EXPERIMENTAL STUDY OF INFLAMMATORY AND METASTATIC LYMPH NODES WITH DIFFUSION WEIGHTED IMAGING ON
久咳颗粒镇咳、抗炎和祛痰作用实验研究
·基础论著·久咳颗粒镇咳、抗炎和祛痰作用实验研究仇燚* 徐燕莉（泸州市中医院，四川 泸州 646000）摘要 目的：研究久咳颗粒的镇咳、抗炎和祛痰药理作用。
方法：180只ICR 小鼠（雌雄各半）根据体重随机分为正常组、模型组、阳性组以及久咳颗粒高（28 g 生药·kg -1）、中（14 g 生药·kg -1）、低（7 g 生药·kg -1）三个剂量组（n=10），预防性给药7 d 后，分别考察氨水致小鼠咳嗽模型、二甲苯致小鼠耳廓肿胀模型和气管酚红法中各模型动物的咳嗽潜伏期、咳嗽次数、耳肿胀度和酚红排泌量。
结果：与正常组比较，模型组小鼠的咳嗽的潜伏期明显缩短（P<0.01）、咳嗽次数明显增加（P<0.01），耳肿胀度明显增加（P<0.01）而酚红排泌量减少（P<0.01）；与模型组比较，久咳颗粒高中剂量组小鼠的咳嗽的潜伏期明显延长（P<0.05）、咳嗽次数明显减少（P<0.05）和耳肿胀度降低（P<0.05），且久咳颗粒各剂量组酚红排泌量明显增加（P<0.05）。
结论：久咳颗粒具有显著的镇咳、抗炎和祛痰作用。
关键词：久咳颗粒；镇咳；抗炎；祛痰Experimental study on antitussive, anti-inflammatory and expectoranteffects of Jiuke granuleQiu Yi*, Xu Yan-li(Luzhou Hospital of Traditional Chinese Medicine, Luzhou 646000, Sichuan, China)Abstract Objective: To study the antitussive, anti-inflammatory and expectorant pharmacological effects of Jiuke granules on mice. Methods: One hundred and eighty ICR mice (half male and half female) were randomlydivided into normal group, model group, positive group and high-dose (28g crude drug·kg -1), medium-dose (14g crude drug·kg -1) and low-dose (7g crude drug·kg -1) of Jiuke granule (n=10) according to the body weight. The latency of cough, cough frequency, ear swelling and phenol red excretion were measured granule by using the model of cough model induced by ammonia, xylene induced auricle swelling in mice and trachea phenol red method after they were administrated with Jiuke granule for 7 days. Results: Compared with the normal group, the incubation period of cough in the model group was significantly shorter (P<0.01), the number of coughing and the ear swelling degree was significantly increased (P<0.01), and the phenol red excretion was decreased (P<0.01). Compared with the model group, the cough latency was significantly prolonged (P<0.05), the