MLN4924_905579-51-3_MSDS_MedChemExpress
Gelucire-14-44-SDS-MedChemExpress

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Nov.-23-2018Print Date:Nov.-23-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Gelucire 14/44Catalog No. :HY-Y1892CAS No. :121548-04-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:N/AMolecular Weight:N/ACAS No. :121548-04-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Pure form-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Oil)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
分子体积排阻高效液相色谱法测定低浓度重组人源化抗BCMA/CD3双特异性抗体药物的浓度

药物分析杂志Journal of Pharmaceutical Analysis药物分析杂志 线性关系考察 精密吸取混合对照品储备液、4、6、8、10 mL ,分别置10 mL 量瓶中,用70%甲醇水溶液定容至刻度,即得系列混合对照品溶液。
分别精密吸取上述系列混合对照品溶液10 μL ,按“2.1”项下色谱条件进样分析,测定峰面积。
以峰面积(Y )葛根素(puerarin ) 2. 连翘酯苷A (forsythiaside A ) 3. 黄芩苷(baicalin 牛蒡苷(arctiin )混合对照品(mixed reference substances ) B. 样品(sample ) C. 缺葛根阴性样品(negative sample of Puerariae Lobatae Radix ) D. 缺连翘阴性样negative sample of Forsythiae Fructus ) E. 缺黄芩阴性样品(negative sample of Scutellariae Radix ) F. 缺炒牛蒡子阴性样品(negative sample ofArctii Fructus ) 小儿解表颗粒HPLC 色谱图 HPLC chromatograms of Xiao ’er Jiebiao granules表2 4个成分的线性回归方程、相关系数(r )及线性范围Tab. 2 The regression equation ,correlation coefficients and linear ranges of 4 components成分(component )回归方程(regression equation )r线性范围(linear range )/(μg ·mL -1)葛根素(puerarin )Y =45.19X +7.5460.999 9 4.799~47.99连翘酯苷A forsythiaside A )Y =16.61X +1.3590.999 93.968~39.68黄芩苷(baicalin )Y =32.55X +13.430.999 916.76~167.6牛蒡苷(arctiin )Y =5.843X +0.992 80.999 97.082~70.82药物分析杂志药物分析杂志药物分析杂志药物分析杂志。
抗体公司

赛信通(上海)生物试剂有限公司
上海市浦东南路1101号远东大厦514室,200120 info@cst www.cst 2158356288 公司总部: 美国
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privatelyowned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activationstate and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine. 总引用数为4670,来自于1966篇文章。最常引用的试剂包括: Akt, ERK2, ERK1, p38, Akt1。
AbD Serotec (BioRad)
危险化学品特性表_第6类有毒品

目录表- 氰化钠的理化性质及危险特性................ 错误!未定义书签。
表- 氰化钾的理化性质及危险特性................ 错误!未定义书签。
表- 氰化铜的理化性质及危险特性................ 错误!未定义书签。
表- 氰化银的理化性质及危险特性................ 错误!未定义书签。
表- 氰化锌的理化性质及危险特性................ 错误!未定义书签。
表- 氰化金钾的理化性质及危险特性.............. 错误!未定义书签。
表- 三氧化(二)砷的理化性质及危险特性........ 错误!未定义书签。
表- 碳酸钡的理化性质及危险特性................ 错误!未定义书签。
表- 氯化钡的理化性质及危险特性表.............. 错误!未定义书签。
表- 氢氧化钡的理化性质及危险特性表............ 错误!未定义书签。
表- 环氧氯丙烷的理化性质和危险特性表.......... 错误!未定义书签。
表- 硝基苯的理化性质和危险特性表.............. 错误!未定义书签。
表- 氯化苄的理化性质和危险特性表.............. 错误!未定义书签。
表- 二氯化苄的理化性质及危险特性.............. 错误!未定义书签。
表- 苯酚的理化性质及危险特性表................ 错误!未定义书签。
表- 邻甲(苯)酚的理化性质及危险特性.......... 错误!未定义书签。
表- N,N-二甲(基)苯胺的理化性质和危险特性表.... 错误!未定义书签。
表- 甲苯-2,4-二异氰酸酯的理化性质及危险特性表错误!未定义书签。
表- 六亚甲基二异氰酸酯的理化性质及危险特性.... 错误!未定义书签。
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表- 灭害威的理化性质及危险特性表.............. 错误!未定义书签。
UHPLC-MS

UHPLC-MS/MS法测定瑞戈非尼中两种痕量基因毒性杂质陈爽ꎬ刘柱ꎬ石云峰ꎬ朱价ꎬ罗英(浙江省食品药品检验研究院ꎬ浙江杭州310058)摘要:目的㊀建立超高效液相色谱-串联质谱(UHPLC-MS/MS)方法测定瑞戈非尼中两类基因毒性杂质[3-氟-4-氨基苯酚(SM2)㊁3-三氟甲基-4-氯异氰酸苯酯(SM3)]的含量ꎮ方法㊀采用色谱柱AgilentRRHDC18(2.1mmˑ100mmꎬ1.8μm)ꎬ流动相为0.05%甲酸水-甲醇ꎬ梯度洗脱ꎬ流速为0.3mL min-1ꎬ柱温为35ħꎻ采用Agilent1290-6470A液质联用仪和电喷雾离子源(AJSESI)源检测ꎬ正负离子模式采集数据ꎮ结果㊀本方法的专属性㊁线性与范围㊁定量限与检测限㊁准确度㊁精密度及稳定性均符合«中国药典»的验证指标ꎮ结论㊀本方法操作简便ꎬ结果可靠ꎬ用于两批瑞戈非尼中潜在毒性杂质(3-氟-4-氨基苯酚㊁3-三氟甲基-4-氯异氰酸苯酯)的测定ꎮ两批样品中均未检测到SM2ꎬ而基因毒性杂质SM3的含量分别为13.6ˑ10-6和41.4ˑ10-6ꎮ关键词:瑞戈非尼ꎻ基因毒性杂质ꎻ超高效液相色谱-串联质谱中图分类号:R927.1㊀文献标志码:A㊀文章编号:2095-5375(2023)07-0485-005doi:10.13506/j.cnki.jpr.2023.07.010DeterminationoftwotracegenotoxicimpuritiesinRegorafenibbyUHPLC-MS/MSCHENShuangꎬLIUZhuꎬSHIYunfengꎬZHUJiaꎬLUOYing(ZhejiangInstituteforFoodandDrugControlꎬHangzhou310058ꎬChina)Abstract:Objective㊀ToestablishanUHPLC-MS/MSanalyticalmethodforthedeterminationofgenotoxicimpuritiesinRegorafenib.Methods㊀ThemethodwasachievedonaAgilentRRHDC18column(2.1mmˑ100mmꎬ1.8μm)utilizingamobilephaseof0.05%Formicacidwater(A)-Methanol(B)withgradientelutionattheflowrateof0.3mL min-1.Thetemperatureofcolumnwassetat35ħ.TheAgilent1290-6470ALC-MSwasusedtodetect(AJSESIsourceꎬinMultipleReactionMonitoringmode).Results㊀ThespecificityꎬlinearityandrangeꎬLOQandLODꎬaccuracyꎬprecisionandstabilityofthemethodwereallinaccordancewiththevalidationofChinesePharmacopoeia.Conclusion㊀Theproposedmethodwassuccessfullyappliedtodeterminethetrace-levelPGIsintwobatchesofregorafenib.ThecontentsofSM2werenotobservedinthetwobatchesofsamplesꎬwhereasthecontentsofSM3weredeterminedtobe13.6ˑ10-6and41.4ˑ10-6ꎬrespectively.Keywords:RegorafenibꎻGenotoxicimpurityꎻUHPLC-MS/MS㊀㊀基因毒性杂质(或遗传毒性杂质ꎬgenotoxicim ̄purityꎬGTI)是少量即能引起细胞DNA损伤ꎬ诱导基因突变ꎬ并具有致癌倾向的化合物[1]ꎮ欧洲药品管理局(EMEA)㊁美国食品药品管理局(FDA)及人用药品注册技术要求国际协调会(ICH)先后颁布了基因毒性杂质控制的指导文件[2-4]ꎬ推荐以毒理学关注阈值(TTCꎬ1.5μg d-1)来控制用药风险ꎬ并发布基因毒性警示结构基团ꎮ瑞戈非尼(Regorafenib)是拜耳药业研发并于2017年3月在国内上市的一种新型口服多靶点的磷酸激酶抑制剂ꎬ本品以促进肿瘤血管生成和细胞增殖的多种蛋白激酶为靶标ꎬ达到治疗晚期及转移性结肠癌㊁进展期肝细胞癌㊁胃肠道恶性间质肿瘤㊁儿童神经母细胞瘤和胶质母细胞瘤及一些转移性实体肿瘤的目的ꎮ瑞戈非尼的合成路线中起始物料SM2㊁SM3结构中均含有苯胺类基因毒性警示结构基团ꎬ具有潜在基因毒性ꎬ详见图1ꎮ瑞戈非尼已收载于«中国药典»和«欧洲药典»ꎬ已经报道了一种LC-MS/MS法定量同时测定肝细胞癌患者血浆中瑞戈非尼中及其两种活性代谢物的含量的方法[17]ꎬ但目前也未见相关文献报道本品中两种苯胺类基因毒性杂质SM2㊁SM3的测定方法ꎮ㊀作者简介:陈爽ꎬ女ꎬ硕士ꎬ副主任药师ꎬ研究方向:药物质量研究㊁标准提高研究ꎬE-mail:credear@126.comA.3-氟-4-氨基苯酚(SM2)ꎻB.3-三氟甲基-4-氯异氰酸苯酯(SM3)图1㊀瑞戈非尼中苯胺类基因毒性杂质结构因此建立超高效液相色谱-串联质谱(UHPLC-MS/MS)方法对瑞戈非尼中少量的苯胺类基因毒性杂质的含量进行控制ꎮ本研究依照ICH推荐的条件ꎬ建立了方法并从方法的专属性㊁溶液稳定性㊁线性与范围㊁定量限与检测限㊁准确度㊁精密度方面进行了方法学研究ꎬ本法灵敏㊁可靠㊁简便ꎬ为瑞戈非尼工艺过程控制和质量保障提供参考依据ꎮ1㊀仪器与试剂Agilent1290-6470ALC-MS联用系统(美国安捷伦)ꎬ配备电喷雾离子源(AJSESI)ꎬ质谱软件为AgilentMassHunter工作站ꎻXS205DU百万分之一电子天平(瑞士梅特勒托利多公司)ꎮAgilentRRHDC18(2.1mmˑ100mmꎬ1.8μmꎬ填料:十八烷基硅烷键合硅胶ꎻAgilent公司)ꎮ3-氟-4-氨基苯酚对照品(批号:P1156811ꎬ纯度:98%)ꎬ3-三氟甲基-4-氯异氰酸苯酯对照品(杭州华东医药集团新药研究院有限公司ꎬ批号:191201ꎬ纯度:99.76%)ꎻ瑞戈非尼(批号:RGFN-B-190901㊁Z193-A1911001ꎬ由A公司提供)ꎻ甲醇(默克试剂有限公司)㊁异丙醇㊁甲酸(阿拉丁有限公司)均为色谱级ꎮ2㊀方法与结果2.1㊀色谱条件㊀液相色谱柱:AgilentRRHDC18(2.1mmˑ100mmꎬ1.8μm)ꎻ流速0.3mL min-1ꎻ0.05%甲酸水为流动相Aꎬ甲醇为流动相Bꎬ梯度洗脱(0~1.2minꎬ10%Bꎻ1.2~4.0minꎬ10%Bң60%Bꎻ4.0~8.0minꎬ60%Bꎻ8.0~13.0minꎬ95%Bꎻ13.0~13.10minꎬ95%Bң10%Bꎻ13.10~15.0minꎬ10%B)ꎻ柱温35ħꎻ进样体积5μLꎮ取0.6ng mL-1混标对照品溶液ꎬ在MRM模式下进样分析ꎬ结果如图2所示ꎬ各杂质之间分离度良好ꎮ2.2㊀质谱条件㊀采用电喷雾离子源(AJSESI)ꎬ正负离子检测模式MRM采集(SM2正离子模式㊁SM3㊀SM2[3-氟-4-氨基苯酚(3-Fluoro-4-aminophenol)]ꎻSM3[3-三氟甲基-4-氯异氰酸苯酯(3-trifluoromethyl-4-phenyl ̄chloroisocyanate)]图2㊀混合对照品溶液总离子流图负离子模式)ꎬ参数见表1ꎮ喷雾电压为3.5kVꎬ鞘气为250ħꎬ鞘气流速为11L min-1ꎬ雾化气为45psiꎬ干燥气温度为300ħꎬ干燥气流速为5L min-1ꎮ母离子及子离子:取0.6μg mL-1混标对照品溶液ꎬ在Scan模式下进样ꎬ进行MS分析ꎬ两种基因毒性杂质的质谱图如图4所示ꎬ其中3-氟-4-氨基苯酚的母离子为m/z128.05ꎬ3-三氟甲基-4-氯异氰酸苯酯的母离子为m/z280.00ꎮ各基因毒性杂质的MRM参数见表1ꎬ定量离子及定性离子的选择见表1ꎮ表1㊀MRM采集参数设置化合物类型母离子(m/z)子离子(m/z)碰撞能量/eV碎裂电压/V扫描时间/msSM2(ESI+)SM3(ESI-)定量离子128.0510817定性离子128.0581.125定量离子280219.913定性离子280199.92585112100㊀SM2[3-氟-4-氨基苯酚(3-fluoro-4-aminophenol)]ꎻSM3[3-三氟甲基-4-氯异氰酸苯酯(3-trifluoromethyl-4-phenyl ̄chloroisocyanate)]图3㊀两种基因毒性杂质的质谱图2.3㊀混标对照品溶液㊀精密称取3-氟-4-氨基苯酚对照品㊁3-三氟甲基-4-氯异氰酸苯酯对照品各约6mgꎬ加稀释剂异丙醇溶解并稀释成6ng mL-1的混标对照品储备液ꎮ精密量取适量ꎬ稀释10倍ꎬ作为0.6ng mL-1混标对照品溶液ꎮ2.4㊀供试品溶液㊀取本品约20mgꎬ精密称定ꎬ置20mL容量瓶ꎬ用稀释剂溶解并稀释到刻度ꎬ摇匀ꎻ再精密量取0.1mLꎬ置10mL容量瓶ꎮ异丙醇稀释至刻度ꎬ摇匀ꎬ作为供试品溶液(10μg mL-1)ꎮ2.5㊀100%加标供试品溶液㊀取本品约20mgꎬ精密称定ꎬ置20mL量瓶中ꎬ用异丙醇溶解稀释至刻度ꎬ摇匀ꎻ再精密量取0.1mLꎬ置10mL容量瓶ꎬ加入1mL对照品储备液后ꎬ再用异丙醇稀释至刻度ꎬ摇匀ꎬ作为100%加标供试品溶液ꎮ2.6㊀方法学考察㊀2.6.1㊀专属性试验㊀取稀释剂照上述条件进行试验ꎬ记录色谱图ꎬ结果显示稀释剂不干扰测定ꎬ表明该方法专属性良好ꎮ2.6.2㊀线性关系㊁检测限和定量限㊀精密量取混标对照品储备液适量ꎬ加稀释剂稀释得到浓度分别为0.15㊁0.3㊁0.45㊁0.6㊁0.9㊁1.2ng mL-1的混标对照品溶液ꎬ进样分析ꎬ绘制标准曲线ꎬ得线性方程(见表2)ꎮ逐步稀释ꎬ考察定量限及检测限(见图4)ꎮ表2㊀瑞戈非尼中两种基因毒性杂质的线性范围㊁定量检测限及精密度参数SM2SM3线性方程Y=4799.5X+27.1Y=893.3X+27.1范围/ng mL-10.15~1.170.15~1.19r0.99990.9991检测限/ng mL-10.060.06定量限/ng mL-10.150.15精密度RSD(%)1.321.97中间精密度RSD(%)2.532.24图4㊀定量限和检测限MRM质谱图2.6.3㊀稳定性试验㊀取 2.3 项下0.6ng mL-1的混标对照品溶液ꎬ 2.5 项下10μg mL-1的100%加标供试品溶液ꎬ连续进样16h进行分析ꎬ各峰面积偏离度的绝对值在8h内均小于17.22%ꎬ表明对照品溶液和100%加标供试品溶液在8h内稳定性良好ꎮ2.6.4㊀准确度和精密度试验㊀精密称取瑞戈非尼(批号:RGFN-B-190901㊁Z193-A1911001)约20mgꎬ一式12份ꎬ分别置20mL量瓶中ꎬ用异丙醇溶解稀释至刻度ꎬ摇匀ꎻ再精密量取0.1mLꎬ置10mL容量瓶ꎬ精密加入 2.3 项下浓度为6ng mL-1的混标对照品储备液溶液0.25㊁0.5㊁1.0㊁1.5mLꎬ分别溶解并稀释至刻度ꎬ摇匀ꎬ即得低(0.15ng mL-1ꎬ3份)㊁中(0.30ng mL-1ꎬ3份)㊁高(0.60ng mL-1ꎬ3份)㊁极高(0.90ng mL-1ꎬ3份)4个浓度的供试品加标溶液ꎬ取混标对照品溶液和各加标供试品溶液分别进样分析ꎬ外标法计算回收率结果见表3ꎬ各基因毒性杂质回收率均在90.64%~105.44%之间ꎬRSD均小于3.50%ꎬ表明各基因毒性杂质回收率和精密度良好ꎮ2.7㊀样品测定㊀取瑞戈非尼供试品2批(批号:RGFN-B-190901㊁Z193-A1911001)ꎬ每批精密称取2份约20mgꎬ置20mL量瓶中ꎬ加稀释剂溶解并稀释至刻度ꎬ摇匀ꎻ再精密量取0.1mLꎬ置10mL容量瓶ꎬ异丙醇稀释至刻度ꎬ摇匀ꎬ作为供试品溶液(10μg mL-1)ꎬ进样分析ꎬ结果2批次瑞戈非尼中SM2均未检出ꎬSM3均有检出(见表4)ꎮ表3㊀瑞戈非尼中各基因毒性杂质的回收率化合物加入量测得量回收率平均回收RSD(%)SM31.502.995.988.982.77101.332.78100.673.9790.644.1395.994.32102.347.0596.827.2299.677.42102.8410.25100.0010.0998.3310.2399.8999.153.41表4㊀瑞戈非尼中基因毒性杂质检测结果批号SM2含量(%)SM3含量(%)Z193-A19110010.00000.00136RGFN-B-1909010.00000.004143㊀讨论3.1㊀瑞戈非尼的合成工艺㊀如图1所示ꎬ以3-氟-4-氨基苯酚和N-甲基-4-氯-2-吡啶甲酰胺为原料㊁氢氧化钠为碱ꎬTHF为溶剂ꎬ回流反应得到中间体4-(4-氨基-3-氟苯氧基)-N-甲基吡啶-2-甲酰胺ꎬ该中间体再与4-氯-3-三氟甲基苯胺以羰基连接得到瑞戈非尼无水物(4-[4-[[[4-氯-3-(三氟甲基)苯基]氨基甲酰]氨基]-3-氟苯氧基]-N-甲基吡啶-2-甲酰胺)ꎬ加水而成ꎮ合成路线中涉及多个起始物料及中间体带有基因警示结构ꎬ因此ꎬ必须对瑞戈非尼合成路线中引入的带有基因警示结构的潜在基因毒性杂质进行控制ꎮ3.2㊀控制限度㊀参照瑞戈非尼片药品使用说明书ꎬ建议每日最低剂量为80mgꎬ每日最高剂量为160mgꎮ因为瑞戈非尼为抗肿瘤用药ꎬ可以不以ICHM7推荐的最严格的毒理学关注阈值(TTCꎬ1.5μg d-1)为控制限制ꎮ本研究基于治疗期ꎬ以相对严格的1~10年治疗期的TTC(10μg d-1)为控制限制计算ꎬ瑞戈非尼中基因毒性杂质限度应为62.5ˑ10-6ꎬ本研究以60ˑ10-6作为瑞戈非尼中基因毒性杂质的控制限度ꎮ本次研究用样品中未检出SM2ꎬ检出的SM3分别为13.6ˑ10-6㊁41.4ˑ10-6ꎬ均符合限度要求ꎬ但SM3检出量已超30%限度ꎬ值得关切ꎮ3.3㊀色谱条件的优化㊀色谱条件优化试验中ꎬ探索了甲醇㊁异丙醇和乙腈3种有机相(B相)ꎬ水相(A相)中添加不同比率的酸(0.1%甲酸水ꎬ0.05%甲酸水和0.1%乙酸水)对分离度和灵敏度的影响ꎮ结果显示ꎬ采用AgilentRRHDC18色谱柱ꎬ当流动相0.05%甲酸水溶液-甲醇梯度洗脱时ꎬ3-氟-4-氨基苯酚(SM2)㊁3-三氟甲基-4-氯异氰酸苯酯(SM3)响应较好ꎬ且两个化合物分离度良好ꎬ故流动相中选择0.05%甲酸水ꎮ本试验考察了流速0.2~0.4mL min-1范围内对苯胺类物质响应和峰形的影响ꎬ发现流速0.3mL 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二甲基吡啶

