Dependence of Heliospheric Lyman-alpha Absorption on the Interstellar Magnetic Field
等离子体处理对紫云英种子萌发和生理特性的影响

第 32 卷第 10 期Vol.32,No.10129-1402023 年 10 月草业学报ACTA PRATACULTURAE SINICA李想,张梦,刘春增,等. 等离子体处理对紫云英种子萌发和生理特性的影响. 草业学报, 2023, 32(10): 129−140.LI Xiang,ZHANG Meng,LIU Chun-zeng,et al. Effects of dialectric barrier discharge plasma treatment on seed germination and physiological characteristics of Astragalus sinicus. Acta Prataculturae Sinica, 2023, 32(10): 129−140.等离子体处理对紫云英种子萌发和生理特性的影响李想1,张梦2,刘春增2,朱益飞3,叶晓馨1*(1.安徽大学资源与环境工程学院,安徽合肥 230601;2.河南省农业科学院植物营养与资源环境研究所,河南郑州 450002;3.空军工程大学航空工程学院,陕西西安 710038)摘要:为打破紫云英种子硬实,提高种子活力和发芽一致性,本研究以赣紫75-3-51和信紫1号为供试材料,采用室内发芽试验探讨了不同剂量等离子体处理(7、8、9 kV电压分别处理1、3、5、10 min)对紫云英种子活力、幼苗生长、抗氧化酶活性以及渗透调节物质含量的影响,以期为紫云英种子播前处理技术提供参考。
结果表明:等离子体处理对2种紫云英种子的发芽率和发芽势没有显著影响,但提高了紫云英种子活力。
不同品种紫云英对等离子体处理的响应存在差异。
等离子体处理对赣紫75-3-51生长存在低促高抑的现象,幼苗鲜重以及胚芽长度均随处理时间增加呈单峰曲线变化。
信紫1号幼苗鲜重在高剂量(9 kV处理10 min)等离子体处理条件下显著降低,较对照降低了20.5%。
严重急性呼吸系统综合症冠状病毒-2与横纹肌溶解症

jtmUiMeKR l f2021'心40⑵:269-75-269-前后miRNA的差异表达[J].江苏医药,2015(8):880-883'864.[25]KACHGAL S,PUTNAM A J.Mesenchymal stem cells fromadipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms&J].Angiogene-sR'2011,14(1):47-59.[26]GU H J,GUO F F,ZHOU X,et al.The Tiniulotn ot osto-genicdieeeniiaiion o\human adipose-deeived siem ce e s by ionie products from akermanite dissolution via activation of ihe ERK p(ihw(y[J].Biom(ieeies,2011,32(29):7023-7033.[27]KASIRR,VERNEKARVN, LAURENCINCT.Regeneeiiveengineering of carRGge using adipose-derived stem cells[J].R'g'n Eng T eans eM'd,2015,1(1-4):42-49.[28]RAYP,TORCKA,QUIGLEYL,'paeaiiv'ieansceip-tme profiling of the human and mouse dorsal not ganglia:an RNA-seq-based resource for pain and sensory neuroscience research[J].Pain,2018,159(7):1325-1345.[29]GERMAN S J,BEHBAHANI M'MIBTTINEN S,et al.PnlReration and dRferentiaUon of adipose stem cells towards smooth muscle cells on poly(WiRethyTne carbonate)mem-beanes[J].MaceomoeSymp,2013,334(1):133-142.[30]SUN Y Y,LUB L,DENG J C,et al.IT-7enhances the dRfer-entiation of adipose-derived stem cells toward lymphatic en-dotheTai cells through A K T signaling&J].Cel l Biol Int, 2019,43(4):394-401.[ 31]HELLSTROM M, PHNGLK,HOFMANNJJ,eia.D A4sig-naUing through Nothl reaulates formation of tip ce—s duringangiogenesis[J].Na iu ee,2007,445(7129):776-780.[32]KIM JH,PEACOCK M R,GEORGE S C,eia.BMP9inducesEpheinB2eapee s ion in endoiheiaAcesiheough an AG1-BMPRI I ActRI I-ID1/ID3-dependent pathway:implications for henditaR hemorrhagic tTngiecmsib type II[J].Angiogenesis,2012,15(3):497-509.&33]殷令妮,陈德宣.PI3K/Akt通路在低氧诱导脂肪干细胞增殖和向内皮细胞分化中的作用& J].中国组织工程研究' 2020,24(19):3004-3009.