CPDB基因毒性杂质列表
基因毒性杂质-基毒、重金属资料
遗传毒性杂质遗传毒性：泛指各种因素（物理、化学因素）与细胞或生物体的遗传物质发生作用而产生的毒性。
1、致突变性：与DNA相互作用产生直接潜在的影响，使基因突变（bacteria reverse mutation（Ames）试验）2、致癌性：具有致癌可能或倾向（需要长期研究！）3、警示结构特征：一些特殊的结构单元具有与遗传物质发生化学反应的能力，会诱导基因突变或者导致染色体重排或断裂，具有潜在的致癌风险。
遗传毒性物质：在很低的浓度下即可诱导基因突变以及染色体的断裂和重排，因此具有潜在的致癌性。
EMA通告（1）、具体事项：1、哪些品种中会出现甲磺酸酯（或甲磺酸烷基酯）。
特别是甲磺酸盐等形式的API或其合成中用到甲磺酸的API，甲磺酸烷基酯-甲磺酸甲酯、乙酯、其它低级醇酯，应认定为潜在杂质。
2、羟乙基磺酸盐、苯磺酸盐、对甲苯磺酸盐的API。
应说明类似物质磺酸烷基酯或芳基酯污染的危险。
3、限度要求：无其它毒性数据时，这些高风险杂质应依据TTC设定限度。
1.5μg÷以g为单位的最大日剂量得ppm限度。
4、法律依据：EP专论要求凡以甲磺酸盐和羟乙基磺酸盐形式存在的API，均应在其生产过程中采取以下安全措施：必须对生产工艺进行评估以确定家磺酸烷基酯（羟乙基磺酸烷基酯）形成的可能，特别是反应溶媒含低级醇的时候，很可能会出现这些杂质。
必需时需对生产工艺进行验证以说明在成品中未检出这类杂质。
（2）、落实措施：1、API生产是否涉及在甲磺酸（羟乙基磺酸盐、苯磺酸盐、对甲苯磺酸等低分子量磺酸）或相应酰氯存在下，使用甲醇、乙醇、正丙醇、异丙醇等低级脂肪醇（如甲醇、乙醇、正丙醇、异丙醇等）。
2、对相应酯形成的可能性是否降到最低。
3、是否有有效的清除精制步骤。
设备清洗-是否设计的低级脂肪醇的使用（方法，TTC限度）？起始物料（低分子量磺酸盐或酰氯）中是否控制了其低级脂肪醇酯（方法，TTC限度）？当被磺酸酯或相关物质污染的磺酸用于API合成时能否保证其中潜在的遗传毒性杂质不超过TTC？应考虑各种烷基或芳基磺酸酯杂质累积的风险。
基因毒性杂质培训 PPT课件
对甲苯磺酸季戊酯（布洛芬）： 苯：溶剂石油醚可能含有苯
右旋布洛芬中可能含有的基因毒性杂质
右旋布洛芬中合成路线
甲苯中要控制苯！
布洛芬赖氨酸中可能含有的基因毒性杂质
布洛芬赖氨酸合成工艺
=
布洛芬赖氨酸水杨醛的限度问题
台湾2016年9月缺陷信及回复：
氟马西尼合成工艺
氟马西尼中N,N-二甲苯胺基因毒性
盐酸格拉司琼中可能含有的基因毒性杂质
Granisetron起始原料1-甲基吲唑-3-羧酸 中可能含有的基因毒性杂质
Granisetron起始原料氮杂壬胺可能含有的基因毒性杂质
盐酸格拉司琼中可能含有的基因毒性杂质
盐酸格拉司琼欧洲药品质量管理局(EDQM) 缺陷信
磷酸氟达拉滨中可能含有的基因毒性杂质
Fludarabine起始原料合成工艺
磷酸氟达拉滨合成工艺
氯苄
氯苄的毒性资料
The Carcinogenic Potency Database (CPDB)致癌物数据库公布的1547种致癌物质中有氯苄：
托拉塞米中可能含有的基因毒性杂质
托拉塞米起始原料合成工艺
O
O NH2 A Carbamates 氨基甲酸类
AA NN
AR Hydrazines and azo Compounds 肼和偶氮化合物
EWG
Michale-reactive Acceptors 迈克尔加成反应受体
O P
OR
O S
OR
Alkyl Esetrs of Phosphonates or Sulfonates 膦酸酯或者磺酸酯
D-（+）-樟脑磺酸乙酯
基因毒性杂质(genotoxic
TTC用于计算未做研究的化学物质的接触量，这些 化学物质不会有明显的致癌性或者其他毒性。
ConcentrationLimit ( ppm) TTC (ug / day) dose(g / day)
TTC理论不可以应用于那些毒性数据（长期研究） 充分的致癌物质，也不可以做高风险毒性物质的风 险评价。
TTC是一个风险管理工具，它使用的是概率方法。所以 TTC不能被理解为绝对无风险的保障。
TTC
意思是：假如有一个基因毒性杂质，并且我们对 它的毒性大小不了解，如果它的每日摄入量低于 TTC值，那么，该基因毒性杂质的致癌风险将不 会高于100000分之一的概率。
某些特定情况，TTC值高于1.5μg/day也是可以 接受的。比如药物的短期接触，即治疗某些声明 预期在5年以下的某些严重疾病，或者这种杂质是 一种已知物质，人类在其他方式上对它的摄入量 会更高（比如在食品上）。这个需要根据实际情 况再进行推算。
应该有合理的分析方法去检测和量化这些杂质的 残留量。
毒理学研究
为一个不存在阀值的基因毒性致癌物定义一个安 全的摄入量水平（零风险观点）是不可能的，并 且从活性药物成分中完全的除去基因毒性杂质经 常是很难做到。这样就要求我们建立一个可接受 的风险水平，例如对一个低于可忽略风险的每日 摄入量进行评价。
判断是否为基因毒性杂质
通过Carcinogenic potency database (CPDB) 数据库查询，数据库中现有1574种致癌物质的列 表。链接 /chemnamein dex.html ，还可查询到关于基因毒性方面研究 的出版物。
基因毒性杂质卤代烃的风险评估
有数据表明氯乙烷、氯甲烷为基因毒性杂质，因 此有理由怀疑其他低分子卤代烃类也有类似的作 用。在生产中应该对其进行相应的控制。
基因毒性杂质
1 5
药品杂质引入风险评估
需要重点做风险评估工作 常见已知杂质引入途径
起始物料及已知杂质 中间体 试剂&溶剂&催化剂 反应副产物、 降解杂质
常见未知杂质引入途径
起始物料引入未知杂质、 起始物料杂质产生的杂质、 生产设备引入的杂质 包材浸出物杂质 环境引入杂质（生产用水等）
基于风险评估的药物杂质研究分析方法开发策略 & 杂质研究常见问题解析 汇报人：杨爔炎 2019.03
一、药品杂质研究评估策略
提纲
二、痕量杂质定量分析方法的建立 三、案例分析与讨论
四、未知杂质分离鉴定案例分析
一、药品杂质研究评估策略
1.药品杂质研究的法规依据 2.药品杂质评估一般步骤
3.药品杂质来源途径分析
欧洲化学品管理局（ECHA）
已有文献报道
获取TD50、NOEL、ADI、PMTDI NOEL值与致癌致畸没有必然联系 查询的毒性研究文献全面性以及毒性 实验数据的解读需要专家的确认
1 1
常见物质的PDE数值举例
Name 氯甲烷 氯乙烷 氯异丙烷 氯乙酸 甲醛 乙醛 丙二醛 环氧丙醇 环氧氯丙烷 3-氯-1,2-丙二醇 1,3-二氯-2-丙醇 CAS 74-87-3 75-00-3 75-29-6 79-11-8 50-00-0 75-07-0 542-78-9 556-52-5 106-89-8 96-24-2 96-23-1 PDE(ug/day) 1361 1810 55500 3000 1.35 or 10000 153 122 4 2.96 PMTDI ：4ug/kg/day 10 Note ICH M7 ICH M7 ECHA ECHA/CPDB CPDB/ICH M7 CPDB CPDB（钠盐） ICH M7 CPDB（TD50） WHO/FAO NTP
基因毒性杂质-全面信息资料
Step 1:
Class1:Genotoxic Carcinogens
第1类：已知的、具有基因毒性（突变性）和致癌性 的杂质
Class2:Genotoxic Carc unknow
第2类：已知的、具有基因毒性（突变性），但致癌 性未知的杂质
Class3:AlertUnrelated to parent
TTC=1.5微克/天
每天摄入1.5微克的基因毒性杂质，被认为对于大 多数药品来说是可以接受的风险。
使得人一率是四分之一。
必须要强调的是TTC是一个风险管理工具，它采用的是概率的方法。 意思为：假如有一个基因毒性杂质，并且我们对它的毒性大小不太 了解，如果它的每日摄入量低于TTC值，那么它的致癌风险将不会高 于10－5的概率。
NOEL × 重量调整因子 F1 × F2 × F3 × F4 × F5
PDE NOEL F1 F2 F3 F4 F5
允许的日暴露量（mg/天） 观察不到影响的限值 物种之间的外推法因子（F1=12，从小鼠到人类） 个体差异因子 毒性研究的周期因子 严重毒性的因子 如果只有LOEL（可观察到效果最低限值）时的因子
大剂量、长期使用会引起耳毒性 有些特别敏感的病人，仅使用一次或短期使用，就出现了 听力损失。 研究表明，他们的一个基因上有一点(mtl555G)与别人不同， 这使他们对氨基糖甙类药物耳毒性的易感性大大增加。
是指能直接或间接损伤细胞DNA，产生致突变和致 癌作用的物质。
常用的缩写
PGLs（potentially genotoxic impurities有潜在基因毒性的杂质） GTLs（ genotoxic impurities基因毒性杂质）
基因毒性杂质介绍及检测方法
基因毒性杂质介绍及检测⽅法1什么是基因毒性杂质基因毒性杂质（或遗传毒性杂质，Genotoxic Impurity ，GTI）是指化合物本⾝直接或间接损伤细胞DNA，产⽣基因突变或体内诱变，具有致癌可能或者倾向。
潜在基因毒性的杂质（Potential Genotoxic Impurity ，PGI）从结构上看类似基因毒性杂质，有警⽰性，但未经实验证明的黄曲霉素类、亚硝胺化合物、甲基磺酸酯等化合物均为常见的基因毒性杂质，许多化疗药物也具有⼀定的基因毒性，它们的不良反应是由化疗药物对正常细胞的基因毒性所致，如顺铂、卡铂、氟尿嘧啶等。
2为何着重研究基因毒性杂质基因毒性物质特点是在很低浓度时即可造成⼈体遗传物质的损伤，进⽽导致基因突变并可能促使肿瘤发⽣。
因其毒性较强，对⽤药的安全性产⽣了强烈的威胁，近年来也越来越多的出现因为在已上市药品中发现痕量的基因毒性杂质残留⽽发⽣⼤范围的医疗事故，被FDA强⾏召回的案例，给药⼚造成了巨⼤的经济损失。
例如某知名国际制药巨头在欧洲市场推出的HIV蛋⽩酶抑制剂维拉赛特锭（Viracept， mesylate)，2007 年7⽉，EMA暂停了它在欧洲的所有市场活动，因为在其产品中发现甲基磺酸⼄酯超标，甲基磺酸⼄酯是⼀种经典的基因毒性杂质，该企业为此付出了巨⼤的代价，先内部调查残留超标的原因，因在仪器设备清洗时⼄醇未被完全清除⽽残留下来，与甲基磺酸反应形成甲基磺酸⼄酯。
在被要求解决污染问题后还被要求做毒性研究，以更好的评估对患者的风险。
同时有多达25000 名患者暴露于这个已知的遗传毒性。
直到解决了这所有问题后 EMA才恢复了它在欧洲的市场授权。
近年来各国的法规机构如ICH、FDA、EMA等都对基因毒性杂质有了更明确的要求，越来越多的药企在新药研发过程中就着重关注基因毒性杂质的控制和检测。
3哪些化合物是基因毒性杂质杂质的结构多种多样，对于绝⼤多数的杂质⽽⾔，往往没有充分的毒性或致癌研究数据，因⽽难以对其进⾏归类。
CPDB基因毒性杂质列表
A-α-C (CAS 26148-68-5)Acesulfame-K (CAS 55589-62-3)Acetaldehyde (CAS 75-07-0)Acetaldehyde methylformylhydrazone (CAS 16568-02-8) Acetaldoxime (CAS 107-29-9)Acetamide (CAS 60-35-5)Acetaminophen (CAS 103-90-2)Acetohexamide (CAS 968-81-0)Acetone[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazone (CAS 18523-69-8) Acetonitrile (CAS 75-05-8)Acetoxime (CAS 127-06-0)1′-Acetoxysafrole (CAS 34627-78-6)N′-Acetyl-4-(hydroxymethyl)phenylhydrazine (CAS 65734-38-5)1-Acetyl-2-isonicotinoylhydrazine (CAS 1078-38-2)3-Acetyl-6-methyl-2,4-pyrandione (CAS 520-45-6)1-Acetyl-2-phenylhydrazine (CAS 114-83-0)4-Acetylaminobiphenyl (CAS 4075-79-0)1-Acetylaminofluorene (CAS 28314-03-6)2-Acetylaminofluorene (CAS 53-96-3)2,7-Acetylaminofluorene (CAS 304-28-9)4-Acetylaminofluorene (CAS 28322-02-3)4-Acetylaminophenylacetic acid (CAS 18699-02-0)N-Acetylcysteine (CAS 616-91-1) Acifluorfen (CAS 50594-66-6)Acrolein (CAS 107-02-8)Acrolein diethylacetal (CAS 3054-95-3) Acrolein oxime (CAS 5314-33-0) Acronycine (CAS 7008-42-6)Acrylamide (CAS 79-06-1)Acrylic acid (CAS 79-10-7)Acrylonitrile (CAS 107-13-1)Actinomycin C (CAS 8052-16-2) Actinomycin D (CAS 50-76-0)Adipamide (CAS 628-94-4)Adriamycin (CAS 23214-92-8)AF-2 (CAS 3688-53-7)Aflatoxicol (CAS 29611-03-8)Aflatoxin