3,5-二甲基吡啶3,5-二甲基吡啶CAS号:591-22-0英文名称:3,5-Lutidine英文同义词:35L;3,5-LUTIDINE;3,5-DIMETHYLPYRIDINE;3,5-dimethyl-pyridin;pyridine,3,5-dimethyl-;Lutidine,98%;3 5-LUTIDINESTANDARD FOR GC;3,5-LUTIDINE, 98+%;3,5-DIMETHYLPYRIDINE98+%;3,5-Dimetylpyridine;3,5-Lutidine,99%;3,5-LUTIDINE 3,5-DIMETHYLPYRIDINE中文名称:3,5-二甲基吡啶中文同义词:3,5-二甲基吡啶;3,5-卢剔啶;3,5-二甲基氮杂苯;3,5-二甲基啶;3,5-二甲基吡啶,99%CBNumber:CB4412061分子式:C7H9N分子量:107.15MOLFile:591-22-0.mol3,5-二甲基吡啶化学性质熔点: -9 °C沸点: 169-170 °C(lit.)密度: 0.939 g/mL at 25 °C(lit.)蒸气压: 1.5 mm Hg ( 20 °C)折射率: n20/D 1.504(lit.)闪点: 128 °F储存条件: 2-8°C水溶解性: 33 g/L (20 ºC)BRN : 105682CAS 数据库: 591-22-0(CAS DataBase Reference) NIST化学物质信息: Pyridine, 3,5-dimethyl-(591-22-0) EPA化学物质信息: Pyridine, 3,5-dimethyl-(591-22-0)安全信息危险品标志: Xn,F,Xi危险类别码: 10-20/21/22-36/37/38-41安全说明: 16-26-36-36/37危险品运输编号: UN 1993 3/PG 3WGK Germany : 3F : 8Hazard Note : Irritant/FlammableHazardClass : 3PackingGroup : III海关编码: 293339993,5-二甲基吡啶 MSDS3,5-二甲基吡啶3,5-Dimethylpyridine3,5-二甲基吡啶性质、用途与生产工艺用途用作有机合成原料类别易燃液体可燃性危险特性遇明火、高温、强氧化剂可燃; 高温分解有毒氮氧化物气体储运特性包装完整、轻装轻卸; 库房通风、远离明火、高温、与氧化剂分开存放灭火剂泡沫、干粉、二氧化碳、砂土3,5-二甲基吡啶上下游产品信息上游原料下游产品3,5-二甲基-4-氨基吡啶3-氨基-5-甲基吡啶。
常见有机溶剂的介电常数

常见有机溶剂的介电常数介电常数Material 物质名* 温度(°C) 介电常数ABS RESIN, LUMP 丙烯晴-丁二烯-苯乙烯树脂块2.4-4.1 ABS RESIN, PELLET 丙烯晴-丁二烯-苯乙烯树脂球 1.5-2.5 ACENAPHTHENE 二氢苊21 3.0ACETAL 聚甲醛21 3.6ACETAL BROMIDE 溴代乙缩醛二乙醇16.5ACETAL DOXIME 乙二醛肟20 3.4ACETALDEHYDE 乙醛5 21.8ACETAMIDE 乙酰胺20 41ACETAMIDE 乙酰胺82 59ACETANILIDE 乙醛222.9ACETIC ACID 乙酸206.2ACETIC ACID 乙酸24.1ACETIC ANHYDRIDE乙酸酐1921.0ACETONE丙酮2520.7ACETONE丙酮5317.7ACETONE 丙酮0 1.0159ACETONITRILE 乙睛21 37.5ACETOPHENONE 苯乙酮24 17.3ACETOXIME 丙酮肟-4 3ACETYL ACETONE 乙酰丙酮20 23.1ACETYL BROMIDE 乙酰溴20 16.5ACETYL CHLORIDE 乙酰氯20 15.8ACETYLE ACETONE 乙酰丙酮20 25ACETYLENE 乙炔0 1.0217ACETYLMETHYL HEXYL KETONE 己基甲酮19 27.9 ACRYLIC RESIN 丙烯酸树脂2.7 - 4.5ACTEAL 乙醛21.0-3.6AIR 空气1AIR (DRY) 空气(干燥)20 1.000536ALCOHOL, INDUSTRIAL 工业酒精16-31ALKYD RESIN 醇酸树脂3.5-5ALL YL ALCOHOL 丙烯醇14 22ALL YL BROMIDE 溴丙烯19 7.0ALL YL CHLORIDE 烯丙基氯20 8.2ALL YL IODIDE 碘丙烯19 6.1ALL YL ISOTHIOCYANATE 异硫氰酸丙烯酯18 17.2ALL YL RESIN (CAST) 烯丙基脂(CAST)3.6 - 4.5 ALUMINA 氧化铝9.3-11.5ALUMINA 氧化铝4.5ALUMINA CHINA 氧化铝瓷3.1-3.9ALUMINUM BROMIDE 溴化铝100 3.4ALUMINUM FLUORIDE 氟化铝2.2ALUMINUM HYDROXIDE 氢氧化铝2.2ALUMINUM OLEATE 油酸铝20 2.4ALUMINUM PHOSPHATE 硷式磷酸铝-14ALUMINUM POWDER 铝粉1.6-1.8AMBER 琥珀2.8-2.9AMINOALKYD RESIN 酸硬化树脂3.9-4.2AMMONIA 血氨-59 25DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表AMMONIA 血氨-34 22AMMONIA 血氨4 18.9AMMONIA 血氨21 16.5AMMONIA (GAS? ) 血氨(气体)0 72AMMONIUM BROMIDE 溴化铵7.2AMMONIUM CHLORIDE 氯化铵7AMYL ACETATE 醋酸戊酯20 5AMYL ALCOHOL 戊醇-118 35.5AMYL ALCOHOL 戊醇20 15.8AMYL ALCOHOL 戊醇60 11.2AMYL BENZOATE 苯甲酸戊酯20 5.1AMYL BROMIDE 溴化环戊烷10 6.3AMYL CHLORIDE 戊基氯11 6.6AMYL ETHER 戊基醚16 3.1AMYL FORMA TE 甲酸戊基19 5.7AMYL IODIDE 碘化戊基17 6.9AMYL NITRATE硝酸戊基179.1AMYL THIOCYANATE 硫氰酸盐戊基20 17.4AMYLAMINE 戊胺22 4.6AMYLENE 戊烯21 2AMYLENE BROMIDE 溴戊烯14 5.6 AMYLENETETRARARBOXYLATE 19 4.4 AMYLMERCAPTAN 戊基硫醇20 4.7ANILINE 苯胺0 7.8ANILINE 苯胺20 7.3ANILINE 苯胺100 5.5ANILINE FORMALDEHYDE RESIN 苯氨-甲醛树脂3.5 - 3.6 ANILINE RESIN 苯胺树脂3.4-3.8ANISALDEHYDE 茴香醛20 15.8ANISALDOXINE 茴香肟63 9.2ANISOLE 苯甲醚20 4.3ANITMONY TRICHLORIDE 三氯化锑5.3ANTIMONY PENTACHLORIDE 五氯化锑20 3.2ANTIMONY TRIBROMIDE 三溴化锑100 20.9ANTIMONY TRICHLORIDE 三氯化锑5.3ANTIMONY TRICHLORIDE 三溴化锑74 33ANTIMONY TRICODIDE 三碘化锑175 13.9APATITE 磷灰石7.4ARGON 氩-227 1.5ARGON 氩20 1.000513ARSENIC TRIBROMIDE 三溴化砷37 9ARSENIC TRICHLORIDE 三氯化砷66 7ARSENIC TRICHLORIDE 三氯化砷21 12.4ARSENIC TRIIODIDE 三碘化砷150 7ARSINE 胂-100 2.5ASBESTOS 石棉3.0 - 4.8ASH (FL Y ) 飘尘1.7 - 2.0ASPHALT 沥青24 2.6ASPHALT, LIQUID 沥青,液体2.5-3.2Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表AZOXYANISOLE 氧化偶氮茴香醚50 2.3 AZOXYBENZENE 偶氮苯40 5.1AZOXYPHENITOLE 氧化偶氮150 6.8BAKELITE 酚醛塑料3.5-5.0BALLAST 碎石5.4-5.6BALLMILL FEED (CEMENT ) 球磨给料(水泥)4.5 BALM, REFUSE 选票,拒绝3.1BARIUM CHLORIDE 氯化钡9.4BARIUM CHLORIDE (2H20 ) 氯化钡(2H20 )9.4BARIUM CHLORIDE (ANHYD) 氯化钡(酐)11BARIUM NITRATE 硝酸钡5.8BARIUM SULFATE 硫酸钡16 11.4BARLEY FLOUR 大麦粉3.0 - 4.0BARLEY POWDER 大麦粉3.0-4.0BEESW AX 蜂蜡2.7 - 3.0BENZAL CHLORIDE 二氯化苄20 6.9BENZALDEHYDE 苯甲醛20 17.8BENZALDOXIME 苯甲醛肟20 3.8BENZENE 苯20 2.3BENZENE 苯135 2.1BENZENE 苯371 1.0028BENZIL 苯偶酰94 13BENZONITRILE 苯甲腈20 26BENZOPHENONE 二苯甲酮50 11.4BENZOPHENONE 二苯甲酮20 13BENZOTRICHLORIDE 三氯甲苯20 7.4BENZOYL CHLORIDE 苯甲酰氯21 22.1BENZOYL CHLORIDE 苯甲酰氯0 23 BENZOYLACETONE 苯甲酰丙酮20 29BENZYL ACETATE 乙酸苯甲酯21 5BENZYL ALCOHOL 笨甲醇20 13BENZYL BENZOA TE 苯甲酸苄酯20 4.8BENZYL CHLORIDE 苯甲氯20 6.4BENZYL CYANIDE 苯乙腈20 18.3BENZYL CYANIDE 苯乙腈68 6BENZYL SALICYLATE 水杨酸苄酯20 4.1BENZYLAMINE 苄胺20 4.6BENZYLETHYLAMINE 苄基乙基胺20 4.3 BENZYLMETHYLAMINE 甲基苄胺19 4.4BERYL 绿云石6BIPHENYL 联苯20BIWAX 2.5BLEACHING POWDER 漂白粉4.5BONE BLACK 骨炭5.0-6.0BORNYL ACETATE 乙酸龙脑酯21 4.6BORON BROMIDE 溴化硼0 2.6BORONYL CHLORIDE 氯化硼94 5.2BROMACEYTAL BROMIDE 溴代酰溴-11Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表BROMAL 三溴乙醛21 7.6BROMINE 溴20 3.1BROMINE 溴0 1.0128BROMO-2-ETHOXYPENTANE 溴-2-乙氧基戊烷24 6.5 BROMOACETYL BROMIDE 溴乙酰溴20 12.6 BROMOANILINE 溴苯胺20 13BROMOANISOLE 溴苯甲醚30 7.1BROMOBENZENE 溴苯20 5.4BROMOBUTYLENE 丁撑溴20 5.8BROMOBUTYRIC ACID 溴丁酸20 7.2 BROMOCTADECANE 溴代十八烷3.53BROMODECANE 溴代癸烷24 4.4BROMODEODECANE 溴代十二烷24 4.1 BROMODOCOSANE 溴代二十二烷54 3.1 BROMODOECANE 溴代DOECANE 24 4.07 BROMOFORM 三溴甲烷20 4.4BROMOHEPTANE 溴代庚烷24 5.3 BROMOHEXADECANE 溴代十六烷24 3.7 BROMOHEXANE 溴己烷24 5.8BROMOISOV ALERIC ACID 溴代异戊酸20 6.5 BROMOMETHANE 溴甲烷0 9.8BROMONAPTHALENE 溴代萘烯19 5.1 BROMOOCTADECANE 溴代正辛烷30 3.5 BROMOPENTADECANE 溴代十五烷20 3.9 BROMOPHROPIONIC ACID 溴代丙酸20 11 BROMOTOLUENE 溴甲苯20 5.1BROMOTRIDECANE 溴代十三烷10 4.2 BROMOUNDECANE 溴代十一烷-9 4.7BRONYL CHLORIDE 氯化乙酸34 5.21BUTANE 丁烷-1 1.4BUTANOL (1) 丁醇(1)20 17.8BUTANONE 丁酮20 18.5BUTYCIC ANHYDRIDE 丁酸酐-7 12BUTYL CHLORAL 丁基氯醛18 10BUTYL CHLORIDE 氯化橡胶20 9.6BUTYL OLEATE 油酸丁酯25 4BUTYL STEARATE 硬脂酸丁酯27 3.1BUTYLACETATE 丁酸乙酯19 5.1BUTYLAMINE 丁胺21 5.4BUTYRALDEHYDE 丁醛26 13.4BUTYRIC ACID 丁酸20 3BUTYRIC ANHYDRIDE 丁酸酐20 12BUTYRONITRILE 丁腈21 20.7CABLE OIL 电缆油27 2.2CABONDIOXIDE 二氧化碳20 1.000921CALCIM FLUORIDE 氟化钙7.4CALCITE 白云石8CALCIUM 钙3Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表CALCIUM CARBONA TE 碳酸钙6.1-9.1CALCIUM FLUORIDE 氟化钙7.4CALCIUM OXIDE, GRANULE 氧化钙,颗粒11.8CALCIUM SULFATE 硫酸钙5.6CALCIUM SULFATE (H2O 硫酸钙(H2O)5.6CALCIUM SUPERPHOSPHA TE 过磷酸钙14-15CAMPHANEDIONE 莰烷二酮203 16CAMPHENE 莰烯20 2.7CAMPHENE 莰烯40 2.3CAMPHER, CRYSTAL 樟脑,结晶10/11CAMPHORIC IMIDE 4 樟脑酰亚胺 4 27 5.5 CAMPHORPINACONE 樟脑频哪醇20 3.6CAPRILIC ACID 辛酸-8 3.2CAPROIC ACID 己酸71 2.6CAPROLACTAM MONOMER 己内酰胺单体1.7 - 1.9CAPRYLIC ACID 辛酸18 3.2CARBIDE 碳5.8 - 7.0CARBIDE, POWDER 碳,粉末5.8-7.0CARBON BLACK 碳黑2.5 - 3.0CARBON DIOXIDE 二氧化碳0 1.6CARBON DIOXIDE, LIQUID 二氧化碳,液体1.6CARBON DISULFIDE, LIQUID 二硫化碳,液体2.6CARBON DISULPHIDE 二硫化碳20 2.6CARBON DISULPHIDE 二硫化碳82 2.2CARBON TETRACHLORIDE 四氯化碳20 2.2CARNAUBA WAX 巴西棕榈蜡2.9CARVENONE 香芹烯酮20 18.4CARVOL 香草醇18 11.2CARVONE 香芹酮22 11CASEIN 酪蛋白6.1 - 6.8CASEIN RESIN 酪蛋白脂6.7CASSITERITE 锡石23.4CASTOR OIL 蓖麻油16 4.7CASTOR OIL 蓖麻油27 2.6CASTOR OIL (HYDROGENA TED ) 蓖麻油(氢化)27 10.3 CEDRENE 雪松烯24 3.2CELLOPHANE 赛璐玢3.2-6.4CELLULOID 赛璐珞3.3-11CELLULOSE 纤维素3.2-7.5CELLULOSE ACETA TE 乙酸纤维素3.2-7CELLULOSE ACETA TE (MOLDING ) 乙酸纤维素(成型)3.2 - 7.0 CELLULOSE ACETA TE (SHEET ) 乙酸纤维素(单独)4.0 - 5.5 CELLULOSE ACETA TE BUTYRA TE 乙酸丁酸纤维素3.2 - 6.2 CELLULOSE NITRATE (PROXYLIN ) 硝酸纤维素6.4CEMENT 水泥1.5 - 2.1CEMENT (PLAIN ) 水泥(平面)1.5 - 2.1CEMENT, PORTLAND 水泥,波特兰2.5-2.6CEMENT, POWDER 水泥,粉末5/10CEREALS (DRY ) 谷类(干燥)3.0 - 5.0Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表CERESE W AX 地蜡2.4CESIUM IODINE 碘化铯5.6CETYL IODIDE 鲸蜡基碘20 3.3CHARCOAL 木炭1.2-1.81CHINAW ARE, HARD 瓷器,(硬的)4/7CHLORACETIC ACID 氢碳酸60 12.3CHLORACETONE 氯丙酮29.8CHLORAL 三氯乙醛20 4.9CHLORHEXANONE OXIME 氯己酮肟3CHLORINE 氯-46 2.1CHLORINE 氯0 2CHLORINE 氯61 1.5CHLORINE, LIQUID 氯,液体2CHLOROACETIC ACID 氯乙酸20 21CHLOROACETONE 氯丙酮20 29.8CHLOROBENZENE 氯苯25 5.6CHLOROBENZENE 氯苯38 4.7CHLOROBENZENE 氯苯110 4.1CHLOROBENZINE, LIQUID 氯苯,液体 5.5-6.3 CHLOROCYCLOHEXANE 氯代环己烷24 7.6 CHLOROFORM 三氯甲烷0 5.5CHLOROFORM 三氯甲烷20 4.8CHLOROFORM 三氯甲烷100 3.7CHLOROHEPTANE 氯庚烷22 5.5CHLOROHEXANONE OXIME 氯己酮肟89 3 CHLOROHYDRATE 氢氯酸20 3.3CHLOROMETHANE 氯甲烷-4 12.6 CHLORONAPHTHALENE 溴代萘24 5CHLOROOCTANE 氯辛烷24 5.1CHLOROPHETANE 氯戊烷5.4CHLOROTOLUENE 氯甲苯20 4.7CHLOROTOLUENE, LIQUID 氯甲苯,液体4-4.5 CHOLESTERIN 胆固醇2.86CHOLESTRAL 胆固醇27 2.9CHORINE 氯77 1.7CHROME, OR 