141774-61-0 2-(叔丁氧羰基氨基甲基)-哌啶2-(Boc-aminomethyl)-piperidine C11H22N2O2754-96-1 十六氟-1，10-癸二醇1H,1H,10H,10H-PERFLUORO-1,10-DECANEDIOL C10H6F16O2132664-85-8 2-氨甲基-5-甲基吡嗪2-(AMINOMETHYL)-5-METHYLPYRAZINE C6H9N3458532-84-8 2-氯吡啶-4-硼酸频哪醇酯2-Chloropyridine-4-boronic acid pinacol ester C11H17BClNO361830-21-5 2-氨基-5-溴噻唑-4-甲酸乙酯Ethyl2-amino-5-bromothiazole-4-carboxylate C6H7BrN2O2S41085-43-2 2-溴-3-硝基甲苯2-Bromo-3-nitrotoluene C7H6BrNO289-69-0 2,4,5-三氯硝基苯1,2,4-Trichloro-5-nitrobenzene C6H2Cl3NO2 2657-87-6 3,4'-二氨基二苯醚3,4'-Oxydianiline C12H12N2O20289-44-5 4-氨基吡唑嘧啶4-AMINOPYRAZOLO[3,4-D]PYRIMIDINEC5H5N5381233-96-1 2-氨基-3-碘-5-溴吡啶2-AMINO-5-BROMO-3-IODOPYRIDINE C5H4BrIN2127733-40-8 (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL C10H10ClF6N26750-81-2 阿利苯多Alibendol C13H17NO42396-65-8 1,8-壬二炔1,8-NONADIYNE C9H12141776-91-2 3,5-二氟溴苄3,5-Difluorobenzyl bromide C7H5BrF2452-14-2 3-氟-4-甲氧基苯乙酸3-FLUORO-4-METHOXYPHENYLACETICACID C9H9FO3843-55-0 1,1'-双(4-羟基苯基)环己烷4,4'-CyclohexylidenebisphenolC18H20O268302-10-3 3-胺基-6-三氟甲基吡啶2-AMINO-7-CHLORO-5-OXO-5H-(1)BENZOPYRANO-(2,3-B)-PYRIDINE-3-C ARBONITRILE C13H6ClN3O275481-73-1 头孢米诺Cefminox C16H21N7O7S3424-40-8 六氟戊二酸二乙酯DIETHYL HEXAFLUOROGLUTARATEC9H10F6O41315-07-7 硒化锶STRONTIUM SELENIDE SeSr105-50-0 1,3-丙酮二羧酸二乙酯Diethyl 1,3-acetonedicarboxylateC9H14O53378-72-1 N-叔丁基苄胺N-(tert-Butyl)benzylamine C11H17N3068-88-0 B-丁内酯BETA-BUTYROLACTONE C4H6O2175204-90-7 6-(2,2,2-TRIFLUOROETHOXY)NICOTINIC ACIDC8H6F3NO313728-34-2 2，3-萘磺酸二甲基乙酸酯2,3-NAPHTHALENEDICARBOXYLIC ACID DIMETHYL ESTER C14H12O4 576-55-6 3,4,5,6-四溴邻甲酚3,4,5,6-TETRABROMO-O-CRESOLC7H4Br4O23761-23-1 3-氧代环丁烷基羧酸3-Oxocyclobutanecarboxylic acidC5H6O32737-22-6 3-羟基-2,4,6-三溴苯甲醛3-HYDROXY-2,4,6-TRIBROMOBENZALDEHYDE C7H3Br3O226074-52-2 2-溴丁酰溴2-Bromobutyryl bromide C4H6Br2O4712-55-4 磷酸二苯酯DIPHENYL PHOSPHITE C12H11O3P1731-79-9 十二烷二酸二甲酯Dimethyl dodecanedioate C14H26O45574-97-0 四丁基磷酸氢铵Tetrabutylammonium phosphateC48H108N3O4P133831-28-4 3-甲酰吲哚-6-羧酸甲酯METHYL3-FORMYLINDOLE-6-CARBOXYLATE C11H9NO35238-27-7 2-甲基戊酰氯2-METHYLVALERYL CHLORIDE C6H11ClO 20665-85-4 异丁酸香兰酯Vanillin isobutyrate C12H14O451315-07-2 3-硝基-2-氰基吡啶2-Cyano-3-nitropyridine C6H3N3O2 18527-21-4 (4-氟苯基硫)乙腈(4-FLUOROPHENYLTHIO)ACETONITRILE C8H6FNS51064-65-4 1,4-甲苯磺酰基-2,3-异亚丙基苏糖醇(+)-1,4-DI-O-TOSYL-2,3-O-ISOPROPYLIDENE-D-THREITOL C21H26O8S2 7789-78-8 氢化钙CALCIUM HYDRIDE Ca175135-32-7 1-(5-(三氟甲基)-1,3,4-噻唑-2-基)哌嗪2-AMINO-4-(3,4-DIFLUOROPHENYL)THIAZOLE C9H6F2N2S87344-06-7 呱氨托美丁Amtolmetin guacil C24H24N2O52313-87-3 4-乙氧基橘红盐酸盐4-(4-ETHOXYPHENYLAZO)-M-PHENYLENEDIAMINEMONOHYDROCHLORIDE C14H17ClN4O1120-28-1 二十烷酸甲酯,花生酸甲酯C20 ARACHIDIC ACID METHYL ESTER C21H42O277-49-6 2-硝基-2-甲基-1,3-丙二醇2-METHYL-2-NITRO-1,3-PROPANEDIOL C4H9NO4124-48-1 一氯二溴甲烷CHLORODIBROMOMETHANE CHBr2Cl 131980-29-5 BOC-L-3-NITROPHENYLALANINE C14H18N2O613466-41-6 2-羟基-4-甲基吡啶2-Hydroxy-4-methylpyridine C6H7NO 128-03-0 二甲基二硫代氨基甲酸钾Potassium dimethyldithiocarbamateC3H6KNS238465-60-0 氟硼酸铜Copper(II) borofluoride B2CuF813547-70-1 一氯频呐酮1-Chloropinacolone C6H11ClO50675-18-8 四氢吡喃-4-甲醛Tetrahydropyran-4-carbaldehyde C6H10O2 7773-01-5 氯化锰Manganese chloride Cl2Mn2528-16-7 邻苯二甲酸单苄酯PHTHALIC ACID MONOBENZYL ESTERC15H12O4289038-17-1 2-溴-4-氟肉桂酸2-BROMO-4-FLUOROCINNAMIC ACIDC9H6BrFO267747-09-5 咪酰胺Prochloraz C15H16Cl3N3O21075-89-4 3,3-四亚甲基戊二酰亚胺3,3-TetramethyleneglutarimideC9H13NO232324-19-9 邻甲苯磺酰异氰酸酯2-Toluenesulfonyl isocyanateC8H7NO3S1592-23-0 硬脂酸钙Calcium stearate C36H70CaO41122-71-0 6-甲基-2-吡啶基甲醇6-METHYL-2-PYRIDINEMETHANOLC7H9NO4253-34-3 甲基三乙酰氧基硅烷Methyltriacetoxysilane C7H12O6Si 7718-54-9 氯化镍Nickel chloride Cl2Ni103262-35-7 2,3-DIHYDRO-1-BENZOFURAN-5-YLMETHANOLC9H10O2170981-26-7 2-氟-4-甲基苯硼酸2-Fluoro-4-methylphenylboronic acidC7H8BFO2164670-44-4 对吡啶基硫脲4-PYRIDYLTHIOUREA C6H7N3S7116-96-3 对戊基联苯4-N-PENTYLBIPHENYL C17H2017480-69-2 (S)-(-)-N-苄基-alpha-甲基苄胺(S)-(-)-N-Benzyl-1-phenylethylamine C15H17N5815-08-7 叔丁氧基双(二甲胺基)甲烷BREDERECK'S REAGENTC9H22N2O148893-10-1 HATU2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate C10H16F6N6OP13431-36-2 4-ISOPROPYL-3-THIOSEMICARBAZIDE C4H11N3S 20605-41-8 甲氧基乙酸肼METHOXYACETIC ACID HYDRAZIDEC3H8N2O2542-56-3 亚硝酸异丁酯Isobutylnitrite C4H9NO27783-06-4 氢硫酸HYDROGEN SULFIDE H2S60832-72-6 2,3-二氢吡啶并[2,3-d][1,3]唑-2-酮2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one C6H4N2O22133-34-8 (S)-(-)-2-羧基环丁胺(S)-(-)-2-Azetidinecarboxylic acidC4H7NO271759-89-2 4-碘-1(H)-咪唑4-Iodoimidazole C3H3IN274283-34-4 2,4-二氨基苯酚硫酸盐2,4-Diaminophenol sulfateC6H10N2O5S91983-14-1 2-(溴甲基)苯硼酸2-Bromomethylphenylboronic acidC7H8BBrO288-45-9 2,5-二氨基苯磺酸2,5-Diaminobenzenesulfonic acidC6H8N2O3S776-41-0 吲哚-3-甲酸乙酯Ethyl indole-3-carboxylate C11H11NO2863-57-0 甘氨胆酸钠盐GLYCOCHOLIC ACID SODIUM SALTC26H42NNaO6407-22-7 2-氟-6-甲基吡啶2-Fluoro-6-methylpyridine C6H6FN73096-42-1 邻溴四唑5-(2-BROMOPHENYL)-1H-TETRAZOLEC7H5BrN478-26-2 2-甲基-2-丙基-1,3-丙二醇2-Methyl-2-propyl-1,3-propanediolC7H16O268214-07-3 十六烷基三甲基硫酸氢铵Cetyltrimethylammonium hydrogensulfate C19H43NO4S5345-47-1 2-氨基烟酸2-Aminonicotinic acid C6H6N2O282652-12-8 4-(甲基磺酰胺基)苄胺.氯化氢4-(METHYLSULFONYLAMINO)BENZYLAMINE HYDROCHLORIDEC8H13ClN2O2S3096-81-9 4-苯氧基苯腈4-PHENOXYBENZONITRILE C13H9NO 27817-67-0 烯丙基二硫化物ALLYL N-PROPYL SULFIDE C6H12S 5926-26-1 氯甲基三甲氧基硅烷ChloromethyltrimethoxysilaneC4H11ClO3Si39373-27-8 氧化铑(III)五水合物Rhodium(III) oxide pentahydrateH10O8Rh213901-10-5 二氯-3-硝基吡啶2,6-DICHLORO-3-NITROPYRIDINEC5H2Cl2N2O26628-68-8 DIETHYL 2-(PHENYLETHYL)MALONOATE C15H20O4 13478-33-6 高氯酸钴COBALT (II) PERCHLORATE Cl2CoH12O1498-87-3 ALPHA,ALPHA-二氯甲苯(二氯甲苯) BENZAL CHLORIDEC7H6Cl23332-29-4 乙氧基胺盐酸盐Ethoxyamine hydrochloride C2H8ClNO 32832-01-2 胆甾烯基2,4-二氯苯甲酸酯[(3S,8S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3, 4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 2,4-dichlorobenzoate C34H48Cl2O22037-26-5 氘代甲苯TOLUENE-D8 C7D863721-05-1 3,3-二甲基-4-戊烯酸甲酯Methyl 3,3-dimethylpent-4-enoateC8H14O262720-29-0 1,3-二溴-5-氟-2-碘苯1,3-Dibromo-5-fluoro-2-iodobenzeneC6H2Br2FI256642-28-1 2-氨基-4,6-二甲氧基吡啶2-AMINO-4,6-DIMETHOXYPYRIDINE C7H10N2O2494-52-0 硫苯咪唑砜(-)-ANABASINE C10H14N2165727-45-7 (1S,2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER (1S,2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER C15H22ClNO322031-33-0 N-氰乙基-N-乙酰氧乙基苯胺2-[N-(2-Cyanoethyl)anilino]ethyl acetate C13H16N2O2269410-24-4 5-吲哚硼酸频哪醇酯5-Indoleboronic acid pinacol esterC14H20BNO351417-51-7 7-溴吲哚7-Bromoindole C8H6BrN7790-86-5 三氯化铈CERIUM(III) CHLORIDE CeCl32216-52-6 [1S-(1α,2α,5β)]-5-甲基-2-(1-甲基乙基)环己醇(+)-NEOMENTHOL C10H20O89766-91-6 1-羧基-1-甲基乙氧基氯化铵1-Carboxy-1-methylethoxyammonium chloride C4H10ClNO391300-60-6 6-ANILINO-5,8-QUINOLINEDIONE C15H10N2O23164-34-9 酒石酸钙CALCIUM TARTRATE C4H4CaO62106-02-7 2-氯-4-氟苯胺2-Chloro-4-fluoroaniline C6H5ClFN552-59-0 樱黄素Prunetin C16H12O5252990-05-9 (R)-1-Boc-2-哌嗪甲酸甲酯(R)-N-Boc-piperazine-2-carboxylic acid methyl ester C11H20N2O41701-26-4 4-CHLORO-6-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE C11H7ClF3N1330-20-7 二甲苯Xylene C8H1025384-14-9 2'-AMINOACETOPHENONE HYDROCHLORIDEC8H10ClNO6609-56-9 2-甲氧基氰苯2-Methoxybenzonitrile C8H7NO3088-41-3 N-氰乙基哌啶1-Piperidinepropionitrile C8H14N249711-55-9 3-(1,3-BENZODIOXOL-5-YL)-2-CYANOACRYLIC ACIDC11H7NO452938-97-3 5-PHENYL-2-FUROIC ACID C11H8O326447-85-8 2,2-二噻吩基乙醇酸甲酯Methyl 2,2-dithienylglycolateC11H10O3S21484-85-1 3,4-亚甲二氧苯乙胺HOMOPIPERONYLAMINE C9H11NO2 36051-68-0 胞苷5'-三磷酸二钠盐Cytidine 5'-triphosphate disodium salt C9H14N3Na2O14P3561-20-6 硝基马钱子碱CACOTHELINE C21H21N3O7593-71-5 氯碘甲烷Chloroiodomethane CH2ClI2783-17-7 1,12-二氨基十二烷1,12-Dodecanediamine C12H28N22043-55-2 1,1,2,2-四氢全氟己基碘1H,1H,2H,2H-Perfluorohexyl iodideC6H4F9I69478-77-9 3-(DIMETHYLAMINO)PYRROLIDINE C6H14N218549-40-1 1,2-O-异亚丙基-D-呋喃葡萄糖1,2-O-Isopropylidene-D-glucofuranose C9H16O66409-77-4 核固红NUCLEAR FAST RED C14H8NNaO7S12064-62-9 