[34]VOLZ A C,HUBER B,KLUGER P J.Adipose-de eived siemcell diRenntiation as a basic tol for vascularized adipose Rs-sue engineering[J].DiRenn/aUon'2016,92(1-2):52-64.[35]DOLDERERJH,MEDVEDF,HAAS RM,eiae.Angiogenesisand vascueaeisaiion in adiposeii s ueengineeeing[J].Handchi eMik eochi eP,2013,45(2):99-107.[36]KAYABOLENA,KESKIND,AYKANA,eiae.Naiiveeaieacellular matWa/Pbroin hydrogels for adipose tissue engineer-ingwiih enhanced vascueaeieaiion[J].Biomed Maiee,2017, 12(3):035007.[37]PARK I S,KIM S H,JUNG丫,0oT EndoOelial diffennRuiion and vascu ogenesisinduced byiheee-dimensionaAadi-pose-deeived siem ce e s[J].AnaiRec(Hoboken),2013,296(1):168-177.[ 38]MAZINIL,ROCHETTEL,ADMOUB,eiae.Hopesand eimiis ot adipose-derived stem cells(ADSCs)and mesenchymal siem ce e s(MSCs)in wound heaeing[J].IniJMoeSci, 2020,21(4):1306.•综述・严重急性呼吸系统综合症冠状病毒*与横纹肌溶解症韦湛海,吕海芹(东南大学医学院,江苏南京210009)&摘要]新型冠状病毒病(COVID-19)是由严重急性呼吸系统综合症冠状病毒-2(SARS-CoV-2)感染引起的世界性大流行疾病'严重威胁人类健康。
冰川下的生物对氧气的需求

冰川下的生物对氧气的需求英文回答:Glaciers are icy bodies that form from the accumulation of snow over many years. They are found in polar regions, high mountain ranges, and even in some lower latitude areas. These frozen landscapes are home to a variety of organisms, both visible and microscopic. However, the livingconditions beneath glaciers are extremely challenging, and the organisms that inhabit these environments have adaptedto survive in harsh conditions.One of the key factors that affects the survival of organisms beneath glaciers is the availability of oxygen. Oxygen is essential for the respiration process, which provides energy for living organisms. However, the amountof oxygen dissolved in water decreases as the temperature drops. This means that the organisms living beneathglaciers have to cope with lower levels of oxygen comparedto those in other aquatic environments.To overcome this challenge, some organisms have developed unique physiological adaptations. For example, certain species of bacteria that live beneath glaciers can use alternative respiratory pathways that do not rely on oxygen. These bacteria are capable of carrying out anaerobic respiration, which allows them to obtain energy without the need for oxygen. This adaptation enables them to survive in oxygen-depleted environments.Another example of adaptation to low oxygen levels is seen in the invertebrates that inhabit the subglacial environment. These organisms have evolved specialized respiratory systems that maximize oxygen uptake. For instance, some species of midge larvae have elongated respiratory tubes that extend above the water surface, allowing them to access oxygen-rich air. These larvae are