cough frequency was significantly reduced (P<0.05) and the degree of ear swelling was decreased (P<0.05). The phenol red excretion was significantly increased in each dose group of jiuke granule (P<0.05). Conclusion: Jiuke granule has significant antitussive, anti-inflammatory and expectorant effects.Key words: Jiuke granule; Anti-tussive; Anti-inflammatory; Expectorant*作者简介：仇燚，男，主任中医师，主要从事中西医内儿科临床工作，Email ：*******************。
青刺果油皮炎凝胶抗炎止痒作用的实验研究
64云南中医中药杂志2021年第4!卷第！期青刺果油皮炎凝胶抗炎止痒作用的实验研究！曹玺，和丽生，刘因华，张娅，夏亮，李琴，陈茹(云南省中医中药研究院，云南昆明650223)摘要：目的研究青刺果油皮炎凝胶抗炎止痒作用。
方法60只雄性小鼠随机分为6组，包括模型对照组、凝胶基质对照组、复方醋酸地塞米松乳膏组和青刺果油皮炎凝胶低、中、高剂量组，采用二甲苯致小鼠耳廓肿胀实验观察其抗炎作用；60只豚鼠随机分为6组，包括模型对照组、凝胶基质对照组、糠酸莫米松凝胶组和青刺果油皮炎凝胶低、中、高剂量组，采用磷酸组织胺致豚鼠瘙痒观察其止痒作用。
结果青刺果油皮炎凝胶中、高剂量组能极显著抑制小鼠耳廓肿胀（！<0.01 #，低剂量组能显著抑制小鼠耳廓肿胀（！< 0.05#;青刺果油皮炎凝胶低、中、高剂量组肿胀抑制率分别为16. 17?、32. 30?、23. 57?。
青刺果油皮炎凝胶高剂量组有极显著增高豚鼠致痒阈作用（！<0. 01)。
结论青刺果油皮炎凝胶具有抗炎、止痒作用。
关键词！青刺果油皮炎凝胶;抗炎；止痒中图分类号：：285. 5 文献标志码:A文章编号！1007 -2349(2021)02 -0064 -03Experimental Study onAnti - inflammatory andAntipruritic Effectsof Prinsepia Utilis Royle Extract Dermatitis GelCAO X i，HE Li -sheng，LIU Y in -h u a，ZH AN G Y a，X IA L ian g，Lli Q in，CHEN Ru(Yunnan Institute of Traditional Chinese Medicine and Materia Medica，Kunming 65022，China)【A b s tr a c t】O b jective:To study the anti- inflammation and antipruritic effects of Prinsepia Utilis Royle ExtractDermatitis G el.Metliods：60 m ale mice were randomly divided into 6 groups，including model control group，gel matrix control group，compound dexametliasone acetate cream group，and lo w，m edium，and high - dose groups of Prinsepia Utilis Royle Extract Dermatitis G el.Histamine phosphate was used to induce the ear swelling in mice to observeits anti- inflammatory effect.60 guinea pigs were randomly divided into 6 groups，including m matrix control group，mometasone furoate gel group and Prinsepia