氧化钆Gadolinium oxide Gd2O328752-82-1 邻丙烯基氧基苯甲醛2-ALLYLOXYBENZALDEHYDEC10H10O219780-44-0 4-乙基-3-己醇4-ETHYL-3-HEXANOL C8H18O119-30-2 5-碘水杨酸5-Iodosalicylic acid C7H5IO31713-15-1 2,4-滴异丁酯Isobutyl 2,4-dichlorophenoxyacetateC12H14Cl2O31635-61-6 2-硝基-5-氯苯胺5-Chloro-2-nitroaniline C6H5ClN2O2 155141-29-0 马来酸罗格列酮Rosiglitazone maleate C22H23N3O7S79-19-6 硫代氨基脲N-Aminothiourea CH5N3S452-72-2 4-氟-2-甲基苯酚4-Fluoro-2-methylphenol C7H7FO771-61-9 五氟苯酚Pentafluorophenol C6HF5O654-11-5 3,5-二氟-4-甲氧基苯甲醛3,5-Difluoro-4-methoxybenzaldehyde C8H6F2O299300-78-4 盐酸文拉法辛Venlafaxine hydrochloride C17H28ClNO2 760-21-4 甲基丙烯酸乙酯2-ETHYL-1-BUTENE C6H12127-21-9 二氯四氟丙酮1,3-DICHLOROTETRAFLUOROACETONEC3Cl2F4O103029-74-9 2-CYANO-3-(3-PYRIDINYL)ACRYLIC ACID C9H6N2O2 33513-44-9 苯甲醛-2,4-二磺酸钠Benzaldehyde-2,4-disulfonic acid disodium salt C7H4Na2O7S255031-15-7 2-乙基-3,5-二甲基吡嗪2-Ethyl-3,5-dimethylpyrazineC8H12N2638-21-1 苯基膦Phenyl phosphine C6H7P53912-85-9 L-beta-高脯氨酸盐酸盐L-beta-Homoproline hydrochlorideC6H12ClNO2401-56-9 氯氟乙酸乙酯ETHYL CHLOROFLUOROACETATEC4H6ClFO2219508-62-0 1-BOC-6-AMINOINDOLE C13H16N2O26065-63-0 二丙基丙二酸二乙酯Diethyl dipropylmalonate C13H24O4 63493-28-7 2-氨基戊烷2-AMINOPENTANE C5H13N14763-60-1 4-甲基磺酰苯酚4-Methylsulfonylphenol C7H8O3S3406-03-9 2-(苯基磺酰)苯乙酮2-(PHENYLSULFONYL)ACETOPHENONE C14H12O3S86070-82-8 3-羟基吡咯烷盐酸盐3-Hydroxypyrrolidine hydrochlorideC4H10ClNO82436-77-9 双琥珀酰亚胺辛二酸酯钠盐BS3 C16H18N2Na2O14S2 6967-29-9 2,6-二甲基氯代乙酰苯胺N-CHLOROACETYL-2,6-DIETHYLANILINE C12H16ClNO104-31-4 苯佐那酯Benzonatate C30H53NO11769-11-9 2-氯-6-硝基苯胺2-CHLORO-6-NITROANILINE C6H5ClN2O2 63039-46-3 Boc-D-炔丙基甘氨酸(R)-N-BOC-PropargylglycineC10H15NO4520-45-6 脱氢乙酸Dehydroacetic acid C8H8O422767-90-4 1，1，1-三氟-5，5-二甲基-2，4-己二酮1,1,1-TRIFLUORO-5,5-DIMETHYL-2,4-HEXANEDIONE C8H11F3O2 161265-03-8 4,5-双二苯基膦-9,9-二甲基氧杂蒽Dimethylbisdiphenylphosphinoxanthene C39H32OP2584-94-1 2,3-二甲基己烷2,3-DIMETHYLHEXANE C8H182888-06-4 3-氯苯磺酰氯3-Chlorobenzenesulfonyl chloride C6H4Cl2O2S 67674-48-0 1,1,1,3,3,3-六氟异丙基对甲苯磺酸盐HEXAFLUOROISOPROPYL TOSYLATE C10H8F6O3S619-89-6 对硝基肉桂酸4-Nitrocinnamic acid C9H7NO4114872-98-9 D-2,4-二氯苯丙氨酸D-2,4-DICHLOROPHENYLALANINEC9H9Cl2NO25396-38-3 4-叔丁基茴香醚4-TERT-BUTYLANISOLE C11H16O768-05-8 吡嗪-2-甲酰肼Pyrazinoic acid hydrazide C5H6N4O30955-94-3 2-乙酰基-5-碘噻吩2-ACETYL-5-IODOTHIOPHENEC6H5IOS21324-39-0 六氟磷酸钠Sodium hexafluorophosphate F6NaP75685-01-7 (S)-(-)-2,2'-二甲氧基-1,1'-联萘(R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL C22H18O22374-14-3 三氟丙基甲基环三硅氧烷1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane C12H21F9O3Si3 159275-17-9 4-(溴甲基)哌啶甲酸苄酯BENZYL4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATEC14H18BrNO292828-64-3 BOC-D-ASP(OBZL)-OH C16H21NO657946-56-2 4-氯-2-氟苯胺4-Chloro-2-fluoroaniline C6H5ClFN633-96-5 酸性橙7 Acid Orange 7 C16H11N2NaO4S230295-09-7 2,3,6-三氟苄胺2,3,6-TRIFLUOROBENZYLAMINEC7H6F3N51803-78-2 尼美舒利Nimesulide C13H12N2O5S654-99-9 5-氟-2-三氟甲基苯甲酸5-FLUORO-2-(TRIFLUOROMETHYL)BENZOIC ACID C8H4F4O27720-39-0 2-氨基咪唑2-Aminoimidazole C3H5N31685-33-2 N-苄氧羰基-D-缬氨酸Cbz-D-Valine C13H17NO45908-81-6 钡酒石酸盐BARIUM TARTRATE C4H4BaO61700-10-3 环辛二烯1,3-CYCLOOCTADIENE C8H1250743-18-5 3-氰基-6-甲基色酮3-CYANO-6-METHYLCHROMONEC11H7NO2401-77-4 间氟三氯苄3-FLUOROBENZOTRICHLORIDE C7H4Cl3F 108957-20-6 N-BOC-3-碘-L-丙氨酸苄酯N-BOC-3-IODO-L-ALANINE BENZYL ESTER C15H20INO468121-46-0 3,5-二氯茴香硫醚3,5-DICHLOROTHIOANISOLE C7H6Cl2S 1120-97-4 4-甲基-1,3-二氧六环4-METHYL-1,3-DIOXANE C5H10O2 29973-13-5 乙硫苯威ETHIOFENCARB C11H15NO2S45644-21-1 2-氨基-6-氯吡啶2-Amino-6-chloropyridine C5H5ClN290-22-2 戊沙溴铵Valethamate bromide C19H32BrNO2136725-53-6 3-(S)-氟吡咯烷(HCL) (R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE C4H9ClFN54903-50-3 4,5,6,7-四氢噻吩并[3.2-c]吡啶4,5,6,7-Tetrahydrothieno[3,2-c]pyridine C7H9NS537-47-3 4-苯基氨基脲4-PHENYLSEMICARBAZIDE C7H9N3O50847-11-5 异丁司特Ibudilast C14H18N2O30924-93-7 N-叔丁氧羰基-L-谷氨酸1-苄酯Boc-L-Glutamic acid 1-benzyl ester C17H23NO612037-01-3 氧化铽Tetraterbium heptaoxide O7Tb4-236476-78-5 3-吖丁啶羧酸3-Azetidinecarboxylic acid C4H7NO26188-23-4 6-溴-咪唑并[1,2-a]吡啶6-Bromoimidazo[1,2-a]pyridineC7H5BrN2119-28-8 1-萘胺-7-磺酸1-Naphthylamine-7-sulfonic acid C10H9NO3S 24120-18-1 BIS(1H,1H-PERFLUOROOCTYL)FUMARATE C20H6F30O4 112-84-5 芥酸酰胺cis-13-Docosenoamide C22H43NO140462-76-6 (Z)-11-[3-(二甲基氨基)亚丙基]-6,11-二氢二苯并[b,e]氧杂卓-2-乙酸盐酸盐Olopatadine hydrochloride C21H24ClNO329097-12-9 1-乙基-1,2-二氢-6-羟基-4-甲基-2-氧代-3-吡啶甲酰胺1-Ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridinecarboxamideC9H12N2O3273-09-6 苯并呋喃BENZOFURAZAN C6H4N2O655-07-2 2,4-二硝基三氟甲氧基苯2,4-Dinitro-1-(trifluoromethoxy)benzene C7H3F3N2O533429-83-3 3',5,7-三羟基-3,4'-二甲氧基黄酮3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE C17H14O72516-34-9 环丁基胺Cyclobutylamine C4H9N117482-84-5 3-氯-4-氟苯腈3-Chloro-4-fluorobenzonitrile C7H3ClFN 1844-01-5 4,4'-二苯亚甲基双酚4,4'-DihydroxytetraphenylmethaneC25H20O23344-18-1 柠檬酸镁Trimagnesium dicitrate C12H10Mg3O14648-53-3 2-甲基联苯2-METHYLBIPHENYL C13H125061-21-2 2-溴-gamma-丁内酯2-Bromo-4-butanolide C4H5BrO2 195447-80-4 4-氟-2-(三氟甲基)苯乙酸4-FLUORO-3-(TRIFLUOROMETHYL)PHENYLACETIC ACID C9H6F4O2123-35-3 月桂烯Myrcene C10H1613195-64-7 丙二酸二异丙酯Diisopropyl malonate C9H16O4580-22-3 2-氨基喹啉Quinolin-2-amine C9H8N2138977-28-3 CAPSAZEPINE C19H21ClN2O2S125643-61-0 抗氧化剂1135Octyl-3,5-di-tert-butyl-4-hydroxy-hydrocinnamate C25H42O33108-24-5 全氟辛酸乙酯ETHYL PERFLUOROOCTANOATEC10H5F15O27787-58-8 溴化铋BISMUTH(III) BROMIDE BiBr334598-49-7 5-溴茚酮5-Bromoindanone C9H7BrO2991-28-8 2,5-二氟苯甲酸2,5-Difluorobenzoic acid C7H4F2O264506-49-6 索法酮Sofalcone C27H30O630992-29-1 N-叔丁氧羰基-2-甲基丙氨酸BOC-alpha-MethylalanineC9H17NO45153-25-3 尼泊金辛酯2-Ethylhexyl 4-hydroxybenzoate C15H22O3447-31-4 2-氯-2-苯基苯乙酮DESYL CHLORIDE C14H11ClO86-47-5 7-氯-4-羟基喹啉-3-羧酸7-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID C10H6ClNO3327-62-8 丙酸钾PROPIONIC ACID POTASSIUM SALT C3H5KO2531-67-9 2,2-BIPIPERIDINE C10H20N213194-48-4 灭克磷Mocap C8H19O2PS21461-15-0 钙黄绿素Fluorexon C30H26N2O1119509-11-6 1-甲基-3-苯基哌嗪1-METHYL-3-PHENYLPIPERAZINEC11H16N27698-05-7 氘代盐酸DEUTERIUM CHLORIDE ClD5382-16-1 4-羟基哌啶4-Hydroxypiperidine C5H11NO6148-64-7 丙二酸单乙酯钾盐Ethyl potassium malonate C5H7KO42845-78-5 3-氨基-4-溴-5-苯基吡唑4-BROMO-3-PHENYL-1H-PYRAZOL-5-AMINE C9H8BrN3261723-26-6 5-氯-2-氟苄胺5-CHLORO-2-FLUOROBENZYLAMINEC7H7ClFN175205-84-23-(CHLOROMETHYL)-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZ OLE C10H6ClF3N2O202865-82-5 3-溴-4-氟-苯丙酮3'-BROMO-4'-FLUOROPROPIOPHENONE C9H8BrFO1715-33-9 泼尼松龙琥珀酸钠Prednisolone sodium succinateC46H60Na2O14164470-64-8 4-(FMOC-AMINOMETHYL)BENZOIC ACID C23H19NO4 3524-73-0 5-甲基-1-己烯5-METHYL-1-HEXENE C7H1424806-57-3 DIMETHYLPHENACYLSULFONIUM TETRAFLUOROBORATE C10H13BF4OS5330-98-3 2-氯-3-硝基噻酚2-CHLORO-3-NITROTHIOPHENEC4H2ClNO2S20780-76-1 5-碘吲哚醌5-IODOISATIN C8H4INO25580-80-3 2,3,4,5-四氟苯胺2,3,4,5-Tetrafluoroaniline C6H3F4N50-73-7 2,3,5-三氯苯甲酸2,3,5-Trichlorobenzoic acid C7H3Cl3O2 89415-43-0 4-氨基苯硼酸4-Aminophenylboronic acid C6H8BNO2 29865-90-5 3,4-二甲氧基-5-羟基苯甲醛3,4-Dimethoxy-5-hydroxybenzaldehyde C9H10O4673-84-7 2,6-二甲基-2,4,6-辛三烯2,6-DIMETHYL-2,4,6-OCTATRIENEC10H162044-56-6 十二烷基硫酸锂LITHIUM DODECYL SULFATEC12H25LiO4S79561-82-3 Boc-D-4-溴苯丙氨酸(R)-N-BOC-4-BromophenylalanineC14H18BrNO42392-39-4 地塞米松磷酸钠Dexamethasone 21-phosphate disodium salt C22H28FNa2O8P147762-53-6 Fmoc-O-磷酸基-L-酪氨酸Fmoc-O-Phospho-L-tyrosineC24H22NO8P19064-64-3 3,6-二氯-4-甲基哒嗪3,6-Dichloro-4-methylpyridazineC5H4Cl2N2678-77-3 氯化六氟戊二酸HEXAFLUOROGLUTARYL CHLORIDEC5Cl2F6O22822-41-5 2,3,4-三氟苯酚2,3,4-TRIFLUOROPHENOL C6H3F3O 24484-22-8 5-(4'-氟苯基)戊酸5-(4-FLUOROPHENYL)VALERIC ACIDC11H13FO2624-51-1 3-羟基壬烷3-NONANOL C9H20O20651-71-2 4-丁基苯甲酸4-Butylbenzoic acid C11H14O25736-88-9 4-丁氧基苯甲醛4-N-BUTOXYBENZALDEHYDE C11H14O2 123-32-0 2,5-二甲基吡嗪2,5-Dimethyl pyrazine C6H8N2768-32-1 三甲基苯硅烷PHENYLTRIMETHYLSILANE C9H14Si377-93-5 1,2-二氯四氟环丁-1-烯1,2-DICHLOROTETRAFLUOROCYCLOBUT-1-ENE C4Cl2F478537-14-1 