B1(CAS 1162-65-8)Aflatoxin, crude (CAS 1402-68-2)Agar (CAS 9002-18-0)Alclofenac (CAS 22131-79-9)Aldicarb (CAS 116-06-3)Aldrin (CAS 309-00-2) Alkylbenzenesulfonate, linear (CAS 42615-29-2)Alkyldimethylamine oxides, commercial gradeAllantoin (CAS 97-59-6)Allyl alcohol (CAS 107-18-6)Allyl chloride (CAS 107-05-1)Allyl glycidyl ether (CAS 106-92-3)Allyl isothiocyanate (CAS 57-06-7)Allyl isovalerate (CAS 2835-39-4)1-Allyl-1-nitrosourea (CAS 760-56-5)Allylhydrazine.HCl (CAS 52207-83-7)Aluminum potassium sulfate (CAS 10043-67-1)1-Amino-2,4-dibromoanthraquinone (CAS 81-49-2)3-Amino-4-ethoxyacetanilide (CAS 17026-81-2)3-Amino-9-ethylcarbazole.HCl (CAS 6109-97-3)3-Amino-9-ethylcarbazole mixture3-Amino-4-[2-[(2-guanidinothiazol-4-yl)methylthio],ethylamino]-1,2,5-thiadiazole1-Amino-2-methylanthraquinone (CAS 82-28-0)2-Amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole (CAS 3775-55-1)2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole (CAS 712-68-5)2-Amino-4-(5-nitro-2-furyl)thiazole (CAS 38514-71-5)trans-5-Amino-3[2-(5-nitro-2-furyl)vinyl]-1,2,4-oxadiazole (CAS 28754-68-9) 2-Amino-4-nitrophenol (CAS 99-57-0)2-Amino-5-nitrophenol (CAS 121-88-0)4-Amino-2-nitrophenol (CAS 119-34-6)2-Amino-4-(p-nitrophenyl)thiazole (CAS 2104-09-8)2-Amino-5-nitrothiazole (CAS 121-66-4)2-Amino-5-phenyl-2-oxazolin-4-one + Mg(OH)2(CAS 18968-99-5) 2-Aminoanthraquinone (CAS 117-79-3)o-Aminoazotoluene (CAS 97-56-3)6-Aminocaproic acid (CAS 60-32-2)4-Aminodiphenyl (CAS 92-67-1)4-Aminodiphenyl.HCl (CAS 2113-61-3)2-Aminodiphenylene oxide (CAS 3693-22-9)1-(Aminomethyl)cyclohexaneacetic acid (CAS 60142-96-3)2,2′-[(4-Aminophenyl)imino]bisethanol sulfate (CAS 54381-16-7) 3-Aminotriazole (CAS 61-82-5)11-Aminoundecanoic acid (CAS 2432-99-7)Ammonium chloride (CAS 12125-02-9)Ammonium citrate (CAS 3012-65-5)Ammonium hydroxide (CAS 1336-21-6)Amobarbital (CAS 57-43-2)dl-Amphetamine sulfate (CAS 60-13-9)Ampicillin trihydrate (CAS 7177-48-2)1-Amyl-1-nitrosourea (CAS 10589-74-9)Amylopectin sulfate (CAS 9047-13-6)Anethole (CAS 104-46-1)trans-Anethole (CAS 4180-23-8)Anhydroglucochloral (CAS 15879-93-3)Anilazine (CAS 101-05-3)Aniline (CAS 62-53-3)Aniline.HCl (CAS 142-04-1)o-Anisidine.HCl (CAS 134-29-2)p-Anisidine.HCl (CAS 20265-97-8)Anthranilic acid (CAS 118-92-3)9,10-Anthraquinone (CAS 84-65-1)Antimony potassium tartrate (CAS 28300-74-5)Aramite (CAS 140-57-8)Arecoline.HCl (CAS 61-94-9)Aristolochic acid, sodium salt (77% AA I, 21% AA II) (CAS 10190-99-5) Aroclor 1016 (CAS 12674-11-2)Aroclor 1242 (CAS 11104-29-3)Aroclor 1254 (CAS 11097-69-1)Aroclor 1260 (CAS 11096-82-5)Arsenate, sodium (CAS 7631-89-2)Arsenious oxide (CAS 1327-53-3)Arsenite, sodium (CAS 7784-46-5)l-Ascorbate, sodium (CAS 134-03-2)l-Ascorbic acid (CAS 50-81-7)Aspartame (CAS 22839-47-0)Aspirin (CAS 50-78-2)Aspirin, phenacetin, and caffeine (CAS 8003-03-0) Astemizole (CAS 68844-77-9)dl-Atenolol.HCl (CAS 51706-40-2)Atrazine (CAS 1912-24-9)Atropine (CAS 51-55-8)Auramine-O (CAS 2465-27-2)Auranofin (CAS 34031-32-8)5-Azacytidine (CAS 320-67-2)6-Azacytidine (CAS 3131-60-0)Azaserine (CAS 115-02-6)Azathioprine (CAS 446-86-6)Azelnidipine (CAS 123524-52-7)Azide, sodium (CAS 26628-22-8) Azinphosmethyl (CAS 86-50-0) Azobenzene (CAS 103-33-3) Azoxymethane (CAS 25843-45-2)1-Azoxypropane (CAS 17697-55-1)2-Azoxypropane (CAS 17697-53-9)AZT (CAS 30516-87-1)Barbital, sodium (CAS 144-02-5)Barbituric acid (CAS 67-52-7)Barium acetate (CAS 543-80-6)Barium chloride dihydrate (CAS 10326-27-9) Bemitradine (CAS 88133-11-3)Benzalazine (CAS 64896-26-0)Benzaldehyde (CAS 100-52-7)Benzene (CAS 71-43-2)Benzenediazonium sulfate (CAS 6415-38-9) Benzenediazonium tetrafluoroborate (CAS 369-57-3) Benzenesulphonohydrazide (CAS 5351-65-5) Benzidine (CAS 92-87-5)Benzidine.2HCl (CAS 531-85-1)Benzo(a)pyrene (CAS 50-32-8)Benzoate, sodium (CAS 532-32-1)Benzofuran (CAS 271-89-6) Benzoguanamine (CAS 91-76-9)Benzoic acid (CAS 65-85-0)Benzoin (CAS 119-53-9)1,4-Benzoquinone (CAS 106-51-4) Benzothiazyl disulfide (CAS 120-78-5)1H-Benzotriazole (CAS 95-14-7)Benzotrichloride (CAS 98-07-7)Benzoyl hydrazine (CAS 613-94-5)Benzyl acetate (CAS 140-11-4)Benzyl alcohol (CAS 100-51-6)Benzyl chloride (CAS 100-44-7)o-Benzyl-p-chlorophenol (CAS 120-32-1)Benzyl isothiocyanate (CAS 622-78-6)Benzyl thiocyanate (CAS 3012-37-1)Benzylhydrazine.2HCl (CAS 20570-96-1)3-Benzylsydnone-4-acetamide (CAS 14504-15-5)Beryllium sulfate (CAS 13510-49-1)Bifenthrin (CAS 82657-04-3)Biphenyl (CAS 92-52-4)5,5′-(1,1′-Biphenyl)-2,5-dylbis(oxy)(2,2-dimethylpentanoic acid) (CAS 79520-77-7)2-Biphenylamine.HCl (CAS 2185-92-4)2,2-Bis(bromomethyl)-1,3-propanediol, technical grade (CAS 3296-90-0)1,1-Bis(tert-butylperoxy)-3,3,5-trimethylcyclohexane (CAS 6731-36-8)Bis(tri-n-butyltin)oxide, technical grade (CAS 56-35-9)Bis(2-chloro-1-methylethyl)ether, technical grade (CAS 108-60-1)Bis-2-chloroethylether (CAS 111-44-4)Bis-1,4-(chloromethoxy)butane (CAS 13483-19-7)Bis-1,2-(chloromethoxy)ethane (CAS 13483-18-6)Bis-1,6-(chloromethoxy)hexane (CAS 56894-92-9)Bis-1,4-(chloromethoxy)-p-xylene (CAS 56894-91-8)Bis-(chloromethyl)ether (CAS 542-88-1)Bis(2,3-dibromopropyl)phosphate, magnesium salt (CAS 36711-31-6)1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (CAS 76150-91-9)4-Bis(2-hydroxyethyl)amino-2-(5-nitro-2-thienyl)quinazoline (CAS 33372-39-3) 4-Bis(2-hydroxyethyl)amino-2-(2-thienyl)quinazoline (CAS 58139-47-2)Bis-2-hydroxyethyldithiocarbamic acid, potassium (CAS 23746-34-1)Bis(2-hydroxypropyl)amine (CAS 110-97-4)Bismuth dimethyldithiocarbamate (CAS 21260-46-8)Bismuth oxychloride (CAS 7787-59-9)Bisphenol A (CAS 80-05-7)Black PN (CAS 2519-30-4)C.I. direct black 38 (CAS 1937-37-7)C.I. direct blue 6 (CAS 2602-46-2)C.I. direct blue 15 (CAS 2429-74-5)C.I. direct blue 218 (CAS 28407-37-6)C.I. disperse blue 1 (CAS 2475-45-8)FD & C blue no. 1 (CAS 3844-45-9)FD & C blue no. 2 (CAS 860-22-0)HC blue no. 1 (CAS 2784-94-3)HC blue no. 1 (purified) (CAS 2784-94-3)HC blue no. 2 (CAS 33229-34-4)Gardenia blue color (CAS 