Utilis Royle Extract Dermatitis Gel groups of lo w，medium and high d oses.The antipruritic effect of histamine phosphate in the guinea pigs was observed.R esults：Themedium and high-dose groups of Prinsepia Utilis Royle Extract Dermatitis Gel could very significantly inhibit the earswelling of the mice(! <0. 01 )，and the low- dose group could significantly inhibit the ea <0. 05) .The s welling inhibition rates of Prinsepia Utilis Royle Extract Dermatitis Gel of lo w，medium and high dosegroups were 16. 17?，32. 30?and 23. 57?respectively.The high- dose group of Prinsepia U Dermatitis Gel had a very significant effect on increasing the itching threshold of guinea pig Prinsepia Utilis Royle Extract Dermatitis Gel has anti - inflammatory and antipruritic effects.【K e y w o r d s】Prinsepia Utilis Royle Extract Dermatitis G e l;Anti - inflammatory;Antipruritic青刺果为蔷薇科植物总花扁核木（Prinsepia utilis炮筒果、梅花刺、打枪果、枪子果、阿那斯（纳西族），R oyle)的果实，别名青刺尖、打油果、青那果、狗奶子、出裸（彝族），生长于海拔1800〜3000m的山坡、荒!基金项目：2017年云南省应用基础一中医联合专项[2017FF117( -050)]第一作者简介:曹玺（1979 -)，女，硕士，副主任药师，研究方向:药物临床前研究。
微创拔牙与传统拔牙的临床效果比较
微创拔牙与传统拔牙的临床效果比较摘要】目的：观察比较微创拔牙与传统拔牙的临床效果。
方法：选取我院2018年3月—2019年3月收治的74例行拔牙术患者为本次研究对象，按照术式不同将所有患者分为对照组（37例：传统拔牙）与实验组（37例：微创拔牙），比较两组患者预后。
结果：实验组患者术后24h各项炎症指征以及并发症发生率（5.40%）均低于对照组，差异显著（P＜0.05）。
结论:微创拔牙术明显优于传统拔牙术。
【关键词】微创拔牙；传统拔牙；临床效果【中图分类号】R781.05 【文献标识码】A 【文章编号】2095-1752（2019）32-0016-02Comparison of clinical effects between minimally invasive tooth extraction and traditional tooth extractionGan ShengyuanLeshan People's Hospital,Leshan,Sichuan 614000, China【Abstract】Objective To observe the clinical effects of minimally invasive tooth extraction and traditional tooth extraction. Methods 74 tooth extraction patients admitted from March 2018 to March 2019 in our hospital were the subjects of this study. All patients were divided into control group (37 cases: traditional tooth