铬合金,7.7-8.0CHROME, PURE 铬合金,12CHROMITE 铬铁矿4.0-4.2CHROMYL CHORIDE 氯化铬酰20 2.6 CINNAMALDEHYDE 桂皮醛24 16.9CIS-3-HEXENE 顺式-3-己烯24 2.1CITRACONIC ANHYDRIDE 柠康酐20 40.3CITRACONIC NITRILE 柠康腈27CLAY 粘土1.8 - 2.8CLINKER (CEMENT ) 煤渣(水泥)2.7CO2 CO2 0 1.6COAL TAR 煤焦油2.0-3.0COAL, POWDER, FINE 煤,粉末,精细2/4COCAINE 可卡因20 3.1Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表COFFEE REFUSE 咖啡渣2.4-2.6COKE 焦炭1.1 - 2.2COMPOUND 复方3.6COPPER CATAL YST 催化剂铜6.0 - 6.2COPPER OLEATE 油酸铜20 2.8COPPER OXIDE 氧化铜18.1CORDERITE 堇青石2.5 - 5.4CORN 玉米5/10CORN (DRY GRANULARS ) 玉米(干颗粒)1.8CORN, REFUSE 玉米,拒绝2.3-2.6CORNING GLASS 科尔宁玻璃6.5COTTON 棉花1.3-1.4COTTON SEED OIL 棉子油3.1CREOSOL 木焦油醇17 10.6CRESOL 甲酚24 5CRESOL, LIQUID 甲酚,液体9/11CROTONIC NITRICE 巴豆腈20 28CRYSTALE 晶体3.5-4.7CUMALDEHYDE 枯醛15 11CUMENE 异丙苯20 2.4CUMICALDEHYDE 枯醛14 10.7CUPRIC OLEATE 油酸铜2.8CUPRIC OXIDE 氧化铜16 18.1CUPRIC SULFATE 硫酸铜10.3CUPRIC SULFATE (5H2O) 硫酸铜(5H2O)7.8CUPRIC SULFATE (ANHYD ) 硫酸铜(酐)10.3CY ANOACETIC ACID 氰乙酸4 33CY ANOETHYL ACETATE 醋酸腈乙酯20 19.3CY ANOGEN 氰23 2.6CYCLOHEDANE 环己烷-7 2CYCLOHENANONE 环己酮20 18.2CYCLOHEPTASILOXANE 环庚硅氧烷20 2.7CYCLOHEXANE 环己烷20 2CYCLOHEXANE, LIQUID 环乙烷,液体18.5 CYCLOHEXANECARBOXYLIC ACID 环己烷羧酸31 2.6 CYCLOHEXANEMETHANOL 环己烯甲醇60 9.7 CYCLOHEXANOL 环己醇25 15CYCLOHEXANONE 环己酮20 18.2CYCLOHEXANONE OXIME 环己酮肟89 3CYCLOHEXENE 环己烯20 18.3CYCLOHEXYLAMINE-5 环己胺-5 5.3CYCLOHEXYLPHENOL 环己烯基酚54 4 CYCLOHEXYLTRIFLUOROMETHANE-1 环己烯基三氟甲烷-1 20 11 CYCLOPENTANE 环戊烷20 2CYMENE 62 伞花烃62 2.3D.M.T. (DACRON POWDER) 对苯二甲酸丁二醇酯(涤纶粉末)1.33 D-COCAINE D-古柯碱3.1DECAHYDRONAPHTOLENE 十氢化萘20 2.2Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表DECAMETHYLCYCLOPENTASILOXANE 十甲基环戊硅氧烷20 2.5 DECAMETHYLTETRASILOXANE 十甲基四硅氧烷20 2.4 DECANAL 癸醛8.1DECANE 癸烷20 2DECANOL 癸醇20 8.1DECYLENE 癸烯17 2.7DECYNE 癸炔20 2.2DEUTERIUM 氘20 1.3DEUTERIUM OXIDE 氧化氘25 78.3DEXTRIN 糊精2.2-2.4DIACETOXYBUTANE 二乙酰氧基丁烷24 6.64DIALL YL SULFIDE 二丙烯基硫化物20 4.9DIAMOND 金刚石5.5 - 10.0DIAPHENYLMETHANE 二苯基甲烷2.7DIAPLMITIN 3.5DIBENZOFURAN 二苯駢夫喃100 3DIBENZYL SEBACATE 癸二酸二苄基酯20 4.6DIBENZYLAMINE 二苄胺20 3.6DIBROHEPTANE 二溴庚烷-4 5.08DIBROMOBENZENE 二溴苯20 8.8DIBROMOBUTANE 二溴丁烷20 5.7DIBROMOETHYLENE (CIS-1, 2 ) 二溴乙烯(顺式-1,2)0 7.7 DIBROMOHEPTANE 二溴庚烷24 5.1DIBROMOHEXANE 二溴己烷24 5DIBROMOMETHANE 二溴甲烷10 7.8DIBROMOPROPANE 二溴丙烷20 4.3DIBROMOPROPYL ALCOHOL 二溴丙基21 9.1DIBUTYL PHTHALATE 邻苯二甲酸二丁酯30 6.4DIBUTYL SEBACATE 癸二酸二丁酯30 4.5DIBUTYL TARTRATE 109 酒石酸二丁酯109 9.4 DICHLORACETIC ACID 二氯乙酸-7 10.7DICHLORACETIC ACID 二氯乙酸22 8.2DICHLORACETONE 二氯丙酮20 14DICHLOROBENZENE 二氯苯53 2.8DICHLOROETHANE (1,2) 二氯乙烷(1,2)25 10.3 DICHLOROETHYLENE 二氯乙烯17 4.6DICHLOROMETHANE 二氯甲烷20 9.1DICHLOROSTYRENE 二氯苯乙烯24 2.6DICHLOROTOLUENE 二氯甲苯20 6.9DICTYL PHTHALATE 邻苯二甲酸二CTYL酯5.1 DICYCLOHEXYL ADIPA TE 己二酸二环己酯35 4.8 DIEBENZYLAMINE 二苄胺20 3.6 DIETHYL 1-MALATE 1-苹果酸二乙酯20 9.5DIETHYL BENZALMALONA TE 亚苄基丙二酸二乙酯0 8 DIETHYL DISULFIDE 二乙基二硫化物19 15.9DIETHYL DL-MALATE DL-苹果酸二乙酯18 10.2DIETHYL GLUTARATE 戊二酸二乙酯30 6.7DIETHYL I-MALATE I-苹果酸二己酯9.5Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表DIETHYL KETONE 二乙酮14 17.3DIETHYL L-MALATE L-苹果酸二乙酯20 9.5DIETHYL MALONATE 丙二酸二乙酯21 7.9DIETHYL OXALATE 草酸二乙酯21 8.2DIETHYL OXALOACETA TE 草酸二乙酯19 6.1DIETHYL RACEMATE 外消旋酒石酸二乙酯20 4.5DIETHYL SEBACATE 癸二酸二乙酯30 5DIETHYL SUCCINATE 癸二酸二乙酯30 6.6DIETHYL SUCCINOSUCCINATE 琥珀酰琥珀酸二乙酯19 2.5 DIETHYL SULFIDE 二乙基硫醚20 7.2DIETHYL SULFITE 亚硫酸二乙酯20 15.9DIETHYL TARTRATE 石酸乙酯20 4.5DIETHYL ZINC 二乙基锌20 2.6DIETHYLAMINE 二乙胺20 3.7DIETHYL-DIMALATE 苹果酸氢二乙酯10.2 DIHYDROCAROONE 二氢CAROONE 19 8.7 DIHYDROCARVONE 二氢香芹酮19 8.5 DIIMYLAMINE 18 2.5DIIOAMYLENE 17 2.4DIIODOETHYLENE 1 二碘乙烯-1 27 4 DIIODOMETHANE 二碘甲烷25 5.3DIISOAMYL 二异戊基17 2DIISOAMYLENE 二异戊烯2.4DIISOBUTYLAMINE 二异丁胺22 2.7 DIMETHOXYBENZENE 二甲氧苯23 4.5DIMETHYL ETHYL 二甲基苯酯20 11.7DIMETHYL ETHYL CARBINOL 二甲基乙基甲醇20 11.7 DIMETHYL MALONA TE 丙二酸二甲酯20 10.4DIMETHYL OXALATE 乙二酸二甲酯20 3DIMETHYL PENTANE 二甲基戊烷-7 1.912DIMETHYL PHTHALATE 邻苯二甲酸二甲酯24 8.5DIMETHYL SULFATE 硫酸二甲酯20 55DIMETHYL SULFIDE 二甲硫醚20 6.3DIMETHYL-1-HYDROXYBENZENE 二甲基-1-羟基苯17 4.8DIMETHYL-2-HEXANE 二甲基-2-己烷20 2.4DIMETHYLAMINE 二甲胺0 6.3DIMETHYLANILINE 二甲(基)苯胺20 4.4 DIMETHYLBROMOETHYLENE 二甲基溴乙烯20 6.7 DIMETHYLHEPTANE 二甲基庚烷20 1.9DIMETHYLPENTANE 二甲基戊烷20 1.9DIMETHYLQUINOXALINE 二甲基奎喔啉24 2.3 DIMETHYLTOUIDINE 二甲基TOUIDINE 20 3.3DINITROGEN OXIDE 氧化二氮0 1.6DINITROGEN TETROXIDE 四氧化二氮14 2.5DIOCTYL PHTHALATE 磷苯二甲酸二异辛酯24 5.1DIOXANE 1,4 二氧二乙稀1,4 25 2.2DIPALMITIN 二棕榈酸甘油酯72 3.5DIPENTENE 二戊烯20 