526194-45-6)Boric acid (CAS 10043-35-3)Bromate, potassium (CAS 7758-01-2) Bromoacetaldehyde (CAS 17157-48-1) Bromocriptine mesylate (CAS 22260-51-1) Bromodichloromethane (CAS 75-27-4) Bromoethane (CAS 74-96-4)Bromoethanol (CAS 540-51-2)C.I. direct brown 95 (CAS 16071-86-6)Budesonide (CAS 51333-22-3)1,3-Butadiene (CAS 106-99-0)2-Butoxyethanol (CAS 111-76-2)tert-Butyl alcohol (CAS 75-65-0)Butyl benzyl phthalate (CAS 85-68-7)n-Butyl chloride (CAS 109-69-3)2-sec-Butyl-4,6-dinitrophenol (CAS 88-85-7)N-n-Butyl-N-formylhydrazine (CAS 16120-70-0)Butyl p-hydroxybenzoate (CAS 94-26-8)N-Butyl-N-(4-hydroxybutyl)nitrosamine (CAS 3817-11-6)di-tert-Butyl-4-hydroxymethyl phenol (CAS 88-26-6)2-tert-Butyl-4-methylphenol (CAS 2409-55-4)N-Butyl-N′-nitro-N-nitrosoguanidine (CAS 13010-08-7) N-n-Butyl-N-nitrosourea (CAS 869-01-2)Butylated hydroxyanisole (CAS 25013-16-5) Butylated hydroxytoluene (CAS 128-37-0)1,1-di-n-Butylhydrazine (CAS 7422-80-2)n-Butylhydrazine.HCl (CAS 56795-65-4)1,2-di-n-Butylhydrazine.2HCl (CAS 78776-28-0)tert-Butylhydroquinone (CAS 1948-33-0)2,4,6-tri-tert-Butylphenol (CAS 732-26-3)p-tert-Butylphenol (CAS 98-54-4)N-Butylurea (CAS 592-31-4)β-Butyrolactone (CAS 3068-88-0)γ-Butyrolactone (CAS 96-48-0)Cadmium acetate (CAS 543-90-8)Cadmium chloride (CAS 10108-64-2)Cadmium chloride monohydrate (CAS 35658-65-2) Cadmium diethyldithiocarbamate (CAS 14239-68-0) Cadmium sulphate (1:1) (CAS 10124-36-4) Cadmium sulphate (1:1) hydrate (3:8) (CAS 7790-84-3) Caffeic acid (CAS 331-39-5)Caffeine (CAS 58-08-2)Calciferol (CAS 50-14-6)Calcium acetate (CAS 62-54-4)Calcium chloride (CAS 10043-52-4) Calcium lactate (CAS 814-80-2)Calcium valproate (CAS 33433-82-8) Camostat mesylate (CAS 59721-29-8) Candesartan cilexetil (CAS 145040-37-5) Caprolactam (CAS 105-60-2)Capsaicin (CAS 404-86-4)Captafol (CAS 2425-06-1)Captan (CAS 133-06-2)Carbamyl hydrazine.HCl (CAS 563-41-7)1-Carbamyl-2-phenylhydrazine (CAS 103-03-7) Carbarsone (CAS 121-59-5)Carbaryl (CAS 63-25-2)Carbazole (CAS 86-74-8)Carbofuran (CAS 1563-66-2)Carbon tetrachloride (CAS 56-23-5) Carboxymethylnitrosourea (CAS 60391-92-6) Carbromal (CAS 77-65-6)β-Carotene (CAS 7235-40-7)Carrageenan, acid-degraded (CAS 53973-98-1)Carrageenan, native (CAS 9000-07-1)d-Carvone (CAS 2244-16-8)Catechins, commercial mixture from green tea (91% catechins) (CAS 136511-29-0)Catechol (CAS 120-80-9)Celecoxib (CAS 169590-42-5)Celiprolol (CAS 56980-93-9)Cevimeline.HCl (CAS 153504-70-2)Chenodeoxycholic acid (CAS 474-25-9)Chloral hydrate (CAS 302-17-0)Chloramben (CAS 133-90-4)Chlorambucil (CAS 305-03-3)Chloraminated waterChloramphenicol (CAS 56-75-7)Chloranil (CAS 118-75-2)Chlordane, technical grade (CAS 57-74-9)Chlorendic acid (CAS 115-28-6)Chlorinated paraffins (C12, 60% chlorine) (CAS 63449-39-8)Chlorinated paraffins (C23, 43% chlorine) (CAS 63449-39-8)Chlorinated trisodium phosphate (CAS 32680-25-4)Chlorinated waterChlorine (CAS 7782-50-5)Chlormadinone acetate (CAS 302-22-7)4-Chloro-4′-aminodiphenylether (CAS 101-79-1)3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (CAS 77439-76-0)2-Chloro-5-(3,5-dimethylpiperidinosulphonyl)benzoic acid (CAS 37087-94-8) 1-Chloro-2,4-dinitrobenzene (CAS 97-00-7)3-Chloro-2-methylpropene (CAS 563-47-3)3-Chloro-2-methylpropene, technical grade (containing 5% dimethylvinyl chloride) (CAS 563-47-3)1-Chloro-2-nitrobenzene (CAS 88-73-3)1-Chloro-4-nitrobenzene (CAS 100-00-5)4-Chloro-m-phenylenediamine (CAS 5131-60-2)4-Chloro-o-phenylenediamine (CAS 95-83-0)2-Chloro-p-phenylenediamine sulfate (CAS 61702-44-1)1-Chloro-2-propanol, technical grade (~75% 1-chloro-2-propanol; ~25% 2-chloro-1-propanol) (CAS 127-00-4)3-Chloro-p-toluidine (CAS 95-74-9)5-Chloro-o-toluidine (CAS 95-79-4)4-Chloro-o-toluidine.HCl (CAS 3165-93-3)2-Chloro-1,1,1-trifluoroethane (CAS 75-88-7)[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (CAS 50892-23-4)4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio(N-β-hydroxyethyl)acetamide (CAS65089-17-0)Chloroacetaldehyde (CAS 107-20-0)2-Chloroacetophenone (CAS 532-27-4)4′-(Chloroacetyl)-acetanilide (CAS 140-49-8)p-Chloroaniline (CAS 106-47-8)p-Chloroaniline.HCl (CAS 20265-96-7)o-Chlorobenzalmalonitrile (CAS 2698-41-1)Chlorobenzene (CAS 108-90-7)Chlorobenzilate (CAS 510-15-6)Chlorodibromomethane (CAS 124-48-1)Chlorodifluoromethane (CAS 75-45-6)Chloroethane (CAS 75-00-3)(2-Chloroethyl)trimethylammonium chloride (CAS 999-81-5)1-Chloroethylnitroso-3-(2-hydroxypropyl)ureaChlorofluoromethane (CAS 593-70-4)Chloroform (CAS 67-66-3)Chloromethyl methyl ether (CAS 107-30-2)2-(Chloromethyl)pyridine.HCl (CAS 6959-47-3)3-(Chloromethyl)pyridine.HCl (CAS 6959-48-4)p-Chlorophenyl-p-chlorobenzene sulfonate (CAS 80-33-1)3-(p-Chlorophenyl)-1,1-dimethylurea (CAS 150-68-5)(±)-(4)-(2-Chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine (CAS 117279-73-9)1-(4-Chlorophenyl)-1-phenyl-2-propynyl carbamate (CAS 10473-70-8) p-Chlorophenyl-2,4,5-trichlorophenyl sulfide (CAS 2227-13-6) Chloropicrin (CAS 76-06-2)Chloroprene (>96% chloroprene) (CAS 126-99-8)Chloroprene (99.6% chloroprene) (CAS 126-99-8)2-Chloropropanal (CAS 683-50-1)1-Chloropropene (CAS 590-21-6)Chlorotetrafluoroethane (CAS 2837-89-0)Chlorothalonil (CAS 1897-45-6)Chlorozotocin (CAS 54749-90-5)Chlorpheniramine maleate (CAS 113-92-8)Chlorpropamide (CAS 94-20-2)Chocolate Brown FB (CAS 12236-46-3)Chocolate Brown HT (CAS 4553-89-3)Choline chloride (CAS 67-48-1)Chromic oxide pigment (CAS 1308-38-9)Chromium (III) acetate (CAS 1066-30-4)Chrysazin (CAS 117-10-2)Cimetidine (CAS 51481-61-9)trans-Cinnamaldehyde (CAS 14371-10-9)Cinnamyl anthranilate (CAS 87-29-6)Ciprofibrate (CAS 52214-84-3)Citral (CAS 5392-40-5)Citric acid (CAS 77-92-9)Citrinin (CAS 518-75-2)Clivorine (CAS 33979-15-6)Clobuzarit (CAS 22494-47-9)Clofibrate (CAS 637-07-0)Clomiphene citrate (CAS 43054-45-1) Clonitralid (CAS 1420-04-8)Clophen A 30 (CAS 55600-34-5)Cobalt sulfate heptahydrate (CAS 10026-24-1) Codeine (CAS 76-57-3)Colcemid (CAS 477-30-5)Compound 50-892 (CAS 