extraction) and experimental group (37 cases: minimally invasive tooth extraction) according to different surgical methods, and the prognosis of the two groups was compared. Results The inflammatory signs and complication rate (5.40%) of the experimental group were better than that of the control group 24h after operation,P<0.05. Conclusion Tooth extraction is better than traditional tooth extraction.【Key words】Minimally invasive tooth extraction; Traditional tooth extraction; Clinical effect牙拔除术属于口腔科较为常见的术式，术式牙拔除术可对患者口腔软组织造成一定的损伤，近些年随着我国居民对牙齿健康的重视，畸形牙、阻生牙以及严重错位牙及时行拔牙术对改善患者口腔环境具有重要的意义[1]。
2021医学考研复试：心血管内科[SC长难句翻译文]
![2021医学考研复试：心血管内科[SC长难句翻译文]](https://img.taocdn.com/s3/m/9d3495e931b765ce050814b0.png)
木仓医学考研复试SCI长难句循环内科第一章—二尖瓣返流Ischemic mitral regurgitation(IMR)is a frequent complication of left ventricular(LV)global or regional pathological remodeling due to chronic coronary artery disease.It is not a valve disease but represents the valvular consequences of increased tethering forces and reduced closing forces.IMR is defined as mitral regurgitation caused by chronic changes of LV structure and function due to ischemic heart disease and it worsens the prognosis.缺血性二尖瓣返流(IMR)是慢性冠脉疾病引起的左心室(LV)整体或局部病理性重塑的常见并发症。
它不是一种瓣膜病，但它表现了系留力增加和关闭力减少所导致的瓣膜症状。
IMR的定义为由缺血性心脏病引起的左室结构和功能的慢性改变所导致的二尖瓣返流，使患者的预后更差。
知识点总结：①ischemic adj.缺血性的，局部缺血的②mitral adj.二尖瓣的③regurgitation n.回流，返流④ventricular n.心室/adj.心室的⑤pathological adj.病理的⑥remodeling n.重塑，重建⑦coronary artery冠状动脉⑧valve/valvular n.瓣膜/adj.瓣膜的⑨tether v.系，拴住⑩prognosis n.预后木仓医学考研复试SCI长难句循环内科第二章—急性心力衰竭A diagnosis of acute heart failure（AHF）is made when patients present acutely with signs and symptoms of heart failure,often with decompensation of pre-existing cardiomyopathy.The most current guidelines classify based on clinical features at initial presentation and are used to both risk stratify and guide the management of haemodynamic compromise.Despite this,AHF remains a diagnosis with a poor prognosis and there is no therapy proven to have long-term mortality benefits.急性心力衰竭(AHF)的诊断是基于患者突然表现出心力衰竭的体征和症状，通常伴有原有心肌病的失代偿。