often referred to as "glacier worms" due to their ability to survive in such extreme conditions.In addition to physiological adaptations, organisms beneath glaciers also rely on other strategies to obtainoxygen. For instance, the movement of water within the glacier can create pockets of oxygen-rich water, providinga source of oxygen for the organisms. Some organisms may also actively migrate towards areas with higher oxygen concentrations, utilizing their mobility to seek out more favorable conditions.In conclusion, the organisms living beneath glaciers have adapted to cope with the low levels of oxygen in these environments. They have developed physiological adaptations, such as alternative respiratory pathways and specialized respiratory systems, to obtain energy and survive inoxygen-depleted conditions. The ability to thrive in such extreme environments showcases the remarkable resilienceand adaptability of these organisms.中文回答:冰川是多年积雪的冰体形成的。
【高中生物】科学家设计出阿尔茨海默病抗体

【高中生物】科学家设计出阿尔茨海默病抗体
美国伦斯勒理工学院研究人员开发了一种新的设计抗体方法,被用来制成中和阿尔茨海默病中有害蛋白的抗体。
《美国国家科学院院刊》上介绍的方法被视为了解复杂疾病病理学的工具,也可用于开发新的抗体药物。
抗体是由免疫系统产生的抗击感染和疾病的大型蛋白。
它是由大的y型蛋白和一些小的环形肽组成。
这些环形肽可与有害入侵者结合,如病毒和细菌。
抗体与目标结合后,免疫系统就会派遣细胞摧毁这些入侵者。
找到正确的抗体是决定死亡还是从疾病中恢复的关键。
科学家们一直在寻找设计抗体的方法。
然而,设计一种仅针对目标的抗体非常复杂,这阻碍了科学家实现这一目标的愿望。
一种抗体在设计时,肽环的排列和顺序极其重要。
只有非常特殊的肽环组合才能与目标结合。
肽环有数亿种排列顺序,似乎不可能找到哪种循序的排列能与目标结合。
新的抗体设计方法被用来制造针对人体的破坏性分子?阿尔茨海默病蛋白抗体。
这项研究使用了类似于阿尔茨海默病中蛋白质结合的分子间相互作用。
阿尔茨海默病的特征是蛋白质相互结合形成有毒颗粒。
阿尔茨海默病中的蛋白颗粒将损害大脑正常的功能。
类似毒性蛋白颗粒的形成也是帕金森氏病和疯牛病的关键。
这种新的阿尔茨海默抗体只作用于有害的结合蛋白,而不会损害与疾病无关的单一蛋白。
研究人员还发现了这项技术在帕金森病治疗中的潜力。
从长远来看,随着科学家向大脑释放药物方法的增多,这种新的抗体设计方法将会帮助开发新的药物,用于治疗类似阿尔茨海默病这类疾病。
【2019最新】美国生物化学家—伊莱亚斯 科里-范文模板 (1页)

【2019最新】美国生物化学家—伊莱亚斯科里-范文模板本文部分内容来自网络整理,本司不为其真实性负责,如有异议或侵权请及时联系,本司将立即删除!== 本文为word格式,下载后可方便编辑和修改! ==美国生物化学家—伊莱亚斯科里伊莱亚斯·科里1928年生于美国,1848年获得了学士学位,23岁从美国麻省理工学院获得博士学位。
现任哈佛大学教授。
科里从20世纪50年代后期开始从事有机合成的研究工作,30多年来他和他的同事们共同合成了几百个重要天然化合物。
这些天然化合物的结构都比较复杂,合成难度很大。
按照科里和他的学生成学敏在1989年出版的专著《化学合成的逻辑》一书的分类,他的合成工作主要包括:①大环结构,如红霉素大环内酯;②杂环结构,如翼萼藤碱;③倍半萜类化合物,如长叶烯;④多环异戊二烯类化合物,如银杏内酯;⑤前列腺素类化合物,如前列腺素E1;⑥白三烯类化合物,如白三烯A等。
科里不仅在有机合成研究方面显示出他的天才,而且他还总结出重要理论。
1967年他提出了具有严格逻辑性的“逆合成分析原理”,以及合成过程中的有关原则和方法。
按照他的原理,使很多合成难度较大的有机化合物,得到较高的收率而获得成功。
科里还开创了运用计算机技术进行有机合成设计。
按照他的原理,他和他的学生卫普克编制了第一个计算机辅助有机合成路线设计程序(DCSS)。
由此程序为基础,还开发了许多新的程序。
这实际上是使他的“逆合成分析原理”及有关原则、方法数字化。
由于科里提出有机合成的“逆合成分析方法”并成功地合成50多种药剂和百余种天然化合物,对有机合成有重大贡献,而获得1990年诺贝尔化学奖。
细胞外基质相关基因预后模型在脑胶质瘤中预测预后能力分析

细胞外基质相关基因预后模型在脑胶质瘤中预测预后能力分析贾牧原;刘羽阳;胡文涛;陈俊燚;张洪俊;龚欢欢;吴剑慧;任博文;刘嘉霖;陈凌【期刊名称】《国际神经病学神经外科学杂志》【年(卷),期】2024(51)2【摘要】目的构建细胞外基质(ECM)相关基因预后模型,评价其预测胶质瘤患者预后的能力,探索基于该模型的胶质瘤免疫微环境特征。
方法基于肿瘤基因组图谱(TCGA)和基因型-组织表达(GTEx)数据库中胶质瘤以及正常脑组织数据,筛选获得差异基因(DEGs);基于基因本体论(GO)数据库获取ECM相关基因,基于单因素Cox 回归分析获取胶质瘤预后基因。