65765-07-3) Compound LY171883 (CAS 88107-10-2) Copper dimethyldithiocarbamate (CAS 137-29-1) Copper-8-hydroxyquinoline (CAS 10380-28-6) Coumaphos (CAS 56-72-4)Coumarin (CAS 91-64-5)m-Cresidine (CAS 102-50-1)p-Cresidine (CAS 120-71-8) Crotonaldehyde (CAS 123-73-9)Cupferron (CAS 135-20-6)Cyanamide, calcium (CAS 156-62-7)Cyanazine (CAS 21725-46-2)Cyanoguanidine (CAS 157480-33-6)Cycasin and methylazoxymethanol acetateCyclamate, sodium (CAS 139-05-9)Cyclochlorotine (CAS 12663-46-6)Cyclocytidine (CAS 31698-14-3)β-Cyclodextrin (CAS 7585-39-9)Cyclohexanone (CAS 108-94-1)N-Cyclohexyl-2-benzothiazole sulfenamide (CAS 95-33-0) Cyclohexylamine.HCl (CAS 4998-76-9)Cyclohexylamine sulfate (CAS 19834-02-7)Cyclopentanone oxime (CAS 1192-28-5)3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide (CAS 144035-83-6)Cyclophosphamide (CAS 50-18-0)Cyclosporin A (CAS 59865-13-3)Cyproterone acetate (CAS 427-51-0)l-Cysteine.HCl (CAS 52-89-1)Cytembena (CAS 16170-75-5)Dacarbazine (CAS 4342-03-4)Daminozide (CAS 1596-84-5)Dapsone (CAS 80-08-0)o,p′-DDD (CAS 53-19-0)p,p′-DDD (CAS 72-54-8)p,p′-DDE (CAS 72-55-9)DDT (CAS 50-29-3)Decabromodiphenyl oxide (CAS 1163-19-5)Decabromodiphenyl oxide, technical grade (77.4% DBDPO, 21.8% nonabromodiphenyl oxide, 0.8% octabromodiphenyl oxide) (CAS 1163-19-5) Deflazacort (CAS 14484-47-0)Dehydroepiandrosterone (CAS 53-43-0)Dehydroepiandrosterone acetate (CAS 853-23-6) Dehydroepiandrosterone sulfate (CAS 651-48-9)Deltamethrin (CAS 52918-63-5)Deoxynivalenol (CAS 51481-10-8)Deserpidine (CAS 131-01-1)Dexamethazone (CAS 50-02-2)Dextran (CAS 9004-54-0)Dextran sulfate sodium (DS-M-1) (CAS 9011-18-1)Dextran sulfate sodium (DST-H) (CAS 9011-18-1)Dextran sulfate sodium (KMDS-H) (CAS 9011-18-1)N-1-Diacetamidofluorene (CAS 63019-65-8)Diacetyl hydrazine (CAS 3148-73-0)Diallate (CAS 2303-16-4)Diallyl phthalate (CAS 131-17-9)1,1-Diallylhydrazine (CAS 5164-11-4)1,2-Diallylhydrazine.2HCl (CAS 26072-78-6)Diallylnitrosamine (CAS 16338-97-9)4,6-Diamino-2-(5-nitro-2-furyl)-S-triazine (CAS 720-69-4)4,4′-Diamino-2,2′-stilbenedisulfonic acid, disodium salt (CAS 7336-20-1) 2,4-Diaminoanisole sulfate (CAS 39156-41-7)4,4′-Diaminoazobenzene (CAS 538-41-0)4,4′-Diaminobenzanilide (CAS 785-30-8)2,4-Diaminophenol.2HCl (CAS 137-09-7)2,4-Diaminotoluene (CAS 95-80-7)2,4-Diaminotoluene.2HCl (CAS 636-23-7)2,6-Diaminotoluene.2HCl (CAS 15481-70-6)2,5-Diaminotoluene sulfate (CAS 6369-59-1)Diazepam (CAS 439-14-5)Diazinon (CAS 333-41-5)3-Diazotyramine.HClDibenz(a,h)anthracene (CAS 53-70-3)Dibenzo-p-dioxin (CAS 262-12-4)3-Dibenzofuranamine (CAS 4106-66-5)O,S-Dibenzoyl thiamine.HCl (CAS 35660-60-7)1,2-Dibromo-3-chloropropane (CAS 96-12-8)Dibromodulcitol (CAS 10318-26-0)1,2-Dibromoethane (CAS 106-93-4)Dibromomannitol (CAS 488-41-5)5,7-Dibromoquinoline (CAS 34522-69-5)1,3-Dibutyl-1-nitrosourea (CAS 56654-52-5)Dibutyltin diacetate (CAS 1067-33-0)3,5-Dichloro(N-1,1-dimethyl-2-propynyl)benzamide (CAS 23950-58-5) 2,3-Dichloro-p-dioxane (CAS 3883-43-0)1,1-Dichloro-1-fluoroethane (CAS 1717-00-6)α,β-Dichloro-β-formylacrylic acid (CAS 87-56-9)3,4′-Dichloro-2-methylacrylanilide (CAS 2164-09-2)2,3-Dichloro-1,4-naphthoquinone (CAS 117-80-6)2,6-Dichloro-4-nitroaniline (CAS 99-30-9)2,6-Dichloro-p-phenylenediamine (CAS 609-20-1) Dichloroacetic acid (CAS 79-43-6)Dichloroacetylene (CAS 7572-29-4)1,2-Dichlorobenzene (CAS 95-50-1)1,4-Dichlorobenzene (CAS 106-46-7)3,3′-Dichlorobenzidine (CAS 91-94-1)3,3′-Dichlorobenzidine.2HCl (CAS 612-83-9)1,4-Dichlorobutene-2 (65% trans-, 35% cis-) (CAS 764-41-0) trans-1,4-Dichlorobutene-2 (CAS 110-57-6)2,7-Dichlorodibenzo-p-dioxin (CAS 33857-26-0) Dichlorodifluoromethane (CAS 75-71-8)p,p′-Dichlorodiphenyl sulfone (CAS 80-07-9)1,1-Dichloroethane (CAS 75-34-3)1,2-Dichloroethane (CAS 107-06-2)2,4-Dichlorophenol (CAS 120-83-2)α-(2,4-Dichlorophenoxy)propionic acid (CAS 120-36-5)α-(2,5-Dichlorophenoxy)propionic acid (CAS 6965-71-5)2,4-Dichlorophenoxyacetic acid (CAS 94-75-7)2,4-Dichlorophenoxyacetic acid,n-butyl ester (CAS 94-80-4) 2,4-Dichlorophenoxyacetic acid, isooctyl ester (CAS 25168-26-7) 2,4-Dichlorophenoxyacetic acid, isopropyl ester (CAS 94-11-1) 3-(3,4-Dichlorophenyl)-1,1-dimethylurea (CAS 330-54-1)2,4-Dichlorophenylbenzene sulfonate (CAS 97-16-5)1,2-Dichloropropane (CAS 78-87-5)Dichlorvos (CAS 62-73-7)Dichromate, sodium (CAS 10588-01-9)Dicofol (CAS 115-32-2)N,N′-Dicyclohexylthiourea (CAS 1212-29-9) Dicyclopentadiene dioxide (CAS 81-21-0)Dieldrin (CAS 60-57-1)Dieldrin, photo- (CAS 13366-73-9)d,l-Diepoxybutane (CAS 298-18-0)Diethyl-β,γ-epoxypropylphosphonate (CAS 7316-37-2)N,N-Diethyl-4-(4′-[pyridyl-1′-oxide]azo)aniline (CAS 7347-49-1)N,N-Diethyl-m-toluamide (CAS 134-62-3)O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothioate (CAS 2921-88-2) Diethylacetamide (CAS 685-91-6)Diethylacetylurea(±)-4-Diethylamino-1, 1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-phenylacetate.HCl monohydrateDiethylene glycol (CAS 111-46-6)Diethylformamide (CAS 617-84-5)Diethylmaleate (CAS 141-05-9)Diethylstilbestrol (CAS 56-53-1)N,N′-Diethylthiourea (CAS 105-55-5)2-(Difluoromethyl)-dl-ornithine (CAS 70052-12-9)1,2-Diformylhydrazine (CAS 628-36-4)Diftalone (CAS 21626-89-1)Diglycidyl resorcinol ether, technical grade (CAS 101-90-6)5,6-Dihydro-5-azacytidine (CAS 62488-57-7)1,2-Dihydro-2-(5-nitro-2-thienyl)quinazolin-4(3H)-one (CAS 33389-33-2)3,6-Dihydro-2-nitroso-2H-1,2-oxazine (CAS 3276-41-3)3,4-Dihydrocoumarin (CAS 119-84-6)Dihydrosafrole (CAS 94-58-6)3,3′-Dihydroxybenzidine.2HCl (CAS 1592-36-5)24R,25-Dihydroxyvitamin D3 (CAS 55721-11-4)Diisononyl phthalate (CAS 68515-48-0)(R,R)-Dilevalol.HCl (CAS 75659-08-4)Dimethadione (CAS 695-53-4)Dimethoate (CAS 60-51-5)Dimethoxane (CAS 828-00-2)Dimethoxane, commercial grade (CAS 828-00-2)2,5-Dimethoxy-4′-aminostilbene (CAS 5803-51-0)2,4-Dimethoxyaniline.HCl (CAS 54150-69-5)3,3′-Dimethoxybenzidine-4,4′-diisocyanate (CAS 91-93-0)3,3′-Dimethoxybenzidine.2HCl (CAS 20325-40-0)5,7-Dimethoxycyclopentene[c]coumarin (CAS 