肺功能检查在博来霉素诱导的大鼠肺纤维化中的实验研究
医学＊［基金项目］内蒙古自治区人民医院院内基金（编号：２０１６０９６）△［通讯作者］Ｅ－ｍａｉｌ：７７５４５３６９７＠ｑｑ．ｃｏｍＤＯＩ：１０．１６０９６／Ｊ．ｃｎｋｉ．ｎｍｇｙｘｚｚ．２０２０．５２．１１．００４肺功能检查在博来霉素诱导的大鼠肺纤维化中的实验研究＊高 丽１，董 润２△（１．内蒙古自治区人民医院呼吸与危重症医学科，内蒙古呼和浩特 ０１００１７；２．郑州市中心医院呼吸与危重症医学科，河南郑州 ４５００００）［摘要］目的 由于条件限制，在许多大鼠疾病模型中无法检测肺功能的变化情况，检测肺纤维化大鼠的肺功能对实验动物的肺功能应用具有重要意义。
方法 １２只健康ＳＤ大鼠，随机分成正常对照组和博来霉素组，气管注射博来霉素（５ ｍｇ／ｋｇ）复制大鼠肺纤维化模型。
于第２８日腹主动脉放血法处死，比较两组体质量及肺质量，计算肺系数，检测两组大鼠肺功能和肺组织中羟脯氨酸的含量。
结果 与正常对照组比较，博来霉素组大鼠肺系数明显升高，博来霉素组羟脯氨酸的含量明显升高，同时ＨＥ和ＭＡＳＳＯＮ病理染色提示大鼠肺纤维化模型复制成功。
大鼠肺功能检查结果：用力肺活量（ｆｏｒｃｅｄ ｖｉｔａｌ ｃａｐａｃｉｔｙ，ＦＶＣ）、５０％肺活量的呼气流速（ｆｏｒｃｅｄ ｅｘｐｉｒａｔｏｒｙ ｆｌｏｗ，ＦＥＦ）、最大呼气流量（ｐｅａｋ ｅｘｐｉｒａｔｏｒｙ ｆｌｏｗ，ＰＥＦ）均较正常对照组明显降低，且具有统计学意义，另外，博来霉素组ＦＥＶ０．１／ＦＶＣ较正常对照组升高。
结论 大鼠肺纤维化模型中肺功能检测技术基本成熟，可以进一步扩大样本量进行研究。
［关键词］大鼠肺纤维化；博来霉素；肺功能；肺系数 ［中图分类号］Ｒ５６３ ［文献标识码］Ａ ［论文编号］１００４－０９５１（２０２０）１１－１２９１－０３Ｅｘｐｅｒｉｍｅｎｔａｌ Ｓｔｕｄｙ ｏｆ Ｌｕｎｇ Ｆｕｎｃｔｉｏｎ Ｔｅｓｔ ｉｎ Ｂｌｅｏｍｙｃｉｎ－ｉｎｄｕｃｅｄＰｕｌｍｏｎａｒｙ Ｆｉｂｒｏｓｉｓ ｉｎ Ｒａｔｓ＊ＧＡＯ Ｌｉ １，ＤＯＮＧ Ｙｕｎ２△（１．Ｄｅｐａｒｔｍｅｎｔ ｏｆ Ｒｅｓｐｉｒａｔｏｒｙ ａｎｄ Ｃｒｉｔｉｃａｌ Ｃａｒｅ Ｍｅｄｉｃｉｎｅ，Ｐｅｏｐｌｅ＇ｓ Ｈｏｓｐｉｔａｌ ｏｆ Ｉｎｎｅｒ ＭｏｎｇｏｌｉａＡｕｔｏｎｏｍｏｕｓ Ｒｅｇｉｏｎ，Ｈｏｈｈｏｔ ０１００１７ Ｃｈｉｎａ；２．Ｚｈｅｎｇｚｈｏｕ Ｃｅｎｔｒａｌ Ｈｏｓｐｉｔａｌ，Ｄｅｐａｒｔｍｅｎｔ ｏｆＲｅｓｐｉｒａｔｏｒｙ ａｎｄ Ｃｒｉｔｉｃａｌ Ｃａｒｅ ＭｅｄｉｃｉｎｅＡｂｓｔｒａｃｔ，Ｚｅｎｇｚｈｏｕ４５００００ Ｃｈｉｎａ）［Ａｂｓｔｒａｃｔ］Ｏｂｊｅｃｔｉｖｅ Ｂｅｃａｕｓｅ ｏｆ ｔｈｅ ｌｉｍｉｔａｔｉｏｎ ｏｆ ｃｏｎｄｉｔｉｏｎｓ；ｉｔ ｉｓ ｉｍｐｏｓｓｉｂｌｅ ｔｏ ｄｅｔｅｃｔ ｔｈｅ ｃｈａｎｇｅｓ ｏｆｐｕｌｍｏｎａｒｙ ｆｕｎｃｔｉｏｎ ｉｎ ｍａｎｙ ｒａｔ ｄｉｓｅａｓｅ ｍｏｄｅｌｓ．Ｄｅｔｅｃｔｉｏｎ ｏｆ ｐｕｌｍｏｎａｒｙ ｆｕｎｃｔｉｏｎ ｉｎ ｒａｔｓ ｗｉｔｈ ｐｕｌｍｏｎａｒｙ ｆｉ－ｂｒｏｓｉｓ ｉｓ ｏｆ ｇｒｅａｔ ｓｉｇｎｉｆｉｃａｎｃｅ ｔｏ ｓｃｉｅｎｔｉｆｉｃ ｒｅｓｅａｒｃｈ ａｎｄ ｃｌｉｎｉｃａｌ ｐｒｅｖｅｎｔｉｏｎ ａｎｄ ｔｒｅａｔｍｅｎｔ ｏｆ ｐｕｌｍｏｎａｒｙ ｆｉｂｒｏ－ｓｉｓ．Ｍｅｔｈｏｄｓ Ｈｅａｌｔｈｙ ＳＤ ｒａｔｓ ｗｅｒｅ ｒａｎｄｏｍｌｙ ｇｒｏｕｐｅｄ ａｃｃｏｒｄｉｎｇ ｔｏ ｒａｎｄｏｍ ｎｕｍｂｅｒ ｔａｂｌｅ．Ｒａｔｓ ｗｅｒｅ ｉｎ－ｄｕｃｅｄ ｐｕｌｍｏｎａｒｙ ｆｉｂｒｏｓｉｓ ｂｙ ｉｎｔｒａｔｒａｃｈｅａｌ ｉｎｊｅｃｔｉｏｎ ｏｆ ｂｌｅｏｍｙｃｉｎ．