将上述三部分取交集获得重叠候选基因,再经由Lasso分析获取最佳的4基因预后模型,并于TCGA以及中国脑胶质瘤图谱数据库(CGGA)中胶质瘤队列中进行生存分析和Cox回归分析。
基于4基因预后模型以及TCGA患者预后数据构建预后列线图,并在CGGA胶质瘤队列中进行验证。
最后,基于富集分析、免疫检查点分析以及免疫浸润分析探索4基因预后模型相关的免疫微环境特征。
结果22个重叠候选基因经由Lasso分析后获得最佳4基因预后模型,该模型的风险评分能够较好地预测TCGA以及CGGA胶质瘤患者的预后,并且是危险因素。
细胞系验证实验中提示U251细胞系(人源胶质瘤细胞)最佳4基因表达均高于HA1800(人源星形胶质细胞),符合TCGA以及CGGA数据库分析结果。
基于4基因预后模型构建的预后列线图同样具有较好地预测患者预后的能力。
高风险组患者肿瘤组织内具有较高水平的M2型巨噬细胞浸润且免疫检查点相关分子(PD-L1,B7-H3,CTLA4,PD1,TIM3以及LAG3)高于低风险组。
结论ECM相关基因模型以及预后列线图均能够较好地预测胶质瘤患者的预后,高风险组患者具有抑制性免疫微环境特征,免疫检查点抑制剂可能是该类患者的潜在治疗方式。
【总页数】13页(P35-47)【作者】贾牧原;刘羽阳;胡文涛;陈俊燚;张洪俊;龚欢欢;吴剑慧;任博文;刘嘉霖;陈凌【作者单位】北京美中爱瑞肿瘤医院;解放军医学院;解放军联勤保障部队九二〇医院;中南大学湘雅三医院重症医学科;解放军总医院第一医学中心神经外科医学部【正文语种】中文【中图分类】R739.41【相关文献】1.脑胶质瘤中细胞凋亡与相关基因Fas、survivin表达的相关性及预后意义2.基于自噬相关基因构建的预后模型对脑胶质瘤免疫微环境的影响3.基于数据库数据分析脑胶质瘤组织中FN1基因的表达变化及其预后预测效能4.预后营养指数及其他临床指标与脑胶质瘤术后患者预后的相关性分析5.结直肠癌预后相关铁死亡基因筛选及预后预测模型构建因版权原因,仅展示原文概要,查看原文内容请购买。
中脑红核突触素的表达与突触发育的关系

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(武汉大学)分子生物学考研名词汇总

(武汉大学)分子生物学考研名词汇总●base flipping 碱基翻出●denaturation 变性DNA双链的氢键断裂,最后完全变成单链的过程●renaturation 复性热变性的DNA经缓慢冷却,从单链恢复成双链的过程●hybridization 杂交●hyperchromicity 增色效应●ribozyme 核酶一类具有催化活性的RNA分子,通过催化靶位点RNA链中磷酸二酯键的断裂,特异性地剪切底物RNA分子,从而阻断基因的表达●homolog 同源染色体●transposable element 转座因子●transposition 转座遗传信息从一个基因座转移至另一个基因座的现象成为基因转座,是由转座因子介导的遗传物质重排●kinetochore 动粒●telomerase 端粒酶●histone chaperone 组蛋白伴侣●proofreading 校正阅读●polymerase switching 聚合酶转换●replication folk 复制叉刚分开的模板链与双链DNA的连接区●leading strand 前导链在DNA复制过程中,与复制叉运动方向相同,以5’-3’方向连续合成的链被称为前导链●lagging strand 后随链在DNA复制过程中,与复制叉运动方向相反的,不连续延伸的DNA链被称为后随链●Okazaki fragment 冈崎片段●primase 引物酶依赖于DNA的RNA聚合酶,其功能是在DNA复制过程中合成RNA引物●primer 引物是指一段较短的单链RNA或DNA,它能与DNA的一条链配对提供游离的3’-OH末端以作为DNA聚合酶合成脱氧核苷酸链的起始点●DNA helicase DNA解旋酶●single-strand DNA binding protein, SSB 单链DNA结合蛋白●cooperative binding 协同结合●sliding DNA clamp DNA滑动夹●sliding clamp loader 滑动夹装载器●replisome 复制体●replicon 复制子单独复制的一个DNA单元称为一个复制子,一个复制子在一个细胞周期内仅复制一次●replicator 复制器●initiator protein 起始子蛋白●end replication problem 末端复制问题●homologous recombination 同源重组●strand invasion 链侵入●Holliday junction Holliday联结体●branch migration 分支移位●joint molecule 连接分子●synthesis-dependent strand annealing, SDSA 合成依赖性链退火●gene conversion 基因转变●conservative site-specific recombination, CSSR 保守性位点特异性重组●recombination site 重组位点●recombinase recognition sequence 重组酶识别序列●crossover region 交换区●serine recombinase 丝氨酸重组酶●tyrosine recombinase 酪氨酸重组酶●lysogenic state 溶原状态●lytic growth 裂解生长●transposon 转座子能够在没有序列相关性的情况下独立插入基因组新位点上的一段DNA序列,是存在与染色体DNA上可自主复制和位移的基本单位。
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1JILA, University of Colorado, 440 UCB, Boulder, CO 80309-0440; woodb@, jlinsky@.