1146-71-0)5,7-Dimethoxycyclopentenone[2,3-c]coumarin (CAS 1150-37-4)5,7-Dimethoxycyclopentenone[3,2-c]coumarin (CAS 1150-42-1)5,6-Dimethoxysterigmatocystin (CAS 65176-75-2)O,O-Dimethyl S-2(acetylamino)ethyl dithiophosphate, technical grade (CAS 13265-60-6)N,N-Dimethyl-4-aminoazobenzene (CAS 60-11-7)N,N′-Dimethyl-N,N′-dinitrosophthalamide (CAS 3851-16-9)Dimethyl hydrogen phosphite (CAS 868-85-9)Dimethyl methylphosphonate (CAS 756-79-6)Dimethyl morpholinophosphoramidate (CAS 597-25-1)4,6-Dimethyl-2-(5-nitro-2-furyl)pyrimidine (CAS 59-35-8)1,2-Dimethyl-5-nitroimidazole (CAS 551-92-8)Dimethyl terephthalate (CAS 120-61-6)Dimethylacetamide (CAS 127-19-5)6-Dimethylamino-4,4-diphenyl-3-heptanol acetate.HCl (CAS 43033-72-3)6-Dimethylamino-4,4-diphenyl-3-heptanone.HCl (CAS 1095-90-5)trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadia zole (CAS 55738-54-0)4-Dimethylamino-3,5-xylenol (CAS 6120-10-1)4-Dimethylaminoantipyrine (CAS 58-15-1)2-Dimethylaminoethanol (CAS 108-01-0) Dimethylaminoethylnitrosoethylurea, nitrite salt (CAS 142713-78-8)2,6-Dimethylaniline (CAS 87-62-7)N,N-Dimethylaniline (CAS 121-69-7)Dimethylarsinic acid (CAS 75-60-5)5,5-Dimethylbarbituric acid (CAS 24448-94-0)7,12-Dimethylbenz(a)anthracene (CAS 57-97-6)3,3′-Dimethylbenzidine.2HCl (CAS 612-82-8)Dimethylcarbamyl chloride (CAS 79-44-7)Dimethyldithiocarbamic acid, dimethylamine (CAS 598-64-1)N,N-Dimethyldodecylamine-N-oxide (CAS 1643-20-5) Dimethylformamide (CAS 68-12-2)1,1-Dimethylhydrazine (CAS 57-14-7)1,2-Dimethylhydrazine.2HCl (CAS 306-37-6)2-(2,2-Dimethylhydrazino)-4-(5-nitro-2-furyl)thiazole (CAS 26049-69-4) Dimethylnitramine (CAS 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110-00-9)Furfural (CAS 98-01-1)Furfuryl alcohol (CAS 98-00-0)Furosemide (CAS 54-31-9)Fusarenon-X (CAS 23255-69-8)Gallic acid (CAS 149-91-7)Gemcadiol (CAS 35449-36-6)Gemfibrozil (CAS 25812-30-0)Gentian violet (CAS 548-62-9)Geranyl acetate, food grade (71% geranyl acetate, 29% citronellyl acetate) Germanate, sodium (CAS 12025-19-3)。
基因毒性杂质控制相关文件及指南介绍
2016-11-27字体大小：基因毒性杂质控制相关文件及指南介绍【基因毒性杂质控制相关文件及指南介绍】遗传毒性杂质控制指南PhRMA 意见书：测定、检验和控制药物中特定潜在遗传毒性杂质的基本原理 (2006)EMA：遗传毒性杂质限度指南EMA 安全工作组 (SWP)：关于遗传毒性杂质限量指南的问答FDA 行业指南（草案）：原料药和成品药中遗传毒性和致癌性杂质：推荐方法 (2008)。
ICH M7：诱变性杂质评估和控制遗传毒性试验指南ICH S2：人用药物的遗传毒性试验和数据解释EMA：草药物质/制剂遗传毒性评估指南 (2008)遗传毒性和致癌性物质的风险评估欧盟委员会健康与消费者保护局：遗传毒性和致癌性物质一般风险评估的方法学和途径 (2009)EMA ：2006 年首先颁布了《基因毒性杂质限度指南》，并自 2007 年 1 月 1 日起正式实施。
该指南为限制新活性物质中的基因毒性杂质提供了解决问题的框架和具体做法。
弥补了 ICH Q3 不足。
引入了毒理学关注阈值 (TTC) 的概念及其取值。
提出了遗传毒性杂质可接受性评估的决策树。
FDA ：2008 年 12 月正式签发：原料药和成品药中遗传毒性和致癌性杂质，推荐方法。
主要内容包括：• 原料药和制剂中的基因毒性杂质生成的预防办法• 基因毒性杂质的分析方法、处理方法和减少方法• 上市申请和临床研究申请的可接受限度• 草药原料药和制剂中基因毒性杂质评估指南FDA 和 EMA 指南的比较相似点不同点推荐的鉴定和认证潜在遗传性杂质的方法相同 推荐的处理遗传毒性和致癌性杂质的方法相同FDA 指南包含致癌性杂质TTC 设定为 1.5 μg/天指南允许的 14 天内用药的 TTC 水平为 120 μg ， 而非仅针对单次用药临床试验中短期暴露的 TTC 更高FDA 指南不允许根据现售药品的短期暴露情况而 提高 TTC ICH M7【基因毒性杂质的控制策略】具有阳性致癌数据的诱变杂质（第1类）---计算可接受摄入量（ AI ）： • M7 Addendum 中列出的 15 种化合物中有 10 个为该计算方法计算 • Carcinogenicity Potency Database (CPDB ）中列明了 1574 种致癌物质的 TD50 值毒理学关注门槛---TTC 法(第 2/3 类)： • ICHM7 主要讨论的方法，主要针对第 2/3 类基因毒性杂质，比如低级磺酸酯类等。
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531-85-1)Benzo(a)pyrene (CAS 50-32-8)Benzoate, sodium (CAS 532-32-1)Benzofuran (CAS 271-89-6)Benzoguanamine (CAS 91-76-9)Benzoic acid (CAS 65-85-0)Benzoin (CAS 119-53-9)1,4-Benzoquinone (CAS 106-51-4)Benzothiazyl disulfide (CAS 120-78-5)1H-Benzotriazole (CAS 95-14-7)Benzotrichloride (CAS 98-07-7)Benzoyl hydrazine (CAS 613-94-5)Benzyl acetate (CAS 140-11-4)Benzyl alcohol (CAS 100-51-6)Benzyl chloride (CAS 100-44-7)o-Benzyl-p-chlorophenol (CAS 120-32-1)Benzyl isothiocyanate (CAS 622-78-6)Benzyl thiocyanate (CAS 3012-37-1)Benzylhydrazine.2HCl (CAS 20570-96-1)3-Benzylsydnone-4-acetamide (CAS 14504-15-5)Beryllium sulfate (CAS 13510-49-1)Bifenthrin (CAS 82657-04-3)Biphenyl (CAS 92-52-4)5,5′-(1,1′-Biphenyl)-2,5-dylbis(oxy)(2,2-dimethylpentanoic acid) (CAS 79520-77-7)2-Biphenylamine.HCl (CAS 2185-92-4)2,2-Bis(bromomethyl)-1,3-propanediol, technical grade (CAS 3296-90-0) 1,1-Bis(tert-butylperoxy)-3,3,5-trimethylcyclohexane (CAS 6731-36-8) Bis(tri-n-butyltin)oxide, technical grade (CAS 56-35-9)Bis(2-chloro-1-methylethyl)ether, technical grade (CAS 108-60-1)Bis-2-chloroethylether (CAS 111-44-4)Bis-1,4-(chloromethoxy)butane (CAS 13483-19-7)Bis-1,2-(chloromethoxy)ethane (CAS 13483-18-6)Bis-1,6-(chloromethoxy)hexane (CAS 56894-92-9)Bis-1,4-(chloromethoxy)-p-xylene (CAS 56894-91-8)Bis-(chloromethyl)ether (CAS 542-88-1)Bis(2,3-dibromopropyl)phosphate, magnesium salt (CAS 36711-31-6) 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (CAS 76150-91-9)4-Bis(2-hydroxyethyl)amino-2-(5-nitro-2-thienyl)quinazoline (CAS 33372-39-3)4-Bis(2-hydroxyethyl)amino-2-(2-thienyl)quinazoline (CAS 58139-47-2) Bis-2-hydroxyethyldithiocarbamic acid, potassium (CAS 23746-34-1) Bis(2-hydroxypropyl)amine (CAS 110-97-4)Bismuth dimethyldithiocarbamate (CAS 21260-46-8)Bismuth oxychloride (CAS 7787-59-9)Bisphenol A (CAS 80-05-7)Black PN (CAS 2519-30-4)C.I. direct black 38 (CAS 1937-37-7)C.I. direct blue 6 (CAS 2602-46-2)C.I. direct blue 15 (CAS 2429-74-5)C.I. direct blue 218 (CAS 28407-37-6)C.I. disperse blue 1 (CAS 2475-45-8)FD & C blue no. 1 (CAS 3844-45-9)FD & C blue no. 2 (CAS 860-22-0)HC blue no. 1 (CAS 2784-94-3)HC blue no. 1 (purified) (CAS 2784-94-3)HC blue no. 2 (CAS 33229-34-4)Gardenia blue color (CAS 526194-45-6)Boric acid (CAS 10043-35-3)Bromate, potassium (CAS 7758-01-2)Bromoacetaldehyde (CAS 17157-48-1)Bromocriptine mesylate (CAS 22260-51-1)Bromodichloromethane (CAS 75-27-4)Bromoethane (CAS 74-96-4)Bromoethanol (CAS 540-51-2)C.I. direct brown 95 (CAS 16071-86-6)Budesonide (CAS 51333-22-3)1,3-Butadiene (CAS 106-99-0)2-Butoxyethanol (CAS 111-76-2)tert-Butyl alcohol (CAS 75-65-0)Butyl benzyl phthalate (CAS 85-68-7)n-Butyl chloride (CAS 109-69-3)2-sec-Butyl-4,6-dinitrophenol (CAS 88-85-7)N-n-Butyl-N-formylhydrazine (CAS 16120-70-0)Butyl p-hydroxybenzoate (CAS 94-26-8)N-Butyl-N-(4-hydroxybutyl)nitrosamine (CAS 3817-11-6) di-tert-Butyl-4-hydroxymethyl phenol (CAS 88-26-6)2-tert-Butyl-4-methylphenol (CAS 2409-55-4)N-Butyl-N′-nitro-N-nitrosoguanidine (CAS 13010-08-7) N-n-Butyl-N-nitrosourea (CAS 869-01-2)Butylated hydroxyanisole (CAS 25013-16-5)Butylated hydroxytoluene (CAS 128-37-0)1,1-di-n-Butylhydrazine (CAS 7422-80-2)n-Butylhydrazine.HCl (CAS 56795-65-4)1,2-di-n-Butylhydrazine.2HCl (CAS 78776-28-0)tert-Butylhydroquinone (CAS 1948-33-0)2,4,6-tri-tert-Butylphenol (CAS 732-26-3)p-tert-Butylphenol (CAS 98-54-4)N-Butylurea (CAS 592-31-4)β-Butyrolactone (CAS 3068-88-0)γ-Butyrolactone (CAS 96-48-0)Cadmium acetate (CAS 543-90-8)Cadmium chloride (CAS 10108-64-2)Cadmium chloride monohydrate (CAS 35658-65-2) Cadmium diethyldithiocarbamate (CAS 14239-68-0) Cadmium sulphate (1:1) (CAS 10124-36-4)Cadmium sulphate (1:1) hydrate (3:8) (CAS 7790-84-3) Caffeic acid (CAS 331-39-5)Caffeine (CAS 58-08-2)Calciferol (CAS 50-14-6)Calcium acetate (CAS 62-54-4)Calcium chloride (CAS 10043-52-4)Calcium lactate (CAS 814-80-2)Calcium valproate (CAS 33433-82-8)Camostat mesylate (CAS 59721-29-8)Candesartan cilexetil (CAS 145040-37-5)Caprolactam (CAS 105-60-2)Capsaicin (CAS 404-86-4)Captafol (CAS 2425-06-1)Captan (CAS 133-06-2)Carbamyl hydrazine.HCl (CAS 563-41-7)1-Carbamyl-2-phenylhydrazine (CAS 103-03-7) Carbarsone (CAS 121-59-5)Carbaryl (CAS 63-25-2)Carbazole (CAS 86-74-8)Carbofuran (CAS 1563-66-2)Carbon tetrachloride (CAS 56-23-5) Carboxymethylnitrosourea (CAS 60391-92-6)Carbromal (CAS 77-65-6)β-Carotene (CAS 7235-40-7)Carrageenan, acid-degraded (CAS 53973-98-1)Carrageenan, native (CAS 9000-07-1)d-Carvone (CAS 2244-16-8)Catechins, commercial mixture from green tea (91% catechins) (CAS 136511-29-0)Catechol (CAS 120-80-9)Celecoxib (CAS 169590-42-5)Celiprolol (CAS 56980-93-9)Cevimeline.HCl (CAS 153504-70-2)Chenodeoxycholic acid (CAS 474-25-9)Chloral hydrate (CAS 302-17-0)Chloramben (CAS 133-90-4)Chlorambucil (CAS 305-03-3)Chloraminated waterChloramphenicol (CAS 56-75-7)Chloranil (CAS 118-75-2)Chlordane, technical grade (CAS 57-74-9)Chlorendic acid (CAS 115-28-6)Chlorinated paraffins (C12, 60% chlorine) (CAS 63449-39-8) Chlorinated paraffins (C23, 43% chlorine) (CAS 63449-39-8) Chlorinated trisodium phosphate (CAS 32680-25-4)Chlorinated waterChlorine (CAS 7782-50-5)Chlormadinone acetate (CAS 302-22-7)4-Chloro-4′-aminodiphenylether (CAS 101-79-1)3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (CAS 77439-76-0)2-Chloro-5-(3,5-dimethylpiperidinosulphonyl)benzoic acid (CAS 37087-94-8)1-Chloro-2,4-dinitrobenzene (CAS 97-00-7)3-Chloro-2-methylpropene (CAS 563-47-3)3-Chloro-2-methylpropene, technical grade (containing 5% dimethylvinyl chloride) (CAS 563-47-3)1-Chloro-2-nitrobenzene (CAS 88-73-3)1-Chloro-4-nitrobenzene (CAS 100-00-5)4-Chloro-m-phenylenediamine (CAS 5131-60-2)4-Chloro-o-phenylenediamine (CAS 95-83-0)2-Chloro-p-phenylenediamine sulfate (CAS 61702-44-1)1-Chloro-2-propanol, technical grade (~75% 1-chloro-2-propanol; ~25% 2-chloro-1-propanol) (CAS 127-00-4)3-Chloro-p-toluidine (CAS 95-74-9)5-Chloro-o-toluidine (CAS 95-79-4)4-Chloro-o-toluidine.HCl (CAS 3165-93-3)2-Chloro-1,1,1-trifluoroethane (CAS 75-88-7)[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (CAS 50892-23-4)4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio(N-β-hydroxyethyl)acetamide (CAS 65089-17-0)Chloroacetaldehyde (CAS 107-20-0)2-Chloroacetophenone (CAS 532-27-4)4′-(Chloroacetyl)-acetanilide (CAS 140-49-8)p-Chloroaniline (CAS 106-47-8)p-Chloroaniline.HCl (CAS 20265-96-7)o-Chlorobenzalmalonitrile (CAS 2698-41-1)Chlorobenzene (CAS 108-90-7)Chlorobenzilate (CAS 510-15-6)Chlorodibromomethane (CAS 124-48-1)Chlorodifluoromethane (CAS 75-45-6)Chloroethane (CAS 75-00-3)(2-Chloroethyl)trimethylammonium chloride (CAS 999-81-5)1-Chloroethylnitroso-3-(2-hydroxypropyl)urea Chlorofluoromethane (CAS 593-70-4)Chloroform (CAS 67-66-3)Chloromethyl methyl ether (CAS 107-30-2)2-(Chloromethyl)pyridine.HCl (CAS 6959-47-3)3-(Chloromethyl)pyridine.HCl (CAS 6959-48-4)p-Chlorophenyl-p-chlorobenzene sulfonate (CAS 80-33-1)3-(p-Chlorophenyl)-1,1-dimethylurea (CAS 150-68-5)(±)-(4)-(2-Chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine (CAS 117279-73-9)1-(4-Chlorophenyl)-1-phenyl-2-propynyl carbamate (CAS 10473-70-8) p-Chlorophenyl-2,4,5-trichlorophenyl sulfide (CAS 2227-13-6) Chloropicrin (CAS 76-06-2)Chloroprene (>96% chloroprene) (CAS 126-99-8)Chloroprene (99.6% chloroprene) (CAS 126-99-8)2-Chloropropanal (CAS 683-50-1)1-Chloropropene (CAS 590-21-6)Chlorotetrafluoroethane (CAS 2837-89-0)Chlorothalonil (CAS 1897-45-6)Chlorozotocin (CAS 54749-90-5)Chlorpheniramine maleate (CAS 113-92-8)Chlorpropamide (CAS 94-20-2)Chocolate Brown FB (CAS 12236-46-3)Chocolate Brown HT (CAS 4553-89-3)Choline chloride (CAS 67-48-1)Chromic oxide pigment (CAS 1308-38-9)Chromium (III) acetate (CAS 1066-30-4)Chrysazin (CAS 117-10-2)Cimetidine (CAS 51481-61-9)trans-Cinnamaldehyde (CAS 14371-10-9)Cinnamyl anthranilate (CAS 87-29-6)Ciprofibrate (CAS 52214-84-3)Citral (CAS 5392-40-5)Citric acid (CAS 77-92-9)Citrinin (CAS 518-75-2)Clivorine (CAS 33979-15-6)Clobuzarit (CAS 22494-47-9)Clofibrate (CAS 637-07-0)Clomiphene citrate (CAS 43054-45-1)Clonitralid (CAS 1420-04-8)Clophen A 30 (CAS 55600-34-5)Cobalt sulfate heptahydrate (CAS 10026-24-1)Codeine (CAS 76-57-3)Colcemid (CAS 477-30-5)Compound 50-892 (CAS 65765-07-3)Compound LY171883 (CAS 88107-10-2)Copper dimethyldithiocarbamate (CAS 137-29-1)Copper-8-hydroxyquinoline (CAS 10380-28-6)Coumaphos (CAS 56-72-4)Coumarin (CAS 91-64-5)m-Cresidine (CAS 102-50-1)p-Cresidine (CAS 120-71-8)Crotonaldehyde (CAS 123-73-9)Cupferron (CAS 135-20-6)Cyanamide, calcium (CAS 156-62-7)Cyanazine (CAS 21725-46-2)Cyanoguanidine (CAS 157480-33-6)Cycasin and methylazoxymethanol acetateCyclamate, sodium (CAS 139-05-9)Cyclochlorotine (CAS 12663-46-6)Cyclocytidine (CAS 31698-14-3)β-Cyclodextrin (CAS 7585-39-9)Cyclohexanone (CAS 108-94-1)N-Cyclohexyl-2-benzothiazole sulfenamide (CAS 95-33-0) Cyclohexylamine.HCl (CAS 4998-76-9)Cyclohexylamine sulfate (CAS 19834-02-7)Cyclopentanone oxime (CAS 1192-28-5)3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide (CAS 144035-83-6)Cyclophosphamide (CAS 50-18-0)Cyclosporin A (CAS 59865-13-3)Cyproterone acetate (CAS 427-51-0)l-Cysteine.HCl (CAS 52-89-1)Cytembena (CAS 16170-75-5)Dacarbazine (CAS 4342-03-4)Daminozide (CAS 1596-84-5)Dapsone (CAS 80-08-0)o,p′-DDD (CAS 53-19-0)p,p′-DDD (CAS 72-54-8)p,p′-DDE (CAS 72-55-9)DDT (CAS 50-29-3)Decabromodiphenyl oxide (CAS 1163-19-5)Decabromodiphenyl oxide, technical grade (77.4% DBDPO, 21.8% nonabromodiphenyl oxide, 0.8% octabromodiphenyl oxide) (CAS 1163-19-5)Deflazacort (CAS 14484-47-0)Dehydroepiandrosterone (CAS 53-43-0)Dehydroepiandrosterone acetate (CAS 853-23-6) Dehydroepiandrosterone sulfate (CAS 651-48-9)Deltamethrin (CAS 52918-63-5)Deoxynivalenol (CAS 51481-10-8)Deserpidine (CAS 131-01-1)Dexamethazone (CAS 50-02-2)Dextran (CAS 9004-54-0)Dextran sulfate sodium (DS-M-1) (CAS 9011-18-1)Dextran sulfate sodium (DST-H) (CAS 9011-18-1)Dextran sulfate sodium (KMDS-H) (CAS 9011-18-1)N-1-Diacetamidofluorene (CAS 63019-65-8)Diacetyl hydrazine (CAS 3148-73-0)Diallate (CAS 2303-16-4)Diallyl phthalate (CAS 131-17-9)1,1-Diallylhydrazine (CAS 5164-11-4)1,2-Diallylhydrazine.2HCl (CAS 26072-78-6)Diallylnitrosamine (CAS 16338-97-9)4,6-Diamino-2-(5-nitro-2-furyl)-S-triazine (CAS 720-69-4)4,4′-Diamino-2,2′-stilbenedisulfonic acid, disodium salt (CAS 7336-20-1) 2,4-Diaminoanisole sulfate (CAS 39156-41-7)4,4′-Diaminoazobenzene (CAS 538-41-0)4,4′-Diaminobenzanilide (CAS 785-30-8)2,4-Diaminophenol.2HCl (CAS 137-09-7)2,4-Diaminotoluene (CAS 95-80-7)2,4-Diaminotoluene.2HCl (CAS 636-23-7)2,6-Diaminotoluene.2HCl (CAS 15481-70-6)2,5-Diaminotoluene sulfate (CAS 6369-59-1)Diazepam (CAS 439-14-5)Diazinon (CAS 333-41-5)3-Diazotyramine.HClDibenz(a,h)anthracene (CAS 53-70-3)Dibenzo-p-dioxin (CAS 262-12-4)3-Dibenzofuranamine (CAS 4106-66-5)O,S-Dibenzoyl thiamine.HCl (CAS 35660-60-7)1,2-Dibromo-3-chloropropane (CAS 96-12-8)Dibromodulcitol (CAS 10318-26-0)1,2-Dibromoethane (CAS 106-93-4)Dibromomannitol (CAS 488-41-5)5,7-Dibromoquinoline (CAS 34522-69-5)1,3-Dibutyl-1-nitrosourea (CAS 56654-52-5)Dibutyltin diacetate (CAS 1067-33-0)3,5-Dichloro(N-1,1-dimethyl-2-propynyl)benzamide (CAS 23950-58-5) 2,3-Dichloro-p-dioxane (CAS 3883-43-0)1,1-Dichloro-1-fluoroethane (CAS 1717-00-6)α,β-Dichloro-β-formylacrylic acid (CAS 87-56-9)3,4′-Dichloro-2-methylacrylanilide (CAS 2164-09-2)2,3-Dichloro-1,4-naphthoquinone (CAS 117-80-6)2,6-Dichloro-4-nitroaniline (CAS 99-30-9)2,6-Dichloro-p-phenylenediamine (CAS 609-20-1)Dichloroacetic acid (CAS 79-43-6)Dichloroacetylene (CAS 7572-29-4)1,2-Dichlorobenzene (CAS 95-50-1)1,4-Dichlorobenzene (CAS 106-46-7)3,3′-Dichlorobenzidine (CAS 91-94-1)3,3′-Dichlorobenzidine.2HCl (CAS 612-83-9)1,4-Dichlorobutene-2 (65% trans-, 35% cis-) (CAS 764-41-0)trans-1,4-Dichlorobutene-2 (CAS 110-57-6)2,7-Dichlorodibenzo-p-dioxin (CAS 33857-26-0) Dichlorodifluoromethane (CAS 75-71-8)p,p′-Dichlorodiphenyl sulfone (CAS 80-07-9)1,1-Dichloroethane (CAS 75-34-3)1,2-Dichloroethane (CAS 107-06-2)2,4-Dichlorophenol (CAS 120-83-2)α-(2,4-Dichlorophenoxy)propionic acid (CAS 120-36-5)α-(2,5-Dichlorophenoxy)propionic acid (CAS 6965-71-5)2,4-Dichlorophenoxyacetic acid (CAS 94-75-7)2,4-Dichlorophenoxyacetic acid, n-butyl ester (CAS 94-80-4)2,4-Dichlorophenoxyacetic acid, isooctyl ester (CAS 25168-26-7)2,4-Dichlorophenoxyacetic acid, isopropyl ester (CAS 94-11-1)3-(3,4-Dichlorophenyl)-1,1-dimethylurea (CAS 330-54-1)2,4-Dichlorophenylbenzene sulfonate (CAS 97-16-5)1,2-Dichloropropane (CAS 78-87-5)Dichlorvos (CAS 62-73-7)Dichromate, sodium (CAS 10588-01-9)Dicofol (CAS 115-32-2)N,N′-Dicyclohexylthiourea (CAS 1212-29-9)Dicyclopentadiene dioxide (CAS 81-21-0)Dieldrin (CAS 60-57-1)Dieldrin, photo- (CAS 13366-73-9)d,l-Diepoxybutane (CAS 298-18-0)Diethyl-β,γ-epoxypropylphosphonate (CAS 7316-37-2)N,N-Diethyl-4-(4′-[pyridyl-1′-oxide]azo)aniline (CAS 7347-49-1)N,N-Diethyl-m-toluamide (CAS 134-62-3)O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothioate (CAS 2921-88-2)Diethylacetamide (CAS 685-91-6)Diethylacetylurea(±)-4-Diethylamino-1, 1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-phenylacetate.HCl monohydrateDiethylene glycol (CAS 111-46-6)Diethylformamide (CAS 617-84-5)Diethylmaleate (CAS 141-05-9)Diethylstilbestrol (CAS 56-53-1)N,N′-Diethylthiourea (CAS 105-55-5)2-(Difluoromethyl)-dl-ornithine (CAS 70052-12-9)1,2-Diformylhydrazine (CAS 628-36-4)Diftalone (CAS 21626-89-1)Diglycidyl resorcinol ether, technical grade (CAS 101-90-6)5,6-Dihydro-5-azacytidine (CAS 62488-57-7)1,2-Dihydro-2-(5-nitro-2-thienyl)quinazolin-4(3H)-one (CAS 33389-33-2) 3,6-Dihydro-2-nitroso-2H-1,2-oxazine (CAS 3276-41-3)3,4-Dihydrocoumarin (CAS 119-84-6)Dihydrosafrole (CAS 94-58-6)3,3′-Dihydroxybenzidine.2HCl (CAS 1592-36-5)24R,25-Dihydroxyvitamin D3 (CAS 55721-11-4)Diisononyl phthalate (CAS 68515-48-0)(R,R)-Dilevalol.HCl (CAS 75659-08-4)Dimethadione (CAS 695-53-4)Dimethoate (CAS 60-51-5)Dimethoxane (CAS 828-00-2)Dimethoxane, commercial grade (CAS 828-00-2)2,5-Dimethoxy-4′-aminostilbene (CAS 5803-51-0)2,4-Dimethoxyaniline.HCl (CAS 54150-69-5)3,3′-Dimethoxybenzidine-4,4′-diisocyanate (CAS 91-93-0)3,3′-Dimethoxybenzidine.2HCl (CAS 20325-40-0)5,7-Dimethoxycyclopentene[c]coumarin (CAS 1146-71-0)5,7-Dimethoxycyclopentenone[2,3-c]coumarin (CAS 1150-37-4)5,7-Dimethoxycyclopentenone[3,2-c]coumarin (CAS 1150-42-1)5,6-Dimethoxysterigmatocystin (CAS 65176-75-2)O,O-Dimethyl S-2(acetylamino)ethyl dithiophosphate, technical grade (CAS 13265-60-6)N,N-Dimethyl-4-aminoazobenzene (CAS 60-11-7)N,N′-Dimethyl-N,N′-dinitrosophthalamide (CAS 3851-16-9)Dimethyl hydrogen phosphite (CAS 868-85-9)Dimethyl methylphosphonate (CAS 756-79-6)Dimethyl morpholinophosphoramidate (CAS 597-25-1)4,6-Dimethyl-2-(5-nitro-2-furyl)pyrimidine (CAS 59-35-8)1,2-Dimethyl-5-nitroimidazole (CAS 551-92-8)Dimethyl terephthalate (CAS 120-61-6)Dimethylacetamide (CAS 127-19-5)6-Dimethylamino-4,4-diphenyl-3-heptanol acetate.HCl (CAS 43033-72-3) 6-Dimethylamino-4,4-diphenyl-3-heptanone.HCl (CAS 1095-90-5)trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole (CAS 55738-54-0)4-Dimethylamino-3,5-xylenol (CAS 6120-10-1)4-Dimethylaminoantipyrine (CAS 58-15-1)2-Dimethylaminoethanol (CAS 108-01-0) Dimethylaminoethylnitrosoethylurea, nitrite salt (CAS 142713-78-8)2,6-Dimethylaniline (CAS 87-62-7)N,N-Dimethylaniline (CAS 121-69-7)Dimethylarsinic acid (CAS 75-60-5)5,5-Dimethylbarbituric acid (CAS 24448-94-0)7,12-Dimethylbenz(a)anthracene (CAS 57-97-6)3,3′-Dimethylbenzidine.2HCl (CAS 612-82-8)Dimethylcarbamyl chloride (CAS 79-44-7)Dimethyldithiocarbamic acid, dimethylamine (CAS 598-64-1)N,N-Dimethyldodecylamine-N-oxide (CAS 1643-20-5) Dimethylformamide (CAS 68-12-2)1,1-Dimethylhydrazine (CAS 57-14-7)1,2-Dimethylhydrazine.2HCl (CAS 306-37-6)2-(2,2-Dimethylhydrazino)-4-(5-nitro-2-furyl)thiazole (CAS 26049-69-4) Dimethylnitramine (CAS 4164-28-7)Dimethylthiourea (CAS 61805-96-7)Dimethylvinyl chloride (CAS 513-37-1)2,4-Dinitro-6-tert-buthylphenyl methanesulfonate (CAS 29110-68-7) Dinitro(1-methylheptyl)phenyl crotonate, commercial grade (78%) (CAS 6119-92-2)2,4-Dinitrophenol (CAS 51-28-5)2,4-Dinitrophenol, sodium (CAS 1011-73-0)1,4-Dinitroso-2,6-dimethylpiperazine (CAS 55380-34-2) Dinitrosocaffeidine (CAS 145438-97-7)Dinitrosohomopiperazine (CAS 55557-00-1)N,N-Dinitrosopentamethylenetetramine (CAS 101-25-7) Dinitrosopiperazine (CAS 140-79-4)2,6-Dinitrotoluene (CAS 606-20-2)2,4-Dinitrotoluene (containing 0.5% 2,6-dinitrotoluene) (CAS 121-14-2) 2,4-Dinitrotoluene (containing 1.0-1.5% 2,6-dinitrotoluene) (CAS 121-14-2)2,4-Dinitrotoluene, practical grade (CAS 121-14-2)Dinitrotoluene, technical grade (2,4 (77%)- and 2,6 (19%)-) (CAS 25321-14-6)1,4-Dioxane (CAS 123-91-1)Dioxathion (CAS 78-34-2)Dipentamethylenethiuram hexasulfide (CAS 971-15-3) Dipentylnitrosamine (CAS 13256-06-9)Diphenhydramine.HCl (CAS 147-24-0)Diphenyl-p-phenylenediamine (CAS 74-31-7)Diphenylacetonitrile (CAS 86-29-3)Diphenylcarbonate (CAS 102-09-0)5,5-Diphenylhydantoin (CAS 57-41-0)N,N-Dipropyl-4-(4′-[pyridyl-1′-oxide]azo)anilineDipropylene glycol (CAS 25265-71-8)Dipyrone (CAS 68-89-3)Disodium 5′-ribonucleotide (CAS 80702-47-2)2,5-Dithiobiurea (CAS 142-46-1)Dithiooxamide (CAS 79-40-3)3-O-Dodecylcarbomethylascorbic acidn-Dodecylguanidine acetate (CAS 2439-10-3)dl-Dopa (CAS 63-84-3)Dopamine.HCl (CAS 62-31-7)Doxefazepam (CAS 40762-15-0)Doxylamine succinate (CAS 562-10-7)α-Ecdysone (CAS 3604-87-3)Edifas A (CAS 9004-59-5)Edifas B (CAS 9004-32-4)EDTA, trisodium salt trihydrate (CAS 150-38-9)Efonidipine.HCl ethanolate (CAS 111011-76-8)Ellagic acid (CAS 476-66-4)Elmiron (CAS 37319-17-8)Emetine.2HCl (CAS 316-42-7)Emodin (CAS 518-82-1)Emulsifier YN (CAS 55965-13-4)Endosulfan (CAS 115-29-7)Endrin (CAS 72-20-8)Enflurane (CAS 13838-16-9)Enovid (CAS 8015-30-3)Enovid-E (CAS 8015-30-3)Ephedrine sulphate (CAS 134-72-5)Epichlorohydrin (CAS 106-89-8)(–)-Epigallocatechin gallate (85% (–)-epigallocatechin gallate, 10% (–)-epigallocatechin, 5% (–)-epicatechin gallate) (CAS 989-51-5)l-Epinephrine.HCl (CAS 55-31-2)1,2-Epoxybutane (CAS 106-88-7)Erythorbate, sodium (CAS 6381-77-7)Erythromycin stearate (CAS 643-22-1)Estazolam (CAS 29975-16-4)Estradiol (CAS 50-28-2)Estradiol mustard (CAS 22966-79-6)Estragole (CAS 140-67-0)Ethinyl estradiol (CAS 57-63-6)Ethionamide (CAS 536-33-4)Ethionine (CAS 13073-35-3)dl-Ethionine (CAS 67-21-0)4-Ethoxy-phenylurea (CAS 150-69-6)o-Ethoxybenzamide (CAS 938-73-8)Ethoxyquin (CAS 91-53-2)Ethyl acrylate (CAS 140-88-5)Ethyl alcohol (CAS 64-17-5)Z-Ethyl-O,N,N-azoxyethane (CAS 16301-26-1)Z-Ethyl-O,N,N-azoxymethane (CAS 57497-29-7)Ethyl bromoacetate (CAS 105-36-2)S-Ethyl-l-cysteine (CAS 2629-59-6)p,p′-Ethyl-DDD (CAS 72-56-0)N-Ethyl-N-formylhydrazine (CAS 74920-78-8)Ethyl methylphenylglycidate (CAS 77-83-8)N-Ethyl-N′-nitro-N-nitrosoguanidine (CAS 63885-23-4)1-Ethyl-1-nitrosourea (CAS 759-73-9)Ethyl tellurac (CAS 20941-65-5)3-O-Ethylascorbic acid (CAS 86404-04-8)Ethylbenzene (CAS 100-41-4)Ethylene glycol (CAS 107-21-1)Ethylene glycol, cyclic sulfate (CAS 1072-53-3)Ethylene imine (CAS 151-56-4)Ethylene oxide (CAS 75-21-8)Ethylene thiourea (CAS 96-45-7)Ethylene urea (CAS 120-93-4)Ethylenebisdithiocarbamate, disodium (CAS 142-59-6)1-Ethyleneoxy-3,4-epoxycyclohexane (CAS 106-87-6)2-Ethylhexanol (CAS 104-76-7)di(2-Ethylhexyl)adipate (CAS 103-23-1)di(2-Ethylhexyl)phthalate (CAS 117-81-7)Ethylhydrazine.HCl (CAS 18413-14-4)1-Ethylnitroso-3-(2-hydroxyethyl)-urea (CAS 96724-44-6)1-Ethylnitroso-3-(2-oxopropyl)-urea (CAS 110559-84-7) Ethylnitrosocyanamide (CAS 38434-77-4)Ethylphenylacetylurea (CAS 90-49-3)4-Ethylsulphonylnaphthalene-1-sulfonamide (CAS 842-00-2) Ethynodiol diacetate (CAS 297-76-7)Etodolac (CAS 41340-25-4)Eucalyptol (CAS 470-82-6)Eugenol (CAS 97-53-0)Fadrozole.HCl (CAS 102676-31-3)Fenaminosulf, formulated (CAS 140-56-7)Fenthion (CAS 55-38-9)Fenvalerate (CAS 51630-58-1)Ferric chloride (CAS 7705-08-0)Ferric citrate tetrahydrate (CAS 2338-05-8)Ferric dimethyldithiocarbamate (CAS 14484-64-1)Finasteride (CAS 98319-26-7)Flecainide acetate (CAS 54143-56-5)Fluconazole (CAS 86386-73-4)Fluometuron (CAS 2164-17-2)N-(2-Fluorenyl)-2,2,2-trifluoroacetamide (CAS 363-17-7)Fluoride, sodium (CAS 7681-49-4)4′-Fluoro-4-aminodiphenyl (CAS 324-93-6)N-4-(4′-Fluorobiphenyl)acetamide (CAS 398-32-3)2-Fluoroethyl-nitrosourea (CAS 69112-98-7)5-Fluorouracil (CAS 51-21-8)Fluoxetine.HCl (CAS 59333-67-4)Fluvastatin (CAS 93957-54-1)Formaldehyde (CAS 50-00-0)Formic acid 2-[4-(2-furyl)-2-thiazolyl]hydrazide (CAS 31873-81-1) Formic acid 2-(4-methyl-2-thiazolyl)hydrazide (CAS 32852-21-4) Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide (CAS 3570-75-0) 1-Formyl-3-thiosemicarbazide (CAS 2302-84-3)Formylhydrazine (CAS 624-84-0)Fosetyl Al (CAS 39148-24-8)Fumonisin B1 (CAS 116355-83-0)2-Furaldehyde semicarbazone (CAS 2411-74-7)Furan (CAS 110-00-9)Furfural (CAS 98-01-1)。