O-叔丁基-D-丝氨酸甲酯盐酸盐O-tert-Butyl-D-serine methyl ester hydrochloride C8H18ClNO3607-81-8 苄基丙二酸二乙酯Diethyl benzylmalonate C14H18O436255-44-4 1-溴-3,3-二甲氧基丙烷3-BROMOPROPIONALDEHYDE DIMETHYL ACETAL C5H11BrO257-85-2 丙酸睾丸素Testosterone propionate C22H32O3155-04-4 2-巯基苯并噻唑锌盐Zinc 2-mercaptobenzothiazoleC14H8N2S4Zn121124-97-8 3-甲酰基-4-甲氧基苯硼酸3-Formyl-4-methoxyphenylboronic acid C8H9BO41571-30-8 8-羟基喹啉-2-羧酸8-HYDROXYQUINOLINE-2-CARBOXYLIC ACID C10H7NO31121-60-4 吡啶-2-甲醛2-Pyridinecarboxaldehyde C6H5NO25185-95-9 2,6-二氯苯甲醛肟2,6-Dichlorobenzaldoxime C7H5Cl2NO1747-60-0 2-氨基-6-甲氧基苯并噻唑2-Amino-6-methoxybenzothiazoleC8H8N2OS645-12-5 5-硝基-2-糠酸5-Nitro-2-furoic acid C5H3NO5220298-96-4 4-氨甲基-N-Boc-苯胺tert-ButylN-[4-(aminomethyl)phenyl]carbamate C12H18N2O2815-17-8 三甲基丙酮酸3,3-Dimethyl-2-oxobutyric acid C6H10O31610-39-5 十二氢苯并菲Dodecahydrotriphenylene C18H24400-93-1 4'-氟-3'-硝基苯乙酮4'-Fluoro-3'-nitroacetophenone C8H6FNO3 16982-21-1 硫代草氨酸乙酯Ethyl thiooxamate C4H7NO2S207974-14-9 4-溴-2,5-二氟苯磺酰氯4-BROMO-2,5-DIFLUOROBENZENESULFONYL CHLORIDEC6H2BrClF2O2S22948-06-7 4-三甲基苯胺N-(TRIPHENYLMETHYL)ANILINE C25H21N 7473-98-5 2-羟基-2-甲基-1-苯基-1-丙酮2-Hydroxy-2-methylpropiophenone C10H12O2209919-30-2 4-氯-2-甲基苯硼酸4-CHLORO-2-METHYLPHENYLBORONIC ACID C7H8BClO281925-81-7 5-甲基-2-庚烯-4-酮5-METHYL-2-HEPTEN-4-ONE C8H14O 24517-64-4 2-氨基-3-氰基吡啶2-Amino-3-cyanopyridine C6H5N31998-66-9 4-BROMO-2,3,5,6-TETRAFLUOROANILINE C6H2BrF4N775-06-4 DL-间酪氨酸3-(3-Hydroxyphenyl)-DL-alanine C9H11NO3553-17-3 愈创木酚碳酸酯Guaiacol carbonate C8H8O417136-36-6 N-苄基甘氨酸N-Benzylglycine C9H11NO22524-03-0 二甲基硫代磷酰氯Dimethyl chlorothiophosphateC2H6ClO2PS584-20-3 3-氨基-4,4,4-三氟丁酸3-AMINO-4,4,4-TRIFLUOROBUTYRIC ACID C4H6F3NO2117872-75-0 芴甲氧羰基-O-苄基-L-苏氨酸Fmoc-THr(Bzl)-OHC26H25NO528711-29-7 1,2,4-TRIAZOLE-1-ACETIC ACID C4H5N3O294569-84-3 2-溴-5-氟苯甲醛2-Bromo-5-fluorobenzaldehyde C7H4BrFO 117-34-0 2,2-二苯基乙酸2,2-Diphenylacetic acid C14H12O270627-17-7 4-[(2,4-DICHLOROBENZYL)OXY]BENZALDEHYDEC14H10Cl2O254512-75-3 1-溴-5-氯戊烷1-Bromo-5-chloropentane C5H10BrCl5376-10-3 1-苯并噻吩-5-基异氰酸酯(1-BENZYL-1H-IMIDAZOL-2-YL)METHANOL C11H12N2O6287-20-3 2,3-DIHYDROXYQUINOXALINE C8H6N2O214925-10-1 2-(甲基氨)三氟甲苯2-(METHYLAMINO)BENZOTRIFLUORIDE C8H8F3N149-91-7 没食子酸Gallic acid C7H6O579538-20-8 3,5-二氟苄醇3,5-Difluorobenzyl alcohol C7H6F2O460-40-2 3,3,3-三氟丙醛3,3,3-Trifluoropropanal C3H3F3O143979-15-1 Boc-L-烯丙基甘氨酸二环己胺盐Boc-L-2-allylglycinedicyclohexylamine salt C22H40N2O479-36-7 二氯乙酰氯Dichloroacetyl chloride C2HCl3O5676-58-4 2,5-二甲基苯并恶唑2,5-Dimethylbenzoxazole C9H9NO 82500-35-4 1-(四羟基糠基)哌嗪1-TETRAHYDROFURFURYL-PIPERAZINE C9H18N2O18194-24-6 二肉豆蔻酰磷脂酰胆碱（DMPC）1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE C36H72NO8P 1999-45-7 DL-ALANYL-DL-PHENYLALANINE C12H16N2O318759-96-1 3-氨基-N-甲基苄胺3-Aminobenzylmethylamine C8H12N2 123333-55-1 4,4'-联吡啶水合物4,4'-Dipyridyl hydrate C10H10N2O 175203-08-4 4-(4-CHLOROPHENYL)PYRIMIDINE-2-THIOLC10H7ClN2S95-11-4 2-氰基-5-降冰片烯5-Norbornene-2-carbonitrile C8H9N1528-74-1 4,4-二硝基联苯4,4'-DINITROBIPHENYL C12H8N2O41131-01-7 2,6-二甲基氯代乙酰苯胺2-Chloro-N-(2,6-dimethylphenyl)acetamide C10H12ClNO745784-12-7 喹啉-2-硼酸2-Quinolinylboronic acid C9H8BNO261924-25-2 3-甲基苄基异氰酸酯3-METHYLBENZYL ISOCYANATEC9H9NO80-08-0 4,4'-二氨基二苯砜4,4'-Diaminodiphenylsulfone C12H12N2O2S 216431-85-5 3-氰基-6-三氟甲基吡啶6-(Trifluoromethyl)nicotinonitrileC7H3F3N2120014-06-4 1-苄基-4-[(5,6-二甲氧基茚满酮-2-基)甲基]哌啶2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-oneC24H29NO359-43-8 维生素B1 Thiamine chloride C12H17ClN4OS1196-69-6 5-吲哚甲醛Indole-5-carboxaldehyde C9H7NO877-42-9 6-溴-2-甲基喹啉6-Bromo-2-methylquinoline C10H8BrN 24032-84-6 4-三氟甲基硫代苯基异氰酸酯4-(TRIFLUOROMETHYLTHIO)PHENYL ISOCYANATE C8H4F3NOS488-43-7 D-萄糖胺D-GLUCAMINE C6H15NO51611-07-0 3,5-二-叔-丁基-4-羟基苯乙腈3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLACETONITRILE C16H23NO 39212-23-2 威士忌内酯Whiskey lactone C9H16O22699-79-8 硫酰氟SULFURYL FLUORIDE F2O2S190190-50-2 BOC-(R)-3-氨基-4,4-二苯基-丁酸BOC-(R)-3-AMINO-4,4-DIPHENYL-BUTYRIC ACID C21H25NO44837-19-8 3-(二氟甲氧基)苯甲酸3-(DIFLUOROMETHOXY)BENZOIC ACID C8H6F2O324589-78-4 N-甲基-N-(三甲基硅烷基)三氟乙酰胺N-Methyl-N-(trimethylsilyl)trifluoroacetamide C6H12F3NOSi3326-32-7 异硫氰酸荧光素酯Fluorescein isothiocyanate isomer IC21H11NO5S532-11-6 茴三硫Anethole trithione C10H8OS31676-75-1 N-苄氧羰基-O-叔丁基-L-丝氨酸N-Cbz-O-tert-butyl-L-serineC15H21NO52065-23-8 苯氧乙酸甲酯Methyl phenoxyacetate C9H10O36027-21-0 D-高丝氨酸D-Homoserine C4H9NO3243666-11-7 2-甲基-6-三氟甲基吡啶-3-羰酰氯4-AMINO-7-(TRIFLUOROMETHYL)QUINOLINE C10H7F3N266609-04-9 异硫代氰2-乙基-6-甲基苯基酸酯2-ETHYL-6-METHYLPHENYL ISOTHIOCYANATE C10H11NS14533-63-2 丙烷磺酸钠Sodium 1-propanesulfonate C3H7NaO3S5292-42-2 2,3,4,5-四氟苯甲酸甲酯2,3,4,5-TETRAFLUORO-BENZOIC ACID METHYL ESTER C8H4F4O2551-08-6 3-正丁烯基苯酞N-BUTYLIDENEPHTHALIDE C12H12O2104-29-0 氯苯甘醚Chlorphenesin C9H11ClO3408-50-4 4-溴-3-氟苯甲醚4-Bromo-3-fluoroanisole C7H6BrFO1577-22-6 5-己烯酸5-HEXENOIC ACID C6H10O21080-44-0 N-对甲苯磺酰甘氨酸N-P-TOSYLGLYCINE C9H11NO4S 32222-06-3 钙三醇1alpha,25-Dihydroxycholecalciferol C27H44O3 80154-34-3 豆腐果苷Helicid C13H16O7381721-55-7 1-(2-IMIDAZOL-1-YL-ETHYL)-PIPERAZINE C9H16N4 65355-30-8 反式-4-戊基环己基苯甲酸4-(trans-4-Pentylcyclohexyl)benzoic acid C18H26O262936-23-6 5-氯香草酸5-CHLOROVANILLIC ACID C8H7ClO423743-26-2 1,2-双(二环己基磷基)-乙烷1,2-BIS(DICYCLOHEXYLPHOSPHINO)ETHANE C26H48P2670-80-4 1-吗啉基-1-环己烯N-(1-Cyclohexen-1-yl)morpholineC10H17NO552-86-3 糠偶因2,2'-Furoin C10H8O413515-97-4 DL-丙氨酸甲酯盐酸盐Methyl DL-2-aminopropanoate hydrochloride C4H10ClNO284806-27-9 7-苯并呋咱-4-磺酸铵7-FLUOROBENZO-2-OXA-1,3-DIAZOLE-4-SULFONIC ACID AMMONIUM SALT C6H6FN3O4S119192-10-8 4-(1H-1,2,4-三氮唑-1-基甲基)苯胺4-(1H-1,2,4-Triazol-1-ylmethyl)aniline C9H10N43430-18-0 2,5-二溴-3-甲基吡啶2,5-Dibromo-3-methylpyridine C6H5Br2N 71581-92-5 顺-(1R,2S)-(+)-苄胺环己烷甲醇(+)-CIS-2-BENZYLAMINOCYCLOHEXANEMETHANOL C14H21NO15952-70-2 2,4-二氟-3,5-二氯硝基苯2,4-Difluoro-3,5-dichloronitrobenzene C6HCl2F2NO2261762-45-2 2-氯-3,6-二氟苄胺2-CHLORO-3,6-DIFLUOROBENZYLAMINE C7H6ClF2N1501-06-0 乙酰戊二酸二乙酯DIETHYL 2-ACETYLGLUTARATEC11H18O51121-31-9 2-巯基吡啶-N-氧化物2-Pyridinethiol 1-oxide C5H5NOS32737-14-7 2-乙氧基-3-甲基吡嗪2-Ethoxy-3-methylpyrazine C7H10N2O 43064-12-6 4-苯基-1,2,3,6-四氢吡啶盐酸盐4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride C11H14ClN56-06-4 2,4-二氨基-6-羟基嘧啶2,4-Diamino-6-hydroxypyrimidineC4H6N4O95-89-6 3-氯-2,5-二甲基吡嗪3-CHLORO-2,5-DIMETHYLPYRAZINEC6H7ClN214273-86-0 5-氯戊酸甲酯Methyl 5-chloropentanoate C6H11ClO2 141179-72-8 4-氟-2-(三氟甲基)苯甲酸4-FLUORO-2-(TRIFLUOROMETHYL)BENZOIC ACID C8H4F4O22493-02-9 4-溴异氰酸苯酯4-BROMOPHENYL ISOCYANATEC7H4BrNO500912-12-9 2-氟-6-甲氧基苄氯2-Fluoro-6-methoxybenzoyl chloridC8H6ClFO239835-14-8 2-HYDROXY-4-NITROBENZONITRILE C7H4N2O32365-48-2 巯基乙酸甲酯Methyl thioglycolate C3H6O2S142-31-4 辛基硫酸钠Sodium octyl sulfate C8H17NaO4S52509-14-5 (1,3-二氧戊环-2-基)甲基三苯基溴化瞵(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide C22H22BrO2P 1665-48-1 美他沙酮Metaxalone C12H15NO313450-92-5 溴化锗GERMANIUM TETRABROMIDE Br4Ge45102-52-1 2,2,3,3-四氟丙基甲基丙烯酸酯2,2,3,3-Tetrafluoropropyl methacrylate C7H8F4O235854-86-5 (Z)-6-壬烯-1-醇cis-6-Nonen-1-ol C9H18O145038-50-2 Fmoc-L-谷氨酸gamma-甲酯Fmoc-L-Glutamic acid gamma-methyl ester C21H21NO61459-10-5 十四烷基苯TETRADECYLBENZENE C20H3420535-83-5 2-氨基-6-甲氧基嘌呤6-Methoxyguanine C6H8N5O21508-65-2 盐酸奥昔布宁Oxybutynin hydrochloride C22H32ClNO3 39267-74-8 2,5,6-三氨基-4-嘧啶醇硫酸盐6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE SULFATE C4H9N5O5S 36768-62-4 2,2,6,6-四甲基哌啶胺Triacetonediamine C9H20N2O33943-89-3 3,4-二羟基苯甲酸乙酯Ethyl 3,4-dihydroxybenzoate C9H10O4 94-74-6 2-甲基-4-氯苯氧乙酸2-Methyl-4-chlorophenoxyacetic acidC9H9ClO35989-81-1 alpha-D-乳糖单水合物ALPHA-LACTOSE MONOHYDRATEC12H24O12614-72-2 鄰氯苯基乙基醚2-CHLOROPHENETOLE C8H9ClO54406-48-3 右旋反式炔戊菊酯Empenthrin C18H25O2-155206-00-1 比马前列素Bimatoprost C25H37NO493-07-2 3,4-二甲氧基苯甲酸3,4-Dimethoxybenzoic acid C9H10O4 2437-25-4 十二腈Dodecanenitrile C12H23N50262-48-1 4-丙烯氧基苯甲醛4-PROPIONYLOXYBENZALDEHYDEC10H10O3。