Voyager 1 recently encountered the TS at a distance of 94 AU from the Sun in roughly the upwind direction relative to the ISM flow (Stone et al. 2005). However, the locations of the more distant HP and BS remain observationally uncertain. In general, there are very few observational constraints for the properties of the heliosphere beyond the TS. One of the few exceptions is heliospheric Lyα absorption, which is observable in Hubble Space Telescope (HST) spectra of nearby stars.
Unlike the ionized component of the ISM, the neutrals in the ISM can penetrate into all regions of the heliosphere. Charge exchse neutrals create populations of hot H I that permeate the heliosphere, and it is these neutrals that produce absorption signatures in stellar Lyα lines observed by HST. For most lines of sight, the absorption is dominated by H I in the so-called “hydrogen wall” region in between the HP and BS (Baranov et al. 1991; Wood et al. 2005b), but in downwind directions absorption from heliosheath neutrals, created by charge exchange between the TS and HP, can be paramount (Izmodenov et al. 1999; Wood et al. 2007). The heliospheric absorption is only detectable when the ISM absorption for the observed line of sight is not too broad to obscure the absorption. In upwind directions the interstellar H I column density (in cm−2) must be log N(H I) < 18.2 to detect heliospheric absorption, but in downwind directions one must have log N(H I) < 17.8 (Wood et al. 2005a). Astrospheric absorption from the wind-ISM interaction region surrounding the observed star can also sometimes be detected.
–3–
detected by HST.
However, the exact amount of absorption predicted by the models is dependent on the parameters that are assumed for the Local Interstellar Cloud (LIC) in which the Sun resides (Lallement & Bertin 1992). Some aspects of the ambient ISM are known very well, such as the LIC flow speed and direction (e.g., Witte 2004; M¨obius et al. 2004), but others are not known as precisely. Thus, there has been hope that the Lyα absorption can help constrain certain properties of the ISM. Izmodenov et al. (2002), for example, experimented with numerous different models assuming different combinations of ISM proton and H I densities. The absorption predicted by the models does vary with the input parameters, but the absorption diagnostic seems to have only a modest sensitivity to most input parameters of interest, making it difficult to simply define a range of parameters that are consistent with the data. The dependence of the predicted absorption on the nature of the hydrodynamic code used in the modeling is also a problem (Wood et al. 2000; Izmodenov et al. 2002). The source of this difficulty lies in the complexity of H I velocity distributions within the heliosphere, which are non-Maxwellian (e.g., Izmodenov et al. 2001) and therefore can only be modeled with fully kinetic or complex multi-fluid codes.
2Lomonosov Moscow State University, Dept. of Aeromechanics and Gas Dynamics, Moscow 119899, Russia; izmod@ipmnet.ru.
3Institute for Problems in Mechanics RAS, Prospekt Vernadskogo 101-1, Moscow 117526, Russia; and Space Research Institute (IKI) RAS
ABSTRACT
We use newly developed 3D kinetic MHD models of the heliosphere to predict heliospheric H I Lyα absorption for various lines of sight. These predictions are compared with actual Lyα spectra from the Hubble Space Telescope, many of which have yielded previous detections of heliospheric absorption. We find that the absorption predicted by the models is weakly affected by both the magnitude and orientation of the assumed ISM magnetic field. Models with B = 1.25 − 2.5 µG and an angle of α = 15 − 45◦ with respect to the upwind direction of the ISM flow generally provide the best fits to the data, but the sensitivity of the Lyα absorption to many model input parameters makes it difficult to fully characterize the region of parameter space allowed by the data. We also use the models to assess the degree to which heliospheric asymmetries induced by the ISM field should be apparent in Lyα absorption. An ISM field that is skewed with respect to the ISM flow vector results in substantial azimuthal asymmetries in both the hydrogen wall and heliosheath, but only the heliosheath asymmetries yield potentially detectable asymmetries in Lyα absorption; and then only in downwind directions, where comparison with the data is complicated by few actual absorption detections and an insufficient model grid extent.