Ｔｈｅ ｒａｔｓ ｗｉｔｈ ｐｕｌｍｏｎａｒｙ ｆｉｂｒｏｓｉｓ ｗｅｒｅｒａｎｄｏｍｌｙ ｄｉｖｉｄｅｄ ｉｎｔｏ ｔｗｏ ｇｒｏｕｐｓ：ｃｏｎｔｒｏｌ ｇｒｏｕｐ，ｎａｍｅｌｙ ｒａｔｓ ｒｅｃｅｉｖｉｎｇ ｉｎｔｒａｔｒａｃｈｅａｌ ｉｎｊｅｃｔｉｏｎ ｏｆ ｓａｌｉｎｅ；ｍｏｄｅｌ ｇｒｏｕｐ，ｎａｍｅｌｙ ｒａｔｓ ｒｅｃｅｉｖｉｎｇ ｉｎｔｒａｔｒａｃｈｅａｌ ｉｎｊｅｃｔｉｏｎ ｏｆ ＢＬＭ；Ｂｙ ａｎａｌｙｚｉｎｇ ｔｈｅ ｇｅｎｅｒａｌ ｃｏｎｄｉｔｉｏｎｓ ｏｆｔｈｅ ｒａｔｓ，ｌｕｎｇ ｃｏｅｆｆｉｃｉｅｎｔｓ ｗｅｒｅ ｃａｌｃｕｌａｔｅｄ，ａｎｄ ｌｕｎｇ ｆｕｎｃｔｉｏｎｓ ｏｆ ｔｈｅ ｒａｔｓ ｉｎ ｅａｃｈ ｇｒｏｕｐ ｗｅｒｅ ｅｘａｍｉｎｅｄ．Ｔｈｅ Ｈ＆Ｅ ａｎｄ Ｍａｓｏｎ＇ｓ ｓｔａｉｎｉｎｇ ｗｅｒｅ ｐｅｒｆｏｒｍｅｄ ｔｏ ｅｖａｌｕａｔｅ ｐｕｌｍｏｎａｒｙ ｆｉｂｒｏｓｉｓ ｉｎｊｕｒｙ，ｉｎｆｌａｍｍａｔｏｒｙ ｃｅｌｌｉｎｆｉｌｔｒａｔｉｏｎ，ｓｔｒｕｃｔｕｒａｌ ｄｉｓｏｒｄｅｒ ａｎｄ ｃｏｌｌａｇｅｎ ｄｅｐｏｓｉｔｉｏｎ．Ｔｈｅ ｃｏｎｔｅｎｔｓ ｏｆ Ｈｙｄｒｏｘｙｐｒｏｌｉｎｅ ｗａｓ ｄｅｔｅｒｍｉｎｅｄｂｙ ｂｉｏｃｈｅｍｉｃａｌ ｋｉｔｓ．Ｒｅｓｕｌｔｓ ＢＬＭ－ｔｒｅａｔｅｄ ｒａｔｓ ｅｘｈｉｂｉｔｅｄ ｔｙｐｉｃａｌ ｓｙｍｐｔｏｍｓ ｏｆ ｐｕｌｍｏｎａｒｙ ｆｉｂｒｏｓｉｓ，ｆｅａ－ｔｕｒｅｄ ａｓ ｉｎｃｒｅａｓｅｄ ｃｏｌｌａｇｅｎ ｄｅｐｏｓｉｔｉｏｎ ａｎｄ ａｌｖｅｏｌｉｔｉｓ，ａｎｄ ｆｉｂｒｏｓｉｓ ａｎｄ ｔｈｅ ｐａｒｅｎｃｈｙｍａｌ ｓｔｒｕｃｔｕｒａｌ ｄｉｓｏｒｄｅｒ ｉｎｔｈｅ ｌｕｎｇ．Ｃｏｍｐａｒｅｄ ｗｉｔｈ ｔｈｅ ｂｌｅｏｍｙｃｉｎ ｇｒｏｕｐ，ｔｈｅ ｌｕｎｇ ｃｏｅｆｆｉｃｉｅｎｔ，ｌｕｎｇ ｆｕｎｃｔｉｏｎ ａｎｄ ｈｙｄｒｏｘｙｐｒｏｌｉｎｅ ｉｎｔｈｅ ｈｙｄｒｏｇｅｎ ｉｎｈａｌａｔｉｏｎ ｉｎｔｅｒｖｅｎｔｉｏｎ ｇｒｏｕｐ ｗｅｒｅ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｒｅｄｕｃｅｄ，ｗｉｔｈ ｓｔａｔｉｓｔｉｃａｌ ｄｉｆｆｅｒｅｎｃｅｓ．Ｔｈｅ ｒｅ－１９２１内蒙古医学杂志Ｉｎｎｅｒ Ｍｏｎｇｏｌｉａ Ｍｅｄ Ｊ ２０２０年第５２卷第１１期ｓｕｌｔｓ ｏｆ ｐｕｌｍｏｎａｒｙ ｆｕｎｃｔｉｏｎ ｔｅｓｔ ｉｎ ｒａｔｓ ｗｅｒｅ ａｓ ｆｏｌｌｏｗｓ：ＦＶＣ（ｆｏｒｃｅｄ ｖｉｔａｌ ｃａｐａｃｉｔｙ）、５０％ＦＥＦ（ｆｏｒｃｅｄ ｅｘ－ｐｉｒａｔｏｒｙ ｆｌｏｗ）、ＰＥＦ（ｐｅａｋ ｅｘｐｉｒａｔｏｒｙ ｆｌｏｗ）ｗｅｒｅ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｌｏｗｅｒ ｔｈａｎ ｔｈｏｓｅ ｉｎ ｔｈｅ ｎｏｒｍａｌ ｃｏｎｔｒｏｌ ｇｒｏｕｐ．Ａｎｄ ｉｔ ｈａｓ ｓｔａｔｉｓｔｉｃａｌ ｓｉｇｎｉｆｉｃａｎｃｅ．Ｃｏｎｃｌｕｓｉｏｎｓ Ｔｈｅ ｐｕｌｍｏｎａｒｙ ｆｕｎｃｔｉｏｎ ｄｅｔｅｃｔｉｏｎ ｔｅｃｈｎｏｌｏｇｙ ｉｎ ｒａｔ ｐｕｌｍｏ－ｎａｒｙ ｆｉｂｒｏｓｉｓ ｍｏｄｅｌ ｉｓ ｍａｔｕｒｅ，ｗｈｉｃｈ ｃａｎ ｆｕｒｔｈｅｒ ｅｘｐａｎｄ ｔｈｅ ｓａｍｐｌｅ ｓｉｚｅ ｆｏｒ ｒｅｓｅａｒｃｈ．［Ｋｅｙ ｗｏｒｄｓ］ｐｕｌｍｏｎａｒｙ ｆｉｂｒｏｓｉｓ；ｂｌｅｏｍｙｃｉｎ；ｐｕｌｍｏｎａｒｙ ｆｕｎｃｔｉｏｎ；ｌｕｎｇ ｃｏｅｆｆｉｃｉｅｎｔｓ 由于条件限制，在许多大鼠疾病模型中无法检测肺功能的变化情况。
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时珍国医国药２００９年第２０卷第１１期ＬＩＳＨＩＺＨＥＮＭＥＤＩＣＩＮＥＡＮＤＭＡＴＥＲＩＡＭＥＤＩＣＡＲＥＳＥＡＲＣＨ２００９ＶＯＬ．２０ＮＯ．１１胡椒醇提物的药理学实验研究邓永坤，董寿堂，王银辉，李辉’（大理学院・药学院，云南大理６７１０００）摘要：目的探讨胡椒醇提物局部外涂的药理作用。
方法分别采用二甲苯致小鼠耳廓肿胀炎症模型和磷酸组胺致豚鼠足部瘙痒模型测试胡椒７０％乙醇提取液的局部抗炎止痒作用；利用图像分析系统测定小鼠耳廓局部应用胡椒７０％乙醇提取液前与应用后５，１０，２０ｍｉｎ及腹腔注射’肾上腺素后５，１０，１５，２０ｍｉｎ耳廓细动、静脉１：７径和细静脉血流态，由此评价其对小鼠耳廓正常微循环和肾上腺素引起的微循环障碍的作用。