纳米钯_乙二醇体系催化Suzuki反应的研究

·94·
广州化工
2009年 37卷第 6期
2 结果与讨论
211 碱对 Suzuk i反应的影响
碱对偶联反应的影响是比较明显的。因此我们以对甲氧基溴苯和苯硼酸作为基准反应 ,以不同的碱进行 Suzuki反应 ,从中选择最合适的碱试剂。我们发现 ,该体系下 , K2 CO3、NaOH、NaH2 CO3 的效果都比较好。其他的碱试剂 ,如 K3 PO4 ·3H2O、Na3 PO4 ·12H2O、Na2 HPO4 ·12H2O ,相对产率都较低。相比之下 ,我们选择相对较廉价的 K2 CO3 作为该体系的碱试剂。
表 1 不同碱对 Suzuki反应的影响
碱
产率 / %
Na2 CO3
63
N aHCO 3
81
K2 CO3
84
KF·2H2O
39
KOH
48
N aOH
83
K3 PO4 ·3H2O
77
Na3 PO4 ·12H2O
73
Na2 HPO4 ·12H2O
72
212 温度对 Suzuk i反应的影响
考察了温度对 Suzuki反应影响。以对甲氧基溴苯和苯硼酸作为底物作为模型反应。实验结果见表 2。
表 2 不同温度对 Suzuki反应产率的影响
温度 / ℃
产率 / %
60
72
70
77
80
84
90
83
100
85
实验结果表明 , 产率随着温度上升有小幅度上升。达到 80℃之后 ,再继续升温对产率则几乎没有什么影响。反应温度为 80℃为宜。
213 催化剂用量对 Suzuk i反应的影响