2.3Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表DIPENYLAMINE 二戊胺52 3.3DIPHEMYLETHANE 110 2.4DIPHEMYLETHANE 17 12.6DIPHENYL 1 二苯基1 19 2.5DIPHENYL ETHER 二苯醚28 3.9DIPHENYLAMINE 二苯胺51 3.3DIPHENYLETHANE 二苯基乙烷43 2.38DIPHENYTMETHANE 二苯基甲烷17 2.6DIPROPYL KETONE 二丙酮17 12.6DIPROPYLAMINE 二丙胺21 2.9DISTEARIN 二硬脂精78 3.3DOCOSANE 二十二烷50 2 DODECAMETHYLCYCLOHEXISLOXANE 十二甲基环己SLOXANE 20 2.6 DODECAMETHYLPENTASILOXANE 十二甲基环戊SLOXANE 20 2.5 DODECANE 十二烷20 2DODECANOL 十二醇24 6.5DODECYNE 十二炔24 2.2DOLOMITE 白云石6.8-8.0DOWTHERM 道氏热载体21 3.4EBONITE 硬橡胶2.5-2.9EMERY SAND 金刚砂16.5EPICHLORCHYDRIN 表氯醇20 22.9EPOXY RESIN (CAST ) 环氧树脂(铸造)3.6ETHANEDIAMINE 二氨基乙烷20 14.2ETHANETHIOL 乙硫醇14 6.9ETHANETHIOLIC ACID 硫代乙酸20 13ETHANOL 酒精25 24.3ETHELENE DIAMINE 乙撑二胺-8 16ETHELENE OXIDE –1 环氧乙烷-1 13.9ETHOXY-3-METHYLBUTANE 乙氧基-3-甲基丁烷20 4 ETHOXYBENZENE 氧乙基苯20 4.2ETHOXYETHYL ACETATE 乙氧基乙酯30 7.6 ETHOXYNAPTHALONE 乙氧基萘19 3.3ETHOXYPENTANE 乙氧基戊烷23 3.6ETHOXYTOLUENE 乙氧基甲苯20 3.9ETHYL 1-BROBUTYRATE 1-溴丁酸乙酯20 8ETHYL 2-IODOPROPIONATE 2-碘丙酸乙酯20 8.8ETHYL ACETATE 醋酸乙酯25 6ETHYL ACETOACETA TE 乙酰乙酸乙酯22 15.9ETHYL ACETONEOXALATE 丙酮草酸乙酯19 16.1ETHYL ACETOPHENONEOXALATE 乙酰苯酮草酸乙酯19 3.3 ETHYL ALCOHOL 乙醇25 24.3ETHYL AMYL ETHER 乙戊醚20 4ETHYL BENZENE 苯乙烷20 2.5ETHYL BENZOATE 苯甲酸乙酯20 6ETHYL BENZOYLACETA TE 苯甲乙酸乙酯20 12.8ETHYL BENZOYLACETOACETA TE 苯甲酰基乙酰乙酸乙酯21 8.6 ETHYL BENZYL ETHER 苯甲基乙酯20 3.8Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表ETHYL BROMIDE 溴乙烷18 4.9ETHYL BROMOISOBUTYRA TE 溴异丁酸乙酯20 7.9ETHYL BROMOPROPIONATE 溴丙酸乙酯20 9.4ETHYL BUTYRATE 丁酸乙酯19 5.1ETHYL CARBONA TE 乙基碳酸酯20 3.1ETHYL CARBONA TE 乙基碳酸酯49 14.2ETHYL CELLULOSE 乙基纤维素2.8 - 3.9ETHYL CHLORACETATE 氯乙酸乙酯20 11.6ETHYL CHLOROFORMA TE 氯甲酸乙酯20 11.3ETHYL CHLOROPROPIONA TE 氯丙酸乙酯20 10.1ETHYL CINNAMA TE 肉桂酸乙酯19 5.3ETHYL CYANOACETA TE 氰乙酸乙酯20 27ETHYL CYCLOBUTANE 乙基环丁烷20 2ETHYL DODECANOA TE 十二酸乙酯20 3.4ETHYL ETHER 乙醚-100 8.1ETHYL ETHER 乙醚-40 5.7ETHYL ETHER 乙醚20 4.3ETHYL ETHOXYBENZOA TE 乙氧基苯甲酸乙酯21 7.1ETHYL FORMA TE 甲酸乙酯25 7.1ETHYL FORMYLPHENYLACETA TE 甲酰苯乙酸乙酯20 3ETHYL FUMARATE 延胡索酸乙酯23 6.5ETHYL HYDROXYMETHYLENEPHENYLACET 羟基甲撑苯乙酸乙酯5 ETHYL HYDROXYMETHYLENOMALONA TE 羟基甲撑丙二酸乙酯6.6 ETHYL HYDROXY-TETRACARBOXYLATE 羟基四羧酸乙酯5.9 ETHYL HYDROXY-TETROCARBOXYLATE 羟基四羧酸乙酯2.7 ETHYL IODIDE 碘乙烷20 7.4ETHYL ISOTHIOCY ANATE 异硫氰酸乙酯20 19.7ETHYL LEVULINETE 乙酰丙酸乙酯21 12.1ETHYL MALEATE 马来酸乙酯23 8.5ETHYL MERCAPTAN 乙硫醇20 8ETHYL NITRATE 硝酸乙酯20 19.7ETHYL OLEATE 油酸乙酯27 3.2ETHYL PALMITATE 棕榈酸乙酯20 3.2ETHYL PHENYLACETATE 苯乙酸乙酯21 5.4ETHYL PROPIONATE 丙酸乙酯20 5.7ETHYL SALICYLATE 水杨酸乙酯21 8.6ETHYL SILICATE 磷酸乙酯20 4.1ETHYL STEARATE 硬脂酸乙酯40 3ETHYL THIOCYANA TE 硫氰酸乙酯20 29.6ETHYL TRICHLORACETA TE 氯酸盐钠20 7.8ETHYL UNDECANOA TE 十一碳酸乙酯20 3.6ETHYL V ALERATE 戊酸乙酯20 4.7ETHYLAMINE 乙胺21 6.3ETHYLANILINE 乙基苯胺20 5.9ETHYLBENZENE 乙苯24 3ETHYLENE CHLORIDE 氯乙烷20 10.5ETHYLENE CHLOROHYDRIN 二氯乙烷25 26ETHYLENE CYANIDE 氰乙烷58 58.3ETHYLENE DIAMINE 乙二胺18 16Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表ETHYLENE GYLCOL 乙二醇20 37ETHYLENE IODIDE 碘乙烷3.4ETHYLENE OXIDE 环氧乙烷25 14.0ETHYLENE TETRAFLOURIDE 四氟乙烯 1.9-2.0 ETHYLENECHLOROHYDRIN 2-氯乙醇24 25 ETHYLENEDIAMINE 乙二胺18 16ETHYLIC RESIN 乙基树脂2.2-2.3ETHYLPENTANE 乙基戊烷20 1.9ETHYLTOLUENE 乙基甲苯24 2.2ETIBINE 因二烯-50 2.5EUGENOL 丁香酚18 6.1FAB (FROM BOX, 8% MOISTURE ) FAB (来自盒中,8%水分)1.3FENCHONE 茴香酮20 12FERMANIUM TETRACHLORIDE 24 2.4FERRIC OLEATE 油酸铁20 2.6FERROCHROMIUM 铬铁1.5-1.8 FERROMANGANESE 锰铁5.0-5.2FERROUS OXIDE 氧化亚铁16 14.2FERROUS SULFATE 硫酸亚铁14 14.2FLOUR 面粉2.5-3.0FLOURINE 氟-202 1.5FLOURSPAR 6.8FLUOROTOLUENE 氟甲苯30 4.2FL Y ASH 飞灰1.9 - 2.6FORMALIN 甲醛23FORMAMIDE 甲酰胺20 84FORMIC ACID 甲酸16 58FORSTERITE 镁橄榄石6.2FREON 11 氟里昂-11 21 3.1FREON 113 氟里昂-113 21 2.6FREON 12 氟里昂-12 21 2.4FULLER'S EARTH 漂土1.8 - 2.2FURAN 呋喃25 3FURFURAL 喃甲醛20 42FURFURALDEHYDE 糠醛20 41.9GASOLINE 汽油21 2GERBER OATMEAL (IN BOX ) GERBER麦片(来自盒中)1.5 GERMANIUM TETRACHLORIDE 四氯化锗25 2.4GLASS 玻璃3.7-10GLASS (SILICA ) 玻璃(硅石)3.8GLASS, BEAD 玻璃,水珠3.1GLASS, GRANULE 玻璃,颗粒6/7GLASS, RAW MA TERIAL 玻璃,原料2.0-2.5GLUCOHEPTITOL 葡庚糖七醇120 27GL YCERIN, LIQUID 甘油,液体47-68GL YCEROL 甘油25 42.5GL YCEROL 甘油0 47.2Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表GL YCEROL PHTHALATE (CAST ALKYD ) 邻苯二甲酸甘油脂(浇铸醇酸树脂)3.7 -4.0 GL YCERYL TRIOCETATE 21 6GL YCOL 乙二醇25 37GL YCOL 乙二醇50 35.6GL YCOLIC NITRILE 乙二腈20 27GRAIN 谷物3/8GRAPHITE 石墨12/15GUAIACOL 0 愈创木酚0 11GYPSUM 石膏2.5-6.0HAGEMANNIE ESTER HAGEMANNIE酯20 10.6HALOWAX 六氯4.5HEA VY OIL 重油3HEA VY OIL, C 重油,C 2.6HELIUM, LIQUID 