结果胡椒７０％乙醇提取液局部外涂能显著抑制二甲苯所致小鼠耳廓肿胀；显著提高豚鼠足部磷酸组胺致痒阈；显著增加正常小鼠细动、静脉口径及细静脉血流速度，并能明显对抗肾上腺素引起的细动、静脉收缩和细静脉血流速度减慢。
结论胡椒７０％乙醇提取液局部外用具抗炎、止瘁和改善微循环作用。
关键词：胡椒；药理作用；抗炎；止痒；微循环中图分类号：Ｒ２８５．５文献标识码：Ａ文章编号：１００８－０８０５（２００９）１ｌ－２７９０－０２ＥｘｐｅｒｉｍｅｎｔａｌＳｔｕｄｙｏｆＡｌｃｏｈｏｌＥｘｔｒａｃｔｆｒｏｍＰｅｐｐｅｒｏｎＰｈａｒｍａｃｏｌｏｇｙＤＥＮＧＹｏｎｇ．ｋｕｎ．ＤＯＮＧｓｈｏｕ—ｔａｎｇ，ＷＡＮＧＹｉｎ—ｈｕｉ，ＬＩＨｕｉ＋（ＳｃｈｏｏｌｏｆＰｈａｒｍａｃｏｌｏｇｙ，ＤａｌｉＣｏｌｌｅｇｅ，Ｄａｌｉ，Ｙｕｎａｎ６７１０００，Ｃｈｉｎａ）Ａｂｓｔｒａｃｔ：ＯｂｊｅｃｔｉｖｅＴｏｉｎｖｅｓｔｉｇａｔｅｔｈｅｐｈａｒｍａｃｏｌｏｇｉｃａｌｅｆｆｅｃｔｏｆａｌｃｏｈｏｌｅｘｔｒａｃｔｆｒｏｍｐｅｐｐｅｒｏｎｔｏｐｉｃａｌａｐｐｌｉｃａｔｉｏｎ．ＭｅｔｈｏｄｓＴｗｏｅｘｐｅｒｉｍｅｎｔａｌｍｏｄｅｌｓｉｎｃｌｕｄｉｎｇｘｙｌｅｎｅ——ｉｎｄｕｃｅｄｅａｒｅｄｅｍａｉｎｍｉｃｅａｎｄｈｉｓｔａｍｉｎｅｐｈｏｓｐｈａｔｅｉｎｄｕｃｅｄ—－ｆｏｏｔｐｒｕｒｉ・・ｔｕｓｉｎｇｕｉｎｅａｐｉｇｓｗｅｒｅｅｍｐｌｏｙｅｄｔｏｅｖａｌｕａｔｅｔｏｐｉｃａｌｌｙａｎｔｉ—－ｉｎｆｌａｍｍａｔｏｒｙａｎｄａｎｔｉｐｒｕｒｉｔｉｃａｃｔｉｏｎｏｆ７０％ａｌｃｏｈｏｌｅｘｔｒａｃｔｆｒｏｍｐｅｐ・－ｐｅｒ．Ｉｎｔｅｒｎａｌｄｉａｍｅｔｅｒｓｏｆａｕｒｉｃａｒｔｅｒｉｏｌｅｓａｎｄｖｅｎｕ］ｅｓｉｎｍｉｃｅｗｅｒｅｍｅａｓｕｒｅｄｉｎｉｔｉａｌｌｙａｎｄｔｈｅｎ５，１０ａｎｄ２０ｒａｉｎａｆｔｅｒａｐｐｌｉｃａｔｉｏｎｏｆ７０％ａｌｃｏｈｏｌｅｘｔｒａｃｔｆｒｏｍｐｅｐｐｅｒａｎｄａｇａｉｎ５，１０，１５ａｎｄ２０ｍｉｎａｆｔｅｒｉｐＡｄｒｅｎａｌｉｎｅｗｉｔｈｉｍａｇｅａｎａｌｙｓｉｓｓｙｓｔｅｍ．Ｓｉｍｕｌｔａｎｅｏｕｓｌｙｂｌｏｏｄｆｌｏｗｓｔａｔｅｉｎａｕｒｉｃｖｅｎｕｌｅｓｗａｓｏｂｓｅｒｖｅｄ．ＲｅｓｕｌｔｓＴｏｐｉｃａｌａｄｍｉｎｉｓｔｒａｔｉｏｎｏｆ７０％ａｌｃｏｈｏｌｅｘｔｒａｃｔｆｒｏｍｐｅｐｐｅｒｓｉｇｎｉｆｉｃａｎｔｌｙｉｎ－ｈｉｂｉｔｅｄｅａｒｅｄｅｍａｉｎｄｕｃｅｄｂｙｘｙｌｅｎｅ，ｓｉｇｎｉｆｉｃａｎｔｌｙｉｎｃｒｅａｓｅｄｔｈｒｅｓｈｏｌｄｑｕａｎｔｉｔｙｏｆｈｉｓｔａｍｉｎｅｐｈｏｓｐｈａｔｅｗｉｔｈｗｈｉｃｈｅｌｉｃｉｔｅｄｐｒｕｒｉｔｕｓｉｎｇｕｉｎｅａｐｉｇｓ，ｓｉｇｎｉｆｉｃａｎｔｌｙｄｉｌａｔｅｄａｕｒｉｃａｒｔｅｒｉｏｌｅｓａｎｄｖｅｎｕｌｅｓｉｎｍｉｃｅ，ｓｐｅｅｄｅｄｕｐｂｌｏｏｄｆｌｏｗｒａｔｅｏｆｖｅｎｕｌｅｓ．Ｆｕｒｔｈｅｒｍｏｒｅ，ｉｔｉｎ‘ｈｉｂｉｔｅｄａｄｒｅｎａｌｉｎｅ—ｉｎｄｕｃｅｄｃｏｎｔｒａｃｔｉｏｎｏｆａｒｔｅｒｉｏｌｅｓａｎｄｖｅｎｕｌｅｓａｓｗｅｌｌａｓｔｈｅｒｅｄｕｃｔｉｏｎｏｆｂｌｏｏｄｆｌｏｗｒａｔｅｏｆｖｅｎｕｌｅｓ．Ｃｏｎｃｌｕ－ｓｉｏｎ７０％ａｌｃｏｈｏｌｅｘｔｒａｃｔｏｆｐｅｐｐｅｒｈａｓｐｈａｒｍａｃｏｌｏｇｉｃａｌａｃｔｉｖｉｔｉｅｓｏｆａｎｔｉ—ｉｎｆｌａｍｍａｔｉｏｎ，ａｌｌｅｖｉａｔｉｎｇｉｔｃｈｉｎｇａｎｄｉｍｐｒｏｖｉｎｇｍｉｃｒｏ－ｃｉｒｃｕｌａｔｉｏｎ．Ｋｅｙｗｏｒｄｓ：Ｐｅｐｐｅｒ；Ｐｈａｒｍａｃｏｌｏ舀ｃａｌａｃｔｉｏｎ；Ａｎｔｉ—ｉｎｆｌａｍｍａｔｏｒｙ；Ａｌｌｅｖｉａｔｅｉｔｃｈｉｎｇ；Ｍｉｅｒｏｃｉｒｃｕｌａｔｉｏｎ胡椒是传统中药，为胡椒科植物胡椒ＰｉｐｅｒｎｉｇｒｕｍＬ．的干燥近成熟或成熟果实，主要含生物碱和挥发油，此外还含木脂素、有机酸、酚类化合物和微量元素。
肛肠病外文资料