常见化学品CAS号列表

常见化学品CAS号列表CAS 中文名称英文名称MF51762-67-5 3-硝基邻苯二腈3-Nitrophthalonitrile C8H3N3O25446-18-4 2,4-二氯苯肼盐酸盐2,4-Dichlorophenylhydrazine hydrochloride C6H7Cl3N247250-53-3 2,2-BIS(3-AMINOPHENYL)HEXAFLUOROPROPANEC15H12F6N22380-78-1 4-羟基-3-甲氧基苯乙醇Homovanillyl alcohol C9H12O31712-70-5 对氯甲基苯乙烯4-Chloro-alpha-methylstyrene C9H9Cl935-30-8 2-氮杂环壬酮2-AZACYCLONONANONE C8H15NO3012-65-5 柠檬酸氢二铵Ammonium citrate dibasic C6H14N2O71912-28-3 2-(N-吗啉）乙烷磺酸MES C6H13NO4S91-10-1 2,6-二甲氧基苯酚2,6-Dimethoxyphenol C8H10O3261944-56-3 5-氨基-2,4-二氟三氟甲苯5-AMINO-2,4-DIFLUOROBENZOTRIFLUORIDE C7H4F5N2415-85-2 4'-甲基乙酰乙酰苯胺N-(4-Methylphenyl)-3-oxobutanamideC11H13NO2460-43-5 2,2,2-三氟乙基甲基醚2,2,2-TRIFLUOROETHYL METHYL ETHER C3H5F3O10101-53-8 硫酸铬Chromic sulfate Cr2O12S36850-28-8 三羟甲基氨基甲烷醋酸盐Tris(hydroxymethyl)aminomethane acetate salt C16H31N3O131120-01-0 正十六烷基硫酸钠N-HEXADECYLSULFURIC ACID SODIUM SALT C16H33NaO4S112809-25-3 4-(1H-1,2,4-三唑-1-基甲基)苯甲腈4-(1H-1,2,4-Triazol-1-ylmethyl)benzonitrile C10H8N4592-85-8 硫氰酸汞(II) MERCURIC THIOCYANATE C2HgN2S2223463-13-6 5-溴-2-碘吡啶5-Bromo-2-iodopyridine C5H3BrIN4343-75-3 4-AMINO-4H-1,2,4-TRIAZOLE-3-THIOL C2H4N4S14794-31-1 丁二酸单乙酯酰氯Ethyl 3-(chloroformyl)propionateC6H9ClO3726-25-0 1-BENZYL-3-PHENYL-2-THIOUREA C14H14N2S207974-20-7 3-氟-5-(三氟甲基)苯丙酮3'-FLUORO-5'-(TRIFLUOROMETHYL)PROPIOPHENONE C10H8F4O 1314-41-6 四氧化三铅Lead oxide OPb36725-28-7 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone C11H13N3O 74938-88-8 (4-脒苯基)甲磺酰氟盐酸盐4-Amidinophenylmethanesulfonyl fluoride hydrochloride C8H10ClFN2O2S94-67-7 水杨醛肟Salicylaldoxime C7H7NO256860-82-3 1,1,2,3,3,3-HEXAFLUOROPROPYL DICHLOROMETHYL ETHER C4H2Cl2F6O90090-64-5 2-(噻吩-2-基)吡咯烷2-(Thien-2-yl)pyrrolidine C8H11NS621-42-1 N-(3-羟基苯基)乙酰胺3-ACETAMIDOPHENOL C8H9NO2554-07-4 氰金(I)酸钾POTASSIUM DICYANOAURATE(I) C2AuKN2 34312-77-1 反式-2-(2-硝基乙烯基)噻吩(E)-2-(2-Nitroethenyl)thiopheneC6H5NO2S117391-52-3 3-氨基-3-(4-乙基苯基)丙酸3-AMINO-3-(4-ETHYLPHENYL)PROPANOIC ACID C11H15NO224631-29-6 N,N-二甲基对苯二胺草酸盐N,N-DIMETHYL-1,4-PHENYLENEDIAMINE OXALATE C10H14N2O4 33898-90-7 2-噻吩基乙酰腈2-THENOYLACETONITRILE C7H5NOS 101-94-0 苯乙酸对甲酚酯p-Tolyl phenylacetate C15H14O294461-44-6 2,4-二甲基吡咯-3,5-二羧酸二叔丁酯Di-(tert-butyl)3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate C16H25NO45378-49-4 5-氨基四氮唑5-AMINO-1H-TETRAZOLE CH3N598-52-2 4-叔丁基环己醇4-tert-Butylcyclohexanol C10H20O59-88-1 盐酸苯肼Phenylhydrazine hydrochloride C6H9ClN210378-47-9 硫酸铈铵AMMONIUM CERIUM(IV) SULFATE DIHYDRATE CeH20N4O18S419099-93-5 1-Cbz-4-哌啶酮1-Cbz-4-Piperidone C13H15NO315045-43-9 2,2,5,5-四甲基四氢呋喃2,2,5,5-TETRAMETHYLTETRAHYDROFURAN C8H16O635-21-2 2-氨基-5-氯苯甲酸2-Amino-5-chlorobenzoic acid C7H6ClNO2 56-69-9 5-羟基色氨酸5-Hydroxytryptophan C11H12N2O3538-28-3 S-苄基硫脲盐酸盐2-Benzyl-2-thiopseudourea hydrochlorideC8H11ClN2S623-17-6 乙酸糠酯Furfuryl acetate C7H8O352709-83-8 4'-正丁基-4-氰基联苯4'-Butyl-4-biphenylcarbonitrileC17H17N618-80-4 2,6-二氯-4-硝基苯酚2,6-Dichloro-4-nitrophenol C6H3Cl2NO3 811-98-3 氘代甲醇METHANOL-D4 CD4O18511-62-1 (±)-4-氟苯乙烯环氧化物,98%2-(4-FLUOROPHENYL)OXIRANE C8H7FO96989-50-3 二吡啶硫碳酸酯DI-2-PYRIDYL THIONOCARBONATEC11H8N2O2S74-39-5 偶氧紫4-(4-NITROPHENYLAZO)RESORCINOL C12H9N3O4 156-41-2 4-氯苯乙胺4-Chlorophenethylamine C8H10ClN446-09-3 2-溴-5-氟硝基苯1-BROMO-4-FLUORO-2-NITROBENZENEC6H3BrFNO2113028-17-4 6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯Ethyl6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-car boxylate C18H20FN3O3S693-16-3 2-辛胺2-AMINOOCTANE C8H19N93-48-1 2,5-二甲基苄胺2,5-Dimethylbenzylamine C9H13N19604-05-8 磷酸肌酸酐二钠盐Disodium(1-methyl-4-oxoimidazolidin-2-ylidene)phosphoramidate C4H6N3Na2O4P 1693-86-3 3-己基噻吩3-Hexylthiophene C10H16S128-97-2 1,4,5,8-萘四甲酸1,4,5,8-Naphthalenetetracarboxylic acidC14H8O827465-51-6 对乙基苯丙酮4'-Ethylpropiophenone C11H14O97165-77-0 3,5-二溴苄腈3,5-DIBROMOBENZONITRILE C7H3Br2N 383127-25-1 2-(呋喃-3-基)吡咯烷2-Furan-3-ylpyrrolidine C8H11NO 86375-28-2 3-(TERT-OCTYLAMINO)PROPIONITRILE C11H22N22615-11-4 4-ACETYLPHENYL ETHER C16H14O37464-14-4 2-羟基-5-甲基-3-硝基吡啶2-Hydroxy-5-methyl-3-nitropyridineC6H6N2O3175278-33-8 2-二氟甲氧基溴苯2-(DIFLUOROMETHOXY)BROMOBENZENE C7H5BrF2O54773-19-2 2,3-二氯三氟甲苯2,3-Dichlorobenzotrifluoride C7H3Cl2F3 14464-32-5 N-羟基琥珀酰亚胺硬酯酸酯Stearic acid-N-hydroxysuccinimide ester C22H39NO4163702-05-4 ETHYL NONAFLUOROBUTYL ETHER C6H5F9O1083-30-3 ω-苄基苯乙酮BETA-PHENYLPROPIOPHENONE C15H14O 6131-99-3 二甲砷酸钠三水合物Sodium cacodylate trihydrateC2H12AsNaO5141774-61-0 2-(叔丁氧羰基氨基甲基)-哌啶2-(Boc-aminomethyl)-piperidine C11H22N2O2754-96-1 十六氟-1，10-癸二醇1H,1H,10H,10H-PERFLUORO-1,10-DECANEDIOL C10H6F16O2132664-85-8 2-氨甲基-5-甲基吡嗪2-(AMINOMETHYL)-5-METHYLPYRAZINE C6H9N3458532-84-8 2-氯吡啶-4-硼酸频哪醇酯2-Chloropyridine-4-boronic acid pinacol ester C11H17BClNO361830-21-5 2-氨基-5-溴噻唑-4-甲酸乙酯Ethyl2-amino-5-bromothiazole-4-carboxylate C6H7BrN2O2S41085-43-2 2-溴-3-硝基甲苯2-Bromo-3-nitrotoluene C7H6BrNO289-69-0 2,4,5-三氯硝基苯1,2,4-Trichloro-5-nitrobenzene C6H2Cl3NO2 2657-87-6 3,4'-二氨基二苯醚3,4'-Oxydianiline C12H12N2O20289-44-5 4-氨基吡唑嘧啶4-AMINOPYRAZOLO[3,4-D]PYRIMIDINEC5H5N5381233-96-1 2-氨基-3-碘-5-溴吡啶2-AMINO-5-BROMO-3-IODOPYRIDINE C5H4BrIN2127733-40-8 (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL C10H10ClF6N26750-81-2 阿利苯多Alibendol C13H17NO42396-65-8 1,8-壬二炔1,8-NONADIYNE C9H12141776-91-2 3,5-二氟溴苄3,5-Difluorobenzyl bromide C7H5BrF2452-14-2 3-氟-4-甲氧基苯乙酸3-FLUORO-4-METHOXYPHENYLACETICACID C9H9FO3843-55-0 1,1'-双(4-羟基苯基)环己烷4,4'-CyclohexylidenebisphenolC18H20O268302-10-3 3-胺基-6-三氟甲基吡啶2-AMINO-7-CHLORO-5-OXO-5H-(1)BENZOPYRANO-(2,3-B)-PYRIDINE-3-C ARBONITRILE C13H6ClN3O275481-73-1 头孢米诺Cefminox C16H21N7O7S3424-40-8 六氟戊二酸二乙酯DIETHYL HEXAFLUOROGLUTARATEC9H10F6O41315-07-7 硒化锶STRONTIUM SELENIDE SeSr105-50-0 1,3-丙酮二羧酸二乙酯Diethyl 1,3-acetonedicarboxylateC9H14O53378-72-1 N-叔丁基苄胺N-(tert-Butyl)benzylamine C11H17N3068-88-0 B-丁内酯BETA-BUTYROLACTONE C4H6O2175204-90-7 6-(2,2,2-TRIFLUOROETHOXY)NICOTINIC ACIDC8H6F3NO313728-34-2 2，3-萘磺酸二甲基乙酸酯2,3-NAPHTHALENEDICARBOXYLIC ACID DIMETHYL ESTER C14H12O4 576-55-6 3,4,5,6-四溴邻甲酚3,4,5,6-TETRABROMO-O-CRESOLC7H4Br4O23761-23-1 3-氧代环丁烷基羧酸3-Oxocyclobutanecarboxylic acidC5H6O32737-22-6 3-羟基-2,4,6-三溴苯甲醛3-HYDROXY-2,4,6-TRIBROMOBENZALDEHYDE C7H3Br3O226074-52-2 2-溴丁酰溴2-Bromobutyryl bromide C4H6Br2O4712-55-4 磷酸二苯酯DIPHENYL PHOSPHITE C12H11O3P1731-79-9 十二烷二酸二甲酯Dimethyl dodecanedioate C14H26O45574-97-0 四丁基磷酸氢铵Tetrabutylammonium phosphateC48H108N3O4P133831-28-4 3-甲酰吲哚-6-羧酸甲酯METHYL3-FORMYLINDOLE-6-CARBOXYLATE C11H9NO35238-27-7 2-甲基戊酰氯2-METHYLVALERYL CHLORIDE C6H11ClO 20665-85-4 异丁酸香兰酯Vanillin isobutyrate C12H14O451315-07-2 3-硝基-2-氰基吡啶2-Cyano-3-nitropyridine C6H3N3O2 18527-21-4 (4-氟苯基硫)乙腈(4-FLUOROPHENYLTHIO)ACETONITRILE C8H6FNS51064-65-4 1,4-甲苯磺酰基-2,3-异亚丙基苏糖醇(+)-1,4-DI-O-TOSYL-2,3-O-ISOPROPYLIDENE-D-THREITOL C21H26O8S2 7789-78-8 氢化钙CALCIUM HYDRIDE Ca175135-32-7 1-(5-(三氟甲基)-1,3,4-噻唑-2-基)哌嗪2-AMINO-4-(3,4-DIFLUOROPHENYL)THIAZOLE C9H6F2N2S87344-06-7 呱氨托美丁Amtolmetin guacil C24H24N2O52313-87-3 4-乙氧基橘红盐酸盐4-(4-ETHOXYPHENYLAZO)-M-PHENYLENEDIAMINEMONOHYDROCHLORIDE C14H17ClN4O1120-28-1 二十烷酸甲酯,花生酸甲酯C20 ARACHIDIC ACID METHYL ESTER C21H42O277-49-6 2-硝基-2-甲基-1,3-丙二醇2-METHYL-2-NITRO-1,3-PROPANEDIOL C4H9NO4124-48-1 一氯二溴甲烷CHLORODIBROMOMETHANE CHBr2Cl 131980-29-5 BOC-L-3-NITROPHENYLALANINE C14H18N2O613466-41-6 2-羟基-4-甲基吡啶2-Hydroxy-4-methylpyridine C6H7NO 128-03-0 二甲基二硫代氨基甲酸钾Potassium dimethyldithiocarbamateC3H6KNS238465-60-0 氟硼酸铜Copper(II) borofluoride B2CuF813547-70-1 一氯频呐酮1-Chloropinacolone C6H11ClO50675-18-8 四氢吡喃-4-甲醛Tetrahydropyran-4-carbaldehyde C6H10O2 7773-01-5 氯化锰Manganese chloride Cl2Mn2528-16-7 邻苯二甲酸单苄酯PHTHALIC ACID MONOBENZYL ESTERC15H12O4289038-17-1 2-溴-4-氟肉桂酸2-BROMO-4-FLUOROCINNAMIC ACIDC9H6BrFO267747-09-5 咪酰胺Prochloraz C15H16Cl3N3O21075-89-4 3,3-四亚甲基戊二酰亚胺3,3-TetramethyleneglutarimideC9H13NO232324-19-9 邻甲苯磺酰异氰酸酯2-Toluenesulfonyl isocyanateC8H7NO3S1592-23-0 硬脂酸钙Calcium stearate C36H70CaO41122-71-0 6-甲基-2-吡啶基甲醇6-METHYL-2-PYRIDINEMETHANOLC7H9NO4253-34-3 甲基三乙酰氧基硅烷Methyltriacetoxysilane C7H12O6Si 7718-54-9 氯化镍Nickel chloride Cl2Ni103262-35-7 2,3-DIHYDRO-1-BENZOFURAN-5-YLMETHANOLC9H10O2170981-26-7 2-氟-4-甲基苯硼酸2-Fluoro-4-methylphenylboronic acidC7H8BFO2164670-44-4 对吡啶基硫脲4-PYRIDYLTHIOUREA C6H7N3S7116-96-3 对戊基联苯4-N-PENTYLBIPHENYL C17H2017480-69-2 (S)-(-)-N-苄基-alpha-甲基苄胺(S)-(-)-N-Benzyl-1-phenylethylamine C15H17N5815-08-7 叔丁氧基双(二甲胺基)甲烷BREDERECK'S REAGENTC9H22N2O148893-10-1 HATU2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate C10H16F6N6OP13431-36-2 4-ISOPROPYL-3-THIOSEMICARBAZIDE C4H11N3S 20605-41-8 甲氧基乙酸肼METHOXYACETIC ACID HYDRAZIDEC3H8N2O2542-56-3 亚硝酸异丁酯Isobutylnitrite C4H9NO27783-06-4 氢硫酸HYDROGEN SULFIDE H2S60832-72-6 2,3-二氢吡啶并[2,3-d][1,3]唑-2-酮2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one C6H4N2O22133-34-8 (S)-(-)-2-羧基环丁胺(S)-(-)-2-Azetidinecarboxylic acidC4H7NO271759-89-2 4-碘-1(H)-咪唑4-Iodoimidazole C3H3IN274283-34-4 2,4-二氨基苯酚硫酸盐2,4-Diaminophenol sulfateC6H10N2O5S91983-14-1 2-(溴甲基)苯硼酸2-Bromomethylphenylboronic acidC7H8BBrO288-45-9 2,5-二氨基苯磺酸2,5-Diaminobenzenesulfonic acidC6H8N2O3S776-41-0 吲哚-3-甲酸乙酯Ethyl indole-3-carboxylate C11H11NO2863-57-0 甘氨胆酸钠盐GLYCOCHOLIC ACID SODIUM SALTC26H42NNaO6407-22-7 2-氟-6-甲基吡啶2-Fluoro-6-methylpyridine C6H6FN73096-42-1 邻溴四唑5-(2-BROMOPHENYL)-1H-TETRAZOLEC7H5BrN478-26-2 2-甲基-2-丙基-1,3-丙二醇2-Methyl-2-propyl-1,3-propanediolC7H16O268214-07-3 十六烷基三甲基硫酸氢铵Cetyltrimethylammonium hydrogensulfate C19H43NO4S5345-47-1 2-氨基烟酸2-Aminonicotinic acid C6H6N2O282652-12-8 4-(甲基磺酰胺基)苄胺.