液氦1.05HELIUM-3 氦─314 1.055HEPTADECANONE 十七烷酮60 5.3HEPTANE 庚烷20 1.9HEPTANE, LIQUID 庚烷,液体1.9-2.0HEPTANOIC ACID 庚酸2.5HEPTANOIC ACIELD 庚酸22 2.59HEPTANONE 庚酮20 11.9HEPTAONIC ACID 71 2.6HEPTYL ALCOHOL 庚醇21 6.7HEXAMETHYLDISILOXANE 六甲基氧二硅烷20 2.2HEXANE 己烷-90 2HEXANOL 己醇25 13.3HEXANONE 己酮15 14.6 HEXDECAMETHYLCYCLOHEPTASILOXANE 十六甲基环庚硅氧烷20 2.7 HEXYL IODIDE 己基碘20 6.6HEXYLENE 乙烯17 2HEXYLIODIDE 己基碘20 6.6HYDRAZINE 联氨20 52HYDROCHLORIC ACID 盐酸20 4.6HYDROCYANIC ACID 氢氰酸21 2.3HYDROCYANIC ACID 氢氰酸0 158HYDROFLUORIC ACID 氢氟酸0 83.6HYDROGEN 氢227 1.23HYDROGEN 氢100 1.000284HYDROGEN BROMIDE 溴化氢-4 3.8HYDROGEN BROMIDE 溴化氢-84 7HYDROGEN CHLORIDE 氢氟酸28 4.6HYDROGEN CHLORIDE 氢氟酸-122 12HYDROGEN CYANIDE 氰化氢21 95.4HYDROGEN FLUORIDE 氢氟酸0 84.2HYDROGEN FLUORIDE 氢氟酸-73 17HYDROGEN IODIDE 碘化氢22 2.9HYDROGEN IODIDE 碘化氢22 2.9HYDROGEN PEROXIDE 过氧化氢0 84.2Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表HYDROGEN PEROXIDE 100% 过氧化氢100% 70.7HYDROGEN PEROXIDE 35% 过氧化氢35% 121HYDROGEN SULFIDE 硫化氢-64 9.3HYDROGEN SULFIDE 硫化氢9 5.8HYDROXY-4-METHY-2-PENTANONE 羟基-4-甲基-2-戊酮24 18.2 HYDROXYMETHYLENE CAMPHOR 羟基甲撑樟脑30 5.2 HYDROXYMETHYLENEBENZYL CY ANIDE 羟基甲撑苄基氰化物20 6 HYDROXYMETHYLENEHYDROXYMETHYLENEACETOACETA TE羟基甲撑乙酰乙酸羟基甲撑酯7.8HYDROZINE 肼20 52.9IDOHEPTANE 碘庚烷22 4.9IDOHEXANE 碘己烷20 5.4IDO-IODOHEXADECANE IDO-碘十六烷20 3.5IDOMETHANE 碘甲烷20 7IDOPOCTANE 碘壬烷24 4.6IDOTOLUENE 碘甲苯20 6.1ILMENITE 钛铁矿6.0 - 7.0INADOL 60 7.8INDONOL 16 7.8IODINE 碘42 118IODINE 碘11IODINE 碘121 118IODINE (Granular) 碘(粒状)4IODIOCTANE 碘壬烷4.6IODLOCTANE -4 4.62IODOBENZENE 碘苯20 4.6IODOHEPTANE 碘庚烷-6 4.92IODOHEXANE 碘己烷-7 5.37IODOMETHANE 碘甲烷-7 7IODOTOLUENE 碘甲苯-7 6.1IRON OXIDE 氧化铁14.2ISO BUTYL ALCOHOL 乙二醇丁醚18.7-31.7ISO BUTYL IODIDE 异丁基碘5.8ISO BUTYL NITRA TE 硝酸异丁酯11.9ISO BUTYLAMINE 丁胺4.5ISO BUTYRIC ACID 酪酸2.7ISO BUTYRONITRILE 异丁腈20.8ISO V ALERIC ACID 异戊酸20 2.6ISOAMYL ACETATE 乙酸异戊酯20 5.6ISOAMYL ALCOHOL 异戊醇23 15.3ISOAMYL BROMIDE 异戊基溴24 6.1ISOAMYL BUTYRATE 丁酸异戊酯20 3.9ISOAMYL CHLORACETA TE 氯乙酸异戊酯20 7.8ISOAMYL CHLORIDE 异戊基氯18 6.4ISOAMYL CHLOROACETATE 氯乙酸异戊酯7.8ISOAMYL CHLOROFORMATE 氯甲酸异戊酯20 7.8 ISOAMYL LODIDE 异戊基碘18 5.6ISOAMYL PROPIONATE 丙酸异戊酯20 4.2ISOAMYL SALICYLATE 水杨酸异戊酯20 5.4Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表ISOAMYL VALERA TE 异戊酸异戊酯-7 3.6ISOAMYL VALERA TE 戊酸异戊酯19 3.6 ISOAMYLPROPIONA TE 丙酸异戊酯4.2ISOBUTHYL RESIN 异丁橡胶1.4-2.1ISOBUTYL ACETATE 乙酸异丁酯20 5.6ISOBUTYL ALCOHOL 异丁醇20 18.7ISO-BUTYL ALCOHOL 乙二醇丁醚-80 31.7ISO-BUTYL ALCOHOL 乙二醇丁醚0 20 .5ISO-BUTYL ALCOHOL 乙二醇丁醚20 18.7ISOBUTYL BENZOATE 苯甲酸异丁酯20 5.9ISOBUTYL BROMIDE 异丁基溴-7 4ISOBUTYL BROMIDE 异丁基溴20 6.6ISOBUTYL BUTYRATE 丁酸异丁酯20 4ISOBUTYL CHLORIDE 异丁基氯20 7.1ISOBUTYL CHLOROFORMATE 氯甲酸异丁酯20 9.2 ISOBUTYL CYANIDE 异丁基氰化物23 13.3ISOBUTYL FORMA TE 甲酸异丁酯19 6.5ISOBUTYL IODIDE 异丁基碘20 5.8ISO-BUTYL IODIDE 异丁基碘20 5.8ISOBUTYL NITRA TE 硝酸异丁酯19 11.9ISO-BUTYL NITRATE 硝酸异丁酯19 11.9ISOBUTYL RININOLEATE RININ油酸异丁酯21 4.7 ISOBUTYL VALERA TE 戊酸异丁酯19 3.8ISO-BUTYLACETA TE 醋酸异丁酯20 5.6 ISOBUTYLAMINE 异丁胺21 4.5ISO-BUTYLAMINE 异丁胺21 4.5ISOBUTYLBENZENE 异丁基苯17 2.3ISOBUTYLBENZOA TE 苯甲酸异丁酯20 5.9 ISOBUTYLENE BROMIDE 环溴异丁烷20 4ISOBUTYRIC ACID 异丁酸20 2.6ISOBUTYRIC ACID 异丁酸50 2.7ISO-BUTYRIC ACID 异丁酸20 2.7ISOBUTYRIC ANHYDRIDE 异丁酸酐20 13.9 ISOBUTYRONITRILE 异丁25 20.8ISO-BUTYRONITRILE 羟基异丁腈23.9- 20.8ISO-BUTYRONITRILE 羟基异丁腈24 20.8 ISOCAPRONITRILE 异戊基氰20 15.7ISO-IODOHEXADECANE 异碘十六烷3.5ISOOCTANE 辛烷2.1-2.3ISOPHTHALIC ACID 异苯二甲酸1.4ISOPRENE 异戊二烯25 2.1ISOPROPYL ALCOHOL 异丙醇18.3ISO-PROPYL ALCOHOL 异丙醇20 18.3ISOPROPYL BENZENE 异丙基苯20 2.4ISOPROPYL NITRA TE 硝酸异丙酯-11ISO-PROPYL NITRA TE 硝酸异丙酯19 11.5 ISOPROPYLAMINE 异丙胺20 5.5ISOPROPYLETHER 异丙醚25 3.9ISOQUINOLINE 异喹啉24 10.7Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表ISOSAFROL 异黄樟脑21 3.4ISO-VALERIC ACID 异戊酸20 2.7JET FUEL (JP4) 煤油(JP4)21 1.7JET FUEL (MILITARY JP4 ) 煤油(军用JP4)1.7KENT WAX KENT蜡6.5-7.5KEROSENE 煤油21 1.8KYNAR 2LACTIC ACID 乳酸16 22LACTRONITRILE 20 38.4LAD OXIDE 氧化铅25.9LEAD ACETATE 醋酸铅2.5LEAD CARBONATE 碳酸铅16 18.1LEAD CHLORIDE 氯化铅4.2LEAD NITRATE 硝酸铅37.7LEAD NOMOXIDE 一氧化铅16 25.9LEAD OLEATE 油酸铅18 3.2LEAD OXIDE 氧化铅25.9LEAD SULFATE 硫酸铅14.3LEAD SULFITE 亚硫酸铅17.9LEAD TETRACHLORIDE 四氯化铅20 2.8LIME 石灰2.2 - 2.5LIMONENE 柠檬油精20 2.3LINDE 5A MOLECULAR SIEVE, DRY LINDE 5A 分子筛,干燥1.8 LINOLEIC ACID 亚油酸0 2.6 - 2.9LINSEED OIL 亚麻籽油3.2-3.5LIQUIFIED AIR 液化空气1.5LIQUIFIED HYDROGEN 液化氢1.2LITYIUM CHLORIDE 氯化锂11.1LONONE 18 10LPG 液化石油气1.6-1.9MAGANESE DIOXIDE 二氧化锰5-5.2MAGNESIUM OXIDE 