1) anorectal operation肛肠科手术1.The uroschesis after the anorectal operation is the most common complication,it not only influences the recovery and the relationship between doctor and patient,but also even leads to the nonvolatile damage of the detrusor muscle.术后尿潴留是肛肠科手术的最长见的并发症,它不仅可以影响术后的恢复速度和患者对医护人员的信任程度,甚至可能导致永久性的逼尿肌的损伤。
2) Anorectal肛肠3) anal operation肛肠手术1.Conclusion The PCIMA might fit for the anal operation patient especially after operation. 目的通过对肌肉内自控镇痛(PCIMA)技术用于肛肠手术后患者的观察,研究这种镇痛方法对肛肠手术后镇痛的可行性。
4) anus dropping肛肠点滴1.objective:Observing the curative effect of liquid of huayuzhitong anus dropping on endomdtriosis(EMS).目的:研究中药化瘀止痛液肛肠点滴治疗子宫内膜异位症的临床疗效。
5) anorectal diseases肛肠病1.Clinical study on perioperative analgesic therapy for anorectal diseases;肛肠病围手术期镇痛治疗的临床研究6) anorectal disease肛肠疾病1.Endosonographic diagnosis in anorectal disease s;直肠腔内B超检查诊断肛肠疾病2.Objective To study how to make the Compound CEC Ointment and observe its clinical effect on promoting the healing of wound after the operation on anorectal disease s.值得在肛肠疾病术后换药中推广应用。
研究药物抗炎作用的实验方法
研究药物抗炎作用的实验方法In the field of pharmaceutical research, finding effective methods to study the anti-inflammatory effects of drugs is crucial in the development of new medications. 药物抗炎作用的实验方法是药物研究中至关重要的一环。
There are several experimental methods that can be used to evaluate the anti-inflammatory properties of a drug, each with its own strengths and limitations. 有几种实验方法可以用于评估药物的抗炎特性，每种方法都有其优点和局限性。
One commonly used method is the use of in vitro cell culture models to test the effects of a drug on inflammatory markers and cytokine production. 一个常用的方法是使用体外细胞培养模型来测试药物对炎症标志物和细胞因子产生的影响。
This method allows researchers to observe the direct effects of the drug on specific cells involved in the inflammatory response. 这种方法使研究人员能够观察药物对参与炎症反应的特定细胞的直接影响。
Another approach is the use of animal models of inflammation, such as mice or rats, to study the systemic effects of a drug on the inflammatory response. 另一种方法是利用小鼠或大鼠等动物模型来研究药物对全身炎症反应的影响。