氯化氢4-(METHYLSULFONYLAMINO)BENZYLAMINE HYDROCHLORIDEC8H13ClN2O2S3096-81-9 4-苯氧基苯腈4-PHENOXYBENZONITRILE C13H9NO 27817-67-0 烯丙基二硫化物ALLYL N-PROPYL SULFIDE C6H12S 5926-26-1 氯甲基三甲氧基硅烷ChloromethyltrimethoxysilaneC4H11ClO3Si39373-27-8 氧化铑(III)五水合物Rhodium(III) oxide pentahydrateH10O8Rh213901-10-5 二氯-3-硝基吡啶2,6-DICHLORO-3-NITROPYRIDINEC5H2Cl2N2O26628-68-8 DIETHYL 2-(PHENYLETHYL)MALONOATE C15H20O4 13478-33-6 高氯酸钴COBALT (II) PERCHLORATE Cl2CoH12O1498-87-3 ALPHA,ALPHA-二氯甲苯(二氯甲苯) BENZAL CHLORIDEC7H6Cl23332-29-4 乙氧基胺盐酸盐Ethoxyamine hydrochloride C2H8ClNO 32832-01-2 胆甾烯基2,4-二氯苯甲酸酯[(3S,8S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3, 4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 2,4-dichlorobenzoate C34H48Cl2O22037-26-5 氘代甲苯TOLUENE-D8 C7D863721-05-1 3,3-二甲基-4-戊烯酸甲酯Methyl 3,3-dimethylpent-4-enoateC8H14O262720-29-0 1,3-二溴-5-氟-2-碘苯1,3-Dibromo-5-fluoro-2-iodobenzeneC6H2Br2FI256642-28-1 2-氨基-4,6-二甲氧基吡啶2-AMINO-4,6-DIMETHOXYPYRIDINE C7H10N2O2494-52-0 硫苯咪唑砜(-)-ANABASINE C10H14N2165727-45-7 (1S,2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER (1S,2S)-(1-BENZYL-3-CHLORO-2-HYDROXY-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER C15H22ClNO322031-33-0 N-氰乙基-N-乙酰氧乙基苯胺2-[N-(2-Cyanoethyl)anilino]ethyl acetate C13H16N2O2269410-24-4 5-吲哚硼酸频哪醇酯5-Indoleboronic acid pinacol esterC14H20BNO351417-51-7 7-溴吲哚7-Bromoindole C8H6BrN7790-86-5 三氯化铈CERIUM(III) CHLORIDE CeCl32216-52-6 [1S-(1α,2α,5β)]-5-甲基-2-(1-甲基乙基)环己醇(+)-NEOMENTHOL C10H20O89766-91-6 1-羧基-1-甲基乙氧基氯化铵1-Carboxy-1-methylethoxyammonium chloride C4H10ClNO391300-60-6 6-ANILINO-5,8-QUINOLINEDIONE C15H10N2O23164-34-9 酒石酸钙CALCIUM TARTRATE C4H4CaO62106-02-7 2-氯-4-氟苯胺2-Chloro-4-fluoroaniline C6H5ClFN552-59-0 樱黄素Prunetin C16H12O5252990-05-9 (R)-1-Boc-2-哌嗪甲酸甲酯(R)-N-Boc-piperazine-2-carboxylic acid methyl ester C11H20N2O41701-26-4 4-CHLORO-6-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE C11H7ClF3N1330-20-7 二甲苯Xylene C8H1025384-14-9 2'-AMINOACETOPHENONE HYDROCHLORIDEC8H10ClNO6609-56-9 2-甲氧基氰苯2-Methoxybenzonitrile C8H7NO3088-41-3 N-氰乙基哌啶1-Piperidinepropionitrile C8H14N249711-55-9 3-(1,3-BENZODIOXOL-5-YL)-2-CYANOACRYLIC ACIDC11H7NO452938-97-3 5-PHENYL-2-FUROIC ACID C11H8O326447-85-8 2,2-二噻吩基乙醇酸甲酯Methyl 2,2-dithienylglycolateC11H10O3S21484-85-1 3,4-亚甲二氧苯乙胺HOMOPIPERONYLAMINE C9H11NO2 36051-68-0 胞苷5'-三磷酸二钠盐Cytidine 5'-triphosphate disodium salt C9H14N3Na2O14P3561-20-6 硝基马钱子碱CACOTHELINE C21H21N3O7593-71-5 氯碘甲烷Chloroiodomethane CH2ClI2783-17-7 1,12-二氨基十二烷1,12-Dodecanediamine C12H28N22043-55-2 1,1,2,2-四氢全氟己基碘1H,1H,2H,2H-Perfluorohexyl iodideC6H4F9I69478-77-9 3-(DIMETHYLAMINO)PYRROLIDINE C6H14N218549-40-1 1,2-O-异亚丙基-D-呋喃葡萄糖1,2-O-Isopropylidene-D-glucofuranose C9H16O66409-77-4 核固红NUCLEAR FAST RED C14H8NNaO7S12064-62-9 氧化钆Gadolinium oxide Gd2O328752-82-1 邻丙烯基氧基苯甲醛2-ALLYLOXYBENZALDEHYDEC10H10O219780-44-0 4-乙基-3-己醇4-ETHYL-3-HEXANOL C8H18O119-30-2 5-碘水杨酸5-Iodosalicylic acid C7H5IO31713-15-1 2,4-滴异丁酯Isobutyl 2,4-dichlorophenoxyacetateC12H14Cl2O31635-61-6 2-硝基-5-氯苯胺5-Chloro-2-nitroaniline C6H5ClN2O2 155141-29-0 马来酸罗格列酮Rosiglitazone maleate C22H23N3O7S79-19-6 硫代氨基脲N-Aminothiourea CH5N3S452-72-2 4-氟-2-甲基苯酚4-Fluoro-2-methylphenol C7H7FO771-61-9 五氟苯酚Pentafluorophenol C6HF5O654-11-5 3,5-二氟-4-甲氧基苯甲醛3,5-Difluoro-4-methoxybenzaldehyde C8H6F2O299300-78-4 盐酸文拉法辛Venlafaxine hydrochloride C17H28ClNO2 760-21-4 甲基丙烯酸乙酯2-ETHYL-1-BUTENE C6H12127-21-9 二氯四氟丙酮1,3-DICHLOROTETRAFLUOROACETONEC3Cl2F4O103029-74-9 2-CYANO-3-(3-PYRIDINYL)ACRYLIC ACID C9H6N2O2 33513-44-9 苯甲醛-2,4-二磺酸钠Benzaldehyde-2,4-disulfonic acid disodium salt C7H4Na2O7S255031-15-7 2-乙基-3,5-二甲基吡嗪2-Ethyl-3,5-dimethylpyrazineC8H12N2638-21-1 苯基膦Phenyl phosphine C6H7P53912-85-9 L-beta-高脯氨酸盐酸盐L-beta-Homoproline hydrochlorideC6H12ClNO2401-56-9 氯氟乙酸乙酯ETHYL CHLOROFLUOROACETATEC4H6ClFO2219508-62-0 1-BOC-6-AMINOINDOLE C13H16N2O26065-63-0 二丙基丙二酸二乙酯Diethyl dipropylmalonate C13H24O4 63493-28-7 2-氨基戊烷2-AMINOPENTANE C5H13N14763-60-1 4-甲基磺酰苯酚4-Methylsulfonylphenol C7H8O3S3406-03-9 2-(苯基磺酰)苯乙酮2-(PHENYLSULFONYL)ACETOPHENONE C14H12O3S86070-82-8 3-羟基吡咯烷盐酸盐3-Hydroxypyrrolidine hydrochlorideC4H10ClNO82436-77-9 双琥珀酰亚胺辛二酸酯钠盐BS3 C16H18N2Na2O14S2 6967-29-9 2,6-二甲基氯代乙酰苯胺N-CHLOROACETYL-2,6-DIETHYLANILINE C12H16ClNO104-31-4 苯佐那酯Benzonatate C30H53NO11769-11-9 2-氯-6-硝基苯胺2-CHLORO-6-NITROANILINE C6H5ClN2O2 63039-46-3 Boc-D-炔丙基甘氨酸(R)-N-BOC-PropargylglycineC10H15NO4520-45-6 脱氢乙酸Dehydroacetic acid C8H8O422767-90-4 1，1，1-三氟-5，5-二甲基-2，4-己二酮1,1,1-TRIFLUORO-5,5-DIMETHYL-2,4-HEXANEDIONE C8H11F3O2 161265-03-8 4,5-双二苯基膦-9,9-二甲基氧杂蒽Dimethylbisdiphenylphosphinoxanthene C39H32OP2584-94-1 2,3-二甲基己烷2,3-DIMETHYLHEXANE C8H182888-06-4 3-氯苯磺酰氯3-Chlorobenzenesulfonyl chloride C6H4Cl2O2S 67674-48-0 1,1,1,3,3,3-六氟异丙基对甲苯磺酸盐HEXAFLUOROISOPROPYL TOSYLATE C10H8F6O3S619-89-6 对硝基肉桂酸4-Nitrocinnamic acid C9H7NO4114872-98-9 D-2,4-二氯苯丙氨酸D-2,4-DICHLOROPHENYLALANINEC9H9Cl2NO25396-38-3 4-叔丁基茴香醚4-TERT-BUTYLANISOLE C11H16O768-05-8 吡嗪-2-甲酰肼Pyrazinoic acid hydrazide C5H6N4O30955-94-3 2-乙酰基-5-碘噻吩2-ACETYL-5-IODOTHIOPHENEC6H5IOS21324-39-0 六氟磷酸钠Sodium hexafluorophosphate F6NaP75685-01-7 (S)-(-)-2,2'-二甲氧基-1,1'-联萘(R)-(+)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL C22H18O22374-14-3 三氟丙基甲基环三硅氧烷1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane C12H21F9O3Si3 159275-17-9 4-(溴甲基)哌啶甲酸苄酯BENZYL4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATEC14H18BrNO292828-64-3 BOC-D-ASP(OBZL)-OH C16H21NO657946-56-2 4-氯-2-氟苯胺4-Chloro-2-fluoroaniline C6H5ClFN633-96-5 酸性橙7 Acid Orange 7 C16H11N2NaO4S230295-09-7 2,3,6-三氟苄胺2,3,6-TRIFLUOROBENZYLAMINEC7H6F3N51803-78-2 尼美舒利Nimesulide C13H12N2O5S654-99-9 5-氟-2-三氟甲基苯甲酸5-FLUORO-2-(TRIFLUOROMETHYL)BENZOIC ACID C8H4F4O27720-39-0 2-氨基咪唑2-Aminoimidazole C3H5N31685-33-2 N-苄氧羰基-D-缬氨酸Cbz-D-Valine C13H17NO45908-81-6 钡酒石酸盐BARIUM TARTRATE C4H4BaO61700-10-3 环辛二烯1,3-CYCLOOCTADIENE C8H1250743-18-5 3-氰基-6-甲基色酮3-CYANO-6-METHYLCHROMONEC11H7NO2401-77-4 间氟三氯苄3-FLUOROBENZOTRICHLORIDE C7H4Cl3F 108957-20-6 N-BOC-3-碘-L-丙氨酸苄酯N-BOC-3-IODO-L-ALANINE BENZYL ESTER C15H20INO468121-46-0 3,5-二氯茴香硫醚3,5-DICHLOROTHIOANISOLE C7H6Cl2S 1120-97-4 4-甲基-1,3-二氧六环4-METHYL-1,3-DIOXANE C5H10O2 29973-13-5 乙硫苯威ETHIOFENCARB C11H15NO2S45644-21-1 2-氨基-6-氯吡啶2-Amino-6-chloropyridine C5H5ClN290-22-2 戊沙溴铵Valethamate bromide C19H32BrNO2136725-53-6 3-(S)-氟吡咯烷(HCL) (R)-(-)-3-FLUOROPYRROLIDINE HYDROCHLORIDE C4H9ClFN54903-50-3 4,5,6,7-四氢噻吩并[3.2-c]吡啶4,5,6,7-Tetrahydrothieno[3,2-c]pyridine C7H9NS537-47-3 4-苯基氨基脲4-PHENYLSEMICARBAZIDE C7H9N3O50847-11-5 异丁司特Ibudilast C14H18N2O30924-93-7 N-叔丁氧羰基-L-谷氨酸1-苄酯Boc-L-Glutamic acid 1-benzyl ester C17H23NO612037-01-3 氧化铽Tetraterbium heptaoxide O7Tb4-236476-78-5 3-吖丁啶羧酸3-Azetidinecarboxylic acid C4H7NO26188-23-4 6-溴-咪唑并[1,2-a]吡啶6-Bromoimidazo[1,2-a]pyridineC7H5BrN2119-28-8 1-萘胺-7-磺酸1-Naphthylamine-7-sulfonic acid C10H9NO3S 24120-18-1 BIS(1H,1H-PERFLUOROOCTYL)FUMARATE C20H6F30O4 112-84-5 芥酸酰胺cis-13-Docosenoamide C22H43NO140462-76-6 (Z)-11-[3-(二甲基氨基)亚丙基]-6,11-二氢二苯并[b,e]氧杂卓-2-乙酸盐酸盐Olopatadine hydrochloride C21H24ClNO329097-12-9 1-乙基-1,2-二氢-6-羟基-4-甲基-2-氧代-3-吡啶甲酰胺1-Ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridinecarboxamideC9H12N2O3273-09-6 苯并呋喃BENZOFURAZAN C6H4N2O655-07-2 2,4-二硝基三氟甲氧基苯2,4-Dinitro-1-(trifluoromethoxy)benzene C7H3F3N2O533429-83-3 3',5,7-三羟基-3,4'-二甲氧基黄酮3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE C17H14O72516-34-9 环丁基胺Cyclobutylamine C4H9N117482-84-5 3-氯-4-氟苯腈3-Chloro-4-fluorobenzonitrile C7H3ClFN 1844-01-5 4,4'-二苯亚甲基双酚4,4'-DihydroxytetraphenylmethaneC25H20O23344-18-1 柠檬酸镁Trimagnesium dicitrate C12H10Mg3O14648-53-3 2-甲基联苯2-METHYLBIPHENYL C13H125061-21-2 2-溴-gamma-丁内酯2-Bromo-4-butanolide C4H5BrO2 195447-80-4 4-氟-2-(三氟甲基)苯乙酸4-FLUORO-3-(TRIFLUOROMETHYL)PHENYLACETIC ACID C9H6F4O2123-35-3 月桂烯Myrcene C10H1613195-64-7 丙二酸二异丙酯Diisopropyl malonate C9H16O4580-22-3 2-氨基喹啉Quinolin-2-amine C9H8N2138977-28-3 CAPSAZEPINE C19H21ClN2O2S125643-61-0 抗氧化剂1135Octyl-3,5-di-tert-butyl-4-hydroxy-hydrocinnamate C25H42O33108-24-5 全氟辛酸乙酯ETHYL PERFLUOROOCTANOATEC10H5F15O27787-58-8 溴化铋BISMUTH(III) BROMIDE BiBr334598-49-7 5-溴茚酮5-Bromoindanone C9H7BrO2991-28-8 2,5-二氟苯甲酸2,5-Difluorobenzoic acid C7H4F2O264506-49-6 索法酮Sofalcone C27H30O630992-29-1 N-叔丁氧羰基-2-甲基丙氨酸BOC-alpha-MethylalanineC9H17NO45153-25-3 尼泊金辛酯2-Ethylhexyl 4-hydroxybenzoate C15H22O3447-31-4 2-氯-2-苯基苯乙酮DESYL CHLORIDE C14H11ClO86-47-5 7-氯-4-羟基喹啉-3-羧酸7-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID C10H6ClNO3327-62-8 丙酸钾PROPIONIC ACID POTASSIUM SALT C3H5KO2531-67-9 2,2-BIPIPERIDINE C10H20N213194-48-4 灭克磷Mocap C8H19O2PS21461-15-0 钙黄绿素Fluorexon C30H26N2O1119509-11-6 1-甲基-3-苯基哌嗪1-METHYL-3-PHENYLPIPERAZINEC11H16N27698-05-7 氘代盐酸DEUTERIUM CHLORIDE ClD5382-16-1 4-羟基哌啶4-Hydroxypiperidine C5H11NO6148-64-7 丙二酸单乙酯钾盐Ethyl potassium malonate C5H7KO42845-78-5 3-氨基-4-溴-5-苯基吡唑4-BROMO-3-PHENYL-1H-PYRAZOL-5-AMINE C9H8BrN3261723-26-6 5-氯-2-氟苄胺5-CHLORO-2-FLUOROBENZYLAMINEC7H7ClFN175205-84-23-(CHLOROMETHYL)-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZ OLE C10H6ClF3N2O202865-82-5 3-溴-4-氟-苯丙酮3'-BROMO-4'-FLUOROPROPIOPHENONE