氧化镁9.7MAGNESIUM SULFATE 磷酸镁-13MALACHITE 孔雀石-14MALEIC ANHYDRIDE 顺丁烯二酐60 51MALOLIC ANHYDRIDE 丙二酸酐11MALONIC NITRILE 丙二腈36 47MANDELIC NITRILE 扁桃腈23 18.1MANDELITRILE 23 17MANNITOL 甘露醇22 3MARGARINE, LIQUID 人造黄油,液体2.8-3.2m-BROMOANILINE 间溴苯胺19 13m-BROMOTOLUENE 间溴甲苯58 5.4m-CHLOROANALINE 间氯苯胺19 13.4m-CHLOROTOLUENE 间氯甲苯20 5.6Material 物质名* 温度(°C) 介电常数DIELECTRIC CONSTANT REFERENCE GUIDE介电常数参考表m-CREOSOL 间甲酚5m-DICHLOROBENZENE 间二氯苯25 5m-DINITRO BENZENE 间二硝基苯20 2.8MELAMINE FORMALDEHYDE (MF ) 密胺-甲醛(MF)(MF ) MOLDING RESIN (MF)成形树脂5.5 - 6.0(MF ) WITH ALPHA CELLULOSE FILLER (MF) 带有阿尔法纤维素填料7.2 -8.2 (MF ) WITH ASBESTOS FILLER (MF)带有石棉填料6.1 - 6.7(MF ) WITH CELLULOSE FILLER (MF)带有纤维素填料4.7 - 7.0(MF ) WITH FLOCK FILLER (MF)带有短纤维填料5.0 - 6.0(MF ) WITH MACERA TED FABRIC FILLE (MF)带有浸软织物填料6.5 - 6.9 MELAMINE RESIN 三聚氰胺树脂4.7-10.9 MENTHOL 薄荷脑6 3.95MENTHOL 薄荷脑42 4MENTHONOL 薄荷脑6 2.1MENTHONOL 薄荷脑43 2.1MERCURIC CHLORIDE 氯化汞3.2MERCUROUS CHLORIDE 氯化亚汞9.4MERCURY 汞148 1.00074MERCURY CHLORIDE 氯化汞7/14MERCURY DIETHYL 二乙基汞20 2.3MESITYL OXIDE 异亚丙基丙酮20 15.4MESITYLENE 三甲基苯20 2.4MESITYLENE 三甲基苯3.4METHAL CYANOACETATE 氨基乙酸肉豆蔻酯21 29.4METHALLMINE 25 9.4METHANE 甲烷-173 1.7METHANE, LIQUID 甲烷,液体1.7METHANOL 甲醇25 32.6。
GC测定盐酸普拉克索中三乙胺残留量

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MSDS
1 Composition
7 Accident Release Measure
Product Name:MLN4924
Chemical Name:
PROCEDURE(S) OF PERSONAL PRECAUTION(S)-Wear respirator, chemical safety goggles, rubber boots, and heavy
rubber gloves.METHODS FOR CLEANING UP-Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and
wash spill site after material pickup is complete.
Sulfamic acid, [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester
CAS No.:905579-51-38 Accident Release Measure
Appearance: White to off-white solid
Formula:C21H25N5O4S 9 Toxicological Information
Solubility:
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
No data available.
p p p p DMSO
2 Handling and Storage
10 Regulary Information
3 Stability and Reactivity
11Disposal Considerations
CLASSIFICATION- Substance not yet fully tested.SAFETY PHASES- 26-36 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.) 36/37/38 (Irritating to eyes,respiratory system and skin.)
STABILITY- Stable under normal handling conditions.HANDLING- Do not breathe dust. Avoid contact with eyes,
skin,and clothing.Avoid prolonged or repeated exposure.STORAGE- Store in a properly sealed container store at -20℃,shelflife is 2 years.
11 Disposal Considerations 4 Hazards Identification
12 Transport Information
5First Aid RID/ADR- Non-hazardous for road transport. IMDG- Non-hazardous for sea transport.IATA - Non-hazardous for air transport.
As specific country, federal, state and local environmental
regulations vary and change frequently we suggest you contact a local, authorized waste disposal contractor for adequate disposal.
Special indication of hazards to humans and the environment.Irritating to eyes, respiratory system and skin.
MATERIALS TO AVOID- Strong oxidizing agents.REACTIVITY- May emit toxic gasses like Carbon monoxide,Carbon dioxide, Nitrogen oxides upon thermal decomposition.
5 First Aid
13 Other Information
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Medchemexpress LLC shall not be held liable for any damage resulting from h dli f t t ith th b d t
INHALATION- If inhaled, remove to fresh air. If not breathing give, artificial respiration. If breathing is difficult, give oxygen.SKIN CONTACT- In case of contact, immediately wash skin with
soap and copious amounts of water.EYE CONTACT- In case of contact, immediately flush eyes with
copious amounts of water for at least 15 minutes.INGESTION- If swallowed, wash out mouth with water provided person is conscious. Call a physician.
6 Fire Fighting Measures
handling or from contact with the above product.
EXTINGUISHING MEDIA Water spray- Carbon dioxide, dry chemical powder, or appropriate foam.
SPECIAL RISKS Specific Hazard(s)- Emits toxic fumes under fire conditions. SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS Wear self-contained breathing apparatus and protective clothing Caution: Not fully tested. For research purposes only
Medchemexpress LLC
to prevent contact with skin and eyes.
18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A
E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。