C9H8BrFO1715-33-9 泼尼松龙琥珀酸钠Prednisolone sodium succinateC46H60Na2O14164470-64-8 4-(FMOC-AMINOMETHYL)BENZOIC ACID C23H19NO4 3524-73-0 5-甲基-1-己烯5-METHYL-1-HEXENE C7H1424806-57-3 DIMETHYLPHENACYLSULFONIUM TETRAFLUOROBORATE C10H13BF4OS5330-98-3 2-氯-3-硝基噻酚2-CHLORO-3-NITROTHIOPHENEC4H2ClNO2S20780-76-1 5-碘吲哚醌5-IODOISATIN C8H4INO25580-80-3 2,3,4,5-四氟苯胺2,3,4,5-Tetrafluoroaniline C6H3F4N50-73-7 2,3,5-三氯苯甲酸2,3,5-Trichlorobenzoic acid C7H3Cl3O2 89415-43-0 4-氨基苯硼酸4-Aminophenylboronic acid C6H8BNO2 29865-90-5 3,4-二甲氧基-5-羟基苯甲醛3,4-Dimethoxy-5-hydroxybenzaldehyde C9H10O4673-84-7 2,6-二甲基-2,4,6-辛三烯2,6-DIMETHYL-2,4,6-OCTATRIENEC10H162044-56-6 十二烷基硫酸锂LITHIUM DODECYL SULFATEC12H25LiO4S79561-82-3 Boc-D-4-溴苯丙氨酸(R)-N-BOC-4-BromophenylalanineC14H18BrNO42392-39-4 地塞米松磷酸钠Dexamethasone 21-phosphate disodium salt C22H28FNa2O8P147762-53-6 Fmoc-O-磷酸基-L-酪氨酸Fmoc-O-Phospho-L-tyrosineC24H22NO8P19064-64-3 3,6-二氯-4-甲基哒嗪3,6-Dichloro-4-methylpyridazineC5H4Cl2N2678-77-3 氯化六氟戊二酸HEXAFLUOROGLUTARYL CHLORIDEC5Cl2F6O22822-41-5 2,3,4-三氟苯酚2,3,4-TRIFLUOROPHENOL C6H3F3O 24484-22-8 5-(4'-氟苯基)戊酸5-(4-FLUOROPHENYL)VALERIC ACIDC11H13FO2624-51-1 3-羟基壬烷3-NONANOL C9H20O20651-71-2 4-丁基苯甲酸4-Butylbenzoic acid C11H14O25736-88-9 4-丁氧基苯甲醛4-N-BUTOXYBENZALDEHYDE C11H14O2 123-32-0 2,5-二甲基吡嗪2,5-Dimethyl pyrazine C6H8N2768-32-1 三甲基苯硅烷PHENYLTRIMETHYLSILANE C9H14Si377-93-5 1,2-二氯四氟环丁-1-烯1,2-DICHLOROTETRAFLUOROCYCLOBUT-1-ENE C4Cl2F478537-14-1 O-叔丁基-D-丝氨酸甲酯盐酸盐O-tert-Butyl-D-serine methyl ester hydrochloride C8H18ClNO3607-81-8 苄基丙二酸二乙酯Diethyl benzylmalonate C14H18O436255-44-4 1-溴-3,3-二甲氧基丙烷3-BROMOPROPIONALDEHYDE DIMETHYL ACETAL C5H11BrO257-85-2 丙酸睾丸素Testosterone propionate C22H32O3155-04-4 2-巯基苯并噻唑锌盐Zinc 2-mercaptobenzothiazoleC14H8N2S4Zn121124-97-8 3-甲酰基-4-甲氧基苯硼酸3-Formyl-4-methoxyphenylboronic acid C8H9BO41571-30-8 8-羟基喹啉-2-羧酸8-HYDROXYQUINOLINE-2-CARBOXYLIC ACID C10H7NO31121-60-4 吡啶-2-甲醛2-Pyridinecarboxaldehyde C6H5NO25185-95-9 2,6-二氯苯甲醛肟2,6-Dichlorobenzaldoxime C7H5Cl2NO1747-60-0 2-氨基-6-甲氧基苯并噻唑2-Amino-6-methoxybenzothiazoleC8H8N2OS645-12-5 5-硝基-2-糠酸5-Nitro-2-furoic acid C5H3NO5220298-96-4 4-氨甲基-N-Boc-苯胺tert-ButylN-[4-(aminomethyl)phenyl]carbamate C12H18N2O2815-17-8 三甲基丙酮酸3,3-Dimethyl-2-oxobutyric acid C6H10O31610-39-5 十二氢苯并菲Dodecahydrotriphenylene C18H24400-93-1 4'-氟-3'-硝基苯乙酮4'-Fluoro-3'-nitroacetophenone C8H6FNO3 16982-21-1 硫代草氨酸乙酯Ethyl thiooxamate C4H7NO2S207974-14-9 4-溴-2,5-二氟苯磺酰氯4-BROMO-2,5-DIFLUOROBENZENESULFONYL CHLORIDEC6H2BrClF2O2S22948-06-7 4-三甲基苯胺N-(TRIPHENYLMETHYL)ANILINE C25H21N 7473-98-5 2-羟基-2-甲基-1-苯基-1-丙酮2-Hydroxy-2-methylpropiophenone C10H12O2209919-30-2 4-氯-2-甲基苯硼酸4-CHLORO-2-METHYLPHENYLBORONIC ACID C7H8BClO281925-81-7 5-甲基-2-庚烯-4-酮5-METHYL-2-HEPTEN-4-ONE C8H14O 24517-64-4 2-氨基-3-氰基吡啶2-Amino-3-cyanopyridine C6H5N31998-66-9 4-BROMO-2,3,5,6-TETRAFLUOROANILINE C6H2BrF4N775-06-4 DL-间酪氨酸3-(3-Hydroxyphenyl)-DL-alanine C9H11NO3553-17-3 愈创木酚碳酸酯Guaiacol carbonate C8H8O417136-36-6 N-苄基甘氨酸N-Benzylglycine C9H11NO22524-03-0 二甲基硫代磷酰氯Dimethyl chlorothiophosphateC2H6ClO2PS584-20-3 3-氨基-4,4,4-三氟丁酸3-AMINO-4,4,4-TRIFLUOROBUTYRIC ACID C4H6F3NO2117872-75-0 芴甲氧羰基-O-苄基-L-苏氨酸Fmoc-THr(Bzl)-OHC26H25NO528711-29-7 1,2,4-TRIAZOLE-1-ACETIC ACID C4H5N3O294569-84-3 2-溴-5-氟苯甲醛2-Bromo-5-fluorobenzaldehyde C7H4BrFO 117-34-0 2,2-二苯基乙酸2,2-Diphenylacetic acid C14H12O270627-17-7 4-[(2,4-DICHLOROBENZYL)OXY]BENZALDEHYDEC14H10Cl2O254512-75-3 1-溴-5-氯戊烷1-Bromo-5-chloropentane C5H10BrCl5376-10-3 1-苯并噻吩-5-基异氰酸酯(1-BENZYL-1H-IMIDAZOL-2-YL)METHANOL C11H12N2O6287-20-3 2,3-DIHYDROXYQUINOXALINE C8H6N2O214925-10-1 2-(甲基氨)三氟甲苯2-(METHYLAMINO)BENZOTRIFLUORIDE C8H8F3N149-91-7 没食子酸Gallic acid C7H6O579538-20-8 3,5-二氟苄醇3,5-Difluorobenzyl alcohol C7H6F2O460-40-2 3,3,3-三氟丙醛3,3,3-Trifluoropropanal C3H3F3O143979-15-1 Boc-L-烯丙基甘氨酸二环己胺盐Boc-L-2-allylglycinedicyclohexylamine salt C22H40N2O479-36-7 二氯乙酰氯Dichloroacetyl chloride C2HCl3O5676-58-4 2,5-二甲基苯并恶唑2,5-Dimethylbenzoxazole C9H9NO 82500-35-4 1-(四羟基糠基)哌嗪1-TETRAHYDROFURFURYL-PIPERAZINE C9H18N2O18194-24-6 二肉豆蔻酰磷脂酰胆碱（DMPC）1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE C36H72NO8P 1999-45-7 DL-ALANYL-DL-PHENYLALANINE C12H16N2O318759-96-1 3-氨基-N-甲基苄胺3-Aminobenzylmethylamine C8H12N2 123333-55-1 4,4'-联吡啶水合物4,4'-Dipyridyl hydrate C10H10N2O 175203-08-4 4-(4-CHLOROPHENYL)PYRIMIDINE-2-THIOLC10H7ClN2S95-11-4 2-氰基-5-降冰片烯5-Norbornene-2-carbonitrile C8H9N1528-74-1 4,4-二硝基联苯4,4'-DINITROBIPHENYL C12H8N2O41131-01-7 2,6-二甲基氯代乙酰苯胺2-Chloro-N-(2,6-dimethylphenyl)acetamide C10H12ClNO745784-12-7 喹啉-2-硼酸2-Quinolinylboronic acid C9H8BNO261924-25-2 3-甲基苄基异氰酸酯3-METHYLBENZYL ISOCYANATEC9H9NO80-08-0 4,4'-二氨基二苯砜4,4'-Diaminodiphenylsulfone C12H12N2O2S 216431-85-5 3-氰基-6-三氟甲基吡啶6-(Trifluoromethyl)nicotinonitrileC7H3F3N2120014-06-4 1-苄基-4-[(5,6-二甲氧基茚满酮-2-基)甲基]哌啶2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-oneC24H29NO359-43-8 维生素B1 Thiamine chloride C12H17ClN4OS1196-69-6 5-吲哚甲醛Indole-5-carboxaldehyde C9H7NO877-42-9 6-溴-2-甲基喹啉6-Bromo-2-methylquinoline C10H8BrN 24032-84-6 4-三氟甲基硫代苯基异氰酸酯4-(TRIFLUOROMETHYLTHIO)PHENYL ISOCYANATE C8H4F3NOS488-43-7 D-萄糖胺D-GLUCAMINE C6H15NO51611-07-0 3,5-二-叔-丁基-4-羟基苯乙腈3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLACETONITRILE C16H23NO 39212-23-2 威士忌内酯Whiskey lactone C9H16O22699-79-8 硫酰氟SULFURYL FLUORIDE F2O2S190190-50-2 BOC-(R)-3-氨基-4,4-二苯基-丁酸BOC-(R)-3-AMINO-4,4-DIPHENYL-BUTYRIC ACID C21H25NO44837-19-8 3-(二氟甲氧基)苯甲酸3-(DIFLUOROMETHOXY)BENZOIC ACID C8H6F2O324589-78-4 N-甲基-N-(三甲基硅烷基)三氟乙酰胺N-Methyl-N-(trimethylsilyl)trifluoroacetamide C6H12F3NOSi3326-32-7 异硫氰酸荧光素酯Fluorescein isothiocyanate isomer IC21H11NO5S532-11-6 茴三硫Anethole trithione C10H8OS31676-75-1 N-苄氧羰基-O-叔丁基-L-丝氨酸N-Cbz-O-tert-butyl-L-serineC15H21NO52065-23-8 苯氧乙酸甲酯Methyl phenoxyacetate C9H10O36027-21-0 D-高丝氨酸D-Homoserine C4H9NO3243666-11-7 2-甲基-6-三氟甲基吡啶-3-羰酰氯4-AMINO-7-(TRIFLUOROMETHYL)QUINOLINE C10H7F3N266609-04-9 异硫代氰2-乙基-6-甲基苯基酸酯2-ETHYL-6-METHYLPHENYL ISOTHIOCYANATE C10H11NS14533-63-2 丙烷磺酸钠Sodium 1-propanesulfonate C3H7NaO3S5292-42-2 2,3,4,5-四氟苯甲酸甲酯2,3,4,5-TETRAFLUORO-BENZOIC ACID METHYL ESTER C8H4F4O2551-08-6 3-正丁烯基苯酞N-BUTYLIDENEPHTHALIDE C12H12O2104-29-0 氯苯甘醚Chlorphenesin C9H11ClO3408-50-4 4-溴-3-氟苯甲醚4-Bromo-3-fluoroanisole C7H6BrFO1577-22-6 5-己烯酸5-HEXENOIC ACID C6H10O21080-44-0 N-对甲苯磺酰甘氨酸N-P-TOSYLGLYCINE C9H11NO4S 32222-06-3 钙三醇1alpha,25-Dihydroxycholecalciferol C27H44O3 80154-34-3 豆腐果苷Helicid C13H16O7381721-55-7 1-(2-IMIDAZOL-1-YL-ETHYL)-PIPERAZINE C9H16N4 65355-30-8 反式-4-戊基环己基苯甲酸4-(trans-4-Pentylcyclohexyl)benzoic acid C18H26O262936-23-6 5-氯香草酸5-CHLOROVANILLIC ACID C8H7ClO423743-26-2 1,2-双(二环己基磷基)-乙烷1,2-BIS(DICYCLOHEXYLPHOSPHINO)ETHANE C26H48P2670-80-4 1-吗啉基-1-环己烯N-(1-Cyclohexen-1-yl)morpholineC10H17NO552-86-3 糠偶因2,2'-Furoin C10H8O413515-97-4 DL-丙氨酸甲酯盐酸盐Methyl DL-2-aminopropanoate hydrochloride C4H10ClNO284806-27-9 7-苯并呋咱-4-磺酸铵7-FLUOROBENZO-2-OXA-1,3-DIAZOLE-4-SULFONIC ACID AMMONIUM SALT C6H6FN3O4S119192-10-8 4-(1H-1,2,4-三氮唑-1-基甲基)苯胺4-(1H-1,2,4-Triazol-1-ylmethyl)aniline C9H10N43430-18-0 2,5-二溴-3-甲基吡啶2,5-Dibromo-3-methylpyridine C6H5Br2N 71581-92-5 顺-(1R,2S)-(+)-苄胺环己烷甲醇(+)-CIS-2-BENZYLAMINOCYCLOHEXANEMETHANOL C14H21NO15952-70-2 2,4-二氟-3,5-二氯硝基苯2,4-Difluoro-3,5-dichloronitrobenzene C6HCl2F2NO2261762-45-2 2-氯-3,6-二氟苄胺2-CHLORO-3,6-DIFLUOROBENZYLAMINE C7H6ClF2N1501-06-0 乙酰戊二酸二乙酯DIETHYL 2-ACETYLGLUTARATEC11H18O51121-31-9 2-巯基吡啶-N-氧化物2-Pyridinethiol 1-oxide C5H5NOS32737-14-7 2-乙氧基-3-甲基吡嗪2-Ethoxy-3-methylpyrazine C7H10N2O 43064-12-6 4-苯基-1,2,3,6-四氢吡啶盐酸盐4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride C11H14ClN56-06-4 2,4-二氨基-6-羟基嘧啶2,4-Diamino-6-hydroxypyrimidineC4H6N4O95-89-6 3-氯-2,5-二甲基吡嗪3-CHLORO-2,5-DIMETHYLPYRAZINEC6H7ClN214273-86-0 5-氯戊酸甲酯Methyl 5-chloropentanoate C6H11ClO2 141179-72-8 4-氟-2-(三氟甲基)苯甲酸4-FLUORO-2-(TRIFLUOROMETHYL)BENZOIC ACID C8H4F4O22493-02-9 4-溴异氰酸苯酯4-BROMOPHENYL ISOCYANATEC7H4BrNO500912-12-9 2-氟-6-甲氧基苄氯2-Fluoro-6-methoxybenzoyl chloridC8H6ClFO239835-14-8 2-HYDROXY-4-NITROBENZONITRILE C7H4N2O32365-48-2 巯基乙酸甲酯Methyl thioglycolate C3H6O2S142-31-4 辛基硫酸钠Sodium octyl sulfate C8H17NaO4S52509-14-5 (1,3-二氧戊环-2-基)甲基三苯基溴化瞵(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide C22H22BrO2P 1665-48-1 美他沙酮Metaxalone C12H15NO313450-92-5 溴化锗GERMANIUM TETRABROMIDE Br4Ge45102-52-1 2,2,3,3-四氟丙基甲基丙烯酸酯2,2,3,3-Tetrafluoropropyl methacrylate C7H8F4O235854-86-5 (Z)-6-壬烯-1-醇cis-6-Nonen-1-ol C9H18O145038-50-2 Fmoc-L-谷氨酸gamma-甲酯Fmoc-L-Glutamic acid gamma-methyl ester C21H21NO61459-10-5 十四烷基苯TETRADECYLBENZENE C20H3420535-83-5 2-氨基-6-甲氧基嘌呤6-Methoxyguanine C6H8N5O21508-65-2 盐酸奥昔布宁Oxybutynin hydrochloride C22H32ClNO3 39267-74-8 2,5,6-三氨基-4-嘧啶醇硫酸盐6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE SULFATE C4H9N5O5S 36768-62-4 2,2,6,6-四甲基哌啶胺Triacetonediamine C9H20N2O33943-89-3 3,4-二羟基苯甲酸乙酯Ethyl 3,4-dihydroxybenzoate C9H10O4 94-74-6 2-甲基-4-氯苯氧乙酸2-Methyl-4-chlorophenoxyacetic acidC9H9ClO35989-81-1 alpha-D-乳糖单水合物ALPHA-LACTOSE MONOHYDRATEC12H24O12614-72-2 鄰氯苯基乙基醚2-CHLOROPHENETOLE C8H9ClO54406-48-3 右旋反式炔戊菊酯Empenthrin C18H25O2-155206-00-1 比马前列素Bimatoprost C25H37NO493-07-2 3,4-二甲氧基苯甲酸3,4-Dimethoxybenzoic acid C9H10O4 2437-25-4 十二腈Dodecanenitrile C12H23N50262-48-1 4-丙烯氧基苯甲醛4-PROPIONYLOXYBENZALDEHYDEC10H10O3。

取代芳硼酸

取代芳硼酸化合物从1860年首次分离得到硼酸，到1979年日本化学家Suzuki和Miyarua的催化作用下成功利用芳基硼酸与卤代芳烃交叉偶联这个期间，关于硼酸及其衍生物的研究进展比较缓慢。

自20世纪80年代初，美国制药公司Millennium研发出了首个作用于人体的硼酸系列抗癌药Velcade(商品名称：万珂；化学名称：[(1R)-3-甲基-1-[[(2S)-1-氧-3-苯基-2-[(吡嗪羧基)氨基]丙基]氨基]丁基]硼酸[1]，芳基硼酸在铑系催化剂的作用下与烯、醛发生偶联反应制得)以来，关于硼酸及其衍生物的文献报道便层出不穷，其研究取得了突破性进展。

取代芳硼酸及其衍生物是带有取代基的单苯环或多环芳烃的硼酸衍生物，为中等强度的路易斯酸，其在空气中较为稳定、对潮气不敏感、可以长期保存且反应活性较高，因此，取代芳硼酸及其衍生物不但是重要的有机合成中间体及医药、农药中间体，多用于制备医药、农药等活性目标化合物,而且在制备生物活性试剂或材料研究上也有广泛的应用。

由于它具有低毒性和最终降解成为对环境友好的硼酸,所以取代芳基硼酸被认为是绿色化合物。

作为重要的有机中间体, 取代芳硼酸及其衍生物广泛应用于Suzuki 交叉偶联反应、氨基酸的不对称合成、氨基化合物催化剂等，如取代邻-硝基苯硼酸（或它们的酯）参与各种杂环的合成；苯氰硼酸是取代二苯衍生物等重要活性化合物的前体；四唑苯硼酸或衍生物进一步反应可得到很多受体拮抗药的前体物[2-5]。

在生物学、医学或材料学上, 取代芳硼酸及其衍生物被用于烃类的传感器、核苷和糖类的选择性输运载体、酶的抑制剂、以及在某些脑瘤病人的硼中子俘获治疗法中用作治疗剂等[2]。

此外，N-苯基-1,8-萘二甲酰亚胺等被间氨基苯硼酸修饰后，还可制成测定糖类的传感器[6]。

对于各种取代芳环硼酸的合成研究，国外最早起于20 世纪50 年代左右，现对其合成方法进行归纳比较。

关于取代芳环硼酸化合物的合成方法主要有3种：有机锂试剂法；格氏试剂法；钯催化氧硼基化法。

镍催化芳磺酸酯与芳硼酸偶联反应的研究

镍催化芳磺酸酯与芳硼酸偶联反应的研究陈国军;李玲【摘要】研究以二甲氨基磺酰氯作为酚的活化基团,酚经该基团活化后,在NiCl2(dppp)催化下,能与各种芳硼酸发生有效的Suzuki偶联.【期刊名称】《长春工程学院学报（自然科学版）》【年(卷),期】2013(014)004【总页数】5页(P117-121)【关键词】镍;偶联;活化基团【作者】陈国军;李玲【作者单位】长春工程学院理学院,长春130012;山东石大科技集团有限公司,山东东营257061【正文语种】中文【中图分类】O621.25在现代合成化学中，过渡金属催化的偶联反应仍然起着重要作用［1］。

尽管芳基卤化物常被作为亲电试剂［2］，酚衍生物将会替代芳卤化物，主要是因为酚价格便宜且比较常见。

迄今为止，芳基三氟甲磺酸酯被研究的频率较高［3］，但成本较高且不稳定的特点限制了它的应用［4］。

价格便宜且易合成的芳基磺酸酯［5－7］、芳基醚［8］、芳基磷酸酯［9］和芳氨基磺酸酯［10－11］也是很好的亲核试剂。

这些亲核试剂比较常见，便于合成，但它们在Pd催化剂催化下并不发生偶联反应。

且这些亲核试剂在通过C—H活化和DoM反应构建芳环时具有区域选择性的优点［12－14］。

我们致力于研究酚的氨基磺酸酯和芳硼酸的偶联反应。

以前关于此类底物的偶联反应主要是镍催化的Kumada偶联反应，直到最近，才出现了关于Ni催化此类底物的Suzuki偶联的报道［15］。

但他们的研究也存在问题：（1）催化剂价格昂贵且用量太大；（2）硼酸用量大。

我们将主要从这两方面对其进行改善。

1 实验部分反应均在氮气保护条件下进行。

1，4—二氧六环通过4˚A型分子筛干燥后再进行使用；K3PO4和三乙胺买来直接使用。

无水NiCl2、二甲胺基磺酰氯及配体dppp均从百灵威科技有限公司买来后直接使用。

2 结果与讨论我们选用1—萘酚和4—甲氧基苯硼酸之间的偶联反应来优化反应条件。

图1 底物1与2间的Suzuki偶联反应NiCl2（dppp）的用量定为底物1用量的1 mol%，硼酸用量定为底物1用量的1.2倍，K3PO4用量定为底物1用量的4倍，溶剂为1，4—二